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Your search keyword '"Greicy Coelho de Souza"' showing total 3 results
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3 results on '"Greicy Coelho de Souza"'

1. Preclinical Evidences for an Antimanic Effect of Carvedilol

Author

Greicy Coelho de Souza, Julia Ariana de S. Gomes, Ana Isabelle de Góis Queiroz, Maíra Morais de Araújo, Lígia Menezes Cavalcante, Michel de Jesus Souza Machado, Aline Santos Monte, David Freitas de Lucena, João Quevedo, André Ferrer Carvalho, and Danielle Macêdo

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Oxidative imbalance, alterations in brain-derived neurotrophic factor (BDNF), and mitochondrial dysfunction are implicated in bipolar disorder (BD) pathophysiology and comorbidities, for example, cardiovascular conditions. Carvedilol (CVD), a nonselective beta-blocker widely used for the treatment of hypertension, presents antioxidant and mitochondrial stabilizing properties. Thus, we hypothesized that CVD would prevent and/or reverse mania-like behavioral and neurochemical alterations induced by lisdexamfetamine dimesylate (LDX). To do this, male Wistar rats were submitted to two different protocols, namely, prevention and reversal. In the prevention treatment the rats received daily oral administration (mg/kg) of CVD (2.5, 5 or 7.5), saline, valproate (VAL200), or the combination of CVD5 + VAL100 for 7 days. From the 8th to 14th day LDX was added. In the reversal protocol LDX was administered for 7 days with the drugs being added from the 8th to 14th day of treatment. Two hours after the last administration the behavioral (open field and social interaction) and neurochemical (reduced glutathione, lipid peroxidation, and BDNF) determinations were performed. The results showed that CVD prevented and reversed the behavioral and neurochemical alterations induced by LDX. The administration of CVD5 + VAL100 potentiated the effect of VAL200 alone. Taken together these results demonstrate a possible antimanic effect of CVD in this preclinical model.

Published
2015
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3. Gastroprotective potential of frutalin, a d-galactose binding lectin, against ethanol-induced gastric lesions

Author

Renato de Azevedo Moreira, Greicy Coelho de Souza, Adriana Rolim Campos, Carolina Araújo Castro, Marjorie M. Guedes, Roberto César Pereira Lima Júnior, Ana Paula Vasconcellos Abdon, Renata Prado Vasconcelos, Ana Cristina de Oliveira Monteiro-Moreira, and Lílian Noronha Coelho de Souza

Subjects
Male, Absolute ethanol, Galectins, Indomethacin, Mice, Inbred Strains, Pharmacology, medicine.disease_cause, Antioxidants, Nitric oxide, Glibenclamide, Mice, chemistry.chemical_compound, Malondialdehyde, Glyburide, Drug Discovery, medicine, Animals, Stomach Ulcer, Cimetidine, Receptor, Ethanol, Voltage-dependent calcium channel, Plant Extracts, Artocarpus incisa, Frutalin, Galactose, General Medicine, Glutathione, Anti-Ulcer Agents, Oxidative Stress, NG-Nitroarginine Methyl Ester, chemistry, Gastric Mucosa, Anesthesia, Capsaicin, Gastroprotection, Capsazepine, Biomarkers, Oxidative stress, Phytotherapy, medicine.drug
Abstract

The present study was designed to verify whether frutalin (FTL) affords gastroprotection against the ethanol-induced gastric damage and to examine the underlying mechanism(s). Gastric damage was induced by intragastric administration of 0.2ml of ethanol (96%). Mice in groups were pretreated with FTL (0.25, 0.5 and 1mg/kg; i.p.), cimetidine (100mg/kg; p.o.), or vehicle (0.9% of NaCl, 10mL/kg; p.o.), 30min before ethanol administration. They were sacrificed 30min later, the stomachs excised, and the mucosal lesion area (mm2) measured by planimetry. Gastroprotection was assessed in relation to inhibition of gastric lesion area. To study the gastroprotective mechanism(s), its relations to capsaicin-sensitive fibers, endogenous prostaglandins, nitric oxide, sulphydryls, ATP-sensitive potassium channels, adrenoceptors, opioid receptors and calcium channels were analyzed. Treatments effects on ethanol-associated oxidative stress markers GSH and MDA were measured in gastric tissue. FTL afforded a dose-unrelated gastroprotection against the ethanol damage. However, it failed to prevent the ethanol-induced changes in the levels of GSH and MDA. It was observed that the gastroprotection by FTL was greatly reduced in animals pretreated with capsazepine, indomethacin, L-NAME or glibenclamide. Considering the results, it is suggested that the FTL could probably be a good therapeutic agent for the development of new medicine for the treatment of gastric ulcer.

Published
2012

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