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Pathological blood clotting, or thrombosis, limits vital blood flow to organs; such deprivation can lead to catastrophic events including myocardial infarction, pulmonary embolism, and ischemic stroke. Prompt restoration of blood flow greatly improves outcomes. We explored whether aptamers could serve as molecular imaging probes to rapidly detect thrombi. An aptamer targeting thrombin, Tog25t, was found to rapidly localize to and visualize pre-existing clots in the femoral and jugular veins of mice using fluorescence imaging and, when circulating, was able to image clots as they form. Since free aptamer is quickly cleared from circulation, contrast is rapidly developed, allowing clot visualization within minutes. Moreover, administration of an antidote oligonucleotide further enhanced contrast development, causing the unbound aptamer to clear within 5min while impacting the clot-bound aptamer more slowly. These findings suggest that aptamers can serve as imaging agents for rapid detection of thrombi in acute care and perioperative settings.

Grammatical complexity has been established as a key indicator of language and writing development (Ortega 2003; Bulté and Housen, 2014; Crossley and McNamara 2014). The present study uses the Register-Functional approach to complexity (Biber et al. 2022) to compare the development of L1 English and L2 English writers across year of study and discipline in the British Academic Written English corpus. It also introduces a novel method of examining developmental trajectories that uses both inferential statistics and descriptive measures to account not only for relationships between the year of study and use of linguistic features, but also for the shape of the trajectories and frequencies of occurrence over time. Statistical analyses reveal significant relationships for most of the complexity features. Means and confidence intervals indicate overall similarities in trends from early undergraduate to graduate-level writing across L1/L2 English writers, but also key differences in the developmental trajectories, including greater use of phrasal complexity features and less use of clausal features by L2 English writers in early levels, as well as distinct use of complexity features across certain disciplines.

In the present study, we take a longitudinal, corpus-based perspective to investigate short-term (over 9 months) linguistic change in the language produced for the spoken and written sections of the "TOEFL iBT"® test by a group of English-as-a-foreign-language (EFL) learners in China. The goal of the study is to identify patterns that characterize the trajectory that language learners move through in terms of their use of phrasal and clausal grammatical complexity, as mediated by mode (spoken and written) and task type (independent and integrated). Results of a multidimensional analysis reveal that in many cases, learners developed in expected ways: discourse styles at Time 1 were not always aligned with mode- and task type-specific discourse patterns but developed over time, with discourse styles at Time 2 better approximating expected norms and exhibiting increased task differentiation. These changes were particularly noteworthy for Dimension 1, which is related to phrasal and clausal complexity. Results of a developmental complexity analysis revealed more mixed results, seeming to indicate that the relatively low-proficiency learners represented by the longitudinal corpus may just be beginning on the hypothesized paths of development. The most important developments occurred for independent writing, in which students exhibited increases in the frequency of phrasal features, as well as functional expansion in the use of a range of complexity features.

Background: Parent‐mediated intervention (PMI) is a potentially scalable approach for tailored interventions in neurogenetic conditions like Down syndrome (DS). Because PMIs require ongoing parent engagement, they must be developed in alignment with the needs of intended users. The present study examined caregiver opinions and preferences to inform the development of syndrome‐informed interventions for children with DS. Method: Parents of children with DS (n = 34) participated in focus groups discussing PMI. Interviews were transcribed and a thematic analysis was applied to code the data. Results: Three themes were identified: advantages of PMI, disadvantages of PMI and preferred features of PMI. To align with parent preferences, future PMIs for children with DS should require a brief time commitment, blend intervention activities into daily routines and include family members in activities. Conclusions: Findings have implications for developing novel interventions to support early development in children with DS and other neurogenetic conditions. [ABSTRACT FROM AUTHOR]

The article discusses the importance of conducting grammatical analysis to describe grammatical complexity in learner language. It critiques the use of omnibus measures that overlook specific grammatical structures and syntactic functions, advocating for a more principled linguistic analysis. The authors argue that a comprehensive understanding of grammatical complexity in English learner language requires a detailed examination of grammatical structures and syntactic functions. They highlight the limitations of relying on general measures and emphasize the need for collaboration between SLA researchers and grammarians to develop linguistically adequate methods. [Extracted from the article]

Wearable robots are emerging as a viable and effective solution for assisting and enabling people who suffer from balance and mobility disorders. Virtual prototyping is a powerful tool to design robots, preventing the costly iterative physical prototyping and testing. Design of wearable robots through modelling, however, often involves computationally expensive and error-prone multi-body simulations wrapped in an optimization framework to simulate human–robot–environment interactions. This paper proposes a framework to make the human–robot link segment system statically determinate, allowing for the closed-form inverse dynamics formulation of the link–segment model to be solved directly in order to simulate human–robot dynamic interactions. The paper also uses a technique developed by the authors to estimate the walking ground reactions from reference kinematic data, avoiding the need to measure them. The proposed framework is (a) computationally efficient and (b) transparent and easy to interpret, and (c) eliminates the need for optimization, detailed musculoskeletal modelling and measuring ground reaction forces for normal walking simulations. It is used to optimise the position of hip and ankle joints and the actuator torque–velocity requirements for a seven segments of a lower-limb wearable robot that is attached to the user at the shoes and pelvis. Gait measurements were carried out on six healthy subjects, and the data were used for design optimization and validation. The new technique promises to offer a significant advance in the way in which wearable robots can be designed. [ABSTRACT FROM AUTHOR]

One of the major innovations of the "TOEFL iBT"® test is the incorporation of integrated tasks complementing the independent tasks to which examinees respond. In addition, examinees must produce discourse in both modes (speech and writing). The validity argument for the TOEFL iBT includes the claim that examinees vary their discourse in accordance with these considerations as they become more proficient in their academic language skills (the explanation inference). To provide evidence in support of this warrant, we undertake a comprehensive lexico-grammatical description of the discourse produced in response to integrated versus independent tasks, across the spoken and written modes, by test takers from different score levels. Discourse descriptions at several linguistic levels are provided, including vocabulary profiles, collocational patterns, the use of extended lexical bundles, distinctive lexicogrammatical features, and a multidimensional (MD) analysis that describes the overall patterns of linguistic variation. In sum, we undertake a comprehensive linguistic analysis of the discourse of TOEFL iBT responses, interpreting observed linguistic patterns of variation relative to three parameters that are relevant in the TOEFL iBT context: mode, task type, and score level of test takers.

College students represent a large portion of the population, and report high rates of cannabis use and related negative outcomes, including interpersonal problems, risky behaviors, or physical dependency. The contexts in which students use cannabis (e.g., at a party, when feeling down or depressed, after a fight with a loved one) likely affect their risk of experiencing consequences. We aimed to discern profiles of cannabis use contexts and compare profiles on use frequency, consequences, and the use of cannabis protective behavioral strategies (PBS). College students were surveyed regarding their cannabis use contexts, frequency, consequences, and PBS use (n = 265; female = 72.8%). We used Latent Profile Analysis to identify patterns of cannabis use contexts and auxiliary testing to compare profiles on use frequency, consequences, and PBS use. Our examination revealed three latent profiles of cannabis use. The Social Use Profile was associated with use in predominantly social/uplifting contexts. The Physical & Emotional Pain Profile was also associated with use in these contexts but was defined by additional use in response to pain. The All Contexts Profile was associated with frequent use in all contexts, including those that were least endorsed by the other profiles. Profiles differed in cannabis use frequency, PBS use, and the number of consequences experienced, such that profiles were more likely to be associated with more frequent cannabis use, higher risk of experiencing use-consequences, and using fewer PBS as the number of use contexts increased across the profiles. The contexts in which people use cannabis are associated with cannabis risk and protection. Prevention and intervention efforts may benefit from considering contexts of cannabis use. [ABSTRACT FROM AUTHOR]

We report the ALMA Band 7 observations of 86 Herschel sources that likely contain gravitationally lensed galaxies. These sources are selected with relatively faint 500 μ m flux densities between 15 and 85 mJy in an effort to characterize the effect of lensing across the entire million-source Herschel catalogue. These lensed candidates were identified by their close proximity to bright galaxies in the near-infrared VISTA Kilo-Degree Infrared Galaxy survey. Our high-resolution observations (0.15 arcsec) confirm 47 per cent of the initial candidates as gravitational lenses, while lensing cannot be excluded across the remaining sample. We find average lensing masses (log  M /M⊙ = 12.9 ± 0.5) in line with previous experiments, although direct observations might struggle to identify the most massive foreground lenses across the remaining 53 per cent of the sample, particularly for lenses with larger Einstein radii. Our observations confirm previous indications that more lenses exist at low flux densities than expected from strong galaxy–galaxy lensing models alone, where the excess is likely due to additional contributions of cluster lenses and weak lensing. If we apply our method across the total 660 square degree H-ATLAS field, it would allow us to robustly identify 3000 gravitational lenses across the 660 square degree Herschel ATLAS fields. [ABSTRACT FROM AUTHOR]

In the present article, we explore the extent to which previous research on register variation can be used to predict spoken/written task-type variation as well as differences across score levels in the context of a major standardized language exam (TOEFL iBT). Specifically, we carry out two sets of linguistic analyses based on a large corpus of TOEFL iBT responses: one investigating the use of 23 grammatical complexity features, and the second based on co-occurrence patterns among linguistic features, using Multi-Dimensional (MD) analysis. The first set of analyses confirms the predictions from research on register variation: there are systematic linguistic differences among spoken versus written and independent versus integrated task types. However, hypothesized developmental progressions in the use of these grammatical complexity features were generally not confirmed by score-level differences. In contrast, the MD analysis yielded more robust predictors of both task types and score-level differences, indicating that linguistic descriptions are more reliable and informative when they are based on dimensions of co-occurring lexico-grammatical features. In conclusion, we discuss the application of such dimensions as holistic complexity measures in language development/testing research.