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1. COVID-19 SEVERITY PREDICTION BASED ON RADIOMIC FEATURES EXTRACTED FROM LUNG CT SCANS USING THE LUNGQUANT SEGMENTATION SOFTWARE

Author

Scapicchio, C., primary, Ballante, E., additional, Benfante, A., additional, Berta, L., additional, Bortolotto, C., additional, Brero, F., additional, Cabini, R.F., additional, Chincarini, A., additional, Cicolari, D., additional, Colombo, P.E., additional, Fanni, S.C., additional, Fantacci, M.E., additional, Figini, S., additional, Grassedonio, E., additional, La Fiura, A., additional, Lascialfari, A., additional, Lenardi, C., additional, Lionetti, A., additional, Lizzi, F., additional, Marrale, M., additional, Nardi, C., additional, Neri, E., additional, Postuma, I., additional, Preda, L., additional, Rizzetto, F., additional, Scichilone, N., additional, Spina, N., additional, Talamonti, C., additional, Torresin, A., additional, Ubaldi, L., additional, Vanzulli, A., additional, Zorzi, G., additional, and Retico, A., additional

Published
2023
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2. Machine learning classification for COVID19 patients performed on small datasets of CT scans

Author

Marrale Maurizio, La Fiura A, Collura G, D’Oca Maria Cristina, Lizzi F, Brero F, Cabini RF, Postuma I, Rinaldi L, Scapicchio C, Castiglioni I, Cristofalo G, Grassedonio E, Galia G M, Scichilone N, Retico A, B. Alzani, M. Bellacosa e G. Bianchi Bazzi, Marrale Maurizio, La Fiura A, Collura G, D’Oca Maria Cristina, Lizzi F, Brero F, Cabini RF, Postuma I, Rinaldi L, Scapicchio C, Castiglioni I, Cristofalo G, Grassedonio E, Galia G M, Scichilone N, and Retico A

Subjects
COVID19, CT scans, medical artificial intelligence AI, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Abstract

In this work we evaluated the possibility of carrying out classifications of the outcome of patients with COVID19 disease through machine learning (ML) techniques working on small datasets of computed tomography (CT) images. In fact, one of the most common problems for medical artificial intelligence (AI) applications is the limited availability of annotated clinical data for model training. In the framework of the artificial intelligence in medicine (AIM) project funded by INFN, we analyzed datasets of CT scans of 79 subjects combined with clinical data containing information relating to positive outcome (no need for intensive care) or poor prognosis (admission into intensive care unit and/or death). After segmentation of ground glass opacities related to this pathology, the radiomic features were subsequently extracted from the CTs, selected through various algorithms of dimension reduction or fea ture selection and used for the training various classifiers. Values of the area under the ROC curve (AUC) of 0.84 were obtained with Gradient Boosting after BORUTA feature selection. Features selected are related to disease characteristics of poor prognosis patients.

Published
2022

3. MO-11.4 - COVID-19 SEVERITY PREDICTION BASED ON RADIOMIC FEATURES EXTRACTED FROM LUNG CT SCANS USING THE LUNGQUANT SEGMENTATION SOFTWARE

Author

Scapicchio, C., Ballante, E., Benfante, A., Berta, L., Bortolotto, C., Brero, F., Cabini, R.F., Chincarini, A., Cicolari, D., Colombo, P.E., Fanni, S.C., Fantacci, M.E., Figini, S., Grassedonio, E., La Fiura, A., Lascialfari, A., Lenardi, C., Lionetti, A., Lizzi, F., Marrale, M., Nardi, C., Neri, E., Postuma, I., Preda, L., Rizzetto, F., Scichilone, N., Spina, N., Talamonti, C., Torresin, A., Ubaldi, L., Vanzulli, A., Zorzi, G., and Retico, A.

Published
2023
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4. [From evidence to care sustainability: risk management by contrast agent in cancer patient. Experience in an italian teaching hospital]

Author

Grassedonio, E, Incorvaia, L, Guarneri, M, Giubbini, Gabriele, De Belvis, Antonio, Midiri, M, Giubbini, G, de Belvis, A (ORCID:0000-0003-4456-1937), Grassedonio, E, Incorvaia, L, Guarneri, M, Giubbini, Gabriele, De Belvis, Antonio, Midiri, M, Giubbini, G, and de Belvis, A (ORCID:0000-0003-4456-1937)

Abstract

The use of organo-iodinated contrast media (CM) in diagnostics and intervention has increased in the last 10 years. It is necessary to distinguish between the different types of contrast agent, primarily with respect to osmolarity: with low osmolarity the safety profile for the patient is higher. The risk of acute renal injury caused by contrast agent (PC-AKI) is however determined also by risk factors related to the patient. Particularly in main centers, it is advisable to have a standardized program in order to stratify patients with respect to risk, to define prevention strategies and the roles of the specialists involved. The experience described in this work consists in the application of an organizational model relating to CT, with a feasibility study of applying an evidence-based check-list in the clinical routine, as a tool to support clinical decisions (Clinical Decision Support System, CDSS) in the oncology field. A pilot evaluation was carried out on 54 patients belonging to the case series treated in a Teaching Hospital, in a day service regime with a diagnosis of solid tumor. The results of this evaluation led the working group to believe that the CDSS thus structured determines the possibility of overestimating the clinical risk of PC-AKI, and consequently to redefine the evaluation form. Experience has shown that it is not generally easy to immediately identify an algorithm useful for standardizing the management of clinically complex situations, such as PC-AKI prevention. The conduction of pilot evaluations can be a valid instrument of harmonization between the solidity of the references deriving from evidence based medicine and the tangibility of real world data. It is advisable to broaden the application of the CDSS more in a larger number of cases, as well as conduct a pre-post analysis relating to the clinical impact in terms of incidence from PC-AKI.

Published
2022

7. Pancreaticoduodenal arteries aneurysms: Evaluation of frequency and association with celiac artery stenosis due to compression by median arcuate ligament

Author

Caruana G., Cannella R., Giambelluca D., Picone D., Lo Re G., Grassedonio E., Midiri M., Salvaggio G., Caruana G., Cannella R., Giambelluca D., Picone D., Lo Re G., Grassedonio E., Midiri M., and Salvaggio G.

Subjects
Superior mesenteric artery, Median arcuate ligament syndrome, Celiac artery, Computed tomography angiography, Aneurysm
Abstract

The aim of the study is to evaluate the prevalence of pancreaticoduodenal arteries (PDA) aneurysms in a large population, and to define possible correlations with celiac artery stenosis due to compression by the median arcuate ligament. Radiological reports of abdominal contrast-enhanced CT scans of 18,180 patients were scrutinized to identify patients with true PDA aneurysms. Two abdominal radiologists classified the aneurysms according to size, location and morphology and scored the presence of celiac artery stenosis due to either median arcuate ligament compression or atherosclerotic disease. Eleven true PDA aneurysms were identified in 10 patients. Nine out of 10 patients had stenosis of the celiac artery, in which 8 cases (80%) was due to compression by the median arcuate ligament of the diaphragm, which likely represents the most common underlying etiology. In our population, the prevalence of reported PDA aneurysms was 0.055.

Published
2019

8. Longitudinal Prospective MRI Study in Pediatric Patients With Thalassemia Major

Author

CASALE, Maddalena, Meloni, A., Filosa, A., Pistoia, L., Sorrentino, F., Quarta, A., Carollo, A., Cirotto, M. C., Positano, V., Grassedonio, E., Missere, M., Pepe, A., Casale, Maddalena, Meloni, A., Filosa, A., Pistoia, L., Sorrentino, F., Quarta, A., Carollo, A., Cirotto, M. C., Positano, V., Grassedonio, E., Missere, M., and Pepe, A.

Published
2017

9. Whole-body diffusion weighted MR and FDG-PET/CT in Hodgkin lymphoma: predictive role before treatment and early assessment aftrer two courses of chemotheraphy

Author

Albano, D., Patti, C., la grutta, L., Matranga, D., Grassedonio, E., Ortolano, C., Midiri, M., Lagalla, R., Galia, M., albano, d, patti, c, la grutta, l, matranga,d, grassedonio, e, ortolano, c, midiri, m, lagalla, r, and galia, m

Subjects
Settore MED/36 - Diagnostica Per Immagini E Radioterapia, lymphoma, MR-Diffusion/Perfusion, PET-CT
Abstract

To evaluate whether whole-body MR has a predictive role before treatment and may asses the response after two courses of chemotherapy in comparison to FDG-PET/CT

Published
2017

12. PF786 REDUCTION OF CARDIAC OUTCOMES IN THALASSEMIA MAJOR THANKS TO A TEN-YEAR NATIONAL ITALIAN NETWORKING

Author

Meloni, A., primary, Pistoia, L., additional, Bisconte, M.G., additional, Ciancio, A., additional, Quarta, A., additional, Cosmi, C., additional, Maddaloni, D., additional, Romano, N., additional, Sorrentino, F., additional, Carrà, A., additional, Schicchi, N., additional, Grassedonio, E., additional, Positano, V., additional, and Pepe, A., additional

Published
2019
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13. P.05.24 WHAT DOES A ILEOCOLONIC WALL THICKENING MEAN? RESULTS FROM A RETROSPECTIVE STUDY

Author

Sinagra, E., primary, Albano, D., additional, Maida, M., additional, Linea, C., additional, Amvrosiadis, G., additional, Rossi, F., additional, Pellegrino, S., additional, Purpura, P., additional, Grassedonio, E., additional, Marasà, M., additional, Testai, S., additional, Bova, V., additional, Galia, M., additional, Lagalla, R., additional, Midiri, F., additional, Midiri, M., additional, Albano, G., additional, and Raimondo, D., additional

Published
2019
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15. [Coronary artery ectasia: etiopathogenesis, diagnosis and treatment]

Author

DENDRAMIS, Gregory, Paleologo, C, Lo Presti, A, Piraino, D, Lo Greco, V, Grassedonio, E, LA GRUTTA, Ludovico, MIDIRI, Massimo, ASSENNATO, Pasquale, NOVO, Salvatore, Dendramis, G, Paleologo, C, Lo Presti, A, Piraino, D, Lo Greco, V, Grassedonio, E, La Grutta, L, Midiri, M, Assennato, P, and Novo S

Subjects
Matrix metalloproteinases, Etiology, Atherosclerosi, Coronary artery ectasia, Humans, Coronary Artery Disease, Settore MED/36 - Diagnostica Per Immagini E Radioterapia, Settore MED/11 - Malattie Dell'Apparato Cardiovascolare, Dilatation, Pathologic
Abstract

Coronary ectasia is a dilation of coronary arteries, angiographically defined if the diameter of the artery is ≥ 1.5 times greater than that of the intact adjacent vascular segment. An association has been found between coronary artery ectasia and a broad spectrum of different diseases, first of all atherosclerotic coronary artery disease. The mechanisms that determine the abnormal dilatation of the vascular lumen and the etiology of coronary artery ectasia are still poorly understood. Various hypotheses have been formulated over the time, the most accredited between these recognizes as main responsible an uncontrolled activity of a particular family of enzymes that degrade the extracellular matrix, the metalloproteinases. This exaggerated activity can be due to an increase in the absolute sense of these enzymes and/or a reduction in the levels of their natural specific inhibitors. Coronary ectasia may have a variable clinical presentation. It is often an occasional finding detected at coronary angiography or following the occurrence of atypical chest pain, stable angina or even acute coronary syndrome. The frequent coexistence of coronary artery ectasia and atherosclerotic coronary artery disease and their common histopathological features have led to hypothesize that coronary ectasia may represent a variant of atherosclerosis. However, some significant differences between these two diseases leave open the hypothesis that coronary artery ectasia may be a pathological entity per se.

Published
2014

16. Remodeled ostial atherosclerotic plaque in a single coronary artery demonstrated by computed tomography coronary angiography

Author

La Grutta, L., Toia, P., Grassedonio, E., Novo, G., Midiri, F., Novo, S., Filippo Cademartiri, Midiri, M., La Grutta, L, Toia, P, Grassedonio, E, Novo, G, Midiri, F, Novo, S, Cademartiri, F, Midiri, M, and Radiology & Nuclear Medicine

Subjects
coronary artery, computed tomography, Settore MED/36 - Diagnostica Per Immagini E Radioterapia, Settore MED/11 - Malattie Dell'Apparato Cardiovascolare
Published
2014

19. Imaging dell'emottisi non traumatica mediante TC Multistrato

Author

LA GRUTTA, Ludovico, GALIA, Massimo, MIDIRI, Massimo, Toia, P, Grassedonio, E, Lo Re, G, La Grutta, L, Toia, P, Grassedonio, E, Lo Re, G, Galia, M, and Midiri, M

Subjects
emottisi, TC Multistrato, Settore MED/36 - Diagnostica Per Immagini E Radioterapia
Published
2014

23. Cuore e grossi vasi (Studio con RM)

Author

Pepe, A, Cracolici, E, Galia, M, Lo Re, G, La Grutta, L, Grassedonio, E, Lombardi, M, Fattori, R, Midiri, M, Lentini, A, Golfieri, R, Pepe, A, Cracolici, E, Galia, M, Lo Re, G, La Grutta, L, Grassedonio, E, Lombardi, M, Fattori, R, and Midiri, M

Subjects
RM cuore, Settore MED/36 - Diagnostica Per Immagini E Radioterapia
Abstract

RM heart

Published
2012

24. Quantification of epicardial adipose tissue in coronary calcium score and CT coronary angiography image data sets: Comparison of attenuation values, thickness and volumes

Author

Grutta, L. (Ludovico) la, Toia, P. (Patrizia), Farruggia, A. (Alfonso), Albano, D. (Domenico), Grassedonio, E. (Emanuele), Palmeri, A. (Antonella), Maffei, E. (Erica), Galia, M. (Massimo), Vitabile, S. (Salvatore), Cademartiri, F. (Filippo), Midiri, M. (Massimo), Grutta, L. (Ludovico) la, Toia, P. (Patrizia), Farruggia, A. (Alfonso), Albano, D. (Domenico), Grassedonio, E. (Emanuele), Palmeri, A. (Antonella), Maffei, E. (Erica), Galia, M. (Massimo), Vitabile, S. (Salvatore), Cademartiri, F. (Filippo), and Midiri, M. (Massimo)

Abstract

Objective: The aim of the study was to compare epicardial adipose tissue (EAT) characteristics assessed with coronary calcium score (CS) and CT coronary angiography (CTCA) image data sets. Methods: In 76 patients (mean age 59613 years) who underwent CS and CTCA owing to suspected coronary artery disease (CAD), EAT was quantified in terms of density (Hounsfield units), thickness and volume. The EAT volume was extracted with a semi-automatic software. Results: A moderate correlation was found between EAT density in CS and CTCA image data sets (2100619HU vs 270624 HU; p,0.05, r50.55). The distribution of EAT was not symmetrical with a maximal thickness at the right atrioventricular groove (14.265.3mm in CS, 15.765mm in CTCA; p.0.05, r50.76). The EAT volume resulted as 122650cm3 in CS and 86640cm3 in CTCA (D530%, p,0.05, r50.92). After adjustment for post-contrast EAT attenuation difference (D530 HU), the volume was 101647cm3 (D517%, p,0.05, r50.92). Based on EAT volume median values, no differences were found between groups with smaller and larger volumes in terms of Agatston score and CAD severity. Conclusion: CS and CTCA image data sets may be equally employed for EAT assessment; however, an underestimation of volume is found with the latter acquisition even after post-contrast attenuation adjustment.

Published
2016
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25. Magnetic resonance in isolated noncompaction of the ventricular myocardium

Author

Fazio, G, D’Angelo, L, Visconti, C, SUTERA, Loredana, Grassedonio, E, Galia, M, Ferrara, F, NOVO, Giuseppina, MIDIRI, Massimo, NOVO, Salvatore, GRASSEDONIO, Emanuele, Fazio, G, Novo, G, D’Angelo, L, Visconti, C, Sutera, L, Grassedonio, E, Galia, M, Ferrara, F, Midiri, M, and Novo, S

Subjects
medicine.medical_specialty, education.field_of_study, medicine.diagnostic_test, business.industry, Population, Diastole, Magnetic resonance imaging, Resonance, myocardium, Settore MED/11 - Malattie Dell'Apparato Cardiovascolare, Apex (geometry), Ventricular myocardium, medicine.anatomical_structure, Ventricle, Non-compaction of the ventricular myocardium (LCVM), Internal medicine, cardiovascular system, Left ventricular myocardium, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business, education, Gradient echo, Cardiovascular magnetic resonance (CMR)
Abstract

Non-compaction of the ventricular myocardium (LCVM) is a rare disorder of myocardial morphogenesis usually diagnosed in paediatric age. The diagnosis was echocardiographically made on the basis of a reported spongeous/compacted ratio >2 in one or more segments of the left ventricle during the diastolic period. We aimed to test the diagnostic accuracy of cardiovascular magnetic resonance (CMR) imaging in distinguishing pathological left ventricular non-compaction. Methods We collected a consecutive series of 8 patients, 5 males and 3 females, with a mean age of 14.9 years with non-compaction of left ventricular myocardium. All patients were admitted in our divisions of cardiology. In all cases the diagnosis was performed by echocardiography. The diagnosis was obtained when the spongeous/compacted ratio was >2 in one or more segments of left ventricle, evaluated in systolic and diastolic period. In the end we completed the diagnosis by scanning with a Signa HD 1.5 T (GE, Milwaukee, USA) the same 8 patients affected by non compaction of ventricular myocardium. In all patients cardiac-gated T1 and T2 black-blood FSE images in short axis and in four-chamber horizontal long axis were obtained. Breath hold cine MR sequences (FIESTA) were performed, covering the whole left ventricle in short-axis plane and in four-chamber view. A segmented inversion-recovery fast gradient echo sequence (IR-FGE) was performed in the short-axis plane of the LV and in four-chamber-view after Gadolinium injection in 8 patients affected by non compaction of left ventricle. At the end of examination the spongeous/compacted ratio >2 was calculated in all involved segments of the left ventricle in diastole. Results In all cases we demonstrated by echocardiography an involvement of the ventricular apex. In 3 cases the structural alterations involved also lateral wall of left ventricle. Magnetic resonance evaluation showed that involvement demonstrated by the echocardiogram was the same: ventricular apex involved in every patient, lateral wall in 3 and all segments in 2. However the spongeous/compacted ratio was >>2 in all patients, with a mean value of 3,1. Conclusions Although our data refer to a small population of patients and need further confirmation, they suggest that it seems reasonable increase the cut-off for spongeous/compacted ratio from a value of 2 to 2.5 for non-compaction diagnosis when high-resolution magnetic resonance is used.

Published
2010

26. Ectasia delle arterie coronarie: eziopatogenesi, diagnosi e trattamento

Author

Dendramis, G., Paleologo, C., Lo Presti, A., Piraino, D., Lo Greco, V., Grassedonio, E., La Grutta, L., Midiri, M., Assenato, P., and Novo, S.

Subjects
Atherosclerosis, Coronary artery disease, Coronary artery ectasia, Etiology, Matrix metalloproteinases, Settore MED/11 - Malattie Dell'Apparato Cardiovascolare
Published
2014

28. ORAL AB AGORA1362Cardiac Involvement in Patients With Different Rheumatic Disorders1366Gender differences in the development of cardiac complications: a multicentric prospective study in a large cohort of thalassemia major patients1646Comparison of T1-mapping, T2-weighted and contrast-enhanced cine imaging at 3.0T CMR for diagnostic oedema assessment in ST-segment elevation myocardial infarction1375Evaluation of Tissue Changes in Remote Noninfarcted Myocardium after Acute Myocardial Infarction using T1-mapping1377Right ventricular long axis strain – The prognostic value of a novel parameter in non-ischemic dilated cardiomyopathy using standard cardiac magnetic resonance imaging1389The role of the right ventricular insertion point in heart failure patients with preserved ejection fraction: Insights from a cardiovascular magnetic resonance study1398Myocardial fibrosis associates with B-type natriuretic peptide levels and outcomes more than wall stress1478Prognostic Value of Pulmonary Blood Volume by Contrast-Enhanced Magnetic Resonance Imaging in Heart Failure Outpatients – The PROVE-HF Study1370Magnetic Resonance Adenosine Perfusion Imaging as Gatekeeper of Invasive Coronary1509Influence of non-invasive hemodynamic CMR parameters on maximal exercise capacity in surgically untreated patients with Ebstein's anomaly1356Proximal aortic stiffening in Turner patients is more pronounced in the presence of a bicuspid valve. A segmental functional MRI study1503Flow pattern and vascular distensibility of the pulmonary arteries in patients after repair of tetralogy of Fallot. Insights from 4D flow CMR1516Myocardial deformation characteristics of the systemic right ventricle after atrial switch operation for transposition of the great arteries1633Three-dimensional vortex formation in patients with a Fontan circulation: evaluation with 4D flow CMR1483Mitral valve prolapse: arrhythmogenic substrates by cardiac magnetic imaging1596Increased local wall shear stress after coarctation repair is associated with descending aorta pulse wave velocity: evaluation with CMR and 4D flow1636Three-dimensional wall shear stress assessed by 4Dflow CMR in bicuspid aortic valve disease1464Cardiac Amyloidosis and Aortic Stenosis – The Convergence of Two Aging Processes1630Blood T1 variability explained in healthy volunteers: an analysis on MOLLI, ShMOLLI and SASHA1408Myocardial deformation on CMR predicts adverse outcomes in carcinoid heart disease - a new marker of risk1492Myocardial Perfusion Reserve and Global Longitudinal Strain in Early Rheumatoid Arthritis1500Exercise CMR to differentiate athlete's heart from patients with early dilated cardiomyopathy1559Real-Time, x-mri guidance to optimise left ventricular lead placement for delivery of cardiac resynchronisation therapy1560The role of Cardiac magnetic resonance imaging in patients undergoing ablation for ventricular tachycardia- Defining the substrate and visualizing the outcome1590Impact of cardiovascular magnetic resonance on clinical management and decision-making of out of hospital cardiac arrest survivors with inconclusive coronary angiogram1561Detection of coronary stenosis at rest using Oxygenation-Sensitive Magnetic Resonance Imaging

Author

Greulich, S., primary, Meloni, A., primary, Nazir, Sheraz A., primary, Stefan Biesbroek, P., primary, Arenja, Nisha, primary, Kammerlander, Andreas A., primary, Sayeed, Aatif, primary, Ricci, F., primary, Bernhardt, Peter, primary, Meierhofer, Christian, primary, Devos, Daniel G.H., primary, Ruecker, Beate, primary, Burkhardt, B.E.U., primary, Kamphuis, Vivian P., primary, De Lazzari, Manuel, primary, Nederend, I., primary, Dux-Santoy, Lydia, primary, Cavalcante, João L., primary, Rosmini, Stefania, primary, Liu, B., primary, Fent, G.J., primary, Claessen, G., primary, Behar, Jonathan, primary, Oebel, S., primary, Baritussio, A., primary, Ranjit Arnold, J., primary, Kitterer, D., additional, Latus, J., additional, Henes, J., additional, Kurmann, R., additional, Gloekler, S., additional, Wahl, A., additional, Buss, S., additional, Katus, H., additional, Bobbo, M., additional, Lombardi, M., additional, Braun, N., additional, Alscher, M.D., additional, Sechtem, U., additional, Mahrholdt, H., additional, Neri, M.G., additional, Preziosi, P., additional, Grassedonio, E., additional, Schicchi, N., additional, Keilberg, P., additional, Pulini, S., additional, Facchini, E., additional, Positano, V., additional, Pepe, A., additional, Shetye, Abhishek, additional, Khan, Jamal N., additional, Singh, Anvesha, additional, Kanagala, Prathap, additional, Swarbrick, Daniel, additional, Gulsin, Gaurav, additional, Graham-Brown, Matthew, additional, Squire, Iain, additional, Gershlick, Anthony, additional, McCann, Gerry P., additional, Amier, Raquel P., additional, Teunissen, Paul F.A., additional, Robbers, Lourens F.H.J., additional, Beek, Aernout M., additional, van Rossum, Albert C., additional, Hofman, Mark B.M., additional, van Royen, Niels, additional, Nijveldt, Robin, additional, Riffel, Johannes H, additional, Djiokou, Charly Noel, additional, Andre, Florian, additional, Fritz, Thomas, additional, Halder, Manuel, additional, Thomas, Zelniker, additional, Korosoglou, Grigorios, additional, Katus, Hugo A, additional, Buss, Sebastian J, additional, Schwaiger, Marianne L., additional, Duca, Franz, additional, Aschauer, Stefan, additional, Marzluf, Beatrice A., additional, Zotter-Tufaro, Caroline, additional, Dalos, Daniel, additional, Pfaffenberger, Stefan, additional, Bonderman, Diana, additional, Mascherbauer, Julia, additional, Fridman, Yaron, additional, Hackman, Brianne, additional, Kadakkal, Ajay, additional, Maanja, Maren, additional, Daya, Hussein Abu, additional, Wong, Timothy C., additional, Schelbert, Erik B., additional, Barison, A., additional, Todiere, G., additional, Gaeta, R., additional, Galllina, S., additional, Emdin, M., additional, De Caterina, R., additional, Aquaro, G.D., additional, Buckert, Dominik, additional, Dyckmanns, Nils, additional, Rottbauer, Wolfgang, additional, Kühn, Andreas, additional, Shehu, Nerejda, additional, Müller, Jan, additional, Stern, Heiko, additional, Ewert, Peter, additional, Fratz, Sohrab, additional, Vogt, Manfred, additional, De Groote, Katya, additional, Babin, Danilo, additional, Demulier, Laurent, additional, Taeymans, Yves, additional, Westenberg, Jos J., additional, Van Bortel, Luc, additional, Segers, Patrick, additional, Achten, Eric, additional, De Schepper, Jean, additional, Rietzschel, Ernst, additional, Geiger, Julia, additional, Makki, Malek, additional, Burkhardt, Barbara, additional, Kellenberger, Christian J., additional, Buechel, Emanuela R. Valsangiacomo, additional, Kellenberger, C.J., additional, Geiger, J., additional, Ruecker, B., additional, Buechel, E.R. Valsangiacomo, additional, Elbaz, Mohammed S.M., additional, Kroft, Lucia J.M., additional, van der Geest, Rob J., additional, de Roos, Albert, additional, Blom, Nico A., additional, Westenberg, Jos J.M., additional, Roest, Arno A.W., additional, Cipriani, Alberto, additional, Susana, Angela, additional, Rizzo, Stefania, additional, Giorgi, Benedetta, additional, Carmelo, Lacognata, additional, Bertaglia, Emanuele, additional, Bauce, Barbara, additional, Corrado, Domenico, additional, Thiene, Gaetano, additional, Marra, Martina Perazzolo, additional, Basso, Cristina, additional, Iliceto, Sabino, additional, Roest, A.A.W., additional, van den Boogaard, P.J., additional, ten Harkel, A.D.J., additional, de Geus, J.C.N., additional, Kroft, L.J.M., additional, de Roos, A., additional, Westenberg, J.J.M., additional, Kale, Raquel, additional, Teixido-Tura, Gisela, additional, Maldonado, Giuliana, additional, Huguet, Marina, additional, Garcia-Dorado, David, additional, Evangelista, Artur, additional, Rodriguez-Palomares, Jose, additional, Rijal, Shasank, additional, Schindler, John T., additional, Gleason, Thomas G., additional, Lee, Joon S., additional, Bulluck, Heerajnarain, additional, Treibel, Thomas A, additional, Bhuva, Anish, additional, Abdel-Gadir, Amna, additional, Culotta, Veronica, additional, Merghani, Ahmed, additional, Maestrini, Viviana, additional, Herrey, Anna S, additional, Kellman, Peter, additional, Manisty, Charlotte, additional, Moon, James C, additional, Hayer, M.K., additional, Baig, S., additional, Shah, T., additional, Rooney, S.J., additional, Edwards, N.C., additional, Steeds, R.P., additional, Garg, P., additional, Swoboda, P., additional, Dobson, L.E., additional, Musa, T.A., additional, Foley, J.F., additional, Haaf, P., additional, Greenwood, J.P., additional, Plein, S., additional, Schnell, F., additional, Bogaert, J., additional, Dymarkowski, S., additional, Pattyn, N., additional, Claus, P., additional, Van Cleemput, J., additional, Gerche, A. La, additional, Heidbuchel, H., additional, Toth, Daniel, additional, Reiml, Sabrina, additional, Panayiotou, Maria, additional, Claridge, Simon, additional, Jackson, Tom, additional, Sohal, Manav, additional, Webb, Jessica, additional, O'Neill, Mark, additional, Brost, Alexander, additional, Mountney, Peter, additional, Razavi, Reza, additional, Rhode, Kawal, additional, Rinaldi, Christopher Aldo, additional, Arya, A., additional, Hilbert, S., additional, Bollmann, A., additional, Hindricks, G., additional, Jahnke, C., additional, Paetsch, I., additional, Dinov, B., additional, Perazzolo Marra, M., additional, Ghosh Dastidar, A., additional, Rodrigues, J., additional, Zorzi, A., additional, Susana, A., additional, Scatteia, A., additional, De Garate, E., additional, Mattesi, G., additional, Strange, J., additional, Corrado, D., additional, Bucciarelli-Ducci, C., additional, Jerosch-Herold, Michael, additional, Karamitsos, Theodoros D., additional, Francis, Jane M., additional, Bhamra-Ariza, Paul, additional, Sarwar, Rizwan, additional, Choudhury, Robin, additional, Selvanayagam, Joseph B., additional, and Neubauer, Stefan, additional

Published
2016
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32. These abstracts have been selected for VIEWING only as ePosters and in print. ePosters will be available on Screen A & B throughout the meeting, Print Posters at the times indicated below. Please refer to the PROGRAM for more details.

Author

Secchi, F., primary, Cannao, P., additional, Pluchinotta, F., additional, Butera, G., additional, Carminati, M., additional, Sardanelli, F., additional, Lombardi, M., additional, Monney, P., additional, Piccini, D., additional, Rutz, T., additional, Vincenti, G., additional, Coppo, S., additional, Koestner, S., additional, Stuber, M., additional, Schwitter, J., additional, Romana, P., additional, Francesco, S., additional, Gianfranco, B., additional, Mario, C., additional, Massimo, L., additional, Alizadeh Sani, Z., additional, Vojdan-Parast, M., additional, Alimohammadi, M., additional, Sarafan-Sadeghi, S., additional, Seifi, A., additional, Fallahabadi, H., additional, Karami Tanha, F., additional, Jamshidi, M., additional, Hesamy, M., additional, Bonello, B., additional, Sorensen, C., additional, Fouilloux, V., additional, Gorincour, G., additional, Mace, L., additional, Fraisse, A., additional, Jacquier, A., additional, de Meester, C., additional, Amzulescu, M., additional, Bouzin, C., additional, Boileau, L., additional, Melchior, J., additional, Boulif, J., additional, Lazam, S., additional, Pasquet, A., additional, Vancrayenest, D., additional, Vanoverschelde, J., additional, Gerber, B., additional, Loudon, M., additional, Bull, S., additional, Bissell, M., additional, Joseph, J., additional, Neubauer, S., additional, Myerson, S., additional, Dorniak, K., additional, Hellmann, M., additional, Rawicz-Zegrzda, D., additional, W sierska, M., additional, Sabisz, A., additional, Szurowska, E., additional, Heiberg, E., additional, Dudziak, M., additional, Kwok, T., additional, Chin, C., additional, Dweck, M., additional, Hadamitzky, M., additional, Nadjiri, J., additional, Hendrich, E., additional, Pankalla, C., additional, Will, A., additional, Schunkert, H., additional, Martinoff, S., additional, Sonne, C., additional, Pepe, A., additional, Meloni, A., additional, Terrazzino, F., additional, Spasiano, A., additional, Filosa, A., additional, Bitti, P., additional, Tangari, C., additional, Restaino, G., additional, Resta, M., additional, Ricchi, P., additional, Tudisca, C., additional, Grassedonio, E., additional, Positano, V., additional, Piraino, B., additional, Romano, N., additional, Keilberg, P., additional, Midiri, M., additional, Macchi, S., additional, Ambrosio, D., additional, De Marchi, D., additional, Chiodi, E., additional, Salvatori, C., additional, Artang, R., additional, Bogachkov, A., additional, Botelho, M., additional, Bou-Ayache, J., additional, Vazquez, M., additional, Carr, J., additional, Collins, J., additional, Maret, E., additional, Ahlander, B., additional, Bjorklund, P., additional, Engvall, J., additional, Cimermancic, R., additional, Inage, A., additional, Mizuno, N., additional, Santarelli, M., additional, Izzi, G., additional, Maddaloni, D., additional, Landini, L., additional, Carulli, G., additional, Oliva, E., additional, Arcioni, F., additional, Fraticelli, V., additional, Toia, P., additional, Renne, S., additional, Rizzo, M., additional, Reinstadler, S., additional, Klug, G., additional, Feistritzer, H., additional, Aschauer, A., additional, Schocke, M., additional, Franz, W., additional, Metzler, B., additional, Melonil, A., additional, Positanol, V., additional, Roccamo, G., additional, Argento, C., additional, Benni, M., additional, De Marchil, D., additional, Missere, M., additional, Prezios, P., additional, Salvatoril, C., additional, Pepel, A., additional, Rossi, G., additional, Cirotto, C., additional, Filati, G., additional, Preziosi, P., additional, Mongeon, F., additional, Fischer, K., additional, Teixeira, T., additional, Friedrich, M., additional, Marcotte, F., additional, Zenge, M., additional, Schmidt, M., additional, Nadar, M., additional, Chevre, P., additional, Rohner, C., additional, Mouratoglou, S., additional, Kallifatidis, A., additional, Giannakoulas, G., additional, Grapsa, J., additional, Kamperidis, V., additional, Pitsiou, G., additional, Stanopoulos, I., additional, Hadjimiltiades, S., additional, Karvounis, H., additional, Ahmed, N., additional, Lawton, C., additional, Ghosh Dastidar, A., additional, Frontera, A., additional, Jackson, A., additional, Cripps, T., additional, Diab, I., additional, Duncan, E., additional, Thomas, G., additional, Bucciarelli-Ducci, C., additional, Kannoly, S., additional, Gosling, O., additional, Ninan, T., additional, Fulford, J., additional, Dalrymple-Haym, M., additional, Shore, A., additional, Bellenger, N., additional, Alegret, J., additional, Beltran, R., additional, Martin, M., additional, Mendoza, M., additional, Elisabetta, C., additional, Teresa, C., additional, Zairo, F., additional, Marcello, N., additional, Clorinda, M., additional, Bruna, M., additional, Vincenzo, P., additional, Alessia, P., additional, Giorgio, B., additional, Mair, J., additional, Kremser, C., additional, Aschauer, S., additional, Tufaro, C., additional, Kammerlander, A., additional, Pfaffenberger, S., additional, Marzluf, B., additional, Bonderman, D., additional, Mascherbauer, J., additional, Kliegel, A., additional, Sailer, A., additional, Brustbauer, R., additional, Sedivy, R., additional, Mayr, H., additional, Manessi, M., additional, Castelvecchio, S., additional, Votta, E., additional, Stevanella, M., additional, Menicanti, L., additional, Secchi, F., additional, Redaelli, A., additional, Reiter, U., additional, Reiter, G., additional, Kovacs, G., additional, Greiser, A., additional, Olschewski, H., additional, Fuchsjager, M., additional, Babayev, J., additional, Mlynarski, R., additional, Mlynarska, A., additional, Sosnowski, M., additional, Pontone, G., additional, Bertella, E., additional, Petulla, M., additional, Russo, E., additional, Innocenti, E., additional, Baggiano, A., additional, Mushtaq, S., additional, Gripari, P., additional, Andreini, D., additional, Tondo, C., additional, Nyktari, E., additional, Izgi, C., additional, Haidar, S., additional, Wage, R., additional, Keegan, J., additional, Wong, T., additional, Mohiaddin, R., additional, Durante, A., additional, Rimoldi, O., additional, Laforgia, P., additional, Gianni, U., additional, Benedetti, G., additional, Cava, M., additional, Damascelli, A., additional, Laricchia, A., additional, Ancona, M., additional, Aurelio, A., additional, Pizzetti, G., additional, Esposito, A., additional, Margonato, A., additional, Colombo, A., additional, De Cobelli, F., additional, Camici, P., additional, Zvaigzne, L., additional, Sergejenko, S., additional, Kal js, O., additional, Ripley, D., additional, Swarbrick, D., additional, Hossain, E., additional, Chawner, R., additional, Moore, J., additional, Aquaro, G., additional, Barison, A., additional, Masci, P., additional, Todiere, G., additional, Strata, E., additional, Di Bella, G., additional, Monasterio, F., additional, Levelt, E., additional, Mahmod, M., additional, Ntusi, N., additional, Ariga, R., additional, Upton, R., additional, Piechnick, S., additional, Francis, J., additional, Schneider, J., additional, Stoll, V., additional, Davis, A., additional, Karamitsos, T., additional, Leeson, P., additional, Holloway, C., additional, Clarke, K., additional, Karwat, K., additional, Tomala, M., additional, Miszalski-Jamka, K., additional, Mrozi ska, S., additional, Kowalczyk, M., additional, Mazur, W., additional, Kereiakes, D., additional, Nessler, J., additional, Zmudka, K., additional, Ja wiec, P., additional, Miszalski-Jamka, T., additional, Ben Yaacoub-Kzadri, I., additional, Harguem, S., additional, Bennaceur, R., additional, Ganzoui, I., additional, Ben Miled, A., additional, Mnif, N., additional, Rodriguez Palomares, J., additional, Ortiz, J., additional, Tejedor, P., additional, Lee, D., additional, Wu, E., additional, Bonow, R., additional, Khanji, M., additional, Castiello, T., additional, Westwood, M., additional, Petersen, S., additional, Storti, S., additional, Quota, A., additional, Smacchia, M., additional, Paci, C., additional, Vallone, A., additional, Valeri, G., additional, keilberg, P., additional, Gargani, L., additional, Guiducci, S., additional, Pugliese, N., additional, Pingitore, A., additional, Cole, B., additional, Douglas, H., additional, Rodden, S., additional, Horan, P., additional, Harbinson, M., additional, Johnston, N., additional, Dixon, L., additional, Choudhary, P., additional, Hsu, C., additional, Grieve, S., additional, Semsarian, C., additional, Richmond, D., additional, Celermajer, D., additional, Puranik, R., additional, Hinojar Baydes, R., additional, Varma, N., additional, Goodman, B., additional, Khan, S., additional, Arroyo Ucar, E., additional, Dabir, D., additional, Schaeffter, T., additional, Nagel, E., additional, Puntmann, V., additional, Hinojar, R., additional, Ucar, E., additional, Ngah, N., additional, Kuo, N., additional, D'Cruz, D., additional, Gaddum, N., additional, Foote, L., additional, Schnackenburg, B., additional, Higgins, D., additional, Nucifora, G., additional, Muser, D., additional, Morocutti, G., additional, Gianfagna, P., additional, Zanuttini, D., additional, Piccoli, G., additional, Proclemer, A., additional, Prati, G., additional, Vitrella, G., additional, Allocca, G., additional, Buttignoni, S., additional, Delise, P., additional, Sinagra, G., additional, Silva, G., additional, Almeida, A., additional, David, C., additional, Francisco, A., additional, Magalhaes, A., additional, Placido, R., additional, Menezes, M., additional, Guimaraes, T., additional, Mendes, A., additional, Nunes Diogo, A., additional, Aneq, M., additional, Papavassiliu, T., additional, Sandberg, R., additional, Schimpf, R., additional, Schoenberg, S., additional, Borggrefe, M., additional, Doesch, C., additional, Tamin, S., additional, Tan, L., additional, Joshi, S., additional, Memon, S., additional, Tangcharoen, T., additional, Prasertkulchai, W., additional, Yamwong, S., additional, Sritara, P., additional, Binti Ngah, N., additional, Cruz, D., additional, Rebellato, L., additional, Daleffe, E., additional, Facchin, D., additional, Melao, F., additional, Paiva, M., additional, Pinho, T., additional, Martins, E., additional, Vasconcelos, M., additional, Madureira, A., additional, Macedo, F., additional, Ramos, I., additional, Maciel, M., additional, Agoston-Coldea, L., additional, Marjanovic, Z., additional, Hadj Khelifa, S., additional, Kachenoura, N., additional, Lupu, S., additional, Soulat, G., additional, Farge-Bancel, D., additional, Mousseaux, E., additional, Dastidar, A., additional, Augustine, D., additional, McAlindon, E., additional, Leite, S., additional, Sousa, C., additional, Rangel, I., additional, El ghannudi, S., additional, Lefoulon, A., additional, Noel, E., additional, Germain, P., additional, Doutreleau, S., additional, Jeung, M., additional, Gangi, A., additional, Roy, C., additional, Pisciella, L., additional, Zachara, E., additional, Federica, R., additional, Emdin, M., additional, Baydes, R., additional, Mahmoud, I., additional, and Jackson, T., additional

Published
2014
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33. Comparison of iodinated contrast media for the assessment of atherosclerotic plaque attenuation values by CT coronary angiography: Observations in an ex vivo model

Author

Grutta, L. (Ludovico) la, Galia, M. (Massimo), Gentile, G., Lo Re, G. (G.), Grassedonio, E. (Emanuele), Coppolino, F., Maffei, E. (Erica), Maresi, E. (E.), Lo Casto, A. (A.), Cademartiri, F. (Filippo), Midiri, M. (Massimo), Grutta, L. (Ludovico) la, Galia, M. (Massimo), Gentile, G., Lo Re, G. (G.), Grassedonio, E. (Emanuele), Coppolino, F., Maffei, E. (Erica), Maresi, E. (E.), Lo Casto, A. (A.), Cademartiri, F. (Filippo), and Midiri, M. (Massimo)

Abstract

Objective: To compare the influence of different iodinated contrast media with several dilutions on plaque attenuation in an ex vivo coronary model studied by multislice CT coronary angiography. Methods: In six ex vivo left anterior descending coronary arteries immersed in oil, CT (slices/collimation 64x0.625mm, temporal resolution 210 ms, pitch 0.2) was performed after intracoronary injection of a saline solution, and solutions of a dimeric isosmolar contrast medium (Iodixanol 320 mgI ml-1) and a monomeric high-iodinated contrast medium (Iomeprol 400 mgI ml-1) with dilutions of 1/80 (low concentration), 1/50 (medium concentration), 1/40 (high concentration) and 1/20 (very high concentration). Two radiologists drew regions of interest in the lumen and in calcified and non-calcified plaques for each solution. 29 cross-sections with non-calcified plaques and 32 cross-sections with calcified plaques were evaluated. Results: Both contrast media showed different attenuation values within lumen and plaque (p<0.0001). The correlation between lumen and non-calcified plaque values was good (Iodixanol r=0.793, Iomeprol r=0.647). Clustered medium- and high-concentration solutions showed similar plaque attenuation values, signal-to-noise ratios (SNRs) (non-calcified plaque: mediumsolution SNR 31.3±15 vs 31.4±20, high solution SNR 39.4±17 vs 37.4±22; calcified plaque: medium solution SNR 305.2±133 vs 298.8±132, high solution SNR 323.9±138 vs 293±123) and derived contrast-to-noise ratios (p>0.05). Conclusion: Differently iodinated contrast media have a similar influence on plaque attenuation profiles. Advances in knowledge: Since iodine load affects coronary plaque attenuation linearly, different contrast media may be equally employed for coronary atherosclerotic plaque imaging.

Published
2013
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34. Atherosclerotic pattern of coronary myocardial bridging assessed with CT coronary angiography

Author

Grutta, L. (Ludovico) la, Runza, G. (Giuseppe), Galia, M. (Massimo), Maffei, E. (Erica), Lo Re, G. (Giuseppe), Grassedonio, E. (Emanuele), Tedeschi, C. (Carlo), Cademartiri, F. (Filippo), Midiri, M. (Massimo), Grutta, L. (Ludovico) la, Runza, G. (Giuseppe), Galia, M. (Massimo), Maffei, E. (Erica), Lo Re, G. (Giuseppe), Grassedonio, E. (Emanuele), Tedeschi, C. (Carlo), Cademartiri, F. (Filippo), and Midiri, M. (Massimo)

Abstract

The aim of our study was to evaluate the atherosclerotic pattern of patients with coronary myocardial bridging (MB) by means of CT Coronary Angiography (CT-CA). 254 consecutive patients (166 male, mean age 58.6 ± 10.3) who underwent 64-slice CT-CA according to current clinical indications were reviewed for the presence of MB and concomitant segmental atherosclerotic pattern. Coronary plaques were assessed in all patients enrolled. 73 patients (29%) presented single (90%) or multiple (10%) MB, frequently (93%) localized in the mid-distal left anterior descending artery. The MB segment was always free of atherosclerosis. Segments proximal to the MB presented: no atherosclerotic disease (n = 37), positive remodeling (n = 23), <50% (n = 14), or >50% stenoses (n = 7). Distal segments presented a different atherosclerosis pattern (P < 0.0001): absence of disease (n = 73), no significant lesions (n = 8). No significant differences were found between segments proximal to MB and proximal coronary segments apart from left main trunk. Pattern of atherosclerotic lesions located in segments 6 and 7 significantly differs between patients with MB and patients without MB (P < 0.05). CT-CA is a reliable method to non-invasively demonstrate MB and related atherosclerotic pattern. CT-CA provides new insight regarding atherosclerosis distribution in segments close to MB.

Published
2012
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35. Atherosclerotic pattern of coronary myocardial bridging assessed with CT coronary angiography

Author

la Grutta, L, Runza, G, Galia, M, Maffei, E, Lo Re, G, Grassedonio, E, Tedeschi, C, Cademartiri, F., Midiri, M, la Grutta, L, Runza, G, Galia, M, Maffei, E, Lo Re, G, Grassedonio, E, Tedeschi, C, Cademartiri, F., and Midiri, M

Abstract

The aim of our study was to evaluate the atherosclerotic pattern of patients with coronary myocardial bridging (MB) by means of CT Coronary Angiography (CT-CA). 254 consecutive patients (166 male, mean age 58.6 +/- A 10.3) who underwent 64-slice CT-CA according to current clinical indications were reviewed for the presence of MB and concomitant segmental atherosclerotic pattern. Coronary plaques were assessed in all patients enrolled. 73 patients (29%) presented single (90%) or multiple (10%) MB, frequently (93%) localized in the mid-distal left anterior descending artery. The MB segment was always free of atherosclerosis. Segments proximal to the MB presented: no atherosclerotic disease (n = 37), positive remodeling (n = 23), < 50% (n = 14), or > 50% stenoses (n = 7). Distal segments presented a different atherosclerosis pattern (P < 0.0001): absence of disease (n = 73), no significant lesions (n = 8). No significant differences were found between segments proximal to MB and proximal coronary segments apart from left main trunk. Pattern of atherosclerotic lesions located in segments 6 and 7 significantly differs between patients with MB and patients without MB (P < 0.05). CT-CA is a reliable method to non-invasively demonstrate MB and related atherosclerotic pattern. CT-CA provides new insight regarding atherosclerosis distribution in segments close to MB.

Published
2012

38. Comparison of iodinated contrast media for the assessment of atherosclerotic plaque attenuation values by CT coronary angiography: observations in an ex vivo model.

Author

LA GRUTTA, L., GALIA, M., GENTILE, G., LO RE, G., GRASSEDONIO, E., COPPOLINO, F., MAFFEI, E., MARESI, E., LO CASTO, A., CADEMARTIRI, F., and MIDIRI, M.

Subjects
ATHEROSCLEROTIC plaque, COMPARATIVE studies, CORONARY angiography, TOMOGRAPHY, SIGNAL-to-noise ratio, ATTENUATION coefficients
Abstract

Objective: To compare the influence of different iodinated contrast media with several dilutions on plaque attenuation in an ex vivo coronary model studied by multislice CT coronary angiography. Methods: In six ex vivo left anterior descending coronary arteries immersed in oil, CT (slices/collimation 64x0.625mm, temporal resolution 210ms, pitch 0.2) was performed after intracoronary injection of a saline solution, and solutions of a dimeric isosmolar contrast medium (lodixanol 320 mgI ml-1) and a monomeric high-iodinated contrast medium (lomeprol 400 mgI ml-1) with dilutions of 1/80 (low concentration), 1/50 (medium concentration), 1/40 (high concentration) and 1/20 (very high concentration). Two radiologists drew regions of interest in the lumen and in calcified and non-calcified plaques for each solution. 29 cross-sections with non-calcified plaques and 32 cross-sections with calcified plaques were evaluated. Results: Both contrast media showed different attenuation values within lumen and plaque (p<0.0001). The correlation between lumen and non-calcified plaque values was good (lodixanol r=0.793, lomeprol r=0.647). Clustered medium- and high-concentration solutions showed similar plaque attenuation values, signal-to-noise ratios (SNRs) (non-calcified plaque: medium solution SNR 31.3 ± 15 vs 31.4±20, high solution SNR 39.4±17 vs 37.4± 22; calcified plaque: medium solution SNR 305.2±133 vs 298.8± 132, high solution SNR 323.9±138 vs 293±123) and derived contrast-to-noise ratios (p>0.05). Conclusion: Differently iodinated contrast media have a similar influence on plaque attenuation profiles. Advances in knowledge: Since iodine load affects coronary plaque attenuation linearly, different contrast media may be equally employed for coronary atherosclerotic plaque imaging. [ABSTRACT FROM AUTHOR]

Published
2013
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39. Prevalence of myocardial bridging and correlation with coronary atherosclerosis studied with 64-slice CT coronary angiography.

Author

Grutta, L., Runza, G., Re, G., Galia, M., Alaimo, V., Grassedonio, E., Bartolotta, T.V., Malagò, R., Tedeschi, C., Cademartiri, F., Maria, M., Cardinale, A.E., Lagalla, R., and Midiri, M.

Abstract

Copyright of La Radiologia Medica is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2009
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41. Ventricular arrhythmias in children: the uselessness of MRI

Author

Fazio, G., Grassedonio, E., Massimo Galia, Mongiovi, M., Novo, G., Sutera, L., D Angelo, L., Visconti, C., Evola, G., Pipitone, S., Midiri, M., Novo, S., Fazio,G, Grassedonio,E, Galia,M, Mongiovi',M, Novo,G, Sutera,L, D'angelo,L, Visconti,C, Evola,G, Pipitone,S, Midiri,M, and Novo,S.

Subjects
Electrocardiography, Adolescent, Heart Conduction System, Predictive Value of Tests, arrhythmias,MRI, Settore MED/20 - Chirurgia Pediatrica E Infantile, Tachycardia, Ventricular, Humans, Settore MED/11 - Malattie Dell'Apparato Cardiovascolare, Magnetic Resonance Imaging, Sensitivity and Specificity, Arrhythmogenic Right Ventricular Dysplasia

43. Takotsubo cardiomyopathy after a positive emotional stress

Author

Novo, G., Grassedonio, E., Rotolo, A., Fiore, M., Pugliesi, M., Dimiceli, R., Lupo, A., Giambanco, S., Midiri, M., Novo, S., Pasquale Assennato, Novo, G, Grassedonio, E, Rotolo, A, Fiore, M, Pugliesi, M, Dimiceli, R, Lupo, A, Giambanco, S, Midiri, M, Novo, S, and Assennato, P

Subjects
Takotsubo cardiomyopathy, emotional stress, left ventricular dysfunction, coronary syndrome
Abstract

Takotsubo cardiomyopathy, also known as transient left ventricular apical ballooning syndrome, is a cardiac syndrome mimicking an acute coronary syndrome and characterized by peculiar transient left ventricular wall motion in the absence of significant coronary lesions at coronary angiography. The pathogenic mechanisms linking emotional stress to Takotsubo cardiomyopathy still remain undefined. The onset of Takotsubo cardiomyopathy can be triggered by an acute, intense emotional stress. This is the first report reporting that not only negative stress but also positive stressful event may precede the syndrome.

44. Ventricular arrhythmias in children: The uselessness of MRI

Author

giovanni fazio, Grassedonio E, Cracolici E, Mongiovi M, Novo G, Sutera L, D'Angelo L, Visconti C, Spoto S, Pipitone S, Ferrara F, Midiri M, Novo S, Fazio G, Grassedonio E, Cracolici E, Mongiovi,M, Novo,G, Sutera,L, D'Angelo,L, Visconti,C, Spoto,S, Pipitone,S, Ferrara,F, Midiri,M, and Novo,S.

Subjects
Ventricular arrhythmias, Settore MED/38 - Pediatria Generale E Specialistica, Adolescent, Heart Ventricles, Patient Selection, Humans, Arrhythmias, Cardiac, Magnetic Resonance Imaging, Settore MED/11 - Malattie Dell'Apparato Cardiovascolare

45. Native Mitral Valve Endocarditis Caused by Neisseria elongata subsp. nitroreducens in a Patient with Marfan Syndrome: First Case in Italy and Review of the Literature

Author

Parrinello Rossella, Carità Patrizia, Triolo Fabio Oreste, Trapani Renato, Grassedonio Emanuele, Argano Vincenzo, Novo Giuseppina, Vallone Silvana, Fasciana Teresa, Verdecchia Massimo, Giammanco Anna, Midiri Massimo, and Novo Salvatore

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Neisseria elongata (NE) is an aerobic Gram-negative organism that constitutes part of the commensal human normal oropharyngeal flora. Although previously considered not to be pathogenic, it has been recognized as an occasional cause of significant infections in humans. We report here the first case in Italy of infective endocarditis of a native prolapsing mitral valve in a patient with Marfan syndrome, caused by NE subspecies nitroreducens which has been rarely isolated from clinical specimens. The culprit organism has been confirmed by mass spectrometry directly from the positive blood culture, as previously reported. The amplified gene has been deposited in GenBank under accession number KT591873. In spite of the reported aggressive nature of NE, clinical remission was promptly obtained, there being no requirement for surgery.

Published
2016
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48. Abstracts

Author

Treibel, Thomas A., Fridman, Yaron, Hackman, Brianne, Kadakkal, Ajay, Sayeed, Aatif, Maanja, Maren, Daya, Hussein Abu, Moon, James C., Wong, Timothy C., Schelbert, Erik B., Duca, Franz, Kammerlander, Andreas A., Zotter-Tufaro, Caroline, Aschauer, Stefan, Bonderman, Diana, Mascherbauer, Julia, Schwitter, Juerg, Beigelman-Aubry, Catherine, Peguret, Nicolas, Stuber, Matthias, Delacoste, Jean, Belmondo, Bastien, Lovis, Alban, Simons, Julien, Long, Olivier, Grant, Kathleen, Berchier, Gregoire, Rohner, Chantal, Bonanno, Gabriele, Coppo, Simone, Ozsahin, Esat-Mahmut, Qanadli, Salah, Meuli, Reto, Bourhis, Jean, Ide, Seiko, Riesenkampff, Eugenie, Chiasson, David, Dipchand, Anne I., Kantor, Paul F., Chaturvedi, Rajiv R., Yoo, Shi-Joon, Grosse-Wortmann, Lars, Sandrini, C., Aquaro, GD, De Marchi, D, Ait Ali, L, Khraiche, D, Boddaert, N, Bonnet, D, Raimondi, F, Fridman, Yaron, Hackman, Brianne E., Kadakkal, Ajay, Daya, Hussein Abu, Wong, Timothy C., Schelbert, Erik B., Angela, Susana, Alberto, Cipriani, Manuel, De Lazzari, Federico, Marin, Francesca, Prevedello, Bendetta, Giorgi, Giorgio, De Conti, Giuseppe, Tarantini, Luisa, Cacciavillani, Emanuele, Bertaglia, Domenico, Corrado, Sabino, Iliceto, Martina, Perazzolo Marra, Camaioni, Claudia, Morlon, Lucas, Vergé, Marie-Philippe, Jais, Pierre, Roudaut, Raymond, Laurent, Francois, Lafitte, Stéphane, Cochet, Hubert, Réant, Patricia, Bohnen, S., Radunski, U. K., Lund, G. K., Senel, M., Avanesov, M., Tahir, E., Stehning, C., Adam, G., Blankenberg, S., Muellerleile, K., Khanji, Mohammed Y., Balawon, Armida, Boubertakh, Redha, Petersen, Steffen E, Hilbert, Sebastian, Spampinato, Ricardo, Oebel, Sabrina, Hindricks, Gerhard, Bollmann, Andreas, Jahnke, Cosima, Paetsch, Ingo, Goetschalckx, K., Bogaert, J., Desmet, W., Toth, A., Merkely, B., Janssens, S., Claus, P., Calvieri, C., Preda, M. B., Perfetti, A., Valaperta, R., Secchi, F., Fedele, F., Martelli, F., Lombardi, M., Reinstadler, Sebastian J., Eitel, Charlotte, Fuernau, Georg, de Waha, Suzanne, Desch, Steffen, Mende, Meinhard, Metzler, Bernhard, Schuler, Gerhard, Thiele, Holger, Eitel, Ingo, Maestrini, Viviana, Mun, Hong Cheang, Kotwinski, Paul, Rosmini, Stefania, Sanders, Julie, Lloyd, Guy, Dudley, J. Pennell, Kellman, Peter, Hugh, E. Montgomery, Manisty, Charlotte, James, C. Moon, James, S., Waterhouse, D.F., Murphy, T.M., Kenny, C., O'Hanlon, R., Bastiaenen, Rachel, Cox, Andrew T., Wijeyeratne, Yanushi, Colbeck, Nicholas, Pakroo, Nadia, Ahmed, Hammad, Bunce, Nick, Anderson, Lisa, Prasad, Sanjay, Sharma, Sanjay, Behr, Elijah R., Reid, A. B., Miller, C., Jovanovic, A., Woolfson, P., Abidin, N., Schmitt, M., Amadu, A.M., Rodrigues, J.C.L., Dastidar, A. Ghosh, Baritussio, A., Lawton, C., Venuti, G., Meloni, G.B., Conti, M., Bucciarelli-Ducci, C., Pontone, Gianluca, Andreini, Daniele, SoLbiati, Anna, Guglielmo, Marco, Mushtaq, Saima, Baggiano, Andrea, Beltrama, Virginia, Rota, Cristina, Guaricci, Andrea I., Pepi, Mauro, Wang, Yufei, Joannic, David, Juillion, Patrick, Delassus, P., Monnet, Aurélien, Lalande, Alain, Fontaine, Jean-Francois, Zweerink, A, Allaart, CP, Wu, L, Kuijer, JPA, Beek, AM, Croisille, P, Clarysse, P, van Rossum, AC, Nijveldt, R, Bulluck, Heerajnarain, Rosmini, Stefania, Abdel-Gadir, Amna, Bhuva, Anish, Treibel, Thomas A, White, Steven K, Hammond-Haley, Matthew, Sirker, Alex, Herrey, Anna, Manisty, Charlotte, Yellon, Derek M, Kellman, Peter, Moon, James C, Hausenloy, Derek J, Garg, P., Hassell, M, Foley, J., Ripley, D.P., Dobson, L., Swoboda, P.P., Fent, G., Musa, T.A., Erhayiem, B., Haaf, P., Greenwood, J.P., Nijveldt, R., Westenberg, J.J.M., Geest, R.J.V.D., Plein, S., Rodrigues, Jonathan C L, Amadu, Antonio Matteo, Dastidar, Amardeep Ghosh, Szantho, Gergley, Lyen, Stephen, Godsave, Cattleya, Ratcliffe, Laura E K, Burchell, Amy E, Hart, Emma C, Hamilton, Mark C K, Nightingale, Angus K, Paton, Julian F R, Manghat, Nathan E, Bucciarelli-Ducci, Chiara, Hafyane, Tarik, Teixeira, Tiago, Greiser, Andreas, Mongeon, Francois Pierre, Haifa, Almutairi, Mohammed, Khanji, Redha, Boubertakh, Marc, Miquel, Steffen, Petersen, Greulich, S., Kitterer, D., Latus, J., Henes, J., Kurmann, R., Gloekler, S., Wahl, A., Buss, S., Katus, H., Bobbo, M., Lombardi, M., Braun, N., Alscher, M.D., Sechtem, U., Mahrholdt, H., Meloni, A., Neri, M.G., Preziosi, P., Grassedonio, E., Schicchi, N., Keilberg, P., Pulini, S., Facchini, E., Positano, V., Pepe, A., Nazir, Sheraz A., Shetye, Abhishek, Khan, Jamal N., Singh, Anvesha, Kanagala, Prathap, Swarbrick, Daniel, Gulsin, Gaurav, Graham-Brown, Matthew, Squire, Iain, Gershlick, Anthony, McCann, Gerry P., Stefan Biesbroek, P., Amier, Raquel P., Teunissen, Paul F.A., Robbers, Lourens F.H.J., Beek, Aernout M., van Rossum, Albert C., Hofman, Mark B.M., van Royen, Niels, Nijveldt, Robin, Arenja, Nisha, Riffel, Johannes H, Djiokou, Charly Noel, Andre, Florian, Fritz, Thomas, Halder, Manuel, Thomas, Zelniker, Korosoglou, Grigorios, Katus, Hugo A, Buss, Sebastian J, Kammerlander, Andreas A., Schwaiger, Marianne L., Duca, Franz, Aschauer, Stefan, Marzluf, Beatrice A., Zotter-Tufaro, Caroline, Dalos, Daniel, Pfaffenberger, Stefan, Bonderman, Diana, Mascherbauer, Julia, Sayeed, Aatif, Fridman, Yaron, Hackman, Brianne, Kadakkal, Ajay, Maanja, Maren, Daya, Hussein Abu, Wong, Timothy C., Schelbert, Erik B., Ricci, F., Barison, A., Todiere, G., Gaeta, R., Galllina, S., Emdin, M., De Caterina, R., Aquaro, G.D., Bernhardt, Peter, Buckert, Dominik, Dyckmanns, Nils, Rottbauer, Wolfgang, Meierhofer, Christian, Kühn, Andreas, Shehu, Nerejda, Müller, Jan, Stern, Heiko, Ewert, Peter, Fratz, Sohrab, Vogt, Manfred, Devos, Daniel G.H., De Groote, Katya, Babin, Danilo, Demulier, Laurent, Taeymans, Yves, Westenberg, Jos J., Van Bortel, Luc, Segers, Patrick, Achten, Eric, De Schepper, Jean, Rietzschel, Ernst, Ruecker, Beate, Geiger, Julia, Makki, Malek, Burkhardt, Barbara, Kellenberger, Christian J., Buechel, Emanuela R. Valsangiacomo, Burkhardt, B.E.U., Kellenberger, C.J., Geiger, J., Ruecker, B., Buechel, E.R. Valsangiacomo, Kamphuis, Vivian P., Elbaz, Mohammed S.M., Kroft, Lucia J.M., van der Geest, Rob J., de Roos, Albert, Blom, Nico A., Westenberg, Jos J.M., Roest, Arno A.W., De Lazzari, Manuel, Cipriani, Alberto, Susana, Angela, Rizzo, Stefania, Giorgi, Benedetta, Carmelo, Lacognata, Bertaglia, Emanuele, Bauce, Barbara, Corrado, Domenico, Thiene, Gaetano, Marra, Martina Perazzolo, Basso, Cristina, Iliceto, Sabino, Nederend, I., Roest, A.A.W., van den Boogaard, P.J., ten Harkel, A.D.J., de Geus, J.C.N., Kroft, L.J.M., de Roos, A., Westenberg, J.J.M., Dux-Santoy, Lydia, Kale, Raquel, Teixido-Tura, Gisela, Maldonado, Giuliana, Huguet, Marina, Garcia-Dorado, David, Evangelista, Artur, Rodriguez-Palomares, Jose, Cavalcante, João L., Rijal, Shasank, Schindler, John T., Gleason, Thomas G., Lee, Joon S., Schelbert, Erik B., Rosmini, Stefania, Bulluck, Heerajnarain, Treibel, Thomas A, Bhuva, Anish, Abdel-Gadir, Amna, Culotta, Veronica, Merghani, Ahmed, Maestrini, Viviana, Herrey, Anna S, Kellman, Peter, Manisty, Charlotte, Moon, James C, Liu, B., Hayer, M.K., Baig, S., Shah, T., Rooney, S.J., Edwards, N.C., Steeds, R.P., Fent, G.J., Garg, P., Swoboda, P., Dobson, L.E., Musa, T.A., Foley, J.F., Haaf, P., Greenwood, J.P., Plein, S., Claessen, G., Schnell, F., Bogaert, J., Dymarkowski, S., Pattyn, N., Claus, P., Van Cleemput, J., Gerche, A. La, Heidbuchel, H., Behar, Jonathan, Toth, Daniel, Reiml, Sabrina, Panayiotou, Maria, Claridge, Simon, Jackson, Tom, Sohal, Manav, Webb, Jessica, O'Neill, Mark, Brost, Alexander, Mountney, Peter, Razavi, Reza, Rhode, Kawal, Rinaldi, Christopher Aldo, Oebel, S., Arya, A., Hilbert, S., Bollmann, A., Hindricks, G., Jahnke, C., Paetsch, I., Dinov, B., Baritussio, A., Perazzolo Marra, M., Ghosh Dastidar, A., Rodrigues, J., Zorzi, A., Susana, A., Scatteia, A., De Garate, E., Mattesi, G., Strange, J., Corrado, D., Bucciarelli-Ducci, C., Ranjit Arnold, J., Jerosch-Herold, Michael, Karamitsos, Theodoros D., Francis, Jane M., Bhamra-Ariza, Paul, Sarwar, Rizwan, Choudhury, Robin, Selvanayagam, Joseph B., Neubauer, Stefan, Tayal, Upasana, Scott, Andrew D, Wage, Rick, Ferreira, Pedro, Pennell, Dudley, Zhong, Xiaodong, Epstein, Fred, Firmin, David, Prasad, Sanjay, Kallifatidis, Alexandros, Prousalis, Anastasios, Mouratoglou, Sophia-Anastasia, Giannakoulas, George, Deligianni, Xenia, Bakaloudis, Michail, Magganaris, Nikolaos, Sianos, George, Karvounis, Haralampos, Santini, Francesco, Garg, P., Aziz, R., Foley, J.R.J., Fent, G., Musa, T.A., Haaf, P., Dobson, L., Swoboda, P.P., Greenwood, J.P., Plein, S., Geest, R.J.V.D., Westenberg, J.J.M., Beitzke, D., Rasul, S., Wadsak, W., Mitterhauser, M., Nolz, R., Stelzmueller, M., Loewe, C., Hacker, M., Funk, Stephanie, Kermer, Josephine, Dogangüzel, Serkan, von Knobelsdorff-Brenkenhoff, Florian, Schulz-Menger, Jeanette, Kolker, Shimon, Weisz, Giora, Bogot, Naama, Halpern, Irit Hadas, Wolak, Arik, Rutz, Tobias, Ginami, Giulia, Piccini, Davide, Coppo, Simone, Vincenti, Gabriella, Stuber, Matthias, Schwitter, Jürg, Safdar, Komal S, Gao, Xuexin, Ambach, Stephanie, Taylor, Michal D, Moore, Ryan, Taylor, Robin J, Toro-Salazar, Olga, Jeffries, John L, Bartone, Cheryl, Raman, Subha V, Mazur, Wojciech, Valente, F., Rodriguez-Palomares, J.F., Gutierrez, L., Pineda, V., Agliano, B., Galian, L., Teixido, G., Gonzalez-Alujas, M.T., Evangelista, A., Garcia-Dorado, D., Murdoch, R., Gandy, S., Nicholas, R., Houston, G., Martin, P., Muir, J., Matthew, S., Ramkumar, P. Guntur-, Cavin, I., Macaione, F., Barison, A., Pescetelli, I., Pali, F., Pizzino, F., Terrizzi, A., Di Lisi, D., Novo, G., Todiere, G., Assennato, P., Novo, S., Aquaro, G.D., Dastidar, Amardeep Ghosh, McAlindon, Elisa, Rodrigues, Jonathan, Baritussio, Anna, Scatteia, Alessandra, De Garate, Estefania, Benny Lawton, Chris, Erdei, Tamas, Szantho, Gergely, Hamilton, Mark, Bucciarelli-Ducci, Chiara, Pontone, Gianluca, Andreini, Daniele, Rota, Cristina, Guglielmo, Marco, Mushtaq, Saima, Baggiano, Andrea, Beltrama, Virginia, Solbiati, Anna, Guaricci, Andrea I., Pepi, Mauro, Grigoratos, Chrysanthos, Bratis, Konstantinos, Henningson, Markus, Dell'Omodarme, Matteo, Puntmann, Valentina O., Nagel, Eike, Meloni, Antonella, Giunta, Nicola, Giuliano, Pietro, Neri, Maria Giovanna, Restaino, Gennaro, Renne, Stefania, Quota, Alessandra, Positano, Vincenzo, De Marchi, Daniele, Pepe, Alessia, Pedrotti, Patrizia, Campadello, Paola, Masciocco, Gabriella, Facchetti, Rita, Milazzo, Angela, Quattrocchi, Giuseppina, Giannattasio, Cristina, Frigerio, Maria, Roghi, Alberto, Rimoldi, Ornella, De Garate, Estefania, Ghosh Dastidar, Amardeep, Baritussio, Anna, Scatteia, Alessandra, Amadu, Antonio, Venuti, Giuseppe, Rodrigues, Jonathan C., Bucciarelli-Ducci, Chiara, Careri, Giulia, Castelvecchio, Serenella, Camporeale, Antonia, Secchi, Francesco, Menicanti, Lorenzo, Lombardi, Massimo, Kockova, R., Sedlacek, K., Wichterle, D., Sikula, V., Tintera, J., Sukupova, L., Kautznerova, D., Segetova, M., Praveckova, A., Langova, R., Kryze, L., El-Husseini, W., Kautzner, J., Oebel, S., Dinov, B., Arya, A., Hilbert, S., Sommer, P., Bollmann, A., Hindricks, G., Paetsch, I., Jahnke, C., Nazir, Sheraz A., Greenwood, John P., Shetye, Abhishek, Khan, Jamal N., Singh, Anvesha, Kanagala, Prathap, Swarbrick, Daniel, Gulsin, Gaurav, Graham-Brown, Matthew, Gershlick, Anthony, McCann, Gerry P., Grigoratos, Chrysanthos, Liga, Riccardo, Bennatti, Elena, Barison, Andrea, Todiere, Giancarlo, Aquaro, Giovanni Donato, Dell'Omodarme, Matteo, Lombardi, Massimo, Emdin, Michele, Masci, Pier Giorgio, Barison, A, Ortalda, A, Todiere, G, Grigoratos, C, Vergaro, G, Mirizzi, G, Martini, N, De Marchi, D, Keilberg, P, Passino, C, Aquaro, GD, Emdin, M, Swoboda, Peter P, McDiarmid, Adam K, Erhayiem, Bara, Fent, Graham J, Dobson, Laura E, Garg, Pankaj, Musa, Tarique A, Foley, James R, Page, Stephen P, Greenwood, John P, Plein, Sven, Bulluck, Heerajnarain, Rosmini, Stefania, Abdel-Gadir, Amna, Bhuva, Anish, Treibel, Thomas A, White, Steven K, Fontana, Marianna, Ramlall, Manish, Hamarneh, Ashraf, Sirker, Alex, Herrey, Anna, Manisty, Charlotte, Yellon, Derek M, Kellman, Peter, Moon, James C, Hausenloy, Derek J, Broncano, J., Luna, A., Noguerol, T. Martin –, Caro, P., Toro-Cebada, R., Gonzalez, J. Sanchez –, Desroche, L.M., Milleron, O., Safar, B., Lavie-Badie, Y., Millischer, D., Abtan, J., Jondeau, G., Bermejo, Zorba Blázquez, Cuesta, Emilio, Rosillo, Sandra O., Guzmán, Gabriela, Pinilla, Inmaculada, González, Óscar, Caro, Juan, Ponz, Inés, López, Teresa, Refoyo, Elena, Kozor, Rebecca, Nordin, Sabrina, Treibel, Thomas A, Rosmini, Stefania, Castelleti, Silvia, Fontana, Marianna, Captur, Gabriella, Steeds, Rick, Baig, Shanat, Manisty, Charlotte, Grieve, Stuart M, Figtree, Gemma A, Moon, James C, Dastidar, Amardeep Ghosh, Rodrigues, Jonathan, De Garate, Estefania, Singhal, Priyanka, McAlindon, Elisa, Baritussio, Anna, Scatteia, Alessandra, Erdei, Tamas, Strange, Julian, Nightingale, Angus, Baumbach, Andreas, Johnson, Tom, Delgado, Victoria, Bucciarelli-Ducci, Chiara, Lapinskas, Tomas, Bucius, Paulius, Fedaravicius, Augustinas P., Urbonaite, Laura, Stabinskaite, Agnieta, Zaliunas, Remigijus, Elisabetta, Chiodi, Teresa, Cannizzaro Maria, Daniele, De Falco Alfano, Righi, Riccardo, Zerbini, Michela, Vincenzo, Positano, Cittanti, Corrado, Giganti, Melchiore, Giorgio, Benea, Grigoratos, Chrysanthos, Genovesi, Dario, Giorgetti, Assuero, Chiappino, Sara, Barison, Andrea, Vergaro, Giuseppe, Todiere, Giancarlo, Emdin, Michele, Marzullo, Paolo, Aquaro, Giovanni Donato, Ladeiras-Lopes, Ricardo, Turin-Moreira, Henrique, Bettencourt, Nuno, Fontes-Carvalho, Ricardo, Sampaio, Francisco, Ambale-Venkatesh, Bharath, Wu, Colin, Liu, Kiang, Bertoni, Alain, Ouyang, Pamela, Bluemke, David, Lima, João, Fent, GJ., Garg, P., Dobson, LE., Musa, TA., Foley, JF., Haaf, P., Greenwood, JP., Plein, S., Swoboda, PP., Abdul Rahman, E., Ismail, JR., Najme Khir, R., Lim, CW., Chua, N., Ibrahim, ZO., Zainal Abidin, HA., Mohd Arshad, MK., Kasim, SS., Rodrigues, Jonathan, Rooms, Ben, Hyde, Katie, Rohan, Stephen, Dastidar, Amardeep Ghosh, Hamilton, Mark, Bucciarelli-Ducci, Chiara, Nightingale, Angus, Paton, Julian, Manghat, Nathan, MacIver, David, Gibelli, Giuseppe, Demolli, Walter, Russo, Alessandra, Minoia, Chiara, Biasi, Salvatore, Mkrtchyan, Naira, Eltschkner, Christin, Christian, Meierhofer, Ewert, Peter, Martinoff, Stefan, Stern, Heiko, Fratz, Sohrab, Valinoti, Maddalena, Fabbri, Claudio, Mantovan, Roberto, Severi, Stefano, Corsi, Cristiana, Nyktari, E., Vassiliou, V., Arzanauskaite, M., Izgi, C., Lam, W., Prasad, S., Reindl, Martin, Reinstadler, Sebastian Johannes, Feistritzer, Hans-Josef, Klug, Gert, Mair, Johannes, Mayr, Agnes, Jaschke, Werner, Franz, Wolfgang-Michael, Metzler, Bernhard, Arnhold, K., Muehlberg, F., Fritschi, S., Funk, S., Prothmann, M., von Knobelsdorff-Brenkenhoff, F., Schulz-Menger, J., Lakhani, Zeeshan S. A., Mohan, B., karthik, G A., Raj, Vimal, Weir-McCall, Jonathan, Cassidy, Deirdre B, Belch, Jill JF, Gandy, Stephen J, Houston, Graeme, Lambert, Matthew A, Littleford, Roberta, Rowland, Janice, Struthers, Allan D, Khan, Faisel, Camaioni, Claudia, Salel, Marjorie, Hennig, Alexia, Corneloup, Olivier, Montaudon, Michel, Laurent, Francois, Cochet, Hubert, Kan, Rachel, Erhayiem, Bara, McDiarmid, Adam K., Garg, Pankaj, Dobson, Laura E., Musa, Tarique A., Ripley, David, Ajjan, Ramzi, Greenwood, John P., Plein, Sven, Swoboda, Peter P., Reinstadler, Sebastian J., Fuernau, Georg, Eitel, Charlotte, de Waha, Suzanne, Desch, Steffen, Metzler, Bernhard, Schuler, Gerhard, Thiele, Holger, Eitel, Ingo, Feistritzer, Hans-Josef, Reinstadler, Sebastian Johannes, Klug, Gert, Reindl, Martin, Mair, Johannes, Mayr, Agnes, Franz, Wolfgang-Michael, Metzler, Bernhard, Feistritzer, Hans-Josef, Klug, Gert, Reinstadler, Sebastian Johannes, Reindl, Martin, Mayr, Agnes, Franz, Wolfgang-Michael, Metzler, Bernhard, Festa, P., Cadoni, A., D'andrea, C., Costa, S., Keilberg, P., Lunardini, A., Ali, L. Ait, Ali, L. Ait, Aquaro, GD., Peritore, G., Ricci, F., De Marchi, D., Passino, C., Festa, P., Martínez, A. Tercero, Cuartero, J. Navarro, Soriano, J.G. Córdoba, Núñez, S. Calero, de Galarreta, T. Cros Ruiz, García, M. Villar, Page, J.C. Gallego, López, J.C. García, Ruiz, M. 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Abstract

Objectives: Myocardial fibrosis in noninfarcted myocardium is emerging as a principal phenotype of vulnerability to adverse events such as mortality and hospitalization for heart failure (HHF), but its optimal noninvasive measurement remains uncertain despite consistently robust histologic validation data for extracellular volume fraction (ECV). We therefore compared ECV, native T1, post contrast T1, the gadolinium contrast partition coefficient (lambda), and the presence of nonischemic scar in their associations with mortality and HHF outcomes. Method: To quantify of myocardial fibrosis, we performed T1 mapping (MOLLI) in basal and mid short axis slices with cardiovascular magnetic resonance (CMR) before contrast and 12-30 minutes post contrast bolus in 1185 consecutive patients without amyloidosis, hypertrophic or stress cardiomyopathy. We assessed associations with outcomes using Kaplan-Meier plots and chi square values from univariable Cox regression models. All standard T1 mapping parameters were obtained: native and post contrast myocardial T1, the partition coefficient lambda, and ECV. ECV = (1-hematocrit) · [ΔR1myocardium]/[ΔR1bloodpool], where R1 = 1/T1 Late gadolinium enhancement imaging with phase sensitive reconstruction identified nonischemic scar. Results: Over a median of 1.7 years, 111 individuals experienced events after CMR: 55 HHF events and 74 deaths. ECV yielded better separation of Kaplan-Meier curves in a dose dependent fashion (Figure) and also stronger associations with the combined endpoint of death or HHF. The ECV chi square (77.3, p < 0.001) was at least twice as large as the Native T1 chi square (37.5, p < 0.001), the lambda chi square (34.8, p < 0.001) and nonischemic scar (chi square = 20.5, p<0.001). Post-contrast T1 was not associated with outcomes, even when adjusting further for time after contrast bolus, renal function, and patient weight (chi square <3, p >0.10). Conclusion: Analogous to histologic previously published validation data, quantitative ECV myocardial fibrosis measures associated with outcomes far stronger than other surrogate measures outcome measures such as native T1, post contrast T1 and nonischemic scar on LGE images. These data suggest that ECV is the noninvasive metric of choice to measure myocardial fibrosis. Figure. Kaplan-Meier Plots for T1 mapping parameters.

Published
2016
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49. SIRM-SIAAIC consensus, an Italian document on management of patients at risk of hypersensitivity reactions to contrast media

Author

Laura Romanini, Francesco Gaeta, Matteo Passamonti, Stefano Pucci, Giovanni Cerri, Antonino Romano, Cristoforo Incorvaia, Marina Mauro, Fulvio Stacul, Mona-Rita Yacoub, Eustacchio Nettis, Rocco Luigi Valluzzi, Eleonora Savi, Michele Galluzzo, Sergio Testi, Paolo Ricci, Oliviero Rossi, Elisabetta Di Leo, Emanuele Grassedonio, Patrizia Bonadonna, Paolo Montuschi, Erminia Ridolo, Maria Teresa Costantino, Alfonso Reginelli, Costantino, M. T., Romanini, L., Gaeta, F., Stacul, F., Valluzzi, R. L., Passamonti, M., Bonadonna, P., Cerri, G., Pucci, S., Ricci, P., Savi, E., Galluzzo, M., Mauro, M., Grassedonio, E., Yacoub, M. R., Reginelli, A., Testi, S., Ridolo, E., Nettis, E., Di Leo, E., Rossi, O., Montuschi, P., Incorvaia, C., Romano, A., Costantino M.T., Romanini L., Gaeta F., Stacul F., Valluzzi R.L., Passamonti M., Bonadonna P., Cerri G., Pucci S., Ricci P., Savi E., Galluzzo M., Mauro M., Grassedonio E., Yacoub M.R., Reginelli A., Testi S., Ridolo E., Nettis E., Di Leo E., Rossi O., Montuschi P., Incorvaia C., and Romano A.

Subjects
lcsh:Immunologic diseases. Allergy, radiologic contrast media, hypersensitivity reactions, low-osmolar contrast agents, diagnosis, management, medicine.medical_specialty, Allergy, Hypersensitivity reactions, Referral, Immunology, Review, Culprit, Radiologic contrast media, 03 medical and health sciences, 0302 clinical medicine, Diagnosis, Hypersensitivity reaction, medicine, Immunology and Allergy, Medical history, In patient, Low-osmolar contrast agents, Intensive care medicine, Molecular Biology, business.industry, Low-osmolar contrast agent, medicine.disease, Management, 030228 respiratory system, Radiological weapon, Premedication, business, lcsh:RC581-607, Anaphylaxis, Diagnosi, 030215 immunology
Abstract

Hypersensitivity reactions (HRs) to contrast media (CM) can be distinguished in immune-mediated (including allergic reactions) and non-immune-mediated reactions, even if clinical manifestations could be similar. Such manifestations range from mild skin eruptions to severe anaphylaxis, making it important for radiologists to know how to identify and manage them. A panel of experts from the Società Italiana di Radiologia Medica e Interventistica (SIRM) and the Società Italiana di Allergologia, Asma e Immunologia Clinica (SIAAIC) provided a consensus document on the management of patients who must undergo radiological investigations with CM. Consensus topics included: the risk stratification of patients, the identification of the culprit CM and of a safe alternative by an allergy workup, as well as the use of premedication and the correct procedure to safely perform an elective (i.e., scheduled) or urgent examination. The most important recommendations are: (1) in all patients, a thorough medical history must be taken by the prescribing physician and/or the radiologist to identify at-risk patients; (2) in patients with hypersensitivity reactions to CM, the radiologist must consider an alternative, non-contrast imaging study with a comparable diagnostic value, or prescribe a different investigation with another class of CM; (3) if such options are not feasible, the radiologist must address at-risk patients to a reference centre for an allergy evaluation; (4) if timely referral to an allergist is not viable, it is recommended to use a CM other than the responsible one, taking into account cross-reactivity patterns; in the case of patients with histories of severe reactions, the presence of an anesthesiologist is also recommended and a premedication is suggested.

Published
2020

50. A multicenter evaluation of a deep learning software (LungQuant) for lung parenchyma characterization in COVID-19 pneumonia

Author

Camilla Scapicchio, Andrea Chincarini, Elena Ballante, Luca Berta, Eleonora Bicci, Chandra Bortolotto, Francesca Brero, Raffaella Fiamma Cabini, Giuseppe Cristofalo, Salvatore Claudio Fanni, Maria Evelina Fantacci, Silvia Figini, Massimo Galia, Pietro Gemma, Emanuele Grassedonio, Alessandro Lascialfari, Cristina Lenardi, Alice Lionetti, Francesca Lizzi, Maurizio Marrale, Massimo Midiri, Cosimo Nardi, Piernicola Oliva, Noemi Perillo, Ian Postuma, Lorenzo Preda, Vieri Rastrelli, Francesco Rizzetto, Nicola Spina, Cinzia Talamonti, Alberto Torresin, Angelo Vanzulli, Federica Volpi, Emanuele Neri, Alessandra Retico, Scapicchio, C., Chincarini, A., Ballante, E., Berta, L., Bicci, E., Bortolotto, C., Brero, F., Cabini, R.F., Cristofalo, G., Fanni, S.C., Fantacci, M.E., Figini, S., Galia, M., Gemma, P., Grassedonio, E., Lascialfari, A., Lenardi, C., Lionetti, A., Lizzi, F., Marrale, M., Midiri, M., Nardi, C., Oliva, P., Perillo, N., Postuma, I., Preda, L., Rastrelli, V., Rizzetto, F., Spina, N., Talamonti, C., Torresin, A., Vanzulli, A., Volpi, F., Neri, E., and Retico, A.

Subjects
Deep Learning, Software validation, COVID-19, Radiology, Nuclear Medicine and imaging, Tomography (x-ray computed), Lung
Abstract

Background The role of computed tomography (CT) in the diagnosis and characterization of coronavirus disease 2019 (COVID-19) pneumonia has been widely recognized. We evaluated the performance of a software for quantitative analysis of chest CT, the LungQuant system, by comparing its results with independent visual evaluations by a group of 14 clinical experts. The aim of this work is to evaluate the ability of the automated tool to extract quantitative information from lung CT, relevant for the design of a diagnosis support model. Methods LungQuant segments both the lungs and lesions associated with COVID-19 pneumonia (ground-glass opacities and consolidations) and computes derived quantities corresponding to qualitative characteristics used to clinically assess COVID-19 lesions. The comparison was carried out on 120 publicly available CT scans of patients affected by COVID-19 pneumonia. Scans were scored for four qualitative metrics: percentage of lung involvement, type of lesion, and two disease distribution scores. We evaluated the agreement between the LungQuant output and the visual assessments through receiver operating characteristics area under the curve (AUC) analysis and by fitting a nonlinear regression model. Results Despite the rather large heterogeneity in the qualitative labels assigned by the clinical experts for each metric, we found good agreement on the metrics compared to the LungQuant output. The AUC values obtained for the four qualitative metrics were 0.98, 0.85, 0.90, and 0.81. Conclusions Visual clinical evaluation could be complemented and supported by computer-aided quantification, whose values match the average evaluation of several independent clinical experts. Key points We conducted a multicenter evaluation of the deep learning-based LungQuant automated software. We translated qualitative assessments into quantifiable metrics to characterize coronavirus disease 2019 (COVID-19) pneumonia lesions. Comparing the software output to the clinical evaluations, results were satisfactory despite heterogeneity of the clinical evaluations. An automatic quantification tool may contribute to improve the clinical workflow of COVID-19 pneumonia.

Published
2023

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