Search

Your search keyword '"Green, Marcus"' showing total 280 results
Start Over Author "Green, Marcus"
280 results on '"Green, Marcus"'

2. A treatment strategy with nifedipine versus labetalol for women with pregnancy hypertension: study protocol for a randomised controlled trial (Giant PANDA)

Author

Ashworth, Danielle, Battersby, Cheryl, Bick, Debra, Green, Marcus, Hardy, Pollyanna, Leighton, Lisa, Magee, Laura A., Maher, Alisha, McManus, Richard J., Moakes, Catherine, Morris, R. Katie, Nelson-Piercy, Catherine, Sparkes, Jenie, Rivero-Arias, Oliver, Webb, Andrew, Wilson, Hannah, Myers, Jenny, and Chappell, Lucy C.

Published
2023
Full Text
View/download PDF

4. Repeat placental growth factor-based testing in women with suspected preterm pre-eclampsia (PARROT-2): a multicentre, parallel-group, superiority, randomised controlled trial

Author

Ahuja, Ashwin, Alexander, Hazel, Arya, Rita, Bahl, Rachna, Bapir, Mihraban, Barry, Natalie, Basak, Sambita, Bishop, Linda, Biswas, Chandrima, Campbell, Deniesha, Chados, Nikolaos, Davies, Sarah, Davison, Jessica, Dudgeon, Lucy, Ferry, Orla, Ficquet, Jo, Girling, Jo, Gowans, Sharon, Hewitt, Lesley, Hinshaw, Kim, Holt, Siobhan, Jack, Elaine, Jennings, Jacqui, Maher, Martin, McBean, Mel, McDonnell, Sian, Mehta, Anku, Morris, Katie, O'Brien, Clare, Obiozo, Chinwe, Peers, Beth, Pickering, Francis, Regan, Maeve, Rich, Mel, Roughley, Lindsay, Ryan, Grace, Sharp, Andrew, Smart, Brittany, Smith, Annabel, Stirrat, Laura, Thompson, Hilary, Trepte, Lauren, Verghese, Lynda, Willson, Seren, Yulia, Angela, Hurrell, Alice, Webster, Louise, Sparkes, Jenie, Battersby, Cheryl, Brockbank, Anna, Clark, Katherine, Duhig, Kate E, Gill, Carolyn, Green, Marcus, Hunter, Rachael M, Seed, Paul T, Vowles, Zoe, Myers, Jenny, Shennan, Andrew H, and Chappell, Lucy C

Published
2024
Full Text
View/download PDF

10. Repeat placental growth factor-based testing in women with suspected preterm pre-eclampsia (PARROT-2): a multicentre, parallel-group, superiority, randomised controlled trial

Author

Hurrell, Alice, primary, Webster, Louise, additional, Sparkes, Jenie, additional, Battersby, Cheryl, additional, Brockbank, Anna, additional, Clark, Katherine, additional, Duhig, Kate E, additional, Gill, Carolyn, additional, Green, Marcus, additional, Hunter, Rachael M, additional, Seed, Paul T, additional, Vowles, Zoe, additional, Myers, Jenny, additional, Shennan, Andrew H, additional, Chappell, Lucy C, additional, Ahuja, Ashwin, additional, Alexander, Hazel, additional, Arya, Rita, additional, Bahl, Rachna, additional, Bapir, Mihraban, additional, Barry, Natalie, additional, Basak, Sambita, additional, Bishop, Linda, additional, Biswas, Chandrima, additional, Campbell, Deniesha, additional, Chados, Nikolaos, additional, Davies, Sarah, additional, Davison, Jessica, additional, Dudgeon, Lucy, additional, Ferry, Orla, additional, Ficquet, Jo, additional, Girling, Jo, additional, Gowans, Sharon, additional, Hewitt, Lesley, additional, Hinshaw, Kim, additional, Holt, Siobhan, additional, Jack, Elaine, additional, Jennings, Jacqui, additional, Maher, Martin, additional, McBean, Mel, additional, McDonnell, Sian, additional, Mehta, Anku, additional, Morris, Katie, additional, O'Brien, Clare, additional, Obiozo, Chinwe, additional, Peers, Beth, additional, Pickering, Francis, additional, Regan, Maeve, additional, Rich, Mel, additional, Roughley, Lindsay, additional, Ryan, Grace, additional, Sharp, Andrew, additional, Smart, Brittany, additional, Smith, Annabel, additional, Stirrat, Laura, additional, Thompson, Hilary, additional, Trepte, Lauren, additional, Verghese, Lynda, additional, Willson, Seren, additional, and Yulia, Angela, additional

Published
2024
Full Text
View/download PDF

12. Repeat Placental Growth Factor-Based Testing in Women With Suspected Preterm Preeclampsia: A Stratified Analysis of the PARROT-2 Trial.

Author

Hurrell, Alice, Webster, Louise, Sparkes, Jenie, Battersby, Cheryl, Brockbank, Anna, Clark, Katherine, Duhig, Kate E., Gill, Carolyn, Green, Marcus, Hunter, Rachael M., Seed, Paul T., Vowles, Zoe, Myers, Jenny, Shennan, Andrew H., and Chappell, Lucy C.

Abstract

BACKGROUND: PlGF (placental growth factor)-based testing reduces severe maternal adverse outcomes. Repeat PlGF-based testing is not associated with improved perinatal or maternal outcomes. This planned secondary analysis aimed to determine whether there is a subgroup of women who benefit from repeat testing. METHODS: Pregnant individuals with suspected preterm preeclampsia were randomized to repeat revealed PlGF-based testing, compared with usual care where testing was concealed. Perinatal and maternal outcomes were stratified by trial group, by initial PlGF-based test result, and by PlGF-based test type (PlGF or sFlt-1 [soluble fms-like tyrosine kinase-1]/PlGF ratio). RESULTS: A total of 1252 pregnant individuals were included. Abnormal initial PlGF-based test identified a more severe phenotype of preeclampsia, at increased risk of adverse maternal and perinatal outcomes. Repeat testing was not significantly associated with clinical benefit in women with abnormal initial results. Of women with a normal initial result, 20% developed preeclampsia, with the majority at least 3 to 4 weeks after initial presentation. Repeat test results were more likely to change from normal to abnormal in symptomatic women (112/415; 27%) compared with asymptomatic women (163/890; 18%). A higher proportion of symptomatic women who changed from normal to abnormal were diagnosed with preeclampsia, compared with asymptomatic women. CONCLUSIONS: Our results do not demonstrate evidence of the clinical benefit of repeating PlGF-based testing if the initial result is abnormal. Judicious use of repeat PlGF-based testing to stratify risk may be considered at least 2 weeks after a normal initial test result, particularly in women who have symptoms or signs of preeclampsia. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

16. Social networks and residential mobility in later life : the effects of moving on social network supportive capacity amongst older people in the UK

Author

Green, Marcus, Falkingham, Jane, and Evandrou, Maria

Subjects
300, HQ The family. Marriage. Woman
Abstract

This is an interdisciplinary PhD research project, spanning the ESRC Centre for Population Change and the Centre for Research on Ageing. Using British Household Panel Survey data, the thesis aims to prove that undertaking a residential move changes the supportive capacity of one’s social network in later life. The study first investigates the determinants of moving home in later life. It then conceptualises and constructs the social networks of older people in the UK, considering key attributes such as network size, frequency, proximity and functions and examines the effects of moving home on these measures. The analysis finds that the incidence of residential mobility is associated with, amongst other things, becoming widowed and experiencing a negative change in health or financial circumstance. Furthermore older people are likely to experience disruption to the supportive capacity of their companionship and community networks following a move. This research has important implications for policy as any damaging effects on an older person’s informal support network may have consequences for their health outcomes and in turn lead to an increased dependence on formal health and social care services at the places to which they move.

Published
2014

21. Risk factors for pre‐eclampsia in clinical practice guidelines: Comparison with the evidence.

Author

Elawad, Terteel, Scott, Georgia, Bone, Jeffrey N., Elwell, Helen, Lopez, Cristina Escalona, Filippi, Veronique, Green, Marcus, Khalil, Asma, Kinshella, Mai‐Lei W., Mistry, Hiten D., Pickerill, Kelly, Shanmugam, Reshma, Singer, Joel, Townsend, Rosemarie, Tsigas, Eleni Z., Vidler, Marianne, Volvert, Marie‐Laure, von Dadelszen, Peter, and Magee, Laura A.

Subjects
ECLAMPSIA, PREECLAMPSIA, BLOOD pressure, PREGNANT women, PREHYPERTENSION
Abstract

Objective: To compare pre‐eclampsia risk factors identified by clinical practice guidelines (CPGs) with risk factors from hierarchical evidence review, to guide pre‐eclampsia prevention. Design: Our search strategy provided hierarchical evidence of relationships between risk factors and pre‐eclampsia using Medline (Ovid), searched from January 2010 to January 2021. Setting: Published studies and CPGs. Population Pregnant women. Methods: We evaluated the strength of association and quality of evidence (GRADE). CPGs (n = 15) were taken from a previous systematic review. Main outcome measure: Pre‐eclampsia. Results: Of 78 pre‐eclampsia risk factors, 13 (16.5%) arise only during pregnancy. Strength of association was usually 'probable' (n = 40, 51.3%) and the quality of evidence was low (n = 35, 44.9%). The 'major' and 'moderate' risk factors proposed by 8/15 CPGs were not well aligned with the evidence; of the ten 'major' risk factors (alone warranting aspirin prophylaxis), associations with pre‐eclampsia were definite (n = 4), probable (n = 5) or possible (n = 1), based on moderate (n = 4), low (n = 5) or very low (n = 1) quality evidence. Obesity ('moderate' risk factor) was definitely associated with pre‐eclampsia (high‐quality evidence). The other ten 'moderate' risk factors had probable (n = 8), possible (n = 1) or no (n = 1) association with pre‐eclampsia, based on evidence of moderate (n = 1), low (n = 5) or very low (n = 4) quality. Three risk factors not identified by the CPGs had probable associations (high quality): being overweight; 'prehypertension' at booking; and blood pressure of 130–139/80–89 mmHg in early pregnancy. Conclusions: Pre‐eclampsia risk factors in CPGs are poorly aligned with evidence, particularly for the strongest risk factor of obesity. There is a lack of distinction between risk factors identifiable in early pregnancy and those arising later. A refresh of the strategies advocated by CPGs is needed. Linked article: This article is commented on by Stefan C. Kane et al., pp. 63 in this issue. To view this mini commentary visit https://doi.org/10.1111/1471‐0528.17311. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

22. 'Effective' Mathematics Teaching of African American Adolescents and the Development of a Mathematics Identity

Author

Green, Marcus Allen

Abstract

In order to increase mathematics achievement, persistence, and participation in mathematics-related careers and majors for African American adolescents, researchers have discussed the need for students to develop positive mathematical identities (English-Clarke, Slaughter-Defoe, & Martin, 2012; Gutstein, 2003; Larnell, 2013; Martin, 2000, 2006, 2007, 2009). These studies and others have implied that the classroom teacher plays a critical role in either bolstering or limiting the formation of a positive mathematics identity of the students in their classes. However, there still remains a lack of clear understanding of how mathematics identity manifests and operates in African American students. In addition, research has yet to yield lucid descriptions of the characteristics of an effective mathematics teacher for African American adolescents that supports positive mathematics identity development. This mixed-method study examines the relationship between developing racial and mathematical identities of 102 African American adolescent students in mathematics across five public secondary schools. Quantitative research centred on student surveys that probed on various dimensions of their mathematical proclivities and their racial-mathematical beliefs. This study also included a qualitative investigation into the characteristics of two designated "effective" teachers from two adjacent school districts in the rural, southeastern U.S. Findings indicate a positive association between students' racial identity and their overall mathematics identity and provide support of mathematics identity theory in contemporary research (Martin, 2000). In addition, findings showed descriptions of teachers designated as "effective" by their beliefs, demeanors, and practices engaging African American adolescents. The results unearth the resilience of problematic perspectives and practices among the sample of teachers that could impede further progress of African American adolescents in mathematics. The study critically examines the implications regarding what it means to be an "effective" mathematics teacher of African American adolescents. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]

Published
2016

25. Supplementary Methods from Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non–Small Cell Lung Cancer

Author

Skwarski, Michael, primary, McGowan, Daniel R., primary, Belcher, Elizabeth, primary, Di Chiara, Francesco, primary, Stavroulias, Dionisios, primary, McCole, Mark, primary, Derham, Jennifer L., primary, Chu, Kwun-Ye, primary, Teoh, Eugene, primary, Chauhan, Jagat, primary, O’Reilly, Dawn, primary, Harris, Benjamin H.L., primary, Macklin, Philip S., primary, Bull, Joshua A., primary, Green, Marcus, primary, Rodriguez-Berriguete, Gonzalo, primary, Prevo, Remko, primary, Folkes, Lisa K., primary, Campo, Leticia, primary, Ferencz, Petra, primary, Croal, Paula L., primary, Flight, Helen, primary, Qi, Cathy, primary, Holmes, Jane, primary, O’Connor, James P.B., primary, Gleeson, Fergus V., primary, McKenna, W. Gillies, primary, Harris, Adrian L., primary, Bulte, Daniel, primary, Buffa, Francesca M., primary, Macpherson, Ruth E., primary, and Higgins, Geoff S., primary

Published
2023
Full Text
View/download PDF

26. Supplementary Data from Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non–Small Cell Lung Cancer

Author

Skwarski, Michael, primary, McGowan, Daniel R., primary, Belcher, Elizabeth, primary, Di Chiara, Francesco, primary, Stavroulias, Dionisios, primary, McCole, Mark, primary, Derham, Jennifer L., primary, Chu, Kwun-Ye, primary, Teoh, Eugene, primary, Chauhan, Jagat, primary, O’Reilly, Dawn, primary, Harris, Benjamin H.L., primary, Macklin, Philip S., primary, Bull, Joshua A., primary, Green, Marcus, primary, Rodriguez-Berriguete, Gonzalo, primary, Prevo, Remko, primary, Folkes, Lisa K., primary, Campo, Leticia, primary, Ferencz, Petra, primary, Croal, Paula L., primary, Flight, Helen, primary, Qi, Cathy, primary, Holmes, Jane, primary, O’Connor, James P.B., primary, Gleeson, Fergus V., primary, McKenna, W. Gillies, primary, Harris, Adrian L., primary, Bulte, Daniel, primary, Buffa, Francesca M., primary, Macpherson, Ruth E., primary, and Higgins, Geoff S., primary

Published
2023
Full Text
View/download PDF

27. Hypertensive disorders of pregnancy.

Author

Wu, Pensée, Green, Marcus, and Myers, Jenny E.

Subjects
PREECLAMPSIA diagnosis, HYPERTENSION, HYPERTENSION in pregnancy, CARDIOVASCULAR diseases in pregnancy, PREECLAMPSIA, DISEASE complications
Published
2023
Full Text
View/download PDF

30. Planned delivery for pre-eclampsia between 34 and 37 weeks of gestation: the PHOENIX RCT

Author

Chappell, Lucy C, primary, Brocklehurst, Peter, additional, Green, Marcus, additional, Hardy, Pollyanna, additional, Hunter, Rachael, additional, Beardmore-Gray, Alice, additional, Bowler, Ursula, additional, Brockbank, Anna, additional, Chiocchia, Virginia, additional, Cox, Alice, additional, Duhig, Kate, additional, Fleminger, Jessica, additional, Gill, Carolyn, additional, Greenland, Melanie, additional, Hendy, Eleanor, additional, Kennedy, Ann, additional, Leeson, Paul, additional, Linsell, Louise, additional, McCarthy, Fergus P, additional, O’Driscoll, Jamie, additional, Placzek, Anna, additional, Poston, Lucilla, additional, Robson, Stephen, additional, Rushby, Pauline, additional, Sandall, Jane, additional, Scholtz, Laura, additional, Seed, Paul T, additional, Sparkes, Jenie, additional, Stanbury, Kayleigh, additional, Tohill, Sue, additional, Thilaganathan, Basky, additional, Townend, John, additional, Juszczak, Edmund, additional, Marlow, Neil, additional, and Shennan, Andrew, additional

Published
2022
Full Text
View/download PDF

31. sj-docx-1-ajs-10.1177_03635465221141907 – Supplemental material for A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee

Author

Snow, Martyn, Middleton, Lee, Mehta, Samir, Roberts, Andrew, Grey, Richard, Richardson, James, Kuiper, Jan Herman, Smith, Anthony, White, Steve, Roberts, Simon, Griffiths, David, Mohammed, Aslam, Moholkar, Kirti, Ashraf, Tanweer, Green, Marcus, Hutchinson, James, Bhullar, Tony, Chitnis, Sanjeev, Shaw, Andrew, van Niekerk, Louw, Hui, Anthony, Drogset, Jon Olav, Knutsen, Gunnar, McNicholas, Mike, Bowditch, Mark, Johnson, David, Turner, Philip, Chugh, Sanjiv, Hunt, Neil, Ali, Salman, Palmer, Simon, Perry, Andrew, Davidson, Alastair, Hill, Peter, Deo, Sunny, Satish, Venkat, Radford, Michael, Langstaff, Ron, Houlihan-Burne, David, Spicer, Dominic, Phaltankar, Padman, Hegab, Ahmed, Marsh, David, Cannon, Steve, Briggs, Tim, Pollock, Rob, Carrington, Richard, Skinner, John, Bentley, George, Price, Andrew, Schranz, Peter, Mandalia, Vipul, and O’Brien, Shaun

Subjects
FOS: Clinical medicine, 110323 Surgery, 110604 Sports Medicine, FOS: Health sciences, 110314 Orthopaedics
Abstract

Supplemental material, sj-docx-1-ajs-10.1177_03635465221141907 for A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee by Martyn Snow, Lee Middleton, Samir Mehta, Andrew Roberts, Richard Grey, James Richardson, Jan Herman Kuiper, Anthony Smith, Steve White, Simon Roberts, David Griffiths, Aslam Mohammed, Kirti Moholkar, Tanweer Ashraf, Marcus Green, James Hutchinson, Tony Bhullar, Sanjeev Chitnis, Andrew Shaw, Louw van Niekerk, Anthony Hui, Jon Olav Drogset, Gunnar Knutsen, Mike McNicholas, Mark Bowditch, David Johnson, Philip Turner, Sanjiv Chugh, Neil Hunt, Salman Ali, Simon Palmer, Andrew Perry, Alastair Davidson, Peter Hill, Sunny Deo, Venkat Satish, Michael Radford, Ron Langstaff, David Houlihan-Burne, Dominic Spicer, Padman Phaltankar, Ahmed Hegab, David Marsh, Steve Cannon, Tim Briggs, Rob Pollock, Richard Carrington, John Skinner, George Bentley, Andrew Price, Peter Schranz, Vipul Mandalia and Shaun O’Brien in The American Journal of Sports Medicine

Published
2023
Full Text
View/download PDF

34. Two-year follow-up of infant and maternal outcomes after planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): A randomised controlled trial

Author

Beardmore-Gray, Alice, Greenland, Melanie, Linsell, Louise, Juszczak, Edmund, Hardy, Pollyanna, Placzek, Anna, Hunter, Rachael, Sparkes, Jenie, Green, Marcus, Shennan, Andrew, Marlow, Neil, Chappell, Lucy C., and the PHOENIX Study Group

Subjects
Obstetrics and Gynecology
Abstract

Objective: We evaluated the best time to initiate delivery in late preterm pre-eclampsia in order to optimise long-term infant and maternal outcomes. Design: Parallel-group, non-masked, randomised controlled trial. Setting: Forty-six maternity units in the UK. Population: Women with pre-eclampsia between 34+0 and 36+6weeks of gestation, without severe disease, were randomised to planned delivery or expectant management. Main outcome measures: Infant neurodevelopmental outcome at 2 years of age, using the Parent Report of Children’s Abilities – Revised (PARCA-R) composite score. Results: Between 29 September 2014 and 10 December 2018, 901 women were enrolled in the trial, with 450 women allocated to planned delivery and 451 women allocated to expectant management. At the 2-year follow-up, the intention-to-treat analysis population included 276 women (290 infants) allocated to planned delivery and 251 women (256 infants) allocated to expectant management. The mean composite standardised PARCA-R scores were 89.5 (SD18.2) in the planned delivery group and 91.9 (SD18.4) in the expectant management group, with an adjusted mean difference of −2.4 points (95%CI −5.4 to 0.5points). Conclusions: In infants of women with late preterm pre-eclampsia, the average neurodevelopmental assessment at 2 years lies within the normal range, regardless of whether planned delivery or expectant management was pursued. With the lower than anticipated follow-up rate there was limited power to demonstrate that these scores did not differ, but the small between-group difference in PARCA-R scores is unlikely to be clinically important.

Published
2022

37. Placental growth fActor Repeat sampling for Reduction of adverse perinatal Outcomes in women with suspecTed pre-eclampsia: study protocol for a randomised controlled trial (PARROT-2)

Author

Hurrell, Alice Elizabeth, primary, Sparkes, Jenie, additional, Duhig, Kate E, additional, Seed, Paul T, additional, Myers, Jenny, additional, Battersby, Cheryl, additional, Clark, Katherine, additional, Green, Marcus, additional, Hunter, Rachael M, additional, Shennan, Andrew H, additional, Chappell, Lucy C, additional, and Webster, Louise M, additional

Published
2022
Full Text
View/download PDF

38. An Overview of the Gramsci Situation in North America

Author

Green, Marcus E. and Green, Marcus E.

Abstract

This is the Abstract of the English-language article by Marcus Green, giving an overview of the current Gramsci situation in North America, with special regard to the United States.

Published
2022

39. A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee.

Author

Snow, Martyn, Middleton, Lee, Mehta, Samir, Roberts, Andrew, Gray, Richard, Richardson, James, Kuiper, Jan Herman, Smith, Anthony, White, Steve, Roberts, Simon, Griffiths, David, Mohammed, Aslam, Moholkar, Kirti, Ashraf, Tanweer, Green, Marcus, Hutchinson, James, Bhullar, Tony, Chitnis, Sanjeev, Shaw, Andrew, and van Niekerk, Louw

Subjects
CARTILAGE cells, STATISTICS, CONFIDENCE intervals, ARTHROPLASTY, TREATMENT failure, RANDOMIZED controlled trials, TREATMENT effectiveness, CHI-squared test, QUESTIONNAIRES, DESCRIPTIVE statistics, ARTICULAR cartilage injuries, ARTICULAR cartilage, STATISTICAL sampling, DATA analysis, DATA analysis software, ADVERSE health care events
Abstract

Background: There are limited randomized controlled trials with long-term outcomes comparing autologous chondrocyte implantation (ACI) versus alternative forms of surgical cartilage management within the knee. Purpose: To determine at 5 years after surgery whether ACI was superior to alternative forms of cartilage management in patients after a failed previous treatment for chondral or osteochondral defects in the knee. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: In total, 390 participants were randomly assigned to receive either ACI or alternative management. Patients aged 18 to 55 years with one or two symptomatic cartilage defects who had failed 1 previous therapeutic surgical procedure in excess of 6 months prior were included. Dual primary outcome measures were used: (1) patient-completed Lysholm knee score and (2) time from surgery to cessation of treatment benefit. Secondary outcome measures included International Knee Documentation Committee and Cincinnati Knee Rating System scores, as well as number of serious adverse events. Analysis was performed on an intention-to-treat basis. Results: Lysholm scores were improved by 1 year in both groups (15.4 points [95% CI, 11.9 to 18.8] and 15.2 points [95% CI, 11.6 to 18.9]) for ACI and alternative, with this improvement sustained over the duration of the trial. However, no evidence of a difference was found between the groups at 5 years (2.9 points; 95% CI, −1.8 to 7.5; P =.46). Approximately half of the participants (55%; 95% CI, 47% to 64% with ACI) were still experiencing benefit at 5 years, with time to cessation of treatment benefit similar in both groups (hazard ratio, 0.97; 95% CI, 0.72 to 1.32; P >.99). There was a differential effect on Lysholm scores in patients without previous marrow stimulation compared with those with marrow stimulation (P =.03; 6.4 points in favor of ACI; 95% CI, −0.4 to 13.1). More participants experienced a serious adverse event with ACI (P =.02). Conclusion: Over 5 years, there was no evidence of a difference in Lysholm scores between ACI and alternative management in patients who had previously failed treatment. Previous marrow stimulation had a detrimental effect on the outcome of ACI. Registration: International Standard Randomised Controlled Trial Number: 48911177 [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

40. Additional file 5 of Placental growth fActor Repeat sampling for Reduction of adverse perinatal Outcomes in women with suspecTed pre-eclampsia: study protocol for a randomised controlled trial (PARROT-2)

Author

Hurrell, Alice, Sparkes, Jenie, Duhig, Kate, Seed, Paul T., Myers, Jenny, Battersby, Cheryl, Clark, Katherine, Green, Marcus, Hunter, Rachael M., Shennan, Andrew H., Chappell, Lucy C., and Webster, Louise

Abstract

Additional file 5. Health economics analysis plan

Published
2022
Full Text
View/download PDF

41. Additional file 2 of Placental growth fActor Repeat sampling for Reduction of adverse perinatal Outcomes in women with suspecTed pre-eclampsia: study protocol for a randomised controlled trial (PARROT-2)

Author

Hurrell, Alice, Sparkes, Jenie, Duhig, Kate, Seed, Paul T., Myers, Jenny, Battersby, Cheryl, Clark, Katherine, Green, Marcus, Hunter, Rachael M., Shennan, Andrew H., Chappell, Lucy C., and Webster, Louise

Abstract

Additional file 2. Consent form

Published
2022
Full Text
View/download PDF

42. Additional file 1 of Postnatal health and care following hypertensive disorders in pregnancy: a prospective cohort study (BPiPP study)

Author

Ashworth, Danielle C., Bowen, Liza, Maule, Sophie P., Seed, Paul T., Green, Marcus, Bick, Debra, and Chappell, Lucy C.

Abstract

Additional file 1: Supplementary Table 1. Maternal demographics at postnatal enrolment. Supplementary Table 2. Labour, birth, and postnatal characteristics at postnatal enrolment. Supplementary Table 3. Study specific postnatal enrolment baseline characteristics. Supplementary Table 4. Primary and main secondary outcomes at 3 months postnatal. Supplementary Table 5. Postnatal care at 3 months postnatal and opinions on future pregnancies (self-reported). Supplementary Table 6. Maternal demographics at postnatal enrolment by responder status. Supplementary Table 7. Characteristics of labour, birth and post-delivery postnatal stay at postnatal enrolment by responder status. Supplementary Table 8. Study specific outcomes at postnatal enrolment by responder status.

Published
2022
Full Text
View/download PDF

43. Additional file 4 of Placental growth fActor Repeat sampling for Reduction of adverse perinatal Outcomes in women with suspecTed pre-eclampsia: study protocol for a randomised controlled trial (PARROT-2)

Author

Hurrell, Alice, Sparkes, Jenie, Duhig, Kate, Seed, Paul T., Myers, Jenny, Battersby, Cheryl, Clark, Katherine, Green, Marcus, Hunter, Rachael M., Shennan, Andrew H., Chappell, Lucy C., and Webster, Louise

Abstract

Additional file 4. Statistical analysis plan

Published
2022
Full Text
View/download PDF

44. Additional file 1 of Placental growth fActor Repeat sampling for Reduction of adverse perinatal Outcomes in women with suspecTed pre-eclampsia: study protocol for a randomised controlled trial (PARROT-2)

Author

Hurrell, Alice, Sparkes, Jenie, Duhig, Kate, Seed, Paul T., Myers, Jenny, Battersby, Cheryl, Clark, Katherine, Green, Marcus, Hunter, Rachael M., Shennan, Andrew H., Chappell, Lucy C., and Webster, Louise

Abstract

Additional file 1. Participant information leaflet

Published
2022
Full Text
View/download PDF

45. Additional file 3 of Placental growth fActor Repeat sampling for Reduction of adverse perinatal Outcomes in women with suspecTed pre-eclampsia: study protocol for a randomised controlled trial (PARROT-2)

Author

Hurrell, Alice, Sparkes, Jenie, Duhig, Kate, Seed, Paul T., Myers, Jenny, Battersby, Cheryl, Clark, Katherine, Green, Marcus, Hunter, Rachael M., Shennan, Andrew H., Chappell, Lucy C., and Webster, Louise

Abstract

Additional file 3. Management algorithm

Published
2022
Full Text
View/download PDF

49. Planned delivery to improve postpartum cardiac function in women with preterm pre-eclampsia: the PHOEBE mechanisms of action study within the PHOENIX RCT

Author

McCarthy, Fergus P, primary, O’Driscoll, Jamie, additional, Seed, Paul, additional, Brockbank, Anna, additional, Cox, Alice, additional, Gill, Carolyn, additional, Green, Marcus, additional, Marber, Mike, additional, Poston, Lucilla, additional, Placzek, Anna, additional, Shennan, Andrew, additional, Sparkes, Jenie, additional, Leeson, Paul, additional, Thilaganathan, Basky, additional, and Chappell, Lucy C, additional

Published
2021
Full Text
View/download PDF

50. Effect of Self-monitoring of Blood Pressure on Blood Pressure Control in Pregnant Individuals With Chronic or Gestational Hypertension

Author

Chappell, Lucy C., Tucker, Katherine L., Galal, Ushma, Yu, Ly-mee, Campbell, Helen, Rivero-arias, Oliver, Allen, Julie, Band, Rebecca, Chisholm, Alison, Crawford, Carole, Dougall, Greig, Engonidou, Lazarina, Franssen, Marloes, Green, Marcus, Greenfield, Sheila, Hinton, Lisa, Hodgkinson, James, Lavallee, Layla, Leeson, Paul, Mccourt, Christine, Mackillop, Lucy, Sandall, Jane, Santos, Mauro, Tarassenko, Lionel, Velardo, Carmelo, Wilson, Hannah, Yardley, Lucy, Mcmanus, Richard J., Cook, Johanna, Coates, Maria, Gabriel, Thomas, Brann, Stephanie, De Henau, Joris, Kelly, Sadie, Watt, Dave, Judge, David, Castello, Luis, Wishlade, Tabitha, Price, Helen, Fotaki, Eleni, Vowles, Zoe, Lewin, Alice, Tarft, Hayley, Wade, Julie, Symington, Declan, Hunt, Jessamine, Slaney, Maria, Mungeam, Charlotte, Khan, Rehan, Thomas, Amy, Newman, Tabitha, Gouldbourne, Melanie, Keen, Alexandra, Rossi, Alice, Maseko, Zandile, Churchill, David, Devison, Laura, Brooks, Kayleigh, Icke, Julia, Bose, Patrick, Lee, Fidelma, Scanlon, Suzanne, Girling, Joanna, Johnson, Mark, Singh, Natasha, Martella, Carmela, Adamson, Christine, Sogo Buaki, Maria, Beadle, Nikki, Hickey, Harriet, Iriondo-coysh, Amanda, Chilvers, Joanna, Duncan, Daisy, Bourke, Miriam, Myers, Jenny, Barry, Natalie, Glossop, Heather, Farrant, Kimberley, Waters, Clare, Thamban, Sujatha, Jones, Prudence, Felippe, Sophia, Kametas, Nick, Kay, Polly, Clark, Katherine, Jarman, Rebecca, Snowball, Olivia, Martin, Hayley, Osakwe, Osaeloke, Tilley, Bernadette, Barker, Any, Gonzalez, Raquel, Khalil, Asma, Robinson, Sophie, Canclini, Lisa, Unwin, Rebecca, Morris, Katie, Mellers, Dianne, Adams, Phern, Brittain, Lesley, Dann, Sohpie, O'hara, Chloe, Whitehouse, Diane, Ajay, Bini, Upson, Geraldine, O'donnell, Hannah, Zammit-mangion, Maria, Tebbutt, Julie, Frankland, Lisa, Thornton, Danielle, Sexton, Kristina, Crowe, Rebecca, Bowers, Amy, Winterbottom, Joanne, Yardley, L, and investigators, BUMP2

Subjects
Adult, Blood Pressure, Hypertension, Pregnancy-Induced, General Medicine, Blood Pressure Monitoring, Ambulatory, Telemedicine, Self-Testing, Pre-Eclampsia, Pregnancy, General & Internal Medicine, Chronic Disease, Hypertension, Humans, Female, 11 Medical and Health Sciences, Antihypertensive Agents, Original Investigation
Abstract

Importance Inadequate management of elevated blood pressure is a significant contributing factor to maternal deaths. The role of blood pressure self-monitoring in pregnancy in improving clinical outcomes for the pregnant individual and infant is unclear. Objective To evaluate the effect of blood pressure self-monitoring, compared with usual care alone, on blood pressure control and other related maternal and infant outcomes, in individuals with pregnancy hypertension. Design, Setting, and Participants Unblinded, randomized clinical trial that recruited between November 2018 and September 2019 in 15 hospital maternity units in England. Individuals with chronic hypertension (enrolled up to 37 weeks’ gestation) or with gestational hypertension (enrolled between 20 and 37 weeks’ gestation). Final follow-up was in May 2020. Interventions Participants were randomized to either blood pressure self-monitoring using a validated monitor and a secure telemonitoring system in addition to usual care (n = 430) or to usual care alone (n = 420). Usual care comprised blood pressure measured by health care professionals at regular antenatal clinics. Main Outcomes and Measures The primary maternal outcome was the difference in mean systolic blood pressure recorded by health care professionals between randomization and birth. Results Among 454 participants with chronic hypertension (mean age, 36 years; mean gestation at entry, 20 weeks) and 396 with gestational hypertension (mean age, 34 years; mean gestation at entry, 33 weeks) who were randomized, primary outcome data were available from 444 (97.8%) and 377 (95.2%), respectively. In the chronic hypertension cohort, there was no statistically significant difference in mean systolic blood pressure for the self-monitoring groups vs the usual care group (133.8 mm Hg vs 133.6 mm Hg, respectively; adjusted mean difference, 0.03 mm Hg [95% CI, −1.73 to 1.79]). In the gestational hypertension cohort, there was also no significant difference in mean systolic blood pressure (137.6 mm Hg compared with 137.2 mm Hg; adjusted mean difference, −0.03 mm Hg [95% CI, −2.29 to 2.24]). There were 8 serious adverse events in the self-monitoring group (4 in each cohort) and 3 in the usual care group (2 in the chronic hypertension cohort and 1 in the gestational hypertension cohort). Conclusions and Relevance Among pregnant individuals with chronic or gestational hypertension, blood pressure self-monitoring with telemonitoring, compared with usual care, did not lead to significantly improved clinic-based blood pressure control. Trial Registration ClinicalTrials.gov Identifier: NCT03334149

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results