Author: "Grena, P." - Searchworks@Jio Institute Digital Library Search Results

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36 results on '"Grena, P."'

1. Ranking nodes in directed networks via continuous-time quantum walks

Author: Boito, Paola and Grena, Roberto
Subjects: Quantum Physics, Mathematics - Numerical Analysis
Abstract: Four new centrality measures for directed networks based on unitary, continuous-time quantum walks (CTQW) in $n$ dimensions -- where $n$ is the number of nodes -- are presented, tested and discussed. The main idea behind these methods consists in re-casting the classical HITS and PageRank algorithms as eigenvector problems for symmetric matrices, and using these symmetric matrices as Hamiltonians for CTQWs, in order to obtain a unitary evolution operator. The choice of the initial state is also crucial. Two options were tested: a vector with uniform occupation and a vector weighted w.r.t.~in- or out-degrees (for authority and hub centrality, respectively). Two methods are based on a HITS-derived Hamiltonian, and two use a PageRank-derived Hamiltonian. Centrality scores for the nodes are defined as the average occupation values. All the methods have been tested on a set of small, simple graphs in order to spot possible evident drawbacks, and then on a larger number of artificially generated larger-sized graphs, in order to draw a comparison with classical HITS and PageRank. Numerical results show that, despite some pathologies found in three of the methods when analyzing small graphs, all the methods are effective in finding the first and top ten nodes in larger graphs. We comment on the results and offer some insight into the good accordance between classical and quantum approaches.
Published: 2022

2. Quantum hub and authority centrality measures for directed networks based on continuous-time quantum walks

Author: Boito, Paola and Grena, Roberto
Subjects: Mathematics - Numerical Analysis, Quantum Physics
Abstract: In this work we introduce, test and discuss three quantum methods for computing hub and authority centrality scores in directed networks. The methods are based on unitary, continuous-time quantum walks; the construction of a suitable Hermitian Hamiltonian is achieved by performing a quantum walk on the associated bipartite graph. Two methods, called CQAu and CQAw, use the same evolution operator, inspired by the classical HITS algorithm, but with different initial states; the computation of hub and authority scores is performed simultaneously. The third method, called CQG and inspired by classical PageRank, requires instead two separate runs with different evolution operators, one for hub and one for authority scores. The methods are tested on several directed graphs with different sizes and properties; a comparison with other well-established ranking algorithms is provided. CQAw emerges as the most reliable of the three methods and yields rankings that are largely compatible with results from HITS, although CQAu and CQG also present interesting features and potential for applications.
Published: 2021
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3. Ranking nodes in directed networks via continuous-time quantum walks

Author: Boito, Paola and Grena, Roberto
Published: 2023
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4. One-step optogenetics with multifunctional flexible polymer fibers

Author: Park, Seongjun, Guo, Yuanyuan, Jia, Xiaoting, Choe, Han Kyoung, Grena, Benjamin, Kang, Jeewoo, Park, Jiyeon, Lu, Chi, Canales, Andres, Chen, Ritchie, Yim, Yeong Shin, Choi, Gloria B, Fink, Yoel, and Anikeeva, Polina
Subjects: Biotechnology, Neurosciences, Animals, Basolateral Nuclear Complex, Brain, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Channelrhodopsins, Electrodes, Implanted, Evoked Potentials, Hippocampus, Male, Mice, Mice, Transgenic, Motor Activity, Neural Pathways, Neurons, Opsins, Optical Fibers, Optogenetics, Photic Stimulation, Polymers, Prefrontal Cortex, Psychology, Cognitive Sciences, Neurology & Neurosurgery
Abstract: Optogenetic interrogation of neural pathways relies on delivery of light-sensitive opsins into tissue and subsequent optical illumination and electrical recording from the regions of interest. Despite the recent development of multifunctional neural probes, integration of these modalities in a single biocompatible platform remains a challenge. We developed a device composed of an optical waveguide, six electrodes and two microfluidic channels produced via fiber drawing. Our probes facilitated injections of viral vectors carrying opsin genes while providing collocated neural recording and optical stimulation. The miniature (
Published: 2017

5. Magnetothermoelectric properties of Bi2Se3

Author: Fauqué, B., Butch, N. P., Syers, P., Paglione, J., Wiedmann, S., Collaudin, A., Grena, B., Zeitler, U., and Behnia, K.
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract: We present a study of entropy transport in Bi2Se3 at low temperatures and high magnetic fields. In the zero-temperature limit, the magnitude of the Seebeck coefficient quantitatively tracks the Fermi temperature of the 3D Fermi surface at \Gamma-point as the carrier concentration changes by two orders of magnitude (10$^{17}$ to 10$^{19}$cm$^{-3}$). In high magnetic fields, the Nernst response displays giant quantum oscillations indicating that this feature is not exclusive to compensated semi-metals. A comprehensive analysis of the Landau Level spectrum firmly establishes a large $g$-factor in this material and a substantial decrease of the Fermi energy with increasing magnetic field across the quantum limit. Thus, the presence of bulk carriers significantly affects the spectrum of the intensively debated surface states in Bi2Se3 and related materials., Comment: 10 pages, 9 figures
Published: 2012
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6. Superconformal Vacua in N=2 Usp(4) Gauge Theories

Author: Auzzi, Roberto and Grena, Roberto
Subjects: High Energy Physics - Theory
Abstract: We study the dynamics of a confining vacuum in N=2 USp(4) gauge theory with n_f=4. The vacuum appears to be a deformed conformal theory with nonabelian gauge symmetry. The low-energy degrees of freedom consist of four nonabelian magnetic monopole doublets of the effective SU(2) colour group, two dyon doublets and one electric doublet. In this description the flavour quantum number is carried only by the monopoles. We argue that confinement is caused by the condensation of these monopoles, and involves strongly interacting nonabelian degrees of freedom., Comment: 18 pages, 5 figures
Published: 2004

7. Almost Conformal Vacua and Confinement

Author: Auzzi, Roberto, Grena, Roberto, and Konishi, Kenichi
Subjects: High Energy Physics - Theory
Abstract: Dynamics of confining vacua which appear as deformed superconformal theory with a non-Abelian gauge symmetry, is studied by taking a concrete example of the sextet vacua of ${\cal N}=2$, SU(3) gauge theory with $n_f=4$, with equal quark masses. We show that the low-energy "matter" degrees of freedom of this theory consist of four magnetic monopole doublets of the low-energy effective SU(2) gauge group, one dyon doublet, and one electric doublet. We find a mechanism of cancellation of the beta function, which naturally but nontrivially generalizes that of Argyres-Douglas. Study of our SCFT theory as a limit of six colliding ${\cal N}=1$ vacua, suggests that the confinement in the present theory occurs in an essentially different manner from those vacua with dynamical Abelianization, and involves strongly interacting non-Abelian magnetic monopoles., Comment: 27 pages, 11 figures, LaTex file
Published: 2002
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8. Confinement, asymptotic freedom and renormalons in type 0 string duals

Author: Grena, Roberto, Lelli, Simone, Maggiore, Michele, and Rissone, Anna
Subjects: High Energy Physics - Theory
Abstract: Type 0B string theory has been proposed as the dual description of non-supersymmetric SU(N) Yang-Mills theory coupled to six scalars, in four dimensions. We study numerically and analytically the equations of motion of type 0B gravity and we find RG trajectories of the dual theory that flow from an asymptotically free UV regime to a confining IR regime. In the UV we find a one-parameter family of solutions that approach asymptotically $AdS_5\times S^5$ with a logarithmic flow of the coupling plus non-perturbative terms that correctly reproduce all UV and IR renormalon singularities. The first UV renormalon gives a contribution $\sim F_1(E)/E^2$ and we are able to predict also the form of the function $F_1(E)$, which, from the YM side, corresponds to summing all multiple-chain bubble graphs. The fact that the positions of the renormalon singularities in the Borel plane come out correctly is a non-trivial test of the conjectured duality., Comment: 29 pages, 10 figures, Latex (uses JHEP.cls); v2: references added
Published: 2000
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9. Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice:: GLORIA-AF Registry

Author: Lip G. Y. H., Kotalczyk A., Teutsch C., Diener H. -C., Dubner S. J., Halperin J. L., Ma C. -S., Rothman K. J., Marler S., Gurusamy V. K., Huisman M. V., Abban D. W., Aziz E., Kalan M. B., Abdul N., Backes L. M., Bradman D., Abud A. M., Badings E., Brautigam D., Adams F., Bagni E., Breton N., Addala S., Baker S. H., Brouwers P. J. A. M., Adragao P., Bala R., Browne K., Ageno W., Baldi A., Cortada J. B., Aggarwal R., Bando S., Bruni A., Agosti S., Banerjee S., Brunschwig C., Agostoni P., Bank A., Buathier H., Aguilar F., Esquivias G. B., Buhl A., Linares J. A., Barr C., Bullinga J., Aguinaga L., Bartlett M., Cabrera J. W., Ahmed J., Basic Kes V., Caccavo A., Aiello A., Baula G., Cai S., Ainsworth P., Behrens S., Caine S., Aiub J. R., Bell A., Calo L., Al-Dallow R., Benedetti R., Calvi V., Alderson L., Mazuecos J. B., Sanchez M. C., Velasco J. A. A., Benhalima B., Candeias R., Alexopoulos D., Bergler-Klein J., Capuano V., Manterola F. A., Berneau J. -B., Capucci A., Aliyar P., Bernstein R. A., Caputo R., Alonso D., Berrospi P., Rizo T. C., da Costa F. A. A., Berti S., Cardona F., Amado J., Berz A., da Costa Darrieux F. C., Amara W., Best E., Vera Y. C. D., Amelot M., Bettencourt P., Carolei A., Amjadi N., Betzu R., Carreno S., Ammirati F., Bhagwat R., Carvalho P., Andrade M., Bhatta L., Cary S., Andrawis N., Biscione F., Casu G., Annoni G., Bisignani G., Cavallini C., Ansalone G., Black T., Cayla G., Ariani M. K., Bloch M. J., Celentano A., Arias J. C., Bloom S., Cha T. -J., Armero S., Blumberg E., Cha K. S., Arora C., Bo M., Chae J. K., Aslam M. S., Bohmer E., Chalamidas K., Asselman M., Bollmann A., Challappa K., Audouin P., Bongiorni M. G., Chand S. P., Augenbraun C., Boriani G., Chandrashekar H., Aydin S., Boswijk D. J., Chartier L., Bott J., Chatterjee K., Ayryanova I., Bottacchi E., Ayala C. A. C., Cheema A., Davis G., Evonich R., Davy J. -M., Evseeva O., Chen L., Dayer M., Ezhov A., Chen S. -A., De Biasio M., Fahmy R., Chen J. H., De Bonis S., Fang Q., Chiang F. -T., De Caterina R., Farsad R., Chiarella F., De Franceschi T., Fauchier L., Chih-Chan L., de Groot J. R., Favale S., Cho Y. K., De Horta J., Fayard M., Choi J. -I., De La Briolle A., Fedele J. L., Choi D. J., de la Pena Topete G., Fedele F., Chouinard G., de Paola A. A. V., Fedorishina O., Chow D. H. -F., de Souza W., Fera S. R., Chrysos D., de Veer A., Ferreira L. G. G., Chumakova G., De Wolf L., Ferreira J., Valenzuela E. J. J. R. C., Decoulx E., Ferri C., Nica N. C., Deepak S., Ferrier A., Cislowski D. J., Defaye P., Ferro H., Clay A., Munoz F. D. -C., Finsen A., Clifford P., Brkljacic D. D., First B., Cohen A., Deumite N. J., Fischer S., Cohen M., Di Legge S., Fonseca C., Cohen S., Diemberger I., Almeida L. F., Colivicchi F., Dietz D., Forman S., Collins R., Dionisio P., Frandsen B., Colonna P., Dong Q., French W., Compton S., dos Santos F. R., Friedman K., Connolly D., Dotcheva E., Friese A., Conti A., Doukky R., Fruntelata A. G., Buenostro G. C., D'Souza A., Fujii S., Coodley G., Dubrey S., Fumagalli S., Cooper M., Ducrocq X., Fundamenski M., Coronel J., Dupljakov D., Furukawa Y., Corso G., Duque M., Gabelmann M., Sales J. C., Dutta D., Gabra N., Cottin Y., Duvilla N., Gadsboll N., Covalesky J., Duygun A., Galinier M., Cracan A., Dziewas R., Gammelgaard A., Crea F., Eaton C. B., Ganeshkumar P., Crean P., Eaves W., Gans C., Crenshaw J., Ebels-Tuinbeek L. A., Quintana A. G., Cullen T., Ehrlich C., Gartenlaub O., Darius H., Eichinger-Hasenauer S., Gaspardone A., Dary P., Eisenberg S. J., Genz C., Dascotte O., Jabali A. E., Georger F., Dauber I., Shahawy M. E., Georges J. -L., Davalos V., Hernandes M. E., Georgeson S., Davies R., Izal A. E., Giedrimas E., Gierba M., Haruna T., Jarmukli N., Ortega I. G., Hayek E., Jeanfreau R. J., Gillespie E., Healey J., Jenkins R. D., Giniger A., Hearne S., Sanchez C. J., Giudici M. C., Heffernan M., Jimenez J., Gkotsis A., Heggelund G., Jobe R., Glotzer T. V., Heijmeriks J. A., Joen-Jakobsen T., Gmehling J., Hemels M., Jones N., Gniot J., Hendriks I., Jorge J. C. M., Goethals P., Henein S., Jouve B., Goldbarg S., Her S. -H., Jung B. C., Goldberg R., Hermany P., Jung K. T., Goldmann B., Del Rio J. E. H., Jung W., Golitsyn S., Higashino Y., Kachkovskiy M., Gomez S., Hill M., Kafkala K., Mesa J. G., Hisadome T., Kalinina L., Gonzalez V. B., Hishida E., Kallmunzer B., Hermosillo J. A. G., Hoffer E., Kamali F., Lopez V. M. G., Hoghton M., Kamo T., Gorka H., Hong K., Kampus P., Gornick C., Hong S., Kashou H., Gorog D., Horbach S., Kastrup A., Gottipaty V., Horiuchi M., Katsivas A., Goube P., Hou Y., Kaufman E., Goudevenos I., Hsing J., Kawai K., Graham B., Huang C. -H., Kawajiri K., Greer G. S., Huckins D., Kazmierski J. F., Gremmler U., Hughes K., Keeling P., Grena P. G., Huizinga A., Saraiva J. F. K., Grond M., Hulsman E. L., Ketova G., Gronda E., Hung K. -C., Khaira A. S., Gronefeld G., Hwang G. -S., Khripun A., Gu X., Ikpoh M., Kim D. -I., Torres I. G. T., Imberti D., Kim Y. H., Guardigli G., Ince H., Kim N. H., Guevara C., Indolfi C., Kim D. K., Guignier A., Inoue S., Kim J. S., Gulizia M., Irles D., Gumbley M., Iseki H., Kim K. S., Gunther A., Israel C. N., Kim J., Ha A., Iteld B., Kinova E., Hahalis G., Iyer V., Klein A., Hakas J., Jackson-Voyzey E., Kmetzo J. J., Hall C., Jaffrani N., Kneller G. L., Han B., Jager F., Knezevic A., Han S., James M., Koh S. M. A., Hargrove J., Jang S. -W., Koide S., Hargroves D., Jaramillo N., Kollias A., Kooistra J. A., Li W., McClure J., Koons J., Li X., McCormack T., Koschutnik M., Lichy C., McGarity W., Kostis W. J., Lieber I., McIntyre H., Kovacic D., Rodriguez R. H. L., McLaurin B., Kowalczyk J., Lin H., Alvaro F., Palomino M., Koziolova N., Melandri F., Kraft P., Liu F., Meno H., Kragten J. A., Liu H., Menzies D., Krantz M., Esperon G. L., Mercader M., Krause L., Navarro N. L., Meyer C., Krenning B. J., Lo E., Meyer B. J., Krikke F., Lokshyn S., Miarka J., Kromhout Z., Lopez A., Mibach F., Krysiak W., Lopez-Sendon J. L., Michalski D., Kumar P., Filho A. M. L., Michel P., Kumler T., Lorraine R. S., Chreih R. M., Kuniss M., Luengas C. A., Luengas A., Mikdadi G., Kuo J. -Y., Luke R., Mikus M., Kuppers A., Luo M., Milicic D., Kurrelmeyer K., Lupovitch S., Militaru C., Kwak C. H., Lyrer P., Minaie S., Laboulle B., Ma C., Minescu B., Labovitz A., Ma G., Mintale I., Ter Lai W., Madariaga I., Mirault T., Lam A., Maeno K., Mirro M. J., Lam Y. Y., Magnin D., Mistry D., Lanas Zanetti F., Maid G., Miu N. V., Landau C., Mainigi S. K., Miyamoto N., Landini G., Makaritsis K., Moccetti T., Lanna Figueiredo E., Malhotra R., Mohammed A., Larsen T., Manning R., Nor A. M., Lavandier K., Manolis A., Mollerus M., LeBlanc J., Hurtado H. A. M., Molon G., Lee M. H., Mantas I., Mondillo S., Lee C. -H., Jattin F. M., Moniz P., Lehman J., Maqueda V., Mont L., Leitao A., Marchionni N., Montagud V., Lellouche N., Ortuno F. M., Montana O., Lelonek M., Santana A. M., Monti C., Lenarczyk R., Martinez J., Moretti L., Lenderink T., Maskova P., Mori K., Gonzalez S. L., Hernandez N. M., Moriarty A., Leong-Sit P., Matsuda K., Morka J., Leschke M., Maurer T., Moschini L., Ley N., Mauro C., Moschos N., Li Z., May E., Mugge A., Mayer N., Mulhearn T. J., Muresan C., Jose E. P., Precoma D. B., Muriago M., Padilla F. G. P., Prelle A., Musial W., Rios V. P., Prodafikas J., Musser C. W., Pajes G., Protasov K., Musumeci F., Pandey A. S., Pye M., Nageh T., Paparella G., Qiu Z., Nakagawa H., Paris F., Quedillac J. -M., Nakamura Y., Park H. W., Raev D., Nakayama T., Park J. S., Grado C. A. R., Nam G. -B., Parthenakis F., Rahimi S., Nanna M., Passamonti E., Raisaro A., Natarajan I., Patel R. J., Rama B., Nayak H. M., Patel J., Ramos R., Naydenov S., Patel M., Ranieri M., Nazlic J., Patrick J., Raposo N., Nechita A. C., Jimenez R. P., Rashba E., Nechvatal L., Paz A., Rauch-Kroehnert U., Negron S. A., Pengo V., Reddy R., Neiman J., Pentz W., Renda G., Neuenschwander F. C., Perez B., Reza S., Neves D., Rios A. M. P., Ria L., Neykova A., Perez-Cabezas A., Richter D., Miguel R. N., Perlman R., Rickli H., Nijmeh G., Persic V., Rieker W., Nizov A., Perticone F., Vera T. R., Campos R. N., Peters T. K., Ritt L. E., Nossan J., Petkar S., Roberts D., Novikova T., Pezo L. F., Briones I. R., Nowalany-Kozielska E., Pflucke C., Escudero A. E. R., Nsah E., Pham D. N., Pascual C. R., Fragoso J. C. N., Phillips R. T., Roman M., Nurgalieva S., Phlaum S., Romeo F., Nuyens D., Pieters D., Ronner E., Nyvad O., Pineau J., Roux J. -F., de Los Rios Ibarra M. O., Pinter A., Rozkova N., O'Donnell P., Pinto F., Rubacek M., O'Donnell M., Pisters R., Rubalcava F., Oh S., Pivac N., Russo A. M., Oh Y. S., Pocanic D., Rutgers M. P., Oh D., Podoleanu C., Rybak K., O'Hara G., Politano A., Said S., Oikonomou K., Poljakovic Z., Sakamoto T., Olivares C., Pollock S., Salacata A., Oliver R., Garcea J. P., Salem A., Ruiz R. O., Poppert H., Bodes R. S., Olympios C., Porcu M., Saltzman M. A., Omaszuk-Kazberuk A., Reino A. P., Salvioni A., Asensi J. O., Prasad N., Vallejo G. S., Fernandez M. S., Sokal A., Tu T. M., Saporito W. F., Yan Y. S. O., Tuininga Y., Sarikonda K., Sotolongo R., Turakhia M., Sasaoka T., de Souza O. F., Turk S., Sati H., Sparby J. A., Turner W., Savelieva I., Spinar J., Tveit A., Scala P. -J., Sprigings D., Tytus R., Schellinger P., Spyropoulos A. C., Valadao C., Scherr C., Stakos D., van Bergen P. F. M. M., Schmitz L., Steinwender C., van de Borne P., Schmitz K. -H., Stergiou G., van den Berg B. J., Schmitz B., Stiell I., van der Zwaan C., Schnabel T., Stoddard M., Van Eck M., Schnupp S., Stoikov A., Vanacker P., Schoeniger P., Streb W., Vasilev D., Schon N., Styliadis I., Vasilikos V., Schwimmbeck P., Su G., Vasilyev M., Seamark C., Su X., Veerareddy S., Searles G., Sudnik W., Mino M. V., Seidl K. -H., Sukles K., Venkataraman A., Seidman B., Sun X., Verdecchia P., Sek J., Swart H., Versaci F., Sekaran L., Szavits-Nossan J., Vester E. G., Serrati C., Taggeselle J., Vial H., Shah N., Takagi Y., Victory J., Shah V., Takhar A. P. S., Villamil A., Shah A., Tamm A., Vincent M., Shah S., Tanaka K., Vlastaris A., Sharma V. K., Tanawuttiwat T., Dahl J., Shaw L., Tang S., Vora K., Sheikh K. H., Tang A., Vranian R. B., Shimizu N., Tarsi G., Wakefield P., Shimomura H., Tassinari T., Wang N., Shin D. -G., Tayal A., Wang M., Shin E. -S., Tayebjee M., Wang X., Shite J., Berg J. M., Wang F., Sibilio G., Tesloianu D., Wang T., Silver F., The S. H. K., Warner A. L., Sime I., Thomas D., Watanabe K., Simmers T. A., Timsit S., Wei J., Singh N., Tobaru T., Weimar C., Siostrzonek P., Tomasik A. R., Weiner S., Smadja D., Torosoff M., Weinrich R., Smith D. W., Touze E., Wen M. -S., Snitman M., Trendafilova E., Wiemer M., Filho D. S., Tsai W. K., Wiggers P., Soda H., Tse H. F., Wilke A., Sofley C., Tsutsui H., Williams D., Williams M. L., Yan P. Y. B., Zhang P., Witzenbichler B., Yang T., Zhang J., Wong B., Yao J., Zhao S. P., Wong K. S. L., Yeh K. -H., Zhao Y., Wozakowska-Kaplon B., Yin W. H., Zhao Z., Wu S., Yotov Y., Zheng Y., Wu R. C., Zahn R., Zhou J., Wunderlich S., Zarich S., Zimmermann S., Wyatt N., Zenin S., Zini A., Wylie J., Zeuthen E. L., Zizzo S., Xu Y., Zhang H., Zong W., Xu X., Zhang D., Zukerman L. S., Yamanoue H., Zhang X., Yamashita T., Cardiology, ACS - Heart failure & arrhythmias, Lip G.Y.H., Kotalczyk A., Teutsch C., Diener H.-C., Dubner S.J., Halperin J.L., Ma C.-S., Rothman K.J., Marler S., Gurusamy V.K., Huisman M.V., Abban D.W., Aziz E., Kalan M.B., Abdul N., Backes L.M., Bradman D., Abud A.M., Badings E., Brautigam D., Adams F., Bagni E., Breton N., Addala S., Baker S.H., Brouwers P.J.A.M., Adragao P., Bala R., Browne K., Ageno W., Baldi A., Cortada J.B., Aggarwal R., Bando S., Bruni A., Agosti S., Banerjee S., Brunschwig C., Agostoni P., Bank A., Buathier H., Aguilar F., Esquivias G.B., Buhl A., Linares J.A., Barr C., Bullinga J., Aguinaga L., Bartlett M., Cabrera J.W., Ahmed J., Basic Kes V., Caccavo A., Aiello A., Baula G., Cai S., Ainsworth P., Behrens S., Caine S., Aiub J.R., Bell A., Calo L., Al-Dallow R., Benedetti R., Calvi V., Alderson L., Mazuecos J.B., Sanchez M.C., Velasco J.A.A., Benhalima B., Candeias R., Alexopoulos D., Bergler-Klein J., Capuano V., Manterola F.A., Berneau J.-B., Capucci A., Aliyar P., Bernstein R.A., Caputo R., Alonso D., Berrospi P., Rizo T.C., da Costa F.A.A., Berti S., Cardona F., Amado J., Berz A., da Costa Darrieux F.C., Amara W., Best E., Vera Y.C.D., Amelot M., Bettencourt P., Carolei A., Amjadi N., Betzu R., Carreno S., Ammirati F., Bhagwat R., Carvalho P., Andrade M., Bhatta L., Cary S., Andrawis N., Biscione F., Casu G., Annoni G., Bisignani G., Cavallini C., Ansalone G., Black T., Cayla G., Ariani M.K., Bloch M.J., Celentano A., Arias J.C., Bloom S., Cha T.-J., Armero S., Blumberg E., Cha K.S., Arora C., Bo M., Chae J.K., Aslam M.S., Bohmer E., Chalamidas K., Asselman M., Bollmann A., Challappa K., Audouin P., Bongiorni M.G., Chand S.P., Augenbraun C., Boriani G., Chandrashekar H., Aydin S., Boswijk D.J., Chartier L., Bott J., Chatterjee K., Ayryanova I., Bottacchi E., Ayala C.A.C., Cheema A., Davis G., Evonich R., Davy J.-M., Evseeva O., Chen L., Dayer M., Ezhov A., Chen S.-A., De Biasio M., Fahmy R., Chen J.H., De Bonis S., Fang Q., Chiang F.-T., De Caterina R., Farsad R., Chiarella F., De Franceschi T., Fauchier L., Chih-Chan L., de Groot J.R., Favale S., Cho Y.K., De Horta J., Fayard M., Choi J.-I., De La Briolle A., Fedele J.L., Choi D.J., de la Pena Topete G., Fedele F., Chouinard G., de Paola A.A.V., Fedorishina O., Chow D.H.-F., de Souza W., Fera S.R., Chrysos D., de Veer A., Ferreira L.G.G., Chumakova G., De Wolf L., Ferreira J., Valenzuela E.J.J.R.C., Decoulx E., Ferri C., Nica N.C., Deepak S., Ferrier A., Cislowski D.J., Defaye P., Ferro H., Clay A., Munoz F.D.-C., Finsen A., Clifford P., Brkljacic D.D., First B., Cohen A., Deumite N.J., Fischer S., Cohen M., Di Legge S., Fonseca C., Cohen S., Diemberger I., Almeida L.F., Colivicchi F., Dietz D., Forman S., Collins R., Dionisio P., Frandsen B., Colonna P., Dong Q., French W., Compton S., dos Santos F.R., Friedman K., Connolly D., Dotcheva E., Friese A., Conti A., Doukky R., Fruntelata A.G., Buenostro G.C., D'Souza A., 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Zhang D., Zukerman L.S., Yamanoue H., Zhang X., and Yamashita T.
Subjects: Apixaban, Atrial fibrillation, Dabigatran, Non-vitamin K antagonists, Rivaroxaban, Pyridones, Medizin, Myocardial Infarction, Administration, Oral, Anticoagulants, Hemorrhage, General Medicine, Non-vitamin K antagonist, Stroke, Clinical Trials, Phase III as Topic, Humans, Prospective Studies, Registries, Cardiology and Cardiovascular Medicine
Abstract: Background and purpose Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). Methods In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest. Results The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014 and December 2016. Of these, 3839 were prescribed dabigatran, 4015 rivaroxaban and 4505 apixaban, with median ages of 71.0, 71.0, and 73.0 years, respectively. In the PS-matched set, the adjusted HRs and 95% confidence intervals (CIs) for dabigatran vs rivaroxaban were, for stroke: 1.27 (0.79–2.03), major bleeding 0.59 (0.40–0.88), myocardial infarction 0.68 (0.40–1.16), and all-cause death 0.86 (0.67–1.10). For the comparison of dabigatran vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 1.16 (0.76–1.78), myocardial infarction 0.84 (0.48–1.46), major bleeding 0.98 (0.63–1.52) and all-cause death 1.01 (0.79–1.29). For the comparison of rivaroxaban vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 0.78 (0.52–1.19), myocardial infarction 0.96 (0.63–1.45), major bleeding 1.54 (1.14–2.08), and all-cause death 0.97 (0.80–1.19). Conclusions Patients treated with dabigatran had a 41% lower risk of major bleeding compared with rivaroxaban, but similar risks of stroke, MI, and death. Relative to apixaban, patients treated with dabigatran had similar risks of stroke, major bleeding, MI, and death. Rivaroxaban relative to apixaban had increased risk for major bleeding, but similar risks for stroke, MI, and death. Registration URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01468701, NCT01671007. Date of registration: September 2013. Graphical abstract
Published: 2022
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10. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial

Author: Bhatt, D, Steg, P, Mehta, S, Leiter, L, Simon, T, Fox, K, Held, C, Andersson, M, Himmelmann, A, Ridderstrale, W, Chen, J, Song, Y, Diaz, R, Goto, S, James, S, Ray, K, Parkhomenko, A, Kosiborod, M, Mcguire, D, Harrington, R, Santos, V, Jain, A, Lendel, I, Russo, M, Haught, W, Bouza, M, Gogia, H, Banerjee, S, Kichura, G, Kantaros, L, Padron, F, Passi, R, Stone, J, Pursley, M, D'Urso, M, Gardner, T, Bennett, J, Nour, K, Saini, S, Zhang, W, Kumbhani, D, Thomas, D, Angiolillo, D, Bertolet, B, Roman-Miranda, A, Black, R, Manshadi, R, Vaca, C, Blanco, A, Napoli, M, Brabham, D, Akyea-Djamson, A, Desai, P, Prasada, S, Khaira, A, Forgosh, L, Lieber, I, Umpierrez, G, Singal, D, Londono, J, Fraser, N, Ruiz, J, Vega, D, Rodriguez, L, Brown, C, Syed, F, Aggarwala, G, Eaves, W, Foster, M, Gupta, D, Avino, D, Asfour, W, Tonnessen, G, Zhao, X, Singh, N, Brockmyre, A, Lepor, N, Shammas, N, Blick, D, Hearne, S, Prodafikas, J, Carell, E, Izzo, M, Karim, A, Zakhary, B, Atieh, M, Leichter, S, Meadows, C, Hotchkiss, D, Abu-Fadel, M, Wiseman, A, Bander, J, Shah, M, Ganim, R, Sopko, K, Khan, M, Lloret, R, Weirick, T, Mehta, R, Thadani, U, Bhargava, A, Moya, J, Staniloae, C, Guerra, Y, Chhabra, A, Kosmicki, D, Shaheen, W, Mohammed, A, Bitters, J, Pattanayak, J, Javier, J, Srivastava, S, Phillips, R, Al-Amin, J, Lillestol, M, Simpson, P, Hazan, L, Amin, A, Shah, G, Korpas, D, Platt, B, Dickert, J, Puente, O, Hiotis, L, Doyle, T, Rajan, R, Meholick, A, Gring, C, Hage-Korban, E, Feldman, R, Colfer, H, Butman, S, Hart, T, Huling, R, Eshaghian, S, Quintana, O, Cheung, D, Handel, F, Rodriguez, M, Suh, D, Gordon, P, Pressman, G, Bauer, M, French, W, Barettella, M, Chatrathi, S, Suresh, D, Goldberg, R, Huth, M, Younis, L, Rahman, A, Mascolo, R, Welch, M, Suneja, R, Smith, S, Shurmur, S, Agaiby, J, Jingo, A, Johnston, J, Beth, M, Vlastaris, A, Kemp, S, Taheri, H, Pereira, E, Deyoung, M, Hawa, Z, Smith, R, Galski, T, Garas, S, Reddy, M, Sharma, S, Hargrove, J, Treasure, C, Emerson, R, 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T., Hsieh I. -C., Chen Z. -C., Lee M. -J., Chiang C., Shyu K. -G., Hsia C. -H., Mar G. -Y., Chan S. -H., Wu C. -C., Tseng W. -K., Chang K. -C., Yeh H. -I., Wang J. -H., Hou C., Sorokina I., Dolzhenko M., Horoshko O., Karpenko O., Rudenko L., Vakaliuk I., Kulyk A., Levchenko O., Prokhorov O., Reshotko D., Sorokivskyy M., Velichko N., Maslovskyi V., Teliatnikova Z., Dotsenko S., Krakhmalova O., Kraiz I., Zharinova V., Bula L., Kaydashev I., Molodtsov V., Rasputina L., Pidlisna V., Lysunets O., Kravchenko A., Glushko L., Khomazyuk T., Svyshchenko Y., Parkhomenko O., Mankovsky B., Abrahamovych O., Yagensky A., Stanislavchuk M., Vasilyeva L., Sokolova L., Sychov O., Tseluyko V., Kyrychenko I., Rishko M., Furkalo S., Gallo R., Bertrand O., Mehta S., Constance C., Sussex B., Zadra R., Kouz S., Chehayeb R., Pandey A., Dion D., Bailey G., Hill L., Ramanathan K., Dorsch M., Nanji A., Babapulle M., Montigny M., Gosselin G., Dehghani P., Rupka D., Le May M., Pichette F., St-Maurice F., Teefy P., Mansour S., Kassam S., Cheung S., Siega A. D., O'Keefe D., Sabbah E., Bell A., Chouinard G., Wong B., Miller M., Gaudet D., Lachance P., Bata I., Petrella R., Gossard D., Dumas R., Ing D., Boyrazian H., Bessoudo R., Huynh T. T., Hart R., Belle-Isle J., Shukla D., Kelly A., Mazza G., Cha J., Henein S., Frechette A., Vizel S., Liutkus J. F., O'Mahony M., Halperin F., Kooy J., Graham J., Bailey A., Wojcik R., Wilderman I., Turi T., Motyovszki A., Merkely B., Kiss R. G., Kiraly C., Andrassy P., Sarszegi Z., Fulop T., Zilahi Z., Edes I., Papp A., Muller G., Czigany A., Zolyomi S., Koranyi L., Takacs J., Juhasz F., Benczur B., Kancz S., Foldi A., Nagy A. 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C., Istratoaie O., Coman I., Militaru C., Cinteza M., Sinnaeve P. R., Nicolau J. C., Kerr Saraiva J. F., Widimsky P., Kristensen S. D., Hartikainen J., Darius H., Tse H. F., Pais P., Lev E., de Luca L., Ramos Lopez G. A., Kontny F., Babilonia N. A., Zateyshchikov D. A., Ruda M., Elamin O., Kovar F., Dalby A. J., Bueno H., Chiang C. -E., Parkhomenko A., Nguyen T. Q., and Leonsson-Zachrisson M.
Abstract: Background: Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor. Methods: The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population). Findings: Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, pinteraction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo
Published: 2019

11. Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation: The GLORIA-AF registry

Author: Ntaios, G., Huisman, M. V., Diener, H. -C., Halperin, J. L., Teutsch, C., Marler, S., Gurusamy, V. K., Thompson, M., Lip, G. Y. H., Olshansky, B., Abban, D. W., Abdul, N., Abud, A. M., Adams, F., Addala, S., Adragao, P., Ageno, W., Aggarwal, R., Agosti, S., Agostoni, P., Aguilar, F., Linares, J. A., Aguinaga, L., Ahmed, J., Aiello, A., Ainsworth, P., Aiub, J. R., Al-Dallow, R., Alderson, L., Aldrete Velasco, J. A., Alexopoulos, D., Manterola, F. A., Aliyar, P., Alonso, D., Alves da Costa, F. A., Amado, J., Amara, W., Amelot, M., Amjadi, N., Ammirati, F., Andrade, M., Andrawis, N., Annoni, G., Ansalone, G., Ariani, M. K., Arias, J. C., Armero, S., Arora, C., Aslam, M. S., Asselman, M., Audouin, P., Augenbraun, C., Aydin, S., Ayryanova, I., Aziz, E., Backes, L. M., Badings, E., Bagni, E., Baker, S. H., Bala, R., Baldi, A., Bando, S., Banerjee, S., Bank, A., Esquivias, G. B., Barr, C., Bartlett, M., Kes, V. B., Baula, G., Behrens, S., Bell, A., Benedetti, R., Mazuecos, J. B., Benhalima, B., Bergler-Klein, J., Berneau, J. -B., Bernstein, R. A., Berrospi, P., Berti, S., Berz, A., Best, E., Bettencourt, P., Betzu, R., Bhagwat, R., Bhatta, L., Biscione, F., Bisignani, G., Black, T., Bloch, M. J., Bloom, S., Blumberg, E., Bo, M., Bohmer, E., Bollmann, A., Bongiorni, M. G., Boriani, G., Boswijk, D. J., Bott, J., Bottacchi, E., Kalan, M. B., Bradman, D., Brautigam, D., Breton, N., Brouwers, P. J. A. M., Browne, K., Cortada, J. B., Bruni, A., Brunschwig, C., Buathier, H., Buhl, A., Bullinga, J., Cabrera, J. W., Caccavo, A., Cai, S., Caine, S., Calo, L., Calvi, V., Sanchez, M. C., Candeias, R., Capuano, V., Capucci, A., Caputo, R., Rizo, T. C., Cardona, F., Carlos da Costa Darrieux, F., Duarte Vera, Y. C., Carolei, A., Carreno, S., Carvalho, P., Cary, S., Casu, G., Cavallini, C., Cayla, G., Celentano, A., Cha, T. -J., Cha, K. S., Chae, J. K., Chalamidas, K., Challappa, K., Chand, S. P., Chandrashekar, H., Chartier, L., Chatterjee, K., Chavez Ayala, C. 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E., Higashino, Y., Hill, M., Hisadome, T., Hishida, E., Hoffer, E., Hoghton, M., Hong, K., Hong, S. K., Horbach, S., Horiuchi, M., Hou, Y., Hsing, J., Huang, C. -H., Huckins, D., Kathy, Hughe, Huizinga, A., Hulsman, E. L., Hung, K. -C., Hwang, G. -S., Ikpoh, M., Imberti, D., Ince, H., Indolfi, C., Inoue, S., Irles, D., Iseki, H., Israel, C. N., Iteld, B., Iyer, V., Jackson-Voyzey, E., Jaffrani, N., Jager, F., James, M., Jang, S. -W., Jaramillo, N., Jarmukli, N., Jeanfreau, R. J., Jenkins, R. D., Sanchez, C. J., Jimenez, J., Jobe, R., Joen-Jakobsen, T., Jones, N., Moura Jorge, J. C., Jouve, B., Jung, B. C., Jung, K. T., Jung, W., Kachkovskiy, M., Kafkala, K., Kalinina, L., Kallmunzer, B., Kamali, F., Kamo, T., Kampus, P., Kashou, H., Kastrup, A., Katsivas, A., Kaufman, E., Kawai, K., Kawajiri, K., Kazmierski, J. F., Keeling, P., Kerr Saraiva, J. F., Ketova, G., Khaira, A. S., Khripun, A., Kim, D. -I., Kim, Y. H., Kim, N. H., Kim, D. K., Kim, J. S., Kim, K. S., Kim, J. B., Kinova, E., Klein, A., Kmetzo, J. J., Kneller, G. L., Knezevic, A., Angela Koh, S. M., Koide, S., Kollias, A., Kooistra, J. A., Koons, J., Koschutnik, M., Kostis, W. J., Kovacic, D., Kowalczyk, J., Koziolova, N., Kraft, P., Kragten, J. A., Krantz, M., Krause, L., Krenning, B. J., Krikke, F., Kromhout, Z., Krysiak, W., Kumar, P., Kumler, T., Kuniss, M., Kuo, J. -Y., Kuppers, A., Kurrelmeyer, K., Kwak, C. H., Laboulle, B., Labovitz, A., Lai, W. T., Lam, A., Lam, Y. Y., Zanetti, F. L., Landau, C., Landini, G., Figueiredo, E. L., Larsen, T., Lavandier, K., Leblanc, J., Lee, M. H., Lee, C. -H., Lehman, J., Leitao, A., Lellouche, N., Lelonek, M., Lenarczyk, R., Lenderink, T., Gonzalez, S. L., Leong-Sit, P., Leschke, M., Ley, N., Li, Z., Li, X., Li, W., Lichy, C., Lieber, I., Limon Rodriguez, R. H., Lin, H., Liu, F., Liu, H., Esperon, G. L., Navarro, N. L., Lo, E., Lokshyn, S., Lopez, A., Lopez-Sendon, J. L., Lorga Filho, A. M., Lorraine, R. S., Luengas, C. 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S., Paparella, G., Paris, F., Park, H. W., Park, J. S., Parthenakis, F., Passamonti, E., Patel, R. J., Patel, J., Patel, M., Patrick, J., Jimenez, R. P., Paz, A., Pengo, V., Pentz, W., Perez, B., Perez Rios, A. M., Perez-Cabezas, A., Perlman, R., Persic, V., Perticone, F., Peters, T. K., Petkar, S., Pezo, L. F., Pflucke, C., Pham, D. N., Phillips, R. T., Phlaum, S., Pieters, D., Pineau, J., Pinter, A., Pinto, F., Pisters, R., Pivac, N., Pocanic, D., Podoleanu, C., Politano, A., Poljakovic, Z., Pollock, S., Garcea, J. P., Poppert, H., Porcu, M., Reino, A. P., Prasad, N., Precoma, D. B., Prelle, A., Prodafikas, J., Protasov, K., Pye, M., Qiu, Z., Quedillac, J. -M., Raev, D., Raffo Grado, C. A., Rahimi, S., Raisaro, A., Rama, B., Ramos, R., Ranieri, M., Raposo, N., Rashba, E., Rauch-Kroehnert, U., Reddy, R., Renda, G., Reza, S., Ria, L., Richter, D., Rickli, H., Rieker, W., Vera, T. R., Ritt, L. E., Roberts, D., Briones, I. R., Rodriguez Escudero, A. E., Pascual, C. R., Roman, M., Romeo, F., Ronner, E., Roux, J. -F., Rozkova, N., Rubacek, M., Rubalcava, F., Russo, A. M., Rutgers, M. P., Rybak, K., Said, S., Sakamoto, T., Salacata, A., Salem, A., Bodes, R. S., Saltzman, M. A., Salvioni, A., Vallejo, G. S., Fernandez, M. S., Saporito, W. F., Sarikonda, K., Sasaoka, T., Sati, H., Savelieva, I., Scala, P. -J., Schellinger, P., Scherr, C., Schmitz, L., Schmitz, K. -H., Schmitz, B., Schnabel, T., Schnupp, S., Schoeniger, P., Schon, N., Schwimmbeck, P., Seamark, C., Searles, G., Seidl, K. -H., Seidman, B., Sek, J., Sekaran, L., Serrati, C., Shah, N., Shah, V., Shah, A., Shah, S., Sharma, V. K., Shaw, L., Sheikh, K. H., Shimizu, N., Shimomura, H., Shin, D. -G., Shin, E. -S., Shite, J., Sibilio, G., Silver, F., Sime, I., Simmers, T. A., Singh, N., Siostrzonek, P., Smadja, D., Smith, D. W., Snitman, M., Filho, D. S., Soda, H., Sofley, C., Sokal, A., Oi Yan, Y. S., Sotolongo, R., Ferreira de Souza, O., Sparby, J. A., Spinar, J., Sprigings, D., Spyropoulos, A. C., Stakos, D., Steinwender, C., Stergiou, G., Stiell, I., Stoddard, M., Stoikov, A., Streb, W., Styliadis, I., Su, G., Su, X., Sudnik, W., Sukles, K., Sun, X., Swart, H., Szavits-Nossan, J., Taggeselle, J., Takagi, Y., Singh Takhar, A. P., Tamm, A., Tanaka, K., Tanawuttiwat, T., Tang, S., Tang, A., Tarsi, G., Tassinari, T., Tayal, A., Tayebjee, M., Berg, J. M. T., Tesloianu, D., The, S. H. K., Thomas, D., Timsit, S., Tobaru, T., Tomasik, A. R., Torosoff, M., Touze, E., Trendafilova, E., Tsai, W. K., Tse, H. F., Tsutsui, H., Tu, T. M., Tuininga, Y., Turakhia, M., Turk, S., Tcurner, W., Tveit, A., Tytus, R., Valadao, C., van Bergen, P. F. M. M., van de Borne, P., van den Berg, B. J., van der Zwaan, C., Van Eck, M., Vanacker, P., Vasilev, D., Vasilikos, V., Vasilyev, M., Veerareddy, S., Mino, M. V., Venkataraman, A., Verdecchia, P., Versaci, F., Vester, E. G., Vial, H., Victory, J., Villamil, A., Vincent, M., Vlastaris, A., Dahl, J. V., Vora, K., Vranian, R. B., Wakefield, P., Wang, N., Wang, M., Wang, X., Wang, F., Wang, T., Warner, A. L., Watanabe, K., Wei, J., Weimar, C., Weiner, S., Weinrich, R., Wen, M. -S., Wiemer, M., Wiggers, P., Wilke, A., Williams, D., Williams, M. L., Witzenbichler, B., Wong, B., Lawrence Wong, K. S., Wozakowska-Kaplon, B., Wu, S., Wu, R. C., Wunderlich, S., Wyatt, N., Wylie, J. J., Xu, Y., Xu, X., Yamanoue, H., Yamashita, T., Bryan Yan, P. Y., Yang, T., Yao, J., Yeh, K. -H., Yin, W. H., Yotov, Y., Zahn, R., Zarich, S., Zenin, S., Zeuthen, E. L., Zhang, H., Zhang, D., Zhang, X., Zhang, P., Zhang, J., Zhao, S. P., Zhao, Y., Zhao, Z., Zheng, Y., Zhou, J., Zimmermann, S., Zini, A., Zizzo, S., Zong, W., Zukerman, L. S., and Crea F. (ORCID:0000-0001-9404-8846)
Abstract: Aim: The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2 scores >2 than to patients with lower scores. Methods and results: We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF), a large, global, prospective global registry of patients with newly diagnosed AF and ≥1 stroke risk factor. We compared baseline clinical characteristics and antithrombotic prescriptions to determine the probability of the VKA prescription among anticoagulated patients with the baseline SAMe-TT2R2 score >2 and ≤ 2. Among 17,465 anticoagulated patients with AF, 4,828 (27.6%) patients were prescribed VKA and 12,637 (72.4%) patients an NOAC: 11,884 (68.0%) patients had SAMe-TT2R2 scores 0-2 and 5,581 (32.0%) patients had scores >2. The proportion of patients prescribed VKA was 28.0% among patients with SAMe-TT2R2 scores >2 and 27.5% in those with scores ≤2. Conclusions: The lack of a clear association between the SAMe-TT2R2 score and anticoagulant selection may be attributed to the relative efficacy and safety profiles between NOACs and VKAs as well as to the absence of trial evidence that an SAMe-TT2R2-guided strategy for the selection of the type of anticoagulation in NVAF patients has an impact on clinical outcomes of efficacy and safety. The latter hypothesis is currently being tested in a randomized controlled trial. Clinical trial registration: URL: https://www.clinicaltrials.gov//Unique identifier: NCT01937377, NCT01468701, and NCT01671007.
Published: 2021

12. Factors Associated With Large Improvements in Health-Related Quality of Life in Patients With Atrial Fibrillation

Author: Steinberg, Benjamin A., primary, Holmes, DaJuanicia N., additional, Pieper, Karen, additional, Allen, Larry A., additional, Chan, Paul S., additional, Ezekowitz, Michael D., additional, Freeman, James V., additional, Fonarow, Gregg C., additional, Gersh, Bernard J., additional, Hylek, Elaine M., additional, Kowey, Peter R., additional, Mahaffey, Kenneth W., additional, Naccarelli, Gerald, additional, Reiffel, James, additional, Singer, Daniel E., additional, Peterson, Eric D., additional, Piccini, Jonathan P., additional, Mendelson, R., additional, Nahhas, A., additional, Neutel, J., additional, Padanilam, B., additional, Pan, D., additional, Poock, J., additional, Raffetto, J., additional, Greengold, R., additional, Roan, P., additional, Saba, F., additional, Sackett, M., additional, Schneider, R., additional, Seymour, Z., additional, Shanes, J., additional, Shoemaker, J., additional, Simms, V., additional, Smiley, N., additional, Smith, D., additional, Snipes, C., additional, Sotolongo, R., additional, Staniloae, C., additional, Stoltz, S., additional, Suresh, D.P., additional, Tak, T., additional, Tannenbaum, A., additional, Turk, S., additional, Vora, K., additional, Randhawa, P., additional, Zebrack, J., additional, Silva, E., additional, Riley, E., additional, Weinstein, D., additional, Vasiliauskas, T., additional, Goldbarg, S., additional, Hayward, D., additional, Yarlagadda, C., additional, Laurion, D., additional, Osunkoya, A., additional, Burns, R., additional, Castor, T., additional, Spiller, D., additional, Luttman, C., additional, Anton, S., additional, McGarvey, J., additional, Guthrie, R., additional, Deriso, G., additional, Flood, R., additional, Fleischer, L., additional, Fierstein, J.S., additional, Aggarwal, R., additional, Jacobs, G., additional, Adjei, N., additional, Akyea-Djamson, A., additional, Alfieri, A., additional, Bacon, J., additional, Bedwell, N., additional, Berger, P., additional, Berry, J., additional, Bhagwat, R., additional, Bloom, S., additional, Boccalandro, F., additional, Capo, J., additional, Kapadia, S., additional, Casanova, R., additional, Morriss III, J.E., additional, Christensen, T., additional, Elsen, J., additional, Farsad, R., additional, Fox, D., additional, Frandsen, B., additional, Gelernt, M., additional, Gill, S., additional, Grubb, S., additional, Hall, C., additional, Harris, H., additional, Hotchkiss, D., additional, Ip, J., additional, Jaffrani, N., additional, Jones, A., additional, Kazmierski, J., additional, Waxman, F., additional, Kneller, G.L., additional, Labroo, A., additional, Jaffe, B., additional, Lebenthal, M., additional, Lee, D., additional, Lillestol, M., additional, LeClerc, K., additional, Maccaro, P., additional, Mayer, N., additional, Kozlowski, J., additional, Benjamin, S., additional, Detweiler, R., additional, Igic, P., additional, Jackson, T., additional, Pappas, J., additional, Littlefield, R., additional, Frey, A., additional, Vranian, R., additional, Long, W., additional, Grena, P., additional, Arouni, A., additional, Quinn, J., additional, Browne, K., additional, Forman, S., additional, Ebinger, M., additional, Blonder, R., additional, Snyder, H., additional, Slabic, S., additional, Williams, D., additional, Stein, R., additional, Kirkland, S., additional, Cohen, K., additional, Walthall, W., additional, Davis, K., additional, Snoddy, B., additional, Alvarado, O., additional, Leach, C., additional, Rothman, S., additional, Sharma, A., additional, Olatidoye, A., additional, AlMahameed, S., additional, Rosenthal, S., additional, Sutter, G., additional, Reiter, W., additional, Thompson, T., additional, Thew, S., additional, Kobayashi, J., additional, Williams, M., additional, Kramer, J., additional, Latif, S.A., additional, Rhee, B., additional, Adler, A., additional, Ruiz-Serrano, D., additional, Stringam, S., additional, Wolok, K., additional, Focil, A., additional, Butman, S., additional, Ingersoll, H., additional, Borge, R., additional, Al-Saghir, Y., additional, Coats, P., additional, Farris, N., additional, Shore, K., additional, Schwartz, M.B., additional, Gornick, C., additional, Eilat, P., additional, Quinlan, E., additional, Paliwal, Y., additional, Mitra, R., additional, Jingo, A., additional, Aslam, A.A., additional, Watson, R., additional, Voyce, S., additional, Turakhia, M., additional, Goytia-Leos, D., additional, Lurie, M., additional, Mallis, G., additional, Atwater, B., additional, Strobel, J., additional, Murray, J., additional, Fisher, D., additional, Atieh, M., additional, Landes, R., additional, Drabick, A., additional, Harman, E., additional, Ashcraft, B., additional, Krista, M., additional, Videlefsky, A., additional, Rivera Zayas, E., additional, and Tan, A.E., additional
Published: 2020
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13. The Changing Landscape for Stroke Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Author: Huisman, M. V., Rothman, K. J., Paquette, M., Teutsch, C., Diener, H. -C., Dubner, S. J., Halperin, J. L., C. S., Ma, Zint, K., Elsaesser, A., Bartels, D. B., Lip, G. Y. H., Abban, D., Abdul, N., Abelson, M., Ackermann, A., Adams, F., Adams, L., Adragao, P., Ageno, W., Aggarwal, R., Agosti, S., Marin, J. A., Aguilar, F., Aguilar Linares, J. A., Aguinaga, L., Ahmad, Z., Ainsworth, P., Al Ghalayini, K., Al Ismail, S., Alasfar, A., Alawwa, A., Al-Dallow, R., Alderson, L., Alexopoulos, D., Ali, A., Ali, M., Aliyar, P., Al-Joundi, T., Al Mahameed, S., Almassi, H., Almuti, K., Al-Obaidi, M., Alshehri, M., Altmann, U., Alves, A. R., Al-Zoebi, A., Amara, W., Amelot, M., Amjadi, N., Ammirati, F., Andrawis, N., Angoulvant, D., Annoni, G., Ansalone, G., Antonescu, S. A., Ariani, M., Arias, J. C., Armero, S., Arora, R., Arora, C., Ashcraft, W., Aslam, M. S., Astesiano, A., Audouin, P., Augenbraun, C., Aydin, S., Azar, R., Azim, A., Aziz, S., Backes, L. M., Baig, M., Bains, S., Bakbak, A., Baker, S., Bakhtiar, K., Bala, R., Banayan, J., Bandh, S., Bando, S., Banerjee, S., Bank, A., Barbarash, O., Baron, G., Barr, C., Barrera, C., Barton, J., Kes, V. B., Baula, G., Bayeh, H., Bazargani, N., Behrens, S., Bell, A., Benezet-Mazuecos, J., Benhalima, B., Berdague, P., Berg van den, B. J., Bergen van, P. F. M. M., Berngard, E., Bernstein, R., Berrospi, P., Berti, S., Bertomeu, V., Berz, A., Bettencourt, P., Betzu, R., Beyer-Westendorf, J., Bhagwat, R., Black, T., Blanco Ibaceta, J. H., Bloom, S., Blumberg, E., Bo, M., Bockisch, V., Bohmer, E., Bongiorni, M. G., Boriani, G., Bosch, R., Boswijk, D. J., Bott, J., Bottacchi, E., Kalan, M. B., Brandes, A., Bratland, B., Brautigam, D., Breton, N., Brouwers, P. J. A. M., Browne, K., Bruguera, J., Brunehaut, M., Brunschwig, C., Buathier, H., Buhl, A., Bullinga, J., Butcher, K., Cabrera Honorio, J. W., Caccavo, A., Cadinot, D., Cai, S., Calvi, V., Camm, J., Candeias, R., Capo, J., Capucci, A., Cardoso, J. N., Duarte Vera, Y. C., Carlson, B., Carvalho, P., Cary, S., Casanova, R., Casu, G., Cattan, S., Cavallini, C., Cayla, G., Cha, T. J., Cha, K. S., Chaaban, S., Chae, J. K., Challappa, K., Chand, S., Chandrashekar, H., Chang, M., Charbel, P., Chartier, L., Chatterjee, K., Cheema, A., Chen, S. -A., Chevallereau, P., Chiang, F. -T., Chiarella, F., Chih-Chan, L., Cho, Y. K., Choi, D. J., Chouinard, G., Danny, Chow, H. F., Chrysos, D., Chumakova, G., Jose Roberto Chuquiure Valenzuela, E. J., Cieza-Lara, T., Nica, V. C., Ciobotaru, V., Cislowski, D., Citerne, O., Claus, M., Clay, A., Clifford, P., Cohen, S., Cohen, A., Colivicchi, F., Collins, R., Compton, S., Connors, S., Conti, A., Buenostro, G. C., Coodley, G., Cooper, M., Corbett, L., Corey, O., Coronel, J., Corrigan, J., Cotrina Pereyra, R. Y., Cottin, Y., Coutu, B., Cracan, A., Crean, P., Crenshaw, J., Crijns, H. J. G. M., Crump, C., Cucher, F., Cudmore, D., Cui, L., Culp, J., Darius, H., Dary, P., Dascotte, O., Dauber, I., Davee, T., Davies, R., Davis, G., Davy, J. -M., Dayer, M., De La Briolle, A., de Mora, M., De Teresa, E., De Wolf, L., Decoulx, E., Deepak, S., Defaye, P., Del-Carpio Munoz, F., Brkljacic, D. D., Deluche, L., Destrac, S., Deumite, N. J., Di Legge, S., Dibon, O., Diemberger, I., Dillinger, J., Dionisio, P., Naydenov, S., Dotani, I., Dotcheva, E., D'Souza, A., Dubrey, S., Ducrocq, X., Dupljakov, D., Duthinh, V., Dutra, O. P., Dutta, D., Duvilla, N., Dy, J., Dziewas, R., Eaton, C., Eaves, W., Ebinger, M., Eck van, J. W. M., Edwards, T., Egocheaga, I., Ehrlich, C., Eisenberg, S., El Hallak, A., El Jabali, A., El Mahmoud, R., El Shahawy, M., Eldadah, Z., Elghelbazouri, F., Elhag, O., El-Hamdani, M., Elias, D., Ellery, A., El-Sayed, H., Elvan, A., Erickson, B., Espaliat, E., Essandoh, L., Everington, T., Evonich, R., Ezhov, A., Facila, L., Farsad, R., Fayard, M., Fedele, F., Gomes Ferreira, L. G., Ferreira, D., Santos, J. F., Ferrier, A., Finsen, A., First, B., Fisher, R., Floyd, J., Folk, T., Fonseca, C., Fonseca, L., Forman, S., Forsgren, M., Foster, M., Foster, N., Frais, M., Frandsen, B., Frappe, T., Freixa, R., French, W., Freydlin, M., Frickel, S., Fruntelata, A. G., Fujii, S., Fujino, Y., Fukunaga, H., Furukawa, Y., Gabelmann, M., Gabris, M., Gadsboll, N., Galin, P., Galinier, M., Ganim, R., Garcia, R., Quintana, A. G., Gartenlaub, O., Genz, C., Georger, F., Georges, J. -L., Georgeson, S., Ghanbasha, A., Giedrimas, E., Gierba, M., Gillespie, E., Giniger, A., Gkotsis, A., Gmehling, J., Gniot, J., Goethals, P., Goldberg, R., Goldmann, B., Goldscher, D., Golitsyn, S., Gomez Lopez, E. A., Gomez Mesa, J. E., Gonzalez, E., Cocina, E. G., Juanatey, C. G., Gorbunov, V., Gordon, B., Gorka, H., Gornick, C., Gorog, D., Goss, F., Gotte, A., Goube, P., Goudevenos, I., Goulden, D., Graham, B., Grande, A., Greco, C., Green, M., Greer, G., Gremmler, U., Grena, P., Grinshstein, Y., Grond, M., Gronda, E., Grondin, F., Gronefeld, G., Groot de, J. R., Guardigli, G., Guarnieri, T., Caiedo, C. G., Guignier, A., Gulizia, M., Gumbley, M., Gupta, D., Hack, T., Haerer, W., Hakas, J., Hall, C., Hampsey, J., Hananis, G., Hanbali, B., Handel, F., Hargrove, J., Hargroves, D., Harris, K., Hartley, D., Haruna, T., Hata, Y., Hayek, E., Healey, J., Hearne, S., Heggelund, G., Hemels, M. E. W., Hemery, Y., Henein, S., Henz, B., Her, S. -H., Hermany, P., Hernandes, M. E., Higashino, Y., Hill, M., Hisadome, T., Hishida, E., Hitchcock, J., Hoffer, E., Hoghton, M., Holmes, C., Hong, S. K., Houppe Nousse, M. -P., Howard, V., Hsu, L. F., Huang, C. -H., Huckins, D., Huehnergarth, K., Huizenga, A., Huntley, R., Hussein, G., Hwang, G. -S., Igbokidi, O., Iglesias, I., Ikpoh, M., Imberti, D., Ince, H., Indolfi, C., Ionova, T., Ip, J., Irles, D., Iseki, H., Ismail, Y., Israel, N., Isserman, S., Iteld, B., Ivanchura, G., Iyer, R., Iyer, V., Iza Villanueva, R. O., Jackson-Voyzey, E., Jaffrani, N., Jager, F., Jain, M., James, M., Jamon, Y., Jang, S. W., Pereira Jardim, C. A., Jarmukli, N., Jeanfreau, R., Jenkins, R., Jiang, X., Jiang, H., Jiang, T., Jiang, N., Jimenez, J., Jobe, R., Joffe, I., Johansson, B., Jones, N., Moura Jorge, J. C., Jouve, B., Jundi, M., Jung, W., Jung, B. C., Jung, K. T., Kabbani, S., Kabour, A., Kafkala, C., Kajiwara, K., Kalinina, L., Kampus, P., Kanda, J., Kapadia, S., Karim, A., Karolyi, L., Kashou, H., Kastrup, A., Katsivas, A., Kaufman, E., Kawai, K., Kawajiri, K., Kazmierski, J., Keeling, P., Kerfes, G. A., Kerr Saraiva, J. F., Ketova, G., Khaira, A., Khalid, M., Khludeeva, E., Khripun, A., Kim, D. I., Kim, D. K., Kim, N. H., Kim, K. S., Kim, Y. -H., Kim, J. B., Kim, J. S., Kinova, E., Klein, A., Kleinschnitz, C., Kmetzo, J., Kneller, G. L., Knezevic, A., Koch, S., Koenig, K., Angela Koh, S. M., Kohrmann, M., Koons, J., Korabathina, R., Korennova, O., Koschutnik, M., Kosinski, E., Kovacic, D., Kowalczyk, J., Koziolova, N., Kragten, J. A., Krause, L. U., Kreidieh, I., Krenning, B. J., Krishnaswamy, K., Krysiak, W., Kuck, K. -H., Kumar, S., Kumler, T., Kuniss, M., Kuo, J. -Y., Kuppers, A., Kurrelmeyer, K., Kwan, T., Kyo, E., Labovitz, A., Lacroix, A., Lam, A., Lanas Zanetti, F. T., Landau, C., Landini, G., Lang, W., Larsen, T. B., Laske, V., Lavandier, K., Law, N., Lee, M. H., Lee, D., Leitao, A., Lejay, D., Lelonek, M., Lenarczyk, R., Leprince, P., Lequeux, B., Leschke, M., Ley, N., Li, Z., Li, Y., Li, X., Li, W., Liang, J., Lieber, I., Lillestol, M., Limon Rodriguez, R. H., Lin, H., Lip, G., Litchfield, J., Liu, Z., Liu, X., Liu, Y., Liu, F., Liu, W., Llamas Esperon, G. A., Llisterri, J. L., Lo, T., Lo, E., Lobos, J. M., Lodde, B. -P., Loiselet, P., Lopez-Sendon, J., Lorga Filho, A. M., Lori, I., Luo, M., Lupovitch, S., Lyrer, P., Zuhairy, H. M., Ma, C., Ma, G., Ma, H., Madariaga, I., Maeno, K., Magnin, D., Mahmood, S., Mahood, K., Maid, G., Mainigi, S., Makaritsis, K., Maldonado Villalon, J. A., Malhotra, R., Malik, A., Mallecourt, C., Mallik, R., Manning, R., Manolis, A., Mantas, I., Manzur Jattin, F. G., Marcionni, N., Marin, F., Santana, A. M., Martinez, J., Martinez, L., Maskova, P., Hernandez, N. 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H, Tsutsui, T, Tuininga, Y, Turakhia, M, Turk, S, Turner, W, Tveit, A, Twiddy, S, Tytus, R, Ukrainski, G, Valdovinos Chavez, S, Van De Graaff, E, Vanacker, P, Vardas, P, Vargas, M, Vassilikos, V, Vazquez, J, Venkataraman, A, Verdecchia, P, Vester, E, Vial, H, Vinereanu, D, Vlastaris, A, Vogel, C, vom Dahl, J, von Mering, M, Vora, K, Wakefield, P, Walia, J, Walter, T, Wang, M, Wang, N, Wang, F, Wang, X, Wang, Z, Wang, K, Watanabe, K, Wei, J, Weimar, C, Weinrich, R, Wen, M, Wheelan, K, Wicke, J, Wiemer, M, Wild, B, Wilke, A, Willems, S, Williams, M, Williams, D, Winkler, A, Wirtz, J, Witzenbichler, B, Wong, D, Lawrence Wong, K, Wong, B, Wozakowska Kaplon, B, Wu, Z, Wu, S, Wyatt, N, Xu, Y, Xu, X, Yamada, A, Yamamoto, K, Yamanoue, H, Yamashita, T, Bryan Yan, P, Yang, Y, Yang, T, Yao, J, Yarlagadda, C, Yeh, K, Yotov, Y, Yvorra, S, Zahn, R, Zamorano, J, Zanini, R, Zarich, S, Zebrack, J, Zenin, S, Zeuthen, E, Zhang, X, Zhang, Q, Zhang, D, Zhang, H, Zhao, S, Zhao, X, Zheng, Y, Zheng, Q, Zhou, J, Zimmermann, S, Zimmermann, R, Zukerman, L, and Zwaan van der, C
Subjects: Male, oral anticoagulation, Internationality, Middle Aged, registry, Antithrombins, Dabigatran, Stroke, Cross-Sectional Studies, Fibrinolytic Agents, Humans, Female, atrial fibrillation, Prospective Studies, Registries, Cardiology and Cardiovascular Medicine, Aged, Atrial Fibrillation
Abstract: Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non–vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients’ baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score ≥2; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701)
Published: 2017

14. Ertugliflozin and Slope of Chronic eGFR

Author: Cherney, David Z.I., Cosentino, Francesco, Dagogo-Jack, Samuel, McGuire, Darren K., Pratley, Richard, Frederich, Robert, Maldonado, Mario, Liu, Chih-Chin, Liu, Jie, Pong, Annpey, Cannon, Christopher P., Pozzi, Jose Maria, Maffei, Laura, Nardone, Lucrecia, Sessa, Horacio, Brasca, Daniela Garcia, Aizenberg, Diego, Baccaro, Claudia Emilce, Gelersztein, Elizabeth Silvana, Rosario, Fabian Calella Pedro, Leon de la Fuente, Ricardo, de Lapertosa, Silvia Gorban, Maldonado, Natacha, Cruciani, Adrian, Bartolacci, Ines, Hasbani, Eduardo, Frechtel, Gustavo, Papini, Nelson Rodriguez, Pereyra, Alejandro, Montana, Oscar, Zaidman, Cesar, Mansilla, Maria, Ayres, Bronte, Simpson, Richard, Glastras, Sarah, William, Maged, Davis, Timothy, Colquhoun, David, Proietto, Joseph, Roberts, Adam, Roberts, Anthony, Stuckey, Bronwyn, Wittert, Gary, Soldatos, Georgia, Vora, Parind, Kusljugic, Zumreta, Avdagic, Azra, Durak-Nalbantic, Azra, Ibrahimpasic, Kanita, Horozic, Bosanko, Spuzic, Muhamed, Soldat-Stankovic, Valentina, Stevanovic, Dragan, Koco, Damir, Jatic, Zaim, Terzic, Ibrahim, Potkonjak, Ljiljana Markovic, Prnjavorac, Besim, Radanovic, Aleksandar, Salihbasic, Muhamed, Dimitrov, Dimitar, Stoikov, Anastas, Damyanova, Velichka, Vasileva, Darina, Kirilov, Kiril, Lefterov, Ivailo, Lyubenova, Lyudmila, Raev, Dimitar, Tsanova, Veska, Mitkov, Mitko, Shumkova, Rositsa, Kichukov, Kostadin, Simeonova-Nikolova, Tatyana, Ekoe, Jean-Marie, Pandey, Shekhar A., Dumas, Richard, Woo, Vincent, Saunders, Kevin, Conway, James, Breger, Laurie, Constance, Christian, O'Mahony, Michael, Perron, Patrice, Garceau, Claude, Csanadi, Michael, Bourgeois, Ronald, Salter, Timothy, Frechette, Andre, Diaz, Ariel, Ransom, Thomas, Sanchez-Vallejo, Gregorio, Silva, Sandra Isabel Barrera, Mendoza, Jose Accini, Ortiz, Luis Garcia, Lozno, Hernan Yupanqui, de Salazar, Dora Molina, Arroyo, Julian Coronel, Orozco Linares, Luis Alejandro, Lenis Rendon, Claudia Patricia, Darko, Pocanic, Tusek, Srecko, Weiss, Sonja Slosic, Silvija, Canecki-Varzic, Velimir, Altabas, Sidbela, Zukanovic, Cikac, Tatjana, Vucak, Jasna, Cenan, Ljiljana, Boljkovac, Zrinka, Margetic, Srecko, Kranjcevic, Ksenija, Cop, Renata, Adamkova, Vera, Pavlina, Kyselova, Wasserburger, Bedrich, Hrdina, Tomas, Smolenakova, Katerina, Ketevan, Chagunava, Pagava, Zurab, Mamatsashvili, Merab, Burnadze, Koba, Chumburidze, Vakhtang, Lominadze, Zaza, Nikoleishvili, Lali, Kobulia, Bondo, Koberidze, Nana, Emukhvari, Nodar, Kipiani, Zviad, Metreveli, David, Glonti, Salome, Giorgadze, Elene, Shaburishvili, Tamaz, Chapidze, Gulnara, Gulua, Julieta, Gogorishvili, Irakli, Berukashvili, Ekaterine, Petriashvili, Shalva, Kurashvili, Givi, Elisaf, Moses, Bousboulas, Stavros, Tentolouris, Nikolaos, Tsioufis, Konstantinos, Lymperi, Sotiria, Luk, Andrea, Yiu, Kelvin Kai Hang, Tsang, Chiu Chi, Yeung, Vincent Tok Fai, Lee, Alex Pui-Wai, Tan, Kathryn Choon Beng, Wan Ma, Ronald Ching, Wudi, Krisztina Beatrix, Bujtor, Zoltan, Feher, Zsuzsanna, Koranyi, Laszlo, Paragh, Gyorgy, Vasas, Szilard, Pauker, Zsolt, Kesmarki, Nora, Takacs, Janos, Nagy, Laszlo, Salamon, Csaba, Papp, Zsuzsanna, Hajdu, Csaba, Abramov, Galina, Hussein, Osamah, Vishlitzky, Victor, Dicker, Dror, Darawsha, Mahmud, Itzhak, Baruch, Gavish, Dov, Wainstein, Julio, Lewis, Basil, Klainman, Eliezer, Katz, Amos, Elias, Mazen, Ness-Abramof, Rosane, Hayek, Tony, Orsi, Emanuela, Lembo, Giuseppe, Piatti, Piermarco, Consoli, Agostino, Berti, Sergio, Pugliese, Giuseppe, Derosa, Giuseppe, Paolisso, Giuseppe, Limone, Paolo Piero, Jang, Hak Chul, Lee, Moon-Kyu, Kim, Nam Hoon, Cha, Bong-Soo, Park, Kyong Soo, Yoon, Kun Ho, Ahn, Chul Woo, Lee, Kwan Woo, Baik, Sei Hyun, Pirags, Valdis, Pastare, Sigita, Kavaliauskiene, Jurate, Augusteniene, Audrone, Navickas, Antanas, Urbanavicius, Vaidotas, Kavaliauskiene, Roma, Sirutaviciene, Ausra, Llamas Esperon, Guillermo Antonio, Mesa, Juan Villagordoa, Garcia Hernandez, Pedro Alberto, Ceballos, Rosa Luna, Salinas, Carlos Aguilar, Galvez, Guillermo Gonzalez, Melendez-Mier, Guillermo, Orozco, Raul Aguilar, Crijns, Harry, Hoogenberg, Klaas, Voors-Pette, Christine, Lunt, Helen, Scott, Russell, Baker, John, Williams, Michael, Kerr, Jane Elizabeth, Denopol, Marian, Panelo, Araceli, Tirador, Louie, Aquitania, Grace, Rogelio, Gregorio, Amorado-Santos, Florence, Habaluyas, Ramoncito, Rosa, Allyn Sy, Palomares, Ellen, Ebo, Geraldine, Romero, Chela Marie, Gladczak, Joanna, Hawryluk, Jaroslaw, Franek, Edward, Lukaszewicz, Monika, Madej-Dmochowska, Aleksandra, Jeznach-Steinhagen, Anna, Sokolowski, Grzegorz, Ruxer, Jan, Karczmarczyk, Agnieszka, Krzyzagorska, Ewa, Wozniak, Iwona, Olech-Cudzik, Anna, Dwojak, Marek, Anand, Izabela, Strojek, Krzysztof, Czernecka, Ewa, Antkowiak-Piatyszek, Karolina, Rozanska, Aleksandra, Gadzinski, Waldemar, Mader, Piotr, Kuligowska-jakubowska, Monika, Arciszewska, Malgorzata, Stankiewicz, Andrzej, Cypryk, Katarzyna, Wittek, Andrzej, Sawer-Szewczyk, Joanna, Pieniazek, Adam, Negrisanu, Gabriela, Pletea, Noemi, Zaharie, Daniela, Pintilei, Ella, Cif, Adriana, Duma, Livia, Szilagyi, Iosif, Halmagyi, Ildiko, Morosanu, Magdalena, Munteanu, Mircea, Albota, Adrian, Popescu, Alexandrina, Enculescu, Dan Anton, Hancu, Nicolae, Nafornita, Valerica, Croitoru, Lacramioara, Sebestyen, Lucia Luana, Pavlysh, Elena, Nikolaev, Konstantin, Vishnevsky, Alexandr, Reshetko, Olga, Kvitkova, Liudmila, Barbarash, Olga, Rodionova, Tatiana, Shaydyuk, Oxana, Ershova, Olga, Chizhov, Petr, Berns, Svetlana, Rechkova, Elena, Yakushin, Sergey, Zanozina, Olga, Lukyanov, Yuri, Vorobeva, Elena, Zateyshchikov, Dmitry, Verbovaya, Nelly, Bolshakova, Olga, Khrustalev, Oleg, Strongin, Leonid, Bondar, Irina, Zalevskaya, Alsu, Filippova, Ekaterina, Chumakova, Galina, Repin, Alexey, Panov, Alexey, Zivkovic, Teodora Beljic, Petakov, Milan, Sumarac-Dumanovic, Mirjana, Brankovic, Georgina Pudar, Kendereski, Aleksandra, Stojic, Stevo, Macut, Djuro, Babikova, Jana, Teplanova, Miriam, Tomasova, Livia, Martinka, Emil, Lachova, Beata, Ivancova, Gabriela, Rociakova, Jana, Schroner, Zbynek, Donicova, Viera, Ilavska, Adriana, Raslova, Katarina, Africa, South, Distiller, Lawrence, Siebert, Heidi, Badat, Aysha, Blignaut, Suzanne, Sarvan, Mahomed, Govender, Thirumani, Gani, Mashra, Nortje, Hendrik, Mookadam, Mohamed, Naiker, Puvanesveri, de Jong, Douwe, Van Zyl, Louis, Seeber, Mary, Urbach-Bolus, Dorothea, Bayat, Junaid, Boyd, Warren, du Toit, Margaretha, Punt, Zelda, Arnold, Susan, Van Dyk, Christo, Robertson, Leslie Ivan, Kotze, Hester Johanna, Anders, Luts, Martin, Lundvall, Carl-Johan, Lindholm, Bengt-Olov, Tengmark, Dan, Curiac, Peter, Bosson, Pekka, Koskinen, Hajimirsadeghi, Ali, Huang, Chen-Ling, Jiang, Ju-Ying, Hsia, Te- Lin, Ueng, Kwo-Chang, Yang, Wei-Shiung, Lu, Yung-Chuan, Yang, Chwen-Yi, Sheu, Wayne Huey-Herng, Chiang, Chern-En, Yeh, Hung-I, Suwanwalaikorn, Sompongse, Kosachunhanun, Natapong, Sritippayawan, Suchai, Tejavanija, Sirakarn, Silaruks, Songkwan, Araz, Mustafa, Sari, Ramazan, Berker, Dilek Sensoz, Arslan, Muyesser Sayki, Godlevska, Olga, Chopey, Ivan, Teliatnikova, Zinaida, Kuskalo, Petro, Abrahamovych, Orest, Mankovskyi, Borys, Fushtey, Ivan, Myshanych, Galyna, Tykhonova, Susanna, Tseluyko, Vira, Koval, Olena, Parkhomenko, Oleksandr, Prokhorov, Oleksandr, Vayda, Myroslava, Martymianova, Larysa, Zharinova, Viktoriia, Prystupa, Lyudmyla, Pererva, Larysa, Kovalov, Oleksandr, Sokolova, Lyubov, Botsyurko, Volodymyr, Maslyanko, Vitaliy, Vlasenko, Maryna, Khomazyuk, Tetyana, Kulyk, Anna, Synenko, Volodymyr, Karpenko, Oleksandr, Mostovoy, Yuriy, Gyrina, Olga, Dolzhenko, Maryna, Donets, Oleksandra, Sorokina, Inna, Malynovsky, Yaroslav, Lysunets, Olena, Petrovskyy, Roman, Panina, Svitlana, Avornyo, Anthony, Eyre, Susannah, Ryan, John, Cardwell, Glenn, Robinson, Anthony, Clark, Rebecca, Issa, Basil, Weeraratne, Devinda, McCrimmon, Rory, Jones, Thomas, Philip, Sam, Beboso, Ronnie, Davies, Melanie, Kyriakidou, Christina, Saxena, Manish, Thomas, Hawys, Gowda, Madhu, Arif, Imrozia, Oyesile, Babatunde, Cecil, John, Brunskill, Jonathan Mark Edwin, Akinboboye, Olakunle, Akright, Laura, Arora, Chander, Ball, Eric, Benjamin, Sabrina, Budoff, Matthew, Cathcart, Harold, Daboul, Nizar, Denker, Paul, Garner, Andrew, Jabbour, Serge, Jaffrani, Naseem, Jeanfreau, Robert, Knutson, Thomas, Lillestol, Michael, McNeil, Donald, Nakhle, Samer, Randall, William, Mallepalli, Jyothi, Schmidt, Jay, Serje, Jorge, Shoemaker, James, Storey, Daniel, Warner, Alberta, Pimentel, Severino, Quintero, Luis, Galvez, Juan, Bernard, David, Cruz, Humberto, O'Donnell, Philip, Thawani, Hemant, Sorial, Ehab, Schwartzbard, Arthur, Agaiby, John, Garcia, Bernard, Cone, Clancy, Doshi, Ankur, Iranmanesh, Ali, Lingvay, Ildiko, Smith, Kimberly, McLean, Barry, Neutel, Joel, Odugbesan, Adeniyi, Sligh, Teresa, Lesh, Kurt, Rohr, Kathryn, Ajani, Dilawar, Daniel, Jerome, Cornett, George, Dykstra, Gary, Mahal, Sharan, Adams, Michael, Ramstad, David, Arif, Ahmed, Martin, Earl, Sastre, Ramon, Srivastava, Sunny, Feld, Lawrence, Bush, Kelvin, Shah, Vinay, Konigsberg, Sarah, Allaw, Mohammed, Kelly, Richard, MacGillivray, Brian, McGuire, Michael, Weinstein, Debra, Budhraja, Madhusudan, Tahirkheli, Naeem, Binker, Josefa, Bernstein, Marc, Andrawis, Nabil, Abdullah, Shuaib, Christensen, Tom, Khan, Misal, El Shahawy, Mahfouz, Tripathy, Devjit, Ranadive, Nandkishore, Grena, Paul, Villafuerte, Betty, Cook, Charles, Bautista, Jose, Marar, Isam, Kaunzinger, Christian, Bittar, Neville, Frias, Juan, Davit, Rajesh, Bays, Harold, Cohen, Robert, Garvey, William, Smith, Stephen, Ruiz, Jose-Luis, Hartman, Aaron, Diener, James, Chochinov, Ronald, Hunter, John, Aronoff, Stephen, Reed, Larry, Evans, John, Ackermann, Jeremy, Haaksma, James, Torres-Consuegra, Aurelio, Khan, Jalil, Yousuf, Kabir, Bermudez, Lidia, Lumicao, Benjamin, Olmeda, Jorge Torres, Kessler, Evan, Winnie, Michael, Lending, Robert, Razzaque, Naveed, McCartney, Michael, Munoz, Francisco, Buynak, Robert, Ables, Lilia Rodriguez, Makam, Sashi, Lozano, Josefina, Paez, Henry, Gore, Ashwini, Al-Karadsheh, Amer, Masri, Bassem, Gorrela, Sushma, Al-Amin, Jessie Louise, Alani, Firas, Haffizulla, Jason, Hsieh, Ron, Hernandez, Luis Castillo, Turner, Merle, French, William, Jetty, Preetham, Sheikh-Ali, Mae, Leggett, Richard, Perlman, Richard, Goldstein, Gary, Osea, Edgardo A., Bartkowiak, Anthony James, Gimness, Michael Paul, Higgins, Alexander John, Khan, Sohail Mohyuddin, Rahimi, Ali R, Shah, Anil Vallabhdas, Lillo, Joseph Leonard, Hartman, Israel Alejandro, Whitney, Edwin J., Johnston, Janice G., Juarez, Mario R., Perley, Michael J., Kahn, Brian Howard, Amine, Maged A., Pace, Michael Anthony, Peters, Shirin Sabina, Hidalgo, Horacio Augusto, Krichmar, Perry, and Sinha, Rabi Ranjan
Published: 2021
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15. The Changing Landscape for Stroke Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Author: Huisman, M, Rothman, K, Paquette, M, Teutsch, C, Diener, H, Dubner, S, Halperin, J, Ma, C, Zint, K, Elsaesser, A, Bartels, D, Lip, G, Abban, D, Abdul, N, Abelson, M, Ackermann, A, Adams, F, Adams, L, Adragão, P, Ageno, W, Aggarwal, R, Agosti, S, Marin, J, Aguilar, F, Aguilar Linares, J, Aguinaga, L, Ahmad, Z, Ainsworth, P, Al Ghalayini, K, Al Ismail, S, Alasfar, A, Alawwa, A, Al Dallow, R, Alderson, L, Alexopoulos, D, Ali, A, Ali, M, Aliyar, P, Al Joundi, T, Al Mahameed, S, Almassi, H, Almuti, K, Al Obaidi, M, Alshehri, M, Altmann, U, Alves, A, Al Zoebi, A, Amara, W, Amelot, M, Amjadi, N, Ammirati, F, Andrawis, N, Angoulvant, D, Annoni, G, Ansalone, G, Antonescu, S, Ariani, M, Arias, J, Armero, S, Arora, R, Arora, C, Ashcraft, W, Aslam, M, Astesiano, A, Audouin, P, Augenbraun, C, Aydin, S, Azar, R, Azim, A, Aziz, S, Backes, L, Baig, M, Bains, S, Bakbak, A, Baker, S, Bakhtiar, K, Bala, R, Banayan, J, Bandh, S, Bando, S, Banerjee, S, Bank, A, Barbarash, O, Barón, G, Barr, C, Barrera, C, Barton, J, Kes, V, Baula, G, Bayeh, H, Bazargani, N, Behrens, S, Bell, A, Benezet Mazuecos, J, Benhalima, B, Berdagué, P, Berg van den, B, Bergen van, P, Berngard, E, Bernstein, R, Berrospi, P, Berti, S, Bertomeu, V, Berz, A, Bettencourt, P, Betzu, R, Beyer Westendorf, J, Bhagwat, R, Black, T, Blanco Ibaceta, J, Bloom, S, Blumberg, E, Bo, M, Bockisch, V, Bøhmer, E, Bongiorni, M, Boriani, G, Bosch, R, Boswijk, D, Bott, J, Bottacchi, E, Kalan, M, Brandes, A, Bratland, B, Brautigam, D, Breton, N, Brouwers, P, Browne, K, Bruguera, J, Brunehaut, M, Brunschwig, C, Buathier, H, Buhl, A, Bullinga, J, Butcher, K, Cabrera Honorio, J, Caccavo, A, Cadinot, D, Cai, S, Calvi, V, Camm, J, Candeias, R, Capo, J, Capucci, A, Cardoso, J, Duarte Vera, Y, Carlson, B, Carvalho, P, Cary, S, Casanova, R, Casu, G, Cattan, S, Cavallini, C, Cayla, G, Cha, T, Cha, K, Chaaban, S, Chae, J, Challappa, K, Chand, S, Chandrashekar, H, Chang, M, Charbel, P, Chartier, L, Chatterjee, K, Cheema, A, Chen, S, Chevallereau, P, Chiang, F, Chiarella, F, Chih Chan, L, Cho, Y, Choi, D, Chouinard, G, Danny, N, Chow, H, Chrysos, D, Chumakova, G, José Roberto Chuquiure Valenzuela, E, Cieza Lara, T, Nica, V, Ciobotaru, V, Cislowski, D, Citerne, O, Claus, M, Clay, A, Clifford, P, Cohen, S, Cohen, A, Colivicchi, F, Collins, R, Compton, S, Connors, S, Conti, A, Buenostro, G, Coodley, G, Cooper, M, Corbett, L, Corey, O, Coronel, J, Corrigan, J, Cotrina Pereyra, R, Cottin, Y, Coutu, B, Cracan, A, Crean, P, Crenshaw, J, Crijns, H, Crump, C, Cucher, F, Cudmore, D, Cui, L, Culp, J, Darius, H, Dary, P, Dascotte, O, Dauber, I, Davee, T, Davies, R, Davis, G, Davy, J, Dayer, M, De La Briolle, A, de Mora, M, De Teresa, E, De Wolf, L, Decoulx, E, Deepak, S, Defaye, P, Del Carpio Munoz, F, Brkljacic, D, Deluche, L, Destrac, S, Deumite, N, Di Legge, S, Dibon, O, Diemberger, I, Dillinger, J, Dionísio, P, Naydenov, S, Dotani, I, Dotcheva, E, D'Souza, A, Dubrey, S, Ducrocq, X, Dupljakov, D, Duthinh, V, Dutra, O, Dutta, D, Duvilla, N, Dy, J, Dziewas, R, Eaton, C, Eaves, W, Ebinger, M, Eck van, J, Edwards, T, Egocheaga, I, Ehrlich, C, Eisenberg, S, El Hallak, A, El Jabali, A, El Mahmoud, R, El Shahawy, M, Eldadah, Z, Elghelbazouri, F, Elhag, O, El Hamdani, M, Elias, D, Ellery, A, El Sayed, H, Elvan, A, Erickson, B, Espaliat, E, Essandoh, L, Everington, T, Evonich, R, Ezhov, A, Fácila, L, Farsad, R, Fayard, M, Fedele, F, Gomes Ferreira, L, Ferreira, D, Santos, J, Ferrier, A, Finsen, A, First, B, Fisher, R, Floyd, J, Folk, T, Fonseca, C, Fonseca, L, Forman, S, Forsgren, M, Foster, M, Foster, N, Frais, M, Frandsen, B, Frappé, T, Freixa, R, French, W, Freydlin, M, Frickel, S, Fruntelata, A, Fujii, S, Fujino, Y, Fukunaga, H, Furukawa, Y, Gabelmann, M, Gabris, M, Gadsbøll, N, Galin, P, Galinier, M, Ganim, R, Garcia, R, Quintana, A, Gartenlaub, O, Genz, C, Georger, F, Georges, J, Georgeson, S, Ghanbasha, A, Giedrimas, E, Gierba, M, Gillespie, E, Giniger, A, Gkotsis, A, Gmehling, J, Gniot, J, Goethals, P, Goldberg, R, Goldmann, B, Goldscher, D, Golitsyn, S, Gomez Lopez, E, Gomez Mesa, J, Gonzalez, E, Cocina, E, Juanatey, C, Gorbunov, V, Gordon, B, Gorka, H, Gornick, C, Gorog, D, Goss, F, Götte, A, Goube, P, Goudevenos, I, Goulden, D, Graham, B, Grande, A, Greco, C, Green, M, Greer, G, Gremmler, U, Grena, P, Grinshstein, Y, Grond, M, Gronda, E, Grondin, F, Grönefeld, G, Groot de, J, Guardigli, G, Guarnieri, T, Caiedo, C, Guignier, A, Gulizia, M, Gumbley, M, Gupta, D, Hack, T, Haerer, W, Hakas, J, Hall, C, Hampsey, J, Hananis, G, Hanbali, B, Handel, F, Hargrove, J, Hargroves, D, Harris, K, Hartley, D, Haruna, T, Hata, Y, Hayek, E, Healey, J, Hearne, S, Heggelund, G, Hemels, M, Hemery, Y, Henein, S, Henz, B, Her, S, Hermany, P, Hernandes, M, Higashino, Y, Hill, M, Hisadome, T, Hishida, E, Hitchcock, J, Hoffer, E, Hoghton, M, Holmes, C, Hong, S, Houppe Nousse, M, Howard, V, Hsu, L, Huang, C, Huckins, D, Huehnergarth, K, Huizenga, A, Huntley, R, Hussein, G, Hwang, G, Igbokidi, 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Zeuthen, E, Zhang, X, Zhang, Q, Zhang, D, Zhang, H, Zhao, S, Zhao, X, Zheng, Y, Zheng, Q, Zhou, J, Zimmermann, S, Zimmermann, R, Zukerman, L, Zwaan van der, C, Zwaan van der, C., and ANNONI, GIORGIO
Abstract: Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non–vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients’ baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score ≥2; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients rece
Published: 2017

16. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial

Author: Bhatt, Deepak L, Steg, Philippe Gabriel, Mehta, Shamir R, Leiter, Lawrence A, Simon, Tabassome, Fox, Kim, Held, Claes, Andersson, Marielle, Himmelmann, Anders, Ridderstråle, Wilhelm, Chen, Jersey, Song, Yang, Diaz, Rafael, Goto, Shinya, James, Stefan K, Ray, Kausik K, Parkhomenko, Alexander N, Kosiborod, Mikhail N, McGuire, Darren K, Harrington, Robert A, Santos, Vladimir, Jain, Ashit, Lendel, Irina, Russo, Michael, Haught, W H, Bouza, Manuel, Gogia, Harinder, Banerjee, Supratim, Kichura, George, Kantaros, Louis, Padron, Francisco, Passi, Rakesh, Stone, Jay, Pursley, Michael, D'Urso, Michael, Gardner, Timothy, Bennett, James, Nour, Khaled, Saini, Satinder, Zhang, Wenwu, Kumbhani, Dharam, Thomas, Dustin, Angiolillo, Dominick, Bertolet, Barry, Roman-Miranda, Amaury, Black, Robert, Manshadi, Ramin, Vaca, Carlos, Blanco, Antonio, Napoli, Mark, Brabham, David, Akyea-Djamson, Ayim, Desai, Pratik, Prasada, Sudhir, Khaira, Ajit, Forgosh, Leslie, Lieber, Ira, Umpierrez, Guillermo, Singal, Dinesh, Londono, Juan, Fraser, Neil, Ruiz, Jose, Vega, Damaris, Rodriguez, Lilia, Brown, Christopher, Syed, Faizullah, Aggarwala, Guarav, Eaves, William, Foster, Michael, Gupta, Dinesh, Avino, David, Asfour, Wail, Tonnessen, Glen, Zhao, Xue-Qiao, Singh, Narendra, Brockmyre, Andrew, Lepor, Norman, Shammas, Nicolas, Blick, David, Hearne, Steven, Prodafikas, John, Carell, Edgar, Izzo, Mark, Karim, Amin, Zakhary, Bosh, Atieh, Mahmoud, Leichter, Steven, Meadows, Charles, Hotchkiss, David, Abu-Fadel, Mazen, Wiseman, Alan, Bander, Jeffrey, Shah, Mahesh, Banerjee, Subhash, Ganim, Ricky, Sopko, Karen, Khan, Misal, Lloret, Ramon, Weirick, Troy, Mehta, Rajendra, Thadani, Udho, Bhargava, Anuj, Kosiborod, Mikhail, Moya, Jaynier, Staniloae, Cezar, Guerra, Yamirka D, Chhabra, Anil, Kosmicki, Douglas, Shaheen, Wassim, Mohammed, Akber, Bitters, J'Cinda, Pattanayak, Jan, Javier, Julian, Srivastava, Sunny, Phillips, Roland, Al-Amin, Jessie, Lillestol, Michael, Simpson, Patrick, Hazan, Lydie, Amin, Amit, Shah, Gopi, Korpas, Denes, Platt, Bruce, Dickert, Jim, Puente, Orlando, Hiotis, Louis, Doyle, Timothy, Rajan, Raj, Meholick, Alan, Gring, Christian, Hage-Korban, Elie, Feldman, Robert, Colfer, Harry, Butman, Samuel, Foster, Malcolm, Hart, Terence, Huling, Randall, Eshaghian, Shervin, Quintana, Ofsman, Cheung, Deanna, Handel, Franklin, Rodriguez, Mara, Suh, David, Gordon, Paul, Pressman, Gregg, Bauer, Michael, French, William, Barettella, Mark, Chatrathi, Sridhar, Suresh, Damodhar, Goldberg, Ronald, Huth, Mark, Younis, Liwa, Rahman, Aref, Mascolo, Richard, Welch, Michelle, Suneja, Randeep, Smith, Stephen, Shurmur, Scott, Agaiby, John, Jingo, Ahmad, Johnston, Janice, Beth, Mary, Vlastaris, Anthony, Kemp, Susan, Taheri, Hamid, Pereira, Edward, Deyoung, Michael, Hawa, Zafir, Smith, Ray, Galski, Thomas, Garas, Samer, Reddy, M, Sharma, Susheel, Hargrove, Joeseph, Treasure, Charles, Emerson, Ronald, Haddad, Tariq, Rohr, Kathryn, Levinson, Larry, Gaona, Raul, Uretsky, Barry, Maheshwari, Hiralal, Lee, Denny, Kinnaman, Stephanie, Singal, Robert, Geohas, Jeffrey, Gigliotti, Osvaldo, Raisinghani, Ajit, Khurana, Charanjit, Hella, Brent, Kelberman, Michael, Voyce, Steven, Singh, Sanjay, Lo, Eric, Singh, Pradeep, Goodfellow, Ross, Fischer, Stuart, Lorraine, Richard, Turner, Traci, Shanes, Jeffrey, Busch, Robert, Broker, Robert, Zaniewski, Michelle, Pounds, Kevin, Debs-Perez, Giselle, Ong, Stephen, Frandsen, Brad, Fullington, Douglas, Jaffrani, Naseem, Khan, Ahtaram, Lee, Marcus, Pouzar, Joe, Revtyak, George, Gonzalez, Julian, Nakhle, Samer, Murillo, Abel, Young, Douglas, Makam, Sashi, Syed, Mushtaq, Woolf, Kevin, Grena, Paul, Alfata, Sarab, Mahal, Sharan, Hoffman, David, Kizhakekuttu, Tinoy, Deering, Joseph, Bhavsar, Janak, Mikesell, Scott, Wilson, William, Wilson, Vance, El, Salah, Spinale, Francis, Kannarkat, Vinod, Rao, Sunder, Hanson, Lenita, Bertsch, John, Gonzalez-Ortiz, Elena, Severino, Norma, Willis, John, Schock, Joel, Bakhtari, Ladan, Gazmuri, Raul, Ansari, Saadat, Hall, Jason, Mehta, Arvind, Shealy, Neal, Zarich, Stuart, Singh, Deovrat, Vora, Kishor, Andrawis, Nabil, Molter, Darron, Maron, David, Cardona, Jose, D'Agostino, Ronald, Arshad, Tamjeed, Samaan, Rodney, Jones, David, Presser, Dale, Heath, John, Green, Sandy, Bittar, George, Henry, Sheldon, Korn, David, Schmedtje, John, Nadar, Venkatesh, Graham, Bruce, Labroo, Ajay, Clavijo, Leonardo, Roseman, Hal, Ledesma, Gilbert, Rosen, Robert, Dor, Isaac, Kirby, William, Sutton, Jennefer, Eder, Frank, Iteld, Bruce, Gomez-Cortes, Jose, Buchbinder, Maurice, Kasper, Joseph, Terrelonge, Antonio, Torres, Gustavo, Jagielo, Ted, Alvarez, Jose, Handelsman, Yehuda, Guillen, Mario, Richwine, Randall, Lewy-Alterbaum, Lorena, Corder, Clinton, Arvind, Moogali, Bolshoun, David, Mikhail, Magdy, Minton, Stephen, Alvarado, Odilon, Abbott, J, Cauthen, Brett, Welter, Ryan, Mintz, Randy, Cox, John, Quick, Annette, Weiss, Melvin, Dy, Johnny, Zebrack, James, Gandelman, Glenn, Hegde, Vinayak, Silver, Marc, DeGregorio, Michele, Lawson, William, Paa, Christopher, Bortnick, Anna, Krolick, Merrill, Sotolongo, Rodolfo, Cheirif, Jorge, Kumar, Priya, Nadar, Venkatesh, Jetty, Preetham, Patel, Ambar, Kruk, Mariusz, Kobielusz-Gembala, Iwona, Rewerska, Barbara, Madrzejewski, Adam, Milewski, Krzysztof, Cygler, Jerzy, Petryka-Mazurkiewicz, Joanna, Jastrzebski, Waldemar, Korecki, Janusz, Fil, Wojciech, Prokopczuk, Janusz, Bochenek, Anna, Wujkowski, Marek, Witek, Robert, Konczakowski, Piotr, Miekus, Pawel, Szczasny, Marcin, Musial, Wlodzimierz, Cymerman, Krzysztof, Lampart, Jacek, Mikosinski, Jacek, Szynal, Slawomir, Fares, Issa, Opolski, Grzegorz, Mazur, Stanislaw, Wozakowska-Kaplon, Beata, Bijata-Bronisz, Renata, Wierucki, Lukasz, Losa, Beata, Drelich, Grzegorz, Konieczny, Marek, Starczewski, Pawel, Pawlowicz, Lidia, Jesionowski, Pawel, Jurowiecki, Jaroslaw, Gniot, Jacek, Czyzycki, Mariusz, Stania, Karol, Kucharczyk-Bauman, Izabela, Busz-Papiez, Benita, Karczmarczyk, Agnieszka, Sudnik, Wanda, Koszek, Alina, Kolodziej, Piotr, Skwarna, Bartosz, Jaramillo, Nicolás, Jankowski, Maciej, Czochra, Wojciech, Kinasz, Leszek, Miklaszewicz, Beata, Stasinska, Teresa, Pluta, Wladyslaw, Basiak, Marcin, Rusicka, Teresa, Niedbal-Yahfouf, Izabela, Popenda, Grazyna, Korzeniak, Romuald, Mirek, Agnieszka, Mariankowski, Rafal, Wojnowski, Lukasz, Korol, Marek, Baszak, Jacek, Podolec, Piotr, Piesiewicz, Wojciech, Zurakowski, Aleksander, Luengas, Carlos, Skura, Marek, Pilecki, Piotr, Majchrzak, Piotr, Krzyzagórska, Ewa, Drozd, Marcin, Kaczmarek, Barbara, Sliwinska, Teresa, Zelazowska, Katarzyna, Sztembis, Rafal, Landa, Katarzyna, Matyszczak-Toniak, Lidia, Strojek, Krzysztof, Piepiorka, Marek, Malinowski, Robert, Górska, Maria, Stolarczyk-Sowa, Edyta, Romanowski, Leszek, Zinka, Elzbieta, Reszka, Zygfryd, Skierkowska, Joanna, Uzunow, Anna, Laskowska-Derlaga, Ewa, Puntus, Ekaterina, Kosmacheva, Elena D, Koziolova, Natalia, Pavlov, Prokhor, Supryadkina, Tatiana, Didenko, Yury, Kopylov, Philipp, Kazakov, Andrei, Aksentiev, Sergei, Vishneva, Elena, Repin, Alexey, Smolenskaya, Olga, Mantserova, Olga, Khrustalev, Oleg, Privalova, Elena, Konstantinov, Vladimir, Boldueva, Svetlana, Ezhov, Andrey, Chernyavsky, Alexander, Kamalov, Gadel, Galyavich, Albert, Zubeeva, Galina, Nechaeva, Galina, Shustov, Sergey, Dzhaiani, Nino, Treshkur, Tatiana, Osokina, Nataliya, Panov, Alexey, Shutemova, Elena, Makukhin, Valeriy, Kropotina, Tatiana, Tsyba, Larisa, Karpov, Yuri, Sizova, J M, Ballyuzek, Marina, Tarasov, Nikolay, Demchenko, Elena, Barbarash, Olga, Moiseev, Valentin, Markov, Valentin, Kuznetsov, Vadim, Viktorova, Inna, Sergienko, Igor, Ermoshkina, Lyudmila, Khasanov, Niyaz, Khlevchuk, Tatiana, Baglikov, Andrey, Shalaev, Sergey, Zonova, Elena, Reznik, Elena, Haisheva, Larisa, Morugova, Tatyana, Lomakin, Nikita, Vishnevsky, Alexander, Shvarts, Yuri, Magnitskaya, Olga, Mikhailusova, Marina, Pavlysh, Elena, Libov, Igor, Zateyschikova, Anna, Kostenko, Victor, Edin, Anton, Khovaeva, Yaroslava, Zakharov, Konstantin, Stryuk, Raisa, Khirmanov, Vladimir, Kanorskiy, Sergey, Yakushin, Sergey, Barabashkina, Anna, Li, Hongwei, Zhao, Qiang, Zhang, Jian, Ma, Jianhua, He, Yong, Luo, Ming, Zhang, Aidong, Zhang, Ningru, Chai, Yingru, Ma, Genshan, Wang, Hao, Liu, Zhigang, He, Lanjie, Song, Zhifang, Dong, Xiaolin, Tao, Liang, Li, Zhanquan, Su, Xi, Kong, Xiangqing, Niu, Heping, Ge, Junbo, Luo, Zhurong, Huang, Wenjun, Peng, Daoquan, Yuan, Zuyi, Milanova, Maria, Tenev, Doncho, Gogov, Antoni, Karageorgiev, Dimitar, Kolchev, Todor, Rusev, Nikolay, Georgieva, Nikolina, Kondov, Rumen, Rusinov, Veselin, Petrov, Ivo, Stanchev, Georgi, Konteva, Mariana, Dincheva, Adriana, Yaneva, Zdravka, Vatova, Ralitsa, Ilieva, Katya, Runev, Nikolai, Kolomanov, Borislav, Petrov, Ivan, Iliev, Nikolay, Tisheva, Snezhanka, Chompalova, Boryana, Tokmakova, Maria, Raev, Dimitar, Byanov, Kolyo, Markov, Dimitar, Mihov, Lenko, Mihov, Atanas, Milcheva, Nora, Minchev, Milen, Mollov, Mihail, Borisov, Borislav, Tihchev, Tihomir, 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Anders, Leonsson-Zachrisson, Maria, and Ridderstråle, Wilhelm
Abstract: Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor.
Published: 2019
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17. Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial

Author: Connolly, Stuart J, Eikelboom, John W, Bosch, Jackie, Dagenais, Gilles, Dyal, Leanne, Lanas, Fernando, Metsarinne, Kaj, O'Donnell, Martin, Dans, Anthony L, Ha, Jong-Won, Parkhomenko, Alexandr N, Avezum, Alvaro A, Lonn, Eva, Lisheng, Liu, Torp-Pedersen, Christian, Widimsky, Petr, Maggioni, Aldo P, Felix, Camilo, Keltai, Katalin, Hori, Masatsugu, Yusoff, Khalid, Guzik, Tomasz J, Bhatt, Deepak L, Branch, Kelley R H, Cook Bruns, Nancy, Berkowitz, Scott D, Anand, Sonia S, Varigos, John D, Fox, Keith A A, Yusuf, Salim, SALA, JORGELINA, CARTASEGNA, LUIS, VICO, MARISA, HOMINAL, MIGUEL ANGEL, HASBANI, EDUARDO, CACCAVO, ALBERTO, ZAIDMAN, CESAR, VOGEL, DANIEL, HRABAR, ADRIAN, SCHYGIEL, PABLO OMAR, CUNEO, CARLOS, LUQUEZ, HUGO, MACKINNON, IGNACIO J., AHUAD GUERRERO, RODOLFO ANDRES, COSTABEL, JUAN PABLO, BARTOLACCI, INES PALMIRA, MONTANA, OSCAR, BARBIERI, MARIA, GOMEZ VILAMAJO, OSCAR, GARCIA DURAN, RUBEN OMAR, SCHIAVI, LILIA BEATRIZ, GARRIDO, MARCELO, INGARAMO, ADRIAN, BORDONAVA, ANSELMO PAULINO, PELAGAGGE, MARIA JOSE, NOVARETTO, LEONARDO, ALBISU DI GENNERO, JUAN PABLO, IBANEZ SAGGIA, LUZ MARIA, ALVAREZ, MOIRA, VITA, NESTOR ALEJANDRO, MACIN, STELLA MARIS, DRAN, RICARDO DARIO, CARDONA, MARCELO, GUZMAN, LUIS, SARJANOVICH, RODOLFO JUAN, CUADRADO, JESUS, NANI, SEBASTIAN, LITVAK BRUNO, MARCOS RAUL, CHACON, CAROLINA, MAFFEI, LAURA ELENA, GRINFELD, DIEGO, VENSENTINI, NATALIA, MAJUL, CLAUDIO RODOLFO, LUCIARDI, HECTOR LUCAS, GONZALEZ COLASO, PATRICIA DEL CARMEN, FERRE PACORA, FREDY ANTONI, VAN DEN HEUVEL, PAUL, VERHAMME, PETER, ECTOR, BAVO, DEBONNAIRE, PHILIPPE, VAN DE BORNE, PHILIPPE, LEROY, JEAN, SCHROE, HERMAN, VRANCKX, PASCAL, ELEGEERT, IVAN, HOFFER, ETIENNE, DUJARDIN, KARL, INDIO DO BRASIL, CLARISSE, PRECOMA, DALTON, ABRANTES, JOSE ANTONIO, MANENTI, EULER, REIS, GILMAR, SARAIVA, JOSE, MAIA, LILIA, HERNANDES, MAURO, ROSSI, PAULO, ROSSI DOS SANTOS, FABIO, ZIMMERMANN, SERGIO LUIZ, RECH, RAFAEL, ABIB JR, EDUARDO, LEAES, PAULO, BOTELHO, ROBERTO, DUTRA, OSCAR, SOUZA, WEIMAR, BRAILE, MARIA, IZUKAWA, NILO, NICOLAU, JOSE CARLOS, TANAJURA, LUIZ FERNANDO, SERRANO JUNIOR, CARLOS VICENTE, MINELLI, CESAR, NASI, LUIZ ANTONIO, OLIVEIRA, LIVIA, DE CARVALHO CANTARELLI, MARCELO JOSE, TYTUS, RICHARD, PANDEY, SHEKHAR, LONN, EVA, CHA, JAMES, VIZEL, SAUL, BABAPULLE, MOHAN, LAMY, ANDRE, SAUNDERS, KEVIN, BERLINGIERI, JOSEPH, KIAII, BOB, BHARGAVA, RAKESH, MEHTA, PRAVINSAGAR, HILL, LAURIE, FELL, DAVID, LAM, ANDY, AL-QOOFI, FAISAL, BROWN, CRAIG, PETRELLA, ROBERT, RICCI, JOSEPH A, GLANZ, ANTHONY, NOISEUX, NICOLAS, BAINEY, KEVIN, MERALI, FATIMA, HEFFERNAN, MICHAEL, DELLA SIEGA, ANTHONY, DAGENAIS, GILLES R, DAGENAIS, FRANCOIS, BRULOTTE, STEEVE, NGUYEN, MICHEL, HARTLEIB, MICHAEL, GUZMAN, RANDOLPH, BOURGEOIS, RONALD, RUPKA, DENNIS, KHAYKIN, YAARIV, GOSSELIN, GILBERT, HUYNH, THAO, PILON, CLAUDE, CAMPEAU, JEAN, PICHETTE, FRANCIS, DIAZ, ARIEL, JOHNSTON, JAMES, SHUKLE, PRAVIN, HIRSCH, GREGORY, RHEAULT, PAUL, CZARNECKI, WLODZIMIERZ, ROY, ANNIE, NAWAZ, SHAH, FREMES, STEPHEN, SHUKLA, DINKAR, JANO, GABRIEL, COBOS, JORGE LEONARDO, CORBALAN, RAMON, MEDINA, MARCELO, NAHUELPAN, LEONARDO, RAFFO, CARLOS, PEREZ, LUIS, POTTHOFF, SERGIO, STOCKINS, BENJAMIN, SEPULVEDA, PABLO, PINCETTI, CHRISTIAN, VEJAR, MARGARITA, TIAN, HONGYAN, WU, XUESI, KE, YUANNAN, JIA, KAIYING, YIN, PENGFEI, WANG, ZHAOHUI, YU, LITIAN, WU, SHULIN, WU, ZONGQUI, LIU, SHAO WEN, BAI, XIAO JUAN, ZHENG, YANG, YANG, PING, YANG, YUN MEI, ZHANG, JIWEI, GE, JUNBO, CHEN, XIAO PING, LI, JUNXIA, HU, TAO HONG, ZHANG, RUIYAN, ZHENG, ZHE, CHEN, XIN, TAO, LIANG, LI, JIANPING, HUANG, WEIJIAN, FU, GUOSHENG, LI, CHUNJIAN, DONG, YUGANG, WANG, CHUNSHENG, ZHOU, XINMIN, KONG, YE, SOTOMAYOR, ARISTIDES, ACCINI MENDOZA, JOSE LUIS, CASTILLO, HENRY, URINA, MIGUEL, AROCA, GUSTAVO, PEREZ, MARITZA, MOLINA DE SALAZAR, DORA INES, SANCHEZ VALLEJO, GREGORIO, FERNANDO, MANZUR J, GARCIA, HENRY, GARCIA, LUIS HERNANDO, ARCOS, EDGAR, GOMEZ, JUAN, CUERVO MILLAN, FRANCISCO, TRUJILLO DADA, FREDY ALBERTO, VESGA, BORIS, MORENO SILGADO, GUSTAVO ADOLFO, ZIDKOVA, EVA, LUBANDA, JEAN-CLAUDE, KALETOVA, MARKETA, KRYZA, RADIM, MARCINEK, GABRIEL, RICHTER, MAREK, SPINAR, JINDRICH, MATUSKA, JIRI, TESAK, MARTIN, MOTOVSKA, ZUZANA, BRANNY, MARIAN, MALY, JIRI, MALY, MARTIN, WIENDL, MARTIN, FOLTYNOVA CAISOVA, LENKA, SLABY, JOSEF, VOJTISEK, PETR, PIRK, JAN, SPINAROVA, LENKA, BENESOVA, MIROSLAVA, CANADYOVA, JULIA, HOMZA, MIROSLAV, FLORIAN, JINDRICH, POLASEK, ROSTISLAV, COUFAL, ZDENEK, SKALNIKOVA, VLADIMIRA, BRAT, RADIM, BRTKO, MIROSLAV, JANSKY, PETR, LINDNER, JAROSLAV, MARCIAN, PAVEL, STRAKA, ZBYNEK, TRETINA, MARTIN, DUARTE, YAN CARLOS, POW CHON LONG, FREDDY, SANCHEZ, MAYRA, LOPEZ, JOSE, PERUGACHI, CARMITA, MARMOL, RICARDO, TRUJILLO, FREDDY, TERAN, PABLO, TUOMILEHTO, JAAKKO, TUOMILEHTO, HENRI, TUOMINEN, MARJA-LEENA, TUOMILEHTO, HENRI, KANTOLA, ILKKA, STEG, GABRIEL, ABOYANS, VICTOR, LECLERCQ, FLORENCE, FERRARI, EMILE, BOCCARA, FRANCK, MESSAS, EMMANUEL, MISMETTI, PATRICK, SEVESTRE, MARIE ANTOINETTE, CAYLA, GUILLAUME, MOTREFF, PASCAL, STOERK, STEFAN, DUENGEN, HANS-DIRK, STELLBRINK, CHRISTOPH, GUEROCAK, OSMAN, KADEL, CHRISTOPH, BRAUN-DULLAEUS, RUEDIGER, JESERICH, MICHAEL, OPITZ, CHRISTIAN, VOEHRINGER, HANS-FRIEDRICH, APPEL, KARL-FRIEDRICH, WINKELMANN, BERNHARD, DORSEL, THOMAS, NIKOL, SIGRID, DARIUS, HARALD, RANFT, JURGEN, SCHELLONG, SEBASTIAN, JUNGMAIR, WOLFGANG, DAVIERWALA, PIROZE, VORPAHL, MARC, BAJNOK, LASZLO, LASZLO, ZOLTAN, NOORI, EBRAHIM, VERESS, GABOR, VERTES, ANDRAS, ZSARY, ANDRAS, KIS, ERNO, KORANYI, LASZLO, BAKAI, JUDIT, BODA, ZOLTAN, POOR, FERENC, JARAI, ZOLTAN, KEMENY, VENDEL, BARTON, JOHN, MCADAM, BRENDAN, MURPHY, ANDREW, CREAN, PETER, MAHON, NIALL, CURTIN, RONAN, MACNEILL, BRIAIN, DINNEEN, SEAN, HALABI, MAJDI, ZIMLICHMAN, REUVEN, ZELTSER, DAVID, TURGEMAN, YOAV, KLAINMAN, ELIEZER, LEWIS, BASIL, KATZ, AMOS, ATAR, SHAUL, ZIMLICHMAN, REUVEN, NIKOLSKY, EUGENIA, BOSI, STEFANO, NALDI, MONICA, FAGGIANO, POMPILIO, ROBBA, DEBORA, MOS, LUCIO, SINAGRA, GIANFRANCO, COSMI, FRANCO, OLTRONA VISCONTI, LUIGI, CARMINE, DE MATTEIS, DI PASQUALE, GIUSEPPE, DI BIASE, MATTEO, MANDORLA, SARA, BERNARDINANGELI, MARINO, PICCINNI, GIOVANNI CARLO, GULIZIA, MICHELE MASSIMO, GALVANI, MARCELLO, VENTURI, FLAVIO, MOROCUTTI, GIORGIO, BALDIN, MARIA GRAZIA, OLIVIERI, CARLO, PERNA, GIAN PIERO, CIRRINCIONE, VINCENZO, KANNO, TAKAYASU, DAIDA, HIROYUKI, OZAKI, YUKIO, MIYAMOTO, NAOMASA, HIGASHIUE, SHINICHI, DOMAE, HIROSHI, HOSOKAWA, SHINOBU, KOBAYASHI, HIROO, KURAMOCHI, TAKEHIKO, FUJII, KENSHI, MIZUTOMI, KAZUAKI, SAKU, KEIJIRO, KIMURA, KAZUO, HIGUCHI, YOSHIHARU, ABE, MITSUNORI, OKUDA, HARUHITO, NODA, TOSHIYUKI, MITA, TERUAKI, HIRAYAMA, ATSUSHI, ONAKA, HARUHIKO, INOKO, MORIAKI, HIROKAMI, MITSUGU, OKUBO, MUNENORI, AKATSUKA, YUTAKA, IMAMAKI, MIZUHO, KAMIYA, HARUO, MANITA, MAMORU, HIMI, TOSHIHARU, UENO, HIDEKI, HISAMATSU, YUJI, AKO, JUNYA, NISHINO, YASUHIRO, KAWAKAMI, HIDEO, YAMADA, YUTAKA, KORETSUNE, YUKIHIRO, YAMADA, TAKAHISA, YOSHIDA, TETSURO, SHIMOMURA, HIDEKI, KINOSHITA, NORIYUKI, TAKAHASHI, AKIHIKO, YUSOFF, KHALID, WAN AHMAD, WAN AZMAN, ABU HASSAN, MUHAMMAD RADZI, KASIM, SAZZLI, ABDUL RAHIM, AIZAI AZAN, MOHD ZAMRIN, DIMON, MACHIDA, MASAHARU, HIGASHINO, YORIHIKO, UTSU, NORIAKI, NAKANO, AKIHIKO, NAKAMURA, SHIGERU, HASHIMOTO, TETSUO, ANDO, KENJI, SAKAMOTO, TOMOHIRO, PRINS, F.J., LOK, DIRK, MILHOUS, JOHANNES GERT-JAN, VIERGEVER, ERIC, WILLEMS, FRANK, SWART, HENK, ALINGS, MARCO, BREEDVELD, ROB, DE VRIES, KEES-JAN, VAN DER BORGH, ROGER, OEI, FANNY, ZOET-NUGTEREN, STIENEKE, KRAGTEN, HANS, HERRMAN, JEAN PAUL, VAN BERGEN, PAUL, GOSSELINK, MARCEL, HOEKSTRA, EDUARD, ZEGERS, ERWIN, RONNER, EELKO, DEN HARTOG, FRANK, BARTELS, GERARD, NIEROP, PETER, VAN DER ZWAAN, COEN, VAN ECK, JACOB, VAN GORSELEN, EDWIN, GROENEMEIJER, BJORN, HOOGSLAG, PIETER, DE GROOT, MARC ROBERT, LOYOLA, ALDRIN, SULIT, DENNIS JOSE, REY, NANNETTE, ABOLA, MARIA TERESA, MORALES, DANTE, PALOMARES, ELLEN, ABAT, MARC EVANS, ROGELIO, GREGORIO, CHUA, PHILIP, DEL PILAR, JOSE CARLO, ALCARAZ, JOHN DENNIS, EBO, GERALDINE, TIRADOR, LOUIE, CRUZ, JOSEFINA, ANONUEVO, JOHN, PITARGUE, ARTHUR, JANION, MARIANNA, GUZIK, TOMASZ, GAJOS, GRZEGORZ, ZABOWKA, MACIEJ, RYNKIEWICZ, ANDRZEJ, BRONCEL, MARLENA, SZUBA, ANDRZEJ, CZARNECKA, DANUTA, MAGA, PAWEL, STRAZHESKO, IRINA, VASYUK, YURY, SIZOVA, ZHANNA, POZDNYAKOV, YURY, BARBARASH, OLGA, VOEVODA, MIKHAIL, POPONINA, TATIANA, REPIN, ALEXEY, OSIPOVA, IRINA, EFREMUSHKINA, ANNA, NOVIKOVA, NINA, AVERKOV, OLEG, ZATEYSHCHIKOV, DMITRY, VERTKIN, ARKADIY, AUSHEVA, AZA, COMMERFORD, PATRICK, SEEDAT, SAADIYA, VAN ZYL, LOUIS, ENGELBRECHT, JAN, MAKOTOKO, ELLEN MAKONLI, PRETORIUS, CATHARINA ELIZABETH, MOHAMED, ZAID, HORAK, ADRIAN, MABIN, THOMAS, KLUG, ERIC, BAE, JANG-HO, KIM, CHEOLHO, KIM, CHONG-JIN, KIM, DONG-SOO, KIM, YONG JIN, JOO, SEUNGJAE, HA, JONG-WON, PARK, CHUL SOO, KIM, JANG YOUNG, KIM, YOUNG-KWON, JARNERT, CHRISTINA, MOOE, THOMAS, DELLBORG, MIKAEL, TORSTENSSON, INGEMAR, ALBERTSSON, PER, JOHANSSON, LARS, AL-KHALILI, FARIS, ALMROTH, HENRIK, ANDERSSON, TOMMY, PANTEV, EMIL, TENGMARK, BENGT-OLOV, LIU, BO, RASMANIS, GUNDARS, WAHLGREN, CARL-MAGNUS, MOCCETTI, TIZIANO, PARKHOMENKO, ALEXANDER, TSELUYKO, VIRA, VOLKOV, VOLODYMYR, KOVAL, OLENA, KONONENKO, LYUDMYLA, PROKHOROV, OLEKSANDR, VDOVYCHENKO, VALERIY, BAZYLEVYCH, ANDRIY, RUDENKO, LEONID, VIZIR, VADYM, KARPENKO, OLEKSANDR, MALYNOVSKY, YAROSLAV, KOVAL, VALENTYNA, STOROZHUK, BORYS, COTTON, JAMES, VENKATARAMAN, ASOK, MORIARTY, ANDREW, CONNOLLY, DEREK, DAVEY, PATRICK, SENIOR, ROXY, BIRDI, INDERPAUL, CALVERT, JOHN, DONNELLY, PATRICK, TREVELYAN, JASPER, CARTER, JUSTIN, PEACE, AARON, AUSTIN, DAVID, KUKREJA, NEVILLE, HILTON, THOMAS, SRIVASTAVA, SUNNY, WALSH, RONALD, FIELDS, RONALD, HAKAS, JOSEPH, PORTNAY, EDWARD, GOGIA, HARINDER, SALACATA, ABRAHAM, HUNTER, JOHN J., BACHARACH, J MICHAEL, SHAMMAS, NICOLAS, SURESH, DAMODHAR, SCHNEIDER, RICKY, GURBEL, PAUL, BANERJEE, SUBHASH, GRENA, PAUL, BEDWELL, NOEL, SLOAN, STEPHEN, LUPOVITCH, STEVEN, SONI, ANAND, GIBSON, KATHLEEN, SANGRIGOLI, RENEE, MEHTA, RAJENDRA, I-HSUAN TSAI, PETER, GILLESPIE, EVE, DEMPSEY, STEPHEN, HAMROFF, GLENN, BLACK, ROBERT, LADER, ELLIS, KOSTIS, JOHN B., BITTNER, VERA, MCGUINN, WILLIAM, BRANCH, KELLEY, MALHOTRA, VINAY, MICHAELSON, STEPHEN, VACANTE, MICHAEL, MCCORMICK, MATTHEW, ARIMIE, RALUCA, CAMP, ALAN, DAGHER, GEORGE, KOSHY, N. MATHEW, THEW, STEPHEN, COSTELLO, FREDERICK, HEIMAN, MARK, CHILTON, ROBERT, MORAN, MICHAEL, ADLER, FREDRIC, COMEROTA, ANTHONY, SEIWERT, ANDREW, FRENCH, WILLIAM, SEROTA, HARVEY, HARRISON, ROBERT, BAKAEEN, FAISAL, OMER, SHUAB, CHANDRA, LOKESH, WHELAN, ALAN, BOYLE, ANDREW, ROBERTS-THOMSON, PHILIP, ROGERS, JAMES, CARROLL, PATRICK, COLQUHOUN, DAVID, SHAW, JAMES, BLOMBERY, PETER, AMERENA, JOHN, HII, CHRIS, ROYSE, ALISTAIR, SINGH, BHUWAN, SELVANAYAGAM, JOSEPH, JANSEN, SHIRLEY, LO, WINGCHI, HAMMETT, CHRISTOPHER, POULTER, ROHAN, NARASIMHAN, SESHASAYEE, WIGGERS, HENRIK, NIELSEN, HENRIK, GISLASON, GUNNAR, KOBER, LARS, HOULIND, KIM, BOENELYKKE SOERENSEN, VIBEKE, DIXEN, ULRIK, REFSGAARD, JENS, ZEUTHEN, ELISABETH, SOEGAARD, PETER, HRANAI, MARIAN, GASPAR, LUDOVIT, PELLA, DANIEL, HATALOVA, KATARINA, DROZDAKOVA, ERIKA, COMAN, IOAN, DIMULESCU, DOINA, VINEREANU, DRAGOS, CINTEZA, MIRCEA, SINESCU, CRINA, ARSENESCU, CATALINA, BENEDEK, IMRE, BOBESCU, ELENA, DOBREANU, DAN, GAITA, DAN, IANCU, ADRIAN, ILIESIU, ADRIANA, LIGHEZAN, DANIEL, PETRESCU, LUCIAN, PIRVU, OCTAVIAN, TEODORESCU, IULIA, TESLOIANU, DAN, VINTILA, MARIUS MARCIAN, and CHIONCEL, OVIDIU
Abstract: Coronary artery disease is a major cause of morbidity and mortality worldwide, and is a consequence of acute thrombotic events involving activation of platelets and coagulation proteins. Factor Xa inhibitors and aspirin each reduce thrombotic events but have not yet been tested in combination or against each other in patients with stable coronary artery disease.
Published: 2018
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18. Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial

Author: Anand, Sonia S, Bosch, Jackie, Eikelboom, John W, Connolly, Stuart J, Diaz, Rafael, Widimsky, Peter, Aboyans, Victor, Alings, Marco, Kakkar, Ajay K, Keltai, Katalin, Maggioni, Aldo P, Lewis, Basil S, Störk, Stefan, Zhu, Jun, Lopez-Jaramillo, Patricio, O'Donnell, Martin, Commerford, Patrick J, Vinereanu, Dragos, Pogosova, Nana, Ryden, Lars, Fox, Keith A A, Bhatt, Deepak L, Misselwitz, Frank, Varigos, John D, Vanassche, Thomas, Avezum, Alvaro A, Chen, Edmond, Branch, Kelley, Leong, Darryl P, Bangdiwala, Shrikant I, Hart, Robert G, Yusuf, Salim, SALA, JORGELINA, CARTASEGNA, LUIS, VICO, MARISA, HOMINAL, MIGUEL ANGEL, HASBANI, EDUARDO, CACCAVO, ALBERTO, ZAIDMAN, CESAR, VOGEL, DANIEL, HRABAR, ADRIAN, SCHYGIEL, PABLO OMAR, CUNEO, CARLOS, LUQUEZ, HUGO, MACKINNON, IGNACIO J., AHUAD GUERRERO, RODOLFO ANDRES, COSTABEL, JUAN PABLO, BARTOLACCI, INES PALMIRA, MONTANA, OSCAR, BARBIERI, MARIA, GOMEZ VILAMAJO, OSCAR, GARCIA DURAN, RUBEN OMAR, SCHIAVI, LILIA BEATRIZ, GARRIDO, MARCELO, INGARAMO, ADRIAN, BORDONAVA, ANSELMO PAULINO, PELAGAGGE, MARIA JOSE, NOVARETTO, LEONARDO, ALBISU DI GENNERO, JUAN PABLO, IBANEZ SAGGIA, LUZ MARIA, ALVAREZ, MOIRA, VITA, NESTOR ALEJANDRO, MACIN, STELLA MARIS, DRAN, RICARDO DARIO, CARDONA, MARCELO, GUZMAN, LUIS, SARJANOVICH, RODOLFO JUAN, CUADRADO, JESUS, NANI, SEBASTIAN, LITVAK BRUNO, MARCOS RAUL, CHACON, CAROLINA, MAFFEI, LAURA ELENA, GRINFELD, DIEGO, VENSENTINI, NATALIA, MAJUL, CLAUDIO RODOLFO, LUCIARDI, HECTOR LUCAS, GONZALEZ COLASO, PATRICIA DEL CARMEN, FERRE PACORA, FREDY ANTONI, VAN DEN HEUVEL, PAUL, VERHAMME, PETER, ECTOR, BAVO, DEBONNAIRE, PHILIPPE, VAN DE BORNE, PHILIPPE, LEROY, JEAN, SCHROE, HERMAN, VRANCKX, PASCAL, ELEGEERT, IVAN, HOFFER, ETIENNE, DUJARDIN, KARL, INDIO DO BRASIL, CLARISSE, PRECOMA, DALTON, ABRANTES, JOSE ANTONIO, MANENTI, EULER, REIS, GILMAR, SARAIVA, JOSE, MAIA, LILIA, HERNANDES, MAURO, ROSSI, PAULO, ROSSI DOS SANTOS, FABIO, ZIMMERMANN, SERGIO LUIZ, RECH, RAFAEL, ABIB JR, EDUARDO, LEAES, PAULO, BOTELHO, ROBERTO, DUTRA, OSCAR, SOUZA, WEIMAR, BRAILE, MARIA, IZUKAWA, NILO, NICOLAU, JOSE CARLOS, TANAJURA, LUIZ FERNANDO, SERRANO JUNIOR, CARLOS VICENTE, MINELLI, CESAR, NASI, LUIZ ANTONIO, OLIVEIRA, LIVIA, DE CARVALHO CANTARELLI, MARCELO JOSE, TYTUS, RICHARD, PANDEY, SHEKHAR, LONN, EVA, CHA, JAMES, VIZEL, SAUL, BABAPULLE, MOHAN, LAMY, ANDRE, SAUNDERS, KEVIN, BERLINGIERI, JOSEPH, KIAII, BOB, BHARGAVA, RAKESH, MEHTA, PRAVINSAGAR, HILL, LAURIE, FELL, DAVID, LAM, ANDY, AL-QOOFI, FAISAL, BROWN, CRAIG, PETRELLA, ROBERT, RICCI, JOSEPH A, GLANZ, ANTHONY, NOISEUX, NICOLAS, BAINEY, KEVIN, MERALI, FATIMA, HEFFERNAN, MICHAEL, DELLA SIEGA, ANTHONY, DAGENAIS, GILLES R, DAGENAIS, FRANCOIS, BRULOTTE, STEEVE, NGUYEN, MICHEL, HARTLEIB, MICHAEL, GUZMAN, RANDOLPH, BOURGEOIS, RONALD, RUPKA, DENNIS, KHAYKIN, YAARIV, GOSSELIN, GILBERT, HUYNH, THAO, PILON, CLAUDE, CAMPEAU, JEAN, PICHETTE, FRANCIS, DIAZ, ARIEL, JOHNSTON, JAMES, SHUKLE, PRAVIN, HIRSCH, GREGORY, RHEAULT, PAUL, CZARNECKI, WLODZIMIERZ, ROY, ANNIE, NAWAZ, SHAH, FREMES, STEPHEN, SHUKLA, DINKAR, JANO, GABRIEL, COBOS, JORGE LEONARDO, CORBALAN, RAMON, MEDINA, MARCELO, NAHUELPAN, LEONARDO, RAFFO, CARLOS, PEREZ, LUIS, POTTHOFF, SERGIO, STOCKINS, BENJAMIN, SEPULVEDA, PABLO, PINCETTI, CHRISTIAN, VEJAR, MARGARITA, TIAN, HONGYAN, WU, XUESI, KE, YUANNAN, JIA, KAIYING, YIN, PENGFEI, WANG, ZHAOHUI, YU, LITIAN, WU, SHULIN, WU, ZONGQUI, LIU, SHAO WEN, BAI, XIAO JUAN, ZHENG, YANG, YANG, PING, YANG, YUN MEI, ZHANG, JIWEI, GE, JUNBO, CHEN, XIAO PING, LI, JUNXIA, HU, TAO HONG, ZHANG, RUIYAN, ZHENG, ZHE, CHEN, XIN, TAO, LIANG, LI, JIANPING, HUANG, WEIJIAN, FU, GUOSHENG, LI, CHUNJIAN, DONG, YUGANG, WANG, CHUNSHENG, ZHOU, XINMIN, KONG, YE, SOTOMAYOR, ARISTIDES, ACCINI MENDOZA, JOSE LUIS, CASTILLO, HENRY, URINA, MIGUEL, AROCA, GUSTAVO, PEREZ, MARITZA, MOLINA DE SALAZAR, DORA INES, SANCHEZ VALLEJO, GREGORIO, FERNANDO, MANZUR J, GARCIA, HENRY, GARCIA, LUIS HERNANDO, ARCOS, EDGAR, GOMEZ, JUAN, CUERVO MILLAN, FRANCISCO, TRUJILLO DADA, FREDY ALBERTO, VESGA, BORIS, MORENO SILGADO, GUSTAVO ADOLFO, ZIDKOVA, EVA, LUBANDA, JEAN-CLAUDE, KALETOVA, MARKETA, KRYZA, RADIM, MARCINEK, GABRIEL, RICHTER, MAREK, SPINAR, JINDRICH, MATUSKA, JIRI, TESAK, MARTIN, MOTOVSKA, ZUZANA, BRANNY, MARIAN, MALY, JIRI, MALY, MARTIN, WIENDL, MARTIN, FOLTYNOVA CAISOVA, LENKA, SLABY, JOSEF, VOJTISEK, PETR, PIRK, JAN, SPINAROVA, LENKA, BENESOVA, MIROSLAVA, CANADYOVA, JULIA, HOMZA, MIROSLAV, FLORIAN, JINDRICH, POLASEK, ROSTISLAV, COUFAL, ZDENEK, SKALNIKOVA, VLADIMIRA, BRAT, RADIM, BRTKO, MIROSLAV, JANSKY, PETR, LINDNER, JAROSLAV, MARCIAN, PAVEL, STRAKA, ZBYNEK, TRETINA, MARTIN, DUARTE, YAN CARLOS, POW CHON LONG, FREDDY, SANCHEZ, MAYRA, LOPEZ, JOSE, PERUGACHI, CARMITA, MARMOL, RICARDO, TRUJILLO, FREDDY, TERAN, PABLO, TUOMILEHTO, JAAKKO, TUOMILEHTO, HENRI, TUOMINEN, MARJA-LEENA, TUOMILEHTO, HENRI, KANTOLA, ILKKA, STEG, GABRIEL, ABOYANS, VICTOR, LECLERCQ, FLORENCE, FERRARI, EMILE, BOCCARA, FRANCK, MESSAS, EMMANUEL, MISMETTI, PATRICK, SEVESTRE, MARIE ANTOINETTE, CAYLA, GUILLAUME, MOTREFF, PASCAL, STOERK, STEFAN, DUENGEN, HANS-DIRK, STELLBRINK, CHRISTOPH, GUEROCAK, OSMAN, KADEL, CHRISTOPH, BRAUN-DULLAEUS, RUEDIGER, JESERICH, MICHAEL, OPITZ, CHRISTIAN, VOEHRINGER, HANS-FRIEDRICH, APPEL, KARL-FRIEDRICH, WINKELMANN, BERNHARD, DORSEL, THOMAS, NIKOL, SIGRID, DARIUS, HARALD, RANFT, JURGEN, SCHELLONG, SEBASTIAN, JUNGMAIR, WOLFGANG, DAVIERWALA, PIROZE, VORPAHL, MARC, BAJNOK, LASZLO, LASZLO, ZOLTAN, NOORI, EBRAHIM, VERESS, GABOR, VERTES, ANDRAS, ZSARY, ANDRAS, KIS, ERNO, KORANYI, LASZLO, BAKAI, JUDIT, BODA, ZOLTAN, POOR, FERENC, JARAI, ZOLTAN, KEMENY, VENDEL, BARTON, JOHN, MCADAM, BRENDAN, MURPHY, ANDREW, CREAN, PETER, MAHON, NIALL, CURTIN, RONAN, MACNEILL, BRIAIN, DINNEEN, SEAN, HALABI, MAJDI, ZIMLICHMAN, REUVEN, ZELTSER, DAVID, TURGEMAN, YOAV, KLAINMAN, ELIEZER, LEWIS, BASIL, KATZ, AMOS, ATAR, SHAUL, ZIMLICHMAN, REUVEN, NIKOLSKY, EUGENIA, BOSI, STEFANO, NALDI, MONICA, FAGGIANO, POMPILIO, ROBBA, DEBORA, MOS, LUCIO, SINAGRA, GIANFRANCO, COSMI, FRANCO, OLTRONA VISCONTI, LUIGI, CARMINE, DE MATTEIS, DI PASQUALE, GIUSEPPE, DI BIASE, MATTEO, MANDORLA, SARA, BERNARDINANGELI, MARINO, PICCINNI, GIOVANNI CARLO, GULIZIA, MICHELE MASSIMO, GALVANI, MARCELLO, VENTURI, FLAVIO, MOROCUTTI, GIORGIO, BALDIN, MARIA GRAZIA, OLIVIERI, CARLO, PERNA, GIAN PIERO, CIRRINCIONE, VINCENZO, KANNO, TAKAYASU, DAIDA, HIROYUKI, OZAKI, YUKIO, MIYAMOTO, NAOMASA, HIGASHIUE, SHINICHI, DOMAE, HIROSHI, HOSOKAWA, SHINOBU, KOBAYASHI, HIROO, KURAMOCHI, TAKEHIKO, FUJII, KENSHI, MIZUTOMI, KAZUAKI, SAKU, KEIJIRO, KIMURA, KAZUO, HIGUCHI, YOSHIHARU, ABE, MITSUNORI, OKUDA, HARUHITO, NODA, TOSHIYUKI, MITA, TERUAKI, HIRAYAMA, ATSUSHI, ONAKA, HARUHIKO, INOKO, MORIAKI, HIROKAMI, MITSUGU, OKUBO, MUNENORI, AKATSUKA, YUTAKA, IMAMAKI, MIZUHO, KAMIYA, HARUO, MANITA, MAMORU, HIMI, TOSHIHARU, UENO, HIDEKI, HISAMATSU, YUJI, AKO, JUNYA, NISHINO, YASUHIRO, KAWAKAMI, HIDEO, YAMADA, YUTAKA, KORETSUNE, YUKIHIRO, YAMADA, TAKAHISA, YOSHIDA, TETSURO, SHIMOMURA, HIDEKI, KINOSHITA, NORIYUKI, TAKAHASHI, AKIHIKO, YUSOFF, KHALID, WAN AHMAD, WAN AZMAN, ABU HASSAN, MUHAMMAD RADZI, KASIM, SAZZLI, ABDUL RAHIM, AIZAI AZAN, MOHD ZAMRIN, DIMON, MACHIDA, MASAHARU, HIGASHINO, YORIHIKO, UTSU, NORIAKI, NAKANO, AKIHIKO, NAKAMURA, SHIGERU, HASHIMOTO, TETSUO, ANDO, KENJI, SAKAMOTO, TOMOHIRO, PRINS, F.J., LOK, DIRK, MILHOUS, JOHANNES GERT-JAN, VIERGEVER, ERIC, WILLEMS, FRANK, SWART, HENK, ALINGS, MARCO, BREEDVELD, ROB, DE VRIES, KEES-JAN, VAN DER BORGH, ROGER, OEI, FANNY, ZOET-NUGTEREN, STIENEKE, KRAGTEN, HANS, HERRMAN, JEAN PAUL, VAN BERGEN, PAUL, GOSSELINK, MARCEL, HOEKSTRA, EDUARD, ZEGERS, ERWIN, RONNER, EELKO, DEN HARTOG, FRANK, BARTELS, GERARD, NIEROP, PETER, VAN DER ZWAAN, COEN, VAN ECK, JACOB, VAN GORSELEN, EDWIN, GROENEMEIJER, BJORN, HOOGSLAG, PIETER, DE GROOT, MARC ROBERT, LOYOLA, ALDRIN, SULIT, DENNIS JOSE, REY, NANNETTE, ABOLA, MARIA TERESA, MORALES, DANTE, PALOMARES, ELLEN, ABAT, MARC EVANS, ROGELIO, GREGORIO, CHUA, PHILIP, DEL PILAR, JOSE CARLO, ALCARAZ, JOHN DENNIS, EBO, GERALDINE, TIRADOR, LOUIE, CRUZ, JOSEFINA, ANONUEVO, JOHN, PITARGUE, ARTHUR, JANION, MARIANNA, GUZIK, TOMASZ, GAJOS, GRZEGORZ, ZABOWKA, MACIEJ, RYNKIEWICZ, ANDRZEJ, BRONCEL, MARLENA, SZUBA, ANDRZEJ, CZARNECKA, DANUTA, MAGA, PAWEL, STRAZHESKO, IRINA, VASYUK, YURY, SIZOVA, ZHANNA, POZDNYAKOV, YURY, BARBARASH, OLGA, VOEVODA, MIKHAIL, POPONINA, TATIANA, REPIN, ALEXEY, OSIPOVA, IRINA, EFREMUSHKINA, ANNA, NOVIKOVA, NINA, AVERKOV, OLEG, ZATEYSHCHIKOV, DMITRY, VERTKIN, ARKADIY, AUSHEVA, AZA, COMMERFORD, PATRICK, SEEDAT, SAADIYA, VAN ZYL, LOUIS, ENGELBRECHT, JAN, MAKOTOKO, ELLEN MAKONLI, PRETORIUS, CATHARINA ELIZABETH, MOHAMED, ZAID, HORAK, ADRIAN, MABIN, THOMAS, KLUG, ERIC, BAE, JANG-HO, KIM, CHEOLHO, KIM, CHONG-JIN, KIM, DONG-SOO, KIM, YONG JIN, JOO, SEUNGJAE, HA, JONG-WON, PARK, CHUL SOO, KIM, JANG YOUNG, KIM, YOUNG-KWON, JARNERT, CHRISTINA, MOOE, THOMAS, DELLBORG, MIKAEL, TORSTENSSON, INGEMAR, ALBERTSSON, PER, JOHANSSON, LARS, AL-KHALILI, FARIS, ALMROTH, HENRIK, ANDERSSON, TOMMY, PANTEV, EMIL, TENGMARK, BENGT-OLOV, LIU, BO, RASMANIS, GUNDARS, WAHLGREN, CARL-MAGNUS, MOCCETTI, TIZIANO, PARKHOMENKO, ALEXANDER, TSELUYKO, VIRA, VOLKOV, VOLODYMYR, KOVAL, OLENA, KONONENKO, LYUDMYLA, PROKHOROV, OLEKSANDR, VDOVYCHENKO, VALERIY, BAZYLEVYCH, ANDRIY, RUDENKO, LEONID, VIZIR, VADYM, KARPENKO, OLEKSANDR, MALYNOVSKY, YAROSLAV, KOVAL, VALENTYNA, STOROZHUK, BORYS, COTTON, JAMES, VENKATARAMAN, ASOK, MORIARTY, ANDREW, CONNOLLY, DEREK, DAVEY, PATRICK, SENIOR, ROXY, BIRDI, INDERPAUL, CALVERT, JOHN, DONNELLY, PATRICK, TREVELYAN, JASPER, CARTER, JUSTIN, PEACE, AARON, AUSTIN, DAVID, KUKREJA, NEVILLE, HILTON, THOMAS, SRIVASTAVA, SUNNY, WALSH, RONALD, FIELDS, RONALD, HAKAS, JOSEPH, PORTNAY, EDWARD, GOGIA, HARINDER, SALACATA, ABRAHAM, HUNTER, JOHN J., BACHARACH, J MICHAEL, SHAMMAS, NICOLAS, SURESH, DAMODHAR, SCHNEIDER, RICKY, GURBEL, PAUL, BANERJEE, SUBHASH, GRENA, PAUL, BEDWELL, NOEL, SLOAN, STEPHEN, LUPOVITCH, STEVEN, SONI, ANAND, GIBSON, KATHLEEN, SANGRIGOLI, RENEE, MEHTA, RAJENDRA, I-HSUAN TSAI, PETER, GILLESPIE, EVE, DEMPSEY, STEPHEN, HAMROFF, GLENN, BLACK, ROBERT, LADER, ELLIS, KOSTIS, JOHN B., BITTNER, VERA, MCGUINN, WILLIAM, BRANCH, KELLEY, MALHOTRA, VINAY, MICHAELSON, STEPHEN, VACANTE, MICHAEL, MCCORMICK, MATTHEW, ARIMIE, RALUCA, CAMP, ALAN, DAGHER, GEORGE, KOSHY, N. MATHEW, THEW, STEPHEN, COSTELLO, FREDERICK, HEIMAN, MARK, CHILTON, ROBERT, MORAN, MICHAEL, ADLER, FREDRIC, COMEROTA, ANTHONY, SEIWERT, ANDREW, FRENCH, WILLIAM, SEROTA, HARVEY, HARRISON, ROBERT, BAKAEEN, FAISAL, OMER, SHUAB, CHANDRA, LOKESH, WHELAN, ALAN, BOYLE, ANDREW, ROBERTS-THOMSON, PHILIP, ROGERS, JAMES, CARROLL, PATRICK, COLQUHOUN, DAVID, SHAW, JAMES, BLOMBERY, PETER, AMERENA, JOHN, HII, CHRIS, ROYSE, ALISTAIR, SINGH, BHUWAN, SELVANAYAGAM, JOSEPH, JANSEN, SHIRLEY, LO, WINGCHI, HAMMETT, CHRISTOPHER, POULTER, ROHAN, NARASIMHAN, SESHASAYEE, WIGGERS, HENRIK, NIELSEN, HENRIK, GISLASON, GUNNAR, KOBER, LARS, HOULIND, KIM, BOENELYKKE SOERENSEN, VIBEKE, DIXEN, ULRIK, REFSGAARD, JENS, ZEUTHEN, ELISABETH, SOEGAARD, PETER, HRANAI, MARIAN, GASPAR, LUDOVIT, PELLA, DANIEL, HATALOVA, KATARINA, DROZDAKOVA, ERIKA, COMAN, IOAN, DIMULESCU, DOINA, VINEREANU, DRAGOS, CINTEZA, MIRCEA, SINESCU, CRINA, ARSENESCU, CATALINA, BENEDEK, IMRE, BOBESCU, ELENA, DOBREANU, DAN, GAITA, DAN, IANCU, ADRIAN, ILIESIU, ADRIANA, LIGHEZAN, DANIEL, PETRESCU, LUCIAN, PIRVU, OCTAVIAN, TEODORESCU, IULIA, TESLOIANU, DAN, VINTILA, MARIUS MARCIAN, and CHIONCEL, OVIDIU
Abstract: Patients with peripheral artery disease have an increased risk of cardiovascular morbidity and mortality. Antiplatelet agents are widely used to reduce these complications.
Published: 2018
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19. Polymer Composite with Carbon Nanofibers Aligned during Thermal Drawing as a Microelectrode for Chronic Neural Interfaces

Author: Guo, Yuanyuan, Jiang, Shan, Grena, Benjamin J. B., Kimbrough, Ian F., Thompson, Emily G., Fink, Yoel, Sontheimer, Harald, Yoshinobu, Tatsuo, and Jia, Xiaoting
Abstract: Microelectrodes provide a direct pathway to investigate brain activities electrically from the external world, which has advanced our fundamental understanding of brain functions and has been utilized for rehabilitative applications as brain–machine interfaces. However, minimizing the tissue response and prolonging the functional durations of these devices remain challenging. Therefore, the development of next-generation microelectrodes as neural interfaces is actively progressing from traditional inorganic materials toward biocompatible and functional organic materials with a miniature footprint, good flexibility, and reasonable robustness. In this study, we developed a miniaturized all polymer-based neural probe with carbon nanofiber (CNF) composites as recording electrodes viathe scalable thermal drawing process. We demonstrated that in situCNF unidirectional alignment can be achieved during the thermal drawing, which contributes to a drastic improvement of electrical conductivity by 2 orders of magnitude compared to a conventional polymer electrode, while still maintaining the mechanical compliance with brain tissues. The resulting neural probe has a miniature footprint, including a recording site with a reduced size comparable to a single neuron and maintained impedance that was able to capture neural activities. Its stable functionality as a chronic implant has been demonstrated with the long-term reliable electrophysiological recording with single-spike resolution and the minimal tissue response over the extended period of implantation in wild-type mice. Technology developed here can be applied to basic chronic electrophysiological studies as well as clinical implementation for neuro-rehabilitative applications.
Published: 2017
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20. Stabilization Effect of Surface Impurities on the Structure of Ultrasmall ZrO2Nanoparticles: An Ab-Initio Study

Author: Grena, Roberto, Masson, Olivier, Portal, Laura, Rémondière, Fabien, Berghout, Abid, Jouin, Jenny, and Thomas, Philippe
Abstract: Real nanoparticles can hardly be considered as isolated objects in vacuum with pure stoichiometric chemical composition. It can be expected that some surface stabilizing mechanisms may occur in real systems, and they could induce more or less pronounced effects on the structure of nanoparticles. In this work, we analyzed the stabilizing effect of surface impurities on the structure of ultrasmall ZrO2nanoparticles using ab initio simulation methods. The study was performed on ZrO2cluster models, with a diameter around 1.25 nm, using the Car–Parrinello molecular dynamics method combined with standard structural optimization methods. After the study of the naked cluster, the stabilizing effect was investigated by adding chemisorbed water molecules at the particle surface, with a covering degree ranging from 15% to 100%. The results clearly indicated that energy minimizations leaded invariably to highly disordered structures in the case of naked nanoparticles. The structure of the models got more ordered only with increasing water coverage. The comparison, via the pair distribution functions (PDF), to the experimental data obtained from a sample of nanoparticles of comparable size showed a good agreement for a high (but not total) water coverage, indicating that a surface stabilizing effect is a sound hypothesis to explain the experimental results. Surface stabilizing effects play a crucial role in the case of ZrO2, in contrast with recent calculations performed on other chemical systems (CeO2or TiO2, for example); thus, for ZrO2a stabilizing mechanism, such as the one proposed in this paper, must be inevitably included in the model, and this fact markedly complicates the problem of solving the ZrO2nanocrystal structure.
Published: 2015
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21. Reining in a disruptive clinician

Author: Porto, Grena
Published: 2010
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22. Anticoagulant selection in relation to the SAMe-TT2R2score in patients with atrial fibrillation: The GLORIA-AF registry

Author: Ntaios, George, Huisman, Menno V., Diener, Hans-Christoph, Halperin, Jonathan L., Teutsch, Christine, Marler, Sabrina, Gurusamy, Venkatesh K., Thompson, Milla, Lip, Gregory Y.H., Olshansky, Brian, Abban, Dzifa Wosornu, Abdul, Nasser, Abud, Atilio Marcelo, Adams, Fran, Addala, Srinivas, Adragão, Pedro, Ageno, Walter, Aggarwal, Rajesh, Agosti, Sergio, Agostoni, Piergiuseppe, Aguilar, Francisco, Linares, Julio Aguilar, Aguinaga, Luis, Ahmed, Jameel, Aiello, Allessandro, Ainsworth, Paul, Aiub, Jorge Roberto, Al-Dallow, Raed, Alderson, Lisa, Aldrete Velasco, Jorge Antonio, Alexopoulos, Dimitrios, Manterola, Fernando Alfonso, Aliyar, Pareed, Alonso, David, Alves da Costa, Fernando Augusto, Amado, José, Amara, Walid, Amelot, Mathieu, Amjadi, Nima, Ammirati, Fabrizio, Andrade, Marianna, Andrawis, Nabil, Annoni, Giorgio, Ansalone, Gerardo, Ariani, M.Kevin, Arias, Juan Carlos, Armero, Sébastien, Arora, Chander, Aslam, Muhammad Shakil, Asselman, M., Audouin, Philippe, Augenbraun, Charles, Aydin, S., Ayryanova, Ivaneta, Aziz, Emad, Backes, Luciano Marcelo, Badings, E., Bagni, Ermentina, Baker, Seth H., Bala, Richard, Baldi, Antonio, Bando, Shigenobu, Banerjee, Subhash, Bank, Alan, Esquivias, Gonzalo Barón, Barr, Craig, Bartlett, Maria, Kes, Vanja Basic, Baula, Giovanni, Behrens, Steffen, Bell, Alan, Benedetti, Raffaella, Mazuecos, Juan Benezet, Benhalima, Bouziane, Bergler-Klein, Jutta, Berneau, Jean-Baptiste, Bernstein, Richard A., Berrospi, Percy, Berti, Sergio, Berz, Andrea, Best, Elizabeth, Bettencourt, Paulo, Betzu, Robert, Bhagwat, Ravi, Bhatta, Luna, Biscione, Francesco, BISIGNANI, Giovanni, Black, Toby, Bloch, Michael J., Bloom, Stephen, Blumberg, Edwin, Bo, Mario, Bøhmer, Ellen, Bollmann, Andreas, Bongiorni, Maria Grazia, Boriani, Giuseppe, Boswijk, D.J., Bott, Jochen, Bottacchi, Edo, Kalan, Marica Bracic, Bradman, Drew, Brautigam, Donald, Breton, Nicolas, Brouwers, P.J.A.M., Browne, Kevin, Cortada, Jordi Bruguera, Bruni, A., Brunschwig, Claude, Buathier, Hervé, Buhl, Aurélie, Bullinga, John, Cabrera, Jose Walter, Caccavo, Alberto, Cai, Shanglang, Caine, Sarah, Calò, Leonardo, Calvi, Valeria, Sánchez, Mauricio Camarillo, Candeias, Rui, Capuano, Vincenzo, Capucci, Alessandro, Caputo, Ronald, Rizo, Tatiana Cárdenas, Cardona, Francisco, Carlos da Costa Darrieux, Francisco, Duarte Vera, Yan Carlos, Carolei, Antonio, Carreño, Susana, Carvalho, Paula, Cary, Susanna, Casu, Gavino, Cavallini, Claudio, Cayla, Guillaume, Celentano, Aldo, Cha, Tae-Joon, Cha, Kwang Soo, Chae, Jei Keon, Chalamidas, Kathrine, Challappa, Krishnan, Chand, Sunil Prakash, Chandrashekar, Harinath, Chartier, Ludovic, Chatterjee, Kausik, Chavez Ayala, Carlos Antero, Cheema, Aamir, Cheema, Amjad, Chen, Lin, Chen, Shih-Ann, Chen, Jyh Hong, Chiang, Fu-Tien, Chiarella, Francesco, Chih-Chan, Lin, Cho, Yong Keun, Choi, Jong-Il, Choi, Dong Ju, Chouinard, Guy, Hoi-Fan Chow, Danny, Chrysos, Dimitrios, Chumakova, Galina, José Roberto Chuquiure Valenzuela, Eduardo Julián, Nica, Nicoleta Cindea, Cislowski, David J., Clay, Anthony, Clifford, Piers, Cohen, Andrew, Cohen, Michael, Cohen, Serge, Colivicchi, Furio, Collins, Ronan, Colonna, Paolo, Compton, Steve, Connolly, Derek, Conti, Alberto, Buenostro, Gabriel Contreras, Coodley, Gregg, Cooper, Martin, Coronel, Julian, Corso, Giovanni, Sales, Juan Cosín, Cottin, Yves, Covalesky, John, Cracan, Aurel, Crea, Filippo, Crean, Peter, Crenshaw, James, Cullen, Tina, Darius, Harald, Dary, Patrick, Dascotte, Olivier, Dauber, Ira, Davalos, Vicente, Davies, Ruth, Davis, Gershan, Davy, Jean-Marc, Dayer, Mark, De Biasio, Marzia, De Bonis, Silvana, De Caterina, Raffaele, De Franceschi, Teresiano, de Groot, J.R., De Horta, José, De La Briolle, Axel, Topete, Gilberto de la Pena, Vicenzo de Paola, Angelo Amato, de Souza, Weimar, de Veer, A., De Wolf, Luc, Decoulx, Eric, Deepak, Sasalu, Defaye, Pascal, Del-Carpio Munoz, Freddy, Brkljacic, Diana Delic, Deumite, N. Joseph, Di Legge, Silvia, Diemberger, Igor, Dietz, Denise, Dionísio, Pedro, Dong, Qiang, Rossi dos Santos, Fabio, Dotcheva, Elena, Doukky, Rami, D'Souza, Anthony, Dubrey, Simon, Ducrocq, Xavier, Dupljakov, Dmitry, Duque, Mauricio, Dutta, Dipankar, Duvilla, Nathalie, Duygun, A., Dziewas, Rainer, Eaton, Charles B., Eaves, William, Ebels-Tuinbeek, L.A., Ehrlich, Clifford, Eichinger-Hasenauer, Sabine, Eisenberg, Steven J., El Jabali, Adnan, El Shahawy, Mahfouz, Hernandes, Mauro Esteves, Izal, Ana Etxeberria, Evonich, Rudolph, Evseeva, Oksana, Ezhov, Andrey, Fahmy, Raed, Fang, Quan, Farsad, Ramin, Fauchier, Laurent, Favale, Stefano, Fayard, Maxime, Fedele, Jose Luis, Fedele, Francesco, Fedorishina, Olga, Fera, Steven R., Gomes Ferreira, Luis Gustavo, Ferreira, Jorge, Ferri, Claudio, Ferrier, Anna, Ferro, Hugo, Finsen, Alexandra, First, Brian, Fischer, Stuart, Fonseca, Catarina, Almeida, Luísa Fonseca, Forman, Steven, Frandsen, Brad, French, William, Friedman, Keith, Friese, Athena, Fruntelata, Ana Gabriela, Fujii, Shigeru, Fumagalli, Stefano, Fundamenski, Marta, Furukawa, Yutaka, Gabelmann, Matthias, Gabra, Nashwa, Gadsbøll, Niels, Galinier, Michel, Gammelgaard, Anders, Ganeshkumar, Priya, Gans, Christopher, Quintana, Antonio Garcia, Gartenlaub, Olivier, Gaspardone, Achille, Genz, Conrad, Georger, Frédéric, Georges, Jean-Louis, Georgeson, Steven, Giedrimas, Evaldas, Gierba, Mariusz, Ortega, Ignacio Gil, Gillespie, Eve, Giniger, Alberto, Giudici, Michael C., Gkotsis, Alexandros, Glotzer, Taya V., Gmehling, Joachim, Gniot, Jacek, Goethals, Peter, Goldbarg, Seth, Goldberg, Ronald, Goldmann, Britta, Golitsyn, Sergey, Gómez, Silvia, Mesa, Juan Gomez, Gonzalez, Vicente Bertomeu, Gonzalez Hermosillo, Jesus Antonio, González López, Víctor Manuel, Gorka, Hervé, Gornick, Charles, Gorog, Diana, Gottipaty, Venkat, Goube, Pascal, Goudevenos, Ioannis, Graham, Brett, Greer, G. Stephen, Gremmler, Uwe, Grena, Paul G., Grond, Martin, Gronda, Edoardo, Grönefeld, Gerian, Gu, Xiang, Torres Torres, Ivett Guadalupe, Guardigli, Gabriele, Guevara, Carolina, Guignier, Alexandre, Gulizia, Michele, Gumbley, Michael, Günther, Albrecht, Ha, Andrew, Hahalis, Georgios, Hakas, Joseph, Hall, Christian, Han, Bing, Han, Seongwook, Hargrove, Joe, Hargroves, David, Harris, Kenneth B., Haruna, Tetsuya, Hayek, Emil, Healey, Jeff, Hearne, Steven, Heffernan, Michael, Heggelund, Geir, Heijmeriks, J.A., Hemels, Maarten, Hendriks, I., Henein, Sam, Her, Sung-Ho, Hermany, Paul, Hernández Del Río, Jorge Eduardo, Higashino, Yorihiko, Hill, Michael, Hisadome, Tetsuo, Hishida, Eiji, Hoffer, Etienne, Hoghton, Matthew, Hong, Kui, Hong, Suk keun, Horbach, Stevie, Horiuchi, Masataka, Hou, Yinglong, Hsing, Jeff, Huang, Chi-Hung, Huckins, David, Hughes, kathy, Huizinga, A., Hulsman, E.L., Hung, Kuo-Chun, Hwang, Gyo-Seung, Ikpoh, Margaret, Imberti, Davide, Ince, Hüseyin, Indolfi, Ciro, Inoue, Shujiro, Irles, Didier, Iseki, Harukazu, Israel, C. Noah, Iteld, Bruce, Iyer, Venkat, Jackson-Voyzey, Ewart, Jaffrani, Naseem, Jäger, Frank, James, Martin, Jang, Sung-Won, Jaramillo, Nicolas, Jarmukli, Nabil, Jeanfreau, Robert J., Jenkins, Ronald D., Sánchez, Carlos Jerjes, Jimenez, Javier, Jobe, Robert, Joen-Jakobsen, Tomas, Jones, Nicholas, Moura Jorge, Jose Carlos, Jouve, Bernard, Jung, Byung Chun, Jung, Kyung Tae, Jung, Werner, Kachkovskiy, Mikhail, Kafkala, Krystallenia, Kalinina, Larisa, Kallmünzer, Bernd, Kamali, Farzan, Kamo, Takehiro, Kampus, Priit, Kashou, Hisham, Kastrup, Andreas, Katsivas, Apostolos, Kaufman, Elizabeth, Kawai, Kazuya, Kawajiri, Kenji, Kazmierski, John F., Keeling, P., Kerr Saraiva, José Francisco, Ketova, Galina, Khaira, AJIT Singh, Khripun, Aleksey, Kim, Doo-Il, Kim, Young Hoon, Kim, Nam Ho, Kim, Dae Kyeong, Kim, Jeong Su, Kim, June Soo, Kim, Ki Seok, Kim, Jin bae, Kinova, Elena, Klein, Alexander, Kmetzo, James J., Kneller, G. 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Abstract: The SAMe-TT2R2score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2scores >2 than to patients with lower scores.
Published: 2021
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23. Alogliptin after acute coronary syndrome in patients with type 2 diabetes

Author: White, W. B., Cannon, C. P., Heller, S. R., Nissen, S. E., Bergenstal, R. M., Bakris, G. L., Perez, A. T., Fleck, P. R., Mehta, C. R., Kupfer, S., Wilson, C., Cushman, W. C., Zannad, F., Aiub, J., Albisu, J., Alvarez, C., Astesiano, A., Barcudi, R., Bendersky, M., Bono, J., Bustos, B., Cartasegna, L., Caruso, O., Casabe, H., Castro, R., Colombo, H., Cuneo, C., Cura, F., Loredo, L., Dran, R., Fernandez, H., Garcia Pinna, J., Hrabar, A., Klyver Saleme, M., Luquez, H., Mackinnon, I., Maffei, L., Majul, C., Mallagray, M., Marino, J., Martinez, D., Martingano, R., Nul, D., Parody, M. L., Petrucci, J., Pieroni, M., Daniel Piskorz, Prado, A., Ramos, H., Resk, J., Rodriguez, M., Rojas, C., Sarjanovich, R., Sarries, A., Sessa, H., Silveiro, S., Sosa Liprandi, M. I., Tartaglione, J., Tonin, H., Vallejos, J., Vigo, S., Visco, V., Vita, N., Vogel, D., Vogelmann, O., Zaidman, C., Zangroniz, P., Colquhoun, D., Coverdale, S., Flecknoe-Brown, S., Hii, C. 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J., Mirasol, R., Morales-Palomares, E., Salvador, D. R., Sy, R. A., Tirador, L., Yao, C., Arciszewska, M., Bartkowiak, R., Czajkowska-Kaczmarek, E., Gil, R., Gniot, J., Janik, K., Janion, M., Jaworska, K., Jozwa, R., Kawecka-Jaszcz, K., Kawka-Urbanek, T., Kondys, M., Korecki, J., Korzeniak, R., Kowalisko, A., Krzeminska-Pakula, M., Kwiecien, J., Nessler, J., Odrowaz-Pieniazek, P., Piepiorka, M., Rajzer, M., Skokowska, E., Spyra, J., Sroka, M., Stasinska, T., Szymczyk, I., Trznadel-Morawska, I., Wysokinski, A., Mateus, P., Matos, P., Mimoso, J., Monteiro, P., Caballero, B., Garcia-Rinaldi, R., Gonzalez, E., Ortiz-Carrasquillo, R., Roman, A., Sierra, Y., Unger, N., Vazquez-Tanus, J., Alexandru, T., Busegeanu, M., Cozman, D. C., Fica, S., Minescu, B., Morosanu, M., Negrisanu, G. D., Pintilei, E., Pop, L., Szilagyi, I., Teodorescu, I., Tomescu, M., Barbarash, O., Chumakova, G., Churina, S., Dogadin, S., Dvoryashina, I., Esip, V., Glezer, M., Gordeev, I., Gordienko, A., Gratsiansky, N., Grineva, E., Khasanov, N., Kostenko, V., Meleshkevich, T., Mikhin, V., Morugova, T., Motylev, I., Nikolaev, K., Ponomareva, A., Repin, M., Reshetko, O., Shustov, S., Shutemova, E., Shvarts, Y., Simanenkov, V., Sobolev, K., Sukmanova, I., Timofeev, A., Tsyba, L., Varvarina, G., Vertkin, A., Vishnevsky, A., Volkov, D., Vorobiev, S., Vorokhobina, N., Yakhontov, D., Zonova, E., Zrazhevskiy, K., Damjanovic, S., Djordjevic, D., Pavlovic, M., Perunicic, J., Ristic, A., Stojkovic, S., Tasic, N., Bolvanska, N., Buganova, I., Dulkova, K., Dzupina, A., Fulop, P., Gergel, V., Kokles, M., Micko, K., Svoren, P., Urban, M., Vadinova, S., Vargova, A., Burgess, L., Coetzee, K., Du Toit, J., Gani, M., Joshi, P., Naiker, P., Nortje, H., Sarvan, M., Seeber, M., Siebert, M., Zyl, L., Wellmann, H., Calvo, C., La Hera, J., Teresa, L., Melero-Pita, A., Mesa, J., Parra Barona, J., Serrano, P., Soto, A., Tofe, S., Hornestam, B., Kempe, A., Rosenqvist, U., Rydberg, E., Tengmark, B. O., Torstensson, I., Chang, C. T., Hsia, T. L., Hsieh, I. C., Lai, W. T., Wu, C. J., Hutayanon, P., Kosachunhanun, N., Marapracertsak, M., Piamsomboon, C., Seekaew, S., Srimahachota, S., Sukhum, P., Suraamornkul, S., Tantiwong, P., Wongvipaporn, C., Amosova, K., Barna, O., Bazylevych, A., Berenfus, V., Dyadyk, A., Fushtey, I., Gyrina, O., Iabluchanskyi, M., Karpenko, O., Kaydashev, I., Korzh, O., Kulynych, R., Legkonogov, O., Mankovsky, B., Mostovoy, Y., Parkhomenko, O., Popik, G., Rudenko, L., Rudyk, I., Shevchuk, S., Sirenko, Y., Suprun, Y., Tryshchuk, N., Tseluyko, V., Vakaliuk, I., Al Mahmeed, W., Acheatel, R., Ahmad, A., Akbar, S., Akhter, F., Albirini, A., Alexander, A., Al-Joundi, B., Al-Joundi, T., Allen, G., Aloi, J., Alvarado, O., Alzohaili, O., Anderson, C., Arastu, A., Arena, C., Argoud, G., Ariani, M., Arora, C., Awasty, V., Barker, B., Barnum, O., Bartkowiak, A. J., Barzilay, J., Behrens, P., Belledonne, M., Bergman, B., Bilnoski, W., Bisognano, J., Bissette, S., Blumberg, E., Bonabi, N., Bradley, A., Breton, C., Britos, M., Broadstone, V., Budoff, M., Burge, M., Butman, S., Carroll, M., Challappa, K., Chepuri, V., Cherlin, R., Cheung, D., Coats, P., Collins, J., Cruz, H., Daboul, N., Damberg, G., David, W., Dean, J., Dedeke, E., Deeb, W., Dehaven, J., Dobs, A., Donelan, T., Dy, J., Dykstra, G., Eisen, H., Farris, N., Fattal, P., Fishman, N., Foster, M., Fredrickson, S., Gabra, N., Gabriel, J., Gatien, L., Giddings, S., Ginsberg, B., Gips, S., Glandt, M., Goldfein, A., Gordon, M., Gould, R., Graf, R., Graham, B., Graves, M., Grena, P., Hahn, R., Hamilton, D., Hamroff, G., Hanke, F., Haque, I., Harper, J., Harris, A., Harris, S., Henson, B., Hermanns, D., Herndon, W., Hershberger, V., Hyman, D., Isserman, S., Iteld, B., Jacob, M., Jaffrani, N., Jamal, A., Johnson, D., Johnson, G., Kaluski, E., Keller, R., Kereiakes, D., Khan, M., Khan, S., Klein, M., Knutson, T., Korban, E., Kozinn, M., Kraft, P., Kroeze, J., Kukuy, E., Lader, E., Laliotis, A., Lambert, C., Landau, C., Latif, K., Lee, K., Lester, F., Levenson, D., Levinson, D., Lewis, D., Litt, M., Littlefield, R., Lo, E., Lovell, C., Mahal, S., Makam, S., Mandviwala, M., Marar, I., Masri, B., Mattson, S., Mays, M., Mcgrew, F., Meengs, M., Mikell, F., Miller, M., Miranda, F., Moll, D., Multani, P., Munuswamy, K., Nallasivan, M., Nayles, L., Ong, S., Pacheco, T., Paez, H., Patel, S., Phillips, R., Pierpont, B., Prasad, J., Quinlan, E., Quion, J., Qureshi, M., Rahman, A., Raikhel, M., Ramanathan, K., Randhawa, P., Ravi, R., Reddy, R., Rendell, M., Rickner, K., Rictor, K., Rivas, J., Rosenblit, P., Rosenstock, J., Ross, S., Salacata, A., Saririan, M., Schima, S., Schlau, A., Schmedtje, J., Scott, C., Scott, D., Serru-Paez, A., Shah, R., Shah, A., Shaoulian, E., Shomali, M., Shubrook, J., Silver, K., Singh, S., Speer, J., Stevens, J., Stringam, S., Taussig, A., Taylor, A., Tee, H., Teixeira, G., Tilley, A., Toggart, E., Twahirwa, M., Unks, D., Vakili, B., Vora, K., Wang, X., Warner, A., Wefald, F., Weinberg, B., Weinstein, D., White, L., Wu, P., Yasuda, T., Yazdani, S., Yetman, C., Zarich, S., Zebrack, J., Fonseca, V. A., Mccullough, P. A., Desouza, C., Goff, D. C., Harrell, F. E., Menon, V., Sila, C., Kalahasti, V., Ahmed, S., Al Solaiman, F., Bennett, M., Cavender, M., Heil, B., Katzan, I., Monteleone, P., O Brien, B., Oommen, S., Senn, T., Sharma, J., Stegman, B., Uchino, K., Zishiri, E., Pasca, N., Brown, K., Scebbi, T., Atanasovski, I., Mccue, M., Streit, J., Oh, R., Bueno, O., Lee, D., Camisasca, R., Miyata, Y., Rubin, A., Williamson, N., Vara, S., Keeter, K., Ross, B., Los Reyes, A., Donnelly, J., Koshy-Hunt, S., Beers, B., Black, S., Buckley, M., Ephrem, M., Riley, B., West, N., Harre, M., Hsieh, R., Oshinyemi, K., Oka, Y., Matsui, N., Hoang, M., Doyle, C., Koziol, M., Lam, H., Edmonds, A., Azooz, W., Cao, C., Kim, D., Boeshaar, A., Dewindt, A., Nicholson, K., Smith, N., Hisada, M., Harding, S., Yoshioka, N., Gujral-Sandhu, K., Gans, J., Gresk, C., Kujawski, M. R., Villinski, A., Cosner, S., Johannsen, C., Barchha, N., and Knapp, B.

24. Multimaterial Porous Fibers.

Author: Grena, Benjamin, Jung-Tae Lee, Alayrac, Jean-Baptiste, Levy, Etgar, Stolyarov, Alexander M., Joannopoulous, John D., and Fink, Yoel
Published: 2017

25. Planning and Conservation: Green Areas and the Environmental Quality of the City of São Paulo

Author: Kliass, Rosa Grena
Published: 1990
Full Text: View/download PDF

26. Green Building Forecast Focuses on Renovation, Retrofits.

Author: Manley, Mary Ann Grena
Subjects: BUILDING repair, SUSTAINABLE buildings, FACILITY management, VALUATION
Abstract: The article reports on the huge market opportunities existing in the renovation and retrofitting of buildings, highlighted by the current green building practices. According to Malachite LLC founder and managing principal Leanne Tobias, green retrofits provide strong returns on investments and paybacks. It notes the findings released by CMP Industries LLC in August 2009, indicating that green buildings are more profitable, less risky and preferred by investors, and have the highest valuation.
Published: 2010

27. Green Market Trends Emphasize Accountability, Transparency.

Author: Manley, Mary Ann Grena
Subjects: COMMERCIAL markets, DUE diligence, RESPONSIBILITY -- Social aspects, SUSTAINABLE buildings
Abstract: The article discusses the results of the increase of environmental and financial due diligence of commercial real state markets in the U.S. According to the Dean of Environmental Bankers Association Jefferey Telego, carbon or climate risk plays a major influence on the market trend. It notes that many companies are now looking at sustainability, promoting financing on green buildings, and a new standard on green building disclosure.
Published: 2010

28. EPA Embracing Green Cleanups, Standard Forthcoming.

Author: Manley, Mary Ann Grena
Subjects: GREEN movement, ENVIRONMENTAL protection, CLIMATE change
Abstract: The article focuses on the green cleanups adopted by the Environmental Protection Agency (EPA) in the U.S. According to a coordinator for EPA, the agency is embracing the cleanups and it is looking at new initiatives to minimize its environmental footprint during the process, particularly on climate change concerns. It mentions that the cleanup activities use energy, water and natural resources and its concepts can be incorporated anywhere in the cleanup process.
Published: 2009

29. Forecast for Brownfields Redevelopment Remains Optimistic.

Author: Manley, Mary Ann Grena
Subjects: BROWNFIELDS, FINANCIAL bailouts
Abstract: The article reports on the status of brownfield redevelopment in the U.S. According to Charles Bartsch, vice president of ICF International, two congressional bailout packages that passed in 2008 provide opportunities for creative state, local and private brownfield reuse to promote brownfield revitalization efforts. Details of the provisions of the Housing and Economic Recovery Act are provided.
Published: 2008

30. Sustainability Nears Tipping Point for Companies, Law Firms.

Author: Manley, Mary Ann Grena
Subjects: CORPORATIONS, ASSOCIATIONS, institutions, etc., SUSTAINABLE development
Abstract: The article features corporations, associations and other private entities in the U.S. that are integrating sustainability into their business and operational practices. Under the leadership of former Environmental Protection Agency Deputy Administrator Linda J. Fisher, DuPont is committed to reducing its environmental footprint. Law firm Alston & Bird LLP formed its Energy Infrastructure, Climate and Technology (EICT) Group to respond to climate-related clients. The American Bar Association (ABA) plans to reduce greenhouse gas emissions.
Published: 2008

31. Green Buildings Helping the Environment, the Bottom Line.

Author: Manley, Mary Ann and Manley, Grena
Subjects: LEADERSHIP in Energy & Environmental Design, SUSTAINABLE building design & construction standards, TAX incentives, WATER efficiency, AIR quality, ENVIRONMENTAL quality
Abstract: The article discusses a voluntary program known as Leadership in Energy and Environmental Design (LEED) Green Building Rating System. LEED evaluates buildings in various different areas namely, energy and atmosphere, indoor environmental air quality, materials and resources, sustainable sites and water efficiency. LEED also has the capability to enhance the bottom line because certified projects may benefit from density bonuses, expedited permitting in some states and tax incentives.
Published: 2007

32. Claims for Injuries to Natural Resources Getting More Attention.

Author: Manley, Mary Ann Grena
Subjects: LIABILITY for environmental damages, ENVIRONMENTAL law, ENVIRONMENTAL degradation, ENVIRONMENTAL protection, ENVIRONMENTAL policy
Abstract: The article discusses the increased attention in claims for natural resource damages (NRD) under the Comprehensive Environmental Response, Compensation and Liability Act, the Clean Water Act and Oil Pollution Act. An overview of the basics of NRD is offered. The role of the Natural Resource Damage Assessment and Restoration Advisory Committee is discussed.
Published: 2006

33. Environmental Lawyers Sized Up for In-House Counsel Role.

Author: Manley, Mary Ann Grena
Subjects: ACCOUNTING standards, CORPORATIONS, DISCLOSURE in accounting, LAWYERS, BUSINESS enterprises & the environment
Abstract: Discusses compliance issues arising from the enactment of the accounting standard Sarbanes-Oxley Act of 2002 (SOX) in the U.S. Benefits of SOX to corporations; Impact of compliance and disclosure issues on in-house attorneys; Need for environmental issues to be incorporated into a business, according to David G. Mueller, senior managing attorney for CNH America LLC.
Published: 2006

34. Fundamental Shift in Environmental Disclosures on the Horizon.

Author: Manley, Mary Ann Grena
Subjects: ACCOUNTING standards, ENVIRONMENTAL policy, BUSINESS enterprises, RETIREMENT
Abstract: Discusses the implication of the Financial Interpretation Number 47 (FIN 47) and the 2002 Statement Number 143 (FAS 143) of the Financial Accounting Standards Board (FASB) for environmental disclosure and estimation of contingent environmental liabilities in the U.S. Requirement of FAS 143 for companies; Information on guidance offered by the FASB regarding the recognition of a retirement liability by companies under FIN 47; Effect of implementation of FAS 143/FIN 47 for certain environmental issues.
Published: 2005

35. Vapor Intrusion Issues Creeping Up at Contaminated Sites.

Author: Grena Manley, Mary Ann
Subjects: INDOOR air pollution, BUILDING materials & the environment, CONSTRUCTION on contaminated sites, HAZARDOUS waste sites, TRICHLOROETHYLENE & the environment
Abstract: Focuses on the issue of vapor intrusion in buildings that are becoming apparent at several contaminated sites and redeveloped properties that have employed risk-based cleanups in the U.S. Overview of the Environmental Protection Agency's (EPA) 2002 Draft Guidance for Evaluating Vapor Intrusion to Indoor Air Pathways from Groundwater and Soils; Potential risks posed by vapor intrusion; Information on several trichloroethylene testing performed by the EPA in several residential areas.
Published: 2004

36. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial

Author: Deepak L Bhatt, Philippe Gabriel Steg, Shamir R Mehta, Lawrence A Leiter, Tabassome Simon, Kim Fox, Claes Held, Marielle Andersson, Anders Himmelmann, Wilhelm Ridderstråle, Jersey Chen, Yang Song, Rafael Diaz, Shinya Goto, Stefan K James, Kausik K Ray, Alexander N Parkhomenko, Mikhail N Kosiborod, Darren K McGuire, Robert A Harrington, Vladimir Santos, Ashit Jain, Irina Lendel, Michael Russo, W H Haught, Manuel Bouza, Harinder Gogia, Supratim Banerjee, George Kichura, Louis Kantaros, Francisco Padron, Rakesh Passi, Jay Stone, Michael Pursley, Michael D'Urso, Timothy Gardner, James Bennett, Khaled Nour, Satinder Saini, Wenwu Zhang, Dharam Kumbhani, Dustin Thomas, Dominick Angiolillo, Barry Bertolet, Amaury Roman-Miranda, Robert Black, Ramin Manshadi, Carlos Vaca, Antonio Blanco, Mark Napoli, David Brabham, Ayim Akyea-Djamson, Pratik Desai, Sudhir Prasada, Ajit Khaira, Leslie Forgosh, Ira Lieber, Guillermo Umpierrez, Dinesh Singal, Juan Londono, Neil Fraser, Jose Ruiz, Damaris Vega, Lilia Rodriguez, Christopher Brown, Faizullah Syed, Guarav Aggarwala, William Eaves, Michael Foster, Dinesh Gupta, David Avino, Wail Asfour, Glen Tonnessen, Xue-Qiao Zhao, Narendra Singh, Andrew Brockmyre, Norman Lepor, Nicolas Shammas, David Blick, Steven Hearne, John Prodafikas, Edgar Carell, Mark Izzo, Amin Karim, Bosh Zakhary, Mahmoud Atieh, Steven Leichter, Charles Meadows, David Hotchkiss, Mazen Abu-Fadel, Alan Wiseman, Jeffrey Bander, Mahesh Shah, Subhash Banerjee, Ricky Ganim, Karen Sopko, Misal Khan, Ramon Lloret, Troy Weirick, Rajendra Mehta, Udho Thadani, Anuj Bhargava, Mikhail Kosiborod, Jaynier Moya, Cezar Staniloae, Yamirka D Guerra, Anil Chhabra, Douglas Kosmicki, Wassim Shaheen, Akber Mohammed, J'Cinda Bitters, Jan Pattanayak, Julian Javier, Sunny Srivastava, Roland Phillips, Jessie Al-Amin, Michael Lillestol, Patrick Simpson, Lydie Hazan, Amit Amin, Gopi Shah, Denes Korpas, Bruce Platt, Jim Dickert, Orlando Puente, Louis Hiotis, Timothy Doyle, Raj Rajan, Alan Meholick, Christian Gring, Elie Hage-Korban, Robert Feldman, Harry Colfer, Samuel Butman, Malcolm Foster, Terence Hart, Randall Huling, Shervin Eshaghian, Ofsman Quintana, Deanna Cheung, Franklin Handel, Mara Rodriguez, David Suh, Paul Gordon, Gregg Pressman, Michael Bauer, William French, Mark Barettella, Sridhar Chatrathi, Damodhar Suresh, Ronald Goldberg, Mark Huth, Liwa Younis, Aref Rahman, Richard Mascolo, Michelle Welch, Randeep Suneja, Stephen Smith, Scott Shurmur, John Agaiby, Ahmad Jingo, Janice Johnston, Mary Beth, Anthony Vlastaris, Susan Kemp, Hamid Taheri, Edward Pereira, Michael Deyoung, Zafir Hawa, Ray Smith, Thomas Galski, Samer Garas, M Reddy, Susheel Sharma, Joeseph Hargrove, Charles Treasure, Ronald Emerson, Tariq Haddad, Kathryn Rohr, Larry Levinson, Raul Gaona, Barry Uretsky, Hiralal Maheshwari, Denny Lee, Stephanie Kinnaman, Robert Singal, Jeffrey Geohas, Osvaldo Gigliotti, Ajit Raisinghani, Charanjit Khurana, Brent Hella, Michael Kelberman, Steven Voyce, Sanjay Singh, Eric Lo, Pradeep Singh, Ross Goodfellow, Stuart Fischer, Richard Lorraine, Traci Turner, Jeffrey Shanes, Robert Busch, Robert Broker, Michelle Zaniewski, Kevin Pounds, Giselle Debs-Perez, Stephen Ong, Brad Frandsen, Douglas Fullington, Naseem Jaffrani, Ahtaram Khan, Marcus Lee, Joe Pouzar, George Revtyak, Julian Gonzalez, Samer Nakhle, Abel Murillo, Douglas Young, Sashi Makam, Mushtaq Syed, Kevin Woolf, Paul Grena, Sarab Alfata, Sharan Mahal, David Hoffman, Tinoy Kizhakekuttu, Joseph Deering, Janak Bhavsar, Scott Mikesell, William Wilson, Vance Wilson, Salah El, Francis Spinale, Vinod Kannarkat, Sunder Rao, Lenita Hanson, John Bertsch, Elena Gonzalez-Ortiz, Norma Severino, John Willis, Joel Schock, Ladan Bakhtari, Raul Gazmuri, Saadat Ansari, Jason Hall, Arvind Mehta, Neal Shealy, Stuart Zarich, Deovrat Singh, Kishor Vora, Nabil Andrawis, Darron Molter, David Maron, Jose Cardona, Ronald D'Agostino, Tamjeed Arshad, Rodney Samaan, David Jones, Dale Presser, John Heath, Sandy Green, George Bittar, Sheldon Henry, David Korn, John Schmedtje, Venkatesh Nadar, Bruce Graham, Ajay Labroo, Leonardo Clavijo, Hal Roseman, Gilbert Ledesma, Robert Rosen, Isaac Dor, William Kirby, Jennefer Sutton, Frank Eder, Bruce Iteld, Jose Gomez-Cortes, Maurice Buchbinder, Joseph Kasper, Antonio Terrelonge, Gustavo Torres, Ted Jagielo, Jose Alvarez, Yehuda Handelsman, Mario Guillen, Randall Richwine, Lorena Lewy-Alterbaum, Clinton Corder, Moogali Arvind, David Bolshoun, Magdy Mikhail, Stephen Minton, Odilon Alvarado, J Abbott, Brett Cauthen, Ryan Welter, Randy Mintz, John Cox, Annette Quick, Melvin Weiss, Johnny Dy, James Zebrack, Glenn Gandelman, Vinayak Hegde, Marc Silver, Michele DeGregorio, William Lawson, Christopher Paa, Anna Bortnick, Merrill Krolick, Rodolfo Sotolongo, Jorge Cheirif, Priya Kumar, Preetham Jetty, Ambar Patel, Mariusz Kruk, Iwona Kobielusz-Gembala, Barbara Rewerska, Adam Madrzejewski, Krzysztof Milewski, Jerzy Cygler, Joanna Petryka-Mazurkiewicz, Waldemar Jastrzebski, Janusz Korecki, Wojciech Fil, Janusz Prokopczuk, Anna Bochenek, Marek Wujkowski, Robert Witek, Piotr Konczakowski, Pawel Miekus, Marcin Szczasny, Wlodzimierz Musial, Krzysztof Cymerman, Jacek Lampart, Jacek Mikosinski, Slawomir Szynal, Issa Fares, Grzegorz Opolski, Stanislaw Mazur, Beata Wozakowska-Kaplon, Renata Bijata-Bronisz, Lukasz Wierucki, Beata Losa, Grzegorz Drelich, Marek Konieczny, Pawel Starczewski, Lidia Pawlowicz, Pawel Jesionowski, Jaroslaw Jurowiecki, Jacek Gniot, Mariusz Czyzycki, Karol Stania, Izabela Kucharczyk-Bauman, Benita Busz-Papiez, Agnieszka Karczmarczyk, Wanda Sudnik, Alina Koszek, Piotr Kolodziej, Bartosz Skwarna, Nicolás Jaramillo, Maciej Jankowski, Wojciech Czochra, Leszek Kinasz, Beata Miklaszewicz, Teresa Stasinska, Wladyslaw Pluta, Marcin Basiak, Teresa Rusicka, Izabela Niedbal-Yahfouf, Grazyna Popenda, Romuald Korzeniak, Agnieszka Mirek, Rafal Mariankowski, Lukasz Wojnowski, Marek Korol, Jacek Baszak, Piotr Podolec, Wojciech Piesiewicz, Aleksander Zurakowski, Carlos Luengas, Marek Skura, Piotr Pilecki, Piotr Majchrzak, Ewa Krzyzagórska, Marcin Drozd, Barbara Kaczmarek, Teresa Sliwinska, Katarzyna Zelazowska, Rafal Sztembis, Katarzyna Landa, Lidia Matyszczak-Toniak, Krzysztof Strojek, Marek Piepiorka, Robert Malinowski, Maria Górska, Edyta Stolarczyk-Sowa, Leszek Romanowski, Elzbieta Zinka, Zygfryd Reszka, Joanna Skierkowska, Anna Uzunow, Ewa Laskowska-Derlaga, Ekaterina Puntus, Elena D Kosmacheva, Natalia Koziolova, Prokhor Pavlov, Tatiana Supryadkina, Yury Didenko, Philipp Kopylov, Andrei Kazakov, Sergei Aksentiev, Elena Vishneva, Alexey Repin, Olga Smolenskaya, Olga Mantserova, Oleg Khrustalev, Elena Privalova, Vladimir Konstantinov, Svetlana Boldueva, Andrey Ezhov, Alexander Chernyavsky, Gadel Kamalov, Albert Galyavich, Galina Zubeeva, Galina Nechaeva, Sergey Shustov, Nino Dzhaiani, Tatiana Treshkur, Nataliya Osokina, Alexey Panov, Elena Shutemova, Valeriy Makukhin, Tatiana Kropotina, Larisa Tsyba, Yuri Karpov, J M Sizova, Marina Ballyuzek, Nikolay Tarasov, Elena Demchenko, Olga Barbarash, Valentin Moiseev, Valentin Markov, Vadim Kuznetsov, Inna Viktorova, Igor Sergienko, Lyudmila Ermoshkina, Niyaz Khasanov, Tatiana Khlevchuk, Andrey Baglikov, Sergey Shalaev, Elena Zonova, Elena Reznik, Larisa Haisheva, Tatyana Morugova, Nikita Lomakin, Alexander Vishnevsky, Yuri Shvarts, Olga Magnitskaya, Marina Mikhailusova, Elena Pavlysh, Igor Libov, Anna Zateyschikova, Victor Kostenko, Anton Edin, Yaroslava Khovaeva, Konstantin Zakharov, Raisa Stryuk, Vladimir Khirmanov, Sergey Kanorskiy, Sergey Yakushin, Anna Barabashkina, Hongwei Li, Qiang Zhao, Jian Zhang, Jianhua Ma, Yong He, Ming Luo, Aidong Zhang, Ningru Zhang, Yingru Chai, Genshan Ma, Hao Wang, Zhigang Liu, Lanjie He, Zhifang Song, Xiaolin Dong, Liang Tao, Zhanquan Li, Xi Su, Xiangqing Kong, Heping Niu, Junbo Ge, Zhurong Luo, Wenjun Huang, Daoquan Peng, Zuyi Yuan, Maria Milanova, Doncho Tenev, Antoni Gogov, Dimitar Karageorgiev, Todor Kolchev, Nikolay Rusev, Nikolina Georgieva, Rumen Kondov, Veselin Rusinov, Ivo Petrov, Georgi Stanchev, Mariana Konteva, Adriana Dincheva, Zdravka Yaneva, Ralitsa Vatova, Katya Ilieva, Nikolai Runev, Borislav Kolomanov, Ivan Petrov, Nikolay Iliev, Snezhanka Tisheva, Boryana Chompalova, Maria Tokmakova, Dimitar Raev, Kolyo Byanov, Dimitar Markov, Lenko Mihov, Atanas Mihov, Nora Milcheva, Milen Minchev, Mihail Mollov, Borislav Borisov, Tihomir Tihchev, Venelin Karakolev, Bojidar Dimov, Svetoslav Georgiev, Lachezar Smilov, Bon K Koo, Taehoon Ahn, Soon J Hong, Junghan Yoon, Seok K Oh, Myung H Jeong, Doo-Il Kim, Kiyuk Chang, Weon Kim, Joo-Yong Hahn, Kwang S Cha, Jung-Hee Lee, Si-Wan Choi, Chang-Wook Nam, In-Ho Chae, Yong H Park, Seung-Jea Tahk, Won-Yong Shin, Jei-Keon Chae, Byung J Kim, Jang-Whan Bae, Woo J Park, Seung W Rha, Young J Choi, Jin-Yong Hwang, Hun S Park, Luciano Baracioli, Fabio Guimaraes, Eduardo Vasconcellos, José Saraiva, Adamastor Pereira, Queulla Santos, Paulo Rossi, Lilia Maia, Miguel Madeira, Marcio Pereira, Roberto Botelho, Gilmar Reis, Freddy Eliaschewitz, Joao Borges, Carlos Nascimento, Jose A Fortes, Weimar de Souza, Pedro Pimentel, Miguel Hissa, Marcos Franchetti, Dalton Precoma, Costantino Ortiz, Mauro Hernandes, Wladmir Saporito, Fabio R dos Santos, Adrian Kormann, Fernando Neuenschwander, Oscar Dutra, Nelson Rassi, Luiz Tanajura, Juliana Souza, Delcio S Junior, Paulo Leaes, Adriana Forte, Teresa C Bonansea, Jose Marin, Bruno Machado, Maria J Cerqueira, Frederico Silva, Yorghos Michalaros, Euler Manenti, Cintia Cercato, Estevao Figueiredo, Ming-En Liu, Yi-Chih Wang, Tsung-Ming Lee, Chih Fang, Yen-Wen Wu, Kwo-Chang Ueng, Huey-Herng Sheu, Wen T Lai, I-Chang Hsieh, Zhih-Cherng Chen, Mu-Jang Lee, Chern Chiang, Kou-Gi Shyu, Chien-Hsun Hsia, Guang-Yuan Mar, Shih-Hung Chan, Chih-Cheng Wu, Wei-Kung Tseng, Kuan-Cheng Chang, Hung-I Yeh, Ji-Hung Wang, Charles Hou, Inna Sorokina, Maryna Dolzhenko, Olha Horoshko, Oleksandr Karpenko, Leonid Rudenko, Igor Vakaliuk, Anna Kulyk, Olena Levchenko, Oleksandr Prokhorov, Dmytro Reshotko, Mykhaylo Sorokivskyy, Nataliia Velichko, Valentyn Maslovskyi, Zinaida Teliatnikova, Sergiy Dotsenko, Olena Krakhmalova, Igor Kraiz, Viktoria Zharinova, Larysa Bula, Igor Kaydashev, Valeriy Molodtsov, Lesya Rasputina, Viktoriya Pidlisna, Olena Lysunets, Anatoliy Kravchenko, Liubomyr Glushko, Tetyana Khomazyuk, Yevgeniya Svyshchenko, Oleksandr Parkhomenko, Boris Mankovsky, Orest Abrahamovych, Andriy Yagensky, Mykola Stanislavchuk, Larisa Vasilyeva, Liubov Sokolova, Oleg Sychov, Vira Tseluyko, Igor Kyrychenko, Mykola Rishko, Sergiy Furkalo, Richard Gallo, Olivier Bertrand, Shamir Mehta, Christian Constance, Bruce Sussex, Remo Zadra, Simon Kouz, Raja Chehayeb, Amritanshu Pandey, Danielle Dion, Gordon Bailey, Laurie Hill, Krishnan Ramanathan, Micha Dorsch, Alykhan Nanji, Mohan Babapulle, Martine Montigny, Gilbert Gosselin, Payam Dehghani, Dennis Rupka, Michel Le May, Francis Pichette, Francois St-Maurice, Patrick Teefy, Samer Mansour, Saleem Kassam, Stephen Cheung, Anthony D Siega, Dennis O'Keefe, Eric Sabbah, Alan Bell, Guy Chouinard, Brian Wong, Mark Miller, Daniel Gaudet, Pierre Lachance, Iqbal Bata, Robert Petrella, Denis Gossard, Richard Dumas, Douglas Ing, Hagop Boyrazian, Ricardo Bessoudo, Thao T Huynh, Randy Hart, Jasmin Belle-Isle, Dinkar Shukla, Allan Kelly, Giuseppe Mazza, James Cha, Sam Henein, Andre Frechette, Saul Vizel, Joanne F Liutkus, Michael O'Mahony, Frank Halperin, Jacobus Kooy, John Graham, Allan Bailey, Ronald Wojcik, Igor Wilderman, Tibor Turi, Ákos Motyovszki, Béla Merkely, Csaba Király, Péter Andrássy, Zsolt Sárszegi, Tibor Fülöp, Zsolt Zilahi, István Édes, Andras Papp, Gábor Müller, Anna Czigány, Szilárd Zólyomi, László Korányi, János Takács, Ferenc Juhász, Bela Benczur, Sándor Kancz, András Földi, András C Nagy, Judit Bakai, István Greschik, László Püski, László Nagy, Róbert Kirschner, Roman Kuchar, Petr Hajek, Ladislav Busak, Daniel Michalik, Ivo Matyasek, Ivana Marusincova, Dusan Kucera, Ondrej Jerabek, Michaela Honkova, Vratislav Dedek, Ivan Rihacek, Pavel Kos, Josef Slaby, Martina Machkova, Eva Zidkova, Lubomir Elbl, Hana Grunfeldova, Jiri Carda, Vladimir Mrozek, Jiri Maly, Richard Milkovic, Jan Malecha, Hana Skalicka, Ivo Oral, Eva Krcova, Libor Lisa, Jan Belohlavek, Roman Miklik, Ondrej Cermak, Jana Bednarova, Zdenek Peroutka, Jindrich Spinar, Andreas Wilke, Karl-Friedrich Appel, Jens Taggeselle, Andreas Förster, Nicole Toursarkissian, Ekkehard Schmidt, Jochen Bott, Ayham Al-Zoebi, Dirk Hennig, Sabine Fischer, Norbert Schön, Joachim Sauter, Gregor Simonis, Ruth Nischik, Werner Rieker, Isabelle Schenkenberger, Thomas Behnke, Gerhard Klausmann, Michael Jeserich, Dietmar Trenk, Ingo Weigmann, Hannes Reuter, Reinhard Rummel, Candy von Münchhausen, Charlotte von Engelhardt, Eishun Horibe, Taro Shibasaki, Tomohiko Sato, Tsunekazu Kakuta, Ichiro Michishita, Michinao Tan, Ryoji Ishiki, Takahiko Aoyama, Shinichi Higashiue, Yawara Niijima, Akira Idogaki, Toru 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Giovanni Amoroso, Gabriela Carnero, Ernesto Duronto, Diego Besada, Carolina Chacon, Pedro Zangroniz, Silvana Solis, Alberto Liberman, Virginia Sernia, Andres Alvarisqueta, Laura Maffei, Oscar G Vilamajo, Celso García, Maximiliano Sicer, Juan Muntaner, Anselmo Bordonava, Juan Albisu, Alejandra Zanini, Lucas Rista, Miguel Hominal, José N Estrada, Aldo Prado, Diego M Gosparini, Beatriz Schiavi, Armando G Castillo, José G Ruíz, Guillermo R Martinez, Víctor G López, Enrique L Rosas, Gabriel R Lopez, Elias G Cantu, Manuel de los Ríos Ibarra, Francisco P Padilla, Jose P Carrasco, Luis V Carrillo, Joel D García, Alfredo N Askar, Carlos A Salinas, Marco A Gamba, Carlos G Sanchez, Arnulfo G Cantú, Raul V Sánchez, Jaime C Madrigal, Rafael H Urbano, Andrés Í Romo, José R González Juanatey, Paolo Racugno, Angel C Fillat, José M de la Torre Hernández, Juan A Peláez, Jorge B Cortada, Pablo G Pavia, Manuel J Navarro, Roberto M Asenjo, Francisco F Díaz, Eduard B Peligero, Fernando A Manterola, Antonio 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Nicolas Danchin, Denis Angoulvant, Emile Ferrario, Meyer Elbaz, Olivier Dubreuil, Philippe G Steg, Caroline Fontaine, Emmanuel Sorbets, Hafiz Omer, Shukri Al-Saif, Hussam Al-Faleh, Abdullah Al-Shehri, Halia Alshehri, Rasha Bazari, Pak Hei, Man Ying, Michael Chan, Michelle Wong, Ronald Ma, Shing C Siu, Chiu C Tsang, Maurizio Ferrario, Emilio Assanelli, Michele Senni, Piermarco Piatti, Paolo Calabrò, Stefano Urbinati, Massimo Michisanti, Ferdinando Varbella, Salvatore de Cosmo, Roberto Trevisan, Sandro Bellotti, Giuseppe Di Pasquale, Angelo S Bongo, Massimo Uguccioni, Edoardo Mannucci, Ciro Mauro, Mauro Ragonese, Claudio Fresco, Maurizio Turturo, Rossella Marcucci, Manuel J Lievano Triana, Camilo Arana, Jose Accini, Rodrigo Botero, Marlena Muzyk-Osikowicz, Fredy T Dada, Gregorio S Vallejo, Fernando Manzur, Daniel Isaza, Dora Molina, Juan G Mesa, Alvaro Quintero, Kai Nyman, Jyrki Mäkelä, Jorma Strand, Sakari Nieminen, Jyrki Taurio, Matti Kuusela, Timo Valle, Mikko Pietilä, Sakari Kekki, 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Chern-En Chiang, Alexander Parkhomenko, Tuan Q Nguyen, Maria Leonsson-Zachrisson, Herrada, Anthony, Brigham & Women’s Hospital [Boston] (BWH), Harvard Medical School [Boston] (HMS), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Royal Brompton Hospital, McMaster University [Hamilton, Ontario], Keenan Research Centre of the Li Ka Shing Knowledge Institute [Toronto], St. Michael's Hospital, University of Toronto, Service de Pharmacologie médicale = service de pharmacologie - Dosage de médicaments [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Uppsala University Hospital, Uppsala Universitet [Uppsala], AstraZeneca, Tokai University, Uppsala University, Imperial College London, Saint Luke's Mid America Heart Institute, University of Missouri [Kansas City] (UMKC), University of Missouri System, University of New South Wales [Sydney] (UNSW), University of Texas Southwestern Medical Center [Dallas], Stanford University, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Université de Montpellier (UM), Bhatt, D, Steg, P, Mehta, S, Leiter, L, Simon, T, Fox, K, Held, C, Andersson, M, Himmelmann, A, Ridderstrale, W, Chen, J, Song, Y, Diaz, R, Goto, S, James, S, Ray, K, Parkhomenko, A, Kosiborod, M, Mcguire, D, Harrington, R, Santos, V, Jain, A, Lendel, I, Russo, M, Haught, W, Bouza, M, Gogia, H, Banerjee, S, Kichura, G, Kantaros, L, Padron, F, Passi, R, Stone, J, Pursley, M, D'Urso, M, Gardner, T, Bennett, J, Nour, K, Saini, S, Zhang, W, Kumbhani, D, Thomas, D, Angiolillo, D, Bertolet, B, Roman-Miranda, A, Black, R, Manshadi, R, Vaca, C, Blanco, A, Napoli, M, Brabham, D, Akyea-Djamson, A, Desai, P, Prasada, S, Khaira, A, Forgosh, L, Lieber, I, Umpierrez, G, Singal, D, Londono, J, Fraser, N, Ruiz, J, Vega, D, Rodriguez, L, Brown, C, Syed, F, Aggarwala, G, Eaves, W, Foster, M, Gupta, D, Avino, D, Asfour, W, Tonnessen, G, Zhao, X, Singh, N, Brockmyre, A, Lepor, N, Shammas, N, Blick, D, Hearne, S, Prodafikas, J, Carell, E, Izzo, M, Karim, A, Zakhary, B, Atieh, M, Leichter, S, Meadows, C, Hotchkiss, D, Abu-Fadel, M, Wiseman, A, Bander, J, Shah, M, Ganim, R, Sopko, K, Khan, M, Lloret, R, Weirick, T, Mehta, R, Thadani, U, Bhargava, A, Moya, J, Staniloae, C, Guerra, Y, Chhabra, A, Kosmicki, D, Shaheen, W, Mohammed, A, Bitters, J, Pattanayak, J, Javier, J, Srivastava, S, Phillips, R, Al-Amin, J, Lillestol, M, Simpson, P, Hazan, L, Amin, A, Shah, G, Korpas, D, Platt, B, Dickert, J, Puente, O, Hiotis, L, Doyle, T, Rajan, R, Meholick, A, Gring, C, Hage-Korban, E, Feldman, R, Colfer, H, Butman, S, Hart, T, Huling, R, Eshaghian, S, Quintana, O, Cheung, D, Handel, F, Rodriguez, M, Suh, D, Gordon, P, Pressman, G, Bauer, M, French, W, Barettella, M, Chatrathi, S, Suresh, D, Goldberg, R, Huth, M, Younis, L, Rahman, A, Mascolo, R, Welch, M, Suneja, R, Smith, S, Shurmur, S, Agaiby, J, Jingo, A, Johnston, J, Beth, M, Vlastaris, A, Kemp, S, Taheri, H, Pereira, E, Deyoung, M, Hawa, Z, Smith, R, Galski, T, Garas, S, Reddy, M, Sharma, S, Hargrove, J, Treasure, C, Emerson, R, Haddad, T, Rohr, K, Levinson, L, Gaona, R, Uretsky, B, Maheshwari, H, Lee, D, Kinnaman, S, Singal, R, Geohas, J, Gigliotti, O, Raisinghani, A, Khurana, C, Hella, B, Kelberman, M, Voyce, S, Singh, S, Lo, E, Singh, P, Goodfellow, R, Fischer, S, Lorraine, R, Turner, T, Shanes, J, Busch, R, Broker, R, Zaniewski, M, Pounds, K, Debs-Perez, G, Ong, S, Frandsen, B, Fullington, D, Jaffrani, N, Khan, A, Lee, M, Pouzar, J, Revtyak, G, Gonzalez, J, Nakhle, S, Murillo, A, Young, D, Makam, S, Syed, M, Woolf, K, Grena, P, Alfata, S, Mahal, S, Hoffman, D, Kizhakekuttu, T, Deering, J, Bhavsar, J, Mikesell, S, Wilson, W, Wilson, V, El, S, Spinale, F, Kannarkat, V, Rao, S, Hanson, L, Bertsch, J, Gonzalez-Ortiz, E, Severino, N, Willis, J, Schock, J, Bakhtari, L, Gazmuri, R, Ansari, S, Hall, J, Mehta, A, Shealy, N, Zarich, S, Singh, D, Vora, K, Andrawis, N, Molter, D, Maron, D, Cardona, J, D'Agostino, R, Arshad, T, Samaan, R, Jones, D, Presser, D, Heath, J, Green, S, Bittar, G, Henry, S, Korn, D, Schmedtje, J, Nadar, V, Graham, B, Labroo, A, Clavijo, L, Roseman, H, Ledesma, G, Rosen, R, Dor, I, Kirby, W, Sutton, J, Eder, F, Iteld, B, Gomez-Cortes, J, Buchbinder, M, Kasper, J, Terrelonge, A, Torres, G, Jagielo, T, Alvarez, J, Handelsman, Y, Guillen, M, Richwine, R, Lewy-Alterbaum, L, Corder, C, Arvind, M, Bolshoun, D, Mikhail, M, Minton, S, Alvarado, O, Abbott, J, Cauthen, B, Welter, R, Mintz, R, Cox, J, Quick, A, Weiss, M, Dy, J, Zebrack, J, Gandelman, G, Hegde, V, Silver, M, Degregorio, M, Lawson, W, Paa, C, Bortnick, A, Krolick, M, Sotolongo, R, Cheirif, J, Kumar, P, Jetty, P, Patel, A, Kruk, M, Kobielusz-Gembala, I, Rewerska, B, Madrzejewski, A, Milewski, K, Cygler, J, Petryka-Mazurkiewicz, J, Jastrzebski, W, Korecki, J, Fil, W, Prokopczuk, J, Bochenek, A, Wujkowski, M, Witek, R, Konczakowski, P, Miekus, P, Szczasny, M, Musial, W, Cymerman, K, Lampart, J, Mikosinski, J, Szynal, S, Fares, I, Opolski, G, Mazur, S, Wozakowska-Kaplon, B, Bijata-Bronisz, R, Wierucki, L, Losa, B, Drelich, G, Konieczny, M, Starczewski, P, Pawlowicz, L, Jesionowski, P, Jurowiecki, J, Gniot, J, Czyzycki, M, Stania, K, Kucharczyk-Bauman, I, Busz-Papiez, B, Karczmarczyk, A, Sudnik, W, Koszek, A, Kolodziej, P, Skwarna, B, Jaramillo, N, Jankowski, M, Czochra, W, Kinasz, L, Miklaszewicz, B, Stasinska, T, Pluta, W, Basiak, M, Rusicka, T, Niedbal-Yahfouf, I, Popenda, G, Korzeniak, R, Mirek, A, Mariankowski, R, Wojnowski, L, Korol, M, Baszak, J, Podolec, P, Piesiewicz, W, Zurakowski, A, Luengas, C, Skura, M, Pilecki, P, Majchrzak, P, Krzyzagorska, E, Drozd, M, Kaczmarek, B, Sliwinska, T, Zelazowska, K, Sztembis, R, Landa, K, Matyszczak-Toniak, L, Strojek, K, Piepiorka, M, Malinowski, R, Gorska, M, Stolarczyk-Sowa, E, Romanowski, L, Zinka, E, Reszka, Z, Skierkowska, J, Uzunow, A, Laskowska-Derlaga, E, Puntus, E, Kosmacheva, E, Koziolova, N, Pavlov, P, Supryadkina, T, Didenko, Y, Kopylov, P, Kazakov, A, Aksentiev, S, Vishneva, E, Repin, A, Smolenskaya, O, Mantserova, O, Khrustalev, O, Privalova, E, Konstantinov, V, Boldueva, S, Ezhov, A, Chernyavsky, A, Kamalov, G, Galyavich, A, Zubeeva, G, Nechaeva, G, Shustov, S, Dzhaiani, N, Treshkur, T, Osokina, N, Panov, A, Shutemova, E, Makukhin, V, Kropotina, T, Tsyba, L, Karpov, Y, Sizova, J, Ballyuzek, M, Tarasov, N, Demchenko, E, Barbarash, O, Moiseev, V, Markov, V, Kuznetsov, V, Viktorova, I, Sergienko, I, Ermoshkina, L, Khasanov, N, 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Frechette, A, Vizel, S, Liutkus, J, O'Mahony, M, Halperin, F, Kooy, J, Graham, J, Bailey, A, Wojcik, R, Wilderman, I, Turi, T, Motyovszki, A, Merkely, B, Kiss, R, Kiraly, C, Andrassy, P, Sarszegi, Z, Fulop, T, Zilahi, Z, Edes, I, Papp, A, Muller, G, Czigany, A, Zolyomi, S, Koranyi, L, Takacs, J, Juhasz, F, Benczur, B, Kancz, S, Foldi, A, Nagy, A, Bakai, J, Greschik, I, Puski, L, Nagy, L, Kirschner, R, Kuchar, R, Hajek, P, Busak, L, Michalik, D, Matyasek, I, Marusincova, I, Kucera, D, Jerabek, O, Honkova, M, Dedek, V, Rihacek, I, Kos, P, Slaby, J, Machkova, M, Zidkova, E, Elbl, L, Grunfeldova, H, Carda, J, Mrozek, V, Maly, J, Milkovic, R, Malecha, J, Skalicka, H, Oral, I, Krcova, E, Lisa, L, Belohlavek, J, Miklik, R, Cermak, O, Bednarova, J, Peroutka, Z, Spinar, J, Wilke, A, Appel, K, Taggeselle, J, Forster, A, Toursarkissian, N, Schmidt, E, Bott, J, Al-Zoebi, A, Hennig, D, Schon, N, Sauter, J, Simonis, G, Nischik, R, Rieker, W, Schenkenberger, I, Behnke, T, Klausmann, G, Jeserich, M, Trenk, D, Weigmann, I, Reuter, H, Rummel, R, von Munchhausen, C, von Engelhardt, C, Horibe, E, Shibasaki, T, Sato, T, Kakuta, T, Michishita, I, Tan, M, Ishiki, R, Aoyama, T, Higashiue, S, Niijima, Y, Idogaki, A, Hasegawa, T, Kiyosue, A, Tomobuchi, Y, Kawamitsu, K, Kawasaki, S, Hata, Y, Fukui, K, Seki, K, Takenaka, T, Abe, M, Utsu, N, Oono, A, Mitsuo, K, Sueyoshi, A, Hirohata, A, Tsujimoto, M, Ueda, O, Takase, S, Suzuki, M, Sakuragi, S, Yamamoto, F, Fujimoto, N, Kakinoki, S, Sugiura, T, Sugino, H, Nakamura, T, Kadokami, T, Uehara, H, Ono, M, Yokoya, K, Koike, A, Komatsu, S, Sonoda, M, Ueno, H, Doi, T, Takagi, Y, Fujimoto, K, Eki, Y, Okubo, M, Sasaki, K, van Eck, M, Ronner, E, The, S, van de Wal, R, Nierop, P, de Nooijer, C, Werner, H, Westendorp, I, van der Zwaan, C, Crijns, H, Cornel, J, Strikwerda, S, Bos, R, de Melker, E, Kuijper, A, Louwerenburg, H, Plomp, J, Dantzig, J, Prins, F, van Kesteren, H, Willems, F, Amoroso, G, Carnero, G, Duronto, E, Besada, D, Chacon, C, Zangroniz, P, Solis, S, Liberman, A, Sernia, V, Alvarisqueta, A, Maffei, L, Vilamajo, O, Garcia, C, Sicer, M, Muntaner, J, Bordonava, A, Albisu, J, Zanini, A, Rista, L, Hominal, M, Estrada, J, Prado, A, Gosparini, D, Schiavi, B, Castillo, A, Martinez, G, Lopez, V, Rosas, E, Lopez, G, Cantu, E, de los Rios Ibarra, M, Padilla, F, Carrasco, J, Carrillo, L, Garcia, J, Askar, A, Salinas, C, Gamba, M, Sanchez, C, Cantu, A, Sanchez, R, Madrigal, J, Urbano, R, Romo, A, Gonzalez Juanatey, J, Racugno, P, Fillat, A, de la Torre Hernandez, J, Pelaez, J, Cortada, J, Pavia, P, Navarro, M, Asenjo, R, Diaz, F, Peligero, E, Manterola, F, Ortiz, A, Mediavilla Garcia, J, Ortuno, F, Vera, T, Gonzalez, A, Vinas, J, Fernandez Portales, F, Mayordomo, P, Ojeda, F, Dominguez, A, Gonzalez, R, Guerrero, D, Ruiz Nodar, J, Marimon, X, Margaez, J, Aguilera, R, Diaz Fernandez, J, Zamorano Gomez, J, Gonzalez, V, del Blanco, B, Perez, I, Moreno, M, Ereno, A, Garcia Lledo, J, Prieto, J, Villablanca, A, Raffo, C, Pincetti, C, Conejeros, C, Roman, O, Varleta, P, Goldberg, C, Sandoval, J, Arriagada, G, Corbalan, R, Leon, L, Potthoff, S, Cobos, J, Figueroa, C, Makotoko, E, Fourie, N, Burgess, L, Nortje, H, Theron, R, Pillai, P, Ranjith, N, Trokis, J, Pillay, S, Reddy, J, Nunkoo, T, Kapp, C, Urbach, D, Distiller, L, Horak, A, van Zyl, L, Coetzee, K, Punt, Z, Bayat, J, Dawood, S, Mitha, I, Padayachee, T, Hoosen, F, Dalby, A, Prabhavathi, Gowdaiah, P, Mehta, V, Chag, M, Gadkari, M, Ramamurthee, K, Das, A, Sawhney, J, Sathe, P, Adhyapak, S, Nguyen, T, Pham, V, Do, H, Nguyen, A, Nguyen, H, Truong, B, Jamil-Copley, S, Lang, C, Pell, A, Zaman, A, Storey, R, Swanson, N, Sharman, D, Braganza, D, Hammond, P, Moriarty, A, Bain, S, Pye, M, Sharp, A, Blagden, M, Randeva, H, Myhill, T, Viswanathan, G, Keeling, P, Clifford, P, Saxena, M, Lyons, K, Mcmurray, J, Jaafar, F, Murphy, C, Cartwright, S, Abouglila, K, Antalik, L, Krajci, P, Urban, M, Fazekas, F, Pella, D, Koleny, D, Vykoukalova, T, Macek, V, Vinanska, D, Jamriskova, L, Such, S, Fulop, P, Farsky, S, Bugan, V, Strbova, J, Micko, K, Palka Jr, J, Sivak, V, Kristensen, D, Refsgaard, J, Holmvang, L, Dixen, U, Nielsen, H, Egstrup, K, Jensen, L, Sykulski, R, Rasmussen, O, Andries, A, Luckow, A, Nielsen, G, Sorensen, T, Wongvipaporn, C, Chamnarnphol, N, Srimahachota, S, Sansanayudh, N, Kuanprasert, S, Tresukosol, D, Sookananchai, B, Kanadasi, M, Ozcan, T, Kucuk, M, Ongen, Z, Okuyan, E, Arat, A, Acikel, S, Yalcin, A, Guray, U, Ceyhan, C, Ozer, N, Arslan, S, Angeras, O, Johnston, N, Weiderman, A, Bandh, S, Hansen, O, Larnefeldt, H, Kusiak, D, Lindholm, C, Hedman, A, Erlinge, D, Curiac, D, Lundman, P, Zucconi-Mazzini, R, Aladellie, L, Jensen, J, Verwerft, J, Vrolix, M, Faes, D, Striekwold, H, Sinnaeve, P, Timmermans, P, Guedes, A, Delforge, M, Nimmegeers, J, Stammen, F, Buysschaert, I, Hoffer, E, Hollanders, G, Vervoort, G, Coussement, P, de Maeseneire, S, Janssens, L, Gravdal, S, Risberg, K, Gullestad, L, Hofseth, O, Nilsen, D, Lappegard, K, van den Heuvel, C, Gibbs, C, Khusrawi, A, Arora, S, Tomala, T, Kjaernli, T, Berg-Johansen, J, Hagemeier, R, Skjelvan, G, Colquhoun, D, Amerena, J, Morbey, C, Hammett, C, Dart, A, Lehman, R, Hamilton, A, Worthley, M, Purnell, P, Whelan, A, Macisaac, R, Arya, K, Linjawi, S, Proietto, J, Prasad, L, Rodriguez, A, Godoy, A, Rodriguez, V, Berrospi, P, Chavez, C, Negron, S, Heredia, J, Medina, F, Manrique, H, Cabrera, W, Cordova, F, Quinteros, T, Haro, J, Regalado, S, Guitton, J, Arbanil, H, Pansieri, M, Decoulx, E, Goube, P, de Labriolle, A, Labeque, J, Range, G, Cottin, Y, Montalescot, G, Cayla, G, Danchin, N, Angoulvant, D, Ferrario, E, Elbaz, M, Dubreuil, O, Fontaine, C, Sorbets, E, Omer, H, Al-Saif, S, Al-Faleh, H, Al-Shehri, A, El-Amin, O, Alshehri, H, Bazari, R, Hei, P, Ying, M, Chan, M, Wong, M, Ma, R, Siu, S, Tsang, C, Ferrario, M, Assanelli, E, Senni, M, Piatti, P, Calabro, P, Urbinati, S, Michisanti, M, Varbella, F, de Cosmo, S, Trevisan, R, Bellotti, S, Di Pasquale, G, Bongo, A, Uguccioni, M, Mannucci, E, Mauro, C, Ragonese, M, Fresco, C, Turturo, M, Marcucci, R, Lievano Triana, M, Arana, C, Accini, J, Botero, R, Muzyk-Osikowicz, M, Dada, F, Vallejo, G, Manzur, F, Isaza, D, Molina, D, Mesa, J, Quintero, A, Nyman, K, Makela, J, Strand, J, Nieminen, S, Taurio, J, Kuusela, M, Valle, T, Pietila, M, Kekki, S, Strandberg, T, Klutstein, M, Greenberg, G, Rozenman, Y, Chorin, E, Roguin, A, Lewis, B, Bashkin, A, Tan, E, Prado, J, Ferrolino, A, Babilonia, N, Barbas, B, Matiga, G, Coching, R, Drexel, H, Brath, H, Schnack, C, Hanusch, U, Fliesser-Gorzer, E, Paulweber, B, Ebenbichler, C, Prager, R, Huber, K, Wolzt, M, Auer, J, Berger, R, Schernthaner, G, Stanciulescu, G, Creteanu, M, Spiridon, M, Dobreanu, V, Vinereanu, D, Iosipescu, L, Istratoaie, O, Coman, I, Militaru, C, Cinteza, M, Nicolau, J, Kerr Saraiva, J, Widimsky, P, Kristensen, S, Hartikainen, J, Darius, H, Tse, H, Pais, P, Lev, E, de Luca, L, Ramos Lopez, G, Kontny, F, Zateyshchikov, D, Ruda, M, Elamin, O, Kovar, F, Bueno, H, Leonsson-Zachrisson, M, Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de pharmacologie - Dosage de médicaments [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), and Royal Brompton and Harefield NHS Foundation Trust-Imperial College London
Subjects: Male, Platelet Aggregation Inhibitors/therapeutic use, THEMIS Steering Committee and Investigators, medicine.medical_treatment, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], 030204 cardiovascular system & hematology, Coronary Angiography, Stroke/epidemiology, Coronary artery disease, DOUBLE-BLIND, 0302 clinical medicine, Hemorrhage/chemically induced, acetylsalicylic acid, antidiabetic agent, placebo, ticagrelor, Secondary Prevention, Medicine, 030212 general & internal medicine, Myocardial infarction, Coronary Artery Bypass, Cardiovascular Diseases/mortality, 11 Medical and Health Sciences, OUTCOMES, Aspirin, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, General Medicine, Middle Aged, Clopidogrel, 3. Good health, Ticagrelor/therapeutic use, DRUG-ELUTING STENTS, CLOPIDOGREL, Cardiology, PLATELET INHIBITION, Drug Therapy, Combination, Female, Life Sciences & Biomedicine, Ticagrelor, TIMI, medicine.drug, Coronary Artery Disease/complications, medicine.medical_specialty, Hypoglycemic Agents/therapeutic use, POOLED ANALYSIS, 03 medical and health sciences, Medicine, General & Internal, Percutaneous Coronary Intervention, Double-Blind Method, General & Internal Medicine, Internal medicine, Myocardial Infarction/epidemiology, Humans, Aged, Science & Technology, ANTIPLATELET THERAPY, business.industry, Diabetes Mellitus, Type 2/complications, ELEVATION MYOCARDIAL-INFARCTION, RIVAROXABAN, Percutaneous coronary intervention, medicine.disease, ASPIRIN, Coronary Stenosis/diagnostic imaging, Aspirin/therapeutic use, Conventional PCI, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Contains fulltext : 215333.pdf (Publisher’s version ) (Closed access) BACKGROUND: Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor. METHODS: The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population). FINDINGS: Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3.3 years (IQR 2.8-3.8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7.3%] of 5558 vs 480 [8.6%] of 5596; HR 0.85 [95% CI 0.74-0.97], p=0.013). The same effect was not observed in patients without PCI (p=0.76, pinteraction=0.16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3.1%] with ticagrelor vs 183 (3.3%) with placebo; HR 0.96 [95% CI 0.78-1.18], p=0.68), as well as all-cause death (282 [5.1%] vs 323 [5.8%]; 0.88 [0.75-1.03], p=0.11). TIMI major bleeding occurred in 111 (2.0%) of 5536 patients receiving ticagrelor and 62 (1.1%) of 5564 patients receiving placebo (HR 2.03 [95% CI 1.48-2.76], p
Published: 2019
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