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114 results on '"Greenebaum, Ellen"'

1. Radiation Dose Does Not Affect the Predictive Value of Thyroid Biopsy for Diagnosing Papillary Thyroid Cancer in a Belarusian Cohort Exposed to Chernobyl Fallout

Author

McConnell, Robert J., primary, Kamysh, Olga, additional, O'Kane, Patrick L., additional, Greenebaum, Ellen, additional, Rozhko, Alexander V., additional, Yauseyenka, Vasilina V., additional, Minenko, Victor F., additional, Drozdovitch, Vladimir, additional, Yarets, Yuliya, additional, Kukhta, Tatiana, additional, Mabuchi, Kiyohiko, additional, Little, Mark P., additional, Cahoon, Elizabeth K., additional, and Zablotska, Lydia B., additional

Published
2024
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2. I-131 Dose Response for Incident Thyroid Cancers in Ukraine Related to the Chornobyl Accident

Author

Brenner, Alina V, Tronko, Mykola D, Hatch, Maureen, Bogdanova, Tetyana I, Oliynik, Valery A, Lubin, Jay H, Zablotska, Lydia B, Tereschenko, Valery P, McConnell, Robert J, Zamotaeva, Galina A, O’Kane, Patrick, Bouville, Andre C, Chaykovskaya, Ludmila V, Greenebaum, Ellen, Paster, Ihor P, Shpak, Victor M, and Ron, Elaine

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Prevention, Cancer, 2.2 Factors relating to the physical environment, Aetiology, Adolescent, Adult, Chernobyl Nuclear Accident, Cohort Studies, Dose-Response Relationship, Radiation, Female, Humans, Iodide Peroxidase, Iodine Radioisotopes, Male, Middle Aged, Neoplasms, Radiation-Induced, Poisson Distribution, Prospective Studies, Radioactive Hazard Release, Thyroglobulin, Thyroid Diseases, Thyroid Gland, Thyroid Neoplasms, Thyrotropin, Time Factors, Ukraine, Young Adult, Chernobyl nuclear accident, Chornobyl, 1986, dose-response relationship, incidence, thyroid neoplasms/epidemiology, iodine, radioactive, radiation, Environmental Sciences, Medical and Health Sciences, Toxicology, Biomedical and clinical sciences, Environmental sciences, Health sciences
Abstract

BackgroundCurrent knowledge about Chornobyl-related thyroid cancer risks comes from ecological studies based on grouped doses, case-control studies, and studies of prevalent cancers.ObjectiveTo address this limitation, we evaluated the dose-response relationship for incident thyroid cancers using measurement-based individual iodine-131 (I-131) thyroid dose estimates in a prospective analytic cohort study.MethodsThe cohort consists of individuals < 18 years of age on 26 April 1986 who resided in three contaminated oblasts (states) of Ukraine and underwent up to four thyroid screening examinations between 1998 and 2007 (n = 12,514). Thyroid doses of I-131 were estimated based on individual radioactivity measurements taken within 2 months after the accident, environmental transport models, and interview data. Excess radiation risks were estimated using Poisson regression models.ResultsSixty-five incident thyroid cancers were diagnosed during the second through fourth screenings and 73,004 person-years (PY) of observation. The dose-response relationship was consistent with linearity on relative and absolute scales, although the excess relative risk (ERR) model described data better than did the excess absolute risk (EAR) model. The ERR per gray was 1.91 [95% confidence interval (CI), 0.43-6.34], and the EAR per 10⁴ PY/Gy was 2.21 (95% CI, 0.04-5.78). The ERR per gray varied significantly by oblast of residence but not by time since exposure, use of iodine prophylaxis, iodine status, sex, age, or tumor size.ConclusionsI-131-related thyroid cancer risks persisted for two decades after exposure, with no evidence of decrease during the observation period. The radiation risks, although smaller, are compatible with those of retrospective and ecological post-Chornobyl studies.

Published
2011

3. A Cohort Study of Thyroid Cancer and Other Thyroid Diseases after the Chornobyl Accident: Objectives, Design and Methods

Author

Stezhko, Valentin A., Buglova, Elena E., Danilova, Larissa I., Drozd, Valentina M., Krysenko, Nikolaj A., Lesnikova, Nadia R., Minenko, Victor F., Ostapenko, Vladislav A., Petrenko, Sergey V., Polyanskaya, Olga N., Rzheutski, Valery A., Tronko, Mykola D., Bobylyova, Olga O., Bogdanova, Tetyana I., Ephstein, Ovsiy V., Kairo, Iryna A., Kostin, Olexander V., Likhtarev, Ilya A., Markov, Valentin V., Oliynik, Valery A., Shpak, Viktor M., Tereshchenko, Valerity P., Zamotayeva, Galina A., Beebe, Gilbert W., Bouville, Andre C., Brill, Aaron B., Burch, John D., Fink, Daniel J., Greenebaum, Ellen, Howe, Geoffrey R., Luckyanov, Nickolas K., Masnyk, Ihor J., McConnell, Robert J., Robbins, Jacob, Thomas, Terry L., Voillequé, Paul G., and Zablotska, Lydia B.

Published
2004

5. NA cohort study of thyroid cancer and other thyroid diseases after the Chernobyl accident: cytohistopathologic correlation and accuracy of fine-needle aspiration biopsy in nodules detected during the first screening in Ukraine (1998-2000)

Author

Bozhok, Yurly, Greenebaum, Ellen, Bogdanova, Tetyana, McConnell, Robert J., Zelinskaya, Anna, Brenner, Alina V., Zurnadzhy, Lyudmyla Y., Zablotska, Lydia, Tronko, Mykola D., and Hatch, Maureen

Subjects
Chernobyl, Ukraine, Nuclear Accident, 1986, Thyroid cancer -- Diagnosis, Thyroid cancer -- Research, Thyroid cancer -- Demographic aspects, Thyroid cancer -- Risk factors, Biopsy, Needle -- Usage, Biopsy, Needle -- Research, Cohort analysis -- Reports, Cancer -- Diagnosis, Cancer -- Reports, Health
Published
2009

7. A Cohort Study of Thyroid Cancer and Other Thyroid Diseases after the Chornobyl Accident: Dose-Response Analysis of Thyroid Follicular Adenomas Detected during First Screening in Ukraine (1998–2000)

Author

Zablotska, Lydia B., Bogdanova, Tetyana I., Ron, Elaine, Epstein, Ovsiy V., Robbins, Jacob, Likhtarev, Illya A., Hatch, Maureen, Markov, Valentyn V., Bouville, Andre C., Olijnyk, Valery A., McConnell, Robert J., Shpak, Victor M., Brenner, Alina, Terekhova, Galina N., Greenebaum, Ellen, Tereshchenko, Valery P., Fink, Daniel J., Brill, Aaron B., Zamotayeva, Galina A., Masnyk, Ihor J., Howe, Geoffrey R., and Tronko, Mykola D.

Published
2008

12. A Cohort Study of Thyroid Cancer and Other Thyroid Diseases After the Chornobyl Accident: Thyroid Cancer in Ukraine Detected During First Screening

Author

Tronko, Mykola D., Howe, Geoffrey R., Bogdanova, Tetyana I., Bouville, Andre C., Epstein, Ovsiy V., Brill, Aaron B., Likhtarev, Illya A., Fink, Daniel J., Markov, Valentyn V., Greenebaum, Ellen, Olijnyk, Valery A., Masnyk, Ihor J., Shpak, Victor M., McConnell, Robert J., Tereshchenko, Valery P., Robbins, Jacob, Zvinchuk, Oleksandr V., Zablotska, Lydia B., Hatch, Maureen, Luckyanov, Nickolas K., Ron, Elaine, Thomas, Terry L., Voillequé, Paul G., and Beebe, Gilbert W.

Published
2006

21. Differences in Sonographic Conspicuity According to Papillary Thyroid Cancer Subtype: Results of the Ukrainian–American Cohort Study After the Chornobyl Accident

Author

O'Kane, Patrick, primary, Shelkovoy, Evgeniy, additional, McConnell, Robert J., additional, Shpak, Victor, additional, Parker, Laurence, additional, Bogdanova, Tatiana I., additional, Brenner, Alina, additional, Naida, Yuri, additional, Frangos, Andrea, additional, Zablotska, Lydia, additional, Robbins, Jacob, additional, Greenebaum, Ellen, additional, Zurnadzhy, Lydia Y., additional, Tronko, Mykolo, additional, and Hatch, Maureen, additional

Published
2008
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23. Thyroid gland and radiation (Ukrainian-American Thyroid Project)

Author

Tronko, Mykola D., primary, Bobylyova, Olga O., additional, Bogdanova, Tetyana I., additional, Epshtein, Ovsiy V., additional, Likhtaryov, Illya A., additional, Markov, Valentyn V., additional, Oliynyk, Valery A., additional, Tereshchenko, Valery P., additional, Shpak, Viktor M., additional, Beebe, Gilbert, additional, Bouville, André, additional, Brill, Aaron, additional, Burch, David, additional, Fink, Daniel, additional, Greenebaum, Ellen, additional, Howe, Geoffrey, additional, Luckyanov, Nicholas, additional, Masnyk, Ihor, additional, McConnell, Robert, additional, Robbins, Jacob, additional, Thomas, Terry, additional, and Voillequé, Paul, additional

Published
2003
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40. Isolated sigmoid tuberculosis

Author

Horvath, Karen D., primary, Whelan, Richard L., additional, Weinstein, Samuel, additional, Basner, Adam L., additional, Staugaitis, Susan M., additional, and Greenebaum, Ellen, additional

Published
1995
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45. NA cohort study of thyroid cancer and other thyroid diseases after the Chernobyl accident: cytohistopathologic correlation and accuracy of fine-needle aspiration biopsy in nodules detected during the first screening in Ukraine (1998-2000).

Author

Bozhok Y, Greenebaum E, Bogdanova TI, McConnell RJ, Zelinskaya A, Brenner AV, Zurnadzhy LY, Zablotska L, Tronko MD, Hatch M, Bozhok, Yuriy, Greenebaum, Ellen, Bogdanova, Tetyana I, McConnell, Robert J, Zelinskaya, Anna, Brenner, Alina V, Zurnadzhy, Lyudmyla Y, Zablotska, Lydia, Tronko, Mykola D, and Hatch, Maureen

Abstract

Background: The Ukrainian American Cohort Study was established to evaluate the risk of thyroid disorders in a group exposed as children and adolescents to 131I by the Chernobyl accident (arithmetic mean thyroid dose, 0.79 grays). Individuals are screened by palpation and ultrasound and are referred to surgery according to fine-needle aspiration biopsy (FNA). However, the accuracy of FNA cytology for detecting histopathologically confirmed malignancy after this level of internal exposure to radioiodines is unknown.Methods: During the first screening cycle (1998-2000), 13,243 individuals were examined, 356 individuals with thyroid nodules were referred for FNA, 288 individuals completed the procedure, 85 individuals were referred to surgery, 82 individuals underwent surgery, and preoperative cytology was available for review in 78 individuals. Cytologic interpretation for the nodule that resulted in surgical referral was correlated with final pathomorphology; discrepancies were reviewed retrospectively; and the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of FNA cytology were calculated.Results: All 24 cytologic interpretations that were definite for papillary thyroid cancer (PTC) were confirmed histopathologically (PPV, 100%); and, of 11 cytologic interpretations that were suspicious for PTC, 10 were confirmed (PPV, 90.9%). Ten of 41 FNAs that were interpreted as either definite or suspect for follicular neoplasm were confirmed as malignant (PPV, 24.4%), including 2 follicular thyroid cancers and 8 PTCs (all but 1 of the follicular or mixed subtypes). Depending on whether a cytologic interpretation of follicular neoplasm was considered "positive" or "negative," the sensitivity was 100% and 77.3%, respectively; similarly, the respective specificity was 17.6% and 97.1%, the respective PPV was 61.1% and 97.1%, and the respective NPV was 100% and 76.7%.Conclusions: Among children and adolescents who were exposed to 131I after the Chernobyl accident and were evaluated 12 to 14 years later, thyroid cytology had a sensitivity and a predictive value similar to those reported in unexposed populations. [ABSTRACT FROM AUTHOR]

Published
2011
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49. A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accidentThis article is a US Government work and, as such, is in the public domain in the United States of America.: Pathology analysis of thyroid cancer cases in Ukraine detected during the first screening (1998‐2000)

Author

Bogdanova, Tetyana I., Zurnadzhy, Ludmyla Y., Greenebaum, Ellen, McConnell, Robert J., Robbins, Jacob, Epstein, Ovsiy V., Olijnyk, Valery A., Hatch, Maureen, Zablotska, Lydia B., and Tronko, Mykola D.

Abstract

The Ukrainian American Cohort Study evaluated the risk of thyroid disorders in a group of individuals who were younger than age 18 years at the time of the Chornobyl (Chernobyl) accident. In this article, the authors describe the pathology of thyroid carcinomas detected in the first screening.From 1998 to 2000, 13,243 individuals completed the first cycle of screening examinations. Eighty patients underwent surgery between 1998 and 2004. Intraoperative and postoperative pathologic studies were performed at the Institute of Endocrinology and Metabolism, Kyiv.Pathologic analysis revealed 45 thyroid carcinomas, including 43 papillary thyroid carcinomas (PTCs) (95.6%) and 2 follicular thyroid carcinomas (FTCs) (4.4%). TNM classification (5th edition) of the PTCs included 8 T1 tumors (18.6%), 16 T2 tumors (37.2%), and 19 T4 tumors (44.2%). Fifteen PTCs (34.9%) were N1a,N1b, and 3 PTCs (7.0%) were M1. Among the PTCs, 8 exhibited the classical papillary histologic pattern (18.6%), 14 exhibited a follicular histologic pattern (32.6%), 5 exhibited a solid histologic pattern (11.6%), and 16 exhibited a mixed histologic pattern (37.2%). Both FTCs had a microfollicular‐solid structure. Eleven of 20 cohort members who underwent surgery before the first screening had PTCs. Regional metastases (63.6%) and distant metastases (18.2%) were more common in this group.Multifocal growth, lymphatic and blood vessel invasion, extrathyroid spread, and regional and distant metastases were more frequent in less differentiated PTCs (>30% solid structure). Small carcinomas (≤10 mm) comprised 23.3% of PTCs, and most of those (8 of 10 small carcinomas; 80%) were of the papillary‐follicular subtype and therefore were more differentiated. The solid subtype of PTC was associated with shorter latency, especially in individuals who were diagnosed before the first screening. The histology of post‐Chornobyl cancers is changing with time. Cancer 2006. Published 2006 by the American Cancer Society.

Published
2006
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