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723 results on '"Greco, Carlo"'

2. Field Output correction factors of small static field for IBA Razor NanoChamber

Author

Mateus, Dalila, Greco, Carlo, and Peralta, Luis

Subjects
Physics - Medical Physics, Physics - Instrumentation and Detectors
Abstract

The goal of this work is to present results of field output factors (OF) using an IBA CC003 (Razor NanoChamber) and compared these results with PTW 60019 (MicroDiamond) and IBA Razor Diode. The experimental results for IBA CC003 were also compared with Monte Carlo (MC) Simulation, using Penelope and Ulysses programs. In addition, field output correction factors for IBA CC003 were derived with three different methods: 1) using PTW 60019 and IBA Razor as reference detectors; 2) comparison between MC and experimental measurements; and 3) using only MC. The beam collimation included in this study were 1) square field size between 10x10 and 0.5x0.5 cm2 defined by the MLC and jaws and 2) cones of different diameters. For IBA CC003 it was determined the polarity and ion collection efficiency correction factors in parallel and perpendicular orientation. The results indicate 1) the variation of polarity effect with the field size is relevant for the determination of OF using IBA CC003, especially for parallel orientation; 2) there is no significant variation of the ion collection efficiency with the field size using IBA CC003 in parallel orientation; 3) OF differences between IBA CC003 and PTW 60019/IBA Razor and experimental and MC results increase with decreasing field size. Results on the field output correction factor indicate 1) using the first and second method, the factor increase with decreasing field size, which can be related with the influence of the volume effect and 2) using the third method the factor decrease with decreasing field size, which can be explained by the perturbation effect., Comment: 23 pages, 10 figures, 11 tables

Published
2023

3. Clinical implications of the family history in patients with lung cancer: a systematic review of the literature and a new cross-sectional/prospective study design (FAHIC: lung)

Author

Citarella, Fabrizio, Takada, Kazuki, Cascetta, Priscilla, Crucitti, Pierfilippo, Petti, Roberta, Vincenzi, Bruno, Tonini, Giuseppe, Venanzi, Francesco M., Bulotta, Alessandra, Oresti, Sara, Greco, Carlo, Ramella, Sara, Crinò, Lucio, Delmonte, Angelo, Ferrara, Roberto, Di Maio, Massimo, Gurrieri, Fiorella, and Cortellini, Alessio

Published
2024
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4. An Innovative Indoor and Controlled Sustainable Snail Breeding System

Author

Greco, Carlo, Catania, Pietro, Orlando, Santo, Vallone, Mariangela, Mammano, Michele Massimo, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Berruto, Remigio, editor, Biocca, Marcello, editor, Cavallo, Eugenio, editor, Cecchini, Massimo, editor, Failla, Sabina, editor, and Romano, Elio, editor

Published
2024
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5. Assessment of Vegetation Indices as Tool to Decision Support System for Aromatic Crops

Author

Greco, Carlo, Catania, Pietro, Orlando, Santo, Vallone, Mariangela, Mammano, Michele Massimo, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Berruto, Remigio, editor, Biocca, Marcello, editor, Cavallo, Eugenio, editor, Cecchini, Massimo, editor, Failla, Sabina, editor, and Romano, Elio, editor

Published
2024
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6. Whole Body Vibration Transmission to the Human Rachis in Agricultural Tractors

Author

Orlando, Salvatore, Greco, Carlo, Catania, Pietro, Vallone, Mariangela, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Berruto, Remigio, editor, Biocca, Marcello, editor, Cavallo, Eugenio, editor, Cecchini, Massimo, editor, Failla, Sabina, editor, and Romano, Elio, editor

Published
2024
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13. A Prototype of Photovoltaic Dryer for Nutraceutical and Aromatic Plants

Author

Mammano, Michele Massimo, Comparetti, Antonio, Ciulla, Salvatore, Greco, Carlo, Orlando, Santo, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Ferro, Vito, editor, Giordano, Giuseppe, editor, Orlando, Santo, editor, Vallone, Mariangela, editor, Cascone, Giovanni, editor, and Porto, Simona M. C., editor

Published
2023
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14. A Model of Sicilian Environmentally Friendly Multifunctional Farm for Soil Protection

Author

Mammano, Michele Massimo, Comparetti, Antonio, Greco, Carlo, Orlando, Santo, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Ferro, Vito, editor, Giordano, Giuseppe, editor, Orlando, Santo, editor, Vallone, Mariangela, editor, Cascone, Giovanni, editor, and Porto, Simona M. C., editor

Published
2023
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15. Development of an Investment Decision Tool for Biogas Production from Biowaste in Mediterranean Islands

Author

Asciuto, Antonio, Agosta, Martina, Attard, George, Comparetti, Antonio, Greco, Carlo, Mammano, Michele Massimo, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Ferro, Vito, editor, Giordano, Giuseppe, editor, Orlando, Santo, editor, Vallone, Mariangela, editor, Cascone, Giovanni, editor, and Porto, Simona M. C., editor

Published
2023
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16. Potential Bioenergy and Biofertiliser Production from Livestock Waste in Mediterranean Islands Within Circular Bioeconomy

Author

Attard, George, Azzopardi, Noel, Comparetti, Antonio, Greco, Carlo, Gruppetta, Anthony, Orlando, Santo, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Ferro, Vito, editor, Giordano, Giuseppe, editor, Orlando, Santo, editor, Vallone, Mariangela, editor, Cascone, Giovanni, editor, and Porto, Simona M. C., editor

Published
2023
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18. Phase 3 Multi-Center, Prospective, Randomized Trial Comparing Single-Dose 24 Gy Radiation Therapy to a 3-Fraction SBRT Regimen in the Treatment of Oligometastatic Cancer

Author

Zelefsky, Michael J, Yamada, Yoshiya, Greco, Carlo, Lis, Eric, Schöder, Heiko, Lobaugh, Stephanie, Zhang, Zhigang, Braunstein, Steve, Bilsky, Mark H, Powell, Simon N, Kolesnick, Richard, and Fuks, Zvi

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Clinical Research, Clinical Trials and Supportive Activities, Biomedical Imaging, Adult, Aged, Humans, Male, Middle Aged, Neoplasm Metastasis, Neoplasms, Radiation Dosage, Radiosurgery, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Other Physical Sciences, Oncology & Carcinogenesis, Oncology and carcinogenesis, Theoretical and computational chemistry, Medical and biological physics
Abstract

PurposeThis prospective phase 3 randomized trial was designed to test whether ultra high single-dose radiation therapy (24 Gy SDRT) improves local control of oligometastatic lesions compared to a standard hypofractionated stereotactic body radiation therapy regimen (3 × 9 Gy SBRT). The secondary endpoint was to assess the associated toxicity and the impact of ablation on clinical patterns of metastatic progression.Methods and materialsBetween November 2010 and September 2015, 117 patients with 154 oligometastatic lesions (≤5/patient) were randomized in a 1:1 ratio to receive 24 Gy SDRT or 3 × 9 Gy SBRT. Local control within the irradiated field and the state of metastatic spread were assessed by periodic whole-body positron emission tomography/computed tomography and/or magnetic resonance imaging. Median follow-up was 52 months.ResultsA total of 59 patients with 77 lesions were randomized to 24 Gy SDRT and 58 patients with 77 lesions to 3 × 9 Gy SBRT. The cumulative incidence of local recurrence for SDRT-treated lesions was 2.7% (95% confidence interval [CI], 0%-6.5%) and 5.8% (95% CI, 0.2%-11.5%) at years 2 and 3, respectively, compared with 9.1% (95% CI, 2.6%-15.6%) and 22% (95% CI, 11.9%-32.1%) for SBRT-treated lesions (P = .0048). The 2- and 3-year cumulative incidences of distant metastatic progression in the SDRT patients were 5.3% (95% CI, 0%-11.1%), compared with 10.7% (95% CI, 2.5%-18.8%) and 22.5% (95% CI, 11.1%-33.9%), respectively, for the SBRT patients (P = .010). No differences in toxicity were observed.ConclusionsThe study confirms SDRT as a superior ablative treatment, indicating that effective ablation of oligometastatic lesions is associated with significant mitigation of distant metastatic progression.

Published
2021

22. New options and open issues in the management of unresectable stage III and in early-stage NSCLC: A report from an expert panel of Italian medical and radiation oncologists – INTERACTION group

Author

Catania, Chiara, Filippi, Andrea Riccardo, Sangalli, Claudia, Piperno, Gaia, Russano, Marco, Greco, Carlo, Scotti, Vieri, Proto, Claudia, Bennati, Chiara, Di Pietro Paolo, Marzia, Platania, Angelo, Olmetto, Emanuela, Agustoni, Francesco, Teodorani, Nazario, Agbaje, Vincenzo, and Russo, Alessandro

Published
2023
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24. A Contribution to Environmental Protection Through the Valorisation of Kitchen Biowaste

Author

Greco, Carlo, Comparetti, Antonio, Orlando, Santo, Mammano, Michele Massimo, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Biocca, Marcello, editor, Cavallo, Eugenio, editor, Cecchini, Massimo, editor, Failla, Sabina, editor, and Romano, Elio, editor

Published
2022
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26. Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury

Author

Bodo, Sahra, Campagne, Cécile, Thin, Tin Htwe, Higginson, Daniel S, Vargas, H Alberto, Hua, Guoqiang, Fuller, John D, Ackerstaff, Ellen, Russell, James, Zhang, Zhigang, Klingler, Stefan, Cho, HyungJoon, Kaag, Matthew G, Mazaheri, Yousef, Rimner, Andreas, Manova-Todorova, Katia, Epel, Boris, Zatcky, Joan, Cleary, Cristian R, Rao, Shyam S, Yamada, Yoshiya, Zelefsky, Michael J, Halpern, Howard J, Koutcher, Jason A, Cordon-Cardo, Carlos, Greco, Carlo, Haimovitz-Friedman, Adriana, Sala, Evis, Powell, Simon N, Kolesnick, Richard, and Fuks, Zvi

Subjects
Genetics, Cancer, Animals, Cell Line, Tumor, Chromatin, Homologous Recombination, Humans, Mice, Neoplasm Proteins, Neoplasms, Reperfusion Injury, Signal Transduction, Small Ubiquitin-Related Modifier Proteins, Ubiquitins, DNA repair, Oncology, Vascular Biology, Medical and Health Sciences, Immunology
Abstract

Tumor cure with conventional fractionated radiotherapy is 65%, dependent on tumor cell-autonomous gradual buildup of DNA double-strand break (DSB) misrepair. Here we report that single-dose radiotherapy (SDRT), a disruptive technique that ablates more than 90% of human cancers, operates a distinct dual-target mechanism, linking acid sphingomyelinase-mediated (ASMase-mediated) microvascular perfusion defects to DNA unrepair in tumor cells to confer tumor cell lethality. ASMase-mediated microcirculatory vasoconstriction after SDRT conferred an ischemic stress response within parenchymal tumor cells, with ROS triggering the evolutionarily conserved SUMO stress response, specifically depleting chromatin-associated free SUMO3. Whereas SUMO3, but not SUMO2, was indispensable for homology-directed repair (HDR) of DSBs, HDR loss of function after SDRT yielded DSB unrepair, chromosomal aberrations, and tumor clonogen demise. Vasoconstriction blockade with the endothelin-1 inhibitor BQ-123, or ROS scavenging after SDRT using peroxiredoxin-6 overexpression or the SOD mimetic tempol, prevented chromatin SUMO3 depletion, HDR loss of function, and SDRT tumor ablation. We also provide evidence of mouse-to-human translation of this biology in a randomized clinical trial, showing that 24 Gy SDRT, but not 3×9 Gy fractionation, coupled early tumor ischemia/reperfusion to human cancer ablation. The SDRT biology provides opportunities for mechanism-based selective tumor radiosensitization via accessing of SDRT/ASMase signaling, as current studies indicate that this pathway is tractable to pharmacologic intervention.

Published
2019

29. Effect of the gellan-based edible coating enriched with oregano essential oil on the preservation of the ‘Tardivo di Ciaculli’ mandarin (Citrus reticulata Blanco cv. Tardivo di Ciaculli)

Author

Liguori, Giorgia, primary, Greco, Giuseppe, additional, Salsi, Giulia, additional, Garofalo, Giuliana, additional, Gaglio, Raimondo, additional, Barbera, Marcella, additional, Greco, Carlo, additional, Orlando, Santo, additional, Fascella, Giancarlo, additional, and Mammano, Michele Massimo, additional

Published
2024
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30. The NIPRO Study: An Observational, Retrospective, Multicenter Study on the Safety of the Radiotherapy and Immunotherapy Combination for Advanced-Stage NSCLC

Author

Perna, Marco, Scotti, Vieri, Ciammella, Patrizia, Borghetti, Paolo, D'angelo, Elisa, Levra, Niccolò Giaj, Fozza, Alessandra, Mariotti, Matteo, Salvestrini, Viola, Bertolini, Federica, Vagge, Stefano, Taraborrelli, Maria, Falcinelli, Lorenzo, Taddeo, Alessandra, Rossi, Roberto, Costantino, Gianluca, Frassinelli, Luca, Filippi, Andrea Riccardo, Greco, Carlo, Franceschini, Davide, Genovesi, Domenico, Lohr, Frank, Magrini, Stefano Maria, Alongi, Filippo, Livi, Lorenzo, and Bruni, Alessio

Published
2021
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39. Deep pathomics: A new image-based tool for predicting response to treatment in stage III non-small cell lung cancer

Author

Nibid, Lorenzo, primary, Greco, Carlo, additional, Cordelli, Ermanno, additional, Sabarese, Giovanna, additional, Fiore, Michele, additional, Liu, Charles Z., additional, Ippolito, Edy, additional, Sicilia, Rosa, additional, Miele, Marianna, additional, Tortora, Matteo, additional, Taffon, Chiara, additional, Rakaee, Mehrdad, additional, Soda, Paolo, additional, Ramella, Sara, additional, and Perrone, Giuseppe, additional

Published
2023
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46. Combination of novel systemic agents and radiotherapy for solid tumors – part I: An AIRO (Italian association of radiotherapy and clinical oncology) overview focused on treatment efficacy

Author

Arcangeli, Stefano, Jereczek-Fossa, Barbara Alicia, Alongi, Filippo, Aristei, Cynthia, Becherini, Carlotta, Belgioia, Liliana, Buglione, Michela, Caravatta, Luciana, D’Angelillo, Rolando Maria, Filippi, Andrea Riccardo, Fiore, Michele, Genovesi, Domenico, Greco, Carlo, Livi, Lorenzo, Magrini, Stefano Maria, Marvaso, Giulia, Mazzola, Rosario, Meattini, Icro, Merlotti, Anna, Palumbo, Isabella, Pergolizzi, Stefano, Ramella, Sara, Ricardi, Umberto, Russi, Elvio, Trovò, Marco, Sindoni, Alessandro, Valentini, Vincenzo, and Corvò, Renzo

Published
2019
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47. Combination of novel systemic agents and radiotherapy for solid tumors – Part II: An AIRO (Italian association of radiotherapy and clinical oncology) overview focused on treatment toxicity

Author

Arcangeli, Stefano, Jereczek-Fossa, Barbara Alicia, Alongi, Filippo, Aristei, Cynthia, Becherini, Carlotta, Belgioia, Liliana, Buglione, Michela, Caravatta, Luciana, D’Angelillo, Rolando Maria, Filippi, Andrea Riccardo, Fiore, Michele, Genovesi, Domenico, Greco, Carlo, Livi, Lorenzo, Magrini, Stefano Maria, Marvaso, Giulia, Mazzola, Rosario, Meattini, Icro, Merlotti, Anna, Palumbo, Isabella, Pergolizzi, Stefano, Ramella, Sara, Ricardi, Umberto, Russi, Elvio, Trovò, Marco, Sindoni, Alessandro, Valentini, Vincenzo, and Corvò, Renzo

Published
2019
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