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6. Efficacy of anti‐seizure medications and alternative therapies (ketogenic diet, CBD, and quinidine) in KCNT1‐related epilepsy: A systematic review.

Author

Gras, Mathilde, Bearden, David, West, Justin, and Nabbout, Rima

Subjects
LITERATURE reviews, HIGH-fat diet, KETOGENIC diet, PEOPLE with epilepsy, SEIZURES (Medicine), CINCHONA alkaloids, CANNABIDIOL
Abstract

Objective: KCNT1‐related epilepsies encompass three main phenotypes: (i) epilepsy of infancy with migrating focal seizures (EIMFS), (ii) autosomal dominant or sporadic sleep‐related hypermotor epilepsy [(AD)SHE], and (iii) different types of developmental and epileptic encephalopathies (DEE). Many patients present with drug‐resistant seizures and global developmental delays. In addition to conventional anti‐seizure medications (ASM), multiple alternative therapies have been tested including the ketogenic diet (KD), cannabidiol (CBD—including Epidyolex © and other CBD derivatives) and quinidine (QUIN). We aimed to clarify the current state of the art concerning the benefits of those therapies administered to the three groups of patients. Methods: We performed a literature review on PubMed and EMBase with the keyword "KCNT1" and selected articles reporting qualitative and/or quantitative information on responses to these treatments. A treatment was considered beneficial if it improved seizure frequency and/or intensity and/or quality of life. Patients were grouped by phenotype. Results: A total of 43 studies including 197 patients were reviewed. For EIMFS patients (32 studies, 135 patients), KD resulted in benefit in 62.5% (25/40), all types of CBD resulted in benefit in 50% (6/12), and QUIN resulted in benefit in 44.6% (25/56). For (AD)SHE patients (10 studies, 32 patients), we found only one report of treatment with KD, with no benefit noted. QUIN was trialed in 8 patients with no reported benefit. For DEE patients (10 studies, 30 patients), KD resulted in benefit for 4/7, CBD for 1/2, and QUIN for 6/9. In all groups, conventional ASM are rarely reported as beneficial (in 5%–25% of patients). Significance: Ketogenic diet, CBD, and QUIN treatments appear to be beneficial in a subset of patient with drug‐resistant epilepsy. The KD and CBD are reasonable to trial in patients with KCNT1‐related epilepsy. Further studies are needed to identify optimal treatment strategies and to establish predictive response factors. Plain Language Summary: We performed an extensive review of scientific articles providing information about the therapeutic management of epilepsy in patients with epilepsy linked to a mutation in the KCNT1 gene. Conventional anti‐seizure treatments were rarely reported to be beneficial. The ketogenic diet (a medical diet with very high fat, adequate protein and very low carbohydrate intake) and cannabidiol appeared to be useful, but larger studies are needed to reach a conclusion. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Further characterisation ofARX-related disorders in females due to inherited or de novo variants

Author

Gras, Mathilde, primary, Heide, Solveig, additional, Keren, Boris, additional, Valence, Stéphanie, additional, Garel, Catherine, additional, Whalen, Sandra, additional, Jansen, Anna C, additional, Keymolen, Kathelijn, additional, Stouffs, Katrien, additional, Jennesson, Mélanie, additional, Poirsier, Céline, additional, Lesca, Gaetan, additional, Depienne, Christel, additional, Nava, Caroline, additional, Rastetter, Agnès, additional, Curie, Aurore, additional, Cuisset, Laurence, additional, Des Portes, Vincent, additional, Milh, Mathieu, additional, Charles, Perrine, additional, Mignot, Cyril, additional, and Héron, Delphine, additional

Published
2023
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16. Further characterisation of ARX-related disorders in females due to inherited or de novo variants.

Author

Gras, Mathilde, Heide, Solveig, Keren, Boris, Valence, Stéphanie, Garel, Catherine, Whalen, Sandra, Jansen, Anna C., Keymolen, Kathelijn, Stouffs, Katrien, Jennesson, Mélanie, Poirsier, Céline, Lesca, Gaetan, Depienne, Christel, Nava, Caroline, Rastetter, Agnès, Curie, Aurore, Cuisset, Laurence, Des Portes, Vincent, Milh, Mathieu, and Charles, Perrine

Abstract

The Aristaless-related homeobox (ARX) gene is located on the X chromosome and encodes a transcription factor that is essential for brain development. While the clinical spectrum of ARX-related disorders is well described in males, from X linked lissencephaly with abnormal genitalia syndrome to syndromic and non-syndromic intellectual disability (ID), its phenotypic delineation in females is incomplete. Carrier females in ARX families are usually asymptomatic, but ID has been reported in some of them, as well as in others with de novo variants. In this study, we collected the clinical and molecular data of 10 unpublished female patients with de novo ARX pathogenic variants and reviewed the data of 63 females from the literature with either de novo variants (n=10), inherited variants (n=33) or variants of unknown inheritance (n=20). Altogether, the clinical spectrum of females with heterozygous pathogenic ARX variants is broad: 42.5% are asymptomatic, 16.4% have isolated agenesis of the corpus callosum (ACC) or mild symptoms (learning disabilities, autism spectrum disorder, drug-responsive epilepsy) without ID, whereas 41% present with a severe phenotype (ie, ID or developmental and epileptic encephalopathy (DEE)). The ID/DEE phenotype was significantly more prevalent in females carrying de novo variants (75%, n=15/20) versus in those carrying inherited variants (27.3%, n=9/33). ACC was observed in 66.7% (n=24/36) of females who underwent a brain MRI. By refining the clinical spectrum of females carrying ARX pathogenic variants, we show that ID is a frequent sign in females with this X linked condition. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Liste des auteurs

Author

Adam, Philippe, primary, Allain, Jérôme, additional, Bastard, Claire, additional, Belbachir, Anissa, additional, Berthéas, Benjamin, additional, Biau, David, additional, Bonnomet, François, additional, Boudissa, Mehdi, additional, Bouthors, Charlie, additional, Common, Harold, additional, Court, Charles, additional, de Courtivron, Benoît, additional, Dao, Pierre, additional, Devos Bevernage, Bernhard, additional, Dufour, Thierry, additional, Ehlinger, Matthieu, additional, Eichler, David, additional, Fadel, Élie, additional, Favreau, Henri, additional, Fuzier, Régis, additional, Garin, Christophe, additional, Giuliano, Fabienne, additional, Gruel, Yves, additional, Gras, Mathilde, additional, Guillaume, Jean-Marc, additional, Huten, Denis, additional, Jenny, Jean-Yves, additional, Journeau, Pierre, additional, Jouve, Jean-Luc, additional, Kany, Jean, additional, Kerschbaumer, Gaël, additional, Launay, Franck, additional, Leemrijse, Thibaut, additional, Massin, Philippe, additional, Mathoulin, Christophe, additional, Mertl, Patrice, additional, Migaud, Henri, additional, Missenard, Gilles, additional, Nourissat, Geoffroy, additional, Odent, Thierry, additional, Pailhe, Régis, additional, Pasquier, Gilles-Jean-Marie, additional, Pesenti, Sébastien, additional, Putman, Sophie, additional, Rampal, Virginie, additional, Rubens-Duval, Brice, additional, Saragaglia, Dominique, additional, Seurat, Olivier, additional, Tonetti, Jérôme, additional, and Travers, Vincent, additional

Published
2019
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24. List of Contributors

Author

Buijze, Geert A., primary, Jupiter, Jesse B., additional, Arora, Rohit, additional, Bain, Gregory I., additional, Beeres, Frank J.P., additional, Bhandari, Mohit, additional, Björkman, Anders, additional, de Boer, Bastiaan N.P., additional, Botte, Michael J., additional, Brink, Peter R.G., additional, Buijze, Geert A., additional, Bulstra, Anne Eva J., additional, Casas Contreras, Raúl M., additional, Chammas, Michel, additional, Chammas, Pierre E., additional, Christopoulos, Georgios, additional, Clementson, Martin, additional, Commandeur, Joris P., additional, Coughlin, Timothy A., additional, Dias, Joseph, additional, Doornberg, Job N., additional, Drijkoningen, Tessa, additional, Duckworth, Andrew D., additional, Fernandez, Diego L., additional, Forward, Daren P., additional, Gabl, Markus, additional, Gale, Michael R., additional, Garala, Kanai, additional, Garcia-Elias, Marc, additional, Geissler, William B., additional, Goddard, Nicholas, additional, Gottschalk, Michael B., additional, Gras, Mathilde, additional, Grewal, Ruby, additional, Hannemann, Pascal F.W., additional, Haugstvedt, Jan-Ragnar, additional, Henry, Steven L., additional, Ho, Pak-Cheong, additional, Jake Hamer, M., additional, Johal, Herman, additional, Johnson, Nicholas A., additional, Jørgsholm, Peter, additional, Kakar, Sanjeev, additional, Kalb, Karlheinz, additional, Kastenberger, Tobias, additional, Khouri, Joseph S., additional, Kim, Jong-Pil, additional, Kvernmo, Hebe D., additional, Lee, Steve K., additional, Luria, Shai, additional, Mallee, Wouter H., additional, Mathoulin, Christophe L., additional, Meermans, Geert, additional, Moritomo, Hisao, additional, Moro, Jaydeep, additional, Oka, Kunihiro, additional, Ortega Hernández, Diana M., additional, Pacelli, Lorenzo L., additional, Peraut, Emmanuella, additional, Poeze, Martijn, additional, Prommersberger, Karl-Josef, additional, Rancy, Schneider K., additional, Rhemrev, Steven J., additional, Ring, David, additional, de Roo, Marieke G.A., additional, Saltzman, Eliana B., additional, Schmidle, Gernot, additional, Schmitt, Rainer, additional, Schwarcz, Yonatan, additional, Shin, Alexander Y., additional, Shivji, Faiz S., additional, Singh, Harvinder, additional, Strackee, Simon D., additional, Streekstra, Geert J., additional, Strelzow, Jason A., additional, ten Berg, Paul W., additional, Thompson, Michael A., additional, Thomsen, Niels, additional, Tse, Wing-lim, additional, Turow, Arthur, additional, Vanhees, Matthias, additional, Verstreken, Frederik, additional, de Vos, Maarten J., additional, Wolfe, Scott W., additional, and Wong, Wing-Yee C., additional

Published
2018
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26. A novel human pain insensitivity disorder caused by a point mutation in ZFHX2

Author

Habib, Abdella M, Matsuyama, Ayako, Okorokov, Andrei L, Santana-Varela, Sonia, Bras, Jose T, Aloisi, Anna Maria, Emery, Edward C, Bogdanov, Yury D, Follenfant, Maryne, Gossage, Sam J, Gras, Mathilde, Humphrey, Jack, Kolesnikov, Anna, Le Cann, Kim, Li, Shengnan, Minett, Michael S, Pereira, Vanessa, Ponsolles, Clara, Sikandar, Shafaq, Torres, Jesus M, Yamaoka, Kenji, Zhao, Jing, Komine, Yuriko, Yamamori, Tetsuo, Maniatis, Nikolas, Panov, Konstantin I, Houlden, Henry, Ramirez, Juan D, Bennett, David L H, Marsili, Letizia, Bachiocco, Valeria, Wood, John N, and Cox, James J

Published
2018
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28. Jersey finger type IV: a case report

Author

Allard, Romain and Gras, Mathilde

Abstract

Avulsion of the flexor digitorum profundus, usually known as jersey or rugby finger, is a rare condition that can only be treated surgically. It is mostly reported in sports injuries, in which the diagnosis is easily made. It is less frequent in household accidents, but should not be ignored because good results are time-dependent. Type IV jersey finger is the combination a fracture of the volar base of the distal phalanx and avulsion of the flexor digitorum profundus. This is a rare variety, and the surgical approach has not been discussed in detail. We introduce here a case report describing the clinical aspect, diagnostic approach, surgical technique and results at 6 months.

Published
2023
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32. sj-pdf-2-jhs-10.1177_17531934211027499 - Supplemental material for Hyperselective neurectomy for the treatment of upper limb spasticity in adults and children: a prospective study

Author

Leclercq, Caroline, Perruisseau-Carrier, Anne, Gras, Mathilde, Panciera, Paolo, Fulchignoni, Camillo, and Fulchignoni, Marcello

Subjects
FOS: Clinical medicine, 110323 Surgery, 110604 Sports Medicine, FOS: Health sciences, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-2-jhs-10.1177_17531934211027499 for Hyperselective neurectomy for the treatment of upper limb spasticity in adults and children: a prospective study by Caroline Leclercq, Anne Perruisseau-Carrier, Mathilde Gras, Paolo Panciera, Camillo Fulchignoni and Marcello Fulchignoni in Journal of Hand Surgery (European Volume)

Published
2021
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33. sj-pdf-1-jhs-10.1177_17531934211027499 - Supplemental material for Hyperselective neurectomy for the treatment of upper limb spasticity in adults and children: a prospective study

Author

Leclercq, Caroline, Perruisseau-Carrier, Anne, Gras, Mathilde, Panciera, Paolo, Fulchignoni, Camillo, and Fulchignoni, Marcello

Subjects
FOS: Clinical medicine, 110323 Surgery, 110604 Sports Medicine, FOS: Health sciences, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-1-jhs-10.1177_17531934211027499 for Hyperselective neurectomy for the treatment of upper limb spasticity in adults and children: a prospective study by Caroline Leclercq, Anne Perruisseau-Carrier, Mathilde Gras, Paolo Panciera, Camillo Fulchignoni and Marcello Fulchignoni in Journal of Hand Surgery (European Volume)

Published
2021
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35. Hyperselective neurectomy (HSN) in the treatment of the spastic upper limb: a prospective study

Author

Leclercq, Caroline, Perruisseau-Carrier, Anne, and Gras, Mathilde

Subjects
Neurotomy, ddc: 610, Tardieu scale, Spasticity, Selective neurectomy, 610 Medical sciences, Medicine, nervous system diseases
Abstract

Objectives/Interrogation: The goal of surgery of the spastic upper limb is to rebalance forces between spastic and contracted muscles on one side, and paralyzed or pseudo-paralyzed antagonists. Surgery for contracted muscle involves various standard techniques of muscle lengthening. The spastic[for full text, please go to the a.m. URL], 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)

Published
2020
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37. Coordinateurs

Author

Flurin, Pierre-Henri, primary, Hulet, Christophe, additional, Abadie, Pierre, additional, André, Guillaume, additional, Aïm, Florence, additional, Balestro, Jean-Christian, additional, Bessière, Charles, additional, Boileau, Pascal, additional, Bouchaïb, Julia, additional, Bouchard, Antoine, additional, Bouguennec, Nicolas, additional, Charousset, Christophe, additional, Clavert, Philippe, additional, Coudane, Henri, additional, Courage, Olivier, additional, Delagoutte, Jean-Pierre, additional, Deranlot, Julien, additional, Desmoineaux, Pierre, additional, Dréant, Nicolas, additional, Dumontier, Christian, additional, Fontès, Didier, additional, Gerometta, Antoine, additional, Gleyze, Pascal, additional, Gras, Mathilde, additional, Graveleau, Nicolas, additional, Hardy, Philipe, additional, Herzberg, Guillaume, additional, Kelbérine, François, additional, Kempf, Jean-François, additional, Lafosse, Laurent, additional, Lafosse, Thibault, additional, Mansat, Pierre, additional, Martrille, Laurent, additional, Mathoulin, Christophe, additional, Meyer, Alain, additional, Milin, Loïc, additional, Molé, Daniel, additional, Moreel, Philippe, additional, Neyton, Lionel, additional, Nourissat, Geoffroy, additional, Nové-Josserand, Laurent, additional, Roche, Olivier, additional, Seivert, Vincent, additional, Sirveaux, François, additional, Tarissi, Nicolas, additional, Versier, Gilbert, additional, and Wallach, Fabien, additional

Published
2013
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41. A novel human pain insensitivity disorder caused by a point mutation in ZFHX2

Author

Habib, Abdella M, primary, Matsuyama, Ayako, additional, Okorokov, Andrei L, additional, Santana-Varela, Sonia, additional, Bras, Jose T, additional, Aloisi, Anna Maria, additional, Emery, Edward C, additional, Bogdanov, Yury D, additional, Follenfant, Maryne, additional, Gossage, Sam J, additional, Gras, Mathilde, additional, Humphrey, Jack, additional, Kolesnikov, Anna, additional, Le Cann, Kim, additional, Li, Shengnan, additional, Minett, Michael S, additional, Pereira, Vanessa, additional, Ponsolles, Clara, additional, Sikandar, Shafaq, additional, Torres, Jesus M, additional, Yamaoka, Kenji, additional, Zhao, Jing, additional, Komine, Yuriko, additional, Yamamori, Tetsuo, additional, Maniatis, Nikolas, additional, Panov, Konstantin I, additional, Houlden, Henry, additional, Ramirez, Juan D, additional, Bennett, David L H, additional, Marsili, Letizia, additional, Bachiocco, Valeria, additional, Wood, John N, additional, and Cox, James J, additional

Published
2017
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46. Liste des auteurs et collaborateurs

Author

Abadie, Pierre, Accadbled, Franck, Almqvist, Karl Fredrik, Argenson, Jean-Noël, Aswad, Richard, Audebert, Stéphane, Aunoble, Stéphane, Bacle, Guillaume, Badet, Roger, Barbier, Olivier, Barth, Johannes, Barthélémy, Renaud, Basset, Bertrand, Batailler, Cécile, Bauer, Thomas, Bausset, Olivier, Baynat, Cécile, Beaufils, Philippe, Beaussier, Marc, Beauthier, Violaine, Bellaïche, Laurence, Berhouet, Julien, Bertani, Antoine, Besse, Jérémy, Bessière, Charles, Bienvenot, Peggy, Blamoutier, Arnaud, Bleton, Rémy, Block, Damien, Bohu, Yohann, Boileau, Pascal, Boisgard, Stéphane, Boisrenoult, Philippe, Bonin, Nicolas, Bonnevialle, Nicolas, Bonvarlet, Jean-Paul, Bouacida, Khaled, Bouchaïb, Julia, Bouguennec, Nicolas, Bouju, Yves, Bourgault, Caroline, Boussaton, Michel, Boyer, Thierry, Briole, Valérie, Buisson, Philippe, Carnesecchi, Olivier, Cassard, Xavier, Chalencon, François, Charousset, Christophe, Charrois, Olivier, Chassaing, Vincent, Chauveau, Dominique, Chauvin, Frédéric, Chotel, Franck, Chouteau, Julien, Ciais, Grégoire, Clavert, Philippe, Cognet, Jean-Michel, Collette, Michel, Collin, Philippe, Collotte, Philippe, Colombet, Philippe, Combourieu, Benoit, Cordier, Guillaume, Coudane, Henry, Courage, Olivier, Coutié, Anne-Sophie, Croutzet, Pierre, Cucurulo, Thomas, Dao-Léna, Séverine, Darcel, Véronique, Daubinet, Gilles, Dejour, David, Delangle, Florent, Delay, Cyril, Delbos, Alain, Demey, Guillaume, Descamps, Stéphane, Desmoineaux, Pierre, Determe, Patrice, Dezaly, Charles, Diesinger, Yann, Niek van Dijk, C., Djian, Patrick, Dréant, Nicolas, Dubrana, Frédéric, Dumontier, Christian, Duparc, Fabrice, Duport, Marc, Duthon, Victoria B., Ehkirch, François-Paul, Essig, Jérôme, Faivre, Bruno, Fatmy Bin Nik Mohd Najmi, Nik Mohd, Faundez, Antonio, Favard, Luc, Fayard, Jean-Marie, Flecher, Xavier, Flurin, Pierre-Henri, Fontès, Didier, Franceschi, Jean-Pierre, Garret, Jérôme, Gauthier, Morgan, Gédouin, Jean-Emmanuel, Gendre, Patrick, Gerometta, Antoine, Ghorbani, Ali, Gicquel, Philippe, Gleyze, Pascal, Godenèche, Arnaud, Golanó<ce:sup loc='post">†</ce:sup>, Pau, Gras, Mathilde, Graveleau, Nicolas, Grimaud, Olivier, Grosclaude, Sophie, Guicherd, Willaume, Guillin, Raphaël, Guillo, Stéphane, Guinand, Régis, Guinet, Virginie, Gunepin, François-Xavier, Hardy, Philippe, Herman, Serge, Herzberg, Guillaume, Hulet, Christophe, Jacquot, Adrien, Jan, Nicolas, Jenny, Jean-Yves, Jomaah, Nabil, Joudet, Thierry, Joulié, Stéphane, Jouve, Franck, Kany, Jean, Kelberine, François, Kempf, Jean-François, Khiami, Frédéric, Klouche, Shahnaz, Kovacic, Ladislav, Krantz, Nicolas, Lädermann, Alexandre, Lanternier, Hubert, Lafosse, Laurent, Lafosse, Thibault, Laffenêtre, Olivier, Landreau, Philippe, Leconiat, Yvan, Lecoq, Florane, Lefebvre, Yves, Lefevre, Nicolas, Legré-Boyer, Virginie, Le Huec, Jean-Charles, Le Moulec, Yves-Pierre, Lespagnol, Florent, Levadoux, Michel, Lévigne, Christophe, Louis, Marie-Laure, Lustig, Sébastien, Mader, Roch, Mainard, Didier, Mansat, Pierre, Martinache, Xavier, Marullo, Matteo, Mathieu, Laurent, Mathoulin, Christophe, May, Olivier, Maynou, Carlos, Menetrey, Jacques, Meyer, Alain, Michels, Frederick, Milin, Loïc, Moevi, Aristote Hans, Molé, Daniel, Mouilhade, Frédéric, Mouton, Caroline, Moyen, Bernard, Narchi, Patrick, Neyret, Philippe, Neyton, Lionel, Nogier, Alexis, Nourissat, Geoffroy, Nové-Josserand, Laurent, Oger, Philippe, Ollat, Didier, Ollivier, Matthieu, Panisset, Jean-Claude, Parratte, Sébastien, Paumier, François-Loïc, Pellet, Nicolas, Philippe, Richard, Pineau, Vincent, Pinelli, Pierre-Olivier, Plaweski, Stéphane, Potel, Jean-François, Pujol, Nicolas, Rabat, Eduard, Rathi, Ritesh, Rémy, Franck, Riera, Philippe, Robert, Henri, Robial, Nicolas, Rocha-Piedade, Sergio, Rochcongar, Goulven, Roche, Olivier, Rongiéras, Frédéric, Rontes, Olivier, Ropars, Mickael, Roure, Philippe, Rousseau, Romain, Roussignol, Xavier, Ruffieux, Étienne, Salle de Chou, Étienne, Saragaglia, Dominique, Sbihi, Abdou, Seil, Romain, Seivert, Vincent, Servien, Elvire, Sevestre, François-Xavier, Sibilla, Frédéric, Siedlecki, Cédric, Sirveaux, François, Sonnery-Cottet, Bertrand, Stiglitz, Yves, Szymanski, Christophe, Tardy, Nicolas, Tarissi, Nicolas, Thaunat, Mathieu, Theisen, Daniel, Thomazeau, Hervé, Thoreux, Patricia, Tiemtore, Roch, Trojani, Christophe, Van Damme, Geert, Vega, Jordi, Verdonk, Peter, Verdot, François-Xavier, Vernois, Joël, Versier, Gilbert, Vervoort, Thomas, Wajsfisz, Anthony, Walch, Gilles, Wallach, Fabien, Zaoui, Amine, Dorfmann, Henri, Frank, André, and Bensimon, Corine

Published
2015
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47. Liste des collaborateurs

Author

Antoni, Maxime, Apard, Thomas, Arnaout, Ahlam, Aswad, Richard, Bargoin, K., Baur, Eva-Maria, Bleton, Rémy, Bonnevialle, Nicolas, Bonvarlet, Jean-Paul, Burnier, M., Camps, Christophe, Camus, Emmanuel J., Candelier, Gilles, Carlier, Yacine, Cellier, N., Chammas, Michel, Clavert, Philippe, Cognet, Jean-Michel, Conso, Christel, Coulet, Bertrand, Coullomb, R., Croutzet, Pierre, Curings, Pierre, Dao-Léna, Séverine, Daubinet, Gilles, Keyzer, Pieter-Bastiaan De, Delclaux, Stéphanie, Delcourt, Tiphanie, Desmoineaux, Pierre, Dumontier, Philippe, Duparc, Fabrice, Durand, Alexandre, Ferrand, Mathieu, Fontès, Didier, Garret, Jérôme, Goetti, Patrick, Goorens, Chul Ki, Goubau, Jean F., Gras, Mathilde, Herzberg, Guillaume, Ho, Pak-cheong, Jager, Thomas, Kermarrec, Gwénolé, Koch, Guillaume, Kouyoumdjian, P., Laborde, Alexandre, Lenoir, Hubert, Levadoux, Michel, Loisel, Francois, Louis, Pascal, Mak, Michael Chu-kay, Mansat, Pierre, Mares, Olivier, Mathoulin, Christophe, Merlini, Lorenzo, Moscato, L., Obert, L., Pacull, Romain, Pomares, Germain, Rouleau, Dominique M., Vanmierlo, Bert, Van Overstraeten, Luc, Vidil, Anne, and Walle, M.

Published
2020
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48. Coordinateurs

Author

Flurin, Pierre-Henri, Hulet, Christophe, Abadie, Pierre, André, Guillaume, Aïm, Florence, Balestro, Jean-Christian, Bessière, Charles, Boileau, Pascal, Bouchaïb, Julia, Bouchard, Antoine, Bouguennec, Nicolas, Charousset, Christophe, Clavert, Philippe, Coudane, Henri, Courage, Olivier, Delagoutte, Jean-Pierre, Deranlot, Julien, Desmoineaux, Pierre, Dréant, Nicolas, Dumontier, Christian, Fontès, Didier, Gerometta, Antoine, Gleyze, Pascal, Gras, Mathilde, Graveleau, Nicolas, Hardy, Philipe, Herzberg, Guillaume, Kelbérine, François, Kempf, Jean-François, Lafosse, Laurent, Lafosse, Thibault, Mansat, Pierre, Martrille, Laurent, Mathoulin, Christophe, Meyer, Alain, Milin, Loïc, Molé, Daniel, Moreel, Philippe, Neyton, Lionel, Nourissat, Geoffroy, Nové-Josserand, Laurent, Roche, Olivier, Seivert, Vincent, Sirveaux, François, Tarissi, Nicolas, Versier, Gilbert, and Wallach, Fabien

Published
2013
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49. Lunate Pseudarthrosis: Our Clinical Experience.

Author

Teodonno F, Arnaout A, Merlini L, and Gras M

Abstract

Background: Lunate pseudarthrosis is a complication of lunate fractures and few cases are described in the literature. We designed a case series of lunate pseudarthrosis, to acknowledge this topic and to show our clinical experience. Methods: Four patients were included in this study. Three went through surgical treatment of lunate nonunion. Results: At 2 years' follow-up, patients had slight improvement of range of motion (ROM) and Quick-DASH score compared to preoperative measures, though two patients developed scaphocapitate, radiolunate or midcarpal osteoarthritis. The fourth patient is asymptomatic and is being followed up. Conclusions: Surgical options depend on the localization of the pseudarthrosis in the lunate. Fragment excision can be a good option when the fragment is small, preserving scapholunate (SL) stability. Caution must be taken with dorsal pole pseudarthrosis, regarding midcarpal osteoarthritis. Level of Evidence: Level IV (Therapeutic).

Published
2023
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50. Hyperselective neurectomy for the treatment of upper limb spasticity in adults and children: a prospective study.

Author

Leclercq C, Perruisseau-Carrier A, Gras M, Panciera P, Fulchignoni C, and Fulchignoni M

Subjects
Adult, Child, Denervation, Humans, Peripheral Nerves, Prospective Studies, Muscle Spasticity surgery, Upper Extremity surgery
Abstract

Hyperselective neurectomy (HSN) procedures in the spastic upper limb aim to reduce tone by excising some branches of the involved peripheral motor nerves, at the point of entry of each motor ramus into the target muscle. In this prospective study, 42 patients with upper limb spasticity were treated by HSN for the muscles of elbow flexion, forearm pronation and wrist flexion and evaluated for their short-term results (average 6 months) and long-term outcomes (average 31 months). Results at both time points showed an effective reduction of the spastic tone, with no decrease of muscle strength in the operated spastic muscles. Comparison of results between the two time points showed durability of the improvement, which remained statistically significant despite a slight relapse in spasticity. The results of HSN compare favourably with the other techniques of partial neurectomy; however, the technique requires a detailed knowledge of upper limb motor anatomy. Level of evidence: II.

Published
2021
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