2,335 results on '"Gray, Nathanael S"'
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2. The dual HCK/BTK inhibitor KIN-8194 impairs growth and integrin-mediated adhesion of BTKi-resistant mantle cell lymphoma
3. Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism
4. Reciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry
5. Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF
6. Discovery of bivalent small molecule degraders of cyclin-dependent kinase 7 (CDK7)
7. Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues
8. Targeting transcription in heart failure via CDK7/12/13 inhibition
9. Rewiring cancer drivers to activate apoptosis
10. Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor
11. Author Correction: Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF
12. Inhibition of CDK4/6 promotes CD8 T-cell memory formation
13. Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias
14. Targeted kinase degradation via the KLHDC2 ubiquitin E3 ligase
15. The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma
16. The rise of degrader drugs
17. New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
18. CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma
19. Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling
20. USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
21. Development of potent and selective degraders of PI5P4Kγ
22. Author Correction: Rewiring cancer drivers to activate apoptosis
23. Exploring the target scope of KEAP1 E3 ligase-based PROTACs
24. Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
25. Synthesis and Structure–Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold
26. An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer
27. Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
28. Author Correction: Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation
29. Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library.
30. Disrupting the RNA polymerase II transcription cycle through CDK7 inhibition ameliorates inflammatory arthritis.
31. Discovery of Potent Degraders of the Dengue Virus Envelope Protein.
32. DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression.
33. Mammalian cell proliferation requires noncatalytic functions of O-GlcNAc transferase
34. Targeting transcription cycles in cancer
35. The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations
36. Proteasomal control of anti-CRISPRs for the regulation of CRISPR/Cas9 activity using Cas9-ACROBAT
37. Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma
38. Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo
39. Advancing targeted protein degrader discovery by measuring cereblon engagement in cells
40. A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
41. Acute pharmacological degradation of Helios destabilizes regulatory T cells
42. Discovery and resistance mechanism of a selective CDK12 degrader
43. Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
44. ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancer
45. Down-Regulation of AKT Proteins Slows the Growth of Mutant-KRAS Pancreatic Tumors.
46. Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing
47. Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities
48. Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors
49. Exploring Targeted Degradation Strategy for Oncogenic KRASG12C
50. Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation
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