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3. Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Author

Kadalayil, L., Alam, M., White, C.H., Ghantous, A., Walton, E., Gruzieva, O., Merid, S.K., Kumar, A., Roy, R., Solomon, O., Huen, K., Eskenazi, B., Rzehak, P., Grote, V., Langhendries, J.-P., Verduci, E., Ferre, N., Gruszfeld, D., Gao, L., Guan, W., Zeng, X., Schisterman, E.F., Dou, J., Bakulski, K.M., Feinberg, J.I., Soomro, M.H., Pesce, G., Baiz, N., Isaevska, E., Plusquin, M., Vafeiadi, M., Roumeliotaki, T., Langie, S.A.S., Standaert, A., Allard, C., Perron, P., Bouchard, L., van Meel, E.R., Felix, J.F., Jaddoe, V.W.V., Yousefi, P.D., Ramlau‑Hansen, C.H., Relton, C.L., Tobi, E.W., Starling, A.P., Yang, I.V., Llambrich, M., Santorelli, G., Lepeule, J., Salas, L.A., Bustamante, M., Ewart, S.L., Zhang, H., Karmaus, W., Röder, Stefan, Zenclussen, Ana Claudia, Jin, J., Nystad, W., Page, C.M., Magnus, M., Jima, D.D., Hoyo, C., Maguire, R.L., Kvist, T., Czamara, D., Räikkönen, K., Gong, T., Ullemar, V., Rifas‐Shiman, S.L., Oken, E., Almqvist, C., Karlsson, R., Lahti, J., Murphy, S.K., Håberg, S.E., London, S., Herberth, Gunda, Arshad, H., Sunyer, J., Grazuleviciene, R., Dabelea, D., Steegers‑Theunissen, R.P.M., Nohr, E.A., Sørensen, T.I.A., Duijts, L., Hivert, M.-F., Nelen, V., Popovic, M., Kogevinas, M., Nawrot, T.S., Herceg, Z., Annesi‑Maesano, I., Fallin, M.D., Yeung, E., Breton, C.V., Koletzko, B., Holland, N., Melén, E., Sharp, G.C., Silver, M.J., Kadalayil, L., Alam, M., White, C.H., Ghantous, A., Walton, E., Gruzieva, O., Merid, S.K., Kumar, A., Roy, R., Solomon, O., Huen, K., Eskenazi, B., Rzehak, P., Grote, V., Langhendries, J.-P., Verduci, E., Ferre, N., Gruszfeld, D., Gao, L., Guan, W., Zeng, X., Schisterman, E.F., Dou, J., Bakulski, K.M., Feinberg, J.I., Soomro, M.H., Pesce, G., Baiz, N., Isaevska, E., Plusquin, M., Vafeiadi, M., Roumeliotaki, T., Langie, S.A.S., Standaert, A., Allard, C., Perron, P., Bouchard, L., van Meel, E.R., Felix, J.F., Jaddoe, V.W.V., Yousefi, P.D., Ramlau‑Hansen, C.H., Relton, C.L., Tobi, E.W., Starling, A.P., Yang, I.V., Llambrich, M., Santorelli, G., Lepeule, J., Salas, L.A., Bustamante, M., Ewart, S.L., Zhang, H., Karmaus, W., Röder, Stefan, Zenclussen, Ana Claudia, Jin, J., Nystad, W., Page, C.M., Magnus, M., Jima, D.D., Hoyo, C., Maguire, R.L., Kvist, T., Czamara, D., Räikkönen, K., Gong, T., Ullemar, V., Rifas‐Shiman, S.L., Oken, E., Almqvist, C., Karlsson, R., Lahti, J., Murphy, S.K., Håberg, S.E., London, S., Herberth, Gunda, Arshad, H., Sunyer, J., Grazuleviciene, R., Dabelea, D., Steegers‑Theunissen, R.P.M., Nohr, E.A., Sørensen, T.I.A., Duijts, L., Hivert, M.-F., Nelen, V., Popovic, M., Kogevinas, M., Nawrot, T.S., Herceg, Z., Annesi‑Maesano, I., Fallin, M.D., Yeung, E., Breton, C.V., Koletzko, B., Holland, N., Melén, E., Sharp, G.C., and Silver, M.J.

Abstract

BackgroundSeasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms underlying the associations between birth season and lifelong phenotypes remains unclear.MethodsWe carried out epigenome-wide meta-analyses within the Pregnancy And Childhood Epigenetic Consortium to identify associations of DNAm with birth season, both at differentially methylated probes (DMPs) and regions (DMRs). Associations were examined at two time points: at birth (21 cohorts, N = 9358) and in children aged 1–11 years (12 cohorts, N = 3610). We conducted meta-analyses to assess the impact of latitude on birth season-specific associations at both time points.ResultsWe identified associations between birth season and DNAm (False Discovery Rate-adjusted p values < 0.05) at two CpGs at birth (winter-born) and four in the childhood (summer-born) analyses when compared to children born in autumn. Furthermore, we identified twenty-six differentially methylated regions (DMR) at birth (winter-born: 8, spring-born: 15, summer-born: 3) and thirty-two in childhood (winter-born: 12, spring and summer: 10 each) meta-analyses with few overlapping DMRs between the birth seasons or the two time points. The DMRs were associated with genes of known functions in tumorigenesis, psychiatric/neurological disorders, inflammation, or immunity, amongst others. Latitude-stratified meta-analyses [higher (≥ 50°N), lower (< 50°N, northern hemisphere only)] revealed differences in associations between birth season and DNAm by birth latitude. DMR analysis implicated genes with previously reported links to schizophrenia (LAX1), skin disorders (PSORS1C, LTB4R), and airway inflammation including asthma (LTB4R), present only at birth in the higher latitudes (≥ 50°N).ConclusiosIn this large epigenome-wide meta-analysis study, we provide eviden

Published
2023

4. Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Author

Universitat Rovira i Virgili, Kadalayil, L; Alam, MZ; White, CH; Ghantous, A; Walton, E; Gruzieva, O; Merid, SK; Kumar, A; Roy, RP; Solomon, O; Huen, K; Eskenazi, B; Rzehak, P; Grote, V; Langhendries, JP; Verduci, E; Ferre, N; Gruszfeld, D; Gao, L; Guan, WH; Zeng, XH; Schisterman, EF; Dou, JF; Bakulski, KM; Feinberg, JI; Soomro, MH; Pesce, G; Baiz, N; Isaevska, E; Plusquin, M; Vafeiadi, M; Roumeliotaki, T; Langie, SAS; Standaert, A; Allard, C; Perron, P; Bouchard, L; van Meel, ER; Felix, JF; Jaddoe, VWV; Yousefi, PD; Ramlau-Hansen, CH; Relton, CL; Tobi, EW; Starling, AP; Yang, IV; Llambrich, M; Santorelli, G; Lepeule, J; Salas, LA; Bustamante, M; Ewart, SL; Zhang, HM; Karmaus, W; Röder, S; Zenclussen, AC; Jin, JP; Nystad, W; Page, CM; Magnus, M; Jima, DD; Hoyo, C; Maguire, RL; Kvist, T; Czamara, D; Räikkönen, K; Gong, T; Ullemar, V; Rifas-Shiman, SL; Oken, E; Almqvist, C; Karlsson, R; Lahti, J; Murphy, SK; Håberg, SE; London, S; Herberth, G; Arshad, H; Sunyer, J; Grazuleviciene, R; Dabelea, D; Steegers-Theunissen, RPM; Nohr, EA; Sorensen, TIA; Duijts, L; Hivert, MF; Nelen, V; Popovic, M; Kogevinas, M; Nawrot, TS; Herceg, Z; Annesi-Maesano, I; Fallin, MD; Yeung, EDA; Breton, CV; Koletzko, B; Holland, N; Wiemels, JL; Melén, E; Sharp, GC; Silver, MJ; Rezwan, F; Holloway, JW, Universitat Rovira i Virgili, and Kadalayil, L; Alam, MZ; White, CH; Ghantous, A; Walton, E; Gruzieva, O; Merid, SK; Kumar, A; Roy, RP; Solomon, O; Huen, K; Eskenazi, B; Rzehak, P; Grote, V; Langhendries, JP; Verduci, E; Ferre, N; Gruszfeld, D; Gao, L; Guan, WH; Zeng, XH; Schisterman, EF; Dou, JF; Bakulski, KM; Feinberg, JI; Soomro, MH; Pesce, G; Baiz, N; Isaevska, E; Plusquin, M; Vafeiadi, M; Roumeliotaki, T; Langie, SAS; Standaert, A; Allard, C; Perron, P; Bouchard, L; van Meel, ER; Felix, JF; Jaddoe, VWV; Yousefi, PD; Ramlau-Hansen, CH; Relton, CL; Tobi, EW; Starling, AP; Yang, IV; Llambrich, M; Santorelli, G; Lepeule, J; Salas, LA; Bustamante, M; Ewart, SL; Zhang, HM; Karmaus, W; Röder, S; Zenclussen, AC; Jin, JP; Nystad, W; Page, CM; Magnus, M; Jima, DD; Hoyo, C; Maguire, RL; Kvist, T; Czamara, D; Räikkönen, K; Gong, T; Ullemar, V; Rifas-Shiman, SL; Oken, E; Almqvist, C; Karlsson, R; Lahti, J; Murphy, SK; Håberg, SE; London, S; Herberth, G; Arshad, H; Sunyer, J; Grazuleviciene, R; Dabelea, D; Steegers-Theunissen, RPM; Nohr, EA; Sorensen, TIA; Duijts, L; Hivert, MF; Nelen, V; Popovic, M; Kogevinas, M; Nawrot, TS; Herceg, Z; Annesi-Maesano, I; Fallin, MD; Yeung, EDA; Breton, CV; Koletzko, B; Holland, N; Wiemels, JL; Melén, E; Sharp, GC; Silver, MJ; Rezwan, F; Holloway, JW

Abstract

Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms underlying the associations between birth season and lifelong phenotypes remains unclear.We carried out epigenome-wide meta-analyses within the Pregnancy And Childhood Epigenetic Consortium to identify associations of DNAm with birth season, both at differentially methylated probes (DMPs) and regions (DMRs). Associations were examined at two time points: at birth (21 cohorts, N = 9358) and in children aged 1-11 years (12 cohorts, N = 3610). We conducted meta-analyses to assess the impact of latitude on birth season-specific associations at both time points.We identified associations between birth season and DNAm (False Discovery Rate-adjusted p values < 0.05) at two CpGs at birth (winter-born) and four in the childhood (summer-born) analyses when compared to children born in autumn. Furthermore, we identified twenty-six differentially methylated regions (DMR) at birth (winter-born: 8, spring-born: 15, summer-born: 3) and thirty-two in childhood (winter-born: 12, spring and summer: 10 each) meta-analyses with few overlapping DMRs between the birth seasons or the two time points. The DMRs were associated with genes of known functions in tumorigenesis, psychiatric/neurological disorders, inflammation, or immunity, amongst others. Latitude-stratified meta-analyses [higher (≥ 50°N), lower (< 50°N, northern hemisphere only)] revealed differences in associations between birth season and DNAm by birth latitude. DMR analysis implicated genes with previously reported links to schizophrenia (LAX1), skin disorders (PSORS1C, LTB4R), and airway inflammation inclu

Published
2023

5. Associations of four biological age markers with child development: a multi-omic analysis in the European HELIX cohort

Author

Robinson, O, Lau, C-HE, Joo, S, Andrusaityte, S, Borras, E, De Prado-Bert, P, Chatzi, L, Keun, HC, and Grazuleviciene, R

Abstract

Background: While biological age in adults is often understood as representing general health and resilience, the conceptual interpretation of accelerated biological age in children and its relationship to development remains unclear. We aimed to clarify the relationship of accelerated biological age, assessed through two established biological age indicators, telomere length and DNA methylation age, and two novel candidate biological age indicators , to child developmental outcomes, including growth and adiposity, cognition, behaviour, lung function and onset of puberty, among European school-age children participating in the HELIX exposome cohort. Methods: The study population included up to 1,173 children, aged between 5 and 12 years, from study centres in the UK, France, Spain, Norway, Lithuania, and Greece. Telomere length was measured through qPCR, blood DNA methylation and gene expression was measured using microarray, and proteins and metabolites were measured by a range of targeted assays. DNA methylation age was assessed using Horvath's skin and blood clock, while novel blood transcriptome and 'immunometabolic' (based on plasma protein and urinary and serum metabolite data) clocks were derived and tested in a subset of children assessed six months after the main follow-up visit. Associations between biological age indicators with child developmental measures as well as health risk factors were estimated using linear regression, adjusted for chronological age, sex, ethnicity and study centre. The clock derived markers were expressed as Δ age (i.e., predicted minus chronological age). Results: Transcriptome and immunometabolic clocks predicted chronological age well in the test set (r= 0.93 and r= 0.84 respectively). Generally, weak correlations were observed, after adjustment for chronological age, between the biological age indicators. Among associations with health risk factors, higher birthweight was associated with greater immunometabolic Δ age, smoke exposure with greater DNA methylation Δ age and high family affluence with longer telomere length. Among associations with child developmental measures, all biological age markers were associated with greater BMI and fat mass, and all markers except telomere length were associated with greater height, at least at nominal significance (p

Published
2023

6. Longitudinal associations of DNA methylation and sleep in children: a meta‑analysis

Author

Sammallahti, S., Koopman‑Verhoeff, M.E., Binter, A.-C., Mulder, R.H., Cabré‑Riera, A., Kvist, T., Malmberg, A.L.K., Pesce, G., Plancoulaine, S., Heiss, J.A., Rifas‐Shiman, S.L., Röder, Stefan, Starling, A.P., Wilson, R., Guerlich, K., Haftorn, K.L., Page, C.M., Luik, A.I., Tiemeier, H., Felix, J.F., Raikkonen, K., Lahti, J., Relton, C.L., Sharp, G.C., Waldenberger, M., Grote, V., Heude, B., Annesi‑Maesano, I., Hivert, M.-F., Zenclussen, Ana Claudia, Herberth, Gunda, Dabelea, D., Grazuleviciene, R., Vafeiadi, M., Håberg, S.E., London, S.J., Guxens, M., Richmond, R.C., Cecil, C.A.M., Sammallahti, S., Koopman‑Verhoeff, M.E., Binter, A.-C., Mulder, R.H., Cabré‑Riera, A., Kvist, T., Malmberg, A.L.K., Pesce, G., Plancoulaine, S., Heiss, J.A., Rifas‐Shiman, S.L., Röder, Stefan, Starling, A.P., Wilson, R., Guerlich, K., Haftorn, K.L., Page, C.M., Luik, A.I., Tiemeier, H., Felix, J.F., Raikkonen, K., Lahti, J., Relton, C.L., Sharp, G.C., Waldenberger, M., Grote, V., Heude, B., Annesi‑Maesano, I., Hivert, M.-F., Zenclussen, Ana Claudia, Herberth, Gunda, Dabelea, D., Grazuleviciene, R., Vafeiadi, M., Håberg, S.E., London, S.J., Guxens, M., Richmond, R.C., and Cecil, C.A.M.

Abstract

Background Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children. Methods We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4–13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration. Results We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × 10–8). Lower methylation at cg24815001 and cg02753354 at birth was associated with longer actigraphy-estimated sleep duration (p = 3.31 × 10–8, n = 577) and sleep onset latency (p = 8.8 × 10–9, n = 580), respectively. DNA methylation in childhood was not cross-sectionally associated with any sleep outcomes (n = 716–2539). Conclusion DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. Associations observed with objectively measured sleep outcomes could be studied further if additional data sets become available. &nbsp

Published
2022

7. Unravelling sex-specific BPA toxicokinetics in children using a pediatric PBPK model

Author

Universitat Rovira i Virgili, Deepika D; Sharma RP; Schuhmacher M; Sakhi AK; Thomsen C; Chatzi L; Vafeiadi M; Quentin J; Slama R; Grazuleviciene R; Andrušaitytė S; Waiblinger D; Wright J; Yang TC; Urquiza J; Vrijheid M; Casas M; Domingo JL; Kumar V, Universitat Rovira i Virgili, and Deepika D; Sharma RP; Schuhmacher M; Sakhi AK; Thomsen C; Chatzi L; Vafeiadi M; Quentin J; Slama R; Grazuleviciene R; Andrušaitytė S; Waiblinger D; Wright J; Yang TC; Urquiza J; Vrijheid M; Casas M; Domingo JL; Kumar V

Abstract

Bisphenol A (BPA) is a widely known endocrine disruptor (ED) found in many children's products such as toys, feeding utensils, and teething rings. Recent epidemiology association studies have shown postnatal BPA exposure resulted in developing various diseases such as diabetes, obesity, and neurodegeneration, etc., later in their lives. However, little is known about its sex-specific metabolism and consequently internal exposure. The aim of this study was to develop a sex-specific pediatric physiologically based pharmacokinetic model (PBPK) for BPA to compare their toxicokinetic differences. First, the published adult PBPK model was re-validated, and then this model was extended by interpolation to incorporate pediatric sex specific physiological and biochemical parameters. We used both the classical body weight and ontogeny-based scaling approach to interpolate the metabolic process. Then, the pharmacokinetic attributes of the models using the two-scaling approach mentioned above were compared with adult model. Further, a sex-specific PBPK model with an ontogeny scaling approach was preferred to evaluate the pharmacokinetic differences. Moreover, this model was used to reconstruct the BPA exposure from two cohorts (Helix and PBAT Cohort) from 7 EU countries. The half-life of BPA was found to be almost the same in boys and girls at the same exposure levels. Our model estimated BPA children's exposure to be about 1500 times higher than the tolerable daily intake (TDI) recently set by European Food Safety Authority (EFSA) i.e., 0.04 ng/kg BW/day. The model demonstrated feasibility of extending the adult PBPK to sex-specific pediatric, thus investigate a gender-specific health risk assessment.

Published
2022

10. Narrative review of citizen science in environmental epidemiology: Setting the stage for co-created research projects in environmental epidemiology

Author

Froeling, F., Hoek, G., Vermeulen, R., Nieuwenhuijsen, M., Ficorilli, A., De Marchi, B., Biggeri, A., Kocman, D., Robinson, J.A., Grazuleviciene, R., Andrusaityte, S., Righi, V., Basagaña, X., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, and dIRAS RA-I&I RA

Subjects
Participatory research, Environmental health, Environmental Science(all), Co-creation, Environmental epidemiology, Citizen science
Abstract

Several citizen science (CS) initiatives have been adopted in environmental science to monitor air and noise pollution, and water quality related to civic concerns. Nevertheless, CS projects in environmental epidemiology remain scarce. This is because little attention has been paid to evaluate associations of environmental exposures with health effects directly. This narrative review aims to promote the understanding and application of CS in environmental epidemiology. There are many commonalities between CS and other participatory approaches in environmental epidemiology. Yet, CS can foster the democratization of scientific governance and enhance the sustainability of research projects more effectively than other existing participatory approaches. This is especially the case in projects where citizens are invited to participate, engage and become involved throughout all the phases of a research project (co-created projects). This paper identifies various challenges and opportunities specific to the implementation of co-created CS projects in environmental epidemiology. The development of more locally relevant research designs, using local knowledge, obtaining medical ethical clearance, and co-analysing the association between exposure and health, are examples of opportunities and challenges that require epidemiologists to go beyond the traditional research framework and include more outreach activities. Continued efforts, particularly the sharing of information about projects' collaborative processes, are needed to make CS a more concrete and cohesive approach in environmental epidemiology.

Published
2021

13. DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

Author

Dongen, J. Van, Hagenbeek, F.A., Suderman, M., Roetman, P.J., Sugden, K., Chiocchetti, A.G., Ismail, K., Mulder, R.H., Hafferty, J.D., Adams, M.J., Walker, R.M., Morris, S.W., Lahti, J., Küpers, L.K., Escaramis, G., Alemany, S., Bonder, M. Jan, Meijer, M., Ip, H.F., Jansen, R., Baselmans, B.M.L., Parmar, P., Lowry, E., Streit, F., Sirignano, L., Send, T.S., Frank, J., Jylhävä, J., Wang, Y., Mishra, P.P., Colins, O.F., Corcoran, D.L., Poulton, R., Mill, J., Hannon, E., Arseneault, L., Korhonen, T., Vuoksimaa, E., Felix, J.F., Bakermans-Kranenburg, M.J., Campbell, A., Czamara, D., Binder, E., Corpeleijn, E., Gonzalez, J.R., Grazuleviciene, R., Gutzkow, K.B., Evandt, J., Vafeiadi, M., Klein, M., Meer, D. van der, Ligthart, L., Kluft, C., Davies, G.E., Hakulinen, C., Keltikangas-Järvinen, L., Franke, B., Freitag, C.M., Konrad, K., Hervas, A., Fernández-Rivas, A., Vetro, A., Raitakari, O., Lehtimäki, T., Vermeiren, R., Strandberg, T., Räikkönen, K., Snieder, H., Witt, S.H., Deuschle, M., Pedersen, N.L., Hägg, S., Sunyer, J., Franke, L., Kaprio, J., Ollikainen, M., Moffitt, T.E., Tiemeier, H., van, I.M.H., Relton, C., Vrijheid, M., Sebert, S., Jarvelin, M.R., Caspi, A., Evans, K.L., McIntosh, A.M., Bartels, M., Boomsma, D.I., Dongen, J. Van, Hagenbeek, F.A., Suderman, M., Roetman, P.J., Sugden, K., Chiocchetti, A.G., Ismail, K., Mulder, R.H., Hafferty, J.D., Adams, M.J., Walker, R.M., Morris, S.W., Lahti, J., Küpers, L.K., Escaramis, G., Alemany, S., Bonder, M. Jan, Meijer, M., Ip, H.F., Jansen, R., Baselmans, B.M.L., Parmar, P., Lowry, E., Streit, F., Sirignano, L., Send, T.S., Frank, J., Jylhävä, J., Wang, Y., Mishra, P.P., Colins, O.F., Corcoran, D.L., Poulton, R., Mill, J., Hannon, E., Arseneault, L., Korhonen, T., Vuoksimaa, E., Felix, J.F., Bakermans-Kranenburg, M.J., Campbell, A., Czamara, D., Binder, E., Corpeleijn, E., Gonzalez, J.R., Grazuleviciene, R., Gutzkow, K.B., Evandt, J., Vafeiadi, M., Klein, M., Meer, D. van der, Ligthart, L., Kluft, C., Davies, G.E., Hakulinen, C., Keltikangas-Järvinen, L., Franke, B., Freitag, C.M., Konrad, K., Hervas, A., Fernández-Rivas, A., Vetro, A., Raitakari, O., Lehtimäki, T., Vermeiren, R., Strandberg, T., Räikkönen, K., Snieder, H., Witt, S.H., Deuschle, M., Pedersen, N.L., Hägg, S., Sunyer, J., Franke, L., Kaprio, J., Ollikainen, M., Moffitt, T.E., Tiemeier, H., van, I.M.H., Relton, C., Vrijheid, M., Sebert, S., Jarvelin, M.R., Caspi, A., Evans, K.L., McIntosh, A.M., Bartels, M., and Boomsma, D.I.

Abstract

Item does not contain fulltext, DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of epigenome-wide association studies (EWAS) of aggressive behavior (N = 15,324 participants). In peripheral blood samples of 14,434 participants from 18 cohorts with mean ages ranging from 7 to 68 years, 13 methylation sites were significantly associated with aggression (alpha = 1.2 × 10(-7); Bonferroni correction). In cord blood samples of 2425 children from five cohorts with aggression assessed at mean ages ranging from 4 to 7 years, 83% of these sites showed the same direction of association with childhood aggression (r = 0.74, p = 0.006) but no epigenome-wide significant sites were found. Top-sites (48 at a false discovery rate of 5% in the peripheral blood meta-analysis or in a combined meta-analysis of peripheral blood and cord blood) have been associated with chemical exposures, smoking, cognition, metabolic traits, and genetic variation (mQTLs). Three genes whose expression levels were associated with top-sites were previously linked to schizophrenia and general risk tolerance. At six CpGs, DNA methylation variation in blood mirrors variation in the brain. On average 44% (range = 3-82%) of the aggression-methylation association was explained by current and former smoking and BMI. These findings point at loci that are sensitive to chemical exposures with potential implications for neuronal functions. We hope these results to be a starting point for studies leading to applications as peripheral biomarkers and to reveal causal relationships with aggression and related traits.

Published
2021

14. DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

Author

Dongen, J. (Jenny) van, Hagenbeek, F.A. (Fiona A.), Suderman, M.J. (Matthew J.), Roetman, P.J. (Peter J.), Sugden, K. (Karen), Chiocchetti, A.G. (Andreas G.), Ismail, K. (Khadeeja), Mulder, R.H. (Rosa), Hafferty, J.D. (Jonathan D.), Adams, M.J. (Mark J.), Walker, R.M. (Rosie M.), Morris, S.W. (Stewart W.), Lahti, J. (Jari), Küpers, A.M. (Marlijn), Escaramis, G. (Georgia), Alemany, S. (Silvia), Jan Bonder, M. (Marc), Meijer, M. (Mandy), Ip, H.F. (Hill F.), Jansen, R. (Rick), Baselmans, B.M.L. (Bart M. L.), Parmar, P. (Priyanka), Lowry, E. (Estelle), Streit, F. (Fabian), Sirignano, L. (Lea), Send, T.S. (Tabea S.), Frank, J. (Josef), Jylhävä, J. (Juulia), Wang, Y. (Yunzhang), Mishra, P.P. (Pashupati Prasad), Colins, O.F. (Olivier F.), Corcoran, D.L. (David L.), Poulton, R. (Richie), Mill, J. (Jonathan), Hannon, E. (Eilis), Arseneault, L. (Louise), Korhonen, T. (Tellervo), Vuoksimaa, E. (Eero), Felix, J.F. (Janine), Bakermans-Kranenburg, M.J. (Marian), Campbell, A. (Archie), Czamara, D. (Darina), Binder, E.B. (Elisabeth), Corpeleijn, E. (Eva), Gonzalez, J.R. (Juan R.), Grazuleviciene, R. (Regina), Gutzkow, K.B. (Kristine B.), Evandt, J. (Jorunn), Vafeiadi, M. (Marina), Klein, M. (Marieke), van der Meer, D. (Dennis), Ligthart, L. (Lannie), Kluft, C. (Cornelis), Davies, G.E. (Gareth E.), Hakulinen, C. (Christian), Keltikangas-Järvinen, L. (Liisa), Franke, B. (Barbara), Freitag, C.M. (Christine), Konrad, K. (Kerstin), Hervas, A. (Amaia), Fernández-Rivas, A. (Aranzazu), Vetro, A. (Agnes), Raitakari, O. (Olli), Lehtimäki, T. (Terho), Vermeiren, R.R.J.M. (Robert R.J.M.), Strandberg, T. (Timo), Räikkönen, K. (Katri), Snieder, H. (Harold), Witt, S.H. (Stephanie H), Deuschle, M. (Michael), Pedersen, N.L. (Nancy), Hägg, S. (Sara), Sunyer, J. (Jordi), Franke, L. (Lude), Kaprio, J. (Jaakko), Ollikainen, M. (Miina), Moffitt, T.E. (Terrie E.), Tiemeier, H.W. (Henning), IJzendoorn, M.H. (Rien) van, Relton, C.L. (Caroline), Vrijheid, M. (Martine), Sebert, S. (Sylvain), Jarvelin, M.-R. (Marjo-Riitta), Caspi, A. (Avshalom), Evans, K.L. (Kathryn L.), McIntosh, A.M. (Andrew), Bartels, M. (Meike), Boomsma, D.I. (Dorret I.), Dongen, J. (Jenny) van, Hagenbeek, F.A. (Fiona A.), Suderman, M.J. (Matthew J.), Roetman, P.J. (Peter J.), Sugden, K. (Karen), Chiocchetti, A.G. (Andreas G.), Ismail, K. (Khadeeja), Mulder, R.H. (Rosa), Hafferty, J.D. (Jonathan D.), Adams, M.J. (Mark J.), Walker, R.M. (Rosie M.), Morris, S.W. (Stewart W.), Lahti, J. (Jari), Küpers, A.M. (Marlijn), Escaramis, G. (Georgia), Alemany, S. (Silvia), Jan Bonder, M. (Marc), Meijer, M. (Mandy), Ip, H.F. (Hill F.), Jansen, R. (Rick), Baselmans, B.M.L. (Bart M. L.), Parmar, P. (Priyanka), Lowry, E. (Estelle), Streit, F. (Fabian), Sirignano, L. (Lea), Send, T.S. (Tabea S.), Frank, J. (Josef), Jylhävä, J. (Juulia), Wang, Y. (Yunzhang), Mishra, P.P. (Pashupati Prasad), Colins, O.F. (Olivier F.), Corcoran, D.L. (David L.), Poulton, R. (Richie), Mill, J. (Jonathan), Hannon, E. (Eilis), Arseneault, L. (Louise), Korhonen, T. (Tellervo), Vuoksimaa, E. (Eero), Felix, J.F. (Janine), Bakermans-Kranenburg, M.J. (Marian), Campbell, A. (Archie), Czamara, D. (Darina), Binder, E.B. (Elisabeth), Corpeleijn, E. (Eva), Gonzalez, J.R. (Juan R.), Grazuleviciene, R. (Regina), Gutzkow, K.B. (Kristine B.), Evandt, J. (Jorunn), Vafeiadi, M. (Marina), Klein, M. (Marieke), van der Meer, D. (Dennis), Ligthart, L. (Lannie), Kluft, C. (Cornelis), Davies, G.E. (Gareth E.), Hakulinen, C. (Christian), Keltikangas-Järvinen, L. (Liisa), Franke, B. (Barbara), Freitag, C.M. (Christine), Konrad, K. (Kerstin), Hervas, A. (Amaia), Fernández-Rivas, A. (Aranzazu), Vetro, A. (Agnes), Raitakari, O. (Olli), Lehtimäki, T. (Terho), Vermeiren, R.R.J.M. (Robert R.J.M.), Strandberg, T. (Timo), Räikkönen, K. (Katri), Snieder, H. (Harold), Witt, S.H. (Stephanie H), Deuschle, M. (Michael), Pedersen, N.L. (Nancy), Hägg, S. (Sara), Sunyer, J. (Jordi), Franke, L. (Lude), Kaprio, J. (Jaakko), Ollikainen, M. (Miina), Moffitt, T.E. (Terrie E.), Tiemeier, H.W. (Henning), IJzendoorn, M.H. (Rien) van, Relton, C.L. (Caroline), Vrijheid, M. (Martine), Sebert, S. (Sylvain), Jarvelin, M.-R. (Marjo-Riitta), Caspi, A. (Avshalom), Evans, K.L. (Kathryn L.), McIntosh, A.M. (Andrew), Bartels, M. (Meike), and Boomsma, D.I. (Dorret I.)

Abstract

DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of epigenome-wide association studies (EWAS) of aggressive behavior (N = 15,324 participants). In peripheral blood samples of 14,434 participants from 18 cohorts with mean ages ranging from 7 to 68 years, 13 methylation sites were significantly associated with aggression (alpha = 1.2 × 10−7; Bonferroni correction). In cord blood samples of 2425 children from five cohorts with aggression assessed at mean ages ranging from 4 to 7 years, 83% of these sites showed the same direction of association with childhood aggression (r = 0.74, p = 0.006) but no epigenome-wide significant sites were found. Top-sites (48

Published
2021
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15. Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age – An exposome-based approach in 5 European cohorts

Author

Jedynak, P. (Paulina), Maitre, L. (Léa), Guxens Junyent, M. (Mònica), Gützkow, K.B. (Kristine B.), Julvez, J. (Jordi), López-Vicente, M. (Mònica), Sunyer, J. (Jordi), Casas, M. (Maribel), Chatzi, L. (Leda), Grazuleviciene, R. (Regina), Kampouri, M. (Mariza), McEachan, R. (Rosie), Mon-Williams, M. (Mark), Tamayo, I. (Ibon), Thomsen, C. (Cathrine), Urquiza, J. (José), Vafeiadi, M. (Marina), Wright, J. (John), Basagaña, X. (Xavier), Vrijheid, M. (Martine), Philippat, C. (Claire), Jedynak, P. (Paulina), Maitre, L. (Léa), Guxens Junyent, M. (Mònica), Gützkow, K.B. (Kristine B.), Julvez, J. (Jordi), López-Vicente, M. (Mònica), Sunyer, J. (Jordi), Casas, M. (Maribel), Chatzi, L. (Leda), Grazuleviciene, R. (Regina), Kampouri, M. (Mariza), McEachan, R. (Rosie), Mon-Williams, M. (Mark), Tamayo, I. (Ibon), Thomsen, C. (Cathrine), Urquiza, J. (José), Vafeiadi, M. (Marina), Wright, J. (John), Basagaña, X. (Xavier), Vrijheid, M. (Martine), and Philippat, C. (Claire)

Abstract

Background: Studies looking at associations between environmental chemicals and child behaviour usually consider only one exposure or family of exposures. Objective: This study explores associations between prenatal exposure to a wide range of environmental chemicals and child behaviour. Methods: We studied 708 mother-child pairs from five European cohorts recruited in 2003–2009. We assessed 47 exposure biomarkers from eight chemical exposure families in maternal blood or urine collected during pregnancy. We used the Strengths and Difficulties Questionnaire (SDQ) to evaluate child behaviour between three and seven years of age. We assessed associations of SDQ scores with exposures using an adjusted least absolute shrinkage and selection operator (LASSO) considering all exposures simultaneously and an adjusted exposome-wide association study (ExWAS) considering each exposure independently. Results: LASSO selected only copper (Cu) as associated with externalizing behaviour. In the ExWAS, bisphenol A [BPA, incidence rate ratio (IRR): 1.06, 95% confidence interval (95%CI): 1.01;1.12] and mono-n-butyl phthalate (MnBP, IRR: 1.06, 95%CI: 1.00;1.13) were associated with greater risk of externalizing behaviour problems. Cu (IRR: 0.90, 95%CI: 0.82;0.98), perfluoroundecan

Published
2021
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16. Narrative review of citizen science in environmental epidemiology: Setting the stage for co-created research projects in environmental epidemiology

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, dIRAS RA-I&I RA, Froeling, F., Hoek, G., Vermeulen, R., Nieuwenhuijsen, M., Ficorilli, A., De Marchi, B., Biggeri, A., Kocman, D., Robinson, J.A., Grazuleviciene, R., Andrusaityte, S., Righi, V., Basagaña, X., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, dIRAS RA-I&I RA, Froeling, F., Hoek, G., Vermeulen, R., Nieuwenhuijsen, M., Ficorilli, A., De Marchi, B., Biggeri, A., Kocman, D., Robinson, J.A., Grazuleviciene, R., Andrusaityte, S., Righi, V., and Basagaña, X.

Published
2021

17. DNA methylation signatures of aggression and closely related constructs:a meta-analysis of epigenome-wide studies across the lifespan

Author

van Dongen, J. (Jenny), Hagenbeek, F. A. (Fiona A.), Suderman, M. (Matthew), Roetman, P. J. (Peter J.), Sugden, K. (Karen), Chiocchetti, A. G. (Andreas G.), Ismail, K. (Khadeeja), Mulder, R. H. (Rosa H.), Hafferty, J. D. (Jonathan D.), Adams, M. J. (Mark J.), Walker, R. M. (Rosie M.), Morris, S. W. (Stewart W.), Lahti, J. (Jari), Kupers, L. K. (Leanne K.), Escaramis, G. (Georgia), Alemany, S. (Silvia), Bonder, M. J. (Marc Jan), Meijer, M. (Mandy), Ip, H. F. (Hill F.), Jansen, R. (Rick), Baselmans, B. M. (Bart M. L.), Parmar, P. (Priyanka), Lowry, E. (Estelle), Streit, F. (Fabian), Sirignano, L. (Lea), Send, T. S. (Tabea S.), Frank, J. (Josef), Jylhava, J. (Juulia), Wang, Y. (Yunzhang), Mishra, P. P. (Pashupati Prasad), Colins, O. F. (Olivier F.), Corcoran, D. L. (David L.), Poulton, R. (Richie), Mill, J. (Jonathan), Hannon, E. (Eilis), Arseneault, L. (Louise), Korhonen, T. (Tellervo), Vuoksimaa, E. (Eero), Felix, J. F. (Janine F.), Bakermans-Kranenburg, M. J. (Marian J.), Campbell, A. (Archie), Czamara, D. (Darina), Binder, E. (Elisabeth), Corpeleijn, E. (Eva), Gonzalez, J. R. (Juan R.), Grazuleviciene, R. (Regina), Gutzkow, K. B. (Kristine B.), Evandt, J. (Jorunn), Vafeiadi, M. (Marina), Klein, M. (Marieke), van der Meer, D. (Dennis), Ligthart, L. (Lannie), Kluft, C. (Cornelis), Davies, G. E. (Gareth E.), Hakulinen, C. (Christian), Keltikangas-Jarvinen, L. (Liisa), Franke, B. (Barbara), Freitag, C. M. (Christine M.), Konrad, K. (Kerstin), Hervas, A. (Amaia), Fernandez-Rivas, A. (Aranzazu), Vetro, A. (Agnes), Raitakari, O. (Olli), Lehtimaki, T. (Terho), Vermeiren, R. (Robert), Strandberg, T. (Timo), Raikkonen, K. (Katri), Snieder, H. (Harold), Witt, S. H. (Stephanie H.), Deuschle, M. (Michael), Pedersen, N. L. (Nancy L.), Hagg, S. (Sara), Sunyer, J. (Jordi), Franke, L. (Lude), Kaprio, J. (Jaakko), Ollikainen, M. (Miina), Moffitt, T. E. (Terrie E.), Tiemeier, H. (Henning), van IJzendoorn, M. H. (Marinus H.), Relton, C. (Caroline), Vrijheid, M. (Martine), Sebert, S. (Sylvain), Järvelin, M.-R. (Marjo-Riitta), Caspi, A. (Avshalom), Evans, K. L. (Kathryn L.), McIntosh, A. M. (Andrew M.), Bartels, M. (Meike), Boomsma, D. I. (Dorret, I), van Dongen, J. (Jenny), Hagenbeek, F. A. (Fiona A.), Suderman, M. (Matthew), Roetman, P. J. (Peter J.), Sugden, K. (Karen), Chiocchetti, A. G. (Andreas G.), Ismail, K. (Khadeeja), Mulder, R. H. (Rosa H.), Hafferty, J. D. (Jonathan D.), Adams, M. J. (Mark J.), Walker, R. M. (Rosie M.), Morris, S. W. (Stewart W.), Lahti, J. (Jari), Kupers, L. K. (Leanne K.), Escaramis, G. (Georgia), Alemany, S. (Silvia), Bonder, M. J. (Marc Jan), Meijer, M. (Mandy), Ip, H. F. (Hill F.), Jansen, R. (Rick), Baselmans, B. M. (Bart M. L.), Parmar, P. (Priyanka), Lowry, E. (Estelle), Streit, F. (Fabian), Sirignano, L. (Lea), Send, T. S. (Tabea S.), Frank, J. (Josef), Jylhava, J. (Juulia), Wang, Y. (Yunzhang), Mishra, P. P. (Pashupati Prasad), Colins, O. F. (Olivier F.), Corcoran, D. L. (David L.), Poulton, R. (Richie), Mill, J. (Jonathan), Hannon, E. (Eilis), Arseneault, L. (Louise), Korhonen, T. (Tellervo), Vuoksimaa, E. (Eero), Felix, J. F. (Janine F.), Bakermans-Kranenburg, M. J. (Marian J.), Campbell, A. (Archie), Czamara, D. (Darina), Binder, E. (Elisabeth), Corpeleijn, E. (Eva), Gonzalez, J. R. (Juan R.), Grazuleviciene, R. (Regina), Gutzkow, K. B. (Kristine B.), Evandt, J. (Jorunn), Vafeiadi, M. (Marina), Klein, M. (Marieke), van der Meer, D. (Dennis), Ligthart, L. (Lannie), Kluft, C. (Cornelis), Davies, G. E. (Gareth E.), Hakulinen, C. (Christian), Keltikangas-Jarvinen, L. (Liisa), Franke, B. (Barbara), Freitag, C. M. (Christine M.), Konrad, K. (Kerstin), Hervas, A. (Amaia), Fernandez-Rivas, A. (Aranzazu), Vetro, A. (Agnes), Raitakari, O. (Olli), Lehtimaki, T. (Terho), Vermeiren, R. (Robert), Strandberg, T. (Timo), Raikkonen, K. (Katri), Snieder, H. (Harold), Witt, S. H. (Stephanie H.), Deuschle, M. (Michael), Pedersen, N. L. (Nancy L.), Hagg, S. (Sara), Sunyer, J. (Jordi), Franke, L. (Lude), Kaprio, J. (Jaakko), Ollikainen, M. (Miina), Moffitt, T. E. (Terrie E.), Tiemeier, H. (Henning), van IJzendoorn, M. H. (Marinus H.), Relton, C. (Caroline), Vrijheid, M. (Martine), Sebert, S. (Sylvain), Järvelin, M.-R. (Marjo-Riitta), Caspi, A. (Avshalom), Evans, K. L. (Kathryn L.), McIntosh, A. M. (Andrew M.), Bartels, M. (Meike), and Boomsma, D. I. (Dorret, I)

Abstract

DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of epigenome-wide association studies (EWAS) of aggressive behavior (N = 15,324 participants). In peripheral blood samples of 14,434 participants from 18 cohorts with mean ages ranging from 7 to 68 years, 13 methylation sites were significantly associated with aggression (alpha = 1.2 × 10−7; Bonferroni correction). In cord blood samples of 2425 children from five cohorts with aggression assessed at mean ages ranging from 4 to 7 years, 83% of these sites showed the same direction of association with childhood aggression (r = 0.74, p = 0.006) but no epigenome-wide significant sites were found. Top-sites (48 at a false discovery rate of 5% in the peripheral blood meta-analysis or in a combined meta-analysis of peripheral blood and cord blood) have been associated with chemical exposures, smoking, cognition, metabolic traits, and genetic variation (mQTLs). Three genes whose expression levels were associated with top-sites were previously linked to schizophrenia and general risk tolerance. At six CpGs, DNA methylation variation in blood mirrors variation in the brain. On average 44% (range = 3–82%) of the aggression–methylation association was explained by current and former smoking and BMI. These findings point at loci that are sensitive to chemical exposures with potential implications for neuronal functions. We hope these results to be a starting point for studies leading to applications as peripheral biomarkers and to reveal causal relationships with aggression and related traits.

Published
2021

18. Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age – An exposome-based approach in 5 European cohorts

Author

Jedynak, P., Maitre, L., Guxens, M., Gutzkow, K.B., Julvez, J., Lopez-Vicente, M., Sunyer, J., Casas, M., Chatzi, L., Grazuleviciene, R., Kampouri, M., McEachan, R., Mon-Williams, M., Tamayo, I., Thomsen, C., Urquiza, J., Vafeiadi, M., Wright, J., Basagana, X., Vrijheid, M., Philippat, C., Child and Adolescent Psychiatry / Psychology, RS: NUTRIM - R3 - Respiratory & Age-related Health, Complexe Genetica, and VDU CRIS

Subjects
Prenatalinė ekspozicija, Child behaviour, BISPHENOL-A EXPOSURE, Strengths and Difficulties Questionnaire, internal exposome, COPPER, birth cohort, organophosphate pesticide exposure, imputation, prenatal exposure, HYPERACTIVITY, persistent organic pollutants, inner-city children, VARIABLE SELECTION, Vidinė ekspozicija, DEVELOPMENTAL NEUROTOXICITY, neuropsychological development, Vaiko elgesys
Abstract

Background: Studies looking at associations between environmental chemicals and child behaviour usually consider only one exposure or family of exposures.Objective: This study explores associations between prenatal exposure to a wide range of environmental chemicals and child behaviour.Methods: We studied 703 mother-child pairs from five European cohorts recruited in 2003-2009 We assessed 47 exposure biomarkers from eight chemical exposure families in maternal blood or urine collected during pregnancy. We used the Strengths and Difficulties Questionnaire (SDQ) to evaluate child behaviour between three and seven years of age. We assessed associations of SDQ scores with exposures using an adjusted least absolute shrinkage and selection operator (LASSO) considering all exposures simultaneously and an adjusted exposome-wide association study (ExWAS) considering each exposure independently.Results: LASSO selected only copper (Cu) as associated with externalizing behaviour. In the ExWAS, bisphenol A [BPA, incidence rate ratio (IRR): 1.06, 95% confidence interval (95%CI): 1.01; 1.12] and mono-n-butyl phthalate (MnBP, IRR: 1.06, 95%CI: 1.00; 1.13) were associated with greater risk of externalizing behaviour problems. Cu (IRK: 0.90, 95%CI: 0.82; 0.98), perfluoroundecanoate (PFUnDA, IRR: 0.92, 95%CI: 0.84;0.99) and organochlorine compounds (OCs) were associated with lower risk of externalizing behaviour problems, however the associations with OCs were mainly seen among women with insufficient weight gain during pregnancy. Internalizing score worsen in association with exposure to diethyl thiophosphate (DETP, IRR: 1.11, 95%CI: 1.00;124) but the effect was driven by the smallest cohort. Internalizing score improved with increased concentration of perfluorooctane sulfonate (PFOS, IRR: 0.92, 95%CI: 0.85;1.00), however the association was driven by the two smallest cohorts with the lowest PFOS concentrations.Discussion: This study added evidence on deleterious effects of prenatal exposure to BPA and MnBP on child behaviour. Other associations should be interpreted cautiously since they were not consistent with previous studies or they have not been studied extensively. (C) 2020 The Authors. Published by Elsevier B.V.

Published
2021

19. Trihalomethanes in drinking water and bladder cancer burden in the European Union

Author

Evlampidou, I. (Iro), Font-Ribera, L. (Laia), Rojas-Rueda, D. (David), Gracia-Lavedan, E. (Esther), Costet, N. (Nathalie), Pearce, N. (Neil), Vineis, P. (Paolo), Jaakkola, J. J. (Jouni J. K.), Delloye, F. (Francis), Makris, K. C. (Konstantinos C.), Stephanou, E. G. (Euripides G.), Kargaki, S. (Sophia), Kozisek, F. (Frantisek), Sigsgaard, T. (Torben), Hansen, B. (Birgitte), Schullehner, J. (Jörg), Nahkur, R. (Ramon), Galey, C. (Catherine), Zwiener, C. (Christian), Vargha, M. (Marta), Righi, E. (Elena), Aggazzotti, G. (Gabriella), Kalnina, G. (Gunda), Grazuleviciene, R. (Regina), Polanska, K. (Kinga), Gubkova, D. (Dasa), Bitenc, K. (Katarina), Goslan, E. H. (Emma H.), Kogevinas, M. (Manolis), Villanueva, C. M. (Cristina M.), Evlampidou, I. (Iro), Font-Ribera, L. (Laia), Rojas-Rueda, D. (David), Gracia-Lavedan, E. (Esther), Costet, N. (Nathalie), Pearce, N. (Neil), Vineis, P. (Paolo), Jaakkola, J. J. (Jouni J. K.), Delloye, F. (Francis), Makris, K. C. (Konstantinos C.), Stephanou, E. G. (Euripides G.), Kargaki, S. (Sophia), Kozisek, F. (Frantisek), Sigsgaard, T. (Torben), Hansen, B. (Birgitte), Schullehner, J. (Jörg), Nahkur, R. (Ramon), Galey, C. (Catherine), Zwiener, C. (Christian), Vargha, M. (Marta), Righi, E. (Elena), Aggazzotti, G. (Gabriella), Kalnina, G. (Gunda), Grazuleviciene, R. (Regina), Polanska, K. (Kinga), Gubkova, D. (Dasa), Bitenc, K. (Katarina), Goslan, E. H. (Emma H.), Kogevinas, M. (Manolis), and Villanueva, C. M. (Cristina M.)

Abstract

Background: Trihalomethanes (THMs) are widespread disinfection by-products (DBPs) in drinking water, and long-term exposure has been consistently associated with increased bladder cancer risk. Objective: We assessed THM levels in drinking water in the European Union as a marker of DBP exposure and estimated the attributable burden of bladder cancer. Methods: We collected recent annual mean THM levels in municipal drinking water in 28 European countries (EU28) from routine monitoring records. We estimated a linear exposure–response function for average residential THM levels and bladder cancer by pooling data from studies included in the largest international pooled analysis published to date in order to estimate odds ratios (ORs) for bladder cancer associated with the mean THM level in each country (relative to no exposure), population-attributable fraction (PAF), and number of attributable bladder cancer cases in different scenarios using incidence rates and population from the Global Burden of Disease study of 2016. Results: We obtained 2005–2018 THM data from EU26, covering 75% of the population. Data coverage and accuracy were heterogeneous among countries. The estimated population-weighted mean THM level was 11.7μg/L [standard deviation (SD) of 11.2]. The estimated bladder cancer PAF was 4.9% [95% confidence interval (CI): 2.5, 7.1] overall (range: 0–23%), accounting for 6,561 (95% CI: 3,389, 9,537) bladder cancer cases per year. Denmark and the Netherlands had the lowest PAF (0.0% each), while Cyprus (23.2%), Malta (17.9%), and Ireland (17.2%) had the highest among EU26. In the scenario where no country would exceed the current EU mean, 2,868 (95% CI: 1,522, 4,060; 43%) annual attributable bladder cancer cases could potentially be avoided. Discussion: Efforts have been made to reduce THM levels in the European Union. However, assuming a causal association, current levels in certain countries still could lead to a considerable burden of bladder cancer

Published
2020

20. Prenatal exposure to mercury and risk of pediatric liver injury

Author

Stratakis, N., primary, Margetaki, K., additional, Conti, D.V., additional, Garcia, E., additional, Grazuleviciene, R., additional, Maitre, L., additional, Slama, R., additional, Thomsen, C., additional, Vafeiadi, M., additional, Valvi, D., additional, Wright, J., additional, Zhao, Y., additional, Vos, M.B., additional, Vrijheid, M., additional, Berhane, K., additional, McConnell, R., additional, and Chatzi, L., additional

Published
2020
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21. Prenatal Exposure to Air Pollution and Traffic and the Risk of Child Liver Injury in European Children-The HELIX Project

Author

Garcia, E., primary, Stratakis, N., additional, Valvi, D., additional, Maitre, L., additional, Varo, N., additional, Basagana, X., additional, de Castro, M., additional, Fossati, S., additional, Grazuleviciene, R., additional, Haug, L.S., additional, Heude, B., additional, McEachan, R., additional, Nieuwenhuijsen, M., additional, Papadopoulou, E., additional, Roumeliotaki, T., additional, Slama, R., additional, Urquiza, J., additional, Vafeiadi, M., additional, Vos, M.B., additional, Wright, J., additional, Conti, D.V., additional, Berhane, K., additional, Chatzi, M., additional, McConnell, R., additional, and Chatzi, L., additional

Published
2020
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25. Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis

Author

Gruzieva, O. (Olena), Xu, C.-J. (Cheng-Jian), Yousefi, P. (Paul), Relton, C.L. (Caroline), Merid, S.K. (Simon Kebede), Breton, C. (Carrie), Gao, L. (Lu), Volk, H.E. (Heather E.), Feinberg, J.I. (Jason I.), Ladd-Acosta, C. (Christine), Bakulski, K. (Kelly), Auffray, C. (C.), Lemonnier, N. (Nathanaël), Plusquin, M. (Michelle), Ghantous, A. (Akram), Herceg, Z. (Zdenko), Nawrot, T.S. (Tim S.), Pizzi, C. (Costanza), Richiardi, L. (Lorenzo), Rusconi, F. (Franca), Vineis, P. (Paolo), Kogevinas, M. (Manolis), Felix, J.F. (Janine), Duijts, L. (Liesbeth), Dekker, H.T. (Herman) den, Jaddoe, V.W.V. (Vincent), Ruiz, J.L. (José L), Bustamante, M. (Mariona), Anto, J.M. (Josep), Sunyer, J. (Jordi), Vrijheid, M. (Martine), Gutzkow, K.B. (Kristine B.), Grazuleviciene, R. (Regina), Hernandez-Ferrer, C. (Carles), Annesi-Maesano, I. (Isabella), Lepeule, J. (Johanna), Bousquet, J. (Jean), Bergström, A. (Anna), Kull, C.A. (Christian), Söderhäll, C. (Cilla), Kere, J. (Juha), Gehring, U. (Ulrike), Brunekreef, B. (Bert), Just, A.C. (Allan C.), Wright, R.J. (Rosalind J.), Peng, C. (Cheng), Gold, D.R. (Diane), Kloog, I. (Itai), Demeo, D.L. (Dawn), Pershagen, G. (Göran), Koppelman, G.H. (Gerard), London, S.J. (Stephanie J.), Baccarelli, A.A. (Andrea), Melén, E. (Erik), Gruzieva, O. (Olena), Xu, C.-J. (Cheng-Jian), Yousefi, P. (Paul), Relton, C.L. (Caroline), Merid, S.K. (Simon Kebede), Breton, C. (Carrie), Gao, L. (Lu), Volk, H.E. (Heather E.), Feinberg, J.I. (Jason I.), Ladd-Acosta, C. (Christine), Bakulski, K. (Kelly), Auffray, C. (C.), Lemonnier, N. (Nathanaël), Plusquin, M. (Michelle), Ghantous, A. (Akram), Herceg, Z. (Zdenko), Nawrot, T.S. (Tim S.), Pizzi, C. (Costanza), Richiardi, L. (Lorenzo), Rusconi, F. (Franca), Vineis, P. (Paolo), Kogevinas, M. (Manolis), Felix, J.F. (Janine), Duijts, L. (Liesbeth), Dekker, H.T. (Herman) den, Jaddoe, V.W.V. (Vincent), Ruiz, J.L. (José L), Bustamante, M. (Mariona), Anto, J.M. (Josep), Sunyer, J. (Jordi), Vrijheid, M. (Martine), Gutzkow, K.B. (Kristine B.), Grazuleviciene, R. (Regina), Hernandez-Ferrer, C. (Carles), Annesi-Maesano, I. (Isabella), Lepeule, J. (Johanna), Bousquet, J. (Jean), Bergström, A. (Anna), Kull, C.A. (Christian), Söderhäll, C. (Cilla), Kere, J. (Juha), Gehring, U. (Ulrike), Brunekreef, B. (Bert), Just, A.C. (Allan C.), Wright, R.J. (Rosalind J.), Peng, C. (Cheng), Gold, D.R. (Diane), Kloog, I. (Itai), Demeo, D.L. (Dawn), Pershagen, G. (Göran), Koppelman, G.H. (Gerard), London, S.J. (Stephanie J.), Baccarelli, A.A. (Andrea), and Melén, E. (Erik)

Abstract

BACKGROUND: Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes. OBJECTIVES: We aimed to investigate associations between prenatal exposure to particulate matter (PM) with diameter [Formula: see text] ([Formula: see text]) or [Formula: see text] ([Formula: see text]) and DNA methylation in newborns and children. METHODS: We meta-analyzed associations between exposure to [Formula: see text] ([Formula: see text]) and [Formula: see text] ([Formula: see text]) at maternal home addresses during pregnancy and newborn DNA methylation assessed by Illumina Infinium HumanMethylation450K BeadChip in nine European and American studies, with replication in 688 independent newborns and look-up analyses in 2,118 older children. We used two approaches, one focusing on single cytosine-phosphate-guanine (CpG) sites and another on differentially methylated regions (DMRs). We also related PM exposures to blood mRNA expression. RESULTS: Six CpGs were significantly associa

Published
2019
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26. Prenatal particulate air pollution and DNA methylation in newborns: An epigenome-wide meta-analysis

Author

Gruzieva, O., Xu, Cheng-Jian, Yousefi, P., Relton, C., Merid, S. K., Breton, C. V., Gao, L., Volk, H. E., Feinberg, J. I., Ladd-Acosta, C., Bakulski, K., Auffray, C., Lemonnier, N., Plusquin, M., Ghantous, A., Herceg, Z., Nawrot, T. S., Pizzi, C., Richiardi, L., Rusconi, Franca, Vineis, P., Kogevinas, M., Felix, Janine F, Duijts, L., Den Dekker, H. T., Jaddoe, V. W. V., Ruiz, José L., Bustamante, M., Antó, Josep M., Sunyer, J., Vrijheid, M., Gutzkow, K.B., Grazuleviciene, R., Hernandez-Ferrer, C., Annesi-Maesano, I., Lepeule, J., Bousquet, J., Bergström, A., Kull, I., Söderhäll, C., Kere, J., Gehring, U., Brunekreef, B., Just, A.C., Wright, R.J., Peng, C., Gold, D.R., Kloog, I., Demeo, D.L., Gruzieva, O., Xu, Cheng-Jian, Yousefi, P., Relton, C., Merid, S. K., Breton, C. V., Gao, L., Volk, H. E., Feinberg, J. I., Ladd-Acosta, C., Bakulski, K., Auffray, C., Lemonnier, N., Plusquin, M., Ghantous, A., Herceg, Z., Nawrot, T. S., Pizzi, C., Richiardi, L., Rusconi, Franca, Vineis, P., Kogevinas, M., Felix, Janine F, Duijts, L., Den Dekker, H. T., Jaddoe, V. W. V., Ruiz, José L., Bustamante, M., Antó, Josep M., Sunyer, J., Vrijheid, M., Gutzkow, K.B., Grazuleviciene, R., Hernandez-Ferrer, C., Annesi-Maesano, I., Lepeule, J., Bousquet, J., Bergström, A., Kull, I., Söderhäll, C., Kere, J., Gehring, U., Brunekreef, B., Just, A.C., Wright, R.J., Peng, C., Gold, D.R., Kloog, I., and Demeo, D.L.

Abstract

BACKGROUND: Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes. OBJECTIVES: We aimed to investigate associations between prenatal exposure to particulate matter (PM) with diameter <10 (PM)or<2:5 lm (PM) and DNA methylation in newborns and children. METHODS: We meta-analyzed associations between exposure to PM (n = 1,949) and PM (n = 1,551) at maternal home addresses during pregnancy and newborn DNA methylation assessed by Illumina Infinium HumanMethylation450K BeadChip in nine European and American studies, with replication in 688 independent newborns and look-up analyses in 2,118 older children. We used two approaches, one focusing on single cytosine-phosphate-guanine (CpG) sites and another on differentially methylated regions (DMRs). We also related PM exposures to blood mRNA expression. RESULTS: Six CpGs were significantly associated [false discovery rate (FDR) <0:05] with prenatal PM and 14 with PM exposure. Two of the PM-related CpGs mapped to FAM13A (cg00905156) and NOTCH4 (cg06849931) previously associated with lung function and asthma. Although these associations did not replicate in the smaller newborn sample, both CpGs were significant (p <0:05) in 7-to 9-y-olds. For cg06849931, however, the direction of the association was inconsistent. Concurrent PM exposure was associated with a significantly higher NOTCH4 expression at age 16 y. We also identified several DMRs associated with either prenatal PM and or PM exposure, of which two PM-related DMRs, including H19 and MARCH11, replicated in newborns. CONCLUSIONS: Several differentially methylated CpGs and DMRs associated with prenatal PM exposure were identified in newborns, with annotation to genes previously implicated in lung-related outcomes. https://doi.org/10.1289/EHP4522.

Published
2019

28. The influence of meteorological factors and atmospheric pollutants on the risk of preterm birth

Author

Giorgis-Allemand, L. (Lise), Pedersen, M. (Marie), Bernard, C. (Claire), Aguilera, I. (Inmaculada), Beelen, R.M.J. (Rob), Chatzi, L. (Leda), Cirach, M. (Marta), Danileviciute, A. (Asta), Dedele, A. (Audrius), Eijsden, M. (Manon) van, Estarlich, M. (Marisa), Fernández-Somoano, A. (Ana), Fernandez, M.F. (Mariana), Forastiere, F. (Francesco), Gehring, U. (Ulrike), Grazuleviciene, R. (Regina), Gruzieva, O. (Olena), Heude, B. (Barbara), Hoek, G. (Gerard), De Hoogh, K. (Kees), Hooven, E.H. (Edith) van den, Håberg, S.E. (Siri E), Iñiguez, A. (Andrés), Jaddoe, V.W.V. (Vincent), Korek, M. (Michal), Lertxundi, A. (Aitana), Lepeule, J. (Johanna), Nafstad, P. (Per), Nystad, W. (Wenche), Patelarou, E. (Evridiki), Porta, D. (Daniela), Postma, D.S. (Dirkje), Raaschou-Nielsen, O. (Ole), Rudnai, P. (Peter), Siroux, V. (V.), Sunyer, J. (Jordi), Stephanou, E.G. (Euripides), Sørensen, M. (Mette), Thorup Eriksen, K. (Kirsten), Tuffnell, D. (Derek), Varró, M.J. (Mihály), Vrijkotte, T.G.M. (Tanja), Wijga, A.H. (Alet), Wright, J. (Juliet), Nieuwenhuijsen, M. (Mark), Pershagen, G. (Göran), Brunekreef, B. (Bert), Kogevinas, M. (Manolis), Slama, R. (Rémy), Giorgis-Allemand, L. (Lise), Pedersen, M. (Marie), Bernard, C. (Claire), Aguilera, I. (Inmaculada), Beelen, R.M.J. (Rob), Chatzi, L. (Leda), Cirach, M. (Marta), Danileviciute, A. (Asta), Dedele, A. (Audrius), Eijsden, M. (Manon) van, Estarlich, M. (Marisa), Fernández-Somoano, A. (Ana), Fernandez, M.F. (Mariana), Forastiere, F. (Francesco), Gehring, U. (Ulrike), Grazuleviciene, R. (Regina), Gruzieva, O. (Olena), Heude, B. (Barbara), Hoek, G. (Gerard), De Hoogh, K. (Kees), Hooven, E.H. (Edith) van den, Håberg, S.E. (Siri E), Iñiguez, A. (Andrés), Jaddoe, V.W.V. (Vincent), Korek, M. (Michal), Lertxundi, A. (Aitana), Lepeule, J. (Johanna), Nafstad, P. (Per), Nystad, W. (Wenche), Patelarou, E. (Evridiki), Porta, D. (Daniela), Postma, D.S. (Dirkje), Raaschou-Nielsen, O. (Ole), Rudnai, P. (Peter), Siroux, V. (V.), Sunyer, J. (Jordi), Stephanou, E.G. (Euripides), Sørensen, M. (Mette), Thorup Eriksen, K. (Kirsten), Tuffnell, D. (Derek), Varró, M.J. (Mihály), Vrijkotte, T.G.M. (Tanja), Wijga, A.H. (Alet), Wright, J. (Juliet), Nieuwenhuijsen, M. (Mark), Pershagen, G. (Göran), Brunekreef, B. (Bert), Kogevinas, M. (Manolis), and Slama, R. (Rémy)

Abstract

Atmospheric pollutants and meteorological conditions are suspected to be causes of preterm birth. We aimed to characterize their possible association with the risk of preterm birth (defined as birth occurring before 37 completed gestational weeks). We pooled individual data from 13 birth cohorts in 11 European countries (71,493 births from the period 1994-2011, European Study of Cohorts for Air Pollution Effects (ESCAPE)). City-specific meteorological data from routine monitors were averaged over time windows spanning from 1 week to the whole pregnancy. Atmospheric pollution measurements (nitrogen oxides and particulate matter) were combined with data from permanent monitors and land-use data into seasonally adjusted land-use regression models. Preterm birth risks associ

Published
2017
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29. Pooling birth cohorts in allergy and asthma: European union-funded initiatives-a MeDALL, CHICOS, ENRIECO, and GALEN joint paper: CHICOS study group ENRIECO study group GA2LEN study group

Author

Bousquet, Jean, Anto, Josep, Sunyer, Jordi, Nieuwenhuijsen, Mark, Vrijheid, Martine, Keil, Thomas, Akdis, M., Auffray, C., Postma, D. S., Valenta, R., Haahtela, T., Cambon-Thomsen, A., Lambrecht, B. N., Akdis, C. A., Annesi-Maesano, I., Arno, A., Bachert, C., Ballester, F., Basagana, X., Baumgartner, U., Bindslev-Jensen, C., Brunekreef, B., Chatzi, L., Eller, E., Forastiere, F., Garcia-Aymerich, J., Guerra, S., Gehring, U., Hammad, H., Heinrich, J., Hohmann, C., Kauffmann, F., Kerkhof, M., Kogevinas, M., Koppelman, G. H., Kowalski, M. L., Kull, I., Lau, S., Lodrup-Carlsen, K. C., Lupinek, C., Maier, D., Makela, M. J., Martinez, F. D., Momas, I., Nawijn, M. C., Neubauer, A., Oddie, S., Palkonen, S., Reitamo, S., Rial-Sebbag, E., Salapatas, M., Siroux, V., Smagghe, D., Smit, H. A., Torrent, M., Toskala, E., van Oosterhout, A. J. M., Varaso, R., von Hertzen, L., Wickman, M., Wijmenga, C., Zuberbier, T., Burney, P. G., Van Cauwenberge, P., Bonini, S., Fokkens, W. J., Kramer, U., Mullol, J., Nizankowska-Mogilnicka, E., Papadopoulos, N., Alm, B., Alm, J., Arshad, S. H., Bravi, F., Canonica, G. W., Custovic, A., Dubakiene, R., Fantini, M. P., Gjomarkaj, M., Halken, S., Host, A., Howarth, P., Kuehni, C., Lotvall, J., Mommers, M., Porta, D., Radon, K., Ring, J., Roberts, G., Schünemann, H. J., Simpson, A., Szczecklik, A., Thijs, C., Todo-Bom, A., Valovirta, E., van Steen, K., Von Berg, A., von Mutius, E., Wahn, U., Wennergren, G., Wijga, A. H., Zock, J. P., Duijts, L., Jaddoe, V., Lawlor, D., Lucas, P., Magnus, P., Merletti, F., Nybo Andersen, A. M., Raat, H., Stoltenberg, C., Casas, M., Bergström, A., Carmichael, A., Chen, C. -M., Cordier, S., Eggesbø, M., Fernández, M. F., Fernández-Somoano, A., Grazuleviciene, R., Karvonen, A. M., Koppen, G., Krämer, U., Kuehni, C. E., Majewska, R., Patelarou, E., Skaalum Petersen, M., Pierik, F. H., Polanska, K., Richiardi, L., Santos, A. C., Slama, R., Sram, R. J., Tischer, C., Toft, G., Trnovec, T., Vandentorren, S., Vardavas, C., Vrijkotte, T. G. M., Wilhelm, M., Bousquet, Jean, Anto, Josep, Sunyer, Jordi, Nieuwenhuijsen, Mark, Vrijheid, Martine, Keil, Thoma, Akdis, M., Auffray, C., Postma, D.S., Valenta, R., Haahtela, T., Cambon-Thomsen, A., Lambrecht, B.N., Akdis, C.A., Annesi-Maesano, I., Arno, A., Bachert, C., Ballester, F., Basagana, X., Baumgartner, U., Bindslev-Jensen, C., Brunekreef, B., Chatzi, L., Eller, E., Forastiere, F., Garcia-Aymerich, J., Guerra, S., Gehring, U., Hammad, H., Heinrich, J., Hohmann, C., Kauffmann, F., Kerkhof, M., Kogevinas, M., Koppelman, G.H., Kowalski, M.L., Kull, I., Lau, S., Lodrup-Carlsen, K.C., Lupinek, C., Maier, D., Makela, M.J., Martinez, F.D., Momas, I., Nawijn, M.C., Neubauer, A., Oddie, S., Palkonen, S., Reitamo, S., Rial-Sebbag, E., Salapatas, M., Siroux, V., Smagghe, D., Smit, H.A., Torrent, M., Toskala, E., van Oosterhout, A.J.M., Varaso, R., von Hertzen, L., Wickman, M., Wijmenga, C., Zuberbier, T., Burney, P.G., Van Cauwenberge, P., Bonini, S., Fokkens, W.J., Kramer, U., Mullol, J., Nizankowska-Mogilnicka, E., Papadopoulos, N., Alm, B., Alm, J., Arshad, S.H., Bravi, F., Canonica, G.W., Custovic, A., Dubakiene, R., Fantini, M.P., Gjomarkaj, M., Halken, S., Host, A., Howarth, P., Kuehni, C., Lotvall, J., Mommers, M., Porta, D., Radon, K., Ring, J., Roberts, G., Schünemann, H.J., Simpson, A., Szczecklik, A., Thijs, C., Todo-Bom, A., Valovirta, E., van Steen, K., Von Berg, A., von Mutius, E., Wahn, U., Wennergren, G., Wijga, A.H., Zock, J.P., Duijts, L., Jaddoe, V., Lawlor, D., Lucas, P., Magnus, P., Merletti, F., Nybo Andersen, A.M., Raat, H., Stoltenberg, C., Casas, M., Bergström, A., Carmichael, A., Chen, C.-M., Cordier, S., Eggesbø, M., Fernández, M.F., Fernández-Somoano, A., Grazuleviciene, R., Karvonen, A.M., Koppen, G., Krämer, U., Kuehni, C.E., Majewska, R., Patelarou, E., Skaalum Petersen, M., Pierik, F.H., Polanska, K., Richiardi, L., Santos, A.C., Slama, R., Sram, R.J., Tischer, C., Toft, G., Trnovec, T., Vandentorren, S., Vardavas, C., Vrijkotte, T.G.M., and Wilhelm, M.

Subjects
Allergy, Risk Factor, Immunology, CHICOS, Longitudinal Studie, Environmental Exposure, Asthma, Europe, MeDALL, ENRIECO, Hypersensitivity, Multicenter Studies as Topic, Immunology and Allergy, European Union, Cohort Studie, Birth cohort, Human
Abstract

Long-term birth cohort studies are essential to understanding the life course and childhood predictors of allergy and the complex interplay between genes and the environment (including lifestyle and socioeconomic determinants). Over 100 cohorts focusing on asthma and allergy have been initiated in the world over the past 30 years. Since 2004, several research initiatives funded under the EU Framework Program for Research and Technological Development FP6-FP7 have attempted to identify, compare, and evaluate pooling data from existing European birth cohorts (GA2LEN: Global Allergy and European Network, FP6; ENRIECO: Environmental Health Risks in European Birth Cohorts, FP7; CHICOS: Developing a Child Cohort Research Strategy for Europe, FP7; MeDALL: Mechanisms of the Development of ALLergy, FP7). However, there is a general lack of knowledge about these initiatives and their potentials. The aim of this paper is to review current and past EU-funded projects in order to make a summary of their goals and achievements and to suggest future research needs of these European birth cohort networks. © 2012 S. Karger AG, Basel.

Published
2013

30. European birth cohorts for environmental health research

Author

Vrijheid, M., Casas, M., Bergström, A., Carmichael, A., Cordier, S., Eggesbø, M., Eller, E., Fantini, M.P., Fernández, M.F., Fernández-Somoano, A., Gehring, U., Grazuleviciene, R., Hohmann, C., Karvonen, A.M., Keil, T., Kogevinas, M., Koppen, G., Krämer, U., Kuehni, C.E., Magnus, P., Majewska, R., Andersen, A., Patelarou, E., Petersen, M., Pierik, F.H., Polanska, K., Porta, D., Richiardi, L., Santos, A, Slama, R., Sram, R.J., Thijs, C., Tischer, C., Toft, G., Trnovec, T., Vandentorren, S., Vrijkotte, T.G.M., Wilhelm, M., Wright, J., Nieuwenhuijsen, M., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Vrijheid M., Casas M., Bergström A., Carmichael A., Cordier S., Eggesbø M., Eller E., Fantini M.P., Fernández M.F., Fernández-Somoano A., Gehring U., Grazuleviciene R., Hohmann C., Karvonen A.M., Keil T., Kogevinas M., Koppen G., Krämer U., Kuehni C., Magnus P., Majewska R., Andersen A.M., Patelarou E., Petersen M.S., Pierik F.H., Polanska K., Porta D., Richiardi L., Santos A.C., Slama R., Sram R.J., Thijs C., Tischer C., Toft G., Trnovec T., Vandentorren S., Vrijkotte T.G., Wilhelm M., Wright J., Nieuwenhuijsen M., Le Corre, Morgane, IMIM-Hospital del Mar, Generalitat de Catalunya, Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Spanish Consortium for Research on Epidemiology and Public Health, CIBER de Epidemiología y Salud Pública (CIBERESP), Institute of Environmental Medicine, Karolinska Institutet [Stockholm]-Sachs' Children's Hospital, School of Social and Community Medicine, University of Bristol [Bristol], Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Division of Epidemiology, Norwegian Institute of Public Health [Oslo] (NIPH), Department of Dermatology and Allergy Centre, Odense University Hospital, Department of Public Health, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Risk Assessment Sciences Institute, Utrecht University [Utrecht], Vytautas Magnus University - Vytauto Didziojo Universitetas (VDU), Institute of Social Medicine, Epidemiology and Health Economics-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Department of Environmental Health, National Institute for Health and Welfare [Helsinki], Environmental Risk and Health Unit, Flemish Institute for Technological Research (VITO), IUF, Leibniz Research Institute for Environmental Medicine (IUF), Institute of Social and Preventive Medicine (ISPM), University of Bern, Epidemiology and Preventive Medicine, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Section of Social Medicine, Department of Public Health [Copenhagen], Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH)-Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Department of Social Medicine, University of Crete [Heraklion] (UOC)-Medical School, Department of Occupational Medicine and Public Health, The Faroese Hospital System (Landssjúkrahúsið) (LS), Department of Urban Environment, The Netherlands Organisation for Applied Scientific Research (TNO), Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Department of Epidemiology, Regional Health Service - Lazio, Cancer Epidemiology Unit, Université de Turin-CPO-Piemonte, Department of Hygiene and Epidemiology, Universidade do Porto = University of Porto, Environmental Epidemiology Applied to Reproduction and Respiratory Health, Epidémiologie pronostique des cancers et affections graves, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute of Experimental Medicine AS CR, Maastricht University [Maastricht]-School for Public Health and Primary Care (CAPHRI), Institute of Epidemiology [Neuherberg] (EPI), German Research Center for Environmental Health - Helmholtz Center München (GmbH), Department of Occupational Medicine, Aarhus University Hospital, Slovak Medical University of Bratislava (SMU), Institut de Veille Sanitaire (INVS), Academic Medical Centre, Hygiene, Social and Environmental Medicine, Ruhr University Bochum (RUB), Bradford Institute for Health Research, Environmental Health Risks in European Birth Cohorts (ENRIECO), the European Union's Seventh Framework Programme (Theme 6, Environment, including climate change), grant agreement 226285., Epidemiologie, RS: CAPHRI School for Public Health and Primary Care, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]-Epidemiology and Health Economics, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU)-Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Universidade do Porto-University of Porto Medical School and Institute of Public Health, and Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK (BIHR)

Subjects
Passive smoking, Databases, Factual, Health, Toxicology and Mutagenesis, Review, 010501 environmental sciences, Medi ambient -- Anàlisi d'impacte, medicine.disease_cause, 01 natural sciences, birth cohorts, child health, environmental exposures, Europe, review, Cohort Studies, MESH: Pregnancy, 0302 clinical medicine, Salut ambiental, Pregnancy, MESH: Child, 030212 general & internal medicine, MESH: Maternal Exposure, Child, MESH: Cohort Studies, Child health, Birth cohorts, MESH: Infant, Newborn, Environmental exposure, MESH: Infant, 3. Good health, MESH: Internet, Maternal Exposure, UES - Urban Environment & Safety, Child, Preschool, Female, EELS - Earth, Environmental and Life Sciences, Environmental Health, Cohort study, Earth & Environment, MESH: Environmental Exposure, Energy / Geological Survey Netherlands, MEDLINE, 610 Medicine & health, Environment, 03 medical and health sciences, Environmental health, medicine, Humans, Infants -- Salut i higiene, 0105 earth and related environmental sciences, Asthma, Internet, MESH: Humans, business.industry, MESH: Child, Preschool, Environmental exposures, Public Health, Environmental and Occupational Health, Infant, Newborn, Infant, Environmental Exposure, medicine.disease, MESH: Databases, Factual, Obesity, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Causal inference, MESH: Environmental Health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe, business, MESH: Female
Abstract

This work was supported by Environmental Health Risks in European Birth Cohorts (ENRIECO), a project conducted within the European Union’s Seventh Framework Programme (Theme 6, Environment, including climate change), grant agreement 226285., Vrijheid, M., Casas, M., Bergström, A., Carmichael, A., Cordier, S., Eggesbø, M., Eller, E., Fantini, M.P., Fernández, M.F., Fernández-Somoano, A., Gehring, U., Grazuleviciene, R., Hohmann, C., Karvonen, A.M., Keil, T., Kogevinas, M., Koppen, G., Krämer, U., Kuehni, C.E., Magnus, P., Majewska, R., Andersen, A.-M.N., Patelarou, E., Petersen, M.S., Pierik, F.H., Polanska, K., Porta, D., Richiardi, L., Santos, A.C., Slama, R., Sram, R.J., Thijs, C., Tischer, C., Toft, G., Trnovec, T., Vandentorren, S., Vrijkotte, T.G.M., Wilhelm, M., Wright, J., Nieuwenhuijsen, M.

Published
2012

31. Maternal occupation during pregnancy, birth weight, and length of gestation: Combined analysis of 13 European birth cohorts

Author

Casas, M. (Miguel), Cordier, S. (Sylvaine), Martinez, D. (David), Barros, H. (Henrique), Bonde, J.P. (Jens Peter), Burdorf, A. (Alex), Costet, N. (Nathalie), dos Santos, A.C. (Ana Cristina), Danileviciute, A. (Asta), Eggesbø, M. (Merete), Fernandez, M.F. (Mariana), Fevotte, J. (Joelle), García, A.M. (Ana M.), Grazuleviciene, R. (Regina), Hallner, E. (Eva), Hanke, W. (Wojciech), Kogevinas, M. (Manolis), Kull, C.A. (Christian), Larsen, P.S. (Pernille), Melaki, V. (Vasiliki), Monfort, C. (Christine), Nordby, K.-C. (Karl-Christian), Nybo Andersen, A.-M. (Anne-Marie), Patelarou, E. (Evridiki), Polanska, K. (Kinga), Richiardi, L. (Lorenzo), Marina, L.S. (Loreto Santa), Snijder, C.A. (Claudia), Tardón, A. (Adonina), Eijsden, M. (Manon) van, Vrijkotte, T.G.M. (Tanja), Zugna, D. (Daniela), Nieuwenhuijsen, M. (Mark), Vrijheid, M. (Martine), Casas, M. (Miguel), Cordier, S. (Sylvaine), Martinez, D. (David), Barros, H. (Henrique), Bonde, J.P. (Jens Peter), Burdorf, A. (Alex), Costet, N. (Nathalie), dos Santos, A.C. (Ana Cristina), Danileviciute, A. (Asta), Eggesbø, M. (Merete), Fernandez, M.F. (Mariana), Fevotte, J. (Joelle), García, A.M. (Ana M.), Grazuleviciene, R. (Regina), Hallner, E. (Eva), Hanke, W. (Wojciech), Kogevinas, M. (Manolis), Kull, C.A. (Christian), Larsen, P.S. (Pernille), Melaki, V. (Vasiliki), Monfort, C. (Christine), Nordby, K.-C. (Karl-Christian), Nybo Andersen, A.-M. (Anne-Marie), Patelarou, E. (Evridiki), Polanska, K. (Kinga), Richiardi, L. (Lorenzo), Marina, L.S. (Loreto Santa), Snijder, C.A. (Claudia), Tardón, A. (Adonina), Eijsden, M. (Manon) van, Vrijkotte, T.G.M. (Tanja), Zugna, D. (Daniela), Nieuwenhuijsen, M. (Mark), and Vrijheid, M. (Martine)

Abstract

Objectives We assessed whether maternal employment during pregnancy – overall and in selected occupational sectors – is associated with birth weight, small for gestational age (SGA), term low birth weight (LBW), length of gestation, and preterm delivery in a population-based birth cohort design. Methods We used data from >200 000 mother-child pairs enrolled in 13 European birth cohorts and compared employed versus non-employed women. Among employees, we defined groups of occupations representing the main sectors of employment for women where potential reproductive hazards are considered to be present. The comparison group comprised all other employed women not included in the occupational sector being assessed. We performed meta-analyses of cohort-specific estimates and explored heterogeneity. Results Employees had a lower risk of preterm delivery than non-employees [adjusted odds ratio (ORadj) 0.86, 95% confidence interval (95% CI) 0.81–0.91]. Working in most of the occupational sectors studied was not associated with adverse birth outcomes. Being employed as a nurse was associated with lower risk SGA infants (ORadj 0.91, 95% CI 0.84–0.99) whereas food industry workers had an increased risk of preterm delivery (ORadj 1.50, 95% CI 1.12–2.02). There was little evidence for heterogeneity between cohorts. Conclusions This study suggests that, overall, employment during pregnancy is associated with a reduction in the risk of preterm birth and that work in certain occupations may affect pregnancy outcomes. This exploratory study provides an important platform on which to base further prospective studies focused on the potential consequences of maternal occupational exposures during pregnancy on child development.

Published
2015
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32. The Effect of Park and Urban Environments on Coronary Artery Disease Patients: A Randomized Trial

Author

Grazuleviciene, R, Vencloviene, J, Kubilius, R, Grizas, V, Dedele, A, Grazulevicius, T, Ceponiene, I, Tamuleviciute-Prasciene, E, Nieuwenhuijsen, MJ, Jones, M, Gidlow, C, Grazuleviciene, R, Vencloviene, J, Kubilius, R, Grizas, V, Dedele, A, Grazulevicius, T, Ceponiene, I, Tamuleviciute-Prasciene, E, Nieuwenhuijsen, MJ, Jones, M, and Gidlow, C

Abstract

© 2015 Regina Grazuleviciene et al. Aim. To test the hypothesis that walking in a park has a greater positive effect on coronary artery disease (CAD) patients' hemodynamic parameters than walking in an urban environment. Methods. Twenty stable CAD patients were randomized into two groups: 30-minute walk on 7 consecutive days in either a city park or busy urban street. Wilcoxon signed-rank test was employed to study short-term (30 min) and cumulative changes (following 7 consecutive days of exposure) in resting hemodynamic parameters in different environments. Results. There were no statistically significant differences in the baseline and peak exercise systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), exercise duration, or HR recovery in urban versus park exposure groups. Seven days of walking slightly improved all hemodynamic parameters in both groups. Compared to baseline, the city park group exhibited statistically significantly greater reductions in HR and DBP and increases in exercise duration and HR recovery. The SBP and DBP changes in the urban exposed group were lower than in the park exposed group. Conclusions. Walking in a park had a greater positive effect on CAD patients' cardiac function than walking in an urban environment, suggesting that rehabilitation through walking in green environments after coronary events should be encouraged.

Published
2015

33. Maternal occupation during pregnancy, birth weight, and length of gestation: combined analysis of 13 European birth cohorts

Author

Casas Sanahuja, Maria, Cordier, S, Martinez, D, Barros, H, Bonde, JP, Burdorf, Lex, Costet, N, dos Santos, AC, Danileviciute, A, Eggesbo, M, Fernandez, MF, Fevotte, J, Garcia, AM, Grazuleviciene, R, Hallner, E, Hanke, W, Kogevinas, M, Kull, I, Larsen, PS, Melaki, V, Monfort, C, Nordby, KC, Andersen, AMN, Patelarou, E, Polanska, K, Richiardi, L, Marina, LS, Snijder, Claudia, Tardon, A, van Eijsden, M, Vrijkotte, TGM, Zugna, D, Nieuwenhuijsen, M, Vrijheid, M, Casas Sanahuja, Maria, Cordier, S, Martinez, D, Barros, H, Bonde, JP, Burdorf, Lex, Costet, N, dos Santos, AC, Danileviciute, A, Eggesbo, M, Fernandez, MF, Fevotte, J, Garcia, AM, Grazuleviciene, R, Hallner, E, Hanke, W, Kogevinas, M, Kull, I, Larsen, PS, Melaki, V, Monfort, C, Nordby, KC, Andersen, AMN, Patelarou, E, Polanska, K, Richiardi, L, Marina, LS, Snijder, Claudia, Tardon, A, van Eijsden, M, Vrijkotte, TGM, Zugna, D, Nieuwenhuijsen, M, and Vrijheid, M

Abstract

Objectives We assessed whether maternal employment during pregnancy overall and in selected occupational sectors - is associated with birth weight, small for gestational age (SGA), term low birth weight (LBW), length of gestation, and preterm delivery in a population-based birth cohort design. Methods We used data from >200 000 mother-child pairs enrolled in 13 European birth cohorts and compared employed versus non-employed women. Among employees, we defined groups of occupations representing the main sectors of employment for women where potential reproductive hazards are considered to be present. The comparison group comprised all other employed women not included in the occupational sector being assessed. We performed meta-analyses of cohort-specific estimates and explored heterogeneity. Results Employees had a lower risk of preterm delivery than non-employees [adjusted odds ratio (ORadj) 0.86, 95% confidence interval (95% CI) 0.81-0.91]. Working in most of the occupational sectors studied was not associated with adverse birth outcomes. Being employed as a nurse was associated with lower risk SGA infants (ORadj, 0.91, 95% CI 0.84-0.99) whereas food industry workers had an increased risk of preterm delivery (ORadj 1.50, 95% CI 1.12-2.02). There was little evidence for heterogeneity between cohorts. Conclusions This study suggests that, overall, employment during pregnancy is associated with a reduction in the risk of preterm birth and that work in certain occupations may affect pregnancy outcomes. This exploratory study provides an important platform on which to base further prospective studies focused on the potential consequences of maternal occupational exposures during pregnancy on child development.

Published
2015

34. Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes

Author

Bustamante, M. Danileviciute, A. Espinosa, A. Gonzalez, J. R. Subirana, I. Cordier, S. Chevrier, C. Chatzi, L. and Grazuleviciene, R. Sunyer, J. Ibarluzea, J. Ballester, F. and Villanueva, C. M. Nieuwenhuijsen, M. Estivill, X. and Kogevinas, M.

Abstract

Please cite this paper as: Bustamante M, Danileviciute A, Espinosa A, Gonzalez JR, Subirana I, Cordier S, Chevrier C, Chatzi L, Grazuleviciene R, Sunyer J, Ibarluzea J, Ballester F, Villanueva CM, Nieuwenhuijsen M, Estivill X, Kogevinas M. Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes. BJOG 2012;119:11411146. A nested casecontrol association study was designed to investigate the influence of maternal and fetal copy number variants (CNVs) on reproductive outcomes. Genotypes of ten CNVs encompassing GST and CYP genes were assessed. Significant associations were only found for child CNV genotypes. In particular, the child GSTM1 insertion allele was associated with prematurity protection (odds ratio, 95% CI: 0.67, 0.510.89; P < 0.01), whereas the child GSTT2B insertion allele was associated with an increased risk of being small for gestational age (odds ratio, 95% CI: 1.33, 1.071.67; P = 0.01). The study highlights the role of the fetal genome in prenatal development and also the need to analyse CNVs in a systematic manner.

Published
2012

35. Positive health effects of the natural outdoor environment in typical populations in different regions in Europe (PHENOTYPE): A study programme protocol

Author

Nieuwenhuijsen, MJ, Kruize, H, Gidlow, C, Andrusaityte, S, Antó, JM, Basagaña, X, Cirach, M, Dadvand, P, Danileviciute, A, Donaire-Gonzalez, D, Garcia, J, Jerrett, M, Jones, M, Julvez, J, Van Kempen, E, Van Kamp, I, Maas, J, Seto, E, Smith, G, Triguero, M, Wendel-Vos, W, Wright, J, Zufferey, J, Van Den Hazel, PJ, Lawrence, R, Grazuleviciene, R, Nieuwenhuijsen, MJ, Kruize, H, Gidlow, C, Andrusaityte, S, Antó, JM, Basagaña, X, Cirach, M, Dadvand, P, Danileviciute, A, Donaire-Gonzalez, D, Garcia, J, Jerrett, M, Jones, M, Julvez, J, Van Kempen, E, Van Kamp, I, Maas, J, Seto, E, Smith, G, Triguero, M, Wendel-Vos, W, Wright, J, Zufferey, J, Van Den Hazel, PJ, Lawrence, R, and Grazuleviciene, R

Abstract

Introduction: Growing evidence suggests that close contact with nature brings benefits to human health and well-being, but the proposed mechanisms are still not well understood and the associations with health remain uncertain. The Positive Health Effects of the Natural Outdoor environment in Typical Populations in different regions in Europe (PHENOTYPE) project investigates the interconnections between natural outdoor environments and better human health and well-being. Aims and methods: The PHENOTYPE project explores the proposed underlying mechanisms at work (stress reduction/restorative function, physical activity, social interaction, exposure to environmental hazards) and examines the associations with health outcomes for different population groups. It implements conventional and new innovative high-tech methods to characterise the natural environment in terms of quality and quantity. Preventive as well as therapeutic effects of contact with the natural environment are being covered. PHENOTYPE further addresses implications for land-use planning and green space management. The main innovative part of the study is the evaluation of possible short-term and long-term associations of green space and health and the possible underlying mechanisms in four different countries (each with quite a different type of green space and a different use), using the same methodology, in one research programme. This type of holistic approach has not been undertaken before. Furthermore there are technological innovations such as the use of remote sensing and smartphones in the assessment of green space. Conclusions: The project will produce a more robust evidence base on links between exposure to natural outdoor environment and human health and well-being, in addition to a better integration of human health needs into land-use planning and green space management in rural as well as urban areas.

Published
2014

36. Pregnancy and birth cohort resources in europe: a large opportunity for aetiological child health research

Author

Larsen, P.S., Kamper-Jorgensen, M., Adamson, A., Barros, H., Bonde, J.P., Brescianini, S., Brophy, S., Casas, M., Devereux, G., Eggesbo, M., Fantini, M.P., Frey, U., Gehring, U., Grazuleviciene, R., Henriksen, T.B., Hertz-Picciotto, I., Heude, B., Hryhorczuk, D.O., Inskip, H., Jaddoe, V.W., Lawlor, D.A., Ludvigsson, J., Kelleher, C., Kiess, W., Koletzko, B., Kuehni, C.E., Kull, I., Kyhl, H.B., Magnus, P., Momas, I., Murray, D., Pekkanen, J., Polanska, K., Porta, D., Poulsen, G., Richiardi, L., Roeleveld, N., Skovgaard, A.M., Sram, R.J., Strandberg-Larsen, K., Thijs, C., Eijsden, M. Van, Wright, J., Vrijheid, M., Andersen, A.M., Larsen, P.S., Kamper-Jorgensen, M., Adamson, A., Barros, H., Bonde, J.P., Brescianini, S., Brophy, S., Casas, M., Devereux, G., Eggesbo, M., Fantini, M.P., Frey, U., Gehring, U., Grazuleviciene, R., Henriksen, T.B., Hertz-Picciotto, I., Heude, B., Hryhorczuk, D.O., Inskip, H., Jaddoe, V.W., Lawlor, D.A., Ludvigsson, J., Kelleher, C., Kiess, W., Koletzko, B., Kuehni, C.E., Kull, I., Kyhl, H.B., Magnus, P., Momas, I., Murray, D., Pekkanen, J., Polanska, K., Porta, D., Poulsen, G., Richiardi, L., Roeleveld, N., Skovgaard, A.M., Sram, R.J., Strandberg-Larsen, K., Thijs, C., Eijsden, M. Van, Wright, J., Vrijheid, M., and Andersen, A.M.

Abstract

Item does not contain fulltext, BACKGROUND: During the past 25 years, many pregnancy and birth cohorts have been established. Each cohort provides unique opportunities for examining associations of early-life exposures with child development and health. However, to fully exploit the large amount of available resources and to facilitate cross-cohort collaboration, it is necessary to have accessible information on each cohort and its individual characteristics. The aim of this work was to provide an overview of European pregnancy and birth cohorts registered in a freely accessible database located at http://www.birthcohorts.net. METHODS: European pregnancy and birth cohorts initiated in 1980 or later with at least 300 mother-child pairs enrolled during pregnancy or at birth, and with postnatal data, were eligible for inclusion. Eligible cohorts were invited to provide information on the data and biological samples collected, as well as the timing of data collection. RESULTS: In total, 70 cohorts were identified. Of these, 56 fulfilled the inclusion criteria encompassing a total of more than 500,000 live-born European children. The cohorts represented 19 countries with the majority of cohorts located in Northern and Western Europe. Some cohorts were general with multiple aims, whilst others focused on specific health or exposure-related research questions. CONCLUSION: This work demonstrates a great potential for cross-cohort collaboration addressing important aspects of child health. The web site, http://www.birthcohorts.net, proved to be a useful tool for accessing information on European pregnancy and birth cohorts and their characteristics.

Published
2013

37. European birth cohorts for environmental health research

Author

Vrijheid, M. (Martine), Casas, M. (Maribel), Bergström, A. (Anna), Carmichael, A. (Amanda), Cordier, S. (Sylvaine), Eggesbø, M. (Merete), Eller, E. (Esben), Fantini, M.P. (Maria), Fernandez, M.F. (Mariana), Fernández-Somoano, A. (Ana), Gehring, U. (Ulrike), Grazuleviciene, R. (Regina), Hohmann, C. (C.), Karvonen, S.L., Keil, M. (Mark), Kogevinas, M. (Manolis), Koppen, G. (Gudrun), Krämer, U. (Ursula), Kuehni, C. (Claudia), Magnus, P. (Per), Majewska, R. (Renata), Nybo Andersen, A.-M. (Anne-Marie), Patelarou, E. (Evridiki), Petersen, M.S. (Maria Skaalum), Pierik, F.H. (Frank), Polanska, K. (Kinga), Porta, D. (Daniela), Richiardi, L. (Lorenzo), Santos, A.C. (Ana Cristina), Slama, R. (Rémy), Sram, R.J. (Radim), Thijs, C. (Carel), Tischer, C. (Christina), Toft, G. (Gunnar), Trnovec, T. (Tomáš), Vandentorren, S. (Stéphanie), Vrijkotte, T.G.M. (Tanja), Wilhelm, M. (Michael), Wright, J. (Juliet), Nieuwenhuijsen, M. (Mark), Vrijheid, M. (Martine), Casas, M. (Maribel), Bergström, A. (Anna), Carmichael, A. (Amanda), Cordier, S. (Sylvaine), Eggesbø, M. (Merete), Eller, E. (Esben), Fantini, M.P. (Maria), Fernandez, M.F. (Mariana), Fernández-Somoano, A. (Ana), Gehring, U. (Ulrike), Grazuleviciene, R. (Regina), Hohmann, C. (C.), Karvonen, S.L., Keil, M. (Mark), Kogevinas, M. (Manolis), Koppen, G. (Gudrun), Krämer, U. (Ursula), Kuehni, C. (Claudia), Magnus, P. (Per), Majewska, R. (Renata), Nybo Andersen, A.-M. (Anne-Marie), Patelarou, E. (Evridiki), Petersen, M.S. (Maria Skaalum), Pierik, F.H. (Frank), Polanska, K. (Kinga), Porta, D. (Daniela), Richiardi, L. (Lorenzo), Santos, A.C. (Ana Cristina), Slama, R. (Rémy), Sram, R.J. (Radim), Thijs, C. (Carel), Tischer, C. (Christina), Toft, G. (Gunnar), Trnovec, T. (Tomáš), Vandentorren, S. (Stéphanie), Vrijkotte, T.G.M. (Tanja), Wilhelm, M. (Michael), Wright, J. (Juliet), and Nieuwenhuijsen, M. (Mark)

Published
2012
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38. Development of Land Use Regression Models for PM(2.5), PM(2.5) Absorbance, PM(10) and PM(coarse) in 20 European Study Areas; Results of the ESCAPE Project.

Author

Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Eeftens, M.R., Beelen, R.M.J., de Hoogh, K., Bellander, T., Cesaroni, G., Cirach, M., Declercq, C., Dedele, A., Dons, E., de Nazelle, A., Dimakopoulou, K., Eriksen, K., Falq, G., Fischer, P., Galassi, C., Grazuleviciene, R., Heinrich, J., Hoffmann, B., Jerrett, M., Keidel, D., Korek, M., Lanki, T., Lindley, S., Madsen, C., Molter, A., Nador, G., Nieuwenhuijsen, M., Nonnemacher, M., Pedeli, X., Raaschou-Nielsen, O., Patelarou, E., Quass, U., Ranzi, A., Schindler, C., Stempfelet, M., Stephanou, E., Sugiri, D., Tsai, M.Y., Yli-Tuomi, T., Varro, M.J., Vienneau, D., von Klot, S., van der Wolf, K., Brunekreef, B., Hoek, G., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Eeftens, M.R., Beelen, R.M.J., de Hoogh, K., Bellander, T., Cesaroni, G., Cirach, M., Declercq, C., Dedele, A., Dons, E., de Nazelle, A., Dimakopoulou, K., Eriksen, K., Falq, G., Fischer, P., Galassi, C., Grazuleviciene, R., Heinrich, J., Hoffmann, B., Jerrett, M., Keidel, D., Korek, M., Lanki, T., Lindley, S., Madsen, C., Molter, A., Nador, G., Nieuwenhuijsen, M., Nonnemacher, M., Pedeli, X., Raaschou-Nielsen, O., Patelarou, E., Quass, U., Ranzi, A., Schindler, C., Stempfelet, M., Stephanou, E., Sugiri, D., Tsai, M.Y., Yli-Tuomi, T., Varro, M.J., Vienneau, D., von Klot, S., van der Wolf, K., Brunekreef, B., and Hoek, G.

Published
2012

39. European birth cohorts for environmental health research

Author

Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Vrijheid, M., Casas, M., Bergström, A., Carmichael, A., Cordier, S., Eggesbø, M., Eller, E., Fantini, M.P., Fernández, M.F., Fernández-Somoano, A., Gehring, U., Grazuleviciene, R., Hohmann, C., Karvonen, A.M., Keil, T., Kogevinas, M., Koppen, G., Krämer, U., Kuehni, C.E., Magnus, P., Majewska, R., Andersen, A., Patelarou, E., Petersen, M., Pierik, F.H., Polanska, K., Porta, D., Richiardi, L., Santos, A, Slama, R., Sram, R.J., Thijs, C., Tischer, C., Toft, G., Trnovec, T., Vandentorren, S., Vrijkotte, T.G.M., Wilhelm, M., Wright, J., Nieuwenhuijsen, M., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Vrijheid, M., Casas, M., Bergström, A., Carmichael, A., Cordier, S., Eggesbø, M., Eller, E., Fantini, M.P., Fernández, M.F., Fernández-Somoano, A., Gehring, U., Grazuleviciene, R., Hohmann, C., Karvonen, A.M., Keil, T., Kogevinas, M., Koppen, G., Krämer, U., Kuehni, C.E., Magnus, P., Majewska, R., Andersen, A., Patelarou, E., Petersen, M., Pierik, F.H., Polanska, K., Porta, D., Richiardi, L., Santos, A, Slama, R., Sram, R.J., Thijs, C., Tischer, C., Toft, G., Trnovec, T., Vandentorren, S., Vrijkotte, T.G.M., Wilhelm, M., Wright, J., and Nieuwenhuijsen, M.

Published
2012

47. Effects of Elevated Levels of Manganese and Iron in Drinking Water on Birth Outcomes.

Author

Grazuleviciene, R., Nadisauskiene, R., Buinauskiene, J., and Grazulevicius, T.

Subjects
*DRINKING water, *PHYSIOLOGICAL effects of manganese, *PHYSIOLOGICAL effects of iron, *COMPOSITION of water, *LOW birth weight
Abstract

We examined the impact of elevated exposure levels of pregnant women to manganese and iron through drinking water on pregnancy outcomes. We conducted an epidemiological study among 16,408 pregnant women of Kaunas. We assessed each woman at her residence for exposure to manganese and iron levels measured in four Kaunas public water supply networks. We used a logistic regression to model the association between drinking water quality and birth outcomes controlling the confounding variables. Analysis yielded an increase in adjusted odds ratios (AOR) for term low birth weight (LBW) for moderate exposure level, 1.53 (95% confidence interval (CI) 0.89-2.66); and 1.70 (95% CI 1.07-2.71) for high exposure level. Maternal exposure was associated with a mean reduction of 21 g (SE, 9 g; p=0.02) in birth weight. No associations were observed between manganese and iron levels and preterm birth. These findings suggest that elevated levels of manganese and iron in drinking water are associated with a reduction in birth weight in term-born infants. However, further individual-level epidemiologic studies are necessary to investigate the factors that contribute to the increased sensitivity of some pregnant women. [ABSTRACT FROM AUTHOR]

Published
2009

48. Traffic Noise Emissions and Myocardial Infarction Risk.

Author

Grazuleviciene, R., Lekaviciute, J., Mozgeris, G., Merkevicius, S., and Deikus, J.

Subjects
*TRAFFIC noise, *TRANSPORTATION noise, *MYOCARDIAL infarction, *GEOGRAPHIC information systems
Abstract

We examined the possible association between road traffic noise in residential areas and myocardial infarction (MI) incidence. We conducted an ecological study among 25-64-year-old men in the general population of Kaunas city. The study comprised all first time MI cases among stable residents of Kaunas treated in hospitals in 1999-2001 (518). We measured traffic-related noise levels at the 117 electoral districts and linked these levels to residential addresses using Geographical Information System (GIS) techniques. In daytime period (10-12 hr, 10 min.) traffic-related noise emission fluctuated between 58 dB (A) to 82 dB (A) and about 18% of citizens were exposed to noise level exceeding 65 dB (A) in their residential district. The age-adjusted MI incidence per 1,000 increased by increasing noise exposure. In the total group of 25-64 years old men the incidence tended to increase from 2.07 in the 1st (lowest) exposure area to 2.57 in the 4th (highest) exposure area (Risk ratio (RR) 1.33;95% confidence interval (CI) 0.76-2.32). In the subgroup of 55-64 years old men, the risk ratio increased by 92% (RR =1.92;95% CI 1.00-3.67). Our results indicate a relationship between traffic noise exposure and MI incidence among 55-64-year-old men. [ABSTRACT FROM AUTHOR]

Published
2004

49. Variation of NO2 and NOx concentrations between and within 36 European study areas : results from the ESCAPE study

Author

Cyrys, J., Eeftens, M., Heinrich, J., Ampe, C., Armengaud, A., Beelen, R., Bellander, T., Beregszaszai, T., Birk, M., Cesaroni, G., Cirach, M., de Hoogh, K., de Nazelle, A., de Vocht, F., Declercq, C., Dedele, A., Dimakopoulou, K., Eriksen, K., Galassi, C., Grazuleviciene, R., Grivas, G., Gruzieva, O., Hagenbjörk, Gustafsson, Hoffmann, B., Iakovides, M., Ineichen, A., Krämer, U., Lanki, T., Lozano, P., Madsen, C., Meliefste, K., Modig, L., Mölter, A., Mosler, G., Nieuwenhuijsen, M., Nonnemacher, M., Oldenwening, M., Peters, A., Pontet, S., Probst-Hensch, N., Quass, U., Raaschou-Nielsen, O., Ranzi, A., Sugiri, D., Stephanou, E. G., Taimisto, P., Tsai, M. Y., Vaskövi, E., Villani, S., Wang, M., Brunekreef, B., and Hoek, G.

Subjects
13. Climate action

50. Low level maternal smoking and infant birthweight reduction: genetic contributions of GSTT1 and GSTM1 polymorphisms

Author

Danileviciute Asta, Grazuleviciene Regina, Paulauskas Algimantas, Nadisauskiene Ruta, and Nieuwenhuijsen Mark J

Subjects
Birthweight, GST polymorphisms, Smoking, Interaction, Gynecology and obstetrics, RG1-991
Abstract

Abstract Background Genetic susceptibility to tobacco smoke might modify the effect of smoking on pregnancy outcomes. Methods We conducted a case–control study of 543 women who delivered singleton live births in Kaunas (Lithuania), examining the association between low-level tobacco smoke exposure (mean: 4.8 cigarettes/day) during pregnancy, GSTT1 and GSTM1 polymorphisms and birthweight of the infant. Multiple linear-regression analysis was performed adjusting for gestational age, maternal education, family status, body mass index, blood pressure, and parity. Subsequently, we tested for the interaction effect of maternal smoking, GSTT1 and GSTM1 genes polymorphisms with birthweight by adding all the product terms in the regression models. Results The findings suggested a birthweight reduction among light-smoking with the GSTT1–null genotype (−162.9 g, P = 0.041) and those with the GSTM1–null genotype (−118.7 g, P = 0.069). When a combination of these genotypes was considered, birthweight was significantly lower for infants of smoking women the carriers of the double-null genotypes (−311.2 g, P = 0.008). The interaction effect of maternal smoking, GSTM1 and GSTT1 genotypes was marginally significant on birthweight (−234.5 g, P = 0.078). Among non-smokers, genotype did not independently confer an adverse effect on infant birthweight. Conclusions The study shows the GSTT1–null genotype, either presents only one or both with GSTM1–null genotype in a single subject, have a modifying effect on birthweight among smoking women even though their smoking is low level. Our data also indicate that identification of the group of susceptible subjects should be based on both environmental exposure and gene polymorphism. Findings of this study add additional evidence on the interplay among two key GST genes and maternal smoking on birth weight of newborns.

Published
2012
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