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258 results on '"Graziano, V."'

3. C5 - Efficacy of pertuzumab in combination with trastuzumab and a taxane in in first line treatment for metastatic breast cancer (MBC): a multicenter retrospective observational study

Author

Mentuccia, L., Gelibter, A., Sperduti, I., D'Onofrio, L., Botticelli, A., Vici, P., Cassano, A., Moscetti, L., Carbognin, L., Graziano, V., Barchiesi, G., Rossi, E., Cursano, M.C., Pizzuti, L., Paris, I., Vaccaro, A., Fabbri, A., Rossi, L., Samaritani, R., Sarmiento, R., and Gamucci, T.

Published
2017
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4. Association of low-penetrance alleles with male breast cancer risk and clinicopathological characteristics: results from a multicenter study in Italy

Author

Ottini, L., Silvestri, V., Saieva, C., Rizzolo, P., Zanna, I., Falchetti, M., Masala, G., Navazio, A. S., Graziano, V., Bianchi, S., Manoukian, S., Barile, M., Peterlongo, P., D’Amico, C., Varesco, L., Tommasi, S., Russo, A., Giannini, G., Cortesi, L., Viel, A., Montagna, M., Radice, P., and Palli, D.

Published
2013
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7. Corrigendum to “Circulating Cancer Stem Cell-Derived Extracellular Vesicles as a Novel Biomarker for Clinical Outcome Evaluation”

Author

Brocco, D., primary, Lanuti, P., additional, Simeone, P., additional, Bologna, G., additional, Pieragostino, D., additional, Cufaro, M. C., additional, Graziano, V., additional, Peri, M., additional, Di Marino, P., additional, De Tursi, M., additional, Grassadonia, A., additional, Rapposelli, I. G., additional, Pierdomenico, L., additional, Ercolino, E., additional, Ciccocioppo, F., additional, Del Boccio, P., additional, Marchisio, M., additional, Natoli, C., additional, Miscia, S., additional, and Tinari, N., additional

Published
2020
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8. Histone H1 is located in the interior of the chromatin 30-nm filament

Author

Graziano, V., Gerchman, S.E., Schneider, D.K., and Ramakrishnan, V.

Subjects
Histones -- Analysis, Chromatin -- Analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Nucleosomes are bound by the linker histone H1 which is necessary for their organization as filaments. The linker histone is located inside the chromatin filament. Cell-dependent chromatin decondensation and condensation involves the phosphorylation process of H1.

Published
1994

9. Crystal structure of globular domain of histone H5 and its implications for nucleosome binding

Author

Ramakrishnan, V., Finch, J.T., Graziano, V., Lee, P.L., and Sweett, R.M.

Subjects
DNA binding proteins -- Research, Nucleoproteins -- Research, Histones -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

A model for the binding of histone H5 to nucleosomal DNA is presented based onits similarity with the catabolite gene activator protein. The crystal structure of GH5, the globular domain of H5, was determined using muliwavelength anomalous diffraction. Observations indicate the presence of a secondary binding site. This could be used for experiments dealing with site-directed mutagenesis and co-crystallization.

Published
1993

10. Circulating Cancer Stem Cell-Derived Extracellular Vesicles as a Novel Biomarker for Clinical Outcome Evaluation

Author

Brocco, D., primary, Lanuti, P., additional, Simeone, P., additional, Bologna, G., additional, Pieragostino, D., additional, Cufaro, M. C., additional, Graziano, V., additional, Peri, M., additional, Di Marino, P., additional, De Tursi, M., additional, Grassadonia, A., additional, Rapposelli, I. G., additional, Pierdomenico, L., additional, Ercolino, E., additional, Ciccocioppo, F., additional, Del Boccio, P., additional, Marchisio, M., additional, Natoli, C., additional, Miscia, S., additional, and Tinari, N., additional

Published
2019
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14. Assisted reproductive technologies in the relationship between the legislator and the constitutional court [La procreazione medicalmente assistita nel rapporto tra legislatore e corte costituzionale]

Author

Casella, C., Niola, M., Graziano, V., Paternoster, M., Di Lorenzo, P., Buccelli, C., Casella, C., Niola, M., Graziano, V., Paternoster, M., Di Lorenzo, P., and Buccelli, C.

Subjects
Diagnosi genetica preimpianto, Sperimentazione, Maternità surrogata, Procreazione medicalmente assistita, Fecondazione eterologa, Embrioni soprannumerari
Published
2017

16. LOCAL RECURRENCE OF ENDOSCOPIC ROBOTIC ASSISTED SIMPLE ENUCLEATION (ERASE) FOR RENAL CELL CARCINOMA ACCORDING TO PATHOLOGICAL CHARACTERISTICS OF PERITUMORAL PSEUDOCAPSULE: RISULTATI AT A MIDTERM FOLLOW-UP

Author

Tellini, R., Campi, R., Mari, A., Raspollini, Maria Rosaria, Francesco, S., Bigazzi, B., Pietro, S., Graziano, V., Facchiano, D., Xhaferi, R., Lapini, A., Tuccio, Agostino, Carini, Marco, and Minervini, Andrea

Subjects
LOCAL RECURRENCE, ENDOSCOPIC ROBOTIC ASSISTED SIMPLE ENUCLEATION, (RENAL CELL CARCINOMA
Published
2016

17. Efficacy of pertuzumab in combination with trastuzumab and a taxane in in first line treatment for metastatic breast cancer (MBC): a multicenter retrospective observational study

Author

Mentuccia, L., primary, Gelibter, A., additional, Sperduti, I., additional, D'Onofrio, L., additional, Botticelli, A., additional, Vici, P., additional, Cassano, A., additional, Moscetti, L., additional, Carbognin, L., additional, Graziano, V., additional, Barchiesi, G., additional, Rossi, E., additional, Cursano, M.C., additional, Pizzuti, L., additional, Paris, I., additional, Vaccaro, A., additional, Fabbri, A., additional, Rossi, L., additional, Samaritani, R., additional, Sarmiento, R., additional, and Gamucci, T., additional

Published
2017
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19. Complete Response and Long-term Survival in Malignant Pleural Mesothelioma: Case Report

Author

silvia takanen, Resuli, B., Graziano, V., Parisi, A., Lisi, R., Raffetto, N., and Tombolini, V.

Subjects
Adult, Mesothelioma, Guanine, Pleural Neoplasms, Pemetrexed, Combined Modality Therapy, Disease-Free Survival, organization, long-term survival, asbestos, malignant pleural mesothelioma, trimodality therapy, extrapleural pneumonectomy, multidisciplinary treatment, Treatment Outcome, Glutamates, Positron-Emission Tomography, Antineoplastic Combined Chemotherapy Protocols, Humans, Female, Cisplatin
Abstract

Malignant pleural mesothelioma is a rare tumour. A three-modal strategy, comprising of surgery, radiotherapy and chemotherapy has been shown to be essential for appropriate management. Current literature evidences the importance of radiation therapy in the adjuvant setting for local control of the disease, as part of a multidisciplinary treatment, with increment of progression-free survival rate, but also of disease-free survival.At the beginning of 2007, a 26-year-old Peruvian woman was admitted to the hospital referring breathlessness and other non-specific symptoms such as fever and weight loss. After the diagnosis of pleural mesothelioma by thoracoscopic talc insufflation, combined with pleural biopsy, and total body computed tomographic scan, the patient underwent two cycles of neoadjuvant chemotherapy with pemetrexed (500 mg/m(2)) and cisplatin (75 mg/m(2)), followed by an extra-pleural pneumonectomy. After 6 months, the patient was treated with three-dimensional external beam radiation therapy to the left hemithorax. Computed tomographic scans, performed after the ending of the radiotherapy, integrated with positron-emission tomography, were all negative for neoplastic pathology. The patient remains in good health and free from recurrence at four years.This clinical case shows a disease-free survival interval of 4 years for malignant pleural mesothelioma. A good staging system and a combined treatment, involving surgery, neoadjuvant chemotherapy and adjuvant radiation therapy, represent a useful strategy not only to contain local disease progression, but even to increase disease-free survival in pleural mesothelioma.

Published
2012

22. Neutropenia and breast cancer outcome

Author

Ricciardi, S., Graziano, V., Rosati, M. S., Ranuncoli, A., Tomao, Federica, Proietti, E., Cerbone, L., Recine, F., and Di seri, M.

Published
2005

24. Nucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNA

Author

Chiarella, S, De Cola, A, Scaglione, Giovanni Luca, Carletti, E, Graziano, V, Barcaroli, D, Lo Sterzo, C, Di Matteo, A, Di Ilio, C, Falini, B, Arcovito, Alessandro, De Laurenzi, V, Federici, L., Arcovito, Alessandro (ORCID:0000-0002-8384-4844), Chiarella, S, De Cola, A, Scaglione, Giovanni Luca, Carletti, E, Graziano, V, Barcaroli, D, Lo Sterzo, C, Di Matteo, A, Di Ilio, C, Falini, B, Arcovito, Alessandro, De Laurenzi, V, Federici, L., and Arcovito, Alessandro (ORCID:0000-0002-8384-4844)

Abstract

Nucleophosmin (NPM1) is an abundant nucleolar protein implicated in ribosome maturation and export, centrosome duplication and response to stress stimuli. NPM1 is the most frequently mutated gene in acute myeloid leukemia. Mutations at the C-terminal domain led to variant proteins that aberrantly and stably translocate to the cytoplasm. We have previously shown that NPM1 C-terminal domain binds with high affinity G-quadruplex DNA. Here, we investigate the structural determinants of NPM1 nucleolar localization. We show that NPM1 interacts with several G-quadruplex regions found in ribosomal DNA, both in vitro and in vivo. Furthermore, the most common leukemic NPM1 variant completely loses this activity. This is the consequence of G-quadruplex-binding domain destabilization, as mutations aimed at refolding the leukemic variant also result in rescuing the G-quadruplex-binding activity and nucleolar localization. Finally, we show that treatment of cells with a G-quadruplex selective ligand results in wild-type NPM1 dislocation from nucleoli into nucleoplasm. In conclusion, this work establishes a direct correlation between NPM1 G-quadruplex binding at rDNA and its nucleolar localization, which is impaired in the acute myeloid leukemia-associated protein variants.

Published
2013

25. 731 Gene Copy Number Alterations in Male Breast Tumors

Author

Rizzolo, P., primary, Navazio, A.S., additional, Falchetti, M., additional, Silvestri, V., additional, Graziano, V., additional, Zanna, I., additional, Tommasi, S., additional, Paradiso, A.S., additional, Palli, D., additional, and Ottini, L., additional

Published
2012
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32. Oral Poster 12

Author

Pathi, S. D., primary, Sailors, J., additional, Graziano, V., additional, Sims, R., additional, Stone, R., additional, McIntire, D. D., additional, Rahn, D. D., additional, and Wai, C. Y., additional

Published
2010
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