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4. Improved Survival in Liver Transplant Patients Receiving Prolonged-release Tacrolimus-based Immunosuppression in the European Liver Transplant Registry (ELTR): An Extension Study

Author

Adam, René, Karam, Vincent, Cailliez, Valérie, Trunečka, Pavel, Samuel, Didier, Tisone, Giuseppe, Němec, Petr, Soubrane, Olivier, Schneeberger, Stefan, Gridelli, Bruno, Bechstein, Wolf O., Risaliti, Andrea, Line, Pal-Dag, Vivarelli, Marco, Rossi, Massimo, Pirenne, Jacques, Klempnauer, Jurgen L., Rummo, Aleh, Di Benedetto, Fabrizio, Zieniewicz, Krzysztof, Troisi, Roberto, Paul, Andreas, Vali, Toomas, Kollmar, Otto, Boudjema, Karim, Hoti, Emir, Colledan, Michele, Pratschke, Johan, Lang, Hauke, Popescu, Irinel, Ericzon, Bo-Goran, Strupas, Kestutis, De Simone, Paolo, Kochs, Eberhard, Heyd, Bruno, Gugenheim, Jean, Pinna, Antonio D., Bennet, William, Kazimi, Mirjalal, Bachellier, Philippe, Wigmore, Stephen J., Rasmussen, Allan, Clavien, Pierre-Alain, Hidalgo, Ernest, O’Grady, John G., Zamboni, Frausto, Kilic, Murat, and Duvoux, Christophe

Published
2019
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7. A Bayesian methodology to improve prediction of early graft loss after liver transplantation derived from the Liver Match study

Author

Angelico, M., Cillo, U., Fagiuoli, S., Strazzabosco, M., Caraceni, P., Toniutto, P.L., Nanni Costa, A., Salizzoni, Torino M., Romagnoli, R., Bertolotti, G., Patrono, D., De Carlis, L., Slim, A., Mangoni, J.M.E., Rossi, G., Caccamo, L., Antonelli, B., Mazzaferro, V., Regalia, E., Sposito, C., Colledan, M., Corno, V., Tagliabue, F., Marin, S., Vitale, A., Gringeri, E., Donataccio, M., Donataccio, D., Baccarani, U., Lorenzin, D., Bitetto, D., Valente, U., Gelli, M., Cupo, P., Gerunda, G.E., Rompianesi, G., Pinna, A.D., Grazi, G.L., Cucchetti, A., Zanfi, C., Risaliti, A., Faraci, M.G., Tisone, G., Anselmo, A., Lenci, I., Sforza, D., Agnes, S., Di Mugno, M., Avolio, A.W., Ettorre, G.M., Miglioresi, L., Vennarecci, G., Berloco, P., Rossi, M., Ginanni Corradini, S., Molinaro, A., Calise, F., Scuderi, V., Cuomo, O., Migliaccio, C., Lupo, L., Notarnicola, G., Gridelli, B., Volpes, R., Li Petri, S., Zamboni, F., Carbotta, G., Dedola, S., Nardi, A., Marianelli, T., Gavrila, C., Ricci, A., Vespasiano, F., Angelico, Mario, Nardi, Alessandra, Romagnoli, Renato, Marianelli, Tania, Corradini, Stefano Ginanni, Tandoi, Francesco, Gavrila, Caius, Salizzoni, Mauro, Pinna, Antonio D., Cillo, Umberto, Gridelli, Bruno, De Carlis, Luciano G., Colledan, Michele, Gerunda, Giorgio E., Costa, Alessandro Nanni, and Strazzabosco, Mario

Published
2014
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10. Organ donation from patients with a rare disease is often safe: the italian guidelines

Author

Dallapiccola, Bruno, primary, Moriconi, Stefano, additional, Rugge, Massimo, additional, Cardillo, Massimo, additional, Carcassi, Carlo, additional, Colledan, Michele, additional, Strologo, Luca Dello, additional, Vici, Carlo Dionisi, additional, Facchin, Paola, additional, Gridelli, Bruno, additional, La Rocca, Valentino, additional, Lombardini, Letizia, additional, Mazzucato, Monica, additional, Peritore, Daniela, additional, and Amoroso, Antonio, additional

Published
2022
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11. Phenotypical characterization of 6–21-week gestational age human dermis and epidermal cell isolation methods for in vitro studies on epidermal progenitors

Author

Johnen, Christa, Chinnici, Cinzia, Triolo, Fabio, Plettig, Jörn, Bräutigam, Kirsten, Amico, Giandomenico, Young, Matthew, Over, Patrick, Esteban-Vives, Roger, Schmelzer, Eva, Conaldi, Pier-Giulio, Turner, Morris, Thompson, Robert, Zeilinger, Katrin, Rubin, Peter, Vizzini, Giovanni, Gridelli, Bruno, and Gerlach, Jörg C.

Published
2013
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12. A matched pair analysis of multicenter longterm follow‐up after split‐liver transplantation with extended right grafts

Author

Ross, Michael W., Cescon, Matteo, Angelico, Roberta, Andorno, Enzo, Rossi, Giorgio, Pinna, Antonio, De Carlis, Luciano, Baccarani, Umberto, Cillo, Umberto, Colledan, Michele, Mazzaferro, Vincenzo, Tisone, Giuseppe, Rossi, Massimo, Tuzzolino, Fabio, Pagano, Duilio, Gruttadauria, Salvatore, Mazariegos, George, Gridelli, Bruno, and Spada, Marco

Published
2017
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13. Donor safety in living donor liver donation: An Italian multicenter survey

Author

Lauterio, Andrea, Di Sandro, Stefano, Gruttadauria, Salvatore, Spada, Marco, Di Benedetto, Fabrizio, Baccarani, Umberto, Regalia, Enrico, Melada, Ernesto, Giacomoni, Alessandro, Cescon, Matteo, Cintorino, Davide, Ercolani, Giorgio, Rota, Matteo, Rossi, Giorgio, Mazzaferro, Vincenzo, Risaliti, Andrea, Pinna, Antonio Daniele, Gridelli, Bruno, and De Carlis, Luciano

Published
2017
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14. Antiviral therapy and fibrosis progression in patients with mild–moderate hepatitis C recurrence after liver transplantation. A randomized controlled study

Author

Belli, Luca S., Volpes, Riccardo, Graziadei, Ivo, Fagiuoli, Stefano, Starkel, Peter, Burra, Patrizia, Alberti, Alberto B., Gridelli, Bruno, Vogel, Wolfgang, Pasulo, Luisa, De Martin, Eleonora, Guido, Maria, De Carlis, Luciano, Lerut, Jan, Cillo, Umberto, Burroughs, Andrew K., and Pinzello, Giovambattista

Published
2012
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16. Hepatitis C virus Genotypes and reinfection of the graft during long-term follow-up in 35 liver transplant recipients

Author

Caccamo, Lucio, Gridelli, Bruno, Sampietro, Maurizio, Melada, Ernesto, Doglia, Maurizio, Lunghi, Giovanna, Corbetta, Noemi, Rossi, Giorgio, Colledan, Michele, Fassati, Luigi Rainero, Fiorelli, Gemino, Galmarini, Dinangelo, Mühlbacher, Ferdinand, editor, Gnant, M., editor, Klepetko, W., editor, Längle, F., editor, Laufer, G., editor, Sautner, T., editor, Steininger, R., editor, Wamser, P., editor, and Kootstra, G., editor

Published
1996
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18. Liver Match, a prospective observational cohort study on liver transplantation in Italy: Study design and current practice of donor–recipient matching

Author

Angelico, Mario, Cillo, Umberto, Fagiuoli, Stefano, Gasbarrini, Antonio, Gavrila, Caius, Marianelli, Tania, Costa, Alessandro Nanni, Nardi, Alessandra, Strazzabosco, Mario, Burra, Patrizia, Agnes, Salvatore, Baccarani, Umberto, Calise, Fulvio, Colledan, Michele, Cuomo, Oreste, De Carlis, Luciano, Donataccio, Matteo, Ettorre, Giuseppe M., Gerunda, Giorgio E., Gridelli, Bruno, Lupo, Luigi, Mazzaferro, Vincenzo, Pinna, Antonio, Risaliti, Andrea, Salizzoni, Mauro, Tisone, Giuseppe, Valente, Umberto, Rossi, Giorgio, Rossi, Massimo, and Zamboni, Fausto

Published
2011
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21. Recurrence of primary sclerosing cholangitis after liver transplantation: Analysing the European Liver Transplant Registry and beyond

Author

Visseren, Thijmen, Erler, Nicole Stephanie, Polak, Wojciech Grzegorz, Adam, René, Karam, Vincent, Vondran, Florian Wolfgang Rudolf, Ericzon, Bo‐Goran, Thorburn, Douglas, IJzermans, Jan Nicolaas Maria, Paul, Andreas, Heide, Frans, Taimr, Pavel, Nemec, Petr, Pirenne, Jacques, Romagnoli, Renato, Metselaar, Herold Johnny, Darwish Murad, Sarwa, Vondran, Florian, Bergquist, Annika, Lindström, Lina, Snowdon, Victoria, van der Heide, Frans, Trunecka, Pavel, Salizzoni, Mauro, Arendtsen Rostved, Andreas, Arenga, Giuseppe, Berlakovich, Gabriela A, Candinas, Daniel, Markovic, Sasa, Troisi, Roberto, van Hoek, Bart, Kanmaz, Turan, Dayangac, Murat, Berney, Thierry, Sforza, Daniele, Gridelli, Bruno, Clavien, Pierre‐Alain, Hoppe‐Lotichius, Maria, Senninger, Norbert, Lorf, Thomas, Settmacher, Utz, Cuervas‐Mons, Valentín, Bacakoğlu, Aylin, Nadalin, Silvio, Serra, Valentina, Pacholczyk, Marek, Baccarani, Umberto, Dopazo Taboada, Cristina, Berenguer, Marina, San Juan, Fernando, Detry, Olivier, Stippel, Dirk, Evrard, Philippe, Gugenheim, Jean, Kiliç, Murat, Fernández Selles, Carlos, Norena, Luis Antonio Herrera, Melandro, Fabio, Gonzalez‐Pinto, Ignacio, Nicolini, Daniele, Pardo Sánchez, Fernando, Neumann‐Haefelin, Christoph, Gastroenterology & Hepatology, Surgery, Epidemiology, Visseren, T., Erler, N. S., Polak, W. G., Adam, R., Karam, V., Vondran, F. W. R., Ericzon, B. -G., Thorburn, D., Ijzermans, J. N. M., Paul, A., van der Heide, F., Taimr, P., Nemec, P., Pirenne, J., Romagnoli, R., Metselaar, H. J., Darwish Murad, S., Vondran, F., Bergquist, A., Lindstrom, L., Snowdon, V., Trunecka, P., Salizzoni, M., Arendtsen Rostved, A., Arenga, G., Berlakovich, G. A., Candinas, D., Markovic, S., Troisi, R., van Hoek, B., Kanmaz, T., Dayangac, M., Berney, T., Sforza, D., Gridelli, B., Clavien, P. -A., Hoppe-Lotichius, M., Senninger, N., Lorf, T., Settmacher, U., Cuervas-Mons, V., Bacakoglu, A., Nadalin, S., Serra, V., Pacholczyk, M., Baccarani, U., Dopazo Taboada, C., Berenguer, M., San Juan, F., Detry, O., Stippel, D., Evrard, P., Gugenheim, J., Kilic, M., Fernandez Selles, C., Norena, L. A. H., Melandro, F., Gonzalez-Pinto, I., Nicolini, D., Pardo Sanchez, F., and Neumann-Haefelin, C.

Subjects
Registrie, IMPACT, medicine.medical_treatment, Medizin, 030230 surgery, Liver transplantation, DISEASE, 0302 clinical medicine, Risk Factors, Recurrence, Retrospective Studie, EPIDEMIOLOGY, Registries, POPULATION, bayesian statistics, OUTCOMES, disease recurrence, liver transplantation, patient and graft survival, primary sclerosing cholangitis, surgical procedures, operative, Cohort, primary sclerosing cholangiti, 030211 gastroenterology & hepatology, Registry data, Life Sciences & Biomedicine, Human, bayesian statistic, medicine.medical_specialty, Cholangitis, Sclerosing, Detailed data, Primary sclerosing cholangitis, 03 medical and health sciences, Internal medicine, medicine, Humans, Retrospective Studies, Transplantation, Science & Technology, Proportional hazards model, business.industry, Risk Factor, Bayes Theorem, Patient survival, NATURAL-HISTORY, medicine.disease, RISK-FACTORS, Graft survival, Surgery, business
Abstract

Liver transplantation for primary sclerosing cholangitis (PSC) can be complicated by recurrence of PSC (rPSC). This may compromise graft survival but the effect on patient survival is less clear. We investigated the effect of post-transplant rPSC on graft and patient survival in a large European cohort. Registry data from the European Liver Transplant Registry regarding all first transplants for PSC between 1980 and 2015 were supplemented with detailed data on rPSC from 48 out of 138 contributing transplant centres, involving 1,549 patients. Bayesian proportional hazards models were used to investigate the impact of rPSC and other covariates on patient and graft survival. Recurrence of PSC was diagnosed in 259 patients (16.7%) after a median follow-up of 5.0 years (quantile 2.5%-97.5%: 0.4-18.5), with a significant negative impact on both graft (HR 6.7; 95% CI 4.9-9.1) and patient survival (HR 2.3; 95% CI 1.5-3.3). Patients with rPSC underwent significantly more re-transplants than those without rPSC (OR 3.6, 95% CI 2.7-4.8). PSC recurrence has a negative impact on both graft and patient survival, independent of transplant-related covariates. Recurrence of PSC leads to higher number of re-transplantations and a 33% decrease in 10-year graft survival. ispartof: TRANSPLANT INTERNATIONAL vol:34 issue:8 pages:1455-1467 ispartof: location:Switzerland status: published

Published
2021

26. Long-term Follow-up of a Randomized Trial of Tacrolimus or Cyclosporine A Microemulsion in Children Post Liver Transplantation.

Author

UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Lloyd, Carla, Arshad, Adam, Jara, Paloma, Burdelski, Martin, Gridelli, Bruno, Manzanares, J, Colledan, Michele, Jacquemin, Emmanuel, Reding, Raymond, Baumann, Ulrich, Kelly, Deirdre, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Lloyd, Carla, Arshad, Adam, Jara, Paloma, Burdelski, Martin, Gridelli, Bruno, Manzanares, J, Colledan, Michele, Jacquemin, Emmanuel, Reding, Raymond, Baumann, Ulrich, and Kelly, Deirdre

Abstract

The aim of this study was to determine the long-term efficacy and safety of tacrolimus (Tac) and cyclosporine immunosuppression in pediatric liver transplantation (LTx). One hundred fifty-six patients who had taken part in a multicenter, randomized, open, parallel study of Tac and corticosteroids versus cyclosporine A microemulsion (CyA-ME), corticosteroids, and azathioprine. Patients were assessed at regular intervals up to 14 y after LTx. Analysis was conducted descriptively. In a long-term follow-up, there was a similar incidence of acute rejection (Tac versus CyA-ME, 5 versus 8) and graft loss (5 versus 10). There were 11 deaths in the cohort, which were from infectious complications/malignancy in the Tac group (n = 2/5) and from chronic rejection/liver failure in the CyA-ME group (n = 3/6). A similar incidence of Epstein-Barr virus and posttransplant lymphoproliferative disease was observed (8 versus 8, 3 versus 3). However, there was a greater incidence of cosmetic adverse events in the CyA-ME cohort, with higher incidences of hypertrichosis (8 versus 27) and gum hyperplasia (20 versus 6). Growth improved equally in both groups. Overall, 81% of patients randomized to Tac remained on Tac therapy at study end, compared with 31% of patients randomized to CyA-ME. Common reasons for switching from CyA-ME included steroid-resistant/acute rejection (n = 12/8) and cosmetic changes (n = 8). This study is the first prospective, observational follow-up study of pediatric patients randomized to Tac and CyA-ME to evaluate long-term outcomes. Our analysis was limited by the degree of switchover between the cohorts; however, there were fewer deaths from chronic rejection/liver failure and reduced adverse events with Tac. Long-term use of Tac and Tac combination therapy appears to be safe and effective immunosuppression for pediatric LTx recipients.

Published
2021

34. Multidetector-row computed tomography (MDCT) for the diagnosis of hepatocellular carcinoma in cirrhotic candidates for liver transplantation: prevalence of radiological vascular patterns and histological correlation with liver explants

Author

Luca, Angelo, Caruso, Settimo, Milazzo, Mariapina, Mamone, Giuseppe, Marrone, Gianluca, Miraglia, Roberto, Maruzzelli, Luigi, Carollo, Vincenzo, Minervini, Marta Ida, Vizzini, Giovanni, Grutttadauria, Salvatore, and Gridelli, Bruno

Published
2010
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45. Immunobiology of liver xenotransplantation

Author

Ekser, Burcin, Burlak, Christopher, Waldman, Joshua P, Lutz, Andrew J, Paris, Leela L, Veroux, Massimiliano, Robson, Simon C, Rees, Michael A, Ayares, David, Gridelli, Bruno, Tector, Joseph A, and Cooper, David KC

Published
2012
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