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Your search keyword '"Graziano, Adriana C.E."' showing total 15 results
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15 results on '"Graziano, Adriana C.E."'

7. A molecular hybrid producing simultaneously singlet oxygen and nitric oxide by single photon excitation with green light

Author

Parisi, Cristina, primary, Failla, Mariacristina, additional, Fraix, Aurore, additional, Rescifina, Antonio, additional, Rolando, Barbara, additional, Lazzarato, Loretta, additional, Cardile, Venera, additional, Graziano, Adriana C.E., additional, Fruttero, Roberta, additional, Gasco, Alberto, additional, and Sortino, Salvatore, additional

Published
2019
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13. Comparison of essential oil components and in vitro anticancer activity in wild and cultivated Salvia verbenaca.

Author

Russo, Alessandra, Cardile, Venera, Graziano, Adriana C.E., Formisano, Carmen, Rigano, Daniela, Canzoneri, Marisa, Bruno, Maurizio, and Senatore, Felice

Abstract

The objectives of our research were to study the chemical composition and the in vitro anticancer effect of the essential oil of Salvia verbenaca growing in natural sites in comparison with those of cultivated (Sc) plants. The oil from wild (Sw) S. verbenaca presented hexadecanoic acid (23.1%) as the main constituent, while the oil from Sc plants contained high quantities of hexahydrofarnesyl acetone (9.7%), scarce in the natural oil (0.7%). The growth-inhibitory and proapoptotic effects of the essential oils from Sw and Sc S. verbenaca were evaluated in the human melanoma cell line M14, testing cell vitality, cell membrane integrity, genomic DNA fragmentation and caspase-3 activity. Both the essential oils were able to inhibit the growth of the cancer cells examined inducing also apoptotic cell death, but the essential oil from cultivated samples exhibited the major effects. [ABSTRACT FROM AUTHOR]

Published
2015
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15. Effect of Three CentaureaSpecies Collected from Central Anatolia Region of Turkey on Human Melanoma Cells

Author

Russo, Alessandra, Cardile, Venera, Graziano, Adriana C.E., Rigano, Daniela, Aktumsek, Abdurrahman, Zengin, Gokhan, and Senatore, Felice

Abstract

Centaureais the largest genus within the Asteraceae family. Many members of this genus are used in traditional folk medicine, such as Centaurea pulchellaused to treat skin problems such as to resolve the abscess. Although biological activities of many Centaureaspecies have been investigated in different countries and Turkey, cytotoxic effect of C. patula, C. pulchellaand C. tchihatcheffiihas not been studied yet. Melanoma is one of the most invasive and deadly forms of skin cancer. Therefore, in an ongoing effort to identify new natural anticancer products for the treatment and/or prevention of melanoma cancer, the present study was undertaken to investigate the effect of these Centaureaspecies, collected from Central Anatolia region of Turkey on cell growth and death in human melanoma cell line, A375. The results revealed that all extractswere able to inhibit, after 48 h of treatment, the growth of cancer cells, that could be related to an overall action of the phenolic compounds present. In fact, C. pulchella, with the highest level of phenolics, showed a major activity followed by C. patulaand C. tchihatcheffii. Our data also demonstrate that these natural products induce apoptotic cell death. In conclusion, the study of plant extracts for their cytotoxic and apoptotic properties has shown that medicinal herbs from Centaureaspecies might have also importance in the prevention and treatment of melanoma.

Published
2016
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