1. Survival and prognostic factors in patients with oral squamous cell carcinoma
- Author
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Melo Mc, Sarmento Dj, Caldas Ad, Gustavo Pina Godoy, Ferreira Ak, Carvalho Sh, Abreu Mh, Granville-Garcia Af, and Agripino Gg
- Subjects
Adult ,Oncology ,medicine.medical_specialty ,Poor prognosis ,Younger age ,Multivariate analysis ,neoplasms ,glandular and epithelial ,03 medical and health sciences ,head and neck neoplasms ,0302 clinical medicine ,Oral Cancer and Potentially malignant disorders ,Internal medicine ,follow up studies ,Cox proportional hazards regression ,Humans ,Medicine ,Basal cell ,In patient ,Stage (cooking) ,General Dentistry ,UNESCO:CIENCIAS MÉDICAS ,Survival analysis ,Retrospective Studies ,Squamous Cell Carcinoma of Head and Neck ,business.industry ,Research ,rare diseases ,030206 dentistry ,Prognosis ,stomatognathic diseases ,Otorhinolaryngology ,Carcinoma, Squamous Cell ,Mouth Neoplasms ,epidemiology ,Surgery ,business ,Brazil - Abstract
Background This study aimed to evaluate sociodemographic and clinical factors influencing overall survival (OS) in patients with oral squamous cell carcinoma (OSCC). Material and Methods Medical charts of 547 patients with OSCC from a public hospital in northeastern Brazil seen between 1999 and 2013 were evaluated. Survival analysis was performed using the Kaplan-Meier method. The influence of age, sex, ethnicity, clinical stage, anatomical location, type of treatment, and comorbidities on the patients’ prognosis was evaluated. Cox proportional hazards regression model was used to identify independent prognostic factors. Results The 5-year OS was 39%. Multivariate analysis showed that age < 40 years (HR = 2.20; 95%CI: 1.02-4.72) and a single treatment modality (HR = 1.91; 95%CI: 1.37-2.67) were associated with a poor prognosis, while early clinical stage resulted in better outcomes (HR = 0.38; 95%CI: 0.25-0.58). Conclusions OSCC patients in advanced clinical stages, diagnosed at a younger age, and submitted to a single therapeutic modality have a poorer prognosis. Key words:Head and neck cancer, oral cancer, oral squamous cell carcinoma, survival, prognosis.
- Published
- 2021