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1. Aedes aegypti abundance and insecticide resistance profiles in the Applying Wolbachia to Eliminate Dengue trial

Author

Tantowijoyo, Warsito, primary, Tanamas, Stephanie K., additional, Nurhayati, Indah, additional, Setyawan, Sigit, additional, Budiwati, Nida, additional, Fitriana, Iva, additional, Ernesia, Inggrid, additional, Wardana, Dwi Satria, additional, Supriyati, Endah, additional, Arguni, Eggi, additional, Meitika, Yeti, additional, Prabowo, Equatori, additional, Andari, Bekti, additional, Green, Benjamin R., additional, Hodgson, Lauren, additional, Rancès, Edwige, additional, Ryan, Peter A., additional, O’Neill, Scott L., additional, Anders, Katherine L., additional, Ansari, M. Ridwan, additional, Indriani, Citra, additional, Ahmad, Riris Andono, additional, Utarini, Adi, additional, and Simmons, Cameron P., additional

Published
2022
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3. Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil

Author

Gesto, João Silveira Moledo, primary, Pinto, Sofia B., additional, Dias, Fernando Braga Stehling, additional, Peixoto, Julia, additional, Costa, Guilherme, additional, Kutcher, Simon, additional, Montgomery, Jacqui, additional, Green, Benjamin R., additional, Anders, Katherine L., additional, Ryan, Peter A., additional, Simmons, Cameron P., additional, O’Neill, Scott L., additional, and Moreira, Luciano Andrade, additional

Published
2021
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4. Effectiveness of Wolbachia-infected mosquito deployments in reducing the incidence of dengue and other Aedes-borne diseases in Niterói, Brazil: A quasi-experimental study

Author

Pinto, Sofia B., primary, Riback, Thais I. S., additional, Sylvestre, Gabriel, additional, Costa, Guilherme, additional, Peixoto, Julia, additional, Dias, Fernando B. S., additional, Tanamas, Stephanie K., additional, Simmons, Cameron P., additional, Dufault, Suzanne M., additional, Ryan, Peter A., additional, O’Neill, Scott L., additional, Muzzi, Frederico C., additional, Kutcher, Simon, additional, Montgomery, Jacqui, additional, Green, Benjamin R., additional, Smithyman, Ruth, additional, Eppinghaus, Ana, additional, Saraceni, Valeria, additional, Durovni, Betina, additional, Anders, Katherine L., additional, and Moreira, Luciano A., additional

Published
2021
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5. Efficacy of Wolbachia-Infected Mosquito Deployments for the Control of Dengue

Author

Utarini, Adi, primary, Indriani, Citra, additional, Ahmad, Riris A., additional, Tantowijoyo, Warsito, additional, Arguni, Eggi, additional, Ansari, M. Ridwan, additional, Supriyati, Endah, additional, Wardana, D. Satria, additional, Meitika, Yeti, additional, Ernesia, Inggrid, additional, Nurhayati, Indah, additional, Prabowo, Equatori, additional, Andari, Bekti, additional, Green, Benjamin R., additional, Hodgson, Lauren, additional, Cutcher, Zoe, additional, Rancès, Edwige, additional, Ryan, Peter A., additional, O’Neill, Scott L., additional, Dufault, Suzanne M., additional, Tanamas, Stephanie K., additional, Jewell, Nicholas P., additional, Anders, Katherine L., additional, and Simmons, Cameron P., additional

Published
2021
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7. Large-scale deployment and establishment of Wolbachia into the Aedes aegypti population in Rio de Janeiro, Brazil

Author

Moledo Gesto, João Silveira, primary, Pinto, Sofia, additional, Stehling Dias, Fernando Braga, additional, Peixoto, Julia, additional, Costa, Guilherme, additional, Kutcher, Simon, additional, Montgomery, Jacqui, additional, Green, Benjamin R., additional, Anders, Katherine L., additional, Ryan, Peter A., additional, Simmons, Cameron P., additional, O’Neill, Scott L., additional, and Moreira, Luciano Andrade, additional

Published
2021
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8. Effectiveness ofWolbachia-infected mosquito deployments in reducing the incidence of dengue and otherAedes-borne diseases in Niterói, Brazil: a quasi-experimental study

Author

Pinto, Sofia B., primary, Riback, Thais I. S., additional, Sylvestre, Gabriel, additional, Costa, Guilherme, additional, Peixoto, Julia, additional, Dias, Fernando B. S., additional, Tanamas, Stephanie K., additional, Simmons, Cameron P., additional, Dufault, Suzanne M., additional, Ryan, Peter A., additional, O’Neill, Scott L., additional, Muzzi, Frederico C., additional, Kutcher, Simon, additional, Montgomery, Jacqui, additional, Green, Benjamin R., additional, Smithyman, Ruth, additional, Eppinghaus, Ana, additional, Saraceni, Valeria, additional, Durovni, Betina, additional, Anders, Katherine L., additional, and Moreira, Luciano A., additional

Published
2021
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9. Reduced dengue incidence following deployments of Wolbachia-infected Aedes aegypti in Yogyakarta, Indonesia: a quasi-experimental trial using controlled interrupted time series analysis

Author

Indriani, Citra, primary, Tantowijoyo, Warsito, additional, Rancès, Edwige, additional, Andari, Bekti, additional, Prabowo, Equatori, additional, Yusdi, Dedik, additional, Ansari, Muhammad Ridwan, additional, Wardana, Dwi Satria, additional, Supriyati, Endah, additional, Nurhayati, Indah, additional, Ernesia, Inggrid, additional, Setyawan, Sigit, additional, Fitriana, Iva, additional, Arguni, Eggi, additional, Amelia, Yudiria, additional, Ahmad, Riris Andono, additional, Jewell, Nicholas P., additional, Dufault, Suzanne M., additional, Ryan, Peter A., additional, Green, Benjamin R., additional, McAdam, Thomas F., additional, O'Neill, Scott L., additional, Tanamas, Stephanie K., additional, Simmons, Cameron P., additional, Anders, Katherine L., additional, and Utarini, Adi, additional

Published
2020
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10. Reduced Dengue Incidence Following Deployments of Wolbachia-Infected Aedes aegypti in Yogyakarta, Indonesia

Author

Indriani, Citra, primary, Tantowijoyo, Warsito, additional, Rancès, Edwige, additional, Andari, Bekti, additional, Prabowo, Equatori, additional, Yusdi, Dedik, additional, Ansari, Muhammad Ridwan, additional, Wardhana, Dwi Satria, additional, Supriyati, Endah, additional, Nurhayati, Indah, additional, Ernesia, Inggrid, additional, Setyawan, Sigit, additional, Fitriana, Iva, additional, Arguni, Eggi, additional, Amelia, Yudiria, additional, Ahmad, Riris Andono, additional, Jewell, Nicholas P., additional, Dufault, Suzanne M., additional, Ryan, Peter A., additional, Green, Benjamin R., additional, McAdam, Thomas F., additional, O’Neill, Scott L., additional, Tanamas, Stephanie K., additional, Simmons, Cameron P., additional, Anders, Katherine, additional, and Utarini, Adi, additional

Published
2020
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13. Mechanism of Aortic Medial Matrix Remodeling is Distinct in Bicuspid Aortic Valve Patients

Author

Phillippi, Julie A., Green, Benjamin R., Eskay, Michael A., Kotlarczyk, Mary P., Hill, Michael R., Robertson, Anne M., Watkins, Simon C., Vorp, David A., and Gleason, Thomas G.

Subjects
Adult, Male, Aortic Diseases, Heart Valve Diseases, Aorta, Thoracic, Middle Aged, Article, Elastin, Protein-Lysine 6-Oxidase, Bicuspid Aortic Valve Disease, Matrix Metalloproteinase 9, Aortic Valve, Humans, Matrix Metalloproteinase 2, Female, Collagen, Tunica Media, Biomarkers, Aged
Abstract

Patients with bicuspid aortic valves (BAV) are predisposed to developing ascending thoracic aortic aneurysms (TAA) at an earlier age than patients who develop degenerative TAAs and have a tricuspid aortic valve (TAV). The hypothesis tested is that BAV-associated aortopathy is mediated by a mechanism of matrix remodeling that is distinct from that seen in TAAs of patients with tricuspid aortic valves.Aortic specimens were collected during ascending aortic replacement, aortic valve replacement, and heart transplants from nonaneurysmal (NA) donors and recipients. Matrix architecture of the aortic media was assessed qualitatively using multiphoton microscopy followed by quantification of collagen and elastin fiber orientation. α-Elastin was determined and matrix maturity was assessed by quantifying immature and mature collagen and lysyl oxidase (Lox) expression and activity in aortic specimens. Matrix metalloproteinase-2/9 activity was quantified in aortic smooth muscle cells.Elastin and collagen fibers were more highly aligned in BAV-NA and BAV-TAA cases than in TAV-TAA cases, whereas TAV-TAA cases were more disorganized than TAV-NA cases. α-Elastin content was unchanged. Immature collagen was reduced in BAV-NA and BAV-TAA cases when compared with TAV-NA and TAV-TAA cases. Mature collagen was elevated in TAV-TAA cases compared with TAV-NA and BAV-TAA cases. There was a trend toward elevated Lox gene expression and activity and matrix metalloproteinase-2/9 activity for TAV-TAA, BAV-NA, and BAV-TAA specimens.The highly aligned matrix architecture in patients with BAVs indicates that wall remodeling is distinct from TAV-TAA. Altered matrix architecture and reduced collagen maturity suggest that the effector molecules mediating the remodeling of TAAs are different in BAV and TAV cases.

Published
2013

15. Reactive oxygen species and zinc mediate BAV aortopathy

Author

Phillippi, Julie A., primary, Green, Benjamin R., additional, Eskay, Michael A., additional, Kotlarczyk, Mary P., additional, Hill, Michael R., additional, Robertson, Anne M., additional, Gibson, Gregory A., additional, Hong, Yi, additional, Wagner, William R., additional, Croix, Claudette M. St., additional, Watkins, Simon C., additional, Vorp, David A., additional, and Gleason, Thomas G., additional

Published
2013
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17. Mrp2 is involved in the efflux and disposition of fosinopril.

Author

Green, Benjamin R. and Bain, Lisa J.

Subjects
MULTIDRUG resistance-associated proteins, FOSINOPRIL, CELL transplantation, ANGIOTENSINS, ENZYME inhibitors, METHOTREXATE, DRUG interactions
Abstract

ABSTRACT The multidrug-resistance-associated proteins 1 and 2 (MRP1/MRP2) are transporters responsible for the efflux of drugs and endogenous compounds. Madin Darby canine kidney (MDCK) cells transfected with the human MRP1 or MRP2 genes were used to assess whether several widely used pharmaceuticals are potential substrates by examining their differential toxicity, accumulation and efflux. Loratadine, an antihistamine, was 1.4-fold less toxic to MRP1 cells and its retention was 1.3-fold lower than that from MDCK control cells. Fosinopril, an angiotensin converting enzyme inhibitor, was 2.4-fold less toxic and its retention was 4.5-fold lower in MRP2-transfected cells compared with control cells. To determine whether fosinopril contributed to a drug-drug interaction, fosinopril efflux was examined in vitro in combination with other known or suspected MRP2 substrates over a period of 20 min. When fosinopril was coincubated with desloratadine, loratadine or methotrexate, its retention was increased by 2-, 4.7- and 2-fold, respectively, which likely indicates that a drug-drug interaction is occurring. In vivo studies were conducted, in which FVB wild-type and FVB/ Mrp2−/− mice were dosed with fosinopril and the known MRP2 substrate methotrexate, and tissues collected after 1 h. In mice lacking Mrp2, drug levels were reduced in the intestine by 1.5-fold, but increased in the liver, serum and kidneys, by 2.1-, 2.9- and 3-fold, respectively. These data suggest that, in the absence of Mrp2, fosinopril alters the retention of a second drug. These findings will help increase our understanding of the role that MRP2 plays in altering the retention and disposition of coadministered pharmaceuticals. Copyright © 2011 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2013
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18. Large-scale releases and establishment of wMel Wolbachia in Aedes aegypti mosquitoes throughout the Cities of Bello, Medellín and Itagüí, Colombia.

Author

Velez ID, Uribe A, Barajas J, Uribe S, Ángel S, Suaza-Vasco JD, Mejia Torres MC, Arbeláez MP, Santacruz-Sanmartin E, Duque L, Martínez L, Posada T, Patiño AC, Gonzalez SM, Velez AL, Ramírez J, Salazar M, Gómez S, Osorio JE, Iturbe-Ormaetxe I, Dong Y, Muzzi FC, Rances E, Johnson PH, Smithyman R, Col B, Green BR, Frossard T, Brown-Kenyon J, Joubert DA, Grisales N, Ritchie SA, Denton JA, Gilles JRL, Anders KL, Kutcher SC, Ryan PA, and O'Neill SL

Subjects
Animals, Humans, Cities, Colombia, Environment, Mosquito Vectors, Aedes, Wolbachia
Abstract

Background: The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and has been shown to reduce the transmission of dengue and other Aedes-borne viruses. Here we report the entomological results from phased, large-scale releases of Wolbachia infected Ae. aegypti mosquitoes throughout three contiguous cities located in the Aburrá Valley, Colombia., Methodology/principal Findings: Local wMel Wolbachia-infected Ae. aegypti mosquitoes were generated and then released in an initial release pilot area in 2015-2016, which resulted in the establishment of Wolbachia in the local mosquito populations. Subsequent large-scale releases, mainly involving vehicle-based releases of adult mosquitoes along publicly accessible roads and streets, were undertaken across 29 comunas throughout Bello, Medellín and Itagüí Colombia between 2017-2022. In 9 comunas these were supplemented by egg releases that were undertaken by staff or community members. By the most recent monitoring, Wolbachia was found to be stable and established at consistent levels in local mosquito populations (>60% prevalence) in the majority (67%) of areas., Conclusion: These results, from the largest contiguous releases of wMel Wolbachia mosquitoes to date, highlight the operational feasibility of implementing the method in large urban settings. Based on results from previous studies, we expect that Wolbachia establishment will be sustained long term. Ongoing monitoring will confirm Wolbachia persistence in local mosquito populations and track its establishment in the remaining areas., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Velez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Published
2023
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