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Background: Although non-Hodgkin lymphoma (NHL) is the 6th most common malignancy in Sub-Saharan Africa (SSA), little is known about its management and outcome. Herein, we examined treatment patterns and survival among NHL patients. Methods: We obtained a random sample of adult patients diagnosed between 2011 and 2015 from 11 population-based cancer registries in 10 SSA countries. Descriptive statistics for lymphoma-directed therapy (LDT) and degree of concordance with National Comprehensive Cancer Network (NCCN) guidelines were calculated, and survival rates were estimated. Findings: Of 516 patients included in the study, sub-classification was available for 42.1% (121 high-grade and 64 low-grade B-cell lymphoma, 15 T-cell lymphoma and 17 otherwise sub-classified NHL), whilst the remaining 57.9% were unclassified. Any LDT was identified for 195 of all patients (37.8%). NCCN guideline-recommended treatment was initiated in 21 patients. This corresponds to 4.1% of all 516 patients, and to 11.7% of 180 patients with sub-classified B-cell lymphoma and NCCN guidelines available. Deviations from guideline-recommended treatment were initiated in another 49 (9.5% of 516, 27.2% of 180). By registry, the proportion of all patients receiving guideline-concordant LDT ranged from 30.8% in Namibia to 0% in Maputo and Bamako. Concordance with treatment recommendations was not assessable in 75.1% of patients (records not traced (43.2%), traced but no sub-classification identified (27.8%), traced but no guidelines available (4.1%)). By registry, diagnostic work-up was in part importantly limited, thus impeding guideline evaluation significantly. Overall 1-year survival was 61.2% (95%CI 55.3%-67.1%). Poor ECOG performance status, advanced stage, less than 5 cycles and absence of chemo (immuno-) therapy were associated with unfavorable survival, while HIV status, age, and gender did not impact survival. In diffuse large B-cell lymphoma, initiation of guideline-concordant treatment was associated with favorable survival. Interpretation: This study shows that a majority of NHL patients in SSA are untreated or undertreated, resulting in unfavorable survival. Investments in enhanced diagnostic services, provision of chemo(immuno-)therapy and supportive care will likely improve outcomes in the region. Non-Hodgkin lymphoma (NHL) is the sixth most common type of malignant neoplasia in Sub-Saharan Africa; however, resources for cancer care are limited. This article assesses the application of NHL treatment according to NCCN harmonized guidelines in this region. [ABSTRACT FROM AUTHOR]

Purpose: Stage at diagnosis and receipt of therapy are the most important determinants of breast cancer (BC) survival in sub-Saharan Africa (SSA). Recently, the National Comprehensive Cancer Network therapy guidelines for SSA were published. Our study aimed to describe the cancer-directed therapy (CDT) received by patients with BC at the population level in SSA. Methods: Random samples of patients with BC (≥ 40 cases per registry) who were diagnosed from 2009 to 2015 were drawn from 11 population-based cancer registries—Abidjan, Addis Ababa, Bamako, Brazzaville, Bulawayo, Cotonou, Eldoret, Kampala, Maputo, Namibia and Nairobi—which represented 10 countries in SSA. Active methods were used to update therapy and outcomes of patients with newly diagnosed invasive BC. Results: A total of 834 patients were included, with median age at diagnosis of 48 years (range, 20 to 92 years; 16% diagnosed younger than age 35 years). Among patients with known stage (n = 434), 66% were diagnosed at stage III and IV. Eighty-one percent of all cases were morphologically verified. Detailed information on therapy and/or outcome was available for 533 patients (63.9%), and other files not found were assumed without therapy (worst-case scenario). Of the total cohort, 52% of patients had no record of CDT. Of patients without known metastasis (n = 747), 40.6% received surgery (83.1% mastectomy), 33.6% chemotherapy, and 15.5% radiotherapy. Hormone receptor status (HRS) was known for only 16.3%. Of patients with positive or unknown HRS (n = 714), 18.6% received endocrine therapy. Of 299 patients who received chemotherapy, 51.8% received an anthracycline-based regimen and 32.1% received an anthracycline regimen with an additional taxane. For patients in areas with radiotherapy facilities, use ranged from 26% in Addis to 67% in Namibia. Among patients with stage II and III disease (n = 334), 16.5% received surgery only, 8.4% chemotherapy only, 15% received both, 11.1% received both plus endocrine therapy, 5.7% received both plus radiotherapy, and 16.2% received all four modalities. The 5-year overall survival for all patients was 51.1% (95% CI, 44.9% to 56.9%). Conclusion: More than one half of patients with BC in SSA had no record of CDT. Our finding of four of five patients without HRS testing suggests high underutilization of affordable and tolerable endocrine therapy. Improving access to care and HRS testing may facilitate adherence to resource-stratified guidelines. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST: The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/site/ifc. No COIs from the authors. [ABSTRACT FROM AUTHOR]

Background: To assess population-based quality of cancer care in Sub-Saharan Africa and to identify specific gaps and joint opportunities, we assessed concordance of diagnostic and treatment with NCCN harmonized guidelines for leading cancer types in 10 countries., Methods: Adult patients with female breast cancer (BC), cervical cancer (CC), colorectal cancer (CRC), Non-Hodgkin lymphoma (NHL) and prostate cancer (PC) were randomly drawn from 11 population-based cancer registries. Guideline concordance of diagnostics and treatment was assessed using clinical records. In a sub-cohort of 906 patients with potentially curable cancer (stage I-III BC, CC, CRC, PC, aggressive NHL (any stage)) and documentation for >1 month after diagnosis, we estimated factors associated with guideline-concordant treatment or minor deviations (GCT)., Findings: Diagnostic information as per guidelines was complete for 1030 (31.7%)of 3246 patients included. In the sub-cohort with curable cancer, GCT was documented in 374 (41.3%, corresponding to 11.7% of 3246 included in the population-based cohort): aggressive NHL (59.8%/9.1% population-based), BC (54.5%/19.0%), PC (39.0%/6.1%), CRC (33.9%/9.5%), and CC (27.8%/11.6%). GCT was most frequent in Namibia (73.1% of curable cancer subset/32.8% population-based) and lowest in Kampala, Uganda (13.5%/3.1%). GCT was negatively associated with poor ECOG status, locally advanced stage, origin from low HDI countries, and a diagnosis of CRC or CC., Interpretation: Quality of diagnostic workup and treatment showed major deficits, with considerable disparities among countries and cancer types. Improved diagnostic services are necessary to increase the share of curable cancer in SSA. Treatment components within NCCN guidelines synergetic for several cancers should be prioritized., (© The Author(s) 2024. Published by Oxford University Press.)

Background: Surgery is contributing to the climate crisis, not least in the outpatient sector. The present publication aims to identify the challenges this poses, and to provide clear, preferably evidence-based recommendations on environmental protection while simultaneously reducing costs., Method: Narrative review with a non-systematic search and selection in PubMed/MEDLINE and grey area literature as well as expert interviews., Results: Numerous primary articles, evidence syntheses, practical recommendations for action and checklists were identified and two experts were interviewed. Environmental issues were identified in the production and procurement, transport of people and goods, usage of materials, pharmaceuticals including anesthetic gases and energy consumption in the outpatient practice and also in disposal, recycling, and sterilization. High-quality publications do not describe a lack of knowledge on alternatives but on a lack of implementation in clinical practice. Therefore, the identified issues were classified in the 5‑R scheme (reduce, reuse, recycle, rethink, research) to present recommendations for action, which are synergetic in terms of cost reduction, patient and staff satisfaction. Furthermore, changes in regulatory frameworks are discussed., Conclusion: Outpatient surgery comes with relevant consumption of resources and carbon emissions. There are numerous opportunities for action that combine environmental protection with cost reduction as well as patient and staff satisfaction. Incentives, guidelines, and legal framework conditions are needed for comprehensive environmental protection in the private sector., (© The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2023.)