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4. COVID-19 Vaccine Acceptance Among Parents of Children With Multisystem Inflammatory Syndrome in Children

Author

Blanchard-Rohner, Geraldine, Sanchez, Carlos, Andre, Maya C., Bressieux-Degueldre, Sabrina, Grazioli, Serge, Perez, Marie-Helene, Wütz, Daniela, Schöbi, Nina, Welzel, Tatjana, Atkinson, Andrew, Schlapbach, Luregn J., Bielicki, Julia A., Trück, Johannes, Koehler, Henrik, Gysi, Spyridoula, Janz, Indra, Bieri, Andreas, Donner, Birgit, Hammer, Jürg, Heininger, Ulrich, von Kalckreuth, Clemens, Kohns, Malte, Mettauer, Nicole, Meyer, Alexandra, Reppucci, Diana, Schlaeppi, Chloé, Trachsel, Daniel, Vaezipour, Nina, Woerner, Andreas, Zutter, Andreas, Vanoni, Federica, Kottanattu, Lisa, Mazzara, Calogero, Severi Conti, Alessia, Aebi, Christoph, Agyeman, Philipp, Duppenthaler, Andrea, Glöckler, Martin, Pallivathukal, Sabine, Riedel, Thomas, Zimmermann, Petra, Cudré-Cung, Hong-Phuc, Pavlovic, Mladen, Bordessoule, Alice, Martin, Anne-Laure, Polito, Angelo, Wagner, Noemie, Rohr, Marie, L’Huillier, Arnaud, Amiet, Vivianne, Ferry, Thomas, Longchamp, David, Natterer, Julia, Oppenheim, Rebecca, Hofer, Michael, Buettcher, Michael, Wechselberger, Katharina, Donas, Alex, Germann, Sara, Lütolf Erni, Michaela, Kaiser, Daniela, Schwendener Scholl, Katharina, Peter Kuen, Hans, Hrup, Katja, Stritt, Janine, Bailey, Douggl G. N., Wachinger, Tanja, Beck, Ingrid, Birkenmaier, André, Rogdo, Bjarte, Lorenz, Philip, Iglowstein, Ivo, Zöhrer, Konstanze, Flade, Martin, Prader, Seraina, Pachlopnik Schmid, Jana, Seiler, Michelle, Meyer Sauteur, Patrick, Brotschi, Barbara, Weber, Kathrin, Whittaker, Elizabeth, and Faust, Saul N.

Published
2024
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5. Cardiac assessment and inflammatory markers in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV2 (PIMS-TS) treated with methylprednisolone versus intravenous immunoglobulins: 6-month follow-up outcomes of the randomised controlled Swissped RECOVERY trial

Author

Andre, Maya C., Sanchez, Carlos, Bressieux-Degueldre, Sabrina, Perez, Marie-Helene, Wütz, Daniela, Blanchard-Rohner, Geraldine, Grazioli, Serge, Schöbi, Nina, Trück, Johannes, Welzel, Tatjana, Atkinson, Andrew, Schlapbach, Luregn J., Bielicki, Julia, Koehler, Henrik, Gysi, Spyridoula, Janz, Indra, Bieri, Andreas, Donner, Birgit, Hammer, Jürg, Heininger, Ulrich, von Kalckreuth, Clemens, Kohns, Malte, Mettauer, Nicole, Meyer, Alexandra, Reppucci, Diana, Schlaeppi, Chloé, Trachsel, Daniel, Vaezipour, Nina, Woerner, Andreas, Zutter, Andreas, Vanoni, Federica, Kottanattu, Lisa, Mazzara, Calogero, Conti, Alessia Severi, Aebi, Christoph, Agyeman, Philipp, Duppenthaler, Andrea, Glöckler, Martin, Pallivathukal, Sabine, Riedel, Thomas, Zimmermann, Petra, Cudré-Cung, Hong-Phuc, Pavlovic, Mladen, Bordessoule, Alice, Martin, Anne-Laure, Polito, Angelo, Wagner, Noemie, Rohr, Marie, L'Huillier, Arnaud, Amiet, Vivianne, Ferry, Thomas, Longchamp, David, Natterer, Julia, Oppenheim, Rebecca, Hofer, Michael, Buettcher, Michael, Wechselberger, Katharina, Donas, Alex, Germann, Sara, Erni, Michaela Lütolf, Kaiser, Daniela, Scholl, Katharina Schwendener, Kuen, Hans Peter, Hrup, Katja, Stritt, Janine, Bailey, Douggl G.N., Wachinger, Tanja, Beck, Ingrid, Birkenmaier, André, Rogdo, Bjarte, Lorenz, Philip, Iglowstein, Ivo, Zöhrer, Konstanze, Flade, Martin, Prader, Seraina, Schmid, Jana Pachlopnik, Seiler, Michelle, Sauteur, Patrick Meyer, Brotschi, Barbara, Weber, Kathrin, Whittaker, Elizabeth, and Faust, Saul N.

Published
2024
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8. Machine learning using the extreme gradient boosting (XGBoost) algorithm predicts 5-day delta of SOFA score at ICU admission in COVID-19 patients

Author

Alfaro-Farias, Mario, Vizmanos-Lamotte, Gerardo, Tschoellitsch, Thomas, Meier, Jens, Aguirre-Bermeo, Hernán, Apolo, Janina, Martínez, Alberto, Jurkolow, Geoffrey, Delahaye, Gauthier, Novy, Emmanuel, Losser, Marie-Reine, Wengenmayer, Tobias, Rilinger, Jonathan, Staudacher, Dawid L., David, Sascha, Welte, Tobias, Stahl, Klaus, Pavlos”, “Agios, Aslanidis, Theodoros, Korsos, Anita, Babik, Barna, Nikandish, Reza, Rezoagli, Emanuele, Giacomini, Matteo, Nova, Alice, Fogagnolo, Alberto, Spadaro, Savino, Ceriani, Roberto, Murrone, Martina, Wu, Maddalena A., Cogliati, Chiara, Colombo, Riccardo, Catena, Emanuele, Turrini, Fabrizio, Simonini, Maria Sole, Fabbri, Silvia, Potalivo, Antonella, Facondini, Francesca, Gangitano, Gianfilippo, Perin, Tiziana, Grazia Bocci, Maria, Antonelli, Massimo, Gommers, Diederik, Rodríguez-García, Raquel, Gámez-Zapata, Jorge, Taboada-Fraga, Xiana, Castro, Pedro, Tellez, Adrian, Lander-Azcona, Arantxa, Escós-Orta, Jesús, Martín-Delgado, Maria C., Algaba-Calderon, Angela, Franch-Llasat, Diego, Roche-Campo, Ferran, Lozano-Gómez, Herminia, Zalba-Etayo, Begoña, Michot, Marc P., Klarer, Alexander, Ensner, Rolf, Schott, Peter, Urech, Severin, Zellweger, Nuria, Merki, Lukas, Lambert, Adriana, Laube, Marcus, Jeitziner, Marie M., Jenni-Moser, Beatrice, Wiegand, Jan, Yuen, Bernd, Lienhardt-Nobbe, Barbara, Westphalen, Andrea, Salomon, Petra, Drvaric, Iris, Hillgaertner, Frank, Sieber, Marianne, Dullenkopf, Alexander, Petersen, Lina, Chau, Ivan, Ksouri, Hatem, Sridharan, Govind Oliver, Cereghetti, Sara, Boroli, Filippo, Pugin, Jerome, Grazioli, Serge, Rimensberger, Peter C., Bürkle, Christian, Marrel, Julien, Brenni, Mirko, Fleisch, Isabelle, Lavanchy, Jerome, Perez, Marie-Helene, Ramelet, Anne-Sylvie, Weber, Anja Baltussen, Gerecke, Peter, Christ, Andreas, Ceruti, Samuele, Glotta, Andrea, Marquardt, Katharina, Shaikh, Karim, Hübner, Tobias, Neff, Thomas, Redecker, Hermann, Moret-Bochatay, Mallory, Bentrup, FriederikeMeyer zu, Studhalter, Michael, Stephan, Michael, Brem, Jan, Gehring, Nadine, Selz, Daniela, Naon, Didier, Kleger, Gian-Reto, Pietsch, Urs, Filipovic, Miodrag, Ristic, Anette, Sepulcri, Michael, Heise, Antje, Franchitti Laurent, Marilene, Laurent, Jean-Christophe, Wendel Garcia, Pedro D., Schuepbach, Reto, Heuberger, Dorothea, Bühler, Philipp, Brugger, Silvio, Fodor, Patricia, Locher, Pascal, Camen, Giovanni, Gaspert, Tomislav, Jovic, Marija, Haberthuer, Christoph, Lussman, Roger F., Colak, Elif, Montomoli, Jonathan, Romeo, Luca, Moccia, Sara, Bernardini, Michele, Migliorelli, Lucia, Berardini, Daniele, Donati, Abele, Carsetti, Andrea, Bocci, Maria Grazia, Wendel Garcia, Pedro David, Fumeaux, Thierry, Guerci, Philippe, Schüpbach, Reto Andreas, Ince, Can, Frontoni, Emanuele, and Hilty, Matthias Peter

Published
2021
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9. COVID-19 Vaccine Acceptance Among Parents of Children With Multisystem Inflammatory Syndrome in Children

Author

Blanchard-Rohner, Geraldine; https://orcid.org/0000-0002-9974-2172, Sanchez, Carlos, Andre, Maya C, Bressieux-Degueldre, Sabrina, Grazioli, Serge, Perez, Marie-Helene, Wütz, Daniela; https://orcid.org/0000-0002-5186-2634, Schöbi, Nina, Welzel, Tatjana, Atkinson, Andrew, Schlapbach, Luregn J; https://orcid.org/0000-0003-2281-2598, Bielicki, Julia A, Trück, Johannes; https://orcid.org/0000-0002-0418-7381, Swissped RECOVERY Trial Group, et al, Prader, Seraina; https://orcid.org/0000-0002-2950-5411, Pachlopnik Schmid, Jana; https://orcid.org/0000-0002-6653-9047, Seiler, Michelle; https://orcid.org/0000-0002-1263-5818, Meyer Sauteur, Patrick, Brotschi, Barbara; https://orcid.org/0000-0002-4472-5199, Weber, Kathrin, Blanchard-Rohner, Geraldine; https://orcid.org/0000-0002-9974-2172, Sanchez, Carlos, Andre, Maya C, Bressieux-Degueldre, Sabrina, Grazioli, Serge, Perez, Marie-Helene, Wütz, Daniela; https://orcid.org/0000-0002-5186-2634, Schöbi, Nina, Welzel, Tatjana, Atkinson, Andrew, Schlapbach, Luregn J; https://orcid.org/0000-0003-2281-2598, Bielicki, Julia A, Trück, Johannes; https://orcid.org/0000-0002-0418-7381, Swissped RECOVERY Trial Group, et al, Prader, Seraina; https://orcid.org/0000-0002-2950-5411, Pachlopnik Schmid, Jana; https://orcid.org/0000-0002-6653-9047, Seiler, Michelle; https://orcid.org/0000-0002-1263-5818, Meyer Sauteur, Patrick, Brotschi, Barbara; https://orcid.org/0000-0002-4472-5199, and Weber, Kathrin

Abstract

Data on COVID-19 vaccine acceptability among parents of children with multisystem inflammatory syndrome (MIS-C) are limited. In this cohort of children with MIS-C, enrolled in the Swissped RECOVERY trial (NCT04826588), comparing intravenous immunoglobulins or methylprednisolone, who, in accordance with Swiss guidelines, were recommended for SARS-CoV-2 vaccination, 65% (73/112) of parents reported being vaccinated against SARS-CoV-2 before the MIS-C, while 70% were vaccinated after the MIS-C episode of their child. None of the children were vaccinated before the occurrence of the MIS-C, and only 9% (5/56) received the COVID-19 vaccine after the MIS-C. The predominant barriers to COVID-19 vaccination were concerns over potential side effects and insufficient support from their doctors. This emphasizes the crucial role of health care providers in promoting COVID-19 vaccination among children.

Published
2024

10. Cardiac assessment and inflammatory markers in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV2 (PIMS-TS) treated with methylprednisolone versus intravenous immunoglobulins: 6-month follow-up outcomes of the randomised controlled Swissped RECOVERY trial

Author

Maya C, Andre; https://orcid.org/0000-0003-1555-2011, Sanchez, Carlos; https://orcid.org/0000-0002-1572-7590, Bressieux-Degueldre, Sabrina, Perez, Marie-Hélène, Wütz, Daniela; https://orcid.org/0000-0002-5186-2634, Blanchard-Rohner, Geraldine; https://orcid.org/0000-0002-9974-2172, Grazioli, Serge; https://orcid.org/0000-0002-5526-851X, Schöbi, Nina, Trück, Johannes; https://orcid.org/0000-0002-0418-7381, Welzel, Tatjana, Atkinson, Andrew; https://orcid.org/0000-0001-5834-8315, Schlapbach, Luregn J, Bielicki, Julia, Swissped RECOVERY Trial Group, Maya C, Andre; https://orcid.org/0000-0003-1555-2011, Sanchez, Carlos; https://orcid.org/0000-0002-1572-7590, Bressieux-Degueldre, Sabrina, Perez, Marie-Hélène, Wütz, Daniela; https://orcid.org/0000-0002-5186-2634, Blanchard-Rohner, Geraldine; https://orcid.org/0000-0002-9974-2172, Grazioli, Serge; https://orcid.org/0000-0002-5526-851X, Schöbi, Nina, Trück, Johannes; https://orcid.org/0000-0002-0418-7381, Welzel, Tatjana, Atkinson, Andrew; https://orcid.org/0000-0001-5834-8315, Schlapbach, Luregn J, Bielicki, Julia, and Swissped RECOVERY Trial Group

Abstract

Background: Previous findings from the Swissped RECOVERY trial showed that patients with Pediatric Inflammatory Multisystem Syndrome-Temporally Associated with SARS-CoV-2 (PIMS-TS) who were randomly assigned to intravenous immunoglobulins or methylprednisolone have a comparable length of hospital stay. Here, we report the 6-month follow-up outcomes of cardiac pathologies and normalisation of clinical or laboratory signs of inflammation from this study population. Methods: This pre-planned follow-up of patients with PIMS-TS included the Swissped RECOVERY Trial reports on the 6-month outcomes of the cohort after randomisation, with a focus on cardiac, haematological, and biochemical findings. The trial was an investigator-initiated randomised multicentre open-label two-arm trial in children and adolescents hospitalised with PIMS-TS at ten hospitals in Switzerland. Cardiological assessments and laboratory analyses were prospectively collected in the intention-to-treat analysis on pre-defined intervals after hospital discharge. Differences between randomised arms were investigated using Chi-square test for categorical and Wilcoxon test for continuous variables. The trial is registered with the Swiss National Clinical Trials Portal (SNCTP000004720) and ClinicalTrials.gov (NCT04826588). Findings: Between May 21, 2021 and April 15, 2022, 75 patients with a median age of 9.1 years (IQR 6.2-12.2) were included in the intention-to-treat population (37 in the methylprednisolone group and 38 in the intravenous immunoglobulin group). During follow-up, the incidence of abnormal left ventricular systolic function, coronary artery aneurysms (CAA), and other signs of inflammation were comparable in both groups. However, we detected cardiac abnormalities with low incidence and a mild degree grade of pathology. CAAs were observed in 2/38 children (5.3%) in the IVIG group and 1/37 children (2.7%) in the methylprednisolone group at 6-month follow-up (difference proportion 0.75; 95% conf

Published
2024

11. Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort

Author

Alfaro Farias, Mario, Margarit, Antoni, Vizmanos-Lamotte, Gerardo, Tschoellitsch, Thomas, Meier, Jens, Cardona, Francesco S., Skola, Josef, Horakova, Lenka, Aguirre-Bermeo, Hernan, Apolo, Janina, Novy, Emmanuel, Losser, Marie-Reine, Jurkolow, Geoffrey, Delahaye, Gauthier, David, Sascha, Welte, Tobias, Wengenmayer, Tobias, Staudacher, Dawid L., Aslanidis, Theodoros, Babik, Barna, Korsos, Anita, Gal, Janos, Csaba, Hermann, Donati, Abele, Carsetti, Andrea, Turrini, Fabrizio, Simonini, Maria Sole, Ceriani, Roberto, Murrone, Martina, Rezoagli, Emanuele, Vitale, Giovanni, Fogagnolo, Alberto, Spadaro, Savino, Wu, Maddalena Alessandra, Cogliati, Chiara, Colombo, Riccardo, Catena, Emanuele, Facondini, Francesca, Potalivo, Antonella, Gangitano, Gianfilippo, Perin, Tiziana, Bocci, Maria Grazia, Antonelli, Massimo, Gommers, Diederik, Ince, Can, Mayor-Vázquez, Eric, Cruz, Maria, Delgado, Martin, Garcia, Raquel Rodriguez, Gamez Zapata, Jorge, Zalba-Etayo, Begoña, Lozano-Gomez, Herminia, Castro, Pedro, Tellez, Adrian, Jacas, Adriana, Muñoz, Guido, Andrea, Rut, Ortiz, Jose, Quintana, Eduard, Rovira, Irene, Reverter, Enric, Fernandez, Javier, Ferrer, Miquel, Badia, Joan R., Lander Azcona, Arantxa, Orta, Jesus Escos, Bühler, Philipp, Brugger, Silvio, Hofmaenner, Daniel, Unseld, Simone, Ruschitzka, Frank, Moret-Bochatay, Mallory, Yuen, Bernd, Hillermann, Thomas, Ksouri, Hatem, Sridharan, Govind Oliver, Ristic, Anette, Sepulcri, Michael, Filipovic, Miodrag, Pietsch, Urs, Salomon, Petra, Drvaric, Iris, Schott, Peter, Urech, Severin, Lambert, Adriana, Merki, Lukas, Laube, Marcus, Hillgaertner, Frank, Sieber, Marianne, Dullenkopf, Alexander, Petersen, Lina, Grazioli, Serge, Rimensberger, Peter C., Fleisch, Isabelle, Lavanchy, Jerome, Marquardt, Katharina, Shaikh, Karim, Redecker, Hermann, Stephan, Michael, Brem, Jan, Rogdo, Bjarte, Birkenmaier, Andre, Meyer zu Bentrup, Friederike, Fodor, Patricia, Locher, Pascal, Camen, Giovanni, Siegemund, Martin, Zellweger, Nuria, Jeitziner, Marie-Madlen, Jenni-Moser, Beatrice, Bürkle, Christian, Kleger, Gian-Reto, Franchitti Laurent, Marilene, Laurent, Jean-Christophe, Gaspert, Tomislav, Jovic, Marija, Studhalter, Michael, Haberthuer, Christoph, Lussman, Roger F., Selz, Daniela, Naon, Didier, Mauri, Romano, Ceruti, Samuele, Marrel, Julien, Brenni, Mirko, Ensner, Rolf, Gehring, Nadine, Heise, Antje, Huebner, Tobias, Neff, Thomas A., Cereghetti, Sara, Boroli, Filippo, Pugin, Jerome, Marczin, Nandor, Wong, Joyce, Wendel Garcia, Pedro David, Fumeaux, Thierry, Guerci, Philippe, Heuberger, Dorothea Monika, Montomoli, Jonathan, Roche-Campo, Ferran, Schuepbach, Reto Andreas, and Hilty, Matthias Peter

Published
2020
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14. Methylprednisolone versus intravenous immunoglobulins in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): an open-label, multicentre, randomised trial

Author

Welzel, Tatjana, primary, Atkinson, Andrew, additional, Schöbi, Nina, additional, Andre, Maya C, additional, Bailey, Douggl G N, additional, Blanchard-Rohner, Geraldine, additional, Buettcher, Michael, additional, Grazioli, Serge, additional, Koehler, Henrik, additional, Perez, Marie-Helene, additional, Trück, Johannes, additional, Vanoni, Federica, additional, Zimmermann, Petra, additional, Sanchez, Carlos, additional, Bielicki, Julia A, additional, Schlapbach, Luregn J, additional, Bieri, Andreas, additional, Gysi, Spyridoula, additional, Janz, Indra, additional, Donner, Birgit, additional, Hammer, Jürg, additional, Heininger, Ulrich, additional, Kohns Vasconcelos, Malte, additional, Mettauer, Nicole, additional, Meyer, Alexandra, additional, Reppucci, Diana, additional, Schlaeppi, Chloé, additional, Trachsel, Daniel, additional, Vaezipour, Nina, additional, von Kalckreuth, Clemens, additional, Woerner, Andreas, additional, Zutter, Andreas, additional, Kottanattu, Lisa, additional, Mazzara, Calogero, additional, Severi Conti, Alessia, additional, Aebi, Christoph, additional, Agyeman, Philipp K A, additional, Duppenthaler, Andrea, additional, Glöckler, Martin, additional, Pallivathukal, Sabine, additional, Riedel, Thomas, additional, Cudré-Cung, Hong-Phuc, additional, Pavlovic, Mladen, additional, Bordessoule, Alice, additional, L'Huillier, Arnaud G, additional, Martin, Anne-Laure, additional, Polito, Angelo, additional, Rohr, Marie, additional, Rodriguez, Maria Isabel, additional, Wagner, Noemie, additional, Chanez, Vivianne, additional, Bressieux-Degueldre, Sabrina, additional, Ferry, Thomas, additional, Hofer, Michael, additional, Longchamp, David, additional, Natterer, Julia, additional, Oppenheim, Rebecca, additional, Donas, Alex, additional, Germann, Sara, additional, Hrup, Katja, additional, Kaiser, Daniela, additional, Kuen, Hans Peter, additional, Lütolf Erni, Michaela, additional, Schwendener Scholl, Katharina, additional, Stritt, Janine, additional, Wechselberger, Katharina, additional, Beck, Ingrid, additional, Birkenmaier, André, additional, Flade, Martin, additional, Rogdo, Bjarte, additional, Iglowstein, Ivo, additional, Lorenz, Philip, additional, Wachinger, Tanja, additional, Zöhrer, Konstanze, additional, Brotschi, Barbara, additional, Meyer Sauteur, Patrick M, additional, Pachlopnik Schmid, Jana, additional, Prader, Seraina, additional, Seiler, Michelle, additional, Weber, Kathrin, additional, Wütz, Daniela, additional, Whittaker, Elizabeth, additional, and Faust, Saul N, additional

Published
2023
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15. Antibody response in children with multisystem inflammatory syndrome related to COVID-19 (MIS-C) compared to children with uncomplicated COVID-19

Author

Thiriard, Anaïs, primary, Meyer, Benjamin, additional, Eberhardt, Christiane S., additional, Loevy, Natasha, additional, Grazioli, Serge, additional, Adouan, Wafae, additional, Fontannaz, Paola, additional, Marechal, Fabienne, additional, L’Huillier, Arnaud G., additional, Siegrist, Claire-Anne, additional, Georges, Daphnée, additional, Putignano, Antonella, additional, Marchant, Arnaud, additional, Didierlaurent, Arnaud M., additional, and Blanchard-Rohner, Geraldine, additional

Published
2023
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16. Antibody response in children with multisystem inflammatory syndrome related to COVID-19 (MIS-C) compared to children with uncomplicated COVID-19.

Author

Thiriard, Anaïs, Meyer, Benjamin, Eberhardt, Christiane Sigrid, Loevy, Natasha, Grazioli, Serge, Adouan, Wafae, Fontannaz, Paola, Marechal, Fabienne, L'Huillier, Arnaud G, Siegrist, Claire-Anne, Georges, Daphnée, Putignano, Antonella, Marchant, Arnaud, Didierlaurent, Arnaud M, Blanchard-Rohner, Geraldine, Thiriard, Anaïs, Meyer, Benjamin, Eberhardt, Christiane Sigrid, Loevy, Natasha, Grazioli, Serge, Adouan, Wafae, Fontannaz, Paola, Marechal, Fabienne, L'Huillier, Arnaud G, Siegrist, Claire-Anne, Georges, Daphnée, Putignano, Antonella, Marchant, Arnaud, Didierlaurent, Arnaud M, and Blanchard-Rohner, Geraldine

Abstract

To comprehensively analyze the quality of the antibody response between children with Multisystem inflammatory syndrome (MIS-C) and age-matched controls at one month after SARS-CoV-2 exposure, and infected in the same time-period., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

17. Methylprednisolone versus intravenous immunoglobulins in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): an open-label, multicentre, randomised trial

Author

Welzel, Tatjana, Atkinson, Andrew, Schöbi, Nina, Andre, Maya C, Bailey, Douggl G N, Blanchard-Rohner, Geraldine, Buettcher, Michael, Grazioli, Serge, Koehler, Henrik, Perez, Marie-Helene, Trück, Johannes, Vanoni, Federica, Zimmermann, Petra, Sanchez, Carlos, Bielicki, Julia A, Schlapbach, Luregn J, and University of Zurich

Subjects
Coronavirus, Zurich, MISC, 10036 Medical Clinic, own, 610 Medicine & health, 610 Medizin und Gesundheit, RCT, COVID, PIMS
Abstract

BACKGROUND The emergence of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) led to the widespread use of anti-inflammatory treatments in the absence of evidence from randomised controlled trials (RCTs). We aimed to assess the effectiveness of intravenous methylprednisolone compared with intravenous immunoglobulins. METHODS This is an open-label, multicentre, two-arm RCT done at ten hospitals in Switzerland in children younger than 18 years hospitalised with PIMS-TS (defined as age

Published
2023
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20. Multicenter Randomized Trial of Methylprednisolone vs. Intravenous Immunoglobulins to Treat the Pediatric Inflammatory Multisystem Syndrome—Temporally Associated With SARS-CoV-2 (PIMS-TS): Protocol of the Swissped RECOVERY Trial

Author

Welzel, Tatjana, Schöbi, Nina, André, Maya C., Bailey, Douggl G. N., Blanchard-Rohner, Geraldine, Buettcher, Michael, Grazioli, Serge, Koehler, Henrik, Perez, Marie-Helene, Trück, Johannes, Vanoni, Federica, Zimmermann, Petra, Atkinson, Andrew, Sanchez, Carlos, Whittaker, Elizabeth, Faust, Saul N., Bielicki, Julia A., and Schlapbach, Luregn J.

Subjects
hemic and lymphatic diseases, Pediatrics, Perinatology and Child Health, 610 Medicine & health
Abstract

IntroductionIn 2020, a new disease entitled Pediatric Inflammatory Multisystem Syndrome temporally associated with COVID-19 (PIMS-TS), or Multisystem Inflammatory Syndrome in Children (MIS-C), emerged, with thousands of children affected globally. There is no available evidence based on randomized controlled trials (RCT) to date on the two most commonly used immunomodulatory treatments, intravenous immunoglobulins (IVIG) and corticosteroids. Therefore, the Swissped RECOVERY trial was conducted to assess whether intravenous (IV) methylprednisolone shortens hospital length of stay compared with IVIG.Methods and AnalysisSwissped RECOVERY is an ongoing investigator-initiated, open-label, multicenter two-arm RCT in children and adolescents SignificanceCurrently, robust trial evidence for the treatment of PIMS-TS is lacking, with a controversy surrounding the use of corticosteroids vs. IVIG. This trial will provide evidence for the effectiveness and safety of these two treatments.Ethics and DisseminationThe study protocol, which was designed based on the U.K. RECOVERY trial, the patient information and consent forms, and other study-specific study documents were approved by the local ethics committees (Project ID: 2021-00362).Registration DetailsThe study is registered on the Swiss National Clinical Trials Portal (SNCTP000004720) and Clinicaltrials.gov (NCT 04826588).

Published
2022
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21. The SARS-CoV-2 Pandemic Impacts the Management of Swiss Pediatric Intensive Care Units

Author

Soomann, Maarja, Wendel-Garcia, Pedro D, Kaufmann, Mark, Grazioli, Serge, Perez, Marie-Helene, Hilty, Matthias P, André, Maya C, Brotschi, Barbara, Soomann, Maarja, Wendel-Garcia, Pedro D, Kaufmann, Mark, Grazioli, Serge, Perez, Marie-Helene, Hilty, Matthias P, André, Maya C, and Brotschi, Barbara

Abstract

The impact of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic on pediatric intensive care units (PICUs) is difficult to quantify. We conducted an observational study in all eight Swiss PICUs between 02/24/2020 and 06/15/2020 to characterize the logistical and medical aspects of the pandemic and their impact on the management of the Swiss PICUs. The nine patients admitted to Swiss PICUs during the study period suffering from pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) and constituting 14% (9/63) of all SARS-CoV-2 positive hospitalized patients in Swiss children's hospitals caused a higher workload [total Nine Equivalents of nursing Manpower use Score (NEMS) points, p = 0.0008] and were classified to higher workload categories (p < 0.0001) than regular PICU patients (n = 4,881) admitted in 2019. The comparison of the characteristics of the eight Swiss PICUs shows that they were confronted by different organizational issues arising from temporary regulations put in place by the federal council. These general regulations had different consequences for the eight individual PICUs due to the differences between the PICUs. In addition, the temporal relationship of these different regulations influenced the available PICU resources, dependent on the characteristics of the individual PICUs. As pandemic continues, reflecting and learning from experience is essential to reduce workload, optimize bed occupancy and manage resources in each individual PICU. In a small country as Switzerland, with a relatively decentralized health care local differences between PICUs are considerable and should be taken into account when making policy decisions.

Published
2022

24. Immunological assessment of pediatric multisystem inflammatory syndrome related to COVID-19

Author

Grazioli, Serge, Tavaglione, Fedora, Torriani, Giulia, Wagner, Noemie, Rohr, Marie, L’Huillier, Arnaud G, Leclercq, Charlotte, Perrin, Anne, Bordessoule, Alice, Beghetti, Maurice, Pachlopnik Schmid, Jana, Vavassori, Stefano, Perreau, Matthieu, Eberhardt, Christiane, Didierlaurent, Arnaud, Kaiser, Laurent, Eckerle, Isabella, Roux-Lombard, Pascale, Blanchard-Rohner, Geraldine, University of Zurich, and Blanchard-Rohner, Geraldine

Subjects
ddc:616, ddc:618, SARS-CoV-2, COVID-19, 610 Medicine & health, 2700 General Medicine, General Medicine, Antibodies, Neutralizing, Pediatrics, Perinatology, Systemic Inflammatory Response Syndrome, immunological and virological workup, and Child Health, AcademicSubjects/MED00290, Infectious Diseases, 10036 Medical Clinic, Humans, Original Article, AcademicSubjects/MED00670, Child, multisystem inflammatory syndrome in children
Abstract

Recently, cases of multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19) have been reported worldwide. Negative polymerase chain reaction (RT-PCR) testing associated with positive serology in most of the cases suggests a postinfectious syndrome. Because the pathophysiology of this syndrome is still poorly understood, extensive virological and immunological investigations are needed.We report a series of 4 pediatric patients admitted to Geneva University Hospitals with persistent fever and laboratory evidence of inflammation meeting the published definition of MIS-C related to COVID-19, to whom an extensive virological and immunological workup was performed.RT-PCRs on multiple anatomical compartments were negative, whereas anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin A (IgA) and immunoglobulin G (IgG) were strongly positive by enzyme-linked immunosorbent assay and immunofluorescence. Both pseudoneutralization and full virus neutralization assays showed the presence of neutralizing antibodies in all children, confirming a recent infection with SARS-CoV-2. The analyses of cytokine profiles revealed an elevation in all cytokines, as reported in adults with severe COVID-19. Although differing in clinical presentation, some features of MIS-C show phenotypic overlap with hemophagocytic lymphohistiocytosis (HLH). In contrast to patients with primary HLH, our patients showed normal perforin expression and natural killer (NK) cell degranulation. The levels of soluble interleukin (IL)-2 receptor (sIL-2R) correlated with the severity of disease, reflecting recent T-cell activation.Our findings suggest that MIS-C related to COVID-19 is caused by a postinfectious inflammatory syndrome associated with an elevation in all cytokines, and markers of recent T-cell activation (sIL-2R) occurring despite a strong and specific humoral response to SARS-CoV-2. Further functional and genetic analyses are essential to better understand the mechanisms of host-pathogen interactions.

Published
2021

25. Machine learning using the extreme gradient boosting (XGBoost) algorithm predicts 5-day delta of SOFA score at ICU admission in COVID-19 patients

Author

Montomoli, Jonathan, primary, Romeo, Luca, additional, Moccia, Sara, additional, Bernardini, Michele, additional, Migliorelli, Lucia, additional, Berardini, Daniele, additional, Donati, Abele, additional, Carsetti, Andrea, additional, Bocci, Maria Grazia, additional, Wendel Garcia, Pedro David, additional, Fumeaux, Thierry, additional, Guerci, Philippe, additional, Schüpbach, Reto Andreas, additional, Ince, Can, additional, Frontoni, Emanuele, additional, Hilty, Matthias Peter, additional, Alfaro-Farias, Mario, additional, Vizmanos-Lamotte, Gerardo, additional, Tschoellitsch, Thomas, additional, Meier, Jens, additional, Aguirre-Bermeo, Hernán, additional, Apolo, Janina, additional, Martínez, Alberto, additional, Jurkolow, Geoffrey, additional, Delahaye, Gauthier, additional, Novy, Emmanuel, additional, Losser, Marie-Reine, additional, Wengenmayer, Tobias, additional, Rilinger, Jonathan, additional, Staudacher, Dawid L., additional, David, Sascha, additional, Welte, Tobias, additional, Stahl, Klaus, additional, Pavlos”, “Agios, additional, Aslanidis, Theodoros, additional, Korsos, Anita, additional, Babik, Barna, additional, Nikandish, Reza, additional, Rezoagli, Emanuele, additional, Giacomini, Matteo, additional, Nova, Alice, additional, Fogagnolo, Alberto, additional, Spadaro, Savino, additional, Ceriani, Roberto, additional, Murrone, Martina, additional, Wu, Maddalena A., additional, Cogliati, Chiara, additional, Colombo, Riccardo, additional, Catena, Emanuele, additional, Turrini, Fabrizio, additional, Simonini, Maria Sole, additional, Fabbri, Silvia, additional, Potalivo, Antonella, additional, Facondini, Francesca, additional, Gangitano, Gianfilippo, additional, Perin, Tiziana, additional, Grazia Bocci, Maria, additional, Antonelli, Massimo, additional, Gommers, Diederik, additional, Rodríguez-García, Raquel, additional, Gámez-Zapata, Jorge, additional, Taboada-Fraga, Xiana, additional, Castro, Pedro, additional, Tellez, Adrian, additional, Lander-Azcona, Arantxa, additional, Escós-Orta, Jesús, additional, Martín-Delgado, Maria C., additional, Algaba-Calderon, Angela, additional, Franch-Llasat, Diego, additional, Roche-Campo, Ferran, additional, Lozano-Gómez, Herminia, additional, Zalba-Etayo, Begoña, additional, Michot, Marc P., additional, Klarer, Alexander, additional, Ensner, Rolf, additional, Schott, Peter, additional, Urech, Severin, additional, Zellweger, Nuria, additional, Merki, Lukas, additional, Lambert, Adriana, additional, Laube, Marcus, additional, Jeitziner, Marie M., additional, Jenni-Moser, Beatrice, additional, Wiegand, Jan, additional, Yuen, Bernd, additional, Lienhardt-Nobbe, Barbara, additional, Westphalen, Andrea, additional, Salomon, Petra, additional, Drvaric, Iris, additional, Hillgaertner, Frank, additional, Sieber, Marianne, additional, Dullenkopf, Alexander, additional, Petersen, Lina, additional, Chau, Ivan, additional, Ksouri, Hatem, additional, Sridharan, Govind Oliver, additional, Cereghetti, Sara, additional, Boroli, Filippo, additional, Pugin, Jerome, additional, Grazioli, Serge, additional, Rimensberger, Peter C., additional, Bürkle, Christian, additional, Marrel, Julien, additional, Brenni, Mirko, additional, Fleisch, Isabelle, additional, Lavanchy, Jerome, additional, Perez, Marie-Helene, additional, Ramelet, Anne-Sylvie, additional, Weber, Anja Baltussen, additional, Gerecke, Peter, additional, Christ, Andreas, additional, Ceruti, Samuele, additional, Glotta, Andrea, additional, Marquardt, Katharina, additional, Shaikh, Karim, additional, Hübner, Tobias, additional, Neff, Thomas, additional, Redecker, Hermann, additional, Moret-Bochatay, Mallory, additional, Bentrup, FriederikeMeyer zu, additional, Studhalter, Michael, additional, Stephan, Michael, additional, Brem, Jan, additional, Gehring, Nadine, additional, Selz, Daniela, additional, Naon, Didier, additional, Kleger, Gian-Reto, additional, Pietsch, Urs, additional, Filipovic, Miodrag, additional, Ristic, Anette, additional, Sepulcri, Michael, additional, Heise, Antje, additional, Franchitti Laurent, Marilene, additional, Laurent, Jean-Christophe, additional, Wendel Garcia, Pedro D., additional, Schuepbach, Reto, additional, Heuberger, Dorothea, additional, Bühler, Philipp, additional, Brugger, Silvio, additional, Fodor, Patricia, additional, Locher, Pascal, additional, Camen, Giovanni, additional, Gaspert, Tomislav, additional, Jovic, Marija, additional, Haberthuer, Christoph, additional, Lussman, Roger F., additional, and Colak, Elif, additional

Published
2021
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26. X-Linked Lymphoproliferative Disease Mimicking Multisystem Inflammatory Syndrome in Children—A Case Report

Author

Prader, Seraina, primary, Ritz, Nicole, additional, Baleydier, Frédéric, additional, Andre, Maya C., additional, Stähli, Noémie, additional, Schmid, Kevin, additional, Schmid, Hanna, additional, Woerner, Andreas, additional, Diesch, Tamara, additional, Meyer Sauteur, Patrick M., additional, Trück, Johannes, additional, Gebistorf, Fabienne, additional, Opitz, Lennart, additional, Killian, Michael P., additional, Marchetti, Tommaso, additional, Vavassori, Stefano, additional, Blanchard-Rohner, Géraldine, additional, Mc Lin, Valerie, additional, Grazioli, Serge, additional, and Pachlopnik Schmid, Jana, additional

Published
2021
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27. Additional file 1 of Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort

Author

Garcia, Pedro D. Wendel, Aguirre-Bermeo, Hernán, Buehler, Philipp K., Alfaro-Farias, Mario, Yuen, Bernd, David, Sascha, Tschoellitsch, Thomas, Wengenmayer, Tobias, Korsos, Anita, Fogagnolo, Alberto, Gian-Reto Kleger, Wu, Maddalena A., Colombo, Riccardo, Turrini, Fabrizio, Potalivo, Antonella, Rezoagli, Emanuele, Rodríguez-García, Raquel, Castro, Pedro, Lander-Azcona, Arantxa, Martín-Delgado, Maria C., Lozano-Gómez, Herminia, Ensner, Rolf, Michot, Marc P., Gehring, Nadine, Schott, Peter, Siegemund, Martin, Merki, Lukas, Wiegand, Jan, Jeitziner, Marie M., Laube, Marcus, Salomon, Petra, Hillgaertner, Frank, Dullenkopf, Alexander, Ksouri, Hatem, Cereghetti, Sara, Grazioli, Serge, Bürkle, Christian, Marrel, Julien, Fleisch, Isabelle, Marie-Helene Perez, Weber, Anja Baltussen, Ceruti, Samuele, Marquardt, Katharina, Hübner, Tobias, Redecker, Hermann, Studhalter, Michael, Stephan, Michael, Selz, Daniela, Pietsch, Urs, Ristic, Anette, Heise, Antje, Bentrup, Friederike Meyer Zu, Laurent, Marilene Franchitti, Fodor, Patricia, Gaspert, Tomislav, Haberthuer, Christoph, Colak, Elif, Heuberger, Dorothea M., Fumeaux, Thierry, Montomoli, Jonathan, Guerci, Philippe, Schuepbach, Reto A., Hilty, Matthias P., and Roche-Campo, Ferran

Abstract

Additional file 1. e-Appendix 1: Specifications on the RISC-19-ICU registry structure and data collection. e-Appendix 2: Missing data handling. e-Table 1: Overall “unmatched” baseline characteristics on Day 0. e-Figure 1: “Love Plot” presenting Standardized Mean Differences between the unmatched and matchedcohort. e-Table 2: Demographics, characteristics at ICU admission, progression of respiratory support and outcome; stratified by survivor status. e-Table 3: Progression of respiratory support stratified by respiratory support strategy at ICU admission. e-Figure 2: Temporal relationship between the period of admission to the intensive care unit and the use of respiratory support strategies or mortality rate. e-Figure 3: Kaplan Meier curves for intensive care unit mortality stratified by the period of admission to the intensive care unit. e-Table 4: Demographics, characteristics at ICU admission, progression of respiratory support and outcome for patients never requiring intubation and invasive mechanical ventilation. e-Figure 4: C-Reactive Protein stratified by respiratory support strategy on Day 0 over the first week of ICU stay. e-Table 5: Mixed Effect Model of C-Reactive Protein stratified by respiratory support strategy on Day 0 over the first week of ICU stay. e-Figure 5: Multivariable adjusted COX regression model for the incidence of intubation. e-Figure 6: Multivariable adjusted COX regression model for overall ICU mortality. e-Figure 7: Multivariable adjusted COX regression model for ICU mortality (intubated patients only). e-Figure 8: Multivariable adjusted COX regression model for ICU discharge (intubated patients only). e-Table 6: Prognostic Model for the identification of patients with lower ICU mortality risk after a failed HFNC or NIV trial. e-Figure 9: Nomogram, Receiver Operating Curves and stratified Kaplan Meier curve for a prognostic model identifying patients with lower ICU mortality risk after a failed HFNC or NIV trial. e-Table 7: Area Under the Receiver Operating Curves (AUROCs) for the Prognostic Score versus classic severity scores.

Published
2021
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28. X-Linked Lymphoproliferative Disease Mimicking Multisystem Inflammatory Syndrome in Children—A Case Report

Author

Prader, Seraina, Ritz, Nicole, Baleydier, Frédéric, Andre, Maya C, Stähli, Noémie, Schmid, Kevin, Schmid, Hanna, Woerner, Andreas, Diesch, Tamara, Meyer Sauteur, Patrick M, Trück, Johannes; https://orcid.org/0000-0002-0418-7381, Gebistorf, Fabienne, Opitz, Lennart, Killian, Michael P, Marchetti, Tommaso, Vavassori, Stefano, Blanchard-Rohner, Géraldine, Mc Lin, Valerie, Grazioli, Serge, Pachlopnik Schmid, Jana; https://orcid.org/0000-0002-6653-9047, Prader, Seraina, Ritz, Nicole, Baleydier, Frédéric, Andre, Maya C, Stähli, Noémie, Schmid, Kevin, Schmid, Hanna, Woerner, Andreas, Diesch, Tamara, Meyer Sauteur, Patrick M, Trück, Johannes; https://orcid.org/0000-0002-0418-7381, Gebistorf, Fabienne, Opitz, Lennart, Killian, Michael P, Marchetti, Tommaso, Vavassori, Stefano, Blanchard-Rohner, Géraldine, Mc Lin, Valerie, Grazioli, Serge, and Pachlopnik Schmid, Jana; https://orcid.org/0000-0002-6653-9047

Abstract

Most children with a SARS-CoV-2 infection are asymptomatic or exhibit mild symptoms. However, a small number of children develop features of substantial inflammation temporarily related to the COVID-19 also called multisystem inflammatory syndrome in children (MIS-C) or pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS), clinically similar to Kawasaki disease, toxic shock syndrome and hemophagocytic lymphohistiocytosis (HLH). It is well-known that genetic pre-disposition plays an important role in virally-triggered diseases such as Epstein-Barr virus (EBV)-associated HLH, while this has not yet been established for patients with MIS-C. Here we describe a male patient fulfilling the diagnostic criteria of MIS-C, who was initially treated according to current consensus guidelines. Presence of hypofibrinogenemia, normal lymphocyte counts and C-reactive protein, but substantial hyperferritinemia distinguish this patient from others with MIS-C. The clinical course following initial presentation with acute respiratory distress syndrome was marked by fatal liver failure in the context of EBV-associated HLH despite treatment with steroids, intravenous immunoglobulins, interleukin (IL)-1 receptor blockade and eventually HLH-directed treatment. X-linked lymphoproliferative disease type 1 (XLP1), a subtype of primary HLH was diagnosed in this patient post-mortem. This case report highlights the importance of including HLH in the differential diagnosis in MIS-C with severe disease course to allow specific, risk-adapted treatment and genetic counseling.

Published
2021

29. Best Practice Recommendations for the Diagnosis and Management of Children With Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 (PIMS-TS; Multisystem Inflammatory Syndrome in Children, MIS-C) in Switzerland

Author

Schlapbach, Luregn J; https://orcid.org/0000-0003-2281-2598, Andre, Maya C, Grazioli, Serge; https://orcid.org/0000-0002-5526-851X, Schöbi, Nina, Ritz, Nicole; https://orcid.org/0000-0002-1498-1685, Aebi, Christoph; https://orcid.org/0000-0003-3554-7949, Agyeman, Philipp K A; https://orcid.org/0000-0002-8339-5444, Albisetti, Manuela, Bailey, Douggl G N, Berger, Christoph; https://orcid.org/0000-0002-1730-8824, Blanchard-Rohner, Geraldine; https://orcid.org/0000-0002-9974-2172, Bressieux-Degueldre, Sabrina, Hofer, Michael, L'Huillier, Arnaud G, Marston, Mark, Meyer Sauteur, Patrick M; https://orcid.org/0000-0002-4312-9803, Pachlopnik Schmid, Jana; https://orcid.org/0000-0002-6653-9047, Perez, Marie-Helene, Rogdo, Bjarte, Trück, Johannes; https://orcid.org/0000-0002-0418-7381, Woerner, Andreas, Wütz, Daniela; https://orcid.org/0000-0002-5186-2634, Zimmermann, Petra, Levin, Michael, Whittaker, Elizabeth, Rimensberger, Peter C, Schlapbach, Luregn J; https://orcid.org/0000-0003-2281-2598, Andre, Maya C, Grazioli, Serge; https://orcid.org/0000-0002-5526-851X, Schöbi, Nina, Ritz, Nicole; https://orcid.org/0000-0002-1498-1685, Aebi, Christoph; https://orcid.org/0000-0003-3554-7949, Agyeman, Philipp K A; https://orcid.org/0000-0002-8339-5444, Albisetti, Manuela, Bailey, Douggl G N, Berger, Christoph; https://orcid.org/0000-0002-1730-8824, Blanchard-Rohner, Geraldine; https://orcid.org/0000-0002-9974-2172, Bressieux-Degueldre, Sabrina, Hofer, Michael, L'Huillier, Arnaud G, Marston, Mark, Meyer Sauteur, Patrick M; https://orcid.org/0000-0002-4312-9803, Pachlopnik Schmid, Jana; https://orcid.org/0000-0002-6653-9047, Perez, Marie-Helene, Rogdo, Bjarte, Trück, Johannes; https://orcid.org/0000-0002-0418-7381, Woerner, Andreas, Wütz, Daniela; https://orcid.org/0000-0002-5186-2634, Zimmermann, Petra, Levin, Michael, Whittaker, Elizabeth, and Rimensberger, Peter C

Abstract

Background: Following the spread of the coronavirus disease 2019 (COVID-19) pandemic a new disease entity emerged, defined as Pediatric Inflammatory Multisystem Syndrome temporally associated with COVID-19 (PIMS-TS), or Multisystem Inflammatory Syndrome in Children (MIS-C). In the absence of trials, evidence for treatment remains scarce.Purpose: To develop best practice recommendations for the diagnosis and treatment of children with PIMS-TS in Switzerland. It is acknowledged that the field is changing rapidly, and regular revisions in the coming months are pre-planned as evidence is increasing.Methods: Consensus guidelines for best practice were established by a multidisciplinary group of Swiss pediatric clinicians with expertise in intensive care, immunology/rheumatology, infectious diseases, hematology, and cardiology. Subsequent to literature review, four working groups established draft recommendations which were subsequently adapted in a modified Delphi process. Recommendations had to reach >80% agreement for acceptance.Results: The group achieved agreement on 26 recommendations, which specify diagnostic approaches and interventions across anti-inflammatory, anti-infectious, and support therapies, and follow-up for children with suspected PIMS-TS. A management algorithm was derived to guide treatment depending on the phenotype of presentation, categorized into PIMS-TS with (a) shock, (b) Kawasaki-disease like, and (c) undifferentiated inflammatory presentation.Conclusion: Available literature on PIMS-TS is limited to retrospective or prospective observational studies. Informed by these cohort studies and indirect evidence from other inflammatory conditions in children and adults, as well as guidelines from international health authorities, the Swiss PIMS-TS recommendations represent best practice guidelines based on currently available knowledge to standardize treatment of children with suspected PIMS-TS. Given the absence of high-grade evidence, regular up

Published
2021

30. Case Report: Case Series of Children With Multisystem Inflammatory Syndrome Following SARS-CoV-2 Infection in Switzerland

Author

Fouriki, Athina, Fougère, Yves, De Camaret, Caroline, Blanchard Rohner, Géraldine, Grazioli, Serge, Wagner, Noémie, Relly, Christa, Pachlopnik Schmid, Jana; https://orcid.org/0000-0002-6653-9047, Trück, Johannes; https://orcid.org/0000-0002-0418-7381, Kottanatu, Lisa, Perez, Estefania, Perez, Marie-Helene, Schaffner, Damien, Asner, Sandra Andrea, Hofer, Michael, Fouriki, Athina, Fougère, Yves, De Camaret, Caroline, Blanchard Rohner, Géraldine, Grazioli, Serge, Wagner, Noémie, Relly, Christa, Pachlopnik Schmid, Jana; https://orcid.org/0000-0002-6653-9047, Trück, Johannes; https://orcid.org/0000-0002-0418-7381, Kottanatu, Lisa, Perez, Estefania, Perez, Marie-Helene, Schaffner, Damien, Asner, Sandra Andrea, and Hofer, Michael

Abstract

Since the beginning of the severe SARS-CoV-2 pandemic, an increasing number of countries reported cases of a systemic hyperinflammatory condition defined as multi-system inflammatory syndrome in children (MIS-C). The clinical features of MIS-C can be an overlap of Kawasaki Disease (KD), Toxic Shock Syndrome (TSS), Macrophage Activation Syndrome (MAS), or have often an acute abdominal presentation. Intravenous immunoglobulin (IVIG) is recommended as first line therapy in KD. Recent evidence suggests intravenous immunoglobulins (IVIG) resistance in some cases of SARS-CoV-2 related MIS-C, thereby questioning the benefit of immunomodulators such as IL-1 or IL-6 blocking agents. We report on a cohort of 6 Swiss children with SARS-CoV2 related MIS-C presenting with clinical features compatible with Incomplete KD and Toxic Shock Syndrome associated to a cytokine storm. Serum cytokine profile investigations showed increased IL1RA levels (8 to 22-fold) in 5 of the 6 patients (one patient had not been tested), whereas, IL-6 serum levels were increased only in the 3 patients of the 6 who were tested. With exception of one patient who had only benefited by Anakinra, all patients received at least one dose of IVIG. One patient has only received Anakinra with favorable evolution, and three patients had also a steroid treatment. In addition to all this anti-inflammatory medication two patients have also received one dose of anti-IL6. In conclusion, our case series reports on clinical and laboratory findings of most of Swiss cases with MIS-C and suggests the use of Anakinra as an alternative to steroids in these children, most of whom presented with high IL-1RA levels.

Published
2021

34. Comment on 'Beware of Too Aggressive Approach in Children With Acute Abdomen During COVID-19 Outbreak!'

Author

Calinescu, Ana M., Vidal, Isabelle, Grazioli, Serge, Lacroix, Laurence, and Wildhaber, Barbara E.

Subjects
Abdomen, Acute, Adult, Male, Infectious Disease Transmission, Patient-to-Professional, Clinical Laboratory Techniques, SARS-CoV-2, Clinical Decision-Making, Pneumonia, Viral, COVID-19, Middle Aged, Diagnosis, Differential, Betacoronavirus, COVID-19 Testing, Clinical Protocols, Humans, Female, Coronavirus Infections, Letter to the Editor, Pandemics, Personal Protective Equipment, Aged
Published
2020

35. Case Report: Case Series of Children With Multisystem Inflammatory Syndrome Following SARS-CoV-2 Infection in Switzerland

Author

Fouriki, Athina, primary, Fougère, Yves, additional, De Camaret, Caroline, additional, Blanchard Rohner, Géraldine, additional, Grazioli, Serge, additional, Wagner, Noémie, additional, Relly, Christa, additional, Pachlopnik Schmid, Jana, additional, Trück, Johannes, additional, Kottanatu, Lisa, additional, Perez, Estefania, additional, Perez, Marie-Helene, additional, Schaffner, Damien, additional, Asner, Sandra Andrea, additional, and Hofer, Michael, additional

Published
2021
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36. Immunological Assessment of Pediatric Multisystem Inflammatory Syndrome Related to Coronavirus Disease 2019

Author

Grazioli, Serge, primary, Tavaglione, Fedora, additional, Torriani, Giulia, additional, Wagner, Noemie, additional, Rohr, Marie, additional, L’Huillier, Arnaud G, additional, Leclercq, Charlotte, additional, Perrin, Anne, additional, Bordessoule, Alice, additional, Beghetti, Maurice, additional, Schmid, Jana Pachlopnik, additional, Vavassori, Stefano, additional, Perreau, Matthieu, additional, Eberhardt, Christiane, additional, Didierlaurent, Arnaud, additional, Kaiser, Laurent, additional, Eckerle, Isabella, additional, Roux-Lombard, Pascale, additional, and Blanchard-Rohner, Geraldine, additional

Published
2020
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38. Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort

Author

Wendel Garcia, Pedro David, primary, Fumeaux, Thierry, additional, Guerci, Philippe, additional, Heuberger, Dorothea Monika, additional, Montomoli, Jonathan, additional, Roche-Campo, Ferran, additional, Schuepbach, Reto Andreas, additional, Hilty, Matthias Peter, additional, Alfaro Farias, Mario, additional, Margarit, Antoni, additional, Vizmanos-Lamotte, Gerardo, additional, Tschoellitsch, Thomas, additional, Meier, Jens, additional, Cardona, Francesco S., additional, Skola, Josef, additional, Horakova, Lenka, additional, Aguirre-Bermeo, Hernan, additional, Apolo, Janina, additional, Novy, Emmanuel, additional, Losser, Marie-Reine, additional, Jurkolow, Geoffrey, additional, Delahaye, Gauthier, additional, David, Sascha, additional, Welte, Tobias, additional, Wengenmayer, Tobias, additional, Staudacher, Dawid L., additional, Aslanidis, Theodoros, additional, Babik, Barna, additional, Korsos, Anita, additional, Gal, Janos, additional, Csaba, Hermann, additional, Donati, Abele, additional, Carsetti, Andrea, additional, Turrini, Fabrizio, additional, Simonini, Maria Sole, additional, Ceriani, Roberto, additional, Murrone, Martina, additional, Rezoagli, Emanuele, additional, Vitale, Giovanni, additional, Fogagnolo, Alberto, additional, Spadaro, Savino, additional, Wu, Maddalena Alessandra, additional, Cogliati, Chiara, additional, Colombo, Riccardo, additional, Catena, Emanuele, additional, Facondini, Francesca, additional, Potalivo, Antonella, additional, Gangitano, Gianfilippo, additional, Perin, Tiziana, additional, Bocci, Maria Grazia, additional, Antonelli, Massimo, additional, Gommers, Diederik, additional, Ince, Can, additional, Mayor-Vázquez, Eric, additional, Cruz, Maria, additional, Delgado, Martin, additional, Garcia, Raquel Rodriguez, additional, Gamez Zapata, Jorge, additional, Zalba-Etayo, Begoña, additional, Lozano-Gomez, Herminia, additional, Castro, Pedro, additional, Tellez, Adrian, additional, Jacas, Adriana, additional, Muñoz, Guido, additional, Andrea, Rut, additional, Ortiz, Jose, additional, Quintana, Eduard, additional, Rovira, Irene, additional, Reverter, Enric, additional, Fernandez, Javier, additional, Ferrer, Miquel, additional, Badia, Joan R., additional, Lander Azcona, Arantxa, additional, Orta, Jesus Escos, additional, Bühler, Philipp, additional, Brugger, Silvio, additional, Hofmaenner, Daniel, additional, Unseld, Simone, additional, Ruschitzka, Frank, additional, Moret-Bochatay, Mallory, additional, Yuen, Bernd, additional, Hillermann, Thomas, additional, Ksouri, Hatem, additional, Sridharan, Govind Oliver, additional, Ristic, Anette, additional, Sepulcri, Michael, additional, Filipovic, Miodrag, additional, Pietsch, Urs, additional, Salomon, Petra, additional, Drvaric, Iris, additional, Schott, Peter, additional, Urech, Severin, additional, Lambert, Adriana, additional, Merki, Lukas, additional, Laube, Marcus, additional, Hillgaertner, Frank, additional, Sieber, Marianne, additional, Dullenkopf, Alexander, additional, Petersen, Lina, additional, Grazioli, Serge, additional, Rimensberger, Peter C., additional, Fleisch, Isabelle, additional, Lavanchy, Jerome, additional, Marquardt, Katharina, additional, Shaikh, Karim, additional, Redecker, Hermann, additional, Stephan, Michael, additional, Brem, Jan, additional, Rogdo, Bjarte, additional, Birkenmaier, Andre, additional, Meyer zu Bentrup, Friederike, additional, Fodor, Patricia, additional, Locher, Pascal, additional, Camen, Giovanni, additional, Siegemund, Martin, additional, Zellweger, Nuria, additional, Jeitziner, Marie-Madlen, additional, Jenni-Moser, Beatrice, additional, Bürkle, Christian, additional, Kleger, Gian-Reto, additional, Franchitti Laurent, Marilene, additional, Laurent, Jean-Christophe, additional, Gaspert, Tomislav, additional, Jovic, Marija, additional, Studhalter, Michael, additional, Haberthuer, Christoph, additional, Lussman, Roger F., additional, Selz, Daniela, additional, Naon, Didier, additional, Mauri, Romano, additional, Ceruti, Samuele, additional, Marrel, Julien, additional, Brenni, Mirko, additional, Ensner, Rolf, additional, Gehring, Nadine, additional, Heise, Antje, additional, Huebner, Tobias, additional, Neff, Thomas A., additional, Cereghetti, Sara, additional, Boroli, Filippo, additional, Pugin, Jerome, additional, Marczin, Nandor, additional, and Wong, Joyce, additional

Published
2020
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39. Immunological Assessment of Pediatric Multisystem Inflammatory Syndrome Related to Coronavirus Disease 2019.

Author

Grazioli, Serge, Tavaglione, Fedora, Torriani, Giulia, Wagner, Noemie, Rohr, Marie, L'Huillier, Arnaud G, Leclercq, Charlotte, Perrin, Anne, Bordessoule, Alice, Beghetti, Maurice, Schmid, Jana Pachlopnik, Vavassori, Stefano, Perreau, Matthieu, Eberhardt, Christiane, Didierlaurent, Arnaud, Kaiser, Laurent, Eckerle, Isabella, Roux-Lombard, Pascale, and Blanchard-Rohner, Geraldine

Subjects
*REVERSE transcriptase polymerase chain reaction, *CYTOKINES, *INTERLEUKINS, *COVID-19, *IMMUNOGLOBULINS, *MULTIPLE organ failure, *IMMUNE system, *KILLER cells, *GENE expression, *ENZYME-linked immunosorbent assay, *FLUORESCENT antibody technique, *POLYMERASE chain reaction, *VIROLOGY, *CHILDREN
Abstract

Background Recently, cases of multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19) have been reported worldwide. Negative polymerase chain reaction (RT-PCR) testing associated with positive serology in most of the cases suggests a postinfectious syndrome. Because the pathophysiology of this syndrome is still poorly understood, extensive virological and immunological investigations are needed. Methods We report a series of 4 pediatric patients admitted to Geneva University Hospitals with persistent fever and laboratory evidence of inflammation meeting the published definition of MIS-C related to COVID-19, to whom an extensive virological and immunological workup was performed. Results RT-PCRs on multiple anatomical compartments were negative, whereas anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin A (IgA) and immunoglobulin G (IgG) were strongly positive by enzyme-linked immunosorbent assay and immunofluorescence. Both pseudoneutralization and full virus neutralization assays showed the presence of neutralizing antibodies in all children, confirming a recent infection with SARS-CoV-2. The analyses of cytokine profiles revealed an elevation in all cytokines, as reported in adults with severe COVID-19. Although differing in clinical presentation, some features of MIS-C show phenotypic overlap with hemophagocytic lymphohistiocytosis (HLH). In contrast to patients with primary HLH, our patients showed normal perforin expression and natural killer (NK) cell degranulation. The levels of soluble interleukin (IL)-2 receptor (sIL-2R) correlated with the severity of disease, reflecting recent T-cell activation. Conclusion Our findings suggest that MIS-C related to COVID-19 is caused by a postinfectious inflammatory syndrome associated with an elevation in all cytokines, and markers of recent T-cell activation (sIL-2R) occurring despite a strong and specific humoral response to SARS-CoV-2. Further functional and genetic analyses are essential to better understand the mechanisms of host–pathogen interactions. [ABSTRACT FROM AUTHOR]

Published
2021
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40. Viral co-infections among SARS-CoV-2-infected children and infected adult household contacts.

Author

Pigny, Fiona, Wagner, Noémie, Rohr, Marie, Mamin, Aline, Cherpillod, Pascal, Posfay-Barbe, Klara M., Kaiser, Laurent, Eckerle, Isabella, L'Huillier, Arnaud G., for the Geneva Pediatric COVID Group, Gervaix, Alain, Lacroix, Laurence, Haddad, Kevin, Wagner, Noemie, Pinosch, Selina, Grazioli, Serge, Pfister, Riccardo, Widlhaber, Barbara, Beghetti, Maurice, and Maggio, Albane

Subjects
MIXED infections, HOUSEHOLDS, SARS-CoV-2, STAY-at-home orders, SCHOOL closings
Abstract

We evaluated the rates of viral respiratory co-infections among SARS-CoV-2-infected children. Twelve percent of SARS-CoV-2-infected children had viral co-infection with one or more common respiratory viruses. This was significantly more frequent than among their SARS-CoV-2-infected adult household contacts (0%; p=0.028). Compared to the same period the previous year, common respiratory viruses were less frequently detected (12% vs 73%, p<0.001). Conclusion: Despite partial lockdown with school and daycare closure, and consequently similar exposure to common viruses between children and adults, SARS-CoV-2-infected children had more frequent viral respiratory co-infections than their SARS-CoV-2-infected adult household contacts. Circulation of common respiratory viruses was less frequent during the SARS-CoV-2 outbreak when compared to the same period last year, showing the impact of partial lockdown on the circulation of common viruses. What is Known: • Viral respiratory co-infections are frequent in children. • SARS-CoV-2 can be identified alongside other respiratory viruses, but data comparing children and adults are lacking. What is New: • Children infected with SARS-CoV-2 are more likely to have viral respiratory co-infections than their SARS-CoV-2-infected adult household contacts, which is surprising in the context of partial lockdown with schools and daycare closed. • When compared to data collected during the same period last year, our study also showed that partial lockdown reduced circulation of common respiratory viruses. [ABSTRACT FROM AUTHOR]

Published
2021
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42. Antenatal and postnatal ultrasound in the evaluation of the risk of vesicoureteral reflux

Author

Grazioli, Serge, Parvex, Paloma, Merlini, Laura, Combescure, Christophe, Girardin, Eric, Grazioli, Serge, Parvex, Paloma, Merlini, Laura, Combescure, Christophe, and Girardin, Eric

Abstract

Antenatal hydronephrosis (ANH) is a frequent anomaly detected on fetal ultrasound scans. There is no consensus recommendation for the postnatal follow-up and/or the necessity to perform a voiding cystourethrography (VCUG) to diagnose vesicoureteral reflux (VUR). We conducted a cohort/non-randomized trial of 121 patients with ANH, defined as an anterior posterior diameter (APD) ≥5mm after the 20th week of gestation, to evaluate the ability of the antenatal and postnatal ultrasonography results to predict VUR. All infants had two successive ultrasounds at 5days and 1month, respectively, after birth. A VCUG was performed at 6weeks in children with a persistent APD ≥5mm and/or an ureteral dilatation observed on at least one of two postnatal ultrasounds. In total, 88 patients had VCUG and nine had VUR, with five having high-grade reflux (>grade II). The risk of VUR increased significantly with the degree of APD detected on the postnatal ultrasound scan (p = 0.03). The odds ratios were 5.0 [95% confidence interval (CI) 0.5-51.2] for APD = 7-9mm and 9.1 (95% CI 1.0-80.9) for APD ≥10mm. The results of this study show that among our patient cohort antenatal ultrasound was not predictive of reflux. There was, however, a relation between the importance of the postnatal renal pelvis diameter and the risk of VUR. A cut-off of 7mm showed a fair ability of ultrasonography to predict VUR and a cut-off of 10mm enabled all severe refluxes in the 88 patients who had a VCUG to be diagnosed

Published
2018

45. Phenotypic expansion of TBX4 mutations to include acinar dysplasia of the lungs

Author

Szafranski, Przemyslaw, primary, Coban‐Akdemir, Zeynep H., additional, Rupps, Rosemarie, additional, Grazioli, Serge, additional, Wensley, David, additional, Jhangiani, Shalini N., additional, Popek, Edwina, additional, Lee, Anna F., additional, Lupski, James R., additional, Boerkoel, Cornelius F., additional, and Stankiewicz, Paweł, additional

Published
2016
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46. Rôle de l'ultrason anténatal et postnatal dans l'évaluation du risque de reflux vésico-urétéral

Author

Grazioli, Serge and Girardin, Eric

Subjects
Reflux vésico-urétéral, ddc:618, Ultrason, Hydronéphrose
Abstract

L'hydronéphrose anténatale se définit par une dilatation du système pyélocaliciel rénal et représente une des anomalies les plus fréquentes découverte à l'ultrason anténatal. Bien que les formes mineures soient la plupart du temps physiologiques et transitoires, la présence d'une dilatation du système pyélocaliciel peut néanmoins être associée à une uropathie obstructive ou à un reflux vésico-urétéral. L'importance de la dilatation se quantifie par la mesure en cm du diamètre antéro-postérieure (AP) de celle-ci. A l'heure actuelle, il n'existe aucun consensus dans la littérature concernant le diamètre AP à partir duquel il est indiqué d'effectuer un suivi postnatal et un dépistage systématique à la recherche d'un reflux vésico-urétéral lors de la découverte d'une hydronéphrose anténatale de forme mineure (diamètre antéro-postérieur du bassinet < 10mm). Cette situation engendre pour le nourrisson un nombre important d'examens invasifs et irradiants inutiles associés à un stress parental considérable. Le but de cette étude est d'évaluer de manière prospective l'habileté de l'échographie anténatale et postnatale à sélectionner les enfants à risque de présenter un reflux vésico-urétéral en fonction du diamètre AP à l'ultrason. Notre recherche a permis de démontrer que le risque de présenter un reflux vésico-urétéral était mieux corrélé avec le résultat des ultrasons postnataux que ceux des US anténataux et que ce risque augmente de manière significative en fonction du degré de dilatation pyélocalicielle présent sur l'ultrason postnatal. Ces données confirment l'utilité de l'ultrason postnatal comme examen de dépistage du reflux vésico-urétéral pour les enfants ayant présenté une hydronéphrose anténatale de forme mineure.

Published
2011
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48. CYR61 (CCN1) overexpression induces lung injury in mice

Author

Grazioli, Serge, primary, Gil, Sucheol, additional, An, Dowon, additional, Kajikawa, Osamu, additional, Farnand, Alex W., additional, Hanson, Josiah F., additional, Birkland, Timothy, additional, Chen, Peter, additional, Duffield, Jeremy, additional, Schnapp, Lynn M., additional, Altemeier, William A., additional, and Matute-Bello, Gustavo, additional

Published
2015
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