Search

Your search keyword '"Grasso P"' showing total 5,814 results
Start Over Author "Grasso P"
5,814 results on '"Grasso P"'

1. A Fluorescent Ratiometric Potassium Sensor Based on IPG4-Silica Microparticles for Selective Detection and Fluorescence Imaging of Potassium Cations

Author

Colella, Francesco, Forciniti, Stefania, Onesto, Valentina, Grasso, Giuliana, Iuele, Helena, Gigli, Giuseppe, and del Mercato, Loretta L.

Subjects
Physics - Biological Physics, Physics - Chemical Physics
Abstract

Potassium cations play many important roles in living organisms, especially in electro-physiology, since they are involved in neurotransmission and muscle contractions. We report the synthesis of a ratiometric fluorescent microsensor for potassium (K+) detection, based on the fluorescent probe ION potassium green 4. Potassium-sensitive fluorescent microparticles were obtained by using silica as core material. We obtained silica-based microsensors with a size in the micrometer range, spherical shape, good monodispersity, optimal selectivity and a sensitivity range between 0 to 40 mM. The microsensors also proved to be non-toxic in cell cultures as well as suitable for fluorescent imaging, offering new possibilities for non-invasive optical detection, quantification and in situ monitoring of K+ variations in cell culture systems.

Published
2024
Full Text
View/download PDF

2. Multiplicities of positive and negative pions, kaons and unidentified hadrons from deep-inelastic scattering of muons off a liquid hydrogen target

Author

Alexeev, G. D., Alexeev, M. G., Alice, C., Amoroso, A., Andrieux, V., Anosov, V., Augsten, K., Augustyniak, W., Azevedo, C. D. R., Badelek, B., Barth, J., Beck, R., Beckers, J., Bedfer, Y., Bernhard, J., Bodlak, M., Bradamante, F., Bressan, A., Chang, W. -C., Chatterjee, C., Chiosso, M., Chung, S. -U., Cicuttin, A., Correia, P. M. M., Crespo, M. L., D'Ago, D., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Delcarro, F., Denisenko, I., Denisov, O. Yu., Donskov, S. V., Doshita, N., Dreisbach, Ch., Dünnweber, W., Dusaev, R. R., Ecker, D., Eremeev, D., Faccioli, P., Faessler, M., Finger, M., Finger jr., M., Fischer, H., Flöthner, K. J., Florian, W., Friedrich, J. M., Frolov, V., Ordòñez, L. G. Garcia, Gavrichtchouk, O. P., Gerassimov, S., Giarra, J., Giordano, D., Grasso, A., Gridin, A., Perdekamp, M. Grosse, Grube, B., Grüner, M., Guskov, A., Haas, P., von Harrach, D., Hoffmann, M., d'Hose, N., Hsieh, C. -Y., Ishimoto, S., Ivanov, A., Iwata, T., Jary, V., Joosten, R., Kabuß, E., Kaspar, F., Kerbizi, A., Ketzer, B., Khatun, A., Khaustov, G. V., Klein, F., Koivuniemi, J. H., Kolosov, V. N., Horikawa, K. Kondo, Konorov, I., Korzenev, A. Yu., Kotzinian, A. M., Kouznetsov, O. M., Koval, A., Kral, Z., Kunne, F., Kurek, K., Kurjata, R. P., Lavickova, K., Levorato, S., Lian, Y. -S., Lichtenstadt, J., Lin, P. -J., Longo, R., Lyubovitskij, V. E., Maggiora, A., Makke, N., Mallot, G. K., Maltsev, A., Martin, A., Marzec, J., Matoušek, J., Matsuda, T., Pires, C. Menezes, Metzger, F., Meyer, W., Mikhailov, Yu. V., Mikhasenko, M., Mitrofanov, E., Miura, D., Miyachi, Y., Molina, R., Moretti, A., Nagaytsev, A., Neyret, D., Niemiec, M., Nový, J., Nowak, W. -D., Nukazuka, G., Olshevsky, A. G., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Pekeler, H., Peng, J. -C., Pešek, M., Peshekhonov, D. V., Pešková, M., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Quintans, C., Reicherz, G., Riedl, C., Ryabchikov, D. I., Rychter, A., Rymbekova, A., Samoylenko, V. D., Sandacz, A., Sarkar, S., Savin, I. A., Sbrizzai, G., Schmieden, H., Selyunin, A., Sinha, L., Spülbeck, D., Srnka, A., Stolarski, M., Sulc, M., Suzuki, H., Tessaro, S., Tessarotto, F., Thiel, A., Tosello, F., Townsend, A., Triloki, T., Tskhay, V., Valinoti, B., Veit, B. M., Veloso, J. F. C. A., Vijayakumar, A., Virius, M., Wagner, M., Wallner, S., Zaremba, K., Zavertyaev, M., Zemko, M., Zemlyanichkina, E., and Ziembicki, M.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

The multiplicities of positive and negative pions, kaons and unidentified hadrons produced in deep-inelastic scattering are measured in bins of the Bjorken scaling variable $x$, the relative virtual-photon energy $y$ and the fraction of the virtual-photon energy transferred to the final-state hadron $z$. Data were obtained by the COMPASS Collaboration using a 160 GeV muon beam of both electric charges and a liquid hydrogen target. These measurements cover the kinematic domain with photon virtuality $Q^2 > 1$ (GeV/$c)^2$, $0.004 < x < 0.4$, $0.1 < y < 0.7$ and $0.2 < z < 0.85$, in accordance with the kinematic domain used in earlier published COMPASS multiplicity measurements with an isoscalar target. The calculation of radiative corrections was improved by using the Monte Carlo generator DJANGOH, which results in up to 12\% larger corrections in the low-$x$ region., Comment: 19 pages, 29 figures

Published
2024

3. Gravitational Waves and Black Hole perturbations in Acoustic Analogues

Author

Coviello, Chiara, Chiofalo, Maria Luisa, Grasso, Dario, Liberati, Stefano, Mannarelli, Massimo, and Trabucco, Silvia

Subjects
General Relativity and Quantum Cosmology, Condensed Matter - Quantum Gases, High Energy Physics - Phenomenology
Abstract

Phonons in Bose-Einstein condensates propagate as massless scalar particles on top of an emergent acoustic metric. This hydrodynamics/gravity analogy can be exploited to realize acoustic black holes, featuring an event horizon that traps phonons. We show that by appropriately perturbing the background fluid, gravitational wave-like fluctuations of the acoustic metric can be produced. Such fluctuations can be used to excite an acoustic black hole, which should then relax by phonon emission.

Published
2024

4. Is Motherhood a Burden or an Asset to Female Computer Science and Engineering Faculty? Case Studies in China and Italy

Author

Biying Wen, Qian Wang, Floriana Grasso, Qing Chen, and Juming Shen

Abstract

The problem of gender disparity in computer science and engineering has persisted despite longstanding efforts made in higher education. This study drew data from ten female computer science and engineering faculty in China and Italy to demonstrate the gender-specific challenges they face. The researcher applied positioning theory to analyse female faculty's motherhood experiences. Findings suggest that the dual mother-and-educator role conflict in the intersectional space of work and family can be both a burden and an asset to female faculty. As a burden, the sociocultural expectations of the mother's role drive females to take on primary childcare responsibilities. It leads to significant barriers to female faculty's career advancements. As an asset, the study finds that the female faculty's motherhood experience allowed them to generate new insights into their identities as educators and teaching practices. Their learning from motherhood prompts them to reflect and gain an appreciation of their educator identity. Such realisation enables them to improve their teaching practices and interactions with students. The study offers policy recommendations for higher education institutions to support female faculty navigating the dual roles of mother and educator. Finally, the researcher discusses the limitations and directions for future study.

Published
2024
Full Text
View/download PDF

5. Assessing Generative Language Models in Classification Tasks: Performance and Self-Evaluation Capabilities in the Environmental and Climate Change Domain

Author

Grasso, Francesca and Locci, Stefano

Subjects
Computer Science - Computation and Language
Abstract

This paper examines the performance of two Large Language Models (LLMs), GPT3.5 and Llama2 and one Small Language Model (SLM) Gemma, across three different classification tasks within the climate change (CC) and environmental domain. Employing BERT-based models as a baseline, we compare their efficacy against these transformer-based models. Additionally, we assess the models' self-evaluation capabilities by analyzing the calibration of verbalized confidence scores in these text classification tasks. Our findings reveal that while BERT-based models generally outperform both the LLMs and SLM, the performance of the large generative models is still noteworthy. Furthermore, our calibration analysis reveals that although Gemma is well-calibrated in initial tasks, it thereafter produces inconsistent results; Llama is reasonably calibrated, and GPT consistently exhibits strong calibration. Through this research, we aim to contribute to the ongoing discussion on the utility and effectiveness of generative LMs in addressing some of the planet's most urgent issues, highlighting their strengths and limitations in the context of ecology and CC., Comment: 11 pages, to be published in NLDB 2024

Published
2024

6. Deep-Learning-Based Markerless Pose Estimation Systems in Gait Analysis: DeepLabCut Custom Training and the Refinement Function

Author

Panconi, Giulia, Grasso, Stefano, Guarducci, Sara, Mucchi, Lorenzo, Minciacchi, Diego, and Bravi, Riccardo

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

The current gold standard for the study of human movement is the marker-based motion capture system that offers high precision but constrained by costs and controlled environments. Markerless pose estimation systems emerge as ecological alternatives, allowing unobtrusive data acquisition in natural settings. This study compares the performance of two popular markerless systems, OpenPose (OP) and DeepLabCut (DLC), in assessing locomotion. Forty healthy subjects walked along a 5 meters walkway equipped with four force platforms and a camera. Gait parameters were obtained using OP BODY 25 Pre-Trained model (OPPT), DLC Model Zoo full human Pre-Trained model (DLCPT) and DLC Custom-Trained model (DLCCT), then compared with those acquired from the force platforms as reference system. Our results demonstrated that DLCCT outperformed DLCPT and OPPT, highlighting the importance of leveraging DeepLabCut transfer learning to enhance the pose estimation performance with a custom-trained neural networks. Moreover, DLCCT, with the implementation of the DLC refinement function, offers the most promising markerless pose estimation solution for evaluating locomotion. Therefore, our data provide insights into the DLC training and refinement processes required to achieve optimal performance. This study offers perspectives for clinicians and practitioners seeking accurate low-cost methods for movement assessment beyond laboratory settings.

Published
2024

7. Comparing the thermal performance of Living Lab monitoring and simulation with different level of input detail

Author

Zinzi Michele, Botticelli Martina, Fasano Francesca, Grasso Paolo, and Chiesa Giacomo

Subjects
Environmental sciences, GE1-350
Abstract

Dynamic envelope solutions are critical to achieve comfort conditions minimizing the need of active air conditioning systems, emphasizing the potential of thermal adaption of the building occupants. Dynamic systems are, however, difficult to be implemented in European building energy certification schemes, based on semi-stationary calculation method, standard uses and reference boundary conditions. In the attempt to develop a flexible and dynamic method able to reduce the performance gap between real and expected performance, this paper presents the comparison between measurements and simulations of a Living Lab office operated in thermal free floating, with different strategies for the solar protection and the night ventilative cooling. Simulations were performed using the dynamic platform PREDYCE, which allows for manipulating monitored and simulated data. The first phase was dedicated to the model calibration using the indoor air temperature as relevant indicator against monitored data. The coefficient of variation of the root mean squared error is in the 8-9% range. Building simulations of the calibrated model demonstrated a large variation of the results as a function of the input data, with increase of discomfort hour up to a factor 20 and a reduction of discomfort hours up to 95%.

Published
2023
Full Text
View/download PDF

8. LightCPPgen: An Explainable Machine Learning Pipeline for Rational Design of Cell Penetrating Peptides

Author

Maroni, Gabriele, Stojceski, Filip, Pallante, Lorenzo, Deriu, Marco A., Piga, Dario, and Grasso, Gianvito

Subjects
Quantitative Biology - Biomolecules, Computer Science - Machine Learning, Computer Science - Neural and Evolutionary Computing
Abstract

Cell-penetrating peptides (CPPs) are powerful vectors for the intracellular delivery of a diverse array of therapeutic molecules. Despite their potential, the rational design of CPPs remains a challenging task that often requires extensive experimental efforts and iterations. In this study, we introduce an innovative approach for the de novo design of CPPs, leveraging the strengths of machine learning (ML) and optimization algorithms. Our strategy, named LightCPPgen, integrates a LightGBM-based predictive model with a genetic algorithm (GA), enabling the systematic generation and optimization of CPP sequences. At the core of our methodology is the development of an accurate, efficient, and interpretable predictive model, which utilizes 20 explainable features to shed light on the critical factors influencing CPP translocation capacity. The CPP predictive model works synergistically with an optimization algorithm, which is tuned to enhance computational efficiency while maintaining optimization performance. The GA solutions specifically target the candidate sequences' penetrability score, while trying to maximize similarity with the original non-penetrating peptide in order to retain its original biological and physicochemical properties. By prioritizing the synthesis of only the most promising CPP candidates, LightCPPgen can drastically reduce the time and cost associated with wet lab experiments. In summary, our research makes a substantial contribution to the field of CPP design, offering a robust framework that combines ML and optimization techniques to facilitate the rational design of penetrating peptides, by enhancing the explainability and interpretability of the design process.

Published
2024

9. From Data Complexity to User Simplicity: A Framework for Linked Open Data Reconciliation and Serendipitous Discovery

Author

Grasso, Marco, Renda, Giulia, and Daquino, Marilena

Subjects
Computer Science - Information Retrieval
Abstract

This article introduces a novel software solution to create a Web portal to align Linked Open Data sources and provide user-friendly interfaces for serendipitous discovery. We present the Polifonia Web portal as a motivating scenario and case study to address research problems such as data reconciliation and serving generous interfaces in the music heritage domain., Comment: 6 pages, 3 figures, part of "XIII Convegno Annuale AIUCD 2024 Proceedings"

Published
2024

10. Highly Sensitive Ratiometric Fluorescent Fiber Matrixes for Oxygen Sensing with Micrometer-Spatial Resolution

Author

Grasso, Giuliana, Onesto, Valentina, Forciniti, Stefania, Amone, Eliana D, Colella, Francesco, Pierantoni, Lara, Fama, Valeria, Gigli, Giuseppe, Reis, Rui L., Oliveira, Joaquim M., and del Mercato, Loretta L.

Subjects
Physics - Biological Physics
Abstract

Oxygen (O2)-sensing matrices are promising tools for the live monitoring of extracellular O2 consumption levels in long-term cell cultures. In this study, ratiometric O2-sensing membranes were prepared by electrospinning, an easy, low-cost, scalable, and robust method for fabricating nanofibers. Poly({\epsilon}-caprolactone) and poly(dimethyl)siloxane polymers were blended with tris(4,7-diphenyl-1,10-phenanthroline) ruthenium(II) dichloride, which was used as the O2-sensing probe, and rhodamine B isothiocyanate, which was used as the reference dye. The functionalized scaffolds were morphologically characterized by scanning electron microscopy, and their physicochemical profiles were obtained by Fourier transform infrared spectroscopy, thermogravimetric analysis, and water contact angle measurement. The sensing capabilities were investigated by confocal laser scanning microscopy, performing photobleaching, reversibility, and calibration curve studies toward different dissolved O2 (DO) concentrations. Electrospun sensing nanofibers showed a high response to changes in DO concentrations in the physiological-pathological range from 0.5 to 20% and good stability under ratiometric imaging. In addition, the sensing systems were highly biocompatible for cell growth promoting adhesiveness and growth of three cancer cell lines, namely metastatic melanoma cell line SK-MEL2, breast cancer cell line MCF-7, and pancreatic ductal adenocarcinoma cell line Panc-1, thus recreating a suitable biological environment in vitro. These O2-sensing biomaterials can potentially measure alterations in cell metabolism caused by changes in ambient O2 content during drug testing/validation and tissue regeneration processes., Comment: 15 pages, 4 figures

Published
2024
Full Text
View/download PDF

11. EcoVerse: An Annotated Twitter Dataset for Eco-Relevance Classification, Environmental Impact Analysis, and Stance Detection

Author

Grasso, Francesca, Locci, Stefano, Siragusa, Giovanni, and Di Caro, Luigi

Subjects
Computer Science - Computation and Language
Abstract

Anthropogenic ecological crisis constitutes a significant challenge that all within the academy must urgently face, including the Natural Language Processing (NLP) community. While recent years have seen increasing work revolving around climate-centric discourse, crucial environmental and ecological topics outside of climate change remain largely unaddressed, despite their prominent importance. Mainstream NLP tasks, such as sentiment analysis, dominate the scene, but there remains an untouched space in the literature involving the analysis of environmental impacts of certain events and practices. To address this gap, this paper presents EcoVerse, an annotated English Twitter dataset of 3,023 tweets spanning a wide spectrum of environmental topics. We propose a three-level annotation scheme designed for Eco-Relevance Classification, Stance Detection, and introducing an original approach for Environmental Impact Analysis. We detail the data collection, filtering, and labeling process that led to the creation of the dataset. Remarkable Inter-Annotator Agreement indicates that the annotation scheme produces consistent annotations of high quality. Subsequent classification experiments using BERT-based models, including ClimateBERT, are presented. These yield encouraging results, while also indicating room for a model specifically tailored for environmental texts. The dataset is made freely available to stimulate further research.

Published
2024

12. MPXGAT: An Attention based Deep Learning Model for Multiplex Graphs Embedding

Author

Bongiovanni, Marco, Gallo, Luca, Grasso, Roberto, and Pulvirenti, Alfredo

Subjects
Computer Science - Machine Learning, Computer Science - Discrete Mathematics, Computer Science - Social and Information Networks
Abstract

Graph representation learning has rapidly emerged as a pivotal field of study. Despite its growing popularity, the majority of research has been confined to embedding single-layer graphs, which fall short in representing complex systems with multifaceted relationships. To bridge this gap, we introduce MPXGAT, an innovative attention-based deep learning model tailored to multiplex graph embedding. Leveraging the robustness of Graph Attention Networks (GATs), MPXGAT captures the structure of multiplex networks by harnessing both intra-layer and inter-layer connections. This exploitation facilitates accurate link prediction within and across the network's multiple layers. Our comprehensive experimental evaluation, conducted on various benchmark datasets, confirms that MPXGAT consistently outperforms state-of-the-art competing algorithms.

Published
2024

13. Dark Matter Line Searches with the Cherenkov Telescope Array

Author

Abe, S., Abhir, J., Abhishek, A., Acero, F., Acharyya, A., Adam, R., Aguasca-Cabot, A., Agudo, I., Aguirre-Santaella, A., Alfaro, J., Alfaro, R., Alvarez-Crespo, N., Batista, R. Alves, Amans, J. -P., Amato, E., Ambrosi, G., Angel, L., Aramo, C., Arcaro, C., Arnesen, T. T. H., Arrabito, L., Asano, K., Ascasibar, Y., Aschersleben, J., Ashkar, H., Backes, M., Baktash, A., Balazs, C., Balbo, M., Larriva, A. Baquero, Martins, V. Barbosa, de Almeida, U. Barres, Barrio, J. A., Batković, I., Batzofin, R., Baxter, J., González, J. Becerra, Beck, G., Benbow, W., Berge, D., Bernardini, E., Bernete, J., Bernlöhr, K., Berti, A., Bertucci, B., Bhattacharjee, P., Bhattacharyya, S., Bigongiari, C., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Bocchino, F., Boisson, C., Bolmont, J., Bonnoli, G., Bonollo, A., Bordas, P., Bosnjak, Z., Bottacini, E., Böttcher, M., Bringmann, T., Bronzini, E., Brose, R., Brown, A. M., Brunelli, G., Bulgarelli, A., Bulik, T., Burelli, I., Burmistrov, L., Burton, M., Buscemi, M., Bylund, T., Cailleux, J., Campoy-Ordaz, A., Cantlay, B. K., Capasso, G., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Caroff, S., Carosi, A., Carosi, R., Carquin, E., Carrasco, M. -S., Cassol, F., Castaldini, L., Castrejon, N., Castro-Tirado, A. J., Cerasole, D., Cerruti, M., Chadwick, P. M., Chaty, S., Chen, A. W., Chernyakova, M., Chiavassa, A., Chudoba, J., Chytka, L., Cicciari, G. M., Cifuentes, A., Araujo, C. H. Coimbra, Colapietro, M., Conforti, V., Conte, F., Contreras, J. L., Costa, A., Costantini, H., Cotter, G., Cristofari, P., Cuevas, O., Curtis-Ginsberg, Z., D'Amico, G., D'Ammando, F., Dai, S., Dalchenko, M., Dazzi, F., De Angelis, A., de Lavergne, M. de Bony, De Caprio, V., Pino, E. M. de Gouveia Dal, De Lotto, B., De Lucia, M., de Menezes, R., de Naurois, M., de Souza, V., del Peral, L., del Valle, M. V., Giler, A. G. Delgado, Mengual, J. Delgado, Delgado, C., Dell'aiera, M., della Volpe, D., Depaoli, D., Di Girolamo, T., Di Piano, A., Di Pierro, F., Di Tria, R., Di Venere, L., Díaz, C., Diebold, S., Dinesh, A., Djuvsland, J., Dominik, R. M., Prester, D. Dominis, Donini, A., Dorner, D., Dörner, J., Doro, M., Dournaux, J. -L., Duangchan, C., Dubos, C., Ducci, L., Dwarkadas, V. V., Ebr, J., Eckner, C., Egberts, K., Einecke, S., Elsässer, D., Emery, G., Errando, M., Escanuela, C., Escarate, P., Godoy, M. Escobar, Escudero, J., Esposito, P., Ettori, S., Falceta-Goncalves, D., Fedorova, E., Fegan, S., Feng, Q., Ferrand, G., Ferrarotto, F., Fiandrini, E., Fiasson, A., Filipovic, M., Fioretti, V., Fiori, M., Foffano, L., Guiteras, L. Font, Fontaine, G., Fröse, S., Fukazawa, Y., Fukui, Y., Furniss, A., Galanti, G., Galaz, G., Galelli, C., Gallozzi, S., Gammaldi, V., Garczarczyk, M., Gasbarra, C., Gasparrini, D., Ghalumyan, A., Gianotti, F., Giarrusso, M., Paiva, J. G. Giesbrecht Formiga, Giglietto, N., Giordano, F., Giuffrida, R., Glicenstein, J. -F., Glombitza, J., Goldoni, P., González, J. M., González, M. M., Coelho, J. Goulart, Gradetzke, T., Granot, J., Grasso, D., Grau, R., Gréaux, L., Green, D., Green, J. G., Grolleron, G., Guedes, L. M. V., Gueta, O., Hackfeld, J., Hadasch, D., Hamal, P., Hanlon, W., Hara, S., Harvey, V. M., Hassan, T., Hayashi, K., Heß, B., Heckmann, L., Heller, M., Cadena, S. Hernández, Hervet, O., Hinton, J., Hiroshima, N., Hnatyk, B., Hnatyk, R., Hofmann, W., Holder, J., Horan, D., Horvath, P., Hovatta, T., Hrabovsky, M., Hrupec, D., Iarlori, M., Inada, T., Incardona, F., Inoue, S., Inoue, Y., Iocco, F., Iori, M., Ishio, K., Jamrozy, M., Janecek, P., Jankowsky, F., Jean, P., Quiles, J. Jimenez, Jin, W., Juramy-Gilles, C., Jurysek, J., Kagaya, M., Kalekin, O., Karas, V., Katagiri, H., Kataoka, J., Kaufmann, S., Kazanas, D., Kerszberg, D., Kieda, D. B., Kleiner, T., Kluge, G., Kobayashi, Y., Kohri, K., Komin, N., Kornecki, P., Kosack, K., Kowal, G., Kubo, H., Kushida, J., La Barbera, A., La Palombara, N., Láinez, M., Lamastra, A., Lapington, J., Laporte, P., Lazarević, S., Lazendic-Galloway, J., Lemoine-Goumard, M., Lenain, J. -P., Leone, F., Leonora, E., Leto, G., Lindfors, E., Linhoff, M., Liodakis, I., Lipniacka, A., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Bahilo, J. Lozano, Luque-Escamilla, P. L., Macias, O., Majumdar, P., Mallamaci, M., Malyshev, D., Mandat, D., Manicò, G., Mariotti, M., Márquez, I., Marquez, P., Marsella, G., Martí, J., Martínez, G. A., Martínez, M., Martinez, O., Marty, C., Mas-Aguilar, A., Mastropietro, M., Mazin, D., Menchiari, S., Mestre, E., Meunier, J. -L., Meyer, D. M. -A., Meyer, M., Miceli, D., Miceli, M., Michailidis, M., Michałowski, J., Miener, T., Miranda, J. M., Mitchell, A., Mizote, M., Mizuno, T., Moderski, R., Molero, M., Molfese, C., Molina, E., Montaruli, T., Moralejo, A., Morcuende, D., Morselli, A., Moulin, E., Zamanillo, V. Moya, Munari, K., Murach, T., Muraczewski, A., Muraishi, H., Nakamori, T., Nayak, A., Nemmen, R., Neto, J. P., Nickel, L., Niemiec, J., Nieto, D., Rosillo, M. Nievas, Nikołajuk, M., Nikolić, L., Nishijima, K., Noda, K., Nosek, D., Novotny, V., Nozaki, S., Ohishi, M., Ohtani, Y., Okumura, A., Olive, J. -F., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, E., Orlando, S., Ostrowski, M., Otero-Santos, J., Oya, I., Pagano, I., Pagliaro, A., Palatiello, M., Panebianco, G., Paneque, D., Pantaleo, F. R., Paredes, J. M., Parmiggiani, N., Patricelli, B., Pe'er, A., Pech, M., Pecimotika, M., Pensec, U., Peresano, M., Pérez-Romero, J., Persic, M., Peters, K. P., Petruk, O., Piano, G., Pierre, E., Pietropaolo, E., Pihet, M., Pinchbeck, L., Pirola, G., Pittori, C., Plard, C., Podobnik, F., Pohl, M., Pollet, V., Ponti, G., Prandini, E., Principe, G., Priyadarshi, C., Produit, N., Prouza, M., Pueschel, E., Pühlhofer, G., Pumo, M. L., Queiroz, F., Quirrenbach, A., Rainò, S., Rando, R., Razzaque, S., Regeard, M., Reimer, A., Reimer, O., Reisenegger, A., Rhode, W., Ribeiro, D., Ribó, M., Ricci, C., Richtler, T., Rico, J., Rieger, F., Riitano, L., Rizi, V., Roache, E., Fernandez, G. Rodriguez, Frías, M. D. Rodríguez, Rodríguez-Vázquez, J. J., Romano, P., Romeo, G., Rosado, J., de Leon, A. Rosales, Rowell, G., Rudak, B., Ruiter, A. J., Rulten, C. B., Sadeh, I., Saha, L., Saito, T., Salzmann, H., Sánchez-Conde, M., Sandaker, H., Sangiorgi, P., Sano, H., Santander, M., Santos-Lima, R., Sapienza, V., Šarić, T., Sarkar, A., Sarkar, S., Saturni, F. G., Savarese, S., Scherer, A., Schiavone, F., Schipani, P., Schleicher, B., Schovanek, P., Schubert, J. L., Schwanke, U., Arroyo, M. Seglar, Seitenzahl, I. R., Sergijenko, O., Servillat, M., Siegert, T., Siejkowski, H., Siqueira, C., Sliusar, V., Slowikowska, A., Sol, H., Spencer, S. T., Spiga, D., Stamerra, A., Stanič, S., Starecki, T., Starling, R., Stawarz, Ł., Steppa, C., Hatlen, E. Sæther, Stolarczyk, T., Strišković, J., Suda, Y., Świerk, P., Tajima, H., Tak, D., Takahashi, M., Takeishi, R., Tavernier, T., Tejedor, L. A., Terauchi, K., Teshima, M., Testa, V., Tian, W. W., Tibaldo, L., Tibolla, O., Peixoto, C. J. Todero, Torradeflot, F., Torres, D. F., Tosti, G., Tothill, N., Toussenel, F., Tramacere, A., Travnicek, P., Tripodo, G., Trois, A., Truzzi, S., Tutone, A., Vaclavek, L., Vacula, M., Vallania, P., Vallés, R., van Eldik, C., van Scherpenberg, J., Vandenbroucke, J., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Ventura, S., Vercellone, S., Verna, G., Viana, A., Viaux, N., Vigliano, A., Vignatti, J., Vigorito, C. F., Villanueva, J., Visentin, E., Vitale, V., Vodeb, V., Voisin, V., Voitsekhovskyi, V., Vorobiov, S., Voutsinas, G., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., White, M., White, R., Wierzcholska, A., Will, M., Williams, D. A., Wohlleben, F., Wolter, A., Yamamoto, T., Yang, L., Yoshida, T., Yoshikoshi, T., Zaharijas, G., Zampieri, L., Sanchez, R. Zanmar, Zavrtanik, D., Zavrtanik, M., Zdziarski, A. A., Zech, A., Zhang, W., Zhdanov, V. I., Ziętara, K., Živec, M., and Zuriaga-Puig, J.

Subjects
High Energy Physics - Phenomenology, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

Monochromatic gamma-ray signals constitute a potential smoking gun signature for annihilating or decaying dark matter particles that could relatively easily be distinguished from astrophysical or instrumental backgrounds. We provide an updated assessment of the sensitivity of the Cherenkov Telescope Array (CTA) to such signals, based on observations of the Galactic centre region as well as of selected dwarf spheroidal galaxies. We find that current limits and detection prospects for dark matter masses above 300 GeV will be significantly improved, by up to an order of magnitude in the multi-TeV range. This demonstrates that CTA will set a new standard for gamma-ray astronomy also in this respect, as the world's largest and most sensitive high-energy gamma-ray observatory, in particular due to its exquisite energy resolution at TeV energies and the adopted observational strategy focussing on regions with large dark matter densities. Throughout our analysis, we use up-to-date instrument response functions, and we thoroughly model the effect of instrumental systematic uncertainties in our statistical treatment. We further present results for other potential signatures with sharp spectral features, e.g.~box-shaped spectra, that would likewise very clearly point to a particle dark matter origin., Comment: 44 pages JCAP style (excluding author list and references), 19 figures; minor changes to match published version

Published
2024
Full Text
View/download PDF

14. Fluorescent nano- and microparticles for sensing cellular microenvironment: past, present and future applications

Author

Grasso, Giuliana, Colella, Francesco, Forciniti, Stefania, Onesto, Valentina, Iuele, Helena, Siciliano, Anna Chiara, Carnevali, Federica, Chandra, Anil, Gigli, Giuseppe, and del Mercato, Loretta L.

Subjects
Physics - Applied Physics, Physics - Biological Physics
Abstract

The tumor microenvironment (TME) features distinct hallmarks, including acidosis, hypoxia, reactive oxygen species (ROS) generation, and altered ion fluxes, which are crucial targets for early cancer biomarker detection, tumor diagnosis, and therapeutic strategies. A variety of imaging and sensing techniques have been developed and employed in both research and clinical settings to visualize and monitor cellular and TME dynamics. Among these, ratiometric fluorescence-based sensors have emerged as powerful analytical tools, providing precise and sensitive insights into the TME and enabling real-time detection and tracking of dynamic changes. In this comprehensive review, we discuss the latest advancements in ratiometric fluorescent probes designed for optical mapping of pH, oxygen, ROS, ions, and biomarkers within the TME. We elucidate their structural designs and sensing mechanisms, as well as their applications in in vitro and in vivo detection. Furthermore, we explore integrated sensing platforms that reveal the spatiotemporal behavior of complex tumor cultures, highlighting the potential of high-resolution imaging techniques combined with computational methods. This review aims to provide a solid foundation for understanding the current state of the art and the future potential of fluorescent nano- and microparticles in the field of cellular microenvironment sensing.

Published
2024
Full Text
View/download PDF

23. A System Development Kit for Big Data Applications on FPGA-based Clusters: The EVEREST Approach

Author

Pilato, Christian, Banik, Subhadeep, Beranek, Jakub, Brocheton, Fabien, Castrillon, Jeronimo, Cevasco, Riccardo, Cmar, Radim, Curzel, Serena, Ferrandi, Fabrizio, Friebel, Karl F. A., Galizia, Antonella, Grasso, Matteo, Silva, Paulo, Martinovic, Jan, Palermo, Gianluca, Paolino, Michele, Parodi, Andrea, Parodi, Antonio, Pintus, Fabio, Polig, Raphael, Poulet, David, Regazzoni, Francesco, Ringlein, Burkhard, Rocco, Roberto, Slaninova, Katerina, Slooff, Tom, Soldavini, Stephanie, Suchert, Felix, Tibaldi, Mattia, Weiss, Beat, and Hagleitner, Christoph

Subjects
Computer Science - Hardware Architecture
Abstract

Modern big data workflows are characterized by computationally intensive kernels. The simulated results are often combined with knowledge extracted from AI models to ultimately support decision-making. These energy-hungry workflows are increasingly executed in data centers with energy-efficient hardware accelerators since FPGAs are well-suited for this task due to their inherent parallelism. We present the H2020 project EVEREST, which has developed a system development kit (SDK) to simplify the creation of FPGA-accelerated kernels and manage the execution at runtime through a virtualization environment. This paper describes the main components of the EVEREST SDK and the benefits that can be achieved in our use cases., Comment: Accepted for presentation at DATE 2024 (multi-partner project session)

Published
2024

24. Visual acuity and contrast sensitivity under monochromatic yellow light

Author

Baldanzi, Elisabetta, Grasso, Paolo Antonino, Gori, Clara, Gurioli, Massimo, Tommasi, Federcio, and Farini, Alessandro

Subjects
Quantitative Biology - Quantitative Methods, Physics - Medical Physics
Abstract

This study investigates the impact of monochromatic lighting on visual acuity (VA) and contrast sensitivity (CS). Traditional assessments of VA and CS are typically conducted under the illumination of ``white'' light, but variations in color temperature can influence outcomes. Utilizing data from an exhibition by Olafur Eliasson, where a room was illuminated with low-pressure sodium lamps, creating an almost monochromatic yellow light, we compared visual assessments in the yellow room with conventional lighting in a white room. For VA, the results show no significant differences between the two lighting conditions, while for CS, a more nuanced situation is observed. The bias in CS measurements is clinically relevant, and the p-value suggests that further investigation with a larger, more diverse sample may be worthwhile. Despite limitations, such as higher illumination conditions than standard protocols, the unique ``laboratory'' offered by the exhibition facilitated measurements not easily achievable in a traditional setting., Comment: Submitted to Nuovo Cimento, special number for "SIF simposio Optometria": this version is before referee comments

Published
2024

25. Examining the relation between bilingualism and age of symptom onset in frontotemporal dementia.

Author

de Leon, Jessica, Grasso, Stephanie, Allen, Isabel Elaine, Escueta, Danielle P, Vega, Yvette, Eshghavi, Malihe, Watson, Christa, Dronkers, Nina, Gorno-Tempini, Maria Luisa, and Henry, Maya L

Subjects
Linguistics, Biological Psychology, Cognitive and Computational Psychology, Language, Communication and Culture, Psychology, Behavioral and Social Science, Dementia, Brain Disorders, Alzheimer's Disease Related Dementias (ADRD), Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Aphasia, Neurodegenerative, Frontotemporal Dementia (FTD), Aging, Rare Diseases, Basic Behavioral and Social Science, Acquired Cognitive Impairment, Clinical Research, Neurosciences, Alzheimer's Disease, Neurological, frontotemporal dementia, primary progressive aphasia, bilingualism, cognitive reserve, Alzheimer's dementia, Alzheimer’s dementia, Cognitive Sciences, Experimental Psychology, Cognitive and computational psychology
Abstract

Bilingualism is thought to confer advantages in executive functioning, thereby contributing to cognitive reserve and a later age of dementia symptom onset. While the relation between bilingualism and age of onset has been explored in Alzheimer's dementia, there are few studies examining bilingualism as a contributor to cognitive reserve in frontotemporal dementia (FTD). In line with previous findings, we hypothesized that bilinguals with behavioral variant FTD would be older at symptom onset compared to monolinguals, but that no such effect would be found in patients with nonfluent/agrammatic variant primary progressive aphasia (PPA) or semantic variant PPA. Contrary to our hypothesis, we found no significant difference in age at symptom onset between monolingual and bilingual speakers within any of the FTD variants, and there were no notable differences on neuropsychological measures. Overall, our results do not support a protective effect of bilingualism in patients with FTD-spectrum disease in a U.S. based cohort.

Published
2024

26. High-statistics measurement of Collins and Sivers asymmetries for transversely polarised deuterons

Author

Alexeev, G. D., Alexeev, M. G., Alice, C., Amoroso, A., Andrieux, V., Anosov, V., Asatryan, S., Augsten, K., Augustyniak, W., Azevedo, C. D. R., Badelek, B., Barth, J., Beck, R., Beckers, J., Bedfer, Y., Bernhard, J., Bodlak, M., Bradamante, F., Bressan, A., Chang, W. -C., Chatterjee, C., Chiosso, M., Chumakov, A. G., Chung, S. -U., Cicuttin, A., Correia, P. M. M., Crespo, M. L., D'Ago, D., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Delcarro, F., Denisenko, I., Denisov, O. Yu., Donskov, S. V., Doshita, N., Dreisbach, Ch., Dunnweber, W., Dusaev, R. R., Ecker, D., Eremeev, D., Faccioli, P., Faessler, M., Finger, M., Finger jr., M., Fischer, H., Flothner, K. J., Florian, W., Friedrich, J. M., Frolov, V., Ordonez, L. G. Garcia, Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giarra, J., Giordano, D., Grasso, A., Gridin, A., Perdekamp, M. Grosse, Grube, B., Gruner, M., Guskov, A., Haas, P., von Harrach, D., Hoffmann, M., Hoghmrtsyan, A., d'Hose, N., Hsieh, C. -Y., Huber, S., Ishimoto, S., Ivanov, A., Iwata, T., Jary, V., Joosten, R., Kabuss, E., Kaspar, F., Kerbizi, A., Ketzer, B., Khatun, A., Khaustov, G. V., Klasek, T., Klein, F., Koivuniemi, J. H., Kolosov, V. N., Horikawa, K. Kondo, Konorov, I., Konstantinov, V. F., Korzenev, A. Yu., Kotzinian, A. M., Kouznetsov, O. M., Koval, A., Kral, Z., Krinner, F., Kunne, F., Kurek, K., Kurjata, R. P., Kveton, A., Lavickova, K., Levorato, S., Lian, Y. -S., Lichtenstadt, J., Lin, P. -J., Longo, R., Lyubovitskij, V. E., Maggiora, A., Magnon, A., Makke, N., Mallot, G. K., Maltsev, A., Martin, A., Marzec, J., Matousek, J., Matsuda, T., Mattson, G., Pires, C. Menezes, Metzger, F., Meyer, M., Meyer, W., Mikhailov, Yu. V., Mikhasenko, M., Mitrofanov, E., Miura, D., Miyachi, Y., Molina, R., Moretti, A., Movsisyan, A., Nagaytsev, A., Neyret, D., Niemiec, M., Novy, J., Nowak, W. -D., Nukazuka, G., Olshevsky, A. G., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Pekeler, H., Peng, J. -C., Pesek, M., Peshekhonov, D. V., Peskova, M., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Quaresma, M., Quintans, C., Reicherz, G., Riedl, C., Ryabchikov, D. I., Rychter, A., Rymbekova, A., Samoylenko, V. D., Sandacz, A., Sarkar, S., Savin, I. A., Sbrizzai, G., Schmieden, H., Selyunin, A., Sharko, K., Sinha, L., Spulbeck, D., Srnka, A., Stolarski, M., Sulc, M., Suzuki, H., Takanashi, Y., Tessaro, S., Tessarotto, F., Thiel, A., Tosello, F., Townsend, A., Triloki, T., Tskhay, V., Valinoti, B., Veit, B. M., Veloso, J. F. C. A., Ventura, B., Vijayakumar, A., Virius, M., Wagner, M., Wallner, S., Zaremba, K., Zavertyaev, M., Zemko, M., Zemlyanichkina, E., and Ziembicki, M.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

New results are presented on a high-statistics measurement of Collins and Sivers asymmetries of charged hadrons produced in deep inelastic scattering of muons on a transversely polarised $^6$LiD target. The data were taken in 2022 with the COMPASS spectrometer using the 160 \gevv\ muon beam at CERN, balancing the existing data on transversely polarised proton targets. The first results from about two-thirds of the new data have total uncertainties smaller by up to a factor of three compared to the previous deuteron measurements. Using all the COMPASS proton and deuteron results, both the transversity and the Sivers distribution functions of the $u$ and $d$ quark, as well as the tensor charge in the measured $x$-range are extracted. In particular, the accuracy of the $d$ quark results is significantly improved.

Published
2023

27. Final COMPASS results on the transverse-spin-dependent azimuthal asymmetries in the pion-induced Drell-Yan process

Author

Alexeev, G. D., Alexeev, M. G., Alice, C., Amoroso, A., Andrieux, V., Anosov, V., Augsten, K., Augustyniak, W., Azevedo, C. D. R., Badelek, B., Barth, J., Beck, R., Beckers, J., Bedfer, Y., Bernhard, J., Bodlak, M., Bradamante, F., Bressan, A., Chang, W. -C., Chatterjee, C., Chiosso, M., Chumakov, A. G., Chung, S. -U., Cicuttin, A., Correia, P. M. M., Crespo, M. L., D'Ago, D., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Delcarro, F., Denisenko, I., Denisov, O. Yu., Donskov, S. V., Doshita, N., Dreisbach, Ch., Dunnweber, W., Dusaev, R. R., Ecker, D., Eremeev, D., Faccioli, P., Faessler, M., Finger, M., Finger jr., M., Fischer, H., Flothner, K. J., Florian, W., Friedrich, J. M., Frolov, V., Ordonez, L. G. Garcia, Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giarra, J., Giordano, D., Grasso, A., Gridin, A., Perdekamp, M. Grosse, Grube, B., Gruner, M., Guskov, A., Haas, P., von Harrach, D., Heitz, R., Hoffmann, M., d'Hose, N., Hsieh, C. -Y., Huber, S., Ishimoto, S., Ivanov, A., Iwata, T., Jary, V., Joosten, R., Kabuss, E., Kaspar, F., Kerbizi, A., Ketzer, B., Khatun, A., Khaustov, G. V., Klein, F., Koivuniemi, J. H., Kolosov, V. N., Horikawa, K. Kondo, Konorov, I., Konstantinov, V. F., Korzenev, A. Yu., Kotzinian, A. M., Kouznetsov, O. M., Koval, A., Kral, Z., Krinner, F., Kunne, F., Kurek, K., Kurjata, R. P., Kveton, A., Lavickova, K., Levorato, S., Lian, Y. -S., Lichtenstadt, J., Lin, P. -J., Longo, R., Lyubovitskij, V. E., Maggiora, A., Magnon, A., Makke, N., Mallot, G. K., Maltsev, A., Martin, A., Marzec, J., Matousek, J., Matsuda, T., Mattson, G., Pires, C. Menezes, Metzger, F., Meyer, M., Meyer, W., Mikhailov, Yu. V., Mikhasenko, M., Mitrofanov, E., Miura, D., Miyachi, Y., Molina, R., Moretti, A., Nagaytsev, A., Neyret, D., Niemiec, M., Novy, J., Nowak, W. -D., Nukazuka, G., Olshevsky, A. G., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Pekeler, H., Peng, J. -C., Pesek, M., Peshekhonov, D. V., Peskova, M., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Quaresma, M., Quintans, C., Reicherz, G., Riedl, C., Ryabchikov, D. I., Rychter, A., Rymbekova, A., Samoylenko, V. D., Sandacz, A., Sarkar, S., Savada, T., Savin, I. A., Sbrizzai, G., Schmieden, H., Selyunin, A., Sharko, K., Sinha, L., Spulbeck, D., Srnka, A., Stolarski, M., Sulc, M., Suzuki, H., Tessaro, S., Tessarotto, F., Thiel, A., Tosello, F., Townsend, A., Triloki, T., Tskhay, V., Valinoti, B., Veit, B. M., Veloso, J. F. C. A., Ventura, B., Vijayakumar, A., Virius, M., Wagner, M., Wallner, S., Zaremba, K., Zavertyaev, M., Zemko, M., Zemlyanichkina, E., and Ziembicki, M.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

The COMPASS Collaboration performed measurements of the Drell-Yan process in 2015 and 2018 using a 190 GeV/c $\pi^{-}$ beam impinging on a transversely polarised ammonia target. Combining the data of both years, we present final results on the amplitudes of the five azimuthal modulations in the dimuon production cross section. Three of these transverse-spin-dependent azimuthal asymmetries (TSAs) probe the nucleon leading-twist Sivers, transversity, and pretzelosity transverse-momentum dependent (TMD) parton distribution functions (PDFs). The other two are induced by subleading effects. These TSAs provide unique new inputs for the study of the nucleon TMD PDFs and their universality properties. In particular, the Sivers TSA observed in this measurement is consistent with the fundamental QCD prediction of a sign change of naive time-reversal-odd TMD PDFs when comparing the Drell-Yan process with semi-inclusive measurements of deep inelastic scattering. Also, within the context of model predictions, the observed transversity TSA is consistent with the expectation of a sign change for the Boer-Mulders function.

Published
2023

28. Upper endoscopy in elderly patients: a multicentre, cross-sectional study

Author

Zullo, Angelo, De Francesco, Vincenzo, Amato, Arnaldo, Bergna, Irene, Bendia, Emanuele, Giorgini, Giorgia, Buscarini, Elisabetta, Manfredi, Guido, Cadoni, Sergio, Cannizzaro, Renato, Realdon, Stefano, Ciuffi, Mario, Ignomirelli, Orazio, Da Massa Carrara, Paola, Finucci, Giovanni, Di Somma, Antonietta, Frandina, Chiara, Loria, Mariafrancesca, Galeazzi, Francesca, Ferrara, Francesco, Gemme, Carlo, Bertetti, Noemi Sara, Gentili, Federica, Lotito, Antonio, Germanà, Bastianello, Russo, Nunzia, Grande, Giuseppe, Conigliaro, Rita, Cravero, Federico, Venezia, Giovanna, Marmo, Riccardo, Senneca, Piera, Milano, Angelo, Efthymakis, Konstantinos, Monica, Fabio, Montalto, Paolo, Lombardi, Mario, Morelli, Olivia, Castellani, Danilo, Nigro, Daniela, Festa, Roberto, Peralta, Sergio, Grasso, Maria, Privitera, Antonello, Di Stefano, Maria Emanuela, Scaccianoce, Giuseppe, Loiacono, Mariangela, Segato, Sergio, Balzarini, Marco, Satta, Paolo Usai, Lai, Mariantonia, Fortunato, Francesca, and Manta, Raffaele

Published
2024
Full Text
View/download PDF

32. Impact of heart failure severity on the mortality benefit of mitral transcatheter edge-to-edge valve repair

Author

Magni, Valeria, Adamo, Marianna, Pezzola, Elisa, Rubbio, Antonio Popolo, Giannini, Cristina, Masiero, Giulia, Grasso, Carmelo, Denti, Paolo, Giordano, Arturo, De Marco, Federico, Bartorelli, Antonio L., Montorfano, Matteo, Godino, Cosmo, Baldi, Cesare, De Felice, Francesco, Mongiardo, Annalisa, Monteforte, Ida, Villa, Emmanuel, Crimi, Gabriele, Tusa, Maurizio, Testa, Luca, Serafini, Lisa, Cani, Dario, Guarini, Giacinta, Huqi, Alda, Sesana, Marco, De Carlo, Marco, Maisano, Francesco, Tarantini, Giuseppe, Tamburino, Corrado, Bedogni, Francesco, and Metra, Marco

Published
2024
Full Text
View/download PDF

36. Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells

Author

Carrelha, Joana, Mazzi, Stefania, Winroth, Axel, Hagemann-Jensen, Michael, Ziegenhain, Christoph, Högstrand, Kari, Seki, Masafumi, Brennan, Margs S., Lehander, Madeleine, Wu, Bishan, Meng, Yiran, Markljung, Ellen, Norfo, Ruggiero, Ishida, Hisashi, Belander Strålin, Karin, Grasso, Francesca, Simoglou Karali, Christina, Aliouat, Affaf, Hillen, Amy, Chari, Edwin, Siletti, Kimberly, Thongjuea, Supat, Mead, Adam J., Linnarsson, Sten, Nerlov, Claus, Sandberg, Rickard, Yoshizato, Tetsuichi, Woll, Petter S., and Jacobsen, Sten Eirik W.

Published
2024
Full Text
View/download PDF

39. Towards a tailored approach for patients with acute diverticulitis and abscess formation. The DivAbsc2023 multicentre case–control study

Author

Podda, Mauro, Ceresoli, Marco, Di Martino, Marcello, Ortenzi, Monica, Pellino, Gianluca, Pata, Francesco, Ielpo, Benedetto, Murzi, Valentina, Balla, Andrea, Lepiane, Pasquale, Tamini, Nicolo’, De Carlo, Giulia, Davolio, Alessia, Di Saverio, Salomone, Cardinali, Luca, Botteri, Emanuele, Vettoretto, Nereo, Gelera, Pier Paolo, De Simone, Belinda, Grasso, Antonella, Clementi, Marco, Meloni, Danilo, Poillucci, Gaetano, Favi, Francesco, Rizzo, Roberta, Montori, Giulia, Procida, Giuseppa, Recchia, Irene, Agresta, Ferdinando, Virdis, Francesco, Cioffi, Stefano Piero Bernardo, Pellegrini, Martina, Sartelli, Massimo, Coccolini, Federico, Catena, Fausto, and Pisanu, Adolfo

Published
2024
Full Text
View/download PDF

44. An Experiment in Retrofitting Competency Questions for Existing Ontologies

Author

Alharbi, Reham, Tamma, Valentina, Grasso, Floriana, and Payne, Terry

Subjects
Computer Science - Artificial Intelligence
Abstract

Competency Questions (CQs) are a form of ontology functional requirements expressed as natural language questions. Inspecting CQs together with the axioms in an ontology provides critical insights into the intended scope and applicability of the ontology. CQs also underpin a number of tasks in the development of ontologies e.g. ontology reuse, ontology testing, requirement specification, and the definition of patterns that implement such requirements. Although CQs are integral to the majority of ontology engineering methodologies, the practice of publishing CQs alongside the ontological artefacts is not widely observed by the community. In this context, we present an experiment in retrofitting CQs from existing ontologies. We propose RETROFIT-CQs, a method to extract candidate CQs directly from ontologies using Generative AI. In the paper we present the pipeline that facilitates the extraction of CQs by leveraging Large Language Models (LLMs) and we discuss its application to a number of existing ontologies.

Published
2023
Full Text
View/download PDF

45. Galactic Gamma-Ray Diffuse Emission at TeV energies with HAWC Data

Author

Alfaro, R., Alvarez, C., Arteaga-Velazquez, J. C., Arunbabu, K. P., Rojas, D. Avila, Babu, R., Baghmanyan, V., Belmont-Moreno, E., Brisbois, C., Caballero-Mora, K. S., Capistran, T., Carraminana, A., Casanova, S., Chaparro-Amaro, O., Cotti, U., Cotzomi, J., de Leon, S. Coutino, De la Fuente, E., Hernandez, R. Diaz, DuVernois, M. A., Durocher, M., Dıaz-Velez, J. C., Engel, K., Espinoza, C., Fan, K. L., Fraija, N., Galvan-Gamez, A., Garcıa-Gonzalez, J. A., Garfias, F., Gonzalez, M. M., Goodman, J. A., Hernandez, S., Hona, B., Huang, D., Hueyotl-Zahuantitla, F., Humensky, T. B., Iriarte, A., Joshi, V., Kaufmann, S., Kieda, D., Kunde, G. J., Lara, A., Vargas, H. Leon, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Malone, K., Martinez, O., Martınez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Moreno, E., Mostafa, M., Nayerhoda, A., Nellen, L., Noriega-Papaqui, R., Perez-Perez, E. G., Rosa-Gonzalez, D., Ruiz-Velasco, E., Salazar, H., Salazar-Gallegos, D., Greus, F. Salesa, Sandoval, A., Serna-Franco, J., Smith, A. J., Springer, R. W., Tibolla, O., Tollefson, K., Torres, I., Torres-Escobedo, R., Urena-Mena, F., Villasenor, L., Willox, E., Zhou, H., de Leon, C., Fornieri, O., Gaggero, D., Grasso, D., Marinelli, A., and Ventura, S.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Galactic gamma-ray diffuse emission (GDE) is emitted by cosmic rays (CRs), ultra-relativistic protons and electrons, interacting with gas and electromagnetic radiation fields in the interstellar medium. Here we present the analysis of TeV diffuse emission from a region of the Galactic Plane over the range in longitude of $l\in[43^\circ,73^\circ]$, using data collected with the High Altitude Water Cherenkov (HAWC) detector. Spectral, longitudinal and latitudinal distributions of the TeV diffuse emission are shown. The radiation spectrum is compatible with the spectrum of the emission arising from a CR population with an "index" similar to that of the observed CRs. When comparing with the \texttt{DRAGON} \textit{base model}, the HAWC GDE flux is higher by about a factor of two. Unresolved sources such as pulsar wind nebulae and TeV halos could explain the excess emission. Finally, deviations of the Galactic CR flux from the locally measured CR flux may additionally explain the difference between the predicted and measured diffuse fluxes.

Published
2023

46. Chasing Gravitational Waves with the Cherenkov Telescope Array

Author

Green, Jarred Gershon, Carosi, Alessandro, Nava, Lara, Patricelli, Barbara, Schüssler, Fabian, Seglar-Arroyo, Monica, Consortium, Cta, Abe, Kazuki, Abe, Shotaro, Acharyya, Atreya, Adam, Remi, Aguasca-Cabot, Arnau, Agudo, Ivan, Alfaro, Jorge, Alvarez-Crespo, Nuria, Batista, Rafael Alves, Amans, Jean-Philippe, Amato, Elena, Ambrosino, Filippo, Angüner, Ekrem Oguzhan, Antonelli, Lucio Angelo, Aramo, Carla, Arcaro, Cornelia, Arrabito, Luisa, Asano, Katsuaki, Aschersleben, Jann, Ashkar, Halim, Stuani, Luiz Augusto, Baack, Dominik, Backes, Michael, Balazs, Csaba, Balbo, Matteo, Larriva, Andres Baquero, Martins, Victor Barbosa, de Almeida, Ulisses Barres, Barrio, Juan Abel, Bastieri, Denis, Batista, Pedro Ivo, Batković, Ivana, Batzofin, Rowan William, Baxter, Joshua Ryo, Beck, Geoffrey, Tjus, Julia Becker, Beiske, Lukas, Belardinelli, Daniele, Benbow, Wystan, Bernardini, Elisa, Medrano, Juan Bernete, Bernlöhr, Konrad, Berti, Alessio, Beshley, Vasyl, Bhattacharjee, Pooja, Bhattacharyya, Saptashwa, Bi, Baiyang, Biederbeck, Noah, Biland, Adrian, Bissaldi, Elisabetta, Blanch, Oscar, Blazek, Jiri, Boisson, Catherine, Bolmont, Julien, Bonnoli, Giacomo, Bordas, Pol, Bošnjak, Željka, Bradascio, Federica, Braiding, Catherine, Bronzini, Ettore, Brose, Robert, Brown, Anthony M., Brun, Francois, Brunelli, Giulia, Bulgarelli, Andrea, Burelli, Irene, Burmistrov, Leonid, Burton, Michael, Bylund, Tomas, Calisse, Paolo Gherardo, Campoy-Ordaz, Anna, Cantlay, Brandon Khan, Capalbi, Milvia, Caproni, Anderson, Capuzzo-Dolcetta, Roberto, Carlile, Colin, Caroff, Sami, Carosi, Roberto, Carrasco, Marie-Sophie, Cascone, Enrico, Cassol, Franca, Castrejon, Noelia, Catalani, Fernando, Cerasole, Davide, Cerruti, Matteo, Chaty, Sylvain, Chen, Andrew W, Chernyakova, Maria, Chiavassa, Andrea, Chudoba, Jiří, Araujo, Carlos Henrique Coimbra, Conforti, Vito, Conte, Francesco, Contreras, Jose Luis, Cossou, Christophe, Costa, Alessandro, Costantini, Heide, Cristofari, Pierre, Cuevas, Omar, Curtis-Ginsberg, Zachary, D'Amico, Giacomo, D'Ammando, Filippo, Dadina, Mauro, Dalchenko, Mykhailo, David, Ludovic, Davids, Isak Delberth, Dazzi, Francesco, De Angelis, Alessandro, de Lavergne, Mathieu de Bony, De Caprio, Vincenzo, De Cesare, Giovanni, Pino, Elisabete M. de Gouveia Dal, De Lotto, Barbara, de Lucia, Mario, de Menezes, Raniere, de Naurois, Mathieu, Wilhelmi, Emma de Oña, De Simone, Nicola, de Souza, Vitor, Del Peral, Luis, del Valle, Maria Victoria, Delagnes, Eric, Giler, Andres Gabriel Delgado, Delgado, Carlos, Dell'aiera, Michael, Della Ceca, Roberto, Della Valle, Massimo, Della Volpe, Domenico, Depaoli, Davide, Dettlaff, Antonios, Di Girolamo, Tristano, Di Piano, Ambra, Di Pierro, Federico, Di Tria, Riccardo, Di Venere, Leonardo, Díaz-Bahamondes, Christian, Dib, Claudio, Diebold, Sebastian, Dima, Razvan, Dinesh, Adithiya, Djannati-Ataï, Arache, Djuvsland, Julia Isabel, Dominguez, Alberto, Dominik, Rune Michael, Donini, Alice, Dorner, Daniela, Dörner, Julien, Doro, Michele, Anjos, Rita de Cassia dos, Dournaux, Jean-Laurent, Dravins, Dainis, Duangchan, Chaimongkol, Dubos, Coline, Ducci, Lozenzo, Dwarkadas, Vikram V., Ebr, Jan, Eckner, Christopher, Egberts, Kathrin, Einecke, Sabrina, Elsässer, Dominik, Emery, Gabriel, Godoy, Miguel Escobar, Escudero, Juan, Esposito, Paolo, Falceta-Gonçalves, Diego, Ramazani, Vandad Fallah, Faure, Alice, Fedorova, Elena, Fegan, Stephen, Feijen, Kirsty, Feng, Qi, Ferrand, Gilles, Ferrarotto, Fabio, Fiandrini, Emanuele, Fiasson, Armand, Fioretti, Valentina, Foffano, Luca, Guiteras, Lluis Font, Fontaine, Gerard, Fröse, Stefan, Fukami, Satoshi, Fukui, Yasuo, Funk, Stefan, Gaggero, Daniele, Galanti, Giorgio, Galaz, Gaspar, Gallant, Yves A., Gallozzi, Stefano, Gammaldi, Viviana, Gasbarra, Claudio, Gaug, Markus, Ghalumyan, Arsen, Gianotti, Fulvio, Giarrusso, Marina, Giglietto, Nicola, Giordano, Francesco, Giuliani, Andrea, Glicenstein, Jean-Francois, Glombitza, Jonas, Goldoni, Paolo, González, José Mauricio, González, Maria Magdalena, Coelho, Jaziel Goulart, Granot, Jonathan, Grasso, Dario, Haro, Roger Grau, Green, David, Greenshaw, Tim, Grolleron, Guillaume, Grube, Jeff, Gueta, Orel, Gunji, Shuichi, Hadasch, Daniela, Hamal, Petr, Hanlon, William, Hara, Satoshi, Harvey, Violet M., Hashiyama, Kazuaki, Hassan, Tarek, Heller, Matthieu, Cadena, Sergio Hernández, Hie, Jonathan, Hiroshima, Nagisa, Hnatyk, Bohdan, Hnatyk, Roman, Hoffmann, Dirk, Hofmann, Werner, Holler, Markus, Horan, Deirdre, Horvath, Pavel, Hovatta, Talvikki, Hrupec, Dario, Hussain, Saqib, Iarlori, Marco, Inada, Tomohiro, Incardona, Federico, Inome, Yusuke, Inoue, Susumu, Iocco, Fabio, Ishio, Kazuma, Jamrozy, Marek, Janecek, Petr, Jankowsky, Felix, Jarnot, Christian, Jean, Pierre, Martínez, Irene Jiménez, Jin, Weidong, Jocou, Laurent, Juramy-Gilles, Claire, Jurysek, Jakub, KALEKIN, Oleg, Kantzas, Dimitrios, Karas, Vladimir, Kaufmann, Sarah, Kerszberg, Daniel, Khelifi, Bruno, Kieda, David B, Kleiner, Tobias Kai, Kluźniak, Włodzimierz, Kobayashi, Yukiho, Kohri, Kazunori, Komin, Nukri, Kornecki, Paula, Kosack, Karl, Kubo, Hidetoshi, Kushida, Junko, La Barbera, Antonino, La Palombara, Nicola, Lainez, Maria, Lamastra, Alessandra, Lapington, Jon S, Lazarevic, Sanja, Lazendic-Galloway, Jasmina, Leach, Steven, Lemoine-Goumard, Marianne, Lenain, Jean-Philippe, Leto, Giuseppe, Leuschner, Fabian, Lindfors, Elina, Linhoff, Maximilian, Liodakis, Ioannis, Loïc, Lozach, Lombardi, Saverio, Longo, Francesco, López-Coto, Rubén, López-Moya, Marcos, López-Oramas, Alicia, Loporchio, Serena, Bahilo, Julio Lozano, Luque-Escamilla, Pedro L., Macias, Oscar, Maier, Gernot, Majumdar, Pratik, Malyshev, Denys, Malyshev, Dmitry, Mandat, Dusan, Manicò, Giulio, Marinos, Peter David, Markoff, Sera, Márquez, Isabel, Marquez, Patricia, Marsella, Giovanni, Martí, Josep, Martin, Pierrick, Martínez, Gustavo Augusto, Martínez, Manel, Martinez, Oibar, Marty, Christophe, Mas-Aguilar, Alvaro, Mastropietro, Michele, Maurin, Gilles, Max-Moerbeck, Walter, Mazin, Daniel, Melkumyan, David, Menchiari, Stefano, Mestre, Enrique, Meunier, Jean-Luc, Meyer, Dominique M. -A., Miceli, Davide, Michailidis, Miltiadis, Michałowski, Jerzy, Miener, Tjark, Miranda, Jose Miguel, Mitchell, Alison, Mizote, Masaya, Mizuno, Tsunefumi, Moderski, Rafal, Mohrmann, Lars, Molero, Miguel, Molfese, Cesare, Molina, Edgar, Montaruli, Teresa, Moralejo, Abelardo, Morcuende, Daniel, Morik, Katharina, Morselli, Aldo, Moulin, Emmanuel, Zamanillo, Victor Moya, Mukherjee, Reshmi, Munari, Kevin, Muraczewski, Adam, Muraishi, Hiroshi, Nakamori, Takeshi, Nayak, Amrit, Nemmen, Rodrigo, Nickel, Lukas, Niemiec, Jacek, Nieto, Daniel, Rosillo, Mireia Nievas, Nikołajuk, Marek, Nishijima, Kyoshi, Noda, Koji, Nosek, Dalibor, Novosyadlyj, Bohdan, Novotný, Vladimír, Nozaki, Seiya, O'Brien, Paul, Ohishi, Michiko, Ohtani, Yoshiki, Okumura, Akira, Olive, Jean-François, Olmi, Barbara, Ong, Rene A., Orienti, Monica, Orito, Reiko, Orlandini, Mauro, Orlando, Elena, Ostrowski, Michal, Otte, Nepomuk, Oya, Igor, Pagano, Isabella, Pagliaro, Antonio, Palatiello, Michele, Panebianco, Gabriele, Paredes, Josep M., Parmiggiani, Nicolò, Patel, Sonal Ramesh, Pavlović, Dijana, Pe'er, Asaf, Pech, Miroslav, Pecimotika, Mario, Peresano, Michele, Pérez-Romero, Judit, Peron, Giada, Persic, Massimo, Petrucci, Pierre-Olivier, Petruk, Oleh, Pfeifle, Felix, Pintore, Fabio, Pirola, Giorgio, Pittori, Carlotta, Plard, Cyann, Podobnik, Franjo, Pohl, Martin, Pons, Estelle, Prandini, Elisa, Prast, Julie, Principe, Giacomo, Priyadarshi, Chaitanya, Produit, Nicolas, Prokhorov, Dmitry, Pueschel, Elisa, Pühlhofer, Gerd, Pumo, Maria Letizia, Punch, Michael, Quirrenbach, Andreas, Raino, Silvia, Randazzo, Nunzio, Rando, Riccardo, Ravel, Thierry, Razzaque, Soebur, Regeard, Maxime, Reichherzer, Patrick, Reimer, Anita, Reimer, Olaf, Reisenegger, Andreas, Reposeur, Thierry, Reville, Brian, Rhode, Wolfgang, Ribó, Marc, Richtler, Tom, Rieger, Frank, Roache, Emmet, Fernandez, Gonzalo Rodriguez, Frías, Maria Dolores Rodríguez, Rodríguez-Vázquez, Juan José, Romano, Patrizia, Romeo, Giuseppe, Rosado, Jaime, Rowell, Gavin P, Rudak, Bronislaw, Ruiter, Ashley J., Rulten, Cameron Boyd, Russo, Federico, Sadeh, Iftach, Saha, Lab, Saito, Takayuki, Sakurai, Shunsuke, Salzmann, Heiko, Sanchez, David, Sanchez-Conde, Miguel, Sangiorgi, Pierluca, Sano, Hidetoshi, Santander, Marcos, Santangelo, Andrea, Santos-Lima, Reinaldo, Sanuy, Andreu, Šarić, Toni, Sarkar, Arkadipta, Sarkar, Subir, Saturni, Francesco Gabriele, Savchenko, Volodymyr, Scherer, Andres, Schipani, Pietro, Schleicher, Bernd, Schovanek, Petr, Schubert, Jan Lukas, Schwanke, Ullrich, Schwefer, Georg, Scuderi, Salvatore, Arroyo, Monica Seglar, Seitenzahl, Ivo, Sergijenko, Olga, Sguera, Vito, Shang, Ruo-Yu, Sharma, Pooja, Sidibe, Guereguin Der Sylvestre, Sidoli, Lara, Siejkowski, Hubert, Siqueira, Clarissa, Sizun, Patrick, Sliusar, Vitalii, Slowikowska, Agnieszka, Sol, Helene, Specovius, Andreas, Spencer, Samuel Timothy, Spiga, Daniele, Stamerra, Antonio, Stanič, Samo, Starecki, Tomasz, Starling, Rhaana, Steppa, Constantin, Stolarczyk, Thierry, Strišković, Jelena, Strzys, Marcel C., Suda, Yusuke, Suomijarvi, Tiina, Tak, Donggeun, Takahashi, Mitsunari, Takeishi, Ryuji, Tam, Pak-Hin Thomas, Tanaka, Shuta J, Tanaka, Takaaki, Terauchi, Kenta, Testa, Vincenzo, Tibaldo, Luigi, Tibolla, Omar, Torradeflot, Francesc, Torres, Diego F., Torresi, Eleonora, Tothill, Nick, Toussenel, Francois, Touzard, Victoria, Tramacere, Andrea, Travnicek, Petr, Tripodo, Giovanni, Truzzi, Stefano, Tsiahina, Adellain, Tutone, Antonio, Vacula, Martin, Vallage, Bertrand, Vallania, Piero, Vallés, Ramon, van Eldik, Christopher, van Scherpenberg, Juliane, Vandenbroucke, Justin, Vassiliev, Vladimir, Venault, Philippe, Ventura, Sofia, Vercellone, Stefano, Verna, Gaia, Viana, Aion, Viaux, Nicolás, Vigliano, Alessandro, Vignatti, Jonatan, Vigorito, Carlo francesco, Vitale, Vincenzo, Vodeb, Veronika, Voisin, Vincent, Vorobiov, Serguei, Voutsinas, Georgios Gerasimos, Vovk, Ievgen, Waegebaert, Vincent, Wagner, Stefan Joachim, Walter, Roland, Ward, Martin, Wechakama, Maneenate, White, Richard, Wierzcholska, Alicja, Will, Martin, Williams, David A., Wohlleben, Frederik, Wolter, Anna, Yamamoto, Tokonatsu, Yamazaki, Ryo, Yang, Lili, Yoshida, Tatsuo, Yoshikoshi, Takanori, Zacharias, Michael, Sanchez, Ricardo Zanmar, Zavrtanik, Danilo, Zavrtanik, Marko, Zdziarski, Andrzej A., Zech, Andreas, Zhdanov, Valery I., Ziȩtara, Krzysztof, Živec, Miha, and Zuriaga-Puig, Jaume

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The detection of gravitational waves from a binary neutron star merger by Advanced LIGO and Advanced Virgo (GW170817), along with the discovery of the electromagnetic counterparts of this gravitational wave event, ushered in a new era of multimessenger astronomy, providing the first direct evidence that BNS mergers are progenitors of short gamma-ray bursts (GRBs). Such events may also produce very-high-energy (VHE, > 100GeV) photons which have yet to be detected in coincidence with a gravitational wave signal. The Cherenkov Telescope Array (CTA) is a next-generation VHE observatory which aims to be indispensable in this search, with an unparalleled sensitivity and ability to slew anywhere on the sky within a few tens of seconds. New observing modes and follow-up strategies are being developed for CTA to rapidly cover localization areas of gravitational wave events that are typically larger than the CTA field of view. This work will evaluate and provide estimations on the expected number of of gravitational wave events that will be observable with CTA, considering both on- and off-axis emission. In addition, we will present and discuss the prospects of potential follow-up strategies with CTA., Comment: Presented at the 38th International Cosmic Ray Conference (ICRC 2023), 2023 (arXiv:2309.08219)

Published
2023

47. Post disruption reconnection event driven by a runaway current

Author

Singh, L., Borgogno, D., Subba, F., and Grasso, D.

Subjects
Physics - Plasma Physics
Abstract

The role of a runaway current in a post disruption plasma is investigated through numerical simulations in an asymmetric magnetic reconnection event. While the runaways do not alter the linear growth of the island, they lead to a rotation of the island in the poloidal direction as found in [C. Liu et al. Physics of Plasmas 27, 092507 (2020)]. The role of a microlayer smaller than the resistive one is thoroughly investigated. While the resistive layer controls the transition of the island from the linear to the nonlinear stage, the microlayer width causes the runaways to become nonlinear as soon as the size of the island exceeds it. Moreover, this transition of the runways electrons to the nonlinear phase is accompanied by a drastic redistribution of runaways within the island with respect to the symmetric case. The influence of the electron skin depth on the linear evolution is also taken into account. Finally, nonlinear simulations show that the rotation frequency tends toward zero when the island saturates.

Published
2023

48. Correction to: Psychosocial factors associated with quality of life in cancer survivors: umbrella review

Author

Voskanyan, Viktorya, Marzorati, Chiara, Sala, Diana, Grasso, Roberto, Pietrobon, Ricardo, van der Heide, Iris, Engelaar, Merel, Bos, Nanne, Caraceni, Augusto, Couspel, Norbert, Ferrer, Montse, Groenvold, Mogens, Kaasa, Stein, Lombardo, Claudio, Sirven, Aude, Vachon, Hugo, Velikova, Galina, Brunelli, Cinzia, Apolone, Giovanni, and Pravettoni, Gabriella

Published
2024
Full Text
View/download PDF

49. Hospital Readmissions Among Persons With Human Immunodeficiency Virus in the United States and Canada, 2005–2018: A Collaboration of Cohort Studies

Author

Davy-Mendez, Thibaut, Napravnik, Sonia, Hogan, Brenna C, Eron, Joseph J, Gebo, Kelly A, Althoff, Keri N, Moore, Richard D, Silverberg, Michael J, Horberg, Michael A, Gill, M John, Rebeiro, Peter F, Karris, Maile Y, Klein, Marina B, Kitahata, Mari M, Crane, Heidi M, Nijhawan, Ank, McGinnis, Kathleen A, Thorne, Jennifer E, Lima, Viviane D, Bosch, Ronald J, Colasanti, Jonathan A, Rabkin, Charles S, Lang, Raynell, Berry, Stephen A, Benson, Constance A, Kirk, Gregory D, Greenberg, Alan E, Castel, Amanda D, Monroe, Anne K, Marconi, Vincent, Colasanti, Jonathan, Mayer, Kenneth H, Grasso, Chris, Hogg, Robert S, Montaner, Julio SG, Salters, Kate, Buchacz, Kate, Li, Jun, Jacobson, Jeffrey, Brown, Todd, Tien, Phyllis, D'Souza, Gypsyamber, Smith, Graham, Loutfy, Mona, Gupta, Meenakshi, Rabkin, Charles, Kroch, Abigail, Burchell, Ann, Betts, Adrian, Lindsay, Joanne, Mayor, Angel M, Martin, Jeffrey N, Deeks, Steven G, Brooks, John T, Saag, Michael S, Mugavero, Michael J, Burkholder, Greer, Bamford, Laura, Karris, Maile, Sterling, Timothy R, Haas, David, Rebeiro, Peter, Turner, Megan, McGinnis, Kathleen, Justice, Amy, Gange, Stephen J, Lee, Jennifer S, Hogan, Brenna, Humes, Elizabeth, Coburn, Sally, Gerace, Lucas, and Stewart, Cameron

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Good Health and Well Being, Adult, Male, Humans, United States, Patient Readmission, HIV, HIV Infections, Cohort Studies, Canada, aging, healthcare utilization, hospitalization, readmission, North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of the International epidemiology Databases to Evaluate AIDS, Biological Sciences, Medical and Health Sciences, Microbiology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundHospital readmission trends for persons with human immunodeficiency virus (PWH) in North America in the context of policy changes, improved antiretroviral therapy (ART), and aging are not well-known. We examined readmissions during 2005-2018 among adult PWH in NA-ACCORD.MethodsLinear risk regression estimated calendar trends in 30-day readmissions, adjusted for demographics, CD4 count, AIDS history, virologic suppression (

Published
2023

50. Reintroduction of resistant frogs facilitates landscape-scale recovery in the presence of a lethal fungal disease

Author

Roland A. Knapp, Mark Q. Wilber, Maxwell B. Joseph, Thomas C. Smith, and Robert L. Grasso

Subjects
Science
Abstract

Abstract Vast alteration of the biosphere by humans is causing a sixth mass extinction, driven in part by an increase in infectious diseases. The emergence of the lethal fungal pathogen Batrachochytrium dendrobatidis (Bd) has devastated global amphibian biodiversity. Given the lack of any broadly applicable methods to reverse these impacts, the future of many amphibians appears grim. The Sierra Nevada yellow-legged frog (Rana sierrae) is highly susceptible to Bd infection and most R. sierrae populations are extirpated following disease outbreaks. However, some populations persist and eventually recover, and frogs in these recovering populations have increased resistance against infection. Here, we conduct a 15-year reintroduction study and show that frogs collected from recovering populations and reintroduced to vacant habitats can reestablish populations despite the presence of Bd. In addition, the likelihood of establishment is influenced by site, cohort, and frog attributes. Results from viability modeling suggest that many reintroduced populations have a low probability of extinction over 50 years. These results provide a rare example of how reintroduction of resistant individuals can allow the landscape-scale recovery of disease-impacted species, and have broad implications for amphibians and other taxa that are threatened with extinction by novel pathogens.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results