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2. Current therapeutic approach of chronic kidney disease‐mineral and bone disorder.

Author

Zaimi, Maria and Grapsa, Eirini

Subjects
RENAL osteodystrophy, NON-communicable diseases, CHRONIC kidney failure, KIDNEY diseases, VITAMIN D, KIDNEY calcification
Abstract

Chronic kidney disease (CKD) has emerged as one of the leading noncommunicable diseases affecting >10% of the population worldwide. Bone and mineral disorders are a common complication among patients with CKD resulting in a poor life quality, high fracture risk, increased morbidity and cardiovascular mortality. According to Kidney Disease: Improving Global Outcomes, renal osteodystrophy refers to changes in bone morphology found in bone biopsy, whereas CKD‐mineral and bone disorder (CKD‐MBD) defines a complex of disturbances including biochemical and hormonal alterations, disorders of bone and mineral metabolism and extraskeletal calcification. As a result, the management of CKD‐MBD should focus on the aforementioned parameters, including the treatment of hyperphosphatemia, hypocalcemia, abnormal PTH and vitamin D levels. Regarding the bone fragility fractures, osteoporosis and renal osteodystrophy, which constitute the bone component of CKD‐MBD, anti‐osteoporotic agents constitute the mainstay of treatment. However, a thorough elucidation of the CKD‐MBD pathogenesis is crucial for the ideal personalized treatment approach. In this paper, we review the pathology and management of CKD‐MBD based on the current literature with special attention to recent advances. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Erythropoietin Effect on Complement Activation in Chronic Kidney Disease.

Author

Athanasiadou, Virginia, Ampelakiotou, Kleio, Grigoriou, Eirini, Psarra, Katherina, Tsirogianni, Alexandra, Valsami, Serena, Pittaras, Theodoros, Grapsa, Eirini, and Detsika, Maria G.

Subjects
COMPLEMENT activation, CHRONIC kidney failure, NATURAL immunity, CD55 antigen, T cells
Abstract

The complement system is an important part of innate immunity. Despite its known protective role, the complement system may contribute to increased inflammation and tissue injury in cases where its balanced activation is disrupted. The kidneys have been shown to be largely affected by complement dysregulation. The aim of the present study was to investigate the effect of erythropoietin administration, on the complement system, in chronic kidney disease patients. The study involved 20 patients with CKD who received erythropoietin and measurements of levels of complement factors C3a and C5a and complement regulatory proteins (CregPs) CD55, CD46, and CD59. An increase in serum C3a and C5a levels was observed in response to EPO therapy. The increase in C3a was statistically significant (p < 0.05) and concurrent with a statistically significant decrease in CD55 in CD4+ T cells (p < 0.05) and B cells (p < 0.05) and CD59 levels in CD4+ and CD8+ T cells (p < 0.05) at completion of EPO therapy compared with healthy controls. The above observations demonstrate that EPO induces complement activation in patients undergoing EPO therapy with a simultaneous restriction of CRegPs expression, thus possibly allowing the uncontrolled complement activation, which may contribute to tissue injury and disease progression. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Investigation of Social Constraints, Psychosocial Adjustment and Optimism among Dialysis Patients.

Author

Zorba, Eirini, Fasoi, Georgia, Grapsa, Eirini, Zartaloudi, Afroditi, Polikandrioti, Maria, Alikari, Victoria, Stavropoulou, Areti, Dafogianni, Chrysoula, Impis, Orchan, and Gerogianni, Georgia

Subjects
PSYCHOLOGICAL adaptation, SOCIAL adjustment, MULTIPLE regression analysis, RANK correlation (Statistics), HEMODIALYSIS patients
Abstract

Background: Social constraints are perceived as unsupportive behaviors, leading to inadequate psychosocial adjustment, while optimism can help people recover from distress and reduce any negative effects of chronic disease. The aim of this study was to investigate social constraints, psychosocial adjustment and optimism among patients on dialysis. Methods: In this study, 402 patients undergoing dialysis in Greece completed the following questionnaires: (i) the Social Constraints Scale (SCS) for the assessment of social constrains, (ii) the Psychosocial adjustment to illness scale (PAIS-SR) for the assessment of psychosocial adjustment, and (iii) the LOT-R scale for the assessment of optimism. A Mann–Whitney test was used for the comparison of continuous variables between two groups. Spearman correlation coefficients (rho) were used to explore the association of two continuous variables. Multiple linear regression analysis was used with the SCS scale. Results: Greater difficulty in psychosocial adjustment in the domestic, vocational, extended family and social environments, sexual relationships, and health care as well as greater psychological distress were significantly associated with a greater occurrence of social constraints (p < 0.001). Additionally, greater optimism was significantly associated with fewer social constraints and lower difficulty in adjusting to their disease (p < 0.001). Conclusions: Greater difficulty in all dimensions of psychosocial adjustment is associated with more social constraints, while optimism is associated with fewer social constraints and better disease adjustment. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Placental and Renal Pathways Underlying Pre-Eclampsia

Author

Andronikidi, Paraskevi Eva, primary, Orovou, Eirini, additional, Mavrigiannaki, Eleftheria, additional, Athanasiadou, Virginia, additional, Tzitiridou-Chatzopoulou, Maria, additional, Iatrakis, George, additional, and Grapsa, Eirini, additional

Published
2024
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7. Adverse Events Associated With SARS-CoV-2 Vaccination in Patients With Glomerular Diseases and the Potential Risk of Disease Reactivation

Author

Lionaki, Sophia, Kriki, Pelagia, Marinaki, Smaragdi, Gkalitsiou, Dimitra, Dounousi, Evangelia, Liakopoulos, Vassilios, Bellos, Ioannis, Vaios, Vasileios, Kalogeropoulos, Petros, Kleinaki, Zoe, Flouda, Sofia, Gkika-Zervou, Louisa, Papasotiriou, Marios, Goumenos, Dimitrios, Venetsanopoulou, Aliki, Voulgari, Paraskevi, Moustakas, Georgios, Grapsa, Eirini, Stylianou, Kostas, Panagoutsos, Stylianos, and Boletis, Ioannis

Published
2024
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8. #5946 MULTICENTER STUDY EVALUATING THE FREQUENCY OF ADVERSE EVENTS ASSOCIATED WITH THE SARS-COV2 VACCINATION AMONG PATIENTS WITH GLOMERULAR DISEASES

Author

Lionaki, Sophia, primary, Kriki, Pelagia, additional, Marinaki, Smaragdi, additional, Dounousi, Evaggelia, additional, Flouda, Sophia, additional, Fanouriakis, Antonios, additional, Liakopoulos, Vasileios, additional, Vaios, Vasileios, additional, Sardeli, Angeliki, additional, Kleinaki, Zoe, additional, Petrou, Dimitra, additional, Agoranou, Marilena, additional, Gkika-Zervou, Louisa, additional, Goumenos, Dimitrios, additional, Papasotiriou, Marios, additional, Venetsanopoulou, Aliki, additional, Voulgari, Paraskevi, additional, Grapsa, Eirini, additional, Andronikidi, E, additional, Stylianou, Konstantinos, additional, Panagoutsos, Stylianos, additional, and Boletis, Ioannis, additional

Published
2023
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9. #6193 MULTICENTER RETROSPECTIVE STUDY EVALUATING THE CLINICAL PICTURE AND OUTCOME OF THE SARS-COV2 INFECTION AMONG PATIENTS WITH GLOMERULAR DISEASES

Author

Lionaki, Sophia, primary, Marinaki, Smaragdi, additional, Katartzi, Kostantia, additional, Galitsiou, Dimitra, additional, Moustakas, George, additional, Dounousi, Eva, additional, Flouda, Sophia, additional, Boumpas, Dimitrios, additional, Liakopoulos, Vassilios, additional, Vaios, Vasileios, additional, Karagiannis, Minas, additional, Kalogeropoulos, Petros, additional, Mpintas, Christos, additional, Pantzopoulou, Evaggelia, additional, Giannakopoulos, Panagiotis, additional, Gkika-Zervou, Louiza, additional, Papasotiriou, Marios, additional, Goumenos, Dimitrios, additional, Venetsanopoulou, Aliki, additional, Voulgari, Paraskevi, additional, Grapsa, Eirini, additional, Andronikidi, E, additional, Stylianou, Konstantinos, additional, Panagoutsos, Stylianos, additional, and Boletis, Ioannis, additional

Published
2023
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12. Association Between Vaccination Status and Mortality Among Intubated Patients With COVID-19–Related Acute Respiratory Distress Syndrome

Author

Grapsa, Eirini, primary, Adamos, Georgios, additional, Andrianopoulos, Ioannis, additional, Tsolaki, Vasiliki, additional, Giannakoulis, Vassilis G., additional, Karavidas, Nikitas, additional, Giannopoulou, Vassiliki, additional, Sarri, Katerina, additional, Mizi, Eleftheria, additional, Gavrielatou, Evdokia, additional, Papathanakos, Georgios, additional, Mantzarlis, Konstantinos D., additional, Mastora, Zafeiria, additional, Magira, Eleni, additional, Koulouras, Vasilios, additional, Kotanidou, Anastasia, additional, and Siempos, Ilias I., additional

Published
2022
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17. Dialysis in the Elderly

Author

Grapsa, Eirini, Oreopoulos, Dimitrios G., Jacobs, C., editor, Kjellstrand, C. M., editor, Koch, K. M., editor, and Winchester, J. F., editor

Published
1996
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21. Lipoprotein apheresis: a Hellenic consensus on its clinical use

Author

Kolovou, Genovefa, primary, Kolovou, Vana, additional, Bilianou, Helen, additional, Goumas, Georgios, additional, Foussas, Stefanos, additional, Grapsa, Eirini, additional, Garoufi, Anastasia, additional, Karavolias, Georgios, additional, Mavrogieni, Sophie, additional, Melidonis, Andreas, additional, Milionis, Haralampos, additional, Rallidis, Loukianos, additional, Richter, Dimitris, additional, Skoumas, Ioannis, additional, Tousoulis, Dimitris, additional, Vlachopoulos, Charalambos, additional, and Liberopoulos, Evangelos, additional

Published
2021
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22. Lipoprotein apheresis: a Hellenic consensus on its clinical use

Author

Kolovou, Genovefa Kolovou, Vana Bilianou, Helen Goumas, Georgios Foussas, Stefanos Grapsa, Eirini Garoufi, Anastasia and Karavolias, Georgios Mavrogieni, Sophie Melidonis, Andreas and Milionis, Haralampos Rallidis, Loukianos Richter, Dimitris and Skoumas, Ioannis Tousoulis, Dimitris Vlachopoulos, Charalambos Liberopoulos, Evangelos

Published
2021

23. Evaluation of Pupils' Knowledge about Kidney Health

Author

Vassilikopoulos, Theodore Kalokairinou, Athena Kourlaba, Georgia and Grapsa, Eirini

Abstract

The purpose of this study was to investigate the level of renal function knowledge of primary school pupils in Greece. We conducted a cross-sectional study with a convenience sample of 220 pupils, coming from the 5th and 6th grades of general education schools. A questionnaire consisting of 11 questions was developed from scratch. However, based on an analysis of Cronbach’s alpha values obtained when individual questions were deleted, two questions were removed from the analysis, and only nine remained for analysis and participated in the calculation of the knowledge score. Moreover, the gender and daily habits of pupils regarding water consumption and frequency of urination were recorded. Pupils had a high percentage of correct knowledge about the number of kidneys (95.2%), whether a child may have problems with the kidneys (85.5%) and whether a person can survive with one kidney (68.5%). Low levels of knowledge were observed in the function and role of the kidneys (36.4%), as well as the part of the body where the kidneys are located (30.9%). The median (interquartile range (IQR)) total knowledge score was 6 (5-7), with no difference detected between genders (p = 0.135). A statistically significant difference between pupils of 5th and 6th grades was found but the difference did not seem to be clinically significant (p = 0.035). The present research demonstrates that pupils’ knowledge of renal function and the protection of their kidneys needs improvement.

Published
2021

29. Primary adrenal leiomyosarcoma: A case report

Author

Sakellariou, Maria, primary, Dellaportas, Dionysios, additional, Grapsa, Eirini, additional, Tzikanoulas, Menelaos, additional, Dellis, Athanasios, additional, Theodosopoulos, Theodosios, additional, and Nastos, Constantinos, additional

Published
2020
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32. Swift Cure of a Chronic Wound Infected With Multiresistant Staphylococcus aureus in an Elderly Patient With Stage 5 Renal Disease

Author

Kyriakopoulos, Anthony M. Grapsa, Eirini Marcinkiewicz, Janusz and Nagl, Markus

Abstract

We present a case of a 91-year-old female with stage 5 renal disease, diabetes type 2, and considerable weakness, suffering from a 2-month-old wound infected by a multiresistant Staphylococcus aureus. The wound measured 7 cm in length, 5 cm in width, and 1.5 cm in depth, having purulent white edges and exudates exceeding the size of the wound. The systemic antibiotic use was opposing to improve the patient’s clinical condition due to underlying nephrotoxicity that may have deteriorated renal failure and resistance of the infecting pathogen. The halogenated taurine (Tau) derivatives N-chlorotaurine (NCT) and N-bromotaurine (NBrT) with potent anti-inflammatory and antimicrobial efficacy were alternatively employed as combination topical treatment to provide a therapeutic solution. Each agent was applied separately with an interval of 5 minutes as a 1% spray in aqueous solution every 30 minutes during the day for 3 days. This treatment was very well tolerated and led to rapid disappearance of the purulent exudate, rapid epithelialization, and complete healing. To avoid relapse, the application was continued 4 times daily for a further 4 days. No complications occurred in the course of treatment. This case report confirms the therapeutic efficacy of NCT in chronic purulent wounds. NBrT is well tolerated, too, and can be used in combination with NCT in emergency clinical settings. Its potential as a single agent should be investigated in further studies. Advancement of wound closure by these agents proved to be life-saving for this patient. Further molecular research is needed to identify mechanisms that promote wound healing.

Published
2019

33. Caregivers of Patients on Haemodialysis

Author

Grapsa Eirini and Gerogianni Georgia

Subjects
03 medical and health sciences, 0302 clinical medicine, business.industry, 030232 urology & nephrology, Medicine, 030212 general & internal medicine, business, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Published
2018
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34. Immunosuppressive regimens based on Cyclophospamide or Calcineurin inhibitors: Comparison of their effect in the long term outcome of Primary Membranous Nephropathy

Author

Stangou, Maria, primary, Marinaki, Smaragdi, additional, Papachristou, Evangelos, additional, Kolovou, Kyriaki, additional, Sambani, Erasmia, additional, Zerbala, Synodi, additional, Papadea, Panagiota, additional, Balafa, Olga, additional, Rapsomanikis, Karolos-Pavlos, additional, Andrikos, Aimilios, additional, Manolakaki, Panagiota, additional, Papadopoulou, Dorothea, additional, Mitsopoulos, Efstathios, additional, Liakou, Helen, additional, Andronikidi, Paraskevi-Evi, additional, Choulitoudi, Vasiliki, additional, Moustakas, George, additional, Galitsiou, Dimitra, additional, Dafnis, Eugene, additional, Stylianou, Kostas, additional, Stefanidis, Ioannis, additional, Golfinopoulos, Spyridon, additional, Panagoutsos, Stylianos, additional, Tsilivigkou, Maria, additional, Papadogianakis, Apostolos, additional, Tzanakis, Ioannis, additional, Sioulis, Athanasios, additional, Vlachakos, Dimitrios, additional, Grapsa, Eirini, additional, Spaia, Sophia, additional, Kaperonis, Nikolaos, additional, Paliouras, Christos, additional, Dioudis, Christos, additional, Papoulidou, Fani, additional, Apostolou, Theofanis, additional, Iatrou, Christos, additional, Boletis, Ioannis, additional, Goumenos, Dimitrios, additional, and Papagianni, Aikaperini, additional

Published
2019
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45. Untreated newly diagnosed essential hypertension is associated with nonalcoholic fatty liver disease in a population of a hypertensive center

Author

Michopoulos,Spyros, Chouzouri,Vasiliki, Manios,Efstathios, Grapsa,Eirini, Antoniou,Zoi, Papadimitriou,Christos, Zakopoulos,Nikolaos, Dimopoulos,Athanasios-Meletios, Michopoulos,Spyros, Chouzouri,Vasiliki, Manios,Efstathios, Grapsa,Eirini, Antoniou,Zoi, Papadimitriou,Christos, Zakopoulos,Nikolaos, and Dimopoulos,Athanasios-Meletios

Abstract

Spyros Michopoulos,1 Vasiliki I Chouzouri,1 Efstathios D Manios,1 Eirini Grapsa,2 Zoi Antoniou,1 Christos A Papadimitriou,3 Nikolaos Zakopoulos,1 Athanasios-Meletios Dimopoulos1 1Department of Clinical Therapeutics, Medical School of Athens, Alexandra Hospital, Athens, Greece; 2Nephrology Department, Medical School of Athens, Aretaieio Hospital, Athens, Greece; 3Oncology Department, Medical School of Athens, Aretaieio Hospital, Athens, Greece Purpose: Recent studies have demonstrated that hypertension (HTN) is associated with nonalcoholic fatty liver disease (NAFLD) in treated hypertensive patients. The aim of this study was to investigate the association between newly diagnosed essential HTN and NAFLD in untreated hypertensive patients. Patients and methods: A consecutive series of 240 subjects (143 hypertensives and 97 normotensives), aged 30–80 years, without diabetes mellitus were enrolled in the study. Subjects with 24-hour systolic blood pressure (SBP) values ≥130 mmHg and/or diastolic BP values ≥80 mmHg were defined as hypertensives. NAFLD was defined as the presence of liver hyperechogenicity on ultrasound. Results: Body mass index (P=0.002) and essential HTN (P=0.016) were independently associated with NAFLD in the multivariate logistic regression model. Furthermore, the multivariate analysis revealed that morning SBP (P=0.044) was independently associated with NAFLD. Conclusion: Untreated, newly diagnosed essential HTN is independently associated with NAFLD. Ambulatory BP monitoring could be used for the diagnosis of essential HTN in patients with NAFLD. Keywords: ambulatory blood pressure, liver steatosis, hypertension, nonalcoholic fatty liver disease, body mass index

Published
2016

48. Microcirculatory alterations during continuous renal replacement therapy in ICU: A novel view on the ‘dialysis trauma’ concept

Author

Pipili, Chrysoula, primary, Vasileiadis, Ioannis, additional, Grapsa, Eirini, additional, Tripodaki, Elli-Sophia, additional, Ioannidou, Sophia, additional, Papastylianou, Adroula, additional, Kokkoris, Stelios, additional, Routsi, Christina, additional, Politou, Marianna, additional, and Nanas, Serafeim, additional

Published
2016
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50. Changes in skeletal muscle microcirculation after a hemodialysis session correlates with adequacy of dialysis

Author

Pipili,Chrysoula, Grapsa,Eirini, Tripodaki,Elli-Sophia, Ioannidou,Sophia, Manetos,Christos, Parisi,Maria, Nanas,Serfeim, Pipili,Chrysoula, Grapsa,Eirini, Tripodaki,Elli-Sophia, Ioannidou,Sophia, Manetos,Christos, Parisi,Maria, and Nanas,Serfeim

Abstract

Chrysoula Pipili,1 Eirini Grapsa,1 Elli-Sophia Tripodaki,1 Sophia Ioannidou,2 Christos Manetos,1 Maria Parisi,1 Serafim Nanas1 1First Critical Care Department, 2Laboratory of Biochemistry, Evangelismos General Hospital, National and Kapodistrian University of Athens, Athens, Greece Background: Monitoring of the microcirculation may add additional information in terms of improving the adequacy of hemodialysis (HD) for patients. Withdrawal of liquid and complement activation during a HD session reduces the external pressure on the microcirculation and leads to an increased dilatation of the peripheral capillaries. The purposes of this study were to assess the effect of a single HD or hemodiafiltration session on the thenar microcirculation in patients with end-stage renal disease (ESRD) with or without diabetes, investigate the possible relationship between changes in the microcirculation and adequacy of dialysis (including Kt/V and parameters indicating secondary hyperparathyroidism), and compare microcirculation measurements obtained from patients with ESRD and those from healthy controls. Methods: This pilot prospective observational study including eleven patients with ESRD on maintenance HD (nine men of mean age 73±10.5 years, ten [91%] with hypertension), nine patients with ESRD on maintenance hemodiafiltration (six men of mean age 65.5±13.2 years, five [55.5%] with diabetes and four [44.5%] with hypertension), and eight healthy volunteers. Two paired microcirculation assessments were recorded for each HD patient before and after a dialysis session. Near infrared spectroscopy and the vascular occlusion test were used to assess the microcirculation, and blood work samples were collected before and after dialysis when the pump slowed down. Results: Patients with ESRD showed an increase in thenar cell metabolism at rest after a 4-hour HD session, and changes in cell metabolism correlated with the Kt/V of the session. Pre-dialysis tiss

Published
2015

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