1. Schistosomicidal Effects of Moringa oleifera Seed Oil Extract on Schistosoma mansoni-Infected Mice.
- Author
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Elmalawany AM, Osman GY, Mohamed AH, Khalaf FM, and Yassien RI
- Subjects
- Animals, Mice, Schistosoma mansoni drug effects, Anthelmintics pharmacology, Anthelmintics therapeutic use, Cytokines metabolism, Schistosomicides pharmacology, Schistosomicides therapeutic use, Granuloma parasitology, Granuloma drug therapy, Female, Male, Parasite Egg Count, Praziquantel pharmacology, Praziquantel therapeutic use, Antioxidants pharmacology, Moringa oleifera chemistry, Seeds chemistry, Plant Oils pharmacology, Plant Oils therapeutic use, Schistosomiasis mansoni drug therapy, Plant Extracts pharmacology, Liver parasitology, Liver pathology, Liver drug effects
- Abstract
Schistosomiasis causes severe hepatic fibrosis, making it a global health issue. Moringa oleifera seed oil extract, which had antiparasitic, anti-inflammatory and antioxidant effects, was investigated as an alternative treatment. The 50 mice were divided into control, infected, praziquantel-treated, M. oleifera seed oil extract-treated and combined treatment groups. These treatments were examined for their effects on egg granulomas, hepatic enzymes, total protein, albumin, antioxidant enzymes and pro-inflammatory cytokines. M. oleifera seed oil and/or PZQ significantly reduced egg numbers, granuloma size and liver histopathology. M. oleifera seed oil reduced hepatic enzyme activity, increased total protein and albumin, and increased antioxidant enzyme activity while decreasing malondialdehyde. M. oleifera seed oil reduced the levels of pro-inflammatory cytokines. M. oleifera seed oil may treat schistosomiasis instead of PZQ due to its antifibrotic, immunomodulatory and schistosomicidal properties., (© 2024 John Wiley & Sons Ltd.)
- Published
- 2024
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