857 results on '"Graziani F."'
Search Results
2. First bromine doped cryogenic implosion at the National Ignition Facility
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Hayes, A. C., Kyrala, G., Gooden, M., Wilhelmy, J. B., Kot, L., Volegov, P., Wilde, C., Haines, B., Jungman, Gerard, Rundberg, R. S., Wilson, D. C., Velsko, C., Cassata, W., Henry, E., Yeamans, C., Cerjan, C., Ma, T., Doppner, T., Nikroo, A., Hurricane, O., Callahan, D., Hinkel, D., Schneider, D., Bachmann, B., Graziani, F., Chen, K. C., Kong, C., Huang, H., Crippen, J. W., Ratledge, M., Rice, N. G., and Farrell, M. P.
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Physics - Plasma Physics ,Nuclear Experiment - Abstract
We report on the first experiment dedicated to the study of nuclear reactions on dopants in a cryogenic capsule at the National Ignition Facility (NIF). This was accomplished using bromine doping in the inner layers of the CH ablator of a capsule identical to that used in the NIF shot N140520. The capsule was doped with 3$\times$10$^{16}$ bromine atoms. The doped capsule shot, N170730, resulted in a DT yield that was 2.6 times lower than the undoped equivalent. The Radiochemical Analysis of Gaseous Samples (RAGS) system was used to collect and detect $^{79}$Kr atoms resulting from energetic deuteron and proton ion reactions on $^{79}$Br. RAGS was also used to detect $^{13}$N produced dominantly by knock-on deuteron reactions on the $^{12}$C in the ablator. High-energy reaction-in-flight neutrons were detected via the $^{209}$Bi(n,4n)$^{206}$Bi reaction, using bismuth activation foils located 50 cm outside of the target capsule. The robustness of the RAGS signals suggest that the use of nuclear reactions on dopants as diagnostics is quite feasible.
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- 2023
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3. Quantum Computing for Fusion Energy Science Applications
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Joseph, I., Shi, Y., Porter, M. D., Castelli, A. R., Geyko, V. I., Graziani, F. R., Libby, S. B., and DuBois, J. L.
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Quantum Physics ,Mathematical Physics ,Physics - Plasma Physics ,68Q12, 81P68 ,F.2 ,J.2 - Abstract
This is a review of recent research exploring and extending present-day quantum computing capabilities for fusion energy science applications. We begin with a brief tutorial on both ideal and open quantum dynamics, universal quantum computation, and quantum algorithms. Then, we explore the topic of using quantum computers to simulate both linear and nonlinear dynamics in greater detail. Because quantum computers can only efficiently perform linear operations on the quantum state, it is challenging to perform nonlinear operations that are generically required to describe the nonlinear differential equations of interest. In this work, we extend previous results on embedding nonlinear systems within linear systems by explicitly deriving the connection between the Koopman evolution operator, the Perron-Frobenius evolution operator, and the Koopman-von Neumann evolution (KvN) operator. We also explicitly derive the connection between the Koopman and Carleman approaches to embedding. Extension of the KvN framework to the complex-analytic setting relevant to Carleman embedding, and the proof that different choices of complex analytic reproducing kernel Hilbert spaces depend on the choice of Hilbert space metric are covered in the appendices. Finally, we conclude with a review of recent quantum hardware implementations of algorithms on present-day quantum hardware platforms that may one day be accelerated through Hamiltonian simulation. We discuss the simulation of toy models of wave-particle interactions through the simulation of quantum maps and of wave-wave interactions important in nonlinear plasma dynamics., Comment: 42 pages; 12 figures; invited paper at the 2021-2022 International Sherwood Fusion Theory Conference
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- 2022
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4. Shock Physics in Warm Dense Matter--a quantum hydrodynamics perspective
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Graziani, F., Moldabekov, Z., Olson, B., and Bonitz, M.
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Physics - Plasma Physics ,Astrophysics - High Energy Astrophysical Phenomena ,Physics - Fluid Dynamics - Abstract
Warm dense matter (WDM)--an exotic, highly compressed state of matter between solid and plasma phases is of high current interest, in particular for astrophysics and inertial confinement fusion. For the latter, in particular the propagation of compression shocks is crucial. The main unknown in the shock propagation in WDM is the behavior of the electrons since they are governed by correlations, quantum and spin effects that need to be accounted for simultaneously. Here we describe the shock dynamics of the warm dense electron gas using a quantum hydrodynamic model. From the numerical hydrodynamic simulations we observe that the quantum Bohm pressure induces shear force which weakens the formation and strength of the shock. This is confirmed by the theoretical analysis of the early stage of the shock formation. Our theoretical and numerical analysis allows us to identify characteristic dimensionless shock propagation parameters at which the effect of the Bohm force is important.
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- 2021
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5. Towards a Quantum Fluid Theory of Correlated Many-Fermion Systems from First Principles
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Moldabekov, Zh. A., Dornheim, T., Gregori, G., Graziani, F., Bonitz, M., and Cangi, A.
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Physics - Plasma Physics ,Condensed Matter - Quantum Gases ,Condensed Matter - Strongly Correlated Electrons - Abstract
Correlated many-fermion systems emerge in a broad range of phenomena in warm dense matter, plasmonics, and ultracold atoms. Quantum hydrodynamics (QHD) complements common first-principles methods for many-fermion systems and enables simulations at larger length and longer time scales. While the quantum Bohm potential is central to QHD, we illustrate its failure for strong perturbations. We extend QHD to this regime by utilizing the many-fermion quantum Bohm potential. This opens up the path to more accurate simulations in strongly perturbed warm dense matter, inhomogeneous quantum plasmas, and on nano-structure surfaces at scales unattainable with first-principles algorithms. The many-fermion quantum Bohm potential might also have important astrophysical applications in developing conformal-invariant cosmologies.
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- 2021
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6. Review of the First Charged-Particle Transport Coefficient Comparison Workshop
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Grabowski, P. E., Hansen, S. B., Murillo, M. S., Stanton, L. G., Graziani, F. R., Zylstra, A. B., Baalrud, S. D., Arnault, P., Baczewski, A. D., Benedict, L. X., Blancard, C., Certik, O., Clerouin, J., Collins, L. A., Copeland, S., Correa, A. A., Dai, J., Daligault, J., Desjarlais, M. P., Dharma-wardana, M. W. C., Faussurier, G., Haack, J., Haxhimali, T., Hayes-Sterbenz, A., Hou, Y., Hu, S. X., Jensen, D., Jungman, G., Kagan, G., Kang, D., Kress, J. D., Ma, Q., Marciante, M., Meyer, E., Rudd, R. E., Saumon, D., Shulenburger, L., Singleton Jr., R. L., Sjostrom, T., Stanek, L. J., Starrett, C. E., Ticknor, C., Valaitis, S., Venzke, J., and White, A.
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Physics - Plasma Physics - Abstract
We present the results of the first Charged-Particle Transport Coefficient Code Comparison Workshop, which was held in Albuquerque, NM October 4-6, 2016. In this first workshop, scientists from eight institutions and four countries gathered to compare calculations of transport coefficients including thermal and electrical conduction, electron-ion coupling, inter-ion diffusion, ion viscosity, and charged particle stopping powers. Here, we give general background on Coulomb coupling and computational expense, review where some transport coefficients appear in hydrodynamic equations, and present the submitted data. Large variations are found when either the relevant Coulomb coupling parameter is large or computational expense causes difficulties. Understanding the general accuracy and uncertainty associated with such transport coefficients is important for quantifying errors in hydrodynamic simulations of inertial confinement fusion and high-energy density experiments., Comment: 45 pages, 17 figures
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- 2020
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7. Effects of drive pulse shape on graded metal pushered single shell capsule implosions on the National Ignition Facility
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Dewald, E. L., primary, MacLaren, S. A., additional, Ho, D. D.-M., additional, Martinez, D. A., additional, Pino, J. E., additional, Tipton, R. E., additional, Young, C. V., additional, Horwood, C., additional, Divol, L., additional, Rubery, M. S., additional, Moore, A., additional, Vazsonyi, A. R., additional, Mellos, G., additional, Montgomery, W., additional, Smalyuk, V. A., additional, Graziani, F., additional, Monzon, E., additional, Prisbrey, S. T., additional, Whitley, H. D., additional, Xu, H., additional, Huang, H., additional, Kong, C., additional, Ratledge, M., additional, Volegov, P., additional, Freeman, M. S., additional, Wilde, C., additional, and Meaney, K., additional
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- 2024
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8. A Photometry Method for Fast-Rotating Artificial Satellites Using a Slow Read-Out CCD Camera
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Schmalz, S. E., Novichonok, A. O., Voropaev, V. A., Graziani, F., Abdel-Aziz, Y., Abdelaziz, A. M., and Tealib, S. K.
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- 2021
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9. Quantum hydrodynamics for plasmas -- a Thomas-Fermi theory perspective
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Michta, D., Graziani, F., and Bonitz, M.
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Physics - Plasma Physics - Abstract
The idea to describe quantum systems within a hydrodynamic framework (quantum hydrodynamics, QHD) goes back to Madelung and Bohm. While such a description is formally exact for a single particle, more recently the concept has been applied to many-particle systems by Manfredi and Haas [Phys. Rev. B {\bf 64}, 075316 (2001)] and received high popularity in parts of the quantum plasma community. Thereby, often the applicability limits of these equations are ignored, giving rise to unphysical predictions. Here we demonstrate that modified QHD equations for plasmas can be derived from Thomas-Fermi theory including gradient corrections. This puts QHD on firm grounds. At the same time this derivation yields a different prefactor, $\gamma=(D-2/3D)$, in front of the quantum (Bohm) potential which depends on the system dimensionality $D$. Our approach allows one to identify the limitations of QHD and to outline systematic improvements.
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- 2015
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10. Electrocardiographic evolution in Anderson-Fabry disease: a valuable tool to detect progressive cardiac involvement
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Baldassarre, R, primary, Parisi, V, additional, Di Taranto, R, additional, Barlocco, F, additional, Lillo, R, additional, Re, F, additional, Marchi, G, additional, Di Nicola, F, additional, Barile, L, additional, Schiavo, M A, additional, Gimeno Blanes, J R, additional, Graziani, F, additional, Olivotto, I, additional, Galie', N, additional, and Biagini, E, additional
- Published
- 2023
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11. A novel hemodynamic index characterizing mitral regurgitation undergoing transcatheter edge to edge repair: the mitral pulse pressure fraction
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Leone, A M, primary, Di Giusto, F, additional, Lucarelli, K, additional, Vicere, A, additional, Anastasia, G, additional, Galante, D, additional, Petrolati, E, additional, Burzotta, F, additional, Aurigemma, C, additional, Lombardo, A, additional, Locorotondo, G, additional, Graziani, F, additional, Casamassima, V, additional, Grimaldi, M, additional, and Trani, C, additional
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- 2023
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12. Electrocardiogram evolution in Anderson-Fabry disease patients during follow-up
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Parisi, V, primary, Di Nicola, F, additional, Lillo, R, additional, Marchi, G, additional, Gimeno Blanes, J R, additional, Re, F, additional, Chiti, C, additional, Ditaranto, R, additional, Baldassarre, R, additional, Schiavo, M A, additional, Taglieri, N, additional, Galie', N, additional, Graziani, F, additional, Olivotto, I, additional, and Biagini, E, additional
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- 2023
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13. Plasma stopping-power measurements reveal transition from non-degenerate to degenerate plasmas
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Hayes, A. C., Gooden, M. E., Henry, E., Jungman, Gerard, Wilhelmy, J. B., Rundberg, R. S., Yeamans, C., Kyrala, G., Cerjan, C., Danielson, D. L., Daligault, Jérôme, Wilburn, C., Volegov, P., Wilde, C., Batha, S., Bredeweg, T., Kline, J. L., Grim, G. P., Hartouni, E. P., Shaughnessy, D., Velsko, C., Cassata, W. S., Moody, K., Berzak Hopkins, L. F., Hinkel, D., Döppner, T., Le Pape, S., Graziani, F., Callahan, D. A., Hurricane, O. A., and Schneider, D.
- Published
- 2020
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14. Effect of Migalastat on cArdiac Involvement in FabRry Disease: MAIORA study
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Camporeale, A, Bandera, F, Pieroni, M, Pieruzzi, F, Spada, M, Bersano, A, Econimo, L, Lanzillo, C, Rubino, M, Mignani, R, Motta, I, Olivotto, I, Tanini, I, Valaperta, R, Chow, K, Baroni, I, Boveri, S, Graziani, F, Pica, S, Tondi, L, Guazzi, M, Lombardi, M, Camporeale A., Bandera F., Pieroni M., Pieruzzi F., Spada M., Bersano A., Econimo L., Lanzillo C., Rubino M., Mignani R., Motta I., Olivotto I., Tanini I., Valaperta R., Chow K., Baroni I., Boveri S., Graziani F., Pica S., Tondi L., Guazzi M., Lombardi M., Camporeale, A, Bandera, F, Pieroni, M, Pieruzzi, F, Spada, M, Bersano, A, Econimo, L, Lanzillo, C, Rubino, M, Mignani, R, Motta, I, Olivotto, I, Tanini, I, Valaperta, R, Chow, K, Baroni, I, Boveri, S, Graziani, F, Pica, S, Tondi, L, Guazzi, M, Lombardi, M, Camporeale A., Bandera F., Pieroni M., Pieruzzi F., Spada M., Bersano A., Econimo L., Lanzillo C., Rubino M., Mignani R., Motta I., Olivotto I., Tanini I., Valaperta R., Chow K., Baroni I., Boveri S., Graziani F., Pica S., Tondi L., Guazzi M., and Lombardi M.
- Abstract
Background: A small but significant reduction in left ventricular (LV) mass after 18 months of migalastat treatment has been reported in Fabry disease (FD). This study aimed to assess the effect of migalastat on FD cardiac involvement, combining LV morphology and tissue characterisation by cardiac magnetic resonance (CMR) with cardiopulmonary exercise testing (CPET). Methods: Sixteen treatment-naïve patients with FD (4 women, 46.4±16.2 years) with cardiac involvement (reduced T1 values on CMR and/or LV hypertrophy) underwent ECG, echocardiogram, troponin T and NT-proBNP (N-Terminal prohormone of Brain Natriuretic Peptide) assay, CMR with T1 mapping, and CPET before and after 18 months of migalastat. Results: No change in LV mass was detected at 18 months compared to baseline (95.2 g/m2 (66.0-184.0) vs 99.0 g/m2 (69.0-121.0), p=0.55). Overall, there was an increase in septal T1 of borderline significance (870.0 ms (848-882) vs 860.0 ms (833.0-875.0), p=0.056). Functional capacity showed an increase in oxygen consumption (VO2) at anaerobic threshold (15.50 mL/kg/min (13.70-21.50) vs 14.50 mL/kg/min (11.70-18.95), p=0.02), and a trend towards an increase in percent predicted peak VO2 (72.0 (63.0-80.0) vs 69.0 (53.0-77.0), p=0.056) was observed. The subset of patients who showed an increase in T1 value and a reduction in LV mass (n=7, 1 female, age 40.5 (28.6-76.0)) was younger and at an earlier disease stage compared to the others, and also exhibited greater improvement in exercise tolerance. Conclusion: In treatment-naïve FD patients with cardiac involvement, 18-month treatment with migalastat stabilised LV mass and was associated with a trend towards an improvement in exercise tolerance. A tendency to T1 increase was detected by CMR. The subset of patients who had significant benefits from the treatment showed an earlier cardiac disease compared to the others. Trial registration number: NCT03838237.
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- 2023
15. Continental Diversity of Chenopodium album Seedling Recruitment
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Andujar, G., J., Benoit, D. L., Davis, A., Dekker, J., Graziani, F., Grundy, A., Karlsson, L., Mead, A., Milberg, P., Neve, P., Rasmussen, I. A., Salonen, J., Sera, B., Sousa, E., Tei, F., Torresen, K. S., and Urbano, J. M.
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Quantitative Biology - Populations and Evolution - Abstract
Chenopodium album seedling emergence studies were conducted at nine European and two North American locations comparing local populations with a common population from Denmark. It is hypothesized that C. album seedling recruitment timing and magnitude have adapted to environmental and cropping system practices of a locality. Limitations in the habitat (filter 1) were reflected in local C. album population recruitment season length. Generally, the duration of seedling recruitment of both populations (local; DEN-COM) increased with decreasing latitude, north-to-south. In general, compared to the local population, DEN-COM recruitment at locations north of Denmark was longer and south of Denmark was shorter, and ended sooner. Generally, the local cropping system disturbances (CSD) period increased with decreasing latitude. The total duration of the CSD period was over twice as long in the south as that in the north. Recruitment at each locality possessed seasonal structure (time, number) consisting of 2-4 discrete seasonal cohorts. This may be an adaptive means by which C. album searches for, and exploits, recruitment opportunity just prior to, and after, predictable disturbances. The control of C. album seedling emergence is contained in the heteroblastic traits of its locally adapted seeds, and is stimulated by a complex interaction of light, heat, water, nitrate and oxygen signals inherent in the local environment. Our observations of complex recruitment patterns occurring at critical cropping times is strong evidence that C. album possesses a flexible and sensitive germination regulation system adaptable to opportunity in many different Eurasian and North American agricultural habitats., Comment: 82 pages; 12 tables; 20 seedling recruitment calendars; 9 data summaries; this manuscript is the product of the germination and seedling emergence working group of the European Weed Research Society
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- 2013
16. Molecular Dynamics Simulations of Temperature Equilibration in Dense Hydrogen
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Glosli, J. N., Graziani, F. R., More, R. M., Murillo, M. S., Streitz, F. H., Surh, M. P., Benedict, L. X., Hau-Riege, S., Langdon, A. B., and London, R. A.
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Physics - Plasma Physics - Abstract
The temperature equilibration rate in dense hydrogen (for both T_{i}>T_{e} and T_i
1, a model by Gericke-Murillo-Schlanges (GMS) [Gericke et al., PRE 65, 036418 (2002)] based on a T-matrix method and the approach by Brown-Preston-Singleton [Brown et al., Phys. Rep. 410, 237 (2005)] agrees with the simulation data to within the error bars of the simulation. For smaller Coulomb logarithms, the GMS model is consistent with the simulation results. Landau-Spitzer models are consistent with the simulation data for L>4. - Published
- 2008
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17. Enhanced energy coupling for indirectly driven inertial confinement fusion
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Ping, Y., Smalyuk, V. A., Amendt, P., Tommasini, R., Field, J. E., Khan, S., Bennett, D., Dewald, E., Graziani, F., Johnson, S., Landen, O. L., MacPhee, A. G., Nikroo, A., Pino, J., Prisbrey, S., Ralph, J., Seugling, R., Strozzi, D., Tipton, R. E., Wang, Y. M., Loomis, E., Merritt, E., and Montgomery, D.
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- 2019
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18. First bromine doped cryogenic implosion at the National Ignition Facility
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Hayes, A. C., primary, Kyrala, G., additional, Gooden, M., additional, Wilhelmy, J. B., additional, Kot, L., additional, Volegov, P., additional, Wilde, C., additional, Haines, B., additional, Jungman, Gerard, additional, Rundberg, R. S., additional, Wilson, D. C., additional, Velsko, C., additional, Cassata, W., additional, Henry, E., additional, Yeamans, C., additional, Cerjan, C., additional, Ma, T., additional, Döppner, T., additional, Nikroo, A., additional, Hurricane, O., additional, Callahan, D., additional, Hinkel, D., additional, Schneider, D., additional, Bachmann, B., additional, Graziani, F., additional, Chen, K. C., additional, Kong, C., additional, Huang, H., additional, Crippen, J. W., additional, Ratledge, M., additional, Rice, N. G., additional, and Farrell, M. P., additional
- Published
- 2023
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19. Electrocardiogram analysis in Anderson-Fabry disease: a valuable tool for progressive phenotypic expression tracking
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Parisi, V., primary, Baldassarre, R., additional, Ferrara, V., additional, Ditaranto, R., additional, Barlocco, F., additional, Lillo, R., additional, Re, F., additional, Marchi, G., additional, Chiti, C., additional, Di Nicola, F., additional, Catalano, C., additional, Barile, L., additional, Schiavo, M. A., additional, Ponziani, A., additional, Saturi, G., additional, Caponetti, A. G., additional, Berardini, A., additional, Graziosi, M., additional, Pasquale, F., additional, Salamon, I., additional, Ferracin, M., additional, Nardi, E., additional, Capelli, I., additional, Girelli, D., additional, Gimeno Blanes, J. R., additional, Biffi, M., additional, Galiè, N., additional, Olivotto, I., additional, Graziani, F., additional, and Biagini, E., additional
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- 2023
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20. C43 RELATIONSHIP BETWEEN ECHOCARDIOGRAPHIC DATA AND CARDIOPULMONARY EXERCISE TEST PARAMETERS IN ADULT CONGENITAL HEART DISEASE PATIENTS: A RETROSPECTIVE CLINICAL STUDY
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Olimpieri, A, primary, Ferraro, F, additional, Gambardella, R, additional, Di Molfetta, A, additional, Grandinetti, M, additional, Lillo, R, additional, Graziani, F, additional, Delogu, A, additional, Bruno, P, additional, and Massetti, M, additional
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- 2023
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21. Global longitudinal strain for prediction of mortality in ST-segment elevation myocardial infarction and aortic stenosis patients: two sides of the same coin.
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RAVENNA, E., LOCOROTONDO, G., MANFREDONIA, L., DIANA, G., FILICE, M., GRAZIANI, F., LEONE, A. M., AURIGEMMA, C., ROMAGNOLI, E., BURZOTTA, F., TRANI, C., MASSETTI, M., LOMBARDO, A., and LANZA, G. A.
- Abstract
OBJECTIVE: Global longitudinal strain (GLS) predicts major adverse events in ST-segment elevation myocardial infarction (STEMI) and aortic stenosis (AS). Different cutoff values and different end-points have been proposed for prognostic stratification. We aimed to verify whether a single GLS cut-off value can be used to identify increased risk of all-cause death in STEMI and AS. PATIENTS AND METHODS: One-hundredseventeen successfully treated first STEMI (age 63.8±12.5 yrs, 70% men) and 64 AS (age 80.3±6.9 yrs, 44% men) patients, undergoing echocardiography before discharge and before AS treatment, respectively, were retrospectively analyzed. GLS was analyzed, together with pulmonary artery systolic pressure (PASP), Killip class and Genereux stage. End-point was all-cause death at 6-month follow-up. RESULTS: All-cause death occurred in 4 (3.4%) STEMI and 5 (7.8%) AS patients (p=ns). AS patients who died had GLS similar to died STEMI patients (9.7±2.1 vs. 11.3±1.7, p=ns). GLS cut-off =12% predicted death with 89% sensitivity and 70% specificity (AUC 0.84, p=0.001): STEMI and AS patients with GLS =12% had worse survival than STEMI and AS patients with GLS >12% (log-rank p=0.001). At multivariate Cox regression analysis, lower GLS values independently predicted death (HR 0.667, 95% CI 0.451-0.986, p=0.042), and the prediction model was improved when GLS was added to old age, significant comorbidities, PASP and Killip/Genereux stage (X2 6.691 vs. 1.364, p=0.010). CONCLUSIONS: Died patients with STEMI and AS show similar values of GLS. A unique cut-off value of GLS can reliably be used to stratify the risk of all-cause death at 6-month follow-up in both two clinical settings. [ABSTRACT FROM AUTHOR]
- Published
- 2023
22. Publisher's Note: “First graded metal pushered single shell capsule implosions on the National Ignition Facility” [Phys. Plasmas 29, 052707 (2022)]
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Dewald, E. L., primary, MacLaren, S. A., additional, Martinez, D. A., additional, Pino, J. E., additional, Tipton, R. E., additional, Ho, D. D.-M., additional, Young, C. V., additional, Horwood, C., additional, Khan, S. F., additional, Hartouni, E. P., additional, Rubery, M. S., additional, Millot, M., additional, Vazsonyi, A. R., additional, Vonhof, S., additional, Mellos, G., additional, Johnson, S., additional, Smalyuk, V. A., additional, Graziani, F., additional, Monzon, E. R., additional, Tommasini, R., additional, Alessi, D., additional, Ayers, S., additional, Hall, G. N., additional, Holder, J., additional, Kalantar, D., additional, MacKinnon, A. J., additional, Okui, J., additional, Prantil, M., additional, Di Nicola, J.-M., additional, Lanier, T., additional, Thomas, A., additional, Yang, S., additional, Xu, H. W., additional, Huang, H., additional, Bae, J., additional, Kong, C. W., additional, Rice, N., additional, Wang, Y. M., additional, Volegov, P., additional, Freeman, M. S., additional, and Wilde, C., additional
- Published
- 2023
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23. Imposing correct jellium response is key to predict the density response by orbital-free DFT
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(0000-0002-9725-9208) Moldabekov, Z., Shao, X., Pavanello, M., Vorberger, J., Graziani, F., Dornheim, T., (0000-0002-9725-9208) Moldabekov, Z., Shao, X., Pavanello, M., Vorberger, J., Graziani, F., and Dornheim, T.
- Abstract
Orbital-free density functional theory constitutes a computationally highly effective tool for modeling electronic structures of systems ranging from room-temperature materials to warm dense matter. Its accuracy critically depends on the employed kinetic energy (KE) density functional, which has to be supplied as an external input. In this work we consider several nonlocal and Laplacian-level KE functionals and use an external harmonic perturbation to compute the static density response at T=0 K in the linear and beyond-linear response regimes. We test for the satisfaction of exact conditions in the limit of uniform densities and for how approximate KE functionals reproduce the density response of realistic materials (e.g., Al and Si) against the Kohn-Sham DFT reference, which employs the exact KE. The results illustrate that several functionals violate exact conditions in the uniform electron gas (UEG) limit. We find a strong correlation between the accuracy of the KE functionals in the UEG limit and in the strongly inhomogeneous case. This empirically demonstrates the importance of imposing the limit of UEG response for uniform densities and validates the use of the Lindhard function in the formulation of kernels for nonlocal functionals. This conclusion is substantiated by additional calculations for bulk aluminum (Al) with a face-centered cubic (fcc) lattice and silicon (Si) with an fcc lattice, body-centered cubic (bcc) lattice, and semiconducting crystal diamond state. The analysis of fcc Al, and fcc as well as bcc Si data follows closely the conclusions drawn for the UEG, allowing us to extend our conclusions to realistic systems that are subject to density inhomogeneities induced by ions.
- Published
- 2023
24. Bound state breaking and the importance of thermal exchange-correlation effects in warm dense hydrogen
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(0000-0002-9725-9208) Moldabekov, Z., (0000-0002-4561-0158) Schwalbe, S., (0000-0003-0290-3628) Böhme, M., (0000-0001-5926-9192) Vorberger, J., Shao, X., Pavanello, M., Graziani, F., (0000-0001-7293-6615) Dornheim, T., (0000-0002-9725-9208) Moldabekov, Z., (0000-0002-4561-0158) Schwalbe, S., (0000-0003-0290-3628) Böhme, M., (0000-0001-5926-9192) Vorberger, J., Shao, X., Pavanello, M., Graziani, F., and (0000-0001-7293-6615) Dornheim, T.
- Abstract
Hydrogen at extreme temperatures and pressures is ubiquitous throughout our universe and naturally occurs in a variety of astrophysical objects. In addition, it is of key relevance for cutting-edge technological applications, with inertial confinement fusion research being a prime example. In the present work, we present exact \emph{ab initio} path integral Monte Carlo (PIMC) results for the electronic density of warm dense hydrogen along a line of constant degeneracy across a broad range of densities. Using the well-known concept of reduced density gradients, we develop a new framework to identify the breaking of bound states due to pressure ionization in bulk hydrogen. Moreover, we use our PIMC results as a reference to rigorously assess the accuracy of a variety of exchange--correlation (XC) functionals in density functional theory calculations for different density regions. Here a key finding is the importance of thermal XC effects for the accurate description of density gradients in high-energy density systems. Our exact PIMC test set is freely available online and can be used to guide the development of new methodologies for the simulation of warm dense matter and beyond.
- Published
- 2023
25. Electronic Density Response of Warm Dense Matter
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(0000-0001-7293-6615) Dornheim, T., (0000-0002-9725-9208) Moldabekov, Z., (0000-0003-4211-2484) Ramakrishna, K., Tolias, P., Baczewski, A. D., (0000-0002-6350-4180) Kraus, D., Preston, T. R., Chapman, D. A., (0000-0003-0290-3628) Böhme, M., Döppner, T., Graziani, F., Bonitz, M., (0000-0001-9162-262X) Cangi, A., (0000-0001-5926-9192) Vorberger, J., (0000-0001-7293-6615) Dornheim, T., (0000-0002-9725-9208) Moldabekov, Z., (0000-0003-4211-2484) Ramakrishna, K., Tolias, P., Baczewski, A. D., (0000-0002-6350-4180) Kraus, D., Preston, T. R., Chapman, D. A., (0000-0003-0290-3628) Böhme, M., Döppner, T., Graziani, F., Bonitz, M., (0000-0001-9162-262X) Cangi, A., and (0000-0001-5926-9192) Vorberger, J.
- Abstract
Matter at extreme temperatures and pressures -- commonly known as warm dense matter (WDM) in the literature -- is ubiquitous throughout our Universe and occurs in a number of astrophysical objects such as giant planet interiors and brown dwarfs. Moreover, WDM is very important for technological applications such as inertial confinement fusion, and is realized in the laboratory using different techniques. A particularly important property for the understanding of WDM is given by its electronic density response to an external perturbation. Such response properties are routinely probed in x-ray Thomson scattering (XRTS) experiments, and, in addition, are central for the theoretical description of WDM. In this work, we give an overview of a number of recent developments in this field. To this end, we summarize the relevant theoretical background, covering the regime of linear-response theory as well as nonlinear effects, the fully dynamic response and its static, time-independent limit, and the connection between density response properties and imaginary-time correlation functions (ITCF). In addition, we introduce the most important numerical simulation techniques including ab initio path integral Monte Carlo (PIMC) simulations and different thermal density functional theory (DFT) approaches. From a practical perspective, we present a variety of simulation results for different density response properties, covering the archetypal model of the uniform electron gas and realistic WDM systems such as hydrogen. Moreover, we show how the concept of ITCFs can be used to infer the temperature from XRTS measurements of arbitrarily complex systems without the need for any models or approximations. Finally, we outline a strategy for future developments based on the close interplay between simulations and experiments.
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- 2023
26. Development of a new quantum trajectory molecular dynamics framework
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Svensson, P., Campbell, T., Graziani, F., (0000-0002-9725-9208) Moldabekov, Z., Lyu, N., Richardson, S., Vinko, S. M., Gregori, G., Svensson, P., Campbell, T., Graziani, F., (0000-0002-9725-9208) Moldabekov, Z., Lyu, N., Richardson, S., Vinko, S. M., and Gregori, G.
- Abstract
An extension to the wave packet description of quantum plasmas is presented, where the wave packet can be elongated in arbitrary directions. A generalised Ewald summation is constructed for the wave packet models accounting for long-range Coulomb interactions and fermionic effects are approximated by purpose-built Pauli potentials, self-consistent with the wave packets used. We demonstrate its numerical implementation with good parallel support and close to linear scaling in particle number, used for comparisons with the more common wave packet employing isotropic states. Ground state and thermal properties are compared between the models with differences occurring primarily in the electronic subsystem. Especially, the electrical conductivity of dense hydrogen is investigated where a 15% increase in DC conductivity can be seen in our wave packet model compared to other models.
- Published
- 2023
27. Left atrial strain analysis improves left ventricular filling pressures non-invasive estimation in the acute phase of Takotsubo syndrome
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Iannaccone, G, Graziani, F, Del Buono, M, Camilli, M, Lillo, R, Caffè, A, Moroni, F, La Vecchia, G, Pedicino, D, Sanna, T, Trani, C, Lombardo, A, Lanza, G, Massetti, M, Crea, F, Montone, R, Iannaccone, Giulia, Graziani, Francesca, Del Buono, Marco Giuseppe, Camilli, Massimiliano, Lillo, Rosa, Caffè, Andrea, Moroni, Francesco, La Vecchia, Giulia, Pedicino, Daniela, Sanna, Tommaso, Trani, Carlo, Lombardo, Antonella, Lanza, Gaetano Antonio, Massetti, Massimo, Crea, Filippo, Montone, Rocco A, Iannaccone, G, Graziani, F, Del Buono, M, Camilli, M, Lillo, R, Caffè, A, Moroni, F, La Vecchia, G, Pedicino, D, Sanna, T, Trani, C, Lombardo, A, Lanza, G, Massetti, M, Crea, F, Montone, R, Iannaccone, Giulia, Graziani, Francesca, Del Buono, Marco Giuseppe, Camilli, Massimiliano, Lillo, Rosa, Caffè, Andrea, Moroni, Francesco, La Vecchia, Giulia, Pedicino, Daniela, Sanna, Tommaso, Trani, Carlo, Lombardo, Antonella, Lanza, Gaetano Antonio, Massetti, Massimo, Crea, Filippo, and Montone, Rocco A
- Abstract
Aims The aim of our study is to assess the ability of left atrial (LA) strain values to improve left ventricular and diastolic pressure (LVEDP) non-invasive estimation as compared with traditional echocardiographic indexes in the acute phase of Takotsubo syndrome (TTS) and to predict adverse in-hospital outcomes in this population. Methods and results Consecutive TTS patients were prospectively enrolled. Left ventricular and diastolic pressure was measured at the time of catheterization. Transthoracic echocardiography was performed within 48 h from hospital admission. In-hospital complications (acute heart failure, death from any cause, and life-threatening arrhythmias) were collected. A total of 62 patients were analysed (72.2 ± 10.1 years, female 80%) and in-hospital complications occurred in 25 (40.3%). Left ventricular and diastolic pressure mean value was 24.53 ± 7.92 mmHg. Left atrial reservoir and pump strain values presented higher correlation with LVEDP (r −0.859, P < 0.001 and r −0.848, P < 0.001, respectively) in comparison with E/e ′ ratio, left atrial volume index (LAVi), and tricuspid regurgitation (TR) peak velocity. In addition, at receiver-operating characteristic curve analysis, LA reservoir and pump strain resulted to be better predictors of LVEDP above the mean of our population [0.909 (95% CI 0.818-0.999, P < 0.001) and 0.889 (95% CI 0.789-0.988, P < 0.001)], respectively] as compared with E/e′ ratio, LAVi, and TR peak velocity. Finally, LA reservoir strain resulted to be an independent predictor of worse in-hospital outcomes, together with LVEDP and left ventricular ejection fraction (all P < 0.001). Conclusion In our study, lower LA reservoir and pump strain values were better predictors of LVEDP as compared with traditional echocardiographic indexes in the acute phase of TTS syndrome. Moreover, LA reservoir strain was an independent predict- or of adverse in-hospital outcomes.
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- 2023
28. Effect of Migalastat on cArdiac Involvement in FabRry Disease: MAIORA study
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Camporeale, Antonia, Bandera, F., Pieroni, M., Pieruzzi, F., Spada, Marina, Bersano, A., Econimo, L., Lanzillo, C., Rubino, M., Mignani, R., Motta, I., Olivotto, I., Tanini, I., Valaperta, R., Chow, K., Baroni, I., Boveri, S., Graziani, Francesca, Pica, S., Tondi, L., Guazzi, M., Lombardi, M., Camporeale A., Spada M., Graziani F. (ORCID:0000-0002-4520-5689), Camporeale, Antonia, Bandera, F., Pieroni, M., Pieruzzi, F., Spada, Marina, Bersano, A., Econimo, L., Lanzillo, C., Rubino, M., Mignani, R., Motta, I., Olivotto, I., Tanini, I., Valaperta, R., Chow, K., Baroni, I., Boveri, S., Graziani, Francesca, Pica, S., Tondi, L., Guazzi, M., Lombardi, M., Camporeale A., Spada M., and Graziani F. (ORCID:0000-0002-4520-5689)
- Abstract
Background: A small but significant reduction in left ventricular (LV) mass after 18 months of migalastat treatment has been reported in Fabry disease (FD). This study aimed to assess the effect of migalastat on FD cardiac involvement, combining LV morphology and tissue characterisation by cardiac magnetic resonance (CMR) with cardiopulmonary exercise testing (CPET). Methods: Sixteen treatment-naïve patients with FD (4 women, 46.4±16.2 years) with cardiac involvement (reduced T1 values on CMR and/or LV hypertrophy) underwent ECG, echocardiogram, troponin T and NT-proBNP (N-Terminal prohormone of Brain Natriuretic Peptide) assay, CMR with T1 mapping, and CPET before and after 18 months of migalastat. Results: No change in LV mass was detected at 18 months compared to baseline (95.2 g/m2 (66.0-184.0) vs 99.0 g/m2 (69.0-121.0), p=0.55). Overall, there was an increase in septal T1 of borderline significance (870.0 ms (848-882) vs 860.0 ms (833.0-875.0), p=0.056). Functional capacity showed an increase in oxygen consumption (VO2) at anaerobic threshold (15.50 mL/kg/min (13.70-21.50) vs 14.50 mL/kg/min (11.70-18.95), p=0.02), and a trend towards an increase in percent predicted peak VO2 (72.0 (63.0-80.0) vs 69.0 (53.0-77.0), p=0.056) was observed. The subset of patients who showed an increase in T1 value and a reduction in LV mass (n=7, 1 female, age 40.5 (28.6-76.0)) was younger and at an earlier disease stage compared to the others, and also exhibited greater improvement in exercise tolerance. Conclusion: In treatment-naïve FD patients with cardiac involvement, 18-month treatment with migalastat stabilised LV mass and was associated with a trend towards an improvement in exercise tolerance. A tendency to T1 increase was detected by CMR. The subset of patients who had significant benefits from the treatment showed an earlier cardiac disease compared to the others. Trial registration number: NCT03838237.
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- 2023
29. Inflammation across the spectrum of hypertrophic cardiac phenotypes
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Lillo, Rosa, Graziani, Francesca, Franceschi, Francesco, Iannaccone, Giulia, Massetti, Massimo, Olivotto, I, Crea, Filippo, Liuzzo, Giovanna, Lillo R, Graziani F (ORCID:0000-0002-4520-5689), Franceschi F (ORCID:0000-0001-6266-445X), Iannaccone G, Massetti M (ORCID:0000-0002-7100-8478), Crea F (ORCID:0000-0001-9404-8846), Liuzzo G. (ORCID:0000-0002-5714-0907), Lillo, Rosa, Graziani, Francesca, Franceschi, Francesco, Iannaccone, Giulia, Massetti, Massimo, Olivotto, I, Crea, Filippo, Liuzzo, Giovanna, Lillo R, Graziani F (ORCID:0000-0002-4520-5689), Franceschi F (ORCID:0000-0001-6266-445X), Iannaccone G, Massetti M (ORCID:0000-0002-7100-8478), Crea F (ORCID:0000-0001-9404-8846), and Liuzzo G. (ORCID:0000-0002-5714-0907)
- Abstract
The hypertrophic cardiomyopathy phenotype encompasses a heterogeneous spectrum of genetic and acquired diseases characterized by the presence of left ventricular hypertrophy in the absence of abnormal cardiac loading conditions. This "umbrella diagnosis" includes the "classic" hypertrophic cardiomyopathy (HCM), due to sarcomere protein gene mutations, and its phenocopies caused by intra- or extracellular deposits, such as Fabry disease (FD) and cardiac amyloidosis (CA). All these conditions share a wide phenotypic variability which results from the combination of genetic and environmental factors and whose pathogenic mediators are poorly understood so far. Accumulating evidence suggests that inflammation plays a critical role in a broad spectrum of cardiovascular conditions, including cardiomyopathies. Indeed, inflammation can trigger molecular pathways which contribute to cardiomyocyte hypertrophy and dysfunction, extracellular matrix accumulation, and microvascular dysfunction. Growing evidence suggests that systemic inflammation is a possible key pathophysiologic process potentially involved in the pathogenesis of cardiac disease progression, influencing the severity of the phenotype and clinical outcome, including heart failure. In this review, we summarize current knowledge regarding the prevalence, clinical significance, and potential therapeutic implications of inflammation in HCM and two of its most important phenocopies, FD and CA.
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- 2023
30. Right ventricular strain in Fabry disease: Prognostic implications
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Meucci, M. C., Lillo, Rosa, Mango, F., Lombardo, Antonella, Lanza, Gaetano Antonio, Parisi, V., Grandinetti, M., Massetti, Massimo, Ajmone Marsan, N., Crea, Filippo, Graziani, Francesca, Lillo R., Lombardo A. (ORCID:0000-0003-3162-1830), Lanza G. A. (ORCID:0000-0003-2187-6653), Massetti M. (ORCID:0000-0002-7100-8478), Crea F. (ORCID:0000-0001-9404-8846), Graziani F. (ORCID:0000-0002-4520-5689), Meucci, M. C., Lillo, Rosa, Mango, F., Lombardo, Antonella, Lanza, Gaetano Antonio, Parisi, V., Grandinetti, M., Massetti, Massimo, Ajmone Marsan, N., Crea, Filippo, Graziani, Francesca, Lillo R., Lombardo A. (ORCID:0000-0003-3162-1830), Lanza G. A. (ORCID:0000-0003-2187-6653), Massetti M. (ORCID:0000-0002-7100-8478), Crea F. (ORCID:0000-0001-9404-8846), and Graziani F. (ORCID:0000-0002-4520-5689)
- Abstract
Introduction: Left ventricular (LV) hypertrophy is the main feature of cardiac involvement in Anderson-Fabry disease (FD), but the right ventricle (RV) is also frequently affected. Previous studies failed to demonstrate an independent association between conventional parameters of RV performance and outcomes in FD. Nevertheless, if RV free wall strain (RV-FWS), assessed by 2D speckle tracking analysis, may provide a better prognostication is currently unknown. Methods: We retrospectively evaluated the association between RV-FWS and the occurrence of cardiovascular events in a cohort of 56 patients with FD. The study endpoint comprises cardiovascular mortality, severe heart failure symptoms, new-onset atrial fibrillation and major arrhythmias requiring device implantation. Results: Reduced RV-FWS, defined by values lower than 23%, was found in 25 (45%) patients. During a median follow-up of 47 months, 16 (29%) patients met the study endpoint. A ROC-curve analysis confirmed the threshold of reduced RV-FWS (<23%) as the best cut-off for predicting cardiovascular events, but with a lower power compared to left-sided parameters. On univariable Cox regression analysis, RV-FWS, expressed as continuous variable, was significantly associated with the study endpoint (HR: 0.795, 95% CI: 0.710–0.889, p < 0.001). However, RV-FWS did not retain a significant association with outcomes, after adjustment for LV global longitudinal strain or indexed left atrial volume (p = 0.340 and p = 0.289 respectively). Conclusions: RV-FWS was not independently associated with the occurrence of cardiovascular events in FD, confirming previous observations that prognosis is mainly driven by the severity of LV cardiomyopathy.
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- 2023
31. Global longitudinal strain for prediction of mortality in ST-segment elevation myocardial infarction and aortic stenosis patients: two sides of the same coin
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Ravenna, E, Locorotondo, Gabriella, Manfredonia, L, Diana, G, Filice, M, Graziani, Francesca, Leone, Antonio Maria, Aurigemma, Cristina, Romagnoli, E, Burzotta, Francesco, Trani, Carlo, Massetti, Massimo, Lombardo, Antonella, Lanza, Gaetano Antonio, Locorotondo, G, Graziani, F (ORCID:0000-0002-4520-5689), Leone, A M (ORCID:0000-0002-1276-9883), Aurigemma, C, Burzotta, F (ORCID:0000-0002-6569-9401), Trani, C (ORCID:0000-0001-9777-013X), Massetti, M (ORCID:0000-0002-7100-8478), Lombardo, A (ORCID:0000-0003-3162-1830), Lanza, G A (ORCID:0000-0003-2187-6653), Ravenna, E, Locorotondo, Gabriella, Manfredonia, L, Diana, G, Filice, M, Graziani, Francesca, Leone, Antonio Maria, Aurigemma, Cristina, Romagnoli, E, Burzotta, Francesco, Trani, Carlo, Massetti, Massimo, Lombardo, Antonella, Lanza, Gaetano Antonio, Locorotondo, G, Graziani, F (ORCID:0000-0002-4520-5689), Leone, A M (ORCID:0000-0002-1276-9883), Aurigemma, C, Burzotta, F (ORCID:0000-0002-6569-9401), Trani, C (ORCID:0000-0001-9777-013X), Massetti, M (ORCID:0000-0002-7100-8478), Lombardo, A (ORCID:0000-0003-3162-1830), and Lanza, G A (ORCID:0000-0003-2187-6653)
- Abstract
Objective: Global longitudinal strain (GLS) predicts major adverse events in ST-segment elevation myocardial infarction (STEMI) and aortic stenosis (AS). Different cut-off values and different end-points have been proposed for prognostic stratification. We aimed to verify whether a single GLS cut-off value can be used to identify increased risk of all-cause death in STEMI and AS.Patients and methods: One-hundred- seventeen successfully treated first STEMI (age 63.8 +/- 12.5 yrs, 70% men) and 64 AS (age 80.3 +/- 6.9 yrs, 44% men) patients, undergoing echocardiography before discharge and before AS treatment, respectively, were retrospectively analyzed. GLS was analyzed, together with pulmonary artery systolic pressure (PASP), Killip class and Genereux stage. End-point was all-cause death at 6-month follow-up.Results: All-cause death occurred in 4 (3.4%) STEMI and 5 (7.8%) AS patients (p=ns). AS patients who died had GLS similar to died STEMI patients (9.7 +/- 2.1 vs. 11.3 +/- 1.7, p=ns). GLS cut-off <= 12% predicted death with 89% sensitivity and 70% specificity (AUC 0.84, p=0.001): STEMI and AS patients with GLS <= 12% had worse survival than STEMI and AS patients with GLS >12% (log-rank p=0.001). At multivariate Cox regression analysis, lower GLS values independently predicted death (HR 0.667, 95% CI 0.451-0.986, p=0.042), and the prediction model was improved when GLS was added to old age, significant comorbidities, PASP and Killip/Genereux stage (chi 2 6.691 vs. 1.364, p=0.010).Conclusions: Died patients with STEMI and AS show similar values of GLS. A unique cut-off value of GLS can reliably be used to stratify the risk of all-cause death at 6-month follow-up in both two clinical settings.
- Published
- 2023
32. Conservative surgical management of patients with bisphosphonate-related osteonecrosis of the jaws: a series of 120 patients
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Nisi, M., La Ferla, F., Karapetsa, D., Gennai, S., Ramaglia, L., Graziani, F., and Gabriele, M.
- Published
- 2016
- Full Text
- View/download PDF
33. Quantum computing for fusion energy science applications
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Joseph, I., primary, Shi, Y., additional, Porter, M. D., additional, Castelli, A. R., additional, Geyko, V. I., additional, Graziani, F. R., additional, Libby, S. B., additional, and DuBois, J. L., additional
- Published
- 2023
- Full Text
- View/download PDF
34. Risk factors influencing BRONJ staging in patients receiving intravenous bisphosphonates: a multivariate analysis
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Nisi, M., La Ferla, F., Karapetsa, D., Gennai, S., Miccoli, M., Baggiani, A., Graziani, F., and Gabriele, M.
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- 2015
- Full Text
- View/download PDF
35. Development of a new quantum trajectory molecular dynamics framework
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Svensson, P, Campbell, T, Graziani, F, Moldabekov, Z, Lyu, N, Richardson, S, Vinko, SAM, and Gregori, G
- Subjects
warm dense matter ,wave packet molecular dynamics ,Pauli potential - Abstract
An extension to the wave packet description of quantum plasmas is presented, where the wave packet can be elongated in arbitrary directions. A generalised Ewald summation is constructed for the wave packet models accounting for long-range Coulomb interactions and fermionic effects are approximated by purpose-built Pauli potentials, self-consistent with the wave packets used. We demonstrate its numerical implementation with good parallel support and close to linear scaling in particle number, used for comparisons with the more common wave packet employing isotropic states. Ground state and thermal properties are compared between the models with differences occurring primarily in the electronic subsystem. Especially, the electrical conductivity of dense hydrogen is investigated where a 15% increase in DC conductivity can be seen in our wave packet model compared to other models.
- Published
- 2023
36. ECG as a storytelling of cardiac involvement evolution in Anderson Fabry disease
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Chiti, C, primary, Ditaranto, R, additional, Barlocco, F, additional, Lillo, R, additional, Re, F, additional, Marchi, G, additional, Parisi, V, additional, Ferrara, V, additional, Baldassarre, R, additional, Di Nicola, F, additional, Gimeno Blanes, J R, additional, Graziani, F, additional, Galie', N, additional, Olivotto, I, additional, and Biagini, E, additional
- Published
- 2022
- Full Text
- View/download PDF
37. Electrocardiographic evolution in Anderson-Fabry disease patients on and off specific therapy: a potential marker to study the therapeutic cardiac goal
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Baldassarre, R, primary, Ditaranto, R, additional, Barlocco, F, additional, Lillo, R, additional, Re, F, additional, Marchi, G, additional, Parisi, V, additional, Ferrrara, V, additional, Di Nicola, F, additional, Chiti, C, additional, Gimeno Blanes, J R, additional, Graziani, F, additional, Galie', N, additional, Zancarano, A, additional, and Biagini, E, additional
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- 2022
- Full Text
- View/download PDF
38. Left atrial strain analysis improves non-invasive estimation of left ventricular filling pressures in takotsubo syndrome
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Iannaccone, G, primary, Graziani, F, additional, Del Buono, M G, additional, Camilli, M, additional, Lillo, R, additional, Caffe', A, additional, La Vecchia, G, additional, Rinaldi, R, additional, Pedicino, D, additional, Sanna, T, additional, Trani, C, additional, Lombardo, A, additional, Lanza, G A, additional, Montone, R A, additional, and Crea, F, additional
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- 2022
- Full Text
- View/download PDF
39. Electrocardiographic findings in Anderson-Fabry patients on disease specific therapy: can treatment prevent ECG changes?
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Di Nicola, F, primary, Ditaranto, R, additional, Barlocco, F, additional, Lillo, R, additional, Re, F, additional, Marchi, G, additional, Baldassarre, R, additional, Parisi, V, additional, Ferrara, V, additional, Chiti, C, additional, Gimeno Blanes, J R, additional, Graziani, F, additional, Galie', N, additional, Olivotto, I, additional, and Biagini, E, additional
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- 2022
- Full Text
- View/download PDF
40. Telemedicine for adult congenital heart disease patients during the first wave of COVID-19 era: a single center experience
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Grandinetti, M., Di Molfetta, A., Graziani, F., Delogu, A. B., Lillo, R., Perri, G., Pavone, N., Bruno, P., Aspromonte, N., Amodeo, A., Crea, F., Massetti, M., Di Molfetta A., Graziani F. (ORCID:0000-0002-4520-5689), Delogu A. B. (ORCID:0000-0002-2283-3180), Lillo R., Perri G., Pavone N., Bruno P. (ORCID:0000-0002-1075-5808), Aspromonte N., Crea F. (ORCID:0000-0001-9404-8846), Massetti M. (ORCID:0000-0002-7100-8478), Grandinetti, M., Di Molfetta, A., Graziani, F., Delogu, A. B., Lillo, R., Perri, G., Pavone, N., Bruno, P., Aspromonte, N., Amodeo, A., Crea, F., Massetti, M., Di Molfetta A., Graziani F. (ORCID:0000-0002-4520-5689), Delogu A. B. (ORCID:0000-0002-2283-3180), Lillo R., Perri G., Pavone N., Bruno P. (ORCID:0000-0002-1075-5808), Aspromonte N., Crea F. (ORCID:0000-0001-9404-8846), and Massetti M. (ORCID:0000-0002-7100-8478)
- Abstract
AIM: To summarize our experience on the implementation of a telemedicine service dedicated to adult congenital heart disease (ACHD) patients during the lockdown for the first wave of Coronavirus disease 2019 (COVID-19). METHODS: This is a prospective study enrolling all ACHD patients who answered a questionnaire dedicated telematic cardiovascular examination. RESULTS: A total of 289 patients were enrolled, 133 (47%) were male, 25 (9%) were affected by a genetic syndrome. The median age was 38 (29-51) years, whereas the median time interval between the last visit and the telematic follow-up was 9.5 (7.5-11.5) months. Overall, 35 patients (12%) reported a worsening of fatigue in daily life activity, 17 (6%) experienced chest pain, 42 (15%) had presyncope and 2 (1%) syncope; in addition, 28 patients (10%) presented peripheral edema and 14 (5%) were orthopneic. A total of 116 (40%) patients reported palpitations and 12 had at least one episode of atrial fibrillation and underwent successful electrical (8) or pharmacological (4) cardioversion. One patient was admitted to the emergency department for uncontrolled arterial hypertension, five for chest pain, and one for heart failure. Two patients presented fever but both had negative COVID-19 nasal swab. CONCLUSION: During the COVID-19 pandemic, the use of telemedicine dramatically increased and here we report a positive experience in ACHD patients. The postpandemic role of telemedicine will depend on permanent regulatory solutions and this early study might encourage a more systematic telematic approach for ACHD patients.
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- 2021
41. ECG-based score estimates the probability to detect Fabry Disease cardiac involvement
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Figliozzi, S, Camporeale, A, Boveri, S, Pieruzzi, F, Pieroni, M, Lusardi, P, Spada, M, Mignani, R, Burlina, A, Graziani, F, Pica, S, Tondi, L, Bernardini, A, Chow, K, Namdar, M, Lombardi, M, Figliozzi S., Camporeale A., Boveri S., Pieruzzi F., Pieroni M., Lusardi P., Spada M., Mignani R., Burlina A., Graziani F., Pica S., Tondi L., Bernardini A., Chow K., Namdar M., Lombardi M., Figliozzi, S, Camporeale, A, Boveri, S, Pieruzzi, F, Pieroni, M, Lusardi, P, Spada, M, Mignani, R, Burlina, A, Graziani, F, Pica, S, Tondi, L, Bernardini, A, Chow, K, Namdar, M, Lombardi, M, Figliozzi S., Camporeale A., Boveri S., Pieruzzi F., Pieroni M., Lusardi P., Spada M., Mignani R., Burlina A., Graziani F., Pica S., Tondi L., Bernardini A., Chow K., Namdar M., and Lombardi M.
- Abstract
Objectives: To elaborate an ECG-based nomogram estimating the probability to detect cardiac involvement by cardiac magnetic resonance (CMR) in Fabry Disease (FD). Methods: 119 FD patients and 26 healthy controls underwent ECG and CMR. Test (n = 88, 60%) and validation cohorts (n = 57, 40%) were randomly derived. Cardiac involvement was defined as the presence of low myocardial T1 value, a CMR-surrogate of myocardial glycosphingolipid storage. ECG changes associated with low T1 value were identified in the test cohort, included in the nomogram and then tested in the validation cohort. Results: Sokolow-Lyon index (AUC = 0.769), ratio between P-wave and PR-segment durations (Pwave/PRsegment) (AUC = 0.778), QRS duration (AUC = 0.703), QT (AUC = 0.769) duration were independently associated with the presence of low T1 on CMR at multivariate analysis. An ECG-based nomogram including these four parameters was accurate in identifying patients with CMR evidence of glycosphingolipid storage (c-index of the derived-nomogram = 0.90 in the test group; 0.81 in the validation group). Conclusion: We propose a practical ECG-based nomogram accurately estimating the probability to detect low T1 values by CMR in FD patients. The application of this tool in clinical practice could improve early detection of FD cardiac involvement.
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- 2021
42. An uplifted destiny for mucopolysaccharidosis type I with heart involvement
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Manna, R, Graziani, F, Lillo, R, Verrecchia, E, Sicignano, Ll, Rigante, D, Manna R (ORCID:0000-0003-1560-3907), Graziani F (ORCID:0000-0002-4520-5689), Verrecchia E, Sicignano LL, Rigante D (ORCID:0000-0001-7032-7779), Manna, R, Graziani, F, Lillo, R, Verrecchia, E, Sicignano, Ll, Rigante, D, Manna R (ORCID:0000-0003-1560-3907), Graziani F (ORCID:0000-0002-4520-5689), Verrecchia E, Sicignano LL, and Rigante D (ORCID:0000-0001-7032-7779)
- Abstract
We present a 63-year-old man with Hurler–Scheie syndrome,who underwent cardia surgery, being one of the long-lived patients ever reported.
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- 2021
43. The Prompt Spectrum of a Radiating Sphere: Benchmark Solutions for Diffusion and Transport
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Graziani, F., Barth, Timothy J., editor, Griebel, Michael, editor, Keyes, David E., editor, Nieminen, Risto M., editor, Roose, Dirk, editor, Schlick, Tamar, editor, and Graziani, Frank, editor
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- 2008
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44. A Practical Global Sensitivity Analysis Methodology for Multi-Physics Applications
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Tong, C., Graziani, F., Barth, Timothy J., editor, Griebel, Michael, editor, Keyes, David E., editor, Nieminen, Risto M., editor, Roose, Dirk, editor, Schlick, Tamar, editor, and Graziani, Frank, editor
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- 2008
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45. First graded metal pushered single shell capsule implosions on the National Ignition Facility
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Dewald, E. L., primary, MacLaren, S. A., additional, Martinez, D. A., additional, Pino, J. E., additional, Tipton, R. E., additional, Ho, D. D.-M., additional, Young, C. V., additional, Horwood, C., additional, Khan, S. F., additional, Hartouni, E. P., additional, Rubery, M. S., additional, Millot, M., additional, Vazsonyi, A. R., additional, Vonhof, S., additional, Mellos, G., additional, Johnson, S., additional, Smalyuk, V. A., additional, Graziani, F., additional, Monzon, E. R., additional, Xu, H. W., additional, Huang, H., additional, Bae, J., additional, Kong, C. W., additional, Rice, N., additional, Wang, Y. M., additional, Volegov, P., additional, Freeman, M. S., additional, and Wilde, C., additional
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- 2022
- Full Text
- View/download PDF
46. Atrial Dysfunction Assessed by Cardiac Magnetic Resonance as an Early Marker of Fabry Cardiomyopathy
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Bernardini, A, Camporeale, A, Pieroni, M, Pieruzzi, F, Figliozzi, S, Lusardi, P, Spada, M, Mignani, R, Burlina, A, Carubbi, F, Battaglia, Y, Graziani, F, Pica, S, Tondi, L, Chow, K, Boveri, S, Olivotto, I, Lombardi, M, Bernardini A., Camporeale A., Pieroni M., Pieruzzi F., Figliozzi S., Lusardi P., Spada M., Mignani R., Burlina A., Carubbi F., Battaglia Y., Graziani F., Pica S., Tondi L., Chow K., Boveri S., Olivotto I., Lombardi M., Bernardini, A, Camporeale, A, Pieroni, M, Pieruzzi, F, Figliozzi, S, Lusardi, P, Spada, M, Mignani, R, Burlina, A, Carubbi, F, Battaglia, Y, Graziani, F, Pica, S, Tondi, L, Chow, K, Boveri, S, Olivotto, I, Lombardi, M, Bernardini A., Camporeale A., Pieroni M., Pieruzzi F., Figliozzi S., Lusardi P., Spada M., Mignani R., Burlina A., Carubbi F., Battaglia Y., Graziani F., Pica S., Tondi L., Chow K., Boveri S., Olivotto I., and Lombardi M.
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- 2020
47. Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment
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Abu-Shawareb, H, Acree, R, Adams, P, Adams, J, Addis, B, Aden, R, Adrian, P, Afeyan, BB, Aggleton, M, Aghaian, L, Aguirre, A, Aikens, D, Akre, J, Albert, F, Albrecht, M, Albright, BJ, Albritton, J, Alcala, J, Alday, C, Alessi, DA, Alexander, N, Alfonso, J, Alfonso, N, Alger, E, Ali, SJ, Ali, ZA, Alley, WE, Amala, P, Amendt, PA, Amick, P, Ammula, S, Amorin, C, Ampleford, DJ, Anderson, RW, Anklam, T, Antipa, N, Appelbe, B, Aracne-Ruddle, C, Araya, E, Arend, M, Arnold, P, Arnold, T, Asay, J, Atherton, LJ, Atkinson, D, Atkinson, R, Auerbach, JM, Austin, B, Auyang, L, Awwal, AS, Ayers, J, Ayers, S, Ayers, T, Azevedo, S, Bachmann, B, Back, CA, Bae, J, Bailey, DS, Bailey, J, Baisden, T, Baker, KL, Baldis, H, Barber, D, Barberis, M, Barker, D, Barnes, A, Barnes, CW, Barrios, MA, Barty, C, Bass, I, Batha, SH, Baxamusa, SH, Bazan, G, Beagle, JK, Beale, R, Beck, BR, Beck, JB, Bedzyk, M, Beeler, RG, Behrendt, W, Belk, L, Bell, P, Belyaev, M, Benage, JF, Bennett, G, Benedetti, LR, Benedict, LX, Berger, R, Bernat, T, Bernstein, LA, Berry, B, Bertolini, L, Besenbruch, G, Betcher, J, Bettenhausen, R, Betti, R, Bezzerides, B, Bhandarkar, SD, Bickel, R, Biener, J, Biesiada, T, Bigelow, K, Bigelow-Granillo, J, Bigman, V, Bionta, RM, Birge, NW, Bitter, M, Black, AC, Bleile, R, Bleuel, DL, Bliss, E, Blue, B, Boehly, T, Boehm, K, Boley, CD, Bonanno, R, Bond, EJ, Bond, T, Bonino, MJ, Borden, M, Bourgade, J-L, Bousquet, J, Bowers, J, Bowers, M, Boyd, R, Bozek, A, Bradley, DK, Bradley, KS, Bradley, PA, Bradley, L, Brannon, L, Brantley, PS, Braun, D, Braun, T, Brienza-Larsen, K, Briggs, TM, Britten, J, Brooks, ED, Browning, D, Bruhn, MW, Brunner, TA, Bruns, H, Brunton, G, Bryant, B, Buczek, T, Bude, J, Buitano, L, Burkhart, S, Burmark, J, Burnham, A, Burr, R, Busby, LE, Butlin, B, Cabeltis, R, Cable, M, Cabot, WH, Cagadas, B, Caggiano, J, Cahayag, R, Caldwell, SE, Calkins, S, Callahan, DA, Calleja-Aguirre, J, Camara, L, Camp, D, Campbell, EM, Campbell, JH, Carey, B, Carey, R, Carlisle, K, Carlson, L, Carman, L, Carmichael, J, Carpenter, A, Carr, C, Carrera, JA, Casavant, D, Casey, A, Casey, DT, Castillo, A, Castillo, E, Castor, JI, Castro, C, Caughey, W, Cavitt, R, Celeste, J, Celliers, PM, Cerjan, C, Chandler, G, Chang, B, Chang, C, Chang, J, Chang, L, Chapman, R, Chapman, T, Chase, L, Chen, H, Chen, K, Chen, L-Y, Cheng, B, Chittenden, J, Choate, C, Chou, J, Chrien, RE, Chrisp, M, Christensen, K, Christensen, M, Christopherson, AR, Chung, M, Church, JA, Clark, A, Clark, DS, Clark, K, Clark, R, Claus, L, Cline, B, Cline, JA, Cobble, JA, Cochrane, K, Cohen, B, Cohen, S, Collette, MR, Collins, G, Collins, LA, Collins, TJB, Conder, A, Conrad, B, Conyers, M, Cook, AW, Cook, D, Cook, R, Cooley, JC, Cooper, G, Cope, T, Copeland, SR, Coppari, F, Cortez, J, Cox, J, Crandall, DH, Crane, J, Craxton, RS, Cray, M, Crilly, A, Crippen, JW, Cross, D, Cuneo, M, Cuotts, G, Czajka, CE, Czechowicz, D, Daly, T, Danforth, P, Darbee, R, Darlington, B, Datte, P, Dauffy, L, Davalos, G, Davidovits, S, Davis, P, Davis, J, Dawson, S, Day, RD, Day, TH, Dayton, M, Deck, C, Decker, C, Deeney, C, DeFriend, KA, Deis, G, Delamater, ND, Delettrez, JA, Demaret, R, Demos, S, Dempsey, SM, Desjardin, R, Desjardins, T, Desjarlais, MP, Dewald, EL, DeYoreo, J, Diaz, S, Dimonte, G, Dittrich, TR, Divol, L, Dixit, SN, Dixon, J, Dodd, ES, Dolan, D, Donovan, A, Donovan, M, Döppner, T, Dorrer, C, Dorsano, N, Douglas, MR, Dow, D, Downie, J, Downing, E, Dozieres, M, Draggoo, V, Drake, D, Drake, RP, Drake, T, Dreifuerst, G, DuBois, DF, DuBois, PF, Dunham, G, Dylla-Spears, R, Dymoke-Bradshaw, AKL, Dzenitis, B, Ebbers, C, Eckart, M, Eddinger, S, Eder, D, Edgell, D, Edwards, MJ, Efthimion, P, Eggert, JH, Ehrlich, B, Ehrmann, P, Elhadj, S, Ellerbee, C, Elliott, NS, Ellison, CL, Elsner, F, Emerich, M, Engelhorn, K, England, T, English, E, Epperson, P, Epstein, R, Erbert, G, Erickson, MA, Erskine, DJ, Erlandson, A, Espinosa, RJ, Estes, C, Estabrook, KG, Evans, S, Fabyan, A, Fair, J, Fallejo, R, Farmer, N, Farmer, WA, Farrell, M, Fatherley, VE, Fedorov, M, Feigenbaum, E, Feit, M, Ferguson, W, Fernandez, JC, Fernandez-Panella, A, Fess, S, Field, JE, Filip, CV, Fincke, JR, Finn, T, Finnegan, SM, Finucane, RG, Fischer, M, Fisher, A, Fisher, J, Fishler, B, Fittinghoff, D, Fitzsimmons, P, Flegel, M, Flippo, KA, Florio, J, Folta, J, Folta, P, Foreman, LR, Forrest, C, Forsman, A, Fooks, J, Foord, M, Fortner, R, Fournier, K, Fratanduono, DE, Frazier, N, Frazier, T, Frederick, C, Freeman, MS, Frenje, J, Frey, D, Frieders, G, Friedrich, S, Froula, DH, Fry, J, Fuller, T, Gaffney, J, Gales, S, Le Galloudec, B, Le Galloudec, KK, Gambhir, A, Gao, L, Garbett, WJ, Garcia, A, Gates, C, Gaut, E, Gauthier, P, Gavin, Z, Gaylord, J, Geissel, M, Génin, F, Georgeson, J, Geppert-Kleinrath, H, Geppert-Kleinrath, V, Gharibyan, N, Gibson, J, Gibson, C, Giraldez, E, Glebov, V, Glendinning, SG, Glenn, S, Glenzer, SH, Goade, S, Gobby, PL, Goldman, SR, Golick, B, Gomez, M, Goncharov, V, Goodin, D, Grabowski, P, Grafil, E, Graham, P, Grandy, J, Grasz, E, Graziani, F, Greenman, G, Greenough, JA, Greenwood, A, Gregori, G, Green, T, Griego, JR, Grim, GP, Grondalski, J, Gross, S, Guckian, J, Guler, N, Gunney, B, Guss, G, Haan, S, Hackbarth, J, Hackel, L, Hackel, R, Haefner, C, Hagmann, C, Hahn, KD, Hahn, S, Haid, BJ, Haines, BM, Hall, BM, Hall, C, Hall, GN, Hamamoto, M, Hamel, S, Hamilton, CE, Hammel, BA, Hammer, JH, Hampton, G, Hamza, A, Handler, A, Hansen, S, Hanson, D, Haque, R, Harding, D, Harding, E, Hares, JD, Harris, DB, Harte, JA, Hartouni, EP, Hatarik, R, Hatchett, S, Hauer, AA, Havre, M, Hawley, R, Hayes, J, Hayes, S, Hayes-Sterbenz, A, Haynam, CA, Haynes, DA, Headley, D, Heal, A, Heebner, JE, Heerey, S, Heestand, GM, Heeter, R, Hein, N, Heinbockel, C, Hendricks, C, Henesian, M, Heninger, J, Henrikson, J, Henry, EA, Herbold, EB, Hermann, MR, Hermes, G, Hernandez, JE, Hernandez, VJ, Herrmann, MC, Herrmann, HW, Herrera, OD, Hewett, D, Hibbard, R, Hicks, DG, Hill, D, Hill, K, Hilsabeck, T, Hinkel, DE, Ho, DD, Ho, VK, Hoffer, JK, Hoffman, NM, Hohenberger, M, Hohensee, M, Hoke, W, Holdener, D, Holdener, F, Holder, JP, Holko, B, Holunga, D, Holzrichter, JF, Honig, J, Hoover, D, Hopkins, D, Berzak Hopkins, L, Hoppe, M, Hoppe, ML, Horner, J, Hornung, R, Horsfield, CJ, Horvath, J, Hotaling, D, House, R, Howell, L, Hsing, WW, Hu, SX, Huang, H, Huckins, J, Hui, H, Humbird, KD, Hund, J, Hunt, J, Hurricane, OA, Hutton, M, Huynh, KH-K, Inandan, L, Iglesias, C, Igumenshchev, IV, Izumi, N, Jackson, M, Jackson, J, Jacobs, SD, James, G, Jancaitis, K, Jarboe, J, Jarrott, LC, Jasion, D, Jaquez, J, Jeet, J, Jenei, AE, Jensen, J, Jimenez, J, Jimenez, R, Jobe, D, Johal, Z, Johns, HM, Johnson, D, Johnson, MA, Gatu Johnson, M, Johnson, RJ, Johnson, S, Johnson, SA, Johnson, T, Jones, K, Jones, O, Jones, M, Jorge, R, Jorgenson, HJ, Julian, M, Jun, BI, Jungquist, R, Kaae, J, Kabadi, N, Kaczala, D, Kalantar, D, Kangas, K, Karasiev, VV, Karasik, M, Karpenko, V, Kasarky, A, Kasper, K, Kauffman, R, Kaufman, MI, Keane, C, Keaty, L, Kegelmeyer, L, Keiter, PA, Kellett, PA, Kellogg, J, Kelly, JH, Kemic, S, Kemp, AJ, Kemp, GE, Kerbel, GD, Kershaw, D, Kerr, SM, Kessler, TJ, Key, MH, Khan, SF, Khater, H, Kiikka, C, Kilkenny, J, Kim, Y, Kim, Y-J, Kimko, J, Kimmel, M, Kindel, JM, King, J, Kirkwood, RK, Klaus, L, Klem, D, Kline, JL, Klingmann, J, Kluth, G, Knapp, P, Knauer, J, Knipping, J, Knudson, M, Kobs, D, Koch, J, Kohut, T, Kong, C, Koning, JM, Koning, P, Konior, S, Kornblum, H, Kot, LB, Kozioziemski, B, Kozlowski, M, Kozlowski, PM, Krammen, J, Krasheninnikova, NS, Kraus, B, Krauser, W, Kress, JD, Kritcher, AL, Krieger, E, Kroll, JJ, Kruer, WL, Kruse, MKG, Kucheyev, S, Kumbera, M, Kumpan, S, Kunimune, J, Kustowski, B, Kwan, TJT, Kyrala, GA, Laffite, S, Lafon, M, LaFortune, K, Lahmann, B, Lairson, B, Landen, OL, Langenbrunner, J, Lagin, L, Land, T, Lane, M, Laney, D, Langdon, AB, Langer, SH, Langro, A, Lanier, NE, Lanier, TE, Larson, D, Lasinski, BF, Lassle, D, LaTray, D, Lau, G, Lau, N, Laumann, C, Laurence, A, Laurence, TA, Lawson, J, Le, HP, Leach, RR, Leal, L, Leatherland, A, LeChien, K, Lechleiter, B, Lee, A, Lee, M, Lee, T, Leeper, RJ, Lefebvre, E, Leidinger, J-P, LeMire, B, Lemke, RW, Lemos, NC, Le Pape, S, Lerche, R, Lerner, S, Letts, S, Levedahl, K, Lewis, T, Li, CK, Li, H, Li, J, Liao, W, Liao, ZM, Liedahl, D, Liebman, J, Lindford, G, Lindman, EL, Lindl, JD, Loey, H, London, RA, Long, F, Loomis, EN, Lopez, FE, Lopez, H, Losbanos, E, Loucks, S, Lowe-Webb, R, Lundgren, E, Ludwigsen, AP, Luo, R, Lusk, J, Lyons, R, Ma, T, Macallop, Y, MacDonald, MJ, MacGowan, BJ, Mack, JM, Mackinnon, AJ, MacLaren, SA, MacPhee, AG, Magelssen, GR, Magoon, J, Malone, RM, Malsbury, T, Managan, R, Mancini, R, Manes, K, Maney, D, Manha, D, Mannion, OM, Manuel, AM, Mapoles, E, Mara, G, Marcotte, T, Marin, E, Marinak, MM, Mariscal, C, Mariscal, DA, Mariscal, EF, Marley, EV, Marozas, JA, Marquez, R, Marshall, CD, Marshall, FJ, Marshall, M, Marshall, S, Marticorena, J, Martinez, D, Maslennikov, I, Mason, D, Mason, RJ, Masse, L, Massey, W, Masson-Laborde, P-E, Masters, ND, Mathisen, D, Mathison, E, Matone, J, Matthews, MJ, Mattoon, C, Mattsson, TR, Matzen, K, Mauche, CW, Mauldin, M, McAbee, T, McBurney, M, Mccarville, T, McCrory, RL, McEvoy, AM, McGuffey, C, Mcinnis, M, McKenty, P, McKinley, MS, McLeod, JB, McPherson, A, Mcquillan, B, Meamber, M, Meaney, KD, Meezan, NB, Meissner, R, Mehlhorn, TA, Mehta, NC, Menapace, J, Merrill, FE, Merritt, BT, Merritt, EC, Meyerhofer, DD, Mezyk, S, Mich, RJ, Michel, PA, Milam, D, Miller, C, Miller, D, Miller, DS, Miller, E, Miller, EK, Miller, J, Miller, M, Miller, PE, Miller, T, Miller, W, Miller-Kamm, V, Millot, M, Milovich, JL, Minner, P, Miquel, J-L, Mitchell, S, Molvig, K, Montesanti, RC, Montgomery, DS, Monticelli, M, Montoya, A, Moody, JD, Moore, AS, Moore, E, Moran, M, Moreno, JC, Moreno, K, Morgan, BE, Morrow, T, Morton, JW, Moses, E, Moy, K, Muir, R, Murillo, MS, Murray, JE, Murray, JR, Munro, DH, Murphy, TJ, Munteanu, FM, Nafziger, J, Nagayama, T, Nagel, SR, Nast, R, Negres, RA, Nelson, A, Nelson, D, Nelson, J, Nelson, S, Nemethy, S, Neumayer, P, Newman, K, Newton, M, Nguyen, H, Di Nicola, J-MG, Di Nicola, P, Niemann, C, Nikroo, A, Nilson, PM, Nobile, A, Noorai, V, Nora, R, Norton, M, Nostrand, M, Note, V, Novell, S, Nowak, PF, Nunez, A, Nyholm, RA, O'Brien, M, Oceguera, A, Oertel, JA, Okui, J, Olejniczak, B, Oliveira, J, Olsen, P, Olson, B, Olson, K, Olson, RE, Opachich, YP, Orsi, N, Orth, CD, Owen, M, Padalino, S, Padilla, E, Paguio, R, Paguio, S, Paisner, J, Pajoom, S, Pak, A, Palaniyappan, S, Palma, K, Pannell, T, Papp, F, Paras, D, Parham, T, Park, H-S, Pasternak, A, Patankar, S, Patel, MV, Patel, PK, Patterson, R, Patterson, S, Paul, B, Paul, M, Pauli, E, Pearce, OT, Pearcy, J, Pedrotti, B, Peer, A, Pelz, LJ, Penetrante, B, Penner, J, Perez, A, Perkins, LJ, Pernice, E, Perry, TS, Person, S, Petersen, D, Petersen, T, Peterson, DL, Peterson, EB, Peterson, JE, Peterson, JL, Peterson, K, Peterson, RR, Petrasso, RD, Philippe, F, Phipps, TJ, Piceno, E, Ping, Y, Pickworth, L, Pino, J, Plummer, R, Pollack, GD, Pollaine, SM, Pollock, BB, Ponce, D, Ponce, J, Pontelandolfo, J, Porter, JL, Post, J, Poujade, O, Powell, C, Powell, H, Power, G, Pozulp, M, Prantil, M, Prasad, M, Pratuch, S, Price, S, Primdahl, K, Prisbrey, S, Procassini, R, Pruyne, A, Pudliner, B, Qiu, SR, Quan, K, Quinn, M, Quintenz, J, Radha, PB, Rainer, F, Ralph, JE, Raman, KS, Raman, R, Rambo, P, Rana, S, Randewich, A, Rardin, D, Ratledge, M, Ravelo, N, Ravizza, F, Rayce, M, Raymond, A, Raymond, B, Reed, B, Reed, C, Regan, S, Reichelt, B, Reis, V, Reisdorf, S, Rekow, V, Remington, BA, Rendon, A, Requieron, W, Rever, M, Reynolds, H, Reynolds, J, Rhodes, J, Rhodes, M, Richardson, MC, Rice, B, Rice, NG, Rieben, R, Rigatti, A, Riggs, S, Rinderknecht, HG, Ring, K, Riordan, B, Riquier, R, Rivers, C, Roberts, D, Roberts, V, Robertson, G, Robey, HF, Robles, J, Rocha, P, Rochau, G, Rodriguez, J, Rodriguez, S, Rosen, M, Rosenberg, M, Ross, G, Ross, JS, Ross, P, Rouse, J, Rovang, D, Rubenchik, AM, Rubery, MS, Ruiz, CL, Rushford, M, Russ, B, Rygg, JR, Ryujin, BS, Sacks, RA, Sacks, RF, Saito, K, Salmon, T, Salmonson, JD, Sanchez, J, Samuelson, S, Sanchez, M, Sangster, C, Saroyan, A, Sater, J, Satsangi, A, Sauers, S, Saunders, R, Sauppe, JP, Sawicki, R, Sayre, D, Scanlan, M, Schaffers, K, Schappert, GT, Schiaffino, S, Schlossberg, DJ, Schmidt, DW, Schmitt, MJ, Schneider, DHG, Schneider, MB, Schneider, R, Schoff, M, Schollmeier, M, Schölmerich, M, Schroeder, CR, Schrauth, SE, Scott, HA, Scott, I, Scott, JM, Scott, RHH, Scullard, CR, Sedillo, T, Seguin, FH, Seka, W, Senecal, J, Sepke, SM, Seppala, L, Sequoia, K, Severyn, J, Sevier, JM, Sewell, N, Seznec, S, Shah, RC, Shamlian, J, Shaughnessy, D, Shaw, M, Shaw, R, Shearer, C, Shelton, R, Shen, N, Sherlock, MW, Shestakov, AI, Shi, EL, Shin, SJ, Shingleton, N, Shmayda, W, Shor, M, Shoup, M, Shuldberg, C, Siegel, L, Silva, FJ, Simakov, AN, Sims, BT, Sinars, D, Singh, P, Sio, H, Skulina, K, Skupsky, S, Slutz, S, Sluyter, M, Smalyuk, VA, Smauley, D, Smeltser, RM, Smith, C, Smith, I, Smith, J, Smith, L, Smith, R, Sohn, R, Sommer, S, Sorce, C, Sorem, M, Soures, JM, Spaeth, ML, Spears, BK, Speas, S, Speck, D, Speck, R, Spears, J, Spinka, T, Springer, PT, Stadermann, M, Stahl, B, Stahoviak, J, Stanton, LG, Steele, R, Steele, W, Steinman, D, Stemke, R, Stephens, R, Sterbenz, S, Sterne, P, Stevens, D, Stevers, J, Still, CB, Stoeckl, C, Stoeffl, W, Stolken, JS, Stolz, C, Storm, E, Stone, G, Stoupin, S, Stout, E, Stowers, I, Strauser, R, Streckart, H, Streit, J, Strozzi, DJ, Suratwala, T, Sutcliffe, G, Suter, LJ, Sutton, SB, Svidzinski, V, Swadling, G, Sweet, W, Szoke, A, Tabak, M, Takagi, M, Tambazidis, A, Tang, V, Taranowski, M, Taylor, LA, Telford, S, Theobald, W, Thi, M, Thomas, A, Thomas, CA, Thomas, I, Thomas, R, Thompson, IJ, Thongstisubskul, A, Thorsness, CB, Tietbohl, G, Tipton, RE, Tobin, M, Tomlin, N, Tommasini, R, Toreja, AJ, Torres, J, Town, RPJ, Townsend, S, Trenholme, J, Trivelpiece, A, Trosseille, C, Truax, H, Trummer, D, Trummer, S, Truong, T, Tubbs, D, Tubman, ER, Tunnell, T, Turnbull, D, Turner, RE, Ulitsky, M, Upadhye, R, Vaher, JL, VanArsdall, P, VanBlarcom, D, Vandenboomgaerde, M, VanQuinlan, R, Van Wonterghem, BM, Varnum, WS, Velikovich, AL, Vella, A, Verdon, CP, Vermillion, B, Vernon, S, Vesey, R, Vickers, J, Vignes, RM, Visosky, M, Vocke, J, Volegov, PL, Vonhof, S, Von Rotz, R, Vu, HX, Vu, M, Wall, D, Wall, J, Wallace, R, Wallin, B, Walmer, D, Walsh, CA, Walters, CF, Waltz, C, Wan, A, Wang, A, Wang, Y, Wark, JS, Warner, BE, Watson, J, Watt, RG, Watts, P, Weaver, J, Weaver, RP, Weaver, S, Weber, CR, Weber, P, Weber, SV, Wegner, P, Welday, B, Welser-Sherrill, L, Weiss, K, Widmann, K, Wheeler, GF, Whistler, W, White, RK, Whitley, HD, Whitman, P, Wickett, ME, Widmayer, C, Wiedwald, J, Wilcox, R, Wilcox, S, Wild, C, Wilde, BH, Wilde, CH, Wilhelmsen, K, Wilke, MD, Wilkens, H, Wilkins, P, Wilks, SC, Williams, EA, Williams, GJ, Williams, W, Williams, WH, Wilson, DC, Wilson, B, Wilson, E, Wilson, R, Winters, S, Wisoff, J, Wittman, M, Wolfe, J, Wong, A, Wong, KW, Wong, L, Wong, N, Wood, R, Woodhouse, D, Woodruff, J, Woods, DT, Woods, S, Woodworth, BN, Wooten, E, Wootton, A, Work, K, Workman, JB, Wright, J, Wu, M, Wuest, C, Wysocki, FJ, Xu, H, Yamaguchi, M, Yang, B, Yang, ST, Yatabe, J, Yeamans, CB, Yee, BC, Yi, SA, Yin, L, Young, B, Young, CS, Young, CV, Young, P, Youngblood, K, Zacharias, R, Zagaris, G, Zaitseva, N, Zaka, F, Ze, F, Zeiger, B, Zika, M, Zimmerman, GB, Zobrist, T, Zuegel, JD, Zylstra, AB, Indirect Drive ICF Collaboration, Collaboration, Indirect Drive ICF, AWE Plc, Lawrence Livermore National Laboratory, and U.S Department of Energy
- Subjects
General Physics ,02 Physical Sciences ,General Physics and Astronomy ,Indirect Drive ICF Collaboration ,01 Mathematical Sciences ,09 Engineering - Abstract
For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion.
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- 2022
48. Towards a quantum fluid theory of correlated many-fermion systems from first principles
- Author
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Moldabekov, Zh. A., Dornheim, T., Gregori, G., Graziani, F., Bonitz, M., and Cangi, A.
- Subjects
Plasma Physics (physics.plasm-ph) ,Condensed Matter - Strongly Correlated Electrons ,warm dense matter ,Strongly Correlated Electrons (cond-mat.str-el) ,Quantum Gases (cond-mat.quant-gas) ,Condensed Matter Physics - Computational ,Physics ,QC1-999 ,Nuclear Theory ,FOS: Physical sciences ,General Physics and Astronomy ,Condensed Matter - Quantum Gases ,Physics - Plasma Physics - Abstract
Correlated many-fermion systems emerge in a broad range of phenomena in warm dense matter, plasmonics, and ultracold atoms. Quantum hydrodynamics (QHD) complements first-principles methods for many-fermion systems at larger scales. We illustrate the failure of the standard Bohm potential central to QHD for strong perturbations when the density perturbation is larger than about 10^{-3}10−3 of the mean density. We then extend QHD to this regime via the many-fermion Bohm potential from first-principles. This may lead to more accurate QHD simulations beyond their common application domain in the presence of strong perturbations at scales unattainable with first-principles methods.
- Published
- 2022
49. Development of a new quantum trajectory molecular dynamics framework
- Author
-
Svensson, P., Campbell, T., Graziani, F., (0000-0002-9725-9208) Moldabekov, Z., Lyu, N., Richardson, S., Vinko, S. M., Gregori, G., Svensson, P., Campbell, T., Graziani, F., (0000-0002-9725-9208) Moldabekov, Z., Lyu, N., Richardson, S., Vinko, S. M., and Gregori, G.
- Abstract
An extension to the wave packet description of quantum plasmas is presented, where the wave packet can be elongated in arbitrary directions. A generalised Ewald summation is constructed for the wave packet models accounting for long-range Coulomb interactions and fermionic effects are approximated by purpose-built Pauli potentials, self-consistent with the wave packets used. We demonstrate its numerical implementation with good parallel support and close to linear scaling in particle number, used for comparisons with the more common wave packet employing isotropic states. Ground state and thermal properties are compared between the models with differences occurring primarily in the electronic subsystem. Especially, the electrical conductivity of dense hydrogen is investigated where a 15% increase in DC conductivity can be seen in our wave packet model compared to other models.
- Published
- 2022
50. Towards a Quantum Fluid Theory of Correlated Many-Fermion Systems from First Principles
- Author
-
(0000-0002-9725-9208) Moldabekov, Z., Dornheim, T., Gregori, G., Graziani, F., Bonitz, M., (0000-0001-9162-262X) Cangi, A., (0000-0002-9725-9208) Moldabekov, Z., Dornheim, T., Gregori, G., Graziani, F., Bonitz, M., and (0000-0001-9162-262X) Cangi, A.
- Abstract
Correlated many-fermion systems emerge in a broad range of phenomena in warm dense matter, plasmonics, and ultracold atoms. Quantum hydrodynamics (QHD) complements first-principles methods for many-fermion systems at larger scales. We illustrate the failure of the standard Bohm potential central to QHD for strong perturbations when the density perturbation is larger than about 10−3 of the mean density. We then extend QHD to this regime via the many-fermion Bohm potential from first-principles. This may lead to more accurate QHD simulations beyond their common application domain in the presence of strong perturbations at scales unattainable with first-principles methods.
- Published
- 2022
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