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19 results on '"Greenberg, Polina"'

1. Identification of bacteria-derived HLA-bound peptides in melanoma

Author

Kalaora, Shelly, Nagler, Adi, Nejman, Deborah, Alon, Michal, Barbolin, Chaya, Barnea, Eilon, Ketelaars, Steven L. C., Cheng, Kuoyuan, Vervier, Kevin, Shental, Noam, Bussi, Yuval, Rotkopf, Ron, Levy, Ronen, Benedek, Gil, Trabish, Sophie, Dadosh, Tali, Levin-Zaidman, Smadar, Geller, Leore T., Wang, Kun, Greenberg, Polina, Yagel, Gal, Peri, Aviyah, Fuks, Garold, Bhardwaj, Neerupma, Reuben, Alexandre, Hermida, Leandro, Johnson, Sarah B., Galloway-Peña, Jessica R., Shropshire, William C., Bernatchez, Chantale, Haymaker, Cara, Arora, Reetakshi, Roitman, Lior, Eilam, Raya, Weinberger, Adina, Lotan-Pompan, Maya, Lotem, Michal, Admon, Arie, Levin, Yishai, Lawley, Trevor D., Adams, David J., Levesque, Mitchell P., Besser, Michal J., Schachter, Jacob, Golani, Ofra, Segal, Eran, Geva-Zatorsky, Naama, Ruppin, Eytan, Kvistborg, Pia, Peterson, Scott N., Wargo, Jennifer A., Straussman, Ravid, and Samuels, Yardena

Published
2021
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2. Pharmacologic Inhibition of Nonsense-Mediated Decay Induces Anti-Tumour Immunogenicity in Ex Vivo Patient Tumours

Author

Vendramin, Roberto, primary, Fu, Hongchang, additional, Zhao, Yue, additional, Fernandez Patel, Shanila, additional, Qian, Danwen, additional, Ligammari, Lorena, additional, Levy, Ronen, additional, Greenberg, Polina, additional, Castro, Andrea, additional, Thakkar, Krupa, additional, Nguyen, Lisa, additional, Beattie, Gordon, additional, Murai, Jun, additional, Karagianni, Despoina, additional, Shah, Mansi, additional, Vlckova, Petra, additional, Rodriguez-Justo, Manuel, additional, Sng, Christopher C.T., additional, Simpson, Benjamin S., additional, Djikstra, Krijn K., additional, Bartok, Osnat, additional, Galvez-Cancino, Felipe, additional, Consortium, The TRACERx, additional, Gronroos, Eva, additional, Dann, Stephen, additional, Quezada, Sergio A., additional, Reading, James, additional, Samuels, Yardena, additional, Swanton, Charles, additional, and Litchfield, Kevin, additional

Published
2024
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4. Combined presentation and immunogenicity analysis reveals a recurrent RAS.Q61K neoantigen in melanoma

Author

Peri, Aviyah, Greenstein, Erez, Alon, Michal, Pai, Joy A., Dingjan, Tamir, Reich- Zeliger, Shlomit, Barnea, Eilon, Barbolin, Chaya, Levy, Ronen, Arnedo-Pac, Claudia, Kalaora, Shelly, Dassa, Bareket, Feldmesser, Ester, Shang, Ping, Greenberg, Polina, Levin, Yishai, Benedek, Gil, Levesque, Mitchell P., Adams, David J., Lotem, Michal, Wilmott, James S., Scolyer, Richard A., Jonsson, Goran B., Admon, Arie, Rosenberg, Steven A., Cohen, Cyrille J., Niv, Masha Y., Lopez- Bigas, Nuria, Satpathy, Ansuman T., Friedman, Nir, and Samuels, Yardena

Subjects
HLA histocompatibility antigens -- Identification and classification -- Genetic aspects, Immune response -- Genetic aspects, Tumor antigens -- Genetic aspects -- Identification and classification, Melanoma -- Diagnosis -- Genetic aspects, Histocompatibility antigens -- Identification and classification -- Genetic aspects, Guanosine triphosphatase -- Genetic aspects -- Health aspects, Health care industry
Abstract

Neoantigens are now recognized drivers of the antitumor immune response. Recurrent neoantigens, shared among groups of patients, have thus become increasingly coveted therapeutic targets. Here, we report on the data-driven identification of a robustly presented, immunogenic neoantigen that is derived from the combination of HLA-A*01:01 and RAS.Q61K. Analysis of large patient cohorts indicated that this combination applies to 3% of patients with melanoma. Using HLA peptidomics, we were able to demonstrate robust endogenous presentation of the neoantigen in 10 tumor samples. We detected specific reactivity to the mutated peptide within tumor-infiltrating lymphocytes (TILs) from 2 unrelated patients, thus confirming its natural immunogenicity. We further investigated the neoantigen-specific clones and their T cell receptors (TCRs) via a combination of TCR sequencing, TCR overexpression, functional assays, and single-cell transcriptomics. Our analysis revealed a diverse repertoire of neoantigen-specific clones with both intra- and interpatient TCR similarities. Moreover, 1 dominant clone proved to cross-react with the highly prevalent RAS.Q61R variant. Transcriptome analysis revealed a high association of TCR clones with specific T cell phenotypes in response to cognate melanoma, with neoantigen-specific cells showing an activated and dysfunctional phenotype. Identification of recurrent neoantigens and their reactive TCRs can promote 'off-the-shelf' precision immunotherapies, alleviating limitations of personalized treatments., Introduction Immunotherapy sparked new hope for oncology in recent years, due to its remarkable ability to induce long-term tumor regression of metastatic cancer. This feature is shared across immunotherapeutic modalities, [...]

Published
2021
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5. Supplementary Movies 7-9 from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, primary, Feferman, Tali, primary, Barnea, Eilon, primary, Greenstein, Erez, primary, Reshef, Dan, primary, Tirosh, Itay, primary, Reuben, Alexandre, primary, Patkar, Sushant, primary, Levy, Ronen, primary, Quinkhardt, Juliane, primary, Omokoko, Tana, primary, Qutob, Nouar, primary, Golani, Ofra, primary, Zhang, Jianhua, primary, Mao, Xizeng, primary, Song, Xingzhi, primary, Bernatchez, Chantale, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Creasy, Caitlin, primary, Greenberg, Polina, primary, Carter, Brett W., primary, Cooper, Zachary A., primary, Rosenberg, Steven A., primary, Lotem, Michal, primary, Sahin, Ugur, primary, Shakhar, Guy, primary, Ruppin, Eytan, primary, Wargo, Jennifer A., primary, Friedman, Nir, primary, Admon, Arie, primary, and Samuels, Yardena, primary

Published
2023
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6. Supplementary Movies 4-6 from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, primary, Feferman, Tali, primary, Barnea, Eilon, primary, Greenstein, Erez, primary, Reshef, Dan, primary, Tirosh, Itay, primary, Reuben, Alexandre, primary, Patkar, Sushant, primary, Levy, Ronen, primary, Quinkhardt, Juliane, primary, Omokoko, Tana, primary, Qutob, Nouar, primary, Golani, Ofra, primary, Zhang, Jianhua, primary, Mao, Xizeng, primary, Song, Xingzhi, primary, Bernatchez, Chantale, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Creasy, Caitlin, primary, Greenberg, Polina, primary, Carter, Brett W., primary, Cooper, Zachary A., primary, Rosenberg, Steven A., primary, Lotem, Michal, primary, Sahin, Ugur, primary, Shakhar, Guy, primary, Ruppin, Eytan, primary, Wargo, Jennifer A., primary, Friedman, Nir, primary, Admon, Arie, primary, and Samuels, Yardena, primary

Published
2023
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7. Data from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, primary, Feferman, Tali, primary, Barnea, Eilon, primary, Greenstein, Erez, primary, Reshef, Dan, primary, Tirosh, Itay, primary, Reuben, Alexandre, primary, Patkar, Sushant, primary, Levy, Ronen, primary, Quinkhardt, Juliane, primary, Omokoko, Tana, primary, Qutob, Nouar, primary, Golani, Ofra, primary, Zhang, Jianhua, primary, Mao, Xizeng, primary, Song, Xingzhi, primary, Bernatchez, Chantale, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Creasy, Caitlin, primary, Greenberg, Polina, primary, Carter, Brett W., primary, Cooper, Zachary A., primary, Rosenberg, Steven A., primary, Lotem, Michal, primary, Sahin, Ugur, primary, Shakhar, Guy, primary, Ruppin, Eytan, primary, Wargo, Jennifer A., primary, Friedman, Nir, primary, Admon, Arie, primary, and Samuels, Yardena, primary

Published
2023
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8. Supplementary Movies 1-3 from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, primary, Feferman, Tali, primary, Barnea, Eilon, primary, Greenstein, Erez, primary, Reshef, Dan, primary, Tirosh, Itay, primary, Reuben, Alexandre, primary, Patkar, Sushant, primary, Levy, Ronen, primary, Quinkhardt, Juliane, primary, Omokoko, Tana, primary, Qutob, Nouar, primary, Golani, Ofra, primary, Zhang, Jianhua, primary, Mao, Xizeng, primary, Song, Xingzhi, primary, Bernatchez, Chantale, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Creasy, Caitlin, primary, Greenberg, Polina, primary, Carter, Brett W., primary, Cooper, Zachary A., primary, Rosenberg, Steven A., primary, Lotem, Michal, primary, Sahin, Ugur, primary, Shakhar, Guy, primary, Ruppin, Eytan, primary, Wargo, Jennifer A., primary, Friedman, Nir, primary, Admon, Arie, primary, and Samuels, Yardena, primary

Published
2023
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9. Supplementary methods from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, primary, Feferman, Tali, primary, Barnea, Eilon, primary, Greenstein, Erez, primary, Reshef, Dan, primary, Tirosh, Itay, primary, Reuben, Alexandre, primary, Patkar, Sushant, primary, Levy, Ronen, primary, Quinkhardt, Juliane, primary, Omokoko, Tana, primary, Qutob, Nouar, primary, Golani, Ofra, primary, Zhang, Jianhua, primary, Mao, Xizeng, primary, Song, Xingzhi, primary, Bernatchez, Chantale, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Creasy, Caitlin, primary, Greenberg, Polina, primary, Carter, Brett W., primary, Cooper, Zachary A., primary, Rosenberg, Steven A., primary, Lotem, Michal, primary, Sahin, Ugur, primary, Shakhar, Guy, primary, Ruppin, Eytan, primary, Wargo, Jennifer A., primary, Friedman, Nir, primary, Admon, Arie, primary, and Samuels, Yardena, primary

Published
2023
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10. Supplementary Tables 1, 2, 4, 5, 8, 10, 13, 14, 15 from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, primary, Feferman, Tali, primary, Barnea, Eilon, primary, Greenstein, Erez, primary, Reshef, Dan, primary, Tirosh, Itay, primary, Reuben, Alexandre, primary, Patkar, Sushant, primary, Levy, Ronen, primary, Quinkhardt, Juliane, primary, Omokoko, Tana, primary, Qutob, Nouar, primary, Golani, Ofra, primary, Zhang, Jianhua, primary, Mao, Xizeng, primary, Song, Xingzhi, primary, Bernatchez, Chantale, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Creasy, Caitlin, primary, Greenberg, Polina, primary, Carter, Brett W., primary, Cooper, Zachary A., primary, Rosenberg, Steven A., primary, Lotem, Michal, primary, Sahin, Ugur, primary, Shakhar, Guy, primary, Ruppin, Eytan, primary, Wargo, Jennifer A., primary, Friedman, Nir, primary, Admon, Arie, primary, and Samuels, Yardena, primary

Published
2023
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11. Supplementary Tables 3, 6, 7, 9, 11, 12 from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, primary, Feferman, Tali, primary, Barnea, Eilon, primary, Greenstein, Erez, primary, Reshef, Dan, primary, Tirosh, Itay, primary, Reuben, Alexandre, primary, Patkar, Sushant, primary, Levy, Ronen, primary, Quinkhardt, Juliane, primary, Omokoko, Tana, primary, Qutob, Nouar, primary, Golani, Ofra, primary, Zhang, Jianhua, primary, Mao, Xizeng, primary, Song, Xingzhi, primary, Bernatchez, Chantale, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Creasy, Caitlin, primary, Greenberg, Polina, primary, Carter, Brett W., primary, Cooper, Zachary A., primary, Rosenberg, Steven A., primary, Lotem, Michal, primary, Sahin, Ugur, primary, Shakhar, Guy, primary, Ruppin, Eytan, primary, Wargo, Jennifer A., primary, Friedman, Nir, primary, Admon, Arie, primary, and Samuels, Yardena, primary

Published
2023
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12. Supplementary Figures 1-17 from Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, primary, Feferman, Tali, primary, Barnea, Eilon, primary, Greenstein, Erez, primary, Reshef, Dan, primary, Tirosh, Itay, primary, Reuben, Alexandre, primary, Patkar, Sushant, primary, Levy, Ronen, primary, Quinkhardt, Juliane, primary, Omokoko, Tana, primary, Qutob, Nouar, primary, Golani, Ofra, primary, Zhang, Jianhua, primary, Mao, Xizeng, primary, Song, Xingzhi, primary, Bernatchez, Chantale, primary, Haymaker, Cara, primary, Forget, Marie-Andrée, primary, Creasy, Caitlin, primary, Greenberg, Polina, primary, Carter, Brett W., primary, Cooper, Zachary A., primary, Rosenberg, Steven A., primary, Lotem, Michal, primary, Sahin, Ugur, primary, Shakhar, Guy, primary, Ruppin, Eytan, primary, Wargo, Jennifer A., primary, Friedman, Nir, primary, Admon, Arie, primary, and Samuels, Yardena, primary

Published
2023
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13. Identification of presented SARS-CoV-2 HLA class I and HLA class II peptides using HLA peptidomics

Author

Nagler, Adi, primary, Kalaora, Shelly, additional, Barbolin, Chaya, additional, Gangaev, Anastasia, additional, Ketelaars, Steven L.C., additional, Alon, Michal, additional, Pai, Joy, additional, Benedek, Gil, additional, Yahalom-Ronen, Yfat, additional, Erez, Noam, additional, Greenberg, Polina, additional, Yagel, Gal, additional, Peri, Aviyah, additional, Levin, Yishai, additional, Satpathy, Ansuman T., additional, Bar-Haim, Erez, additional, Paran, Nir, additional, Kvistborg, Pia, additional, and Samuels, Yardena, additional

Published
2021
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14. 672 Identification of microbial-derived HLA-bound peptides in melanoma

Author

Nagler, Adi, primary, Kalaora, Shelly, additional, Rosenberg, Deborah Gitta, additional, Alon, Michal, additional, Barnea, Eilon, additional, Levy, Ronen, additional, Vervier, Kevin, additional, Trabish, Sophie, additional, Dadosh, Tali, additional, Zaidman, Smadar, additional, Geller, Leore, additional, Greenberg, Polina, additional, Bhardwaj, Neerupma, additional, Reuben, Alexandre, additional, Arora, Reetakshi, additional, Lotem, Michal, additional, Admon, Arie, additional, Levin, Yishai, additional, Lawley, Trevor, additional, Adams, David, additional, Geva-Zatorsky, Naama, additional, Wargo, Jennifer, additional, Straussman, Ravid, additional, and Samuels, Yardena, additional

Published
2020
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15. Author Correction: RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells

Author

Qutob, Nouar, primary, Masuho, Ikuo, additional, Alon, Michal, additional, Emmanuel, Rafi, additional, Cohen, Isadora, additional, Di Pizio, Antonella, additional, Madore, Jason, additional, Elkahloun, Abdel, additional, Ziv, Tamar, additional, Levy, Ronen, additional, Gartner, Jared J., additional, Hill, Victoria K., additional, Lin, Jimmy C., additional, Hevroni, Yael, additional, Greenberg, Polina, additional, Brodezki, Alexandra, additional, Rosenberg, Steven A., additional, Kosloff, Mickey, additional, Hayward, Nicholas K., additional, Admon, Arie, additional, Niv, Masha Y., additional, Scolyer, Richard A., additional, Martemyanov, Kirill A., additional, and Samuels, Yardena, additional

Published
2019
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17. Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Author

Kalaora, Shelly, primary, Wolf, Yochai, additional, Feferman, Tali, additional, Barnea, Eilon, additional, Greenstein, Erez, additional, Reshef, Dan, additional, Tirosh, Itay, additional, Reuben, Alexandre, additional, Patkar, Sushant, additional, Levy, Ronen, additional, Quinkhardt, Juliane, additional, Omokoko, Tana, additional, Qutob, Nouar, additional, Golani, Ofra, additional, Zhang, Jianhua, additional, Mao, Xizeng, additional, Song, Xingzhi, additional, Bernatchez, Chantale, additional, Haymaker, Cara, additional, Forget, Marie-Andrée, additional, Creasy, Caitlin, additional, Greenberg, Polina, additional, Carter, Brett W., additional, Cooper, Zachary A., additional, Rosenberg, Steven A., additional, Lotem, Michal, additional, Sahin, Ugur, additional, Shakhar, Guy, additional, Ruppin, Eytan, additional, Wargo, Jennifer A., additional, Friedman, Nir, additional, Admon, Arie, additional, and Samuels, Yardena, additional

Published
2018
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19. RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells

Author

Qutob, Nouar, primary, Masuho, Ikuo, additional, Alon, Michal, additional, Emmanuel, Rafi, additional, Cohen, Isadora, additional, Di Pizio, Antonella, additional, Madore, Jason, additional, Elkahloun, Abdel, additional, Ziv, Tamar, additional, Levy, Ronen, additional, Gartner, Jared J., additional, Hill, Victoria K., additional, Lin, Jimmy C., additional, Hevroni, Yael, additional, Greenberg, Polina, additional, Brodezki, Alexandra, additional, Rosenberg, Steven A., additional, Kosloff, Mickey, additional, Hayward, Nicholas K., additional, Admon, Arie, additional, Niv, Masha Y., additional, Scolyer, Richard A., additional, Martemyanov, Kirill A., additional, and Samuels, Yardena, additional

Published
2018
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