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26 results on '"Greenstein, Erez"'

1. Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma

Author

Rosenberg, Miriam I., Greenstein, Erez, Buchkovich, Martin, Peres, Ayelet, Santoni-Rugiu, Eric, Yang, Lei, Mikl, Martin, Vaksman, Zalman, Gibbs, David L., Reshef, Dan, Salovin, Amy, Irwin, Meredith S., Naranjo, Arlene, Ulitsky, Igor, de Alarcon, Pedro A., Matthay, Katherine K., Weigman, Victor, Yaari, Gur, Panzer, Jessica A., Friedman, Nir, and Maris, John M.

Published
2023
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2. Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection

Author

Milighetti, Martina, Peng, Yanchun, Tan, Cedric, Mark, Michal, Nageswaran, Gayathri, Byrne, Suzanne, Ronel, Tahel, Peacock, Tom, Mayer, Andreas, Chandran, Aneesh, Rosenheim, Joshua, Whelan, Matthew, Yao, Xuan, Liu, Guihai, Felce, Suet Ling, Dong, Tao, Mentzer, Alexander J., Knight, Julian C., Balloux, Francois, Greenstein, Erez, Reich-Zeliger, Shlomit, Pade, Corinna, Gibbons, Joseph M., Semper, Amanda, Brooks, Tim, Otter, Ashley, Altmann, Daniel M., Boyton, Rosemary J., Maini, Mala K., McKnight, Aine, Manisty, Charlotte, Treibel, Thomas A., Moon, James C., Noursadeghi, Mahdad, and Chain, Benny

Published
2023
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3. Combined presentation and immunogenicity analysis reveals a recurrent RAS.Q61K neoantigen in melanoma

Author

Peri, Aviyah, Greenstein, Erez, Alon, Michal, Pai, Joy A., Dingjan, Tamir, Reich- Zeliger, Shlomit, Barnea, Eilon, Barbolin, Chaya, Levy, Ronen, Arnedo-Pac, Claudia, Kalaora, Shelly, Dassa, Bareket, Feldmesser, Ester, Shang, Ping, Greenberg, Polina, Levin, Yishai, Benedek, Gil, Levesque, Mitchell P., Adams, David J., Lotem, Michal, Wilmott, James S., Scolyer, Richard A., Jonsson, Goran B., Admon, Arie, Rosenberg, Steven A., Cohen, Cyrille J., Niv, Masha Y., Lopez- Bigas, Nuria, Satpathy, Ansuman T., Friedman, Nir, and Samuels, Yardena

Subjects
HLA histocompatibility antigens -- Identification and classification -- Genetic aspects, Immune response -- Genetic aspects, Tumor antigens -- Genetic aspects -- Identification and classification, Melanoma -- Diagnosis -- Genetic aspects, Histocompatibility antigens -- Identification and classification -- Genetic aspects, Guanosine triphosphatase -- Genetic aspects -- Health aspects, Health care industry
Abstract

Neoantigens are now recognized drivers of the antitumor immune response. Recurrent neoantigens, shared among groups of patients, have thus become increasingly coveted therapeutic targets. Here, we report on the data-driven identification of a robustly presented, immunogenic neoantigen that is derived from the combination of HLA-A*01:01 and RAS.Q61K. Analysis of large patient cohorts indicated that this combination applies to 3% of patients with melanoma. Using HLA peptidomics, we were able to demonstrate robust endogenous presentation of the neoantigen in 10 tumor samples. We detected specific reactivity to the mutated peptide within tumor-infiltrating lymphocytes (TILs) from 2 unrelated patients, thus confirming its natural immunogenicity. We further investigated the neoantigen-specific clones and their T cell receptors (TCRs) via a combination of TCR sequencing, TCR overexpression, functional assays, and single-cell transcriptomics. Our analysis revealed a diverse repertoire of neoantigen-specific clones with both intra- and interpatient TCR similarities. Moreover, 1 dominant clone proved to cross-react with the highly prevalent RAS.Q61R variant. Transcriptome analysis revealed a high association of TCR clones with specific T cell phenotypes in response to cognate melanoma, with neoantigen-specific cells showing an activated and dysfunctional phenotype. Identification of recurrent neoantigens and their reactive TCRs can promote 'off-the-shelf' precision immunotherapies, alleviating limitations of personalized treatments., Introduction Immunotherapy sparked new hope for oncology in recent years, due to its remarkable ability to induce long-term tumor regression of metastatic cancer. This feature is shared across immunotherapeutic modalities, [...]

Published
2021
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5. Supplementary Movies 7-9 from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, primary, Feferman, Tali, primary, Barnea, Eilon, primary, Greenstein, Erez, primary, Reshef, Dan, primary, Tirosh, Itay, primary, Reuben, Alexandre, primary, Patkar, Sushant, primary, Levy, Ronen, primary, Quinkhardt, Juliane, primary, Omokoko, Tana, primary, Qutob, Nouar, primary, Golani, Ofra, primary, Zhang, Jianhua, primary, Mao, Xizeng, primary, Song, Xingzhi, primary, Bernatchez, Chantale, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Creasy, Caitlin, primary, Greenberg, Polina, primary, Carter, Brett W., primary, Cooper, Zachary A., primary, Rosenberg, Steven A., primary, Lotem, Michal, primary, Sahin, Ugur, primary, Shakhar, Guy, primary, Ruppin, Eytan, primary, Wargo, Jennifer A., primary, Friedman, Nir, primary, Admon, Arie, primary, and Samuels, Yardena, primary

Published
2023
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6. Supplementary Movies 4-6 from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, primary, Feferman, Tali, primary, Barnea, Eilon, primary, Greenstein, Erez, primary, Reshef, Dan, primary, Tirosh, Itay, primary, Reuben, Alexandre, primary, Patkar, Sushant, primary, Levy, Ronen, primary, Quinkhardt, Juliane, primary, Omokoko, Tana, primary, Qutob, Nouar, primary, Golani, Ofra, primary, Zhang, Jianhua, primary, Mao, Xizeng, primary, Song, Xingzhi, primary, Bernatchez, Chantale, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Creasy, Caitlin, primary, Greenberg, Polina, primary, Carter, Brett W., primary, Cooper, Zachary A., primary, Rosenberg, Steven A., primary, Lotem, Michal, primary, Sahin, Ugur, primary, Shakhar, Guy, primary, Ruppin, Eytan, primary, Wargo, Jennifer A., primary, Friedman, Nir, primary, Admon, Arie, primary, and Samuels, Yardena, primary

Published
2023
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7. Data from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, primary, Feferman, Tali, primary, Barnea, Eilon, primary, Greenstein, Erez, primary, Reshef, Dan, primary, Tirosh, Itay, primary, Reuben, Alexandre, primary, Patkar, Sushant, primary, Levy, Ronen, primary, Quinkhardt, Juliane, primary, Omokoko, Tana, primary, Qutob, Nouar, primary, Golani, Ofra, primary, Zhang, Jianhua, primary, Mao, Xizeng, primary, Song, Xingzhi, primary, Bernatchez, Chantale, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Creasy, Caitlin, primary, Greenberg, Polina, primary, Carter, Brett W., primary, Cooper, Zachary A., primary, Rosenberg, Steven A., primary, Lotem, Michal, primary, Sahin, Ugur, primary, Shakhar, Guy, primary, Ruppin, Eytan, primary, Wargo, Jennifer A., primary, Friedman, Nir, primary, Admon, Arie, primary, and Samuels, Yardena, primary

Published
2023
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8. Supplementary Movies 1-3 from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, primary, Feferman, Tali, primary, Barnea, Eilon, primary, Greenstein, Erez, primary, Reshef, Dan, primary, Tirosh, Itay, primary, Reuben, Alexandre, primary, Patkar, Sushant, primary, Levy, Ronen, primary, Quinkhardt, Juliane, primary, Omokoko, Tana, primary, Qutob, Nouar, primary, Golani, Ofra, primary, Zhang, Jianhua, primary, Mao, Xizeng, primary, Song, Xingzhi, primary, Bernatchez, Chantale, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Creasy, Caitlin, primary, Greenberg, Polina, primary, Carter, Brett W., primary, Cooper, Zachary A., primary, Rosenberg, Steven A., primary, Lotem, Michal, primary, Sahin, Ugur, primary, Shakhar, Guy, primary, Ruppin, Eytan, primary, Wargo, Jennifer A., primary, Friedman, Nir, primary, Admon, Arie, primary, and Samuels, Yardena, primary

Published
2023
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9. Supplementary methods from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, primary, Feferman, Tali, primary, Barnea, Eilon, primary, Greenstein, Erez, primary, Reshef, Dan, primary, Tirosh, Itay, primary, Reuben, Alexandre, primary, Patkar, Sushant, primary, Levy, Ronen, primary, Quinkhardt, Juliane, primary, Omokoko, Tana, primary, Qutob, Nouar, primary, Golani, Ofra, primary, Zhang, Jianhua, primary, Mao, Xizeng, primary, Song, Xingzhi, primary, Bernatchez, Chantale, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Creasy, Caitlin, primary, Greenberg, Polina, primary, Carter, Brett W., primary, Cooper, Zachary A., primary, Rosenberg, Steven A., primary, Lotem, Michal, primary, Sahin, Ugur, primary, Shakhar, Guy, primary, Ruppin, Eytan, primary, Wargo, Jennifer A., primary, Friedman, Nir, primary, Admon, Arie, primary, and Samuels, Yardena, primary

Published
2023
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10. Supplementary Tables 1, 2, 4, 5, 8, 10, 13, 14, 15 from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, primary, Feferman, Tali, primary, Barnea, Eilon, primary, Greenstein, Erez, primary, Reshef, Dan, primary, Tirosh, Itay, primary, Reuben, Alexandre, primary, Patkar, Sushant, primary, Levy, Ronen, primary, Quinkhardt, Juliane, primary, Omokoko, Tana, primary, Qutob, Nouar, primary, Golani, Ofra, primary, Zhang, Jianhua, primary, Mao, Xizeng, primary, Song, Xingzhi, primary, Bernatchez, Chantale, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Creasy, Caitlin, primary, Greenberg, Polina, primary, Carter, Brett W., primary, Cooper, Zachary A., primary, Rosenberg, Steven A., primary, Lotem, Michal, primary, Sahin, Ugur, primary, Shakhar, Guy, primary, Ruppin, Eytan, primary, Wargo, Jennifer A., primary, Friedman, Nir, primary, Admon, Arie, primary, and Samuels, Yardena, primary

Published
2023
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11. Supplementary Tables 3, 6, 7, 9, 11, 12 from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, primary, Feferman, Tali, primary, Barnea, Eilon, primary, Greenstein, Erez, primary, Reshef, Dan, primary, Tirosh, Itay, primary, Reuben, Alexandre, primary, Patkar, Sushant, primary, Levy, Ronen, primary, Quinkhardt, Juliane, primary, Omokoko, Tana, primary, Qutob, Nouar, primary, Golani, Ofra, primary, Zhang, Jianhua, primary, Mao, Xizeng, primary, Song, Xingzhi, primary, Bernatchez, Chantale, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Creasy, Caitlin, primary, Greenberg, Polina, primary, Carter, Brett W., primary, Cooper, Zachary A., primary, Rosenberg, Steven A., primary, Lotem, Michal, primary, Sahin, Ugur, primary, Shakhar, Guy, primary, Ruppin, Eytan, primary, Wargo, Jennifer A., primary, Friedman, Nir, primary, Admon, Arie, primary, and Samuels, Yardena, primary

Published
2023
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12. Supplementary Figures 1-17 from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, primary, Feferman, Tali, primary, Barnea, Eilon, primary, Greenstein, Erez, primary, Reshef, Dan, primary, Tirosh, Itay, primary, Reuben, Alexandre, primary, Patkar, Sushant, primary, Levy, Ronen, primary, Quinkhardt, Juliane, primary, Omokoko, Tana, primary, Qutob, Nouar, primary, Golani, Ofra, primary, Zhang, Jianhua, primary, Mao, Xizeng, primary, Song, Xingzhi, primary, Bernatchez, Chantale, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Creasy, Caitlin, primary, Greenberg, Polina, primary, Carter, Brett W., primary, Cooper, Zachary A., primary, Rosenberg, Steven A., primary, Lotem, Michal, primary, Sahin, Ugur, primary, Shakhar, Guy, primary, Ruppin, Eytan, primary, Wargo, Jennifer A., primary, Friedman, Nir, primary, Admon, Arie, primary, and Samuels, Yardena, primary

Published
2023
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14. Large Clones of Pre-Existing T Cells Drive Early Immunity Against SARS-COV-2 and LCMV Infection

Author

Milighetti, Martina, primary, Peng, Yanchun, additional, Tan, Cedric, additional, Mark, Michal, additional, Nageswaran, Gayathri, additional, Byrne, Suzanne, additional, Ronel, Tahel, additional, Peacock, Tom, additional, Mayer, Andreas, additional, Chandran, Aneesh, additional, Rosenheim, Joshua, additional, Whelan, Matthew V.X., additional, Yao, Xuan, additional, Liu, Guihai, additional, Felce, Suet Ling, additional, Dong, Tao, additional, Mentzer, Alexander J., additional, Knight, Julian, additional, Balloux, François, additional, Greenstein, Erez, additional, Reich-Zeliger, Shlomit, additional, Pade, Corinna, additional, Gibbons, Joseph, additional, Semper, Amanda, additional, Brooks, Tim, additional, Otter, Ashley, additional, Altmann, Daniel M., additional, Boyton, Rosemary J., additional, Maini, Mala K., additional, McKnight, Aine, additional, Manisty, Charlotte, additional, Treibel, Thomas A., additional, Moon, James C., additional, Investigators, COVIDsortium, additional, Noursadeghi, Mahdad, additional, and Chain, Benny, additional

Published
2023
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18. Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma

Author

Rosenberg, Miriam I, primary, Greenstein, Erez, additional, Buchkovich, Martin, additional, Mikl, Martin, additional, Peres, Ayelet, additional, Santoni-Rugiu, Eric, additional, Reshef, Dan, additional, Salovin, Amy J, additional, Gibbs, David L, additional, Irwin, Meredith S, additional, Naranjo, Arlene, additional, Ulitsky, Igor, additional, de Alarcon, Pedro A, additional, Weigman, Victor, additional, Yaari, Gur, additional, Panzer, Jessica A, additional, Friedman, Nir, additional, and Maris, John M, additional

Published
2021
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21. The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer

Author

De Mattos-Arruda, Leticia, primary, Sammut, Stephen-John, additional, Ross, Edith M., additional, Bashford-Rogers, Rachael, additional, Greenstein, Erez, additional, Markus, Havell, additional, Morganella, Sandro, additional, Teng, Yvonne, additional, Maruvka, Yosef, additional, Pereira, Bernard, additional, Rueda, Oscar M., additional, Chin, Suet-Feung, additional, Contente-Cuomo, Tania, additional, Mayor, Regina, additional, Arias, Alexandra, additional, Ali, H. Raza, additional, Cope, Wei, additional, Tiezzi, Daniel, additional, Dariush, Aliakbar, additional, Dias Amarante, Tauanne, additional, Reshef, Dan, additional, Ciriaco, Nikaoly, additional, Martinez-Saez, Elena, additional, Peg, Vicente, additional, Ramon y Cajal, Santiago, additional, Cortes, Javier, additional, Vassiliou, George, additional, Getz, Gad, additional, Nik-Zainal, Serena, additional, Murtaza, Muhammed, additional, Friedman, Nir, additional, Markowetz, Florian, additional, Seoane, Joan, additional, and Caldas, Carlos, additional

Published
2019
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22. Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, additional, Feferman, Tali, additional, Barnea, Eilon, additional, Greenstein, Erez, additional, Reshef, Dan, additional, Tirosh, Itay, additional, Reuben, Alexandre, additional, Patkar, Sushant, additional, Levy, Ronen, additional, Quinkhardt, Juliane, additional, Omokoko, Tana, additional, Qutob, Nouar, additional, Golani, Ofra, additional, Zhang, Jianhua, additional, Mao, Xizeng, additional, Song, Xingzhi, additional, Bernatchez, Chantale, additional, Haymaker, Cara, additional, Forget, Marie-Andrée, additional, Creasy, Caitlin, additional, Greenberg, Polina, additional, Carter, Brett W., additional, Cooper, Zachary A., additional, Rosenberg, Steven A., additional, Lotem, Michal, additional, Sahin, Ugur, additional, Shakhar, Guy, additional, Ruppin, Eytan, additional, Wargo, Jennifer A., additional, Friedman, Nir, additional, Admon, Arie, additional, and Samuels, Yardena, additional

Published
2018
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23. The integrated genomic and immune landscapes of lethal metastatic breast cancer (MBC).

Author

De Mattos-Arruda, Leticia, primary, Sammut, Stephen-John, additional, Ross, Edith M, additional, Bashford-Rogers, Rachael, additional, Greenstein, Erez, additional, Morganella, Sandro, additional, Rueda, Oscar M, additional, Martinez-Saez, Elena, additional, Peg, Vicente, additional, Cortés, Javier, additional, Nik-Zainal, Serena, additional, Murtaza, Muhammed, additional, Friedman, Nir, additional, Markowetz, Florian, additional, Seoane, Joan, additional, and Caldas, Carlos, additional

Published
2018
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24. T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences

Author

Madi, Asaf, primary, Poran, Asaf, additional, Shifrut, Eric, additional, Reich-Zeliger, Shlomit, additional, Greenstein, Erez, additional, Zaretsky, Irena, additional, Arnon, Tomer, additional, Laethem, Francois Van, additional, Singer, Alfred, additional, Lu, Jinghua, additional, Sun, Peter D, additional, Cohen, Irun R, additional, and Friedman, Nir, additional

Published
2017
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25. Author response: T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences

Author

Madi, Asaf, primary, Poran, Asaf, additional, Shifrut, Eric, additional, Reich-Zeliger, Shlomit, additional, Greenstein, Erez, additional, Zaretsky, Irena, additional, Arnon, Tomer, additional, Laethem, Francois Van, additional, Singer, Alfred, additional, Lu, Jinghua, additional, Sun, Peter D, additional, Cohen, Irun R, additional, and Friedman, Nir, additional

Published
2017
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26. The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer

Author

De Mattos-Arruda, Leticia, Sammut, Stephen-John, Ross, Edith M, Bashford-Rogers, Rachael, Greenstein, Erez, Markus, Havell, Morganella, Sandro, Teng, Yvonne, Maruvka, Yosef, Pereira, Bernard, Rueda, Oscar M, Chin, Suet-Feung, Contente-Cuomo, Tania, Mayor, Regina, Arias, Alexandra, Ali, H Raza, Cope, Wei, Tiezzi, Daniel, Dariush, Aliakbar, Dias Amarante, Tauanne, Reshef, Dan, Ciriaco, Nikaoly, Martinez-Saez, Elena, Peg, Vicente, Ramon Y Cajal, Santiago, Cortes, Javier, Vassiliou, George, Getz, Gad, Nik-Zainal, Serena, Murtaza, Muhammed, Friedman, Nir, Markowetz, Florian, Seoane, Joan, and Caldas, Carlos

Subjects
metastatic phylogenies, Gene Expression Profiling, Loss of Heterozygosity, genomic landscapes, Breast Neoplasms, Genomics, stem mutations, 3. Good health, immunoediting, Gene Expression Regulation, Neoplastic, TCR repertoire, private mutations, breast cancer, Mutation, Exome Sequencing, Biomarkers, Tumor, Tumor Microenvironment, Humans, Female, Neoplasm Metastasis, metastases, clade mutations, immune landscapes
Abstract

The detailed molecular characterization of lethal cancers is a prerequisite to understanding resistance to therapy and escape from cancer immunoediting. We performed extensive multi-platform profiling of multi-regional metastases in autopsies from 10 patients with therapy-resistant breast cancer. The integrated genomic and immune landscapes show that metastases propagate and evolve as communities of clones, reveal their predicted neo-antigen landscapes, and show that they can accumulate HLA loss of heterozygosity (LOH). The data further identify variable tumor microenvironments and reveal, through analyses of T cell receptor repertoires, that adaptive immune responses appear to co-evolve with the metastatic genomes. These findings reveal in fine detail the landscapes of lethal metastatic breast cancer.

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