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6. Current practice and surgical outcomes of neoadjuvant chemotherapy for early breast cancer: UK NeST study

Author

Fatayer, Hiba, O'Connell, Rachel L, Bannon, Finian, Coles, Charlotte E, Copson, Ellen, Cutress, Ramsey I, Dave, Rajiv V, Gardiner, Matthew D, Grayson, Margaret, Holcombe, Christopher, Irshad, Sheeba, Irwin, Gareth W, O'Brien, Ciara, Palmieri, Carlo, Shaaban, Abeer M, Sharma, Nisha, Singh, Jagdeep K, Whitehead, Ian, Potter, Shelley, McIntosh, Stuart A, NeST Study Research Collaborative, O'Connell, Rachel L [0000-0001-5990-8142], Gardiner, Matthew D [0000-0002-8058-4186], Potter, Shelley [0000-0002-6977-312X], McIntosh, Stuart A [0000-0002-4123-9611], and Apollo - University of Cambridge Repository

Subjects
Treatment Outcome, SDG 3 - Good Health and Well-being, Chemotherapy, Adjuvant, Antineoplastic Combined Chemotherapy Protocols, Humans, Breast Neoplasms, Female, Surgery, skin and connective tissue diseases, Mastectomy, Segmental, Neoadjuvant Therapy, United Kingdom
Abstract

Neoadjuvant chemotherapy (NACT) is increasingly being used to treat early breast cancer, and offers several advantages, including reducing the extent of breast and axillary surgery, and providing an in vivo assessment of tumour sensitivity to treatment1–4. Clinical trials have identified tumour subgroups with high rates of pCR. A pCR can be achieved in 45–90 per cent of human epidermal growth factor receptor 2-positive (HER2+) tumours and triple-negative breast cancer (TNBC), but the rate in oestrogen receptor-positive (ER+)/HER2-negative (HER2–) breast cancer remains below 10 per cent3,5. Historically, increasing pCR rates following NACT have not translated into more breast-conserving surgery (BCS), but more recent data suggest that NACT can result in surgical downstaging6.NACT use in the UK appears inconsistent, as highlighted by a recent prospective audit7. Although UK guidelines suggest considering NACT in patients with HER2+ cancers and TNBC, detailed guidance does not exist8. Furthermore, it is unclear whether pCR rates in routine clinical practice reflect those observed in trials, and whether tumour downstaging influences surgical decision-making beyond the trial setting. Moreover, there remains a lack of consensus on whether definitive surgery should aim to excise the original or post-treatment tumour footprint, as highlighted in a recent UK survey9, in which 24 per cent of centres stated that their routine practice was to excise the original tumour footprint rather than carry out response-adapted surgery.This prospective study aimed to determine surgical decision-making in the breast and axilla and pCR rates in routine clinical practice following NACT for early breast cancer.

Published
2022

7. Delivering a research-enabled multistakeholder partnership for enhanced patient care at a population level: The Northern Ireland Comprehensive Cancer Program

Author

Lawler, Mark, Gavin, Anna, Salto-Tellez, Manuel, Kennedy, Richard D., Van Schaeybroeck, Sandra, Wilson, Richard H., Harkin, Denis Paul, Grayson, Margaret, Boyd, Ruth E., Hamilton, Peter W., McArt, Darragh G., James, Jacqueline, Robson, Tracy, Ladner, Robert D., Prise, Kevin M., OʼSullivan, Joe M., Harrison, Timothy, Murray, Liam, Johnston, Patrick G., and Waugh, David J.

Published
2016
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8. Additional file 1 of Early switch from intravenous to oral antibiotic therapy in patients with cancer who have low-risk neutropenic sepsis (the EASI-SWITCH trial): study protocol for a randomised controlled trial

Author

Forde, Caroline, McMullan, Ronan, Clarke, Mike, Wilson, Richard H., Plummer, Ruth, Grayson, Margaret, Cliona McDowell, Agus, Ashley, Annmarie Doran, McAuley, Danny F., Thomas, Anne L., Barnes, Rosemary A., Adams, Richard, Chau, Ian, and Coyle, Vicky

Abstract

Additional file 1. SPIRIT checklist.

Published
2020
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9. Additional file 2 of Early switch from intravenous to oral antibiotic therapy in patients with cancer who have low-risk neutropenic sepsis (the EASI-SWITCH trial): study protocol for a randomised controlled trial

Author

Forde, Caroline, McMullan, Ronan, Clarke, Mike, Wilson, Richard H., Plummer, Ruth, Grayson, Margaret, Cliona McDowell, Agus, Ashley, Annmarie Doran, McAuley, Danny F., Thomas, Anne L., Barnes, Rosemary A., Adams, Richard, Chau, Ian, and Coyle, Vicky

Abstract

Additional file 2. Patient information sheet.

Published
2020
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10. The NeST (Neoadjuvant Systemic Therapy in Breast Cancer) Study: National Practice Questionnaire of United Kingdom Multi-Disciplinary Decision Making 

Author

Whitehead, Ian, primary, Irwin, Gareth, additional, Bannon, Finian, additional, Coles, Charlotte, additional, Copson, Ellen, additional, Cutress, Ramsey, additional, Dave, Rajiv, additional, Gardiner, Matthew, additional, Grayson, Margaret, additional, Holcombe, Chris, additional, Irshad, Sheeba, additional, O'Brien, Ciara, additional, O'Connell, Rachel, additional, Palmieri, Carlo, additional, Shaaban, Abeer, additional, Sharma, Nisha, additional, Singh, Jagdeep, additional, Potter, Shelley, additional, and McIntosh, Stuart, additional

Published
2021
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11. The NeST (Neoadjuvant Systemic Therapy in Breast Cancer) Study: National Practice Questionnaire of United Kingdom Multi-Disciplinary Decision Making

Author

Whitehead, Ian, primary, Irwin, Gareth, additional, Bannon, Finian, additional, Coles, Charlotte, additional, Copson, Ellen, additional, Cutress, Ramsey, additional, Dave, Rajiv, additional, Gardiner, Matthew, additional, Grayson, Margaret, additional, Holcombe, Chris, additional, Irshad, Sheeba, additional, O'Brien, Ciara, additional, O'Connell, Rachel, additional, Palmieri, Carlo, additional, Shaaban, Abeer, additional, Sharma, Nisha, additional, Singh, Jagdeep, additional, Potter, Shelley, additional, and McIntosh, Stuart, additional

Published
2020
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12. The NeST (Neoadjuvant Systemic Therapy in Breast Cancer Study): National Practice Questionnaire of United Kingdom Multidisciplinary Decision Making

Author

Whitehead, Ian, primary, Irwin, Gareth, additional, Bannon, Finian, additional, Coles, Charlotte, additional, Copson, Ellen, additional, Cutress, Ramsey, additional, Dave, Rajiv, additional, Gardiner, Matthew, additional, Grayson, Margaret, additional, Holcombe, Chris, additional, Irshad, Sheeba, additional, O'Brien, Ciara, additional, O'Connell, Rachel, additional, Palmieri, Carlo, additional, Shaaban, Abeer, additional, Sharma, Nisha, additional, Singh, Jagdeep, additional, Potter, Shelley, additional, and McIntosh, Stuart, additional

Published
2020
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13. Abstract P2-16-04: National utilisation of neoadjuvant systemic therapy and impact on surgical treatment - A prospective multi-centre cohort study

Author

McIntosh, Stuart A, primary, Irwin, Gareth W, additional, Bannon, Finian, additional, Coles, Charlotte, additional, Copson, Ellen, additional, Cutress, Ramsey, additional, Dave, Rajiv, additional, Grayson, Margaret, additional, Holcombe, Chris, additional, Irshad, Sheeba, additional, O'Brien, Ciara, additional, O'Connell, Rachel, additional, Palmieri, Carlo, additional, Shaaban, Abeer M, additional, Sharma, Nisha, additional, Singh, Jagdeep, additional, Whitehead, Ian, additional, and Potter, Shelley, additional

Published
2020
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14. DESTINATION NEW ENGLAND.

Author

Grayson, Margaret, Davis, Meredith, and Fucillo, Rita A.

Abstract

A travel trip is offered to New England and offers recommendations for art galleries including Vermont Artisan Designs, and Harmony Collective.

Published
2021

15. Coding bootcamp: the future of computer science?

Author

Grayson, Margaret

Subjects
College enrollment, Web site design, Computer science, News, opinion and commentary, Sports and fitness
Abstract

Byline: Margaret Grayson The Montana Code School is a new Missoula program where participants will receive a crash course in web development and programming, all without ever enrolling in a [...]

Published
2018

16. UM research takes a closer look at concussions

Author

Grayson, Margaret

Subjects
Concussion -- Research, News, opinion and commentary, Sports and fitness
Abstract

Byline: Margaret Grayson A concussion is an invisible injury, hard to diagnose and even harder to treat. University of Montana researchers, however, are looking for a new way to monitor [...]

Published
2018

17. Professors address Hauck hiring and harassment at faculty meeting

Author

Grayson, Margaret

Subjects
Sexual abuse, News, opinion and commentary, Sports and fitness
Abstract

Byline: Margaret Grayson University of Montana professor Beth Hubble presented a letter to UM's faculty senate on Thursday opposing the hiring of Bobby Hauck as football coach. Hubble also said [...]

Published
2017

18. The EASI-SWITCH trial: Early switch to oral antibiotic therapy in patients with low risk neutropenic sepsis.

Author

Forde, Caroline, primary, McMullan, Ronan, additional, Clarke, Mike, additional, Wilson, Richard H., additional, Plummer, Elizabeth R., additional, Thomas, Anne L., additional, Barnes, Rosemary A, additional, Adams, Richard A., additional, Chau, Ian, additional, Grayson, Margaret, additional, McDowell, Cliona, additional, Agus, Ashley, additional, Brown, Ewan, additional, Storey, Dawn Jane, additional, McAuley, Danny, additional, and Coyle, Victoria, additional

Published
2016
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19. Delivering a research‐enabled multistakeholder partnership for enhanced patient care at a population level: The Northern Ireland Comprehensive Cancer Program

Author

Lawler, Mark, primary, Gavin, Anna, additional, Salto‐Tellez, Manuel, additional, Kennedy, Richard D., additional, Van Schaeybroeck, Sandra, additional, Wilson, Richard H., additional, Harkin, Denis Paul, additional, Grayson, Margaret, additional, Boyd, Ruth E., additional, Hamilton, Peter W., additional, McArt, Darragh G., additional, James, Jacqueline, additional, Robson, Tracy, additional, Ladner, Robert D., additional, Prise, Kevin M., additional, O'Sullivan, Joe M., additional, Harrison, Timothy, additional, Murray, Liam, additional, Johnston, Patrick G., additional, and Waugh, David J., additional

Published
2015
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20. End the PDA security dilemma

Author

Grayson, Margaret E.

Subjects
Telephone management device, Long-distance telephone service, Computer-telephone integration, Virtual private network, Systems/data security software, Open application interface, Personal digital assistant, Computer industry, Integrated voice/data, Intranet, Microcomputer industry, Pocket PC, Telecommunications equipment industry, Integrated voice/data -- Product information -- Safety and security measures, Systems and data security software -- Product information -- Usage -- Safety and security measures, Long-distance telephone service -- Usage -- Product information -- Safety and security measures, Telecommunications equipment industry -- Product information -- Safety and security measures, Virtual private networks -- Safety and security measures -- Usage -- Product information, Telephone management systems -- Product information -- Usage -- Safety and security measures, Personal digital assistants -- Usage -- Product information -- Safety and security measures, Intranets -- Product information -- Safety and security measures, Computer-Telephone integration -- Product information -- Safety and security measures, Computer industry -- Product information -- Safety and security measures
Abstract

Information passed from a personal device may not require strict control--yet! Virtual private networks (VPNs) and their attendant security features (e.g., firewalls, authentications) have linked scattered PCs with their corporate […]

Published
2001

21. MErCuRIC1: A Phase I study of MEK1/2 inhibitor PD-0325901 with cMET inhibitor crizotinib in RASMT and RASWT (with aberrant c-MET) metastatic colorectal cancer (mCRC) patients.

Author

Van Schaeybroeck, Sandra, primary, Rolfo, Christian D., additional, Élez, Elena, additional, Kelly, Stephen, additional, Houlden, Jennifer, additional, Collins, Linda, additional, Love, Sharon, additional, Andre, Thierry, additional, Lawler, Mark, additional, Di Nicolantonio, Federica, additional, Grayson, Margaret, additional, Popovici, Vlad Calin, additional, Bardelli, Alberto, additional, Laurent-Puig, Pierre, additional, Salto-Tellez, Manuel, additional, Maughan, Tim, additional, Tabernero, Josep, additional, Peeters, Marc, additional, Wilson, Richard H., additional, and Middleton, Mark R., additional

Published
2015
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26. A Comparison of La Crosse Virus Isolates Obtained from Different Ecological Niches and an Analysis of the Structural Components of California Encephalitis Serogroup Viruses and other Bunyaviruses *

Author

El Said, Laila Hamdy, primary, Bishop, David H. L., additional, Klimas, Richard A., additional, Thompson, Wayne H., additional, Trent, Dennis W., additional, Clewley, Jon P., additional, Calisher, Charles H., additional, Grayson, Margaret, additional, Vorndam, Vance, additional, and Gentsch, Jon R., additional

Published
1979
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35. Mountain High.

Author

Grayson, Margaret

Subjects
FLY fishing, FISHING equipment, CONFERENCES & conventions
Published
2017

36. Cash, not cans.

Author

Grayson, Margaret

Subjects
FOOD banks, CHARITIES
Published
2017

37. Agenda.

Author

Grayson, Margaret

Subjects
COMEDIANS
Published
2017

39. Up and out of downtown.

Author

Grayson, Margaret

Subjects
LANDLORDS, HOUSE construction, LAND tenure
Published
2017

43. Fixed Focus.

Author

Grayson, Margaret

Subjects
ROCK music, 2011-2020
Published
2017

44. STREET TALK.

Author

Brouwer, Derek and Grayson, Margaret

Subjects
BIRTHDAYS, BIRTHDAY parties
Published
2017

45. water works.

Author

Grayson, Margaret

Subjects
DRAWING exhibitions
Published
2017

46. dancing bubbles.

Author

Grayson, Margaret

Subjects
BUBBLES (Theatrical production), SALAMANDERS, The (Performer)
Published
2017

49. voices.

Author

Grayson, Margaret, Board, John C., and Sales, Walt

Subjects
MILLENNIALS, YOUTH in politics, POLITICAL campaigns, ELECTIONS & economics, ECONOMICS & politics, LEGISLATIVE bills
Published
2015

50. What's in store for 2002?

Author

Tomlinson, Gary, Zoufonoun, Amir, Sistanizadeh, Kamran, Giler, Eric, Odell, Chris, Winther, Mark, Liotta, Chris, Grayson, Margaret, and Odom, Howard

Subjects
*TELECOMMUNICATION, *FORECASTING
Abstract

Presents the forecasts of technology sector executives on telecommunication in 2002. Gary Tomlinson, chief technology officer at CacheFlow Inc.; Amir Zoufonoun, chief executive officer of Western Multiplex; Eric Giler, president and chief executive officer of Brooktrout Inc.

Published
2001

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