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196 results on '"Greabu, Maria"'

1. Biomarkers of acute kidney injury: a concise review of current literature

Author

Văcăroiu Ileana Adela, Balcangiu-Stroescu Andra Elena, Șerban-Feier Larisa Florina, Cuiban Elena, Simion Ioana Sorina, Stănescu-Spînu Iulia Ioana, Miricescu Daniela, Greabu Maria, Chiperi Liviu Vasile, and Bălan Daniela Gabriela

Subjects
acute kidney injury (aki), biomarkers, cystatin c (cys-c), liver-type fatty acid-binding protein (l-fabp), neutrophil gelatinase-associated lipocalin (ngal), Medicine
Abstract

Acute kidney injury (AKI), a medical condition associated with increased hospitalization rates which requires interdisciplinary management, is a major health concern because of the burden it places on the health systems of different countries. Biomarkers represent the focus of recent years in furthering the early diagnosis of AKI, providing new opportunities for correct prophylaxis or early therapeutic intervention so that the evolution of patients with this pathology is favorable and the risk of life-threatening complications is negligible.

Published
2024
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2. The importance of the enzyme Gamma-glutamyltransferase in the pathogenic cluster in type2 diabetic patient

Author

Virgolici Bogdana, Dobre Maria Zinaida, Lixandru Daniela, Petcu Laura, Picu Ariana, Ionescu-Târgovişte Constantin, Greabu Maria, and Bacanu Elena Violeta

Subjects
alanine aminotransferase, chemoattractant protein 1, monocyte, gamma glutamyl transpeptidase, insulin resistance, intercellular adhesion molecule-1, oxidative stress, tumor necrosis factor-α, type 2 diabetes mellitus, Internal medicine, RC31-1245
Abstract

Introduction. Gamma-glutamyltransferase (GGT) is a liver enzyme involved in inflammation and oxidative stress. It is already known that MCP-1 (Monocyte Chemoattractant Protein-1) and TNF-α (tumour necrosis factor) as inflammatory markers, ICAM-1 (Intercellular Adhesion Molecule-1) as an endothelial dysfunctional marker, and glutathione, as an antioxidant, have abnormal levels in type 2 diabetic patients. The aim of this study was to evaluate the specific biological picture of type 2 diabetic patients that also associate higher GGT activity.

Published
2024
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3. Serum Plasminogen Activator Inhibitor-1, α 1-Acid Glycoprotein, C-Reactive Protein, and Platelet Factor 4 Levels—Promising Molecules That Can Complete the “Puzzle” of the Biochemical Milieu in Severe Burns: Preliminary Results of a Cohort Prospective Study

Author

Badoiu, Silviu Constantin, primary, Enescu, Dan Mircea, additional, Tatar, Raluca, additional, Stanescu-Spinu, Iulia-Ioana, additional, Miricescu, Daniela, additional, Greabu, Maria, additional, Ionel, Ileana Paula, additional, and Jinga, Viorel, additional

Published
2024
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5. Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer

Author

Morgos, Diana-Theodora, primary, Stefani, Constantin, additional, Miricescu, Daniela, additional, Greabu, Maria, additional, Stanciu, Silviu, additional, Nica, Silvia, additional, Stanescu-Spinu, Iulia-Ioana, additional, Balan, Daniela Gabriela, additional, Balcangiu-Stroescu, Andra-Elena, additional, Coculescu, Elena-Claudia, additional, Georgescu, Dragos-Eugen, additional, and Nica, Remus Iulian, additional

Published
2024
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6. mTOR Dysregulation, Insulin Resistance, and Hypertension.

Author

Stanciu, Silviu Marcel, Jinga, Mariana, Miricescu, Daniela, Stefani, Constantin, Nica, Remus Iulian, Stanescu-Spinu, Iulia-Ioana, Vacaroiu, Ileana Adela, Greabu, Maria, and Nica, Silvia

Subjects
INSULIN resistance, METABOLIC syndrome, CARDIOVASCULAR diseases, MTOR inhibitors, PROTEIN kinases, SERINE/THREONINE kinases
Abstract

Worldwide, diabetes mellitus (DM) and cardiovascular diseases (CVDs) represent serious health problems associated with unhealthy diet and sedentarism. Metabolic syndrome (MetS) is characterized by obesity, dyslipidemia, hyperglycemia, insulin resistance (IR) and hypertension. The mammalian target of rapamycin (mTOR) is a serine/threonine kinase with key roles in glucose and lipid metabolism, cell growth, survival and proliferation. mTOR hyperactivation disturbs glucose metabolism, leading to hyperglycemia and further to IR, with a higher incidence in the Western population. Metformin is one of the most used hypoglycemic drugs, with anti-inflammatory, antioxidant and antitumoral properties, having also the capacity to inhibit mTOR. mTOR inhibitors such as rapamycin and its analogs everolimus and temsirolimus block mTOR activity, decrease the levels of glucose and triglycerides, and reduce body weight. The link between mTOR dysregulation, IR, hypertension and mTOR inhibitors has not been fully described. Therefore, the main aim of this narrative review is to present the mechanism by which nutrients, proinflammatory cytokines, increased salt intake and renin–angiotensin–aldosterone system (RAAS) dysregulation induce mTOR overactivation, associated further with IR and hypertension development, and also mTOR inhibitors with higher potential to block the activity of this protein kinase. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Adipokines—A Cohort Prospective Study in Children with Severe Burns.

Author

Badoiu, Silviu Constantin, Enescu, Dan Mircea, Tatar, Raluca, Miricescu, Daniela, Stanescu-Spinu, Iulia-Ioana, Greabu, Maria, Coricovac, Anca Magdalena, Badoiu, Silvia Elena, and Jinga, Viorel

Subjects
ADIPOKINES, LEPTIN, RESISTIN, PLASMINOGEN activators, LONGITUDINAL method, COHORT analysis, ADIPONECTIN
Abstract

Burns generate every year an important burden of morbidity, being a major global public health problem through prolonged hospitalization, complications, and increased mortality. This study's purpose was to evaluate the serum levels of three adipokines and to establish significant correlations with other circulating molecules and with some clinical parameters. We evaluated 32 children with severe burns (over 25% total burned surface area—TBSA) at 48 h, day 10, and day 21 post burn, and 21 controls. The serum levels of adiponectin, resistin, leptin, tumor necrosis factor-α (TNF-α), plasminogen activator inhibitor-1 (PAI-1), and C-reactive protein (CRP) (among nine other biochemical parameters) were detected by Multiplex technique. Significant statistical differences were obtained for resistin and leptin compared to the control group, in different moments of measurements. Adiponectin serum levels presented statistically significant correlations with hot liquid mechanism of burn, the Revised Baux score, TBSA, resistin, PAI-1, CRP, TNF-α, and triglycerides (TGLs) serum levels. Resistin serum levels presented statistically significant correlations with adiponectin, CRP, PAI-1, leptin, and TNF-α. Additionally, we found statistically significant correlations between leptin serum levels and length of hospitalization, TNF-α, resistin, adiponectin, and PAI-1 serum levels. In severely burned children, adiponectin, resistin, and leptin specifically correlate with clinical parameters and with proteins involved in the systemic inflammatory response and the hypermetabolic response. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Chronic Pelvic Puzzle: Navigating Deep Endometriosis with Renal Complications.

Author

Vacaroiu, Ileana Adela, Balcangiu-Stroescu, Andra-Elena, Stanescu-Spinu, Iulia-Ioana, Balan, Daniela Gabriela, Georgescu, Mihai-Teodor, Greabu, Maria, Miricescu, Daniela, Cuiban, Elena, Șerban-Feier, Larisa Florina, Lupușoru, Mircea Ovidiu Denis, Gaube, Alexandra, and Georgescu, Dragos-Eugen

Subjects
PELVIC pain, ENDOMETRIOSIS, URINARY organs, SURGICAL diagnosis, CHRONIC pain, PUZZLES
Abstract

This case report delves into the intricacies of a challenging clinical scenario involving deep pelvic endometriosis, which manifested with renal complications. Endometriosis, a complex gynecological condition, is explored in this case, highlighting its multifaceted nature. The patient presented with a complex interplay of symptoms, including chronic pelvic pain, urinary tract issues, and severe deep adenomyosis. The diagnostic journey was protracted, emphasizing the need for early recognition and intervention in such cases. A thorough evaluation, including laparoscopic examination and histopathological analysis, revealed the extensive presence of endometriotic lesions in various pelvic and renal structures, ultimately leading to left hydronephrosis. The report underscores the significance of timely diagnosis and surgical intervention to prevent irreversible renal damage. This case provides valuable insights into the management of deep endometriosis with renal involvement and the importance of interdisciplinary collaboration. Understanding the complexities of this condition can aid in improving patient outcomes and enhancing the quality of care provided. [ABSTRACT FROM AUTHOR]

Published
2024
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11. PI3K/AKT/mTOR Dysregulation and Reprogramming Metabolic Pathways in Renal Cancer: Crosstalk with the VHL/HIF Axis

Author

Badoiu, Silviu Constantin, primary, Greabu, Maria, additional, Miricescu, Daniela, additional, Stanescu-Spinu, Iulia-Ioana, additional, Ilinca, Radu, additional, Balan, Daniela Gabriela, additional, Balcangiu-Stroescu, Andra-Elena, additional, Mihai, Doina-Andrada, additional, Vacaroiu, Ileana Adela, additional, Stefani, Constantin, additional, and Jinga, Viorel, additional

Published
2023
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16. Compressive and Flexural Strength of 3D-Printed and Conventional Resins Designated for Interim Fixed Dental Prostheses: An In Vitro Comparison

Author

Pantea, Mihaela, primary, Ciocoiu, Robert Cătălin, additional, Greabu, Maria, additional, Ripszky Totan, Alexandra, additional, Imre, Marina, additional, Țâncu, Ana Maria Cristina, additional, Sfeatcu, Ruxandra, additional, Spînu, Tudor Claudiu, additional, Ilinca, Radu, additional, and Petre, Alexandru Eugen, additional

Published
2022
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20. The Yin and Yang dualistic features of autophagy in thermal burn wound healing

Author

Ripszky Totan, Alexandra, primary, Greabu, Maria, additional, Stanescu-Spinu, Iulia-Ioana, additional, Imre, Marina, additional, Spinu, Tudor-Claudiu, additional, Miricescu, Daniela, additional, Ilinca, Radu, additional, Coculescu, Elena Claudia, additional, Badoiu, Silviu Constantin, additional, Coculescu, Bogdan-Ioan, additional, and Albu, Crenguta, additional

Published
2022
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22. Biochemical Mapping of the Inflamed Human Dental Pulp

Author

Kritikou, Konstantina, primary, Totan, Alexandra Ripszky, additional, Miricescu, Daniela, additional, Stanescu-Spinu, Iulia-Ioana, additional, Greabu, Maria, additional, Imre, Marina, additional, Tanase, Mihaela, additional, Vinereanu, Arina, additional, Spinu, Tudor-Claudiu, additional, and Ilinca, Radu, additional

Published
2021
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27. Autophagy-A Hidden but Important Actor on Oral Cancer Scene

Author

Radulescu Radu, BencZe Maria, Totan Alexandra, Greabu Maria, Miricescu Daniela, Tancu Ana Maria, Spinu Tudor, Stanescu Iulia Ioana, and Imre Melescanu Marina

Subjects
0301 basic medicine, Programmed cell death, autophagy, Review, Catalysis, lcsh:Chemistry, Inorganic Chemistry, 03 medical and health sciences, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Medicine, Animals, Humans, Physical and Theoretical Chemistry, lcsh:QH301-705.5, Molecular Biology, Protein kinase B, Spectroscopy, PI3K/AKT/mTOR pathway, business.industry, Kinase, TOR Serine-Threonine Kinases, Organic Chemistry, Autophagy, Cancer, General Medicine, oral cancer, medicine.disease, Computer Science Applications, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Mouth Neoplasms, business, Homeostasis, Signal Transduction, PI3K/AKT/mTOR signaling pathway
Abstract

The duration of denture use, oral hygiene, smoking and male sex were identified as risk factors for oral mucosal lesions. As it is well known, all the oral mucosal lesions associated with risk factors have an important degree of malignity. Chronic mechanical irritation can be another cause of oral cancer and it is produced by the constant action of a deleterious agent from the oral cavity. Autophagy represents a complex evolutionary conserved catabolic process in which cells self-digest intracellular organelles in order to regulate their normal turnover and remove the damaged ones with compromised function to further maintain homeostasis. Autophagy is modulated by mTOR kinase and indirectly by PI3K/AKT survival pathway. Due to its dual capacity to either induce cell death or promote cell survival, important evidence pointed that autophagy has a two-faced role in response to chemotherapy in cancer. In conclusion, understanding how to overcome cytoprotective autophagy and how to take advantage of autophagic cell death is critical in order to enhance the cancer cells sensitivity to particular therapeutic agents.

Published
2020

31. Glucose Metabolism in Burns—What Happens?

Author

Badoiu, Silviu Constantin, primary, Miricescu, Daniela, additional, Stanescu-Spinu, Iulia-Ioana, additional, Ripszky Totan, Alexandra, additional, Badoiu, Silvia Elena, additional, Costagliola, Michel, additional, and Greabu, Maria, additional

Published
2021
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35. Diagnostic Role of Saliva in Oral Cancers

Author

Radulescu, Radu, primary, Greabu, Maria, additional, Totan, Alexandra, additional, Imre, Marina Melescanu, additional, Miricescu, Daniela, additional, Didilescu, Andreea, additional, Sfeatcu, Ruxandra, additional, and Totan, Cosmin, additional

Published
2020
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37. A Review on the Biocompatibility of PMMA-Based Dental Materials for Interim Prosthetic Restorations with a Glimpse into Their Modern Manufacturing Techniques

Author

Pituru, Silviu Mirel, primary, Greabu, Maria, additional, Totan, Alexandra, additional, Imre, Marina, additional, Pantea, Mihaela, additional, Spinu, Tudor, additional, Tancu, Ana Maria Cristina, additional, Popoviciu, Nicoleta Olivia, additional, Stanescu, Iulia-Ioana, additional, and Ionescu, Ecaterina, additional

Published
2020
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42. Hypercaloric Diet and Vitamin E Intake

Author

Radulescu, Catalina, primary, Miricescu, Daniela, additional, Totan, Alexandra, additional, Didilescu, Andreea Cristina, additional, Stanescu, Iulia-Ioana, additional, Radulescu, Radu, additional, Stanescu, Ana Maria Alexandra, additional, Stefani, Constantin, additional, and Greabu, Maria, additional

Published
2019
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43. Interactions Between Dental Composite Resins and Saliva A comparative biochemical in vitro study

Author

Pantea, Mihaela, primary, Ighigeanu, Diana Andreea, additional, Totan, Alexandra, additional, Greabu, Maria, additional, Miricescu, Daniela, additional, Imre, marina Melescanu, additional, Totan, Cosmin, additional, Spinu, Tudor Claudiu, additional, Petre, Alexandru, additional, Bencze, Angelica, additional, Milicescu, Stefan, additional, and Tancu, Ana Maria Cristina, additional

Published
2019
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