1. Whole-Body MRI Surveillance of Cancer Predisposition Syndromes: Current Best Practice Guidelines for Use, Performance, and Interpretation.
- Author
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Grasparil AD 2nd, Gottumukkala RV, Greer MC, and Gee MS
- Subjects
- Female, Genetic Predisposition to Disease, Humans, Infant, Practice Guidelines as Topic, Adrenal Gland Neoplasms diagnostic imaging, Carcinoma, Adenoid Cystic diagnostic imaging, Li-Fraumeni Syndrome diagnostic imaging, Lung Neoplasms diagnostic imaging, Magnetic Resonance Imaging, Whole Body Imaging
- Abstract
OBJECTIVE. Whole-body MRI is a valuable tool in the surveillance of cancer predisposition syndromes (CPSs). Because it allows wide-FOV imaging without ionizing radiation, whole-body MRI is ideal in pediatric patients, enabling efficient assessment of different organ systems for multifocal disease. This article summarizes the use of whole-body MRI in pediatric patients with CPSs for earlier detection of malignancy, provides evidence where available, and offers guidance where lacking because of the rarity of CPSs. Protocol modifications and technique performance in specific CPSs are also considered. CONCLUSION. Whole-body MRI is the preferred imaging modality for surveillance of pediatric patients with CPSs, and the growing literature supports its importance in presymptomatic cancer detection.
- Published
- 2020
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