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1. Italian guidelines for the management of irritable bowel syndrome in children and adolescents: Joint Consensus from the Italian Societies of: Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP), Pediatrics (SIP), Gastroenterology and Endoscopy (SIGE) and Neurogastroenterology and Motility (SINGEM)

Author

Di Nardo, Giovanni, Barbara, Giovanni, Borrelli, Osvaldo, Cremon, Cesare, Giorgio, Valentina, Greco, Luigi, La Pietra, Michele, Marasco, Giovanni, Pensabene, Licia, Piccirillo, Marisa, Romano, Claudio, Salvatore, Silvia, Saviano, Michele, Stanghellini, Vincenzo, Strisciuglio, Caterina, Tambucci, Renato, Turco, Rossella, Zenzeri, Letizia, and Staiano, Annamaria

Published
2024
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4. List of contributors

Author

Aimo, Cristina, primary, Aronico, Nicola, additional, Auricchio, Renata, additional, Barone, Michele, additional, Biagi, Federico, additional, Bianchi, Paola Ilaria, additional, Bibbò, Stefano, additional, Broglio, Giacomo, additional, Caio, Giacomo, additional, Calabrese, Emma, additional, Cammarota, Giovanni, additional, Caproni, Marzia, additional, Carroccio, Antonio, additional, Castellaneta, Stefania, additional, Catassi, Carlo, additional, Catassi, Giulia, additional, Ciacci, Carolina, additional, Ciccocioppo, Rachele, additional, Copparoni, Roberto, additional, Corazza, Gino Roberto, additional, Corrà, Alberto, additional, Cristofori, Fernanda, additional, Dargenio, Vanessa Nadia, additional, De Giorgio, Roberto, additional, De Lisi, Giuseppe, additional, De Micco, Ida, additional, Di Sabatino, Antonio, additional, Di Stasio, Luigia, additional, Di Stefano, Michele, additional, Discepolo, Valentina, additional, Fasano, Alessio, additional, Francavilla, Ruggiero, additional, Gasbarrini, Antonio, additional, Gasbarrini, Giovanni, additional, Gatti, Simona, additional, Gianfrani, Carmen, additional, Giuliano, Alessandra, additional, Greco, Luigi, additional, Guandalini, Stefano, additional, Ianiro, Gianluca, additional, Lenti, Marco Vincenzo, additional, Lionetti, Elena, additional, Lucioni, Marco, additional, Maimaris, Stiliano, additional, Mamone, Gianfranco, additional, Mandile, Roberta, additional, Mansueto, Pasquale, additional, Marafini, Irene, additional, Mariotti, Elena Biancamaria, additional, Mengoli, Caterina, additional, Monteleone, Giovanni, additional, Monteleone, Ivan, additional, Neuhold, Susanna, additional, Novellino, Luisa, additional, Pilo, Caterina, additional, Plutino, Giuseppe, additional, Sansotta, Naire, additional, Santacroce, Giovanni, additional, Schiepatti, Annalisa, additional, Seidita, Aurelio, additional, Silano, Marco, additional, Troncone, Edoardo, additional, Troncone, Riccardo, additional, Vanoli, Alessandro, additional, Vitale, Serena, additional, Volta, Umberto, additional, Zanini, Annalisa, additional, and Zingone, Fabiana, additional

Published
2024
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10. Noncoercive parabolic obstacle problems

Author

Farroni Fernando, Greco Luigi, Moscariello Gioconda, and Zecca Gabriella

Subjects
obstacle problems, parabolic equations, 35k55, 35k61, Analysis, QA299.6-433
Abstract

We prove an existence result for obstacle problems related to convection-diffusion parabolic equations with singular coefficients in the convective term. Our operator is not coercive, the obstacle function is time-dependent irregular, and the coefficients in the lower-order term belong to a borderline mixed Lebesgue-Marcinkiewicz space.

Published
2023
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11. Nonlinear evolution problems with singular coefficients in the lower order terms

Author

Farroni, Fernando, Greco, Luigi, Moscariello, Gioconda, and Zecca, Gabriella

Subjects
Mathematics - Analysis of PDEs, 35K55, 35K61
Abstract

We consider a Cauchy Dirichlet problem for a quasilinear second order parabolic equation with lower order term driven by a singular coefficient. We establish an existence result to such a problem and we describe the time behavior of the solution in the case of the infinite time horizon.

Published
2020

12. Noncoercive quasilinear elliptic operators with singular lower order terms

Author

Farroni, Fernando, Greco, Luigi, Moscariello, Gioconda, and Zecca, Gabriella

Subjects
Mathematics - Analysis of PDEs
Abstract

We consider a family of quasilinear second order elliptic differential operators which are not coercive and are defined by functions in Marcinkiewicz spaces. We prove the existence of a solution to the corresponding Dirichlet problem. The associated obstacle problem is also solved. Finally, we show higher integrability of a solution to the Dirichlet problem when the datum is more regular.

Published
2020

13. Diffeomorphic approximation of Planar Sobolev Homeomorphisms in rearrangement invariant spaces

Author

Campbell, Daniel, Greco, Luigi, Schiattarella, Roberta, and Soudsky, Filip

Subjects
Mathematics - Analysis of PDEs
Abstract

Let $\Omega\subseteq\mathcal{R}^2$ be a domain, let $X$ be a rearrangement invariant space and let $f\in W^{1}X(\Omega,\mathcal{R}^2)$ be a homeomorphism between $\Omega$ and $f(\Omega)$. Then there exists a sequence of diffeomorphisms $f_k$ converging to $f$ in the space $W^{1}X(\Omega,\mathcal{R}^2)$.

Published
2020

14. Atomic decompositions, two stars theorems, and distances for the Bourgain-Brezis-Mironescu space and other big spaces

Author

D'Onofrio, Luigi, Greco, Luigi, Perfekt, Karl-Mikael, Sbordone, Carlo, and Schiattarella, Roberta

Subjects
Mathematics - Functional Analysis
Abstract

Given a Banach space $E$ with a supremum-type norm induced by a collection of operators, we prove that $E$ is a dual space and provide an atomic decomposition of its predual. We apply this result, and some results obtained previously by one of the authors, to the function space $\mathcal{B}$ introduced recently by Bourgain, Brezis, and Mironescu. This yields an atomic decomposition of the predual $\mathcal{B}_\ast$, the biduality result that $\mathcal{B}_0^\ast = \mathcal{B}_\ast$ and $\mathcal{B}_\ast^\ast = \mathcal{B}$, and a formula for the distance from an element $f \in \mathcal{B}$ to $\mathcal{B}_0$.

Published
2019

15. Gluten consumption and inflammation affect the development of celiac disease in at-risk children

Author

Auricchio Renata, Calabrese Ilaria, Galatola Martina, Cielo Donatella, Carbone Fortunata, Mancuso Marianna, Matarese Giuseppe, Troncone Riccardo, Auricchio Salvatore, and Greco Luigi

Subjects
Medicine, Science
Abstract

Abstract Gene expression, lipidomic and growth impairment findings suggest that the natural history of celiac disease (CD) starts before the gluten-induced immune response. Gluten intake in the first years of life is a controversial risk factor. We aimed to estimate the risk of developing CD associated with the amount of gluten intake and the serum inflammatory profile in genetically predisposed infants. From an Italian cohort of children at risk for CD, we enrolled 27 children who developed CD (cases) and 56 controls matched by sex and age. A dietary interview at 9, 12, 18, 24 and 36 months was performed. Serum cytokines (INFγ, IL1β, IL2, IL4, IL6, IL10 IL12p70, IL17, and TNFα) were analysed at 4 and 36 months. Infants who developed CD by 6 years showed an increase in serum cytokines (INFγ, IL1β, IL2, IL6, IL10, IL12p70 and TNFα) at 4 months of age before gluten introduction. CD cases ate significantly more gluten in the second year of life than controls, and gluten intake in the second year of life was strongly correlated with serum cytokines (INFγ, IL2, IL4, IL12p70, IL17) at 36 months only in CD cases. The dietary pattern of infants who developed CD was characterized by high consumption of biscuits and fruit juices and low intake of milk products, legumes, vegetables and fruits. Genetically predisposed infants who developed CD showed a unique serum cytokine profile at 4 months before gluten consumption. The amount of gluten was strongly correlated with an inflammatory profile in serum cytokines at 36 months only in infants who developed CD.

Published
2022
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19. Estimates for $p$-Laplace type equation in a limit case

Author

Farroni, Fernando, Greco, Luigi, and Moscariello, Gioconda

Subjects
Mathematics - Analysis of PDEs
Abstract

We study some Dirichlet problem for a $p$--Laplacian type operator in the setting of Orlicz--Zygmund space $L^q\log^{-\alpha}L(\Omega,\mathbb R^N)$, $q >1$ and $\alpha>0$. More precisely, our aim is to establish which assuptions on the parameter $\alpha>0$ lead to existence, uniqueness of the solution and continuity of the associated nonlinear operator.

Published
2013

23. Potential Celiac Disease in Children: Health Status on A Long-Term Gluten-Containing Diet.

Author

Mandile, Roberta, Lerro, Federica, Carpinelli, Martina, D'Antonio, Lorenzo, Greco, Luigi, Troncone, Riccardo, and Auricchio, Renata

Abstract

Potential celiac disease (PCD) is a clinical condition characterised by the presence of a positive CD-specific serology and a normal intestinal architecture. Asymptomatic PCD patients are generally advised to continue on a gluten-containing diet (GCD), but long-term risks of this approach have never been explored. In the present study, we aimed to investigate nutritional and autoimmune complications possibly developing overtime in a cohort of asymptomatic PCD children on a GCD. We compared children's parameters of growth, nutritional status, and autoimmunity between the time of diagnosis and on the occasion of their last medical check, after a long-term gluten-containing diet. Altogether, we collected data from 171 PCD children with a mean follow-up time of 3 years (range 0.35–15.3 years). During follow-up, although patients did not reduce their amount of daily gluten intake, their anti-tissue transglutaminase (anti-TG2) antibodies spontaneously and significantly decreased. Most parameters analysed had not changed during follow-up (height centile, ferritin, albumin, cholesterol, calcium, alkaline phosphatase, parathormone, and vitamin D) or even improved significantly (weight and BMI centile, haemoglobin, blood iron, HDL, glycaemia, and HbA1C, p < 0.05), always remaining within the limit of normality. Equally, autoantibodies for other concomitant autoimmune disorders did not increase overtime. Similar results were obtained excluding from analysis patients who had stopped producing anti-TG2 and those with a follow-up time < 3 years. Our pilot study has provided reassuring results regarding the maintenance of a gluten-containing diet in asymptomatic PCD children, even when long-term follow-up was considered. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Multiple common variants for celiac disease influencing immune gene expression

Author

Dubois, Patrick CA, Trynka, Gosia, Franke, Lude, Hunt, Karen A, Romanos, Jihane, Curtotti, Alessandra, Zhernakova, Alexandra, Heap, Graham AR, Ádány, Róza, Aromaa, Arpo, Bardella, Maria Teresa, van den Berg, Leonard H, Bockett, Nicholas A, de la Concha, Emilio G, Dema, Bárbara, Fehrmann, Rudolf SN, Fernández-Arquero, Miguel, Fiatal, Szilvia, Grandone, Elvira, Green, Peter M, Groen, Harry JM, Gwilliam, Rhian, Houwen, Roderick HJ, Hunt, Sarah E, Kaukinen, Katri, Kelleher, Dermot, Korponay-Szabo, Ilma, Kurppa, Kalle, MacMathuna, Padraic, Mäki, Markku, Mazzilli, Maria Cristina, McCann, Owen T, Mearin, M Luisa, Mein, Charles A, Mirza, Muddassar M, Mistry, Vanisha, Mora, Barbara, Morley, Katherine I, Mulder, Chris J, Murray, Joseph A, Núñez, Concepción, Oosterom, Elvira, Ophoff, Roel A, Polanco, Isabel, Peltonen, Leena, Platteel, Mathieu, Rybak, Anna, Salomaa, Veikko, Schweizer, Joachim J, Sperandeo, Maria Pia, Tack, Greetje J, Turner, Graham, Veldink, Jan H, Verbeek, Wieke HM, Weersma, Rinse K, Wolters, Victorien M, Urcelay, Elena, Cukrowska, Bozena, Greco, Luigi, Neuhausen, Susan L, McManus, Ross, Barisani, Donatella, Deloukas, Panos, Barrett, Jeffrey C, Saavalainen, Paivi, Wijmenga, Cisca, and van Heel, David A

Subjects
Biotechnology, Human Genome, Genetics, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Case-Control Studies, Celiac Disease, Gene Expression, Gene Expression Profiling, Genes, MHC Class I, Genome-Wide Association Study, Humans, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Risk, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs from 14 known loci in a further 4,918 cases and 5,684 controls. Variants from 13 new regions reached genome-wide significance (P(combined) < 5 x 10(-8)); most contain genes with immune functions (BACH2, CCR4, CD80, CIITA-SOCS1-CLEC16A, ICOSLG and ZMIZ1), with ETS1, RUNX3, THEMIS and TNFRSF14 having key roles in thymic T-cell selection. There was evidence to suggest associations for a further 13 regions. In an expression quantitative trait meta-analysis of 1,469 whole blood samples, 20 of 38 (52.6%) tested loci had celiac risk variants correlated (P < 0.0028, FDR 5%) with cis gene expression.

Published
2010

29. Antibody Profile, Gene Expression and Serum Cytokines in At-Risk Infants before the Onset of Celiac Disease

Author

Auricchio, Renata, primary, Galatola, Martina, additional, Cielo, Donatella, additional, Rotondo, Roberta, additional, Carbone, Fortunata, additional, Mandile, Roberta, additional, Carpinelli, Martina, additional, Vitale, Serena, additional, Matarese, Giuseppe, additional, Gianfrani, Carmen, additional, Troncone, Riccardo, additional, Auricchio, Salvatore, additional, and Greco, Luigi, additional

Published
2023
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30. Higher order phase-field modeling of brittle fracture viaisogeometric analysis

Author

Greco, Luigi, Patton, Alessia, Negri, Matteo, Marengo, Alessandro, Perego, Umberto, and Reali, Alessandro

Abstract

The evolution of brittle fracture in a material can be conveniently investigated by means of the phase-field technique introducing a smooth crack density functional. Following Borden et al. (2014), two distinct types of phase-field functional are considered: (i) a second-order model and (ii) a fourth-order one. The latter approach involves the bi-Laplacian of the phase field and therefore the resulting Galerkin form requires continuously differentiable basis functions: a condition we easily fulfill viaIsogeometric Analysis. In this work, we provide an extensive comparison of the considered formulations performing several tests that progressively increase the complexity of the crack patterns. To measure the fracture length necessary in our accuracy evaluations, we propose an image-based algorithm that features an automatic skeletonization technique able to track complex fracture patterns. In all numerical results, damage irreversibility is handled in a straightforward and rigorous manner using the Projected Successive Over-Relaxation algorithm that is suitable to be adopted for both phase-field formulations since it can be used in combination with higher continuity isogeometric discretizations. Based on our results, the fourth-order approach provides higher rates of convergence and a greater accuracy. Moreover, we observe that fourth- and second-order models exhibit a comparable accuracy when the former methods employ a mesh-size approximately two times larger, entailing a substantial reduction of the computational effort.

Published
2024
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34. Effects of Major Abdominal Surgery on Red Blood Cell Deformability

Author

Greco, Luigi, Gentile, Antonella, Panzera, Piercarmine, Catalano, Giorgio, Cicco, Giuseppe, Memeo, Vincenzo, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Cicco, Giuseppe, editor, Bruley, Duane F., editor, Ferrari, Marco, editor, and Harrison, David K., editor

Published
2006
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35. Effects of Preservation Solutions on Blood

Author

Panzera, Piercarmine, Greco, Luigi, Rotelli, Maria T., Lavolpe, Vito, Salerno, Anna M., Gentile, Antonella, Catalano, Giorgio, Cicco, Giuseppe, Memeo, Vincenzo, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Cicco, Giuseppe, editor, Bruley, Duane F., editor, Ferrari, Marco, editor, and Harrison, David K., editor

Published
2006
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36. Post Ischemic No-Reflow after 60 Minutes Hepatic Warm Ischemia in Pigs

Author

Greco, Luigi, Gentile, Antonella, Panzera, Piercarmine, Catalano, Giorgio, Cicco, Giuseppe, Memeo, Vincenzo, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Cicco, Giuseppe, editor, Bruley, Duane F., editor, Ferrari, Marco, editor, and Harrison, David K., editor

Published
2006
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37. Alteration of Brain Oxygenation During 'Piggy Back' Liver Transplantation

Author

Panzera, Piercarmine, Greco, Luigi, Carravetta, Giuseppe, Gentile, Antonella, Catalano, Giorgio, Cicco, Giuseppe, Memeo, Vincenzo, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Cicco, Giuseppe, editor, Bruley, Duane F., editor, Ferrari, Marco, editor, and Harrison, David K., editor

Published
2006
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38. Gluten consumption and inflammation affect the development of celiac disease in at-risk children

Author

Auricchio, Renata, Calabrese, Ilaria, Galatola, Martina, Cielo, Donatella, Carbone, Fortunata, Mancuso, Marianna, Matarese, Giuseppe, Troncone, Riccardo, Auricchio, Salvatore, Greco, Luigi, Auricchio, Renata, Calabrese, Ilaria, Galatola, Martina, Cielo, Donatella, Carbone, Fortunata, Mancuso, Marianna, Matarese, Giuseppe, Troncone, Riccardo, Auricchio, Salvatore, and Greco, Luigi

Subjects
Inflammation, Celiac Disease, Multidisciplinary, Glutens, Child, Preschool, Humans, Infant, Child, Interleukin-12, Diet
Abstract

Gene expression, lipidomic and growth impairment findings suggest that the natural history of celiac disease (CD) starts before the gluten-induced immune response. Gluten intake in the first years of life is a controversial risk factor. We aimed to estimate the risk of developing CD associated with the amount of gluten intake and the serum inflammatory profile in genetically predisposed infants. From an Italian cohort of children at risk for CD, we enrolled 27 children who developed CD (cases) and 56 controls matched by sex and age. A dietary interview at 9, 12, 18, 24 and 36 months was performed. Serum cytokines (INFγ, IL1β, IL2, IL4, IL6, IL10 IL12p70, IL17, and TNFα) were analysed at 4 and 36 months. Infants who developed CD by 6 years showed an increase in serum cytokines (INFγ, IL1β, IL2, IL6, IL10, IL12p70 and TNFα) at 4 months of age before gluten introduction. CD cases ate significantly more gluten in the second year of life than controls, and gluten intake in the second year of life was strongly correlated with serum cytokines (INFγ, IL2, IL4, IL12p70, IL17) at 36 months only in CD cases. The dietary pattern of infants who developed CD was characterized by high consumption of biscuits and fruit juices and low intake of milk products, legumes, vegetables and fruits. Genetically predisposed infants who developed CD showed a unique serum cytokine profile at 4 months before gluten consumption. The amount of gluten was strongly correlated with an inflammatory profile in serum cytokines at 36 months only in infants who developed CD.

Published
2021

44. Natural History of Potential Celiac Disease in Children

Author

Tosco, Antonella, Salvati, Virginia Michela, Auricchio, Renata, Maglio, Mariantonia, Borrelli, Melissa, Coruzzo, Anna, Paparo, Francesco, Boffardi, Massimo, Esposito, Antonella, D'Adamo, Grazia, Malamisura, Basilio, Greco, Luigi, and Troncone, Riccardo

Published
2011
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