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4. Canakinumab in patients with COVID-19 and type 2 diabetes – A multicentre, randomised, double-blind, placebo-controlled trial

Author

Hepprich, Matthias, Mudry, Jonathan M., Gregoriano, Claudia, Jornayvaz, Francois R., Carballo, Sebastian, Wojtusciszyn, Anne, Bart, Pierre-Alexandre, Chiche, Jean-Daniel, Fischli, Stefan, Baumgartner, Thomas, Cavelti-Weder, Claudia, Braun, Dominique L., Günthard, Huldrych F., Beuschlein, Felix, Conen, Anna, West, Emily, Isenring, Egon, Zechmann, Stefan, Bucklar, Gabriela, Aubry, Yoann, Dey, Ludovic, Müller, Beat, Hunziker, Patrick, Schütz, Philipp, Cattaneo, Marco, and Donath, Marc Y.

Published
2022
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5. Prospective validation of five malnutrition screening and assessment instruments among medical inpatients: Secondary analysis of a randomized clinical trial

Author

Stalder, Lena, Kaegi-Braun, Nina, Gressies, Carla, Gregoriano, Claudia, Tribolet, Pascal, Lobo, Dileep N., Gomes, Filomena, Hoess, Claus, Pavlicek, Vojtech, Bilz, Stefan, Sigrist, Sarah, Brändle, Michael, Henzen, Christoph, Thomann, Robert, Rutishauser, Jonas, Aujesky, Drahomir, Rodondi, Nicolas, Donzé, Jacques, Stanga, Zeno, Mueller, Beat, and Schuetz, Philipp

Published
2022
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7. Identification of COVID-19 patients at risk of hospital admission and mortality: a European multicentre retrospective analysis of mid-regional pro-adrenomedullin

Author

Sozio, Emanuela, Moore, Nathan A., Fabris, Martina, Ripoli, Andrea, Rumbolo, Francesca, Minieri, Marilena, Boverio, Riccardo, Rodríguez Mulero, María Dolores, Lainez-Martinez, Sara, Martínez Martínez, Mónica, Calvo, Dolores, Gregoriano, Claudia, Williams, Rebecca, Brazzi, Luca, Terrinoni, Alessandro, Callegari, Tiziana, Hernández Olivo, Marta, Esteban-Torrella, Patricia, Calcerrada, Ismael, Bernasconi, Luca, Kidd, Stephen P., Sbrana, Francesco, Miguens, Iria, Gordon, Kirsty, Visentini, Daniela, Legramante, Jacopo M., Bassi, Flavio, Cortes, Nicholas, Montrucchio, Giorgia, Di Lecce, Vito N., Lauritano, Ernesto C., García de Guadiana-Romualdo, Luis, González del Castillo, Juan, Bernal-Morell, Enrique, Andaluz-Ojeda, David, Schuetz, Philipp, Curcio, Francesco, Tascini, Carlo, and Saeed, Kordo

Published
2022
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16. Predictors for Unplanned Readmissions within 18 Days after Hospital Discharge: a Retrospective Cohort Study

Author

Boesing, Maria, primary, Gregoriano, Claudia, additional, Minder, Anna E., additional, Abshagen, Christian, additional, Dahl, Sylwia, additional, Dieterle, Thomas, additional, Eicher, Frank, additional, Leuppi-Taegtmeyer, Anne B., additional, Rageth, Luana, additional, Miedinger, David, additional, Wirz, Elina, additional, and Leuppi, Joerg D., additional

Published
2023
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18. Association of Interprofessional Discharge Planning Using an Electronic Health Record Tool With Hospital Length of Stay Among Patients with Multimorbidity

Author

Kutz, Alexander, primary, Koch, Daniel, additional, Haubitz, Sebastian, additional, Conca, Antoinette, additional, Baechli, Ciril, additional, Regez, Katharina, additional, Gregoriano, Claudia, additional, Ebrahimi, Fahim, additional, Bassetti, Stefano, additional, Eckstein, Jens, additional, Beer, Juerg, additional, Egloff, Michael, additional, Kaeppeli, Andrea, additional, Ehmann, Tobias, additional, Hoess, Claus, additional, Schaad, Heinz, additional, Wharam, James Frank, additional, Lieberherr, Antoine, additional, Wagner, Ulrich, additional, de Geest, Sabina, additional, Schuetz, Philipp, additional, and Mueller, Beat, additional

Published
2022
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21. Derivation and validation of a prediction model to establish nursing-sensitive quality benchmarks in medical inpatients : a secondary data analysis of a prospective cohort study

Author

Koch, Daniel, Kutz, Alexander, Volken, Thomas, Gregoriano, Claudia, Conca, Antoinette, Kleinknecht-Dolf, Michael, Schuetz, Philipp, Mueller, Beat, Koch, Daniel, Kutz, Alexander, Volken, Thomas, Gregoriano, Claudia, Conca, Antoinette, Kleinknecht-Dolf, Michael, Schuetz, Philipp, and Mueller, Beat

Abstract

Background: Hospitals are using nursing-sensitive outcomes (NSOs) based on administrative data to measure and benchmark quality of nursing care in acute care wards. In order to facilitate comparisons between different hospitals and wards with heterogeneous patient populations, proper adjustment procedures are required. In this article, we first identify predictors for common NSOs in acute medical care of adult patients based on administrative data. We then develop and cross-validate an NSO-oriented prediction model. Methods: We used administrative data from seven hospitals in Switzerland to derive prediction models for each of the following NSO: hospital-acquired pressure ulcer (≥stage II), hospital-acquired urinary tract infection, non-ventilator hospital-acquired pneumonia and in-hospital mortality. We used a split dataset approach by performing a random 80:20 split of the data into a training set and a test set. We assessed discrimination of the models by area under the receiver operating characteristic curves. Finally, we used the validated models to establish a benchmark between the participating hospitals. Results: We considered 36,149 hospitalisations, of which 51.9% were male patients with a median age of 73 years (with an interquartile range of 59–82). Age and length of hospital stay were independently associated with all four NSOs. The derivation and validation models showed a good discrimination in the training (AUC range: 0.75–0.84) and in the test dataset (AUC range:0.77–0.81), respectively. Variation among different hospitals was relevant considering the risk for hospital-acquired pressure ulcer (≥ stage II) (adjusted Odds ratio [aOR] range: 0.51 [95% CI: 0.38–0.69] – 1.65 [95% CI:1.33–2.04]), the risk for hospital-acquired urinary tract infection infection (aOR range: 0.46 [95% CI: 0.36–0.58] – 1.45 [95% CI: 1.31–1.62]), the risk for non-ventilator hospital-acquired pneumonia (aOR range: 0.28 [95% CI: 0.09–0.89] – 2.87 [95% CI: 2.27–3.64]), and the ri

Published
2022

22. Canakinumabin patients with COVID-19 and type 2 diabetes (CanCovDia) - a multicentric, randomised, double-blind, placebo-controlled phase 3 trial

Author

Hepprich, Matthias, primary, Mudry, Jonathan, additional, Gregoriano, Claudia, additional, Jornayvaz, Francois R, additional, Carballo, Sebastian, additional, Wojtusciszyn, Anne, additional, Bart, Pierre-Alexandre, additional, Chiche, Jean-Daniel, additional, Fischli, Stefan, additional, Baumgartner, Thomas, additional, Cavelti-Weder, Claudia, additional, Beuschlein, Felix, additional, Braun, Dominque L, additional, Gunthard, Huldrych F, additional, West, Emily, additional, Conen, Anna, additional, Isenring, Egon, additional, Bucklar, Gabriela, additional, Aubry, Yoann, additional, Dey, Ludovic, additional, Muller, Beat, additional, Schutz, Philipp, additional, Cattaneo, Marco, additional, Hunziker, Patrick, additional, and Donath, Marc Y, additional

Published
2022
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25. Call, chosen, HA2T2, ANDC: validation of four severity scores in COVID-19 patients

Author

Wolfisberg, Selina, primary, Gregoriano, Claudia, additional, Struja, Tristan, additional, Kutz, Alexander, additional, Koch, Daniel, additional, Bernasconi, Luca, additional, Hammerer-Lercher, Angelika, additional, Mohr, Christine, additional, Haubitz, Sebastian, additional, Conen, Anna, additional, Fux, Christoph A., additional, Mueller, Beat, additional, and Schuetz, Philipp, additional

Published
2021
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28. Comparison of characteristics, predictors and outcomes between the first and second COVID-19 waves in a tertiary care centre in Switzerland: an observational analysis

Author

Wolfisberg, Selina, primary, Gregoriano, Claudia, additional, Struja, Tristan, additional, Kutz, Alexander, additional, Koch, Daniel, additional, Bernasconi, Luca, additional, Hammerer-Lercher, Angelika, additional, Mohr, Christine, additional, Haubitz, Sebastian, additional, Conen, Anna, additional, Fux, Christoph A., additional, Mueller, Beat, additional, and Schuetz, Philipp, additional

Published
2021
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30. Duration of antibiotic treatment using procalcitonin-guided treatment algorithms in older patients: a patient-level meta-analysis from randomized controlled trials

Author

Medische Staf Intensive Care, NVIC bedrijfsvoering, Brain, Infection & Immunity, Heilmann, Eva, Gregoriano, Claudia, Annane, Djillali, Reinhart, Konrad, Bouadma, Lila, Wolff, Michel, Chastre, Jean, Luyt, Charles-Edouard, Tubach, Florence, Branche, Angela R, Briel, Matthias, Christ-Crain, Mirjam, Welte, Tobias, Corti, Caspar, de Jong, Evelien, Nijsten, Maarten, de Lange, Dylan W, van Oers, Jos A H, Beishuizen, Albertus, Girbes, Armand R J, Deliberato, Rodrigo O, Schroeder, Stefan, Kristoffersen, Kristina B, Layios, Nathalie, Damas, Pierre, Lima, Stella S S, Nobre, Vandack, Wei, Long, Oliveira, Carolina F, Shehabi, Yahya, Stolz, Daiana, Tamm, Michael, Verduri, Alessia, Wang, Jin-Xiang, Drevet, Sabine, Gavazzi, Gaetan, Mueller, Beat, Schuetz, Philipp, Medische Staf Intensive Care, NVIC bedrijfsvoering, Brain, Infection & Immunity, Heilmann, Eva, Gregoriano, Claudia, Annane, Djillali, Reinhart, Konrad, Bouadma, Lila, Wolff, Michel, Chastre, Jean, Luyt, Charles-Edouard, Tubach, Florence, Branche, Angela R, Briel, Matthias, Christ-Crain, Mirjam, Welte, Tobias, Corti, Caspar, de Jong, Evelien, Nijsten, Maarten, de Lange, Dylan W, van Oers, Jos A H, Beishuizen, Albertus, Girbes, Armand R J, Deliberato, Rodrigo O, Schroeder, Stefan, Kristoffersen, Kristina B, Layios, Nathalie, Damas, Pierre, Lima, Stella S S, Nobre, Vandack, Wei, Long, Oliveira, Carolina F, Shehabi, Yahya, Stolz, Daiana, Tamm, Michael, Verduri, Alessia, Wang, Jin-Xiang, Drevet, Sabine, Gavazzi, Gaetan, Mueller, Beat, and Schuetz, Philipp

Published
2021

32. Duration of antibiotic treatment using procalcitonin-guided treatment algorithms in older patients: a patient-level meta-analysis from randomized controlled trials

Author

Heilmann, Eva, primary, Gregoriano, Claudia, additional, Annane, Djillali, additional, Reinhart, Konrad, additional, Bouadma, Lila, additional, Wolff, Michel, additional, Chastre, Jean, additional, Luyt, Charles-Edouard, additional, Tubach, Florence, additional, Branche, Angela R, additional, Briel, Matthias, additional, Christ-Crain, Mirjam, additional, Welte, Tobias, additional, Corti, Caspar, additional, de Jong, Evelien, additional, Nijsten, Maarten, additional, de Lange, Dylan W, additional, van Oers, Jos A H, additional, Beishuizen, Albertus, additional, Girbes, Armand R J, additional, Deliberato, Rodrigo O, additional, Schroeder, Stefan, additional, Kristoffersen, Kristina B, additional, Layios, Nathalie, additional, Damas, Pierre, additional, Lima, Stella S S, additional, Nobre, Vandack, additional, Wei, Long, additional, Oliveira, Carolina F, additional, Shehabi, Yahya, additional, Stolz, Daiana, additional, Tamm, Michael, additional, Verduri, Alessia, additional, Wang, Jin-Xiang, additional, Drevet, Sabine, additional, Gavazzi, Gaetan, additional, Mueller, Beat, additional, and Schuetz, Philipp, additional

Published
2021
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34. Activation of Vasopressin System During COVID-19 is Associated With Adverse Clinical Outcomes: An Observational Study

Author

Gregoriano, Claudia, primary, Molitor, Alexandra, additional, Haag, Ellen, additional, Kutz, Alexander, additional, Koch, Daniel, additional, Haubitz, Sebastian, additional, Conen, Anna, additional, Bernasconi, Luca, additional, Hammerer-Lercher, Angelika, additional, Fux, Christoph A, additional, Mueller, Beat, additional, and Schuetz, Philipp, additional

Published
2021
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37. Association of kidney function with effectiveness of procalcitonin-guided antibiotic treatment: a patient-level meta-analysis from randomized controlled trials

Author

Heilmann, Eva, primary, Gregoriano, Claudia, additional, Wirz, Yannick, additional, Luyt, Charles-Edouard, additional, Wolff, Michel, additional, Chastre, Jean, additional, Tubach, Florence, additional, Christ-Crain, Mirjam, additional, Bouadma, Lila, additional, Annane, Djillali, additional, Damas, Pierre, additional, Kristoffersen, Kristina B., additional, Oliveira, Carolina F., additional, Stolz, Daiana, additional, Tamm, Michael, additional, de Jong, Evelien, additional, Reinhart, Konrad, additional, Shehabi, Yahya, additional, Verduri, Alessia, additional, Nobre, Vandack, additional, Nijsten, Maarten, additional, deLange, Dylan W., additional, van Oers, Jos A.H., additional, Beishuizen, Albertus, additional, Girbes, Armand R.J., additional, Mueller, Beat, additional, and Schuetz, Philipp, additional

Published
2020
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38. Characteristics, predictors and outcomes among 99 patients hospitalised with COVID-19 in a tertiary care centre in Switzerland: an observational analysis

Author

Gregoriano, Claudia, primary, Koch, Daniel, additional, Haubitz, Sebastian, additional, Conen, Anna, additional, Fux, Christoph A., additional, Mueller, Beat, additional, Bernasconi, Luca, additional, Hammerer-Lercher, Angelika, additional, Oberle, Michael, additional, Burgemeister, Susanne, additional, Reiter, Hartwig, additional, Kutz, Alexander, additional, and Schuetz, Philipp, additional

Published
2020
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40. Call, chosen, HA2T2, ANDC: validation of four severity scores in COVID-19 patients.

Author

Wolfisberg, Selina, Gregoriano, Claudia, Struja, Tristan, Kutz, Alexander, Koch, Daniel, Bernasconi, Luca, Hammerer-Lercher, Angelika, Mohr, Christine, Haubitz, Sebastian, Conen, Anna, Fux, Christoph A., Mueller, Beat, and Schuetz, Philipp

Subjects
COVID-19, SCIENTIFIC observation, RESEARCH methodology evaluation, ACQUISITION of data, RETROSPECTIVE studies, MEDICAL records
Abstract

Purpose: To externally validate four previously developed severity scores (i.e., CALL, CHOSEN, HA2T2 and ANDC) in patients with COVID-19 hospitalised in a tertiary care centre in Switzerland. Methods: This observational analysis included adult patients with a real-time reverse-transcription polymerase chain reaction or rapid-antigen test confirmed severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection hospitalised consecutively at the Cantonal Hospital Aarau from February to December 2020. The primary endpoint was all-cause in-hospital mortality. The secondary endpoint was disease progression, defined as needing invasive ventilation, ICU admission or death. Results: From 399 patients (mean age 66.6 years ± 13.4 SD, 68% males), we had complete data for calculating the CALL, CHOSEN, HA2T2 and ANDC scores in 297, 380, 151 and 124 cases, respectively. Odds ratios for all four scores showed significant associations with mortality. The discriminative power of the HA2T2 score was higher compared to CALL, CHOSEN and ANDC scores [area under the curve (AUC) 0.78 vs. 0.65, 0.69 and 0.66, respectively]. Negative predictive values (NPV) for mortality were high, particularly for the CALL score (≥ 6 points: 100%, ≥ 9 points: 95%). For disease progression, discriminative power was lower, with the CHOSEN score showing the best performance (AUC 0.66). Conclusion: In this external validation study, the four analysed scores had a lower performance compared to the original cohorts regarding prediction of mortality and disease progression. However, all scores were significantly associated with mortality and the NPV of the CALL and CHOSEN scores in particular allowed reliable identification of patients at low risk, making them suitable for outpatient management. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Procalcitonin for individualizing antibiotic treatment: an update with a focus on COVID-19.

Author

Wolfisberg, Selina, Gregoriano, Claudia, and Schuetz, Philipp

Subjects
*ANTIMICROBIAL stewardship, *BIOMARKERS, *COVID-19, *CALCITONIN, *ANTI-infective agents, *RESPIRATORY infections, *VIRUS diseases, *BACTERIAL diseases, *DRUG resistance in microorganisms, *ANTIBIOTICS
Abstract

Procalcitonin (PCT) is useful for differentiating between viral and bacterial infections and for reducing the unnecessary use of antibiotics. As the rise of antimicrobial resistance reaches "alarming" levels according to the World Health Organization, the importance of using biomarkers, such as PCT to limit unnecessary antibiotic exposure has further increased. Randomized trials in patients with respiratory tract infections have shown that PCT has prognostic implications and its use, embedded in stewardship protocols, leads to reductions in the use of antibiotics in different clinical settings without compromising clinical outcomes. However, available data are heterogeneous and recent trials found no significant benefit. Still, from these trials, we have learned several key considerations for the optimal use of PCT, which depend on the clinical setting, severity of presentation, and pretest probability for bacterial infection. For patients with respiratory infections and sepsis, PCT can be used to determine whether to initiate antimicrobial therapy in low-risk settings and, together with clinical data, whether to discontinue antimicrobial therapy in certain high-risk settings. There is also increasing evidence regarding PCT-guided therapy in patients with coronavirus disease 2019 (COVID-19). This review provides an up-to-date overview of the use of PCT in different clinical settings and diseases, including a discussion about its potential to improve the care of patients with COVID-19. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Impact of Targeted Hyponatremia Correction on 30-Day Mortality and Rehospitalization Rate

Author

Refardt, Julie, Potasso, Laura, Pelouto, Anissa, Gregoriano, Claudia, Koster, Markus, Vodanovic, Ivana Dora, Norello, Dario, Ravioli, Svenja, Cukoski, Sadrija, Sambula, Lana, Rapsch, Nikola, Monnerat, Sophie, Beck, Julia, Vogt, Deborah R., Bontognali, Martina Luisa, Schuetz, Philipp, Zandbergen, Adrienne Anne Marie, Peri, Alessandro, Kastelan, Darko, Lindner, Gregor, Leuppi, Jörg Daniel, Mueller, Beat, Burst, Volker Rolf, Hoorn, Ewout J., and Christ-Crain, Mirjam

Published
2024
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43. MOESM1 of Does a tailored intervention to promote adherence in patients with chronic lung disease affect exacerbations? A randomized controlled trial

Author

Gregoriano, Claudia, Dieterle, Thomas, Anna-Lisa Breitenstein, Dürr, Selina, Baum, Amanda, Giezendanner, Stéphanie, Maier, Sabrina, Leuppi-Taegtmeyer, Anne, Arnet, Isabelle, Hersberger, Kurt, and Leuppi, Jörg

Abstract

Additional file 1. Visualization graph for SmartinhalerTM and Polymedication Electronic Monitoring System.

Published
2019
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47. Does a Tailored Intervention to Promote Adherence in Patients with Chronic Lung Disease Affect Exacerbations?

Author

Gregoriano, Claudia, primary, Dieterle, Thomas, additional, Breitenstein, Anna-Lisa, additional, Dürr, Selina, additional, Baum, Amanda, additional, Giezendanner, Stéphanie, additional, Maier, Sabrina, additional, Leuppi-Taegtmeyer, Anne, additional, Arnet, Isabelle, additional, Hersberger, Kurt E., additional, and Leuppi, Jörg D., additional

Published
2019
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50. Cardiovascular risk stratification in primary care patients with arterial hypertension: Results from the Swiss Hypertension Cohort Study (HccH)

Author

Handschin, Anja, primary, Brighenti-Zogg, Stefanie, additional, Mundwiler, Jonas, additional, Giezendanner, Stéphanie, additional, Gregoriano, Claudia, additional, Martina, Benedict, additional, Tschudi, Peter, additional, Leuppi, Jörg D, additional, Zeller, Andreas, additional, and Dieterle, Thomas, additional

Published
2019
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