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814 results on '"Gretz, N"'

9. Identifizierung Invasions- und Metastasierungs-assoziierter Gene des duktalen Pankreaskarzinoms im orthotopen SCID-Maus Modell

Author

Niedergethmann, M., Alves, F., Heidrich, B., Neff, J., Pilarsky, C., Grützmann, R., Willeke, F., Post, S., Gretz, N., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Kremer, B., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Junginger, T., editor, Senninger, N., editor, Allgayer, H., editor, Broll, R., editor, Bruns, C. J., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Brückner, U. B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Biemer, E., editor, Germann, G., editor, Haas, N., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Rogiers, X., editor, Jauch, K. W., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Celik, I., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Neuhaus, P., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Zerkowski, H. R., editor, Becker, H. D., editor, Saeger, H. -D., editor, Jauch, K. -W., editor, and Bauer, H., editor

Published
2006
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18. IER2-induced senescence drives melanoma invasion through osteopontin

Author

Kyjacova, L., Saup, R., Rönsch, K., Wallbaum, S., Dukowic-Schulze, S., Foss, A., Scherer, S. D., Rothley, M., Neeb, A., Grau, N., Thiele, W., Thaler, S., Cremers, N., Sticht, C., Gretz, N., Garvalov, B. K., Utikal, J., and Sleeman, J. P.

Subjects
Life sciences, biology, ddc:570
Abstract

Expression of the immediate-early response gene IER2 has been associated with the progression of several types of cancer, but its functional role is poorly understood. We found that increased IER2 expression in human melanoma is associated with shorter overall survival, and subsequently investigated the mechanisms through which IER2 exerts this effect. In experimental melanoma models, sustained expression of IER2 induced senescence in a subset of melanoma cells in a p53/MAPK/AKT-dependent manner. The senescent cells produced a characteristic secretome that included high levels of the extracellular phosphoglycoprotein osteopontin. Nuclear localization of the IER2 protein was critical for both the induction of senescence and osteopontin secretion. Osteopontin secreted by IER2-expressing senescent cells strongly stimulated the migration and invasion of non-senescent melanoma cells. Consistently, we observed coordinate expression of IER2, p53/p21, and osteopontin in primary human melanomas and metastases, highlighting the pathophysiological relevance of IER2-mediated senescence in melanoma progression. Together, our study reveals that sustained IER2 expression drives melanoma invasion and progression through stimulating osteopontin secretion via the stochastic induction of senescence.

Published
2021
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20. Functional characterisation of decoy receptor 3 in Crohn's disease

Author

Funke, B., Autschbach, F., Kim, S., Lasitschka, F., Strauch, U., Rogler, G., Gdynia, G., Li, L., Gretz, N., Macher-Goeppinger, S., Sido, B., Schirmacher, P., Meuer, S.C., and Roth, W.

Subjects
Crohn's disease -- Development and progression, Crohn's disease -- Research, Tumor necrosis factor -- Physiological aspects, Tumor necrosis factor -- Research, Health
Published
2009

24. A complementary study approach unravels novel players in the pathoetiology of Hirschsprung disease

Author

Mederer, T., Schmitteckert, S., Volz, J., Martinez, C., Roth, R., Thumberger, T., Eckstein, V., Scheuerer, J., Thoni, C., Lasitschka, F., Carstensen, L, Gunther, P., Holland-Cunz, S. (Stefan), Hofstra, R.M.W. (Robert), Brosens, E. (Erwin), Rosenfeld, J.A. (Jill), Schaaf, C.P., Schriemer, D, Ceccherini, I. (Isabella), Rusmini, M., Tilghman, J., Luzon-Toro, B., Torroglosa, A., Borrego, S. (Salud), Tang, C.S.M., Garcia-Barcelo, M, Tam, P., Paramasivam, N., Bewerunge-Hudler, M., Dalla Torre, C, Gretz, N. (Norbert), Rappold, G. (Gudrun), Romero, P. (Pedro), Niesler, B., Mederer, T., Schmitteckert, S., Volz, J., Martinez, C., Roth, R., Thumberger, T., Eckstein, V., Scheuerer, J., Thoni, C., Lasitschka, F., Carstensen, L, Gunther, P., Holland-Cunz, S. (Stefan), Hofstra, R.M.W. (Robert), Brosens, E. (Erwin), Rosenfeld, J.A. (Jill), Schaaf, C.P., Schriemer, D, Ceccherini, I. (Isabella), Rusmini, M., Tilghman, J., Luzon-Toro, B., Torroglosa, A., Borrego, S. (Salud), Tang, C.S.M., Garcia-Barcelo, M, Tam, P., Paramasivam, N., Bewerunge-Hudler, M., Dalla Torre, C, Gretz, N. (Norbert), Rappold, G. (Gudrun), Romero, P. (Pedro), and Niesler, B.

Abstract

Hirschsprung disease (HSCR, OMIM 142623) involves congenital intestinal obstruction caused by dysfunction of neural crest cells and their progeny during enteric nervous system (ENS) development. HSCR is a multifactorial disorder; pathogenetic variants accounting for disease phenotype are identified only in a minority of cases, and the identification of novel disease-relevant genes remains challenging. In order to identify and to validate a potential disease-causing relevance of novel HSCR candidate genes, we established a complementary study approach, combining whole exome sequencing (WES) with transcriptome analysis of murine embryonic ENS-related tissues, literature and database

Published
2020
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25. A complementary study approach unravels novel players in the pathoetiology of Hirschsprung disease

Author

Mederer, T, Schmitteckert, S, Volz, J, Martinez, C, Roth, R, Thumberger, T, Eckstein, V, Scheuerer, J, Thoni, C, Lasitschka, F, Carstensen, L, Gunther, P, Holland-Cunz, S, Hofstra, Robert, Brosens, Erwin, Rosenfeld, JA, Schaaf, CP, Schriemer, D, Ceccherini, I, Rusmini, M, Tilghman, J, Luzon-Toro, B, Torroglosa, A, Borrego, S, Tang, CSM, Garcia-Barcelo, M, Tam, P, Paramasivam, N, Bewerunge-Hudler, M, Dalla Torre, C, Gretz, N, Rappold, GA, Romero, P, Niesler, B, Mederer, T, Schmitteckert, S, Volz, J, Martinez, C, Roth, R, Thumberger, T, Eckstein, V, Scheuerer, J, Thoni, C, Lasitschka, F, Carstensen, L, Gunther, P, Holland-Cunz, S, Hofstra, Robert, Brosens, Erwin, Rosenfeld, JA, Schaaf, CP, Schriemer, D, Ceccherini, I, Rusmini, M, Tilghman, J, Luzon-Toro, B, Torroglosa, A, Borrego, S, Tang, CSM, Garcia-Barcelo, M, Tam, P, Paramasivam, N, Bewerunge-Hudler, M, Dalla Torre, C, Gretz, N, Rappold, GA, Romero, P, and Niesler, B

Published
2020

36. A new cell culture model for polycystic kidney disease

Author

Hafner, M., Pey, R., Gretz, N., Bach, J., Schieren, G., Schöffl, Harald, editor, Spielmann, Horst, editor, Tritthart, Helmut A., editor, Cußler, Klaus, editor, Goetschel, Antoine F., editor, Gruber, Franz P., editor, and Reinhardt, Christoph A., editor

Published
1997
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47. Protein restriction and progression of chronic renal failure

Author

Gretz, N. and Strauch, M.

Subjects
Chronic kidney failure -- Diet therapy, Diet therapy -- Analysis
Abstract

Past research were examined to determine the effectiveness of protein restriction on chronic renal disease. Some studies claim that the commonly used medical regimen does not delay progression of chronic renal failure. However, analysis of results using standards such as factor of delay revealed the limitations of these researches. Existing data support the fact that protein limitation actually retard the rate of renal disease progression. Low protein diet (LPD) diminish the risk factors of chronic renal disease incidence. As a result, individuals are encouraged to adhere to LPD in the early stages of the disease.

Published
1992

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