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Context: Arthrogenic muscle inhibition (AMI) is a common neurophysiological response to joint injury. While athletic trainers (ATs) are constantly treating patients with AMI, it is unclear how clinicians are using the available evidence to treat the condition. Objective: To investigate ATs’ general knowledge, clinical practice, and barriers for treating AMI. Methods: A cross-sectional web-based survey was utilized. The survey was distributed to a random sample of 3000 ATs from the National Athletic Trainers’ Association and through social media. 143 board certified ATs (age: 34.6 [10.3] y; experience: 11.7 [9.8] y) from various clinical settings and educational backgrounds were included in the analysis. Results: One hundred one respondents were able to correctly identify the definition of AMI. The majority of these respondents correctly reported that joint effusion (n = 95, 94.1%) and abnormal activity from joint receptors (n = 91, 90.1%) resulted in AMI. Of the 101 respondents, only 58 (57.4%) reported using disinhibitory interventions to treat AMI. The most frequently used evidence supported interventions were transcutaneous electrical nerve stimulation (n = 38, 65.5%), neuromuscular electrical stimulation (n = 33, 56.9%), and focal joint cooling (n = 25, 43.1%). The interventions used correctly most often based on current evidence were neuromuscular electrical stimulation (n = 29/33, 87.9%) and transcutaneous electrical nerve stimulation (n = 26/38, 68.4%). Overall, difficulty quantifying AMI (n = 62, 61.24%) and lack of education (n = 71, 76.2%) were most frequently perceived as barriers. Respondents that did not use disinhibitory interventions perceived lack of experience treating AMI, understanding the terminology, and access to therapeutic modalities more often than the respondents that reported using disinhibitory interventions. Conclusion: Further education about concepts and treatment about AMI is warranted for ATs. Continued understanding of ATs’ clinical practice in regard to AMI may help identify gaps in athletic training clinical education.

To determine the association between cortical activity and postural control performance changes with differing somatosensory perturbations. Healthy individuals (n = 15) performed a single-limb balance task under four conditions: baseline, unstable surface (foam), transcutaneous electrical nerve stimulation (TENS) applied to the stance-limb knee, and combined foam + TENS. Cortical activity was recorded with electroencephalography (EEG) and postural sway via triaxial force plate. EEG signals were decomposed, localized, and clustered to generate power spectral density in theta (4–7 Hz) and alpha-2 (10–12 Hz) frequency bands in anatomical clusters. Postural sway signals were analyzed with center of pressure (COP) sway metrics (e.g., area, distance, velocity). Foam increased theta power in the frontal and central clusters (d = 0.77 to 1.16), decreased alpha-2 power in bilateral motor, right parietal, and occipital clusters (d = − 0.89 to − 2.35) and increased sway area, distance, and velocity (d = 1.09–2.57) relative to baseline. Conversely, TENS decreased central theta power (d = − 0.60), but increased bilateral motor, left parietal, and occipital alpha-2 power (d = 0.51–1.40), with similar to baseline balance performance. In combination, foam + TENS attenuated sway velocity detriments and cortical activity caused by the foam condition alone. There were weak and moderate associations between percent increased central theta and occipital activity and increased sway velocity. Somatosensory perturbations changed patterns of cortical activity during a single-limb balance task in a manner suggestive of sensory re-weighting to pertinent sensory feedback. Across conditions decreased cortical activity in pre-motor and visual regions were associated with reduced sway velocity.

Runners and coaches are often interested in identifying the "ideal" running form to reduce the risk of injury and improve performance. While differences in pelvis and hip motion have been reported among adolescent female and male long-distance runners of different stages of physical maturation, the influence of sex and/or maturation on temporal-spatial parameters is unknown for adolescent runners. Adolescent runners of different stages of physical maturation (pre-, mid-, post-pubertal) completed an overground running analysis at a self-selected speed. We performed 2 × 3 ANCOVAs (covariate = running speed) to compare temporal-spatial parameters among sex and maturation groups. Pre-adolescents ran with higher cadences and shorter step lengths than mid- (

Hamstrings muscle morphology is determinant of muscle function (i.e. strength). Among individuals with ACL reconstruction (ACLR), less cross-sectional area (CSA) and volume in the ACLR-limb are associated with muscle weakness, and may contribute to lower rates of return to preinjury activity level and an increased risk for long-term sequelae. To effectively treat muscular impairments, an accurate understanding of differences in hamstrings morphology following ACLR is needed. A systematic review and meta-analysis were undertaken to describe the morphology of the hamstring muscle complex after ACLR. We searched five databases for studies evaluating the difference between hamstrings size and architecture in individuals with ACLR. Two independent reviewers assessed each paper for inclusion and quality. Means and standard deviations were extracted from each included study to allow fixed-effect size meta-analysis calculations for comparison of results. Twenty-four studies were included for final review. Eight categories of morphological outcomes were identified, and studies were grouped accordingly: (1) volume, (2) cross-sectional area (CSA), (3) muscle length, (4) muscle thickness, (5) fascicle length, (6) pennation angle, (7) fiber area, and (8) fiber type. Meta-analysis demonstrated lower hamstrings volume in the ACLR-limb in both contralateral and control group comparisons, and lower CSA, length, and thickness in the ACLR-limb in contralateral comparisons. The semitendinosus and gracilis were most profoundly impacted. Limited moderate evidence demonstrated greater biceps femoris pennation angle in the ACLR-limb. Individuals with ACLR demonstrated large deficits in semitendinosus and gracilis muscle CSA and volume in the ACLR-limb compared contralaterally, with no differences observed in the biceps femoris or semimembranosus. Clinical implications regarding assessment and treatment of individuals with ACLR are discussed.

Context The International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC) is the most frequently used patient-reported measure of subjective knee function among individuals with anterior cruciate ligament reconstruction (ACLR). Yet, due to the limitations of traditional validation approaches, whether the IKDC measures knee function as intended is unclear. Rasch analysis offers a robust validation approach, which may enhance the clinical interpretation of the IKDC. Objective To assess the psychometric properties, ability to classify health status, and relationships between the IKDC and objective measures of strength and functional performance relative to a newly proposed reduced-item instrument. Design Cross-sectional study. Setting Laboratory. Patients or Other Participants A total of 77 individuals with primary unilateral ACLR (age = 21.9 ± 7.8 years, time postsurgery = 6.2 ± 1.0 months) and 76 age-matched control individuals (age = 22.0 ± 4.2 years). Main Outcome Measure(s) Rasch analysis was used to assess the psychometric properties of the IKDC. Receiver operator characteristic curves and logistic regression were calculated to assess the accuracy of classifying participants with ACLR versus control participants. Pearson product moment and Spearman rank order correlation analyses were conducted to evaluate relationships among subjective knee function, quadriceps torque, and single-limb hop performance. Results Rasch analysis aided the development of a reduced 8-item instrument (IKDC-8), which yielded improved psychometric properties in the rating scale performance (IKDC-8 = 0, IKDC = 3 nonmonotonic “misbehaving” items), percentage of variance accounted for by 1 dimension (IKDC-8 = 71.5%, IKDC = 56.7%), and precision in item separation (IKDC-8 = 9.79, IKDC = 5.02). The IKDC was an outstanding diagnostic tool, and the IKDC-8 was excellent, correctly classifying 87.2% and 82.7% of cases, respectively. Using the Hanley-McNeil formula, we found no difference in the areas under the respective receiver operator characteristic curves. Equivalent associations between subjective and objective knee function were observed regardless of the instrument used. Conclusions We demonstrated evidence of enhanced reliability and validity for a parsimonious measure of subjective knee function. The proposed instrument reduces the number of items, increases the score interpretability as measuring a single construct, and improves the rating scale functioning while not diminishing its ability to classify participants with ACLR versus control participants or changing existing relationships with objective measures of recovery. We suggest the IKDC-8 may enhance clinical use by reducing administration time, improving the interpretation of the subjective knee function score, and clarifying functional ability.

Hamstrings neuromuscular function is a crucial component of functional movement, and changes after anterior cruciate ligament (ACL) injury contribute to risk factors for secondary injury and long-term sequelae. To effectively treat muscular impairments, an accurate understanding of hamstrings neuromuscular function in patients with ACL reconstruction (ACLR) is needed. A systematic review and meta-analysis were undertaken to describe and quantify hamstrings neuromuscular function in individuals with ACLR compared to controls. We searched PubMed, Web of Science, SPORTDiscus, CINAHL, and EBSCOhost databases in October of 2020 for studies evaluating the difference between hamstrings electromyography (EMG) between individuals with ACLR and controls. Two independent reviewers assessed each paper for inclusion and quality. Means and standard deviations were extracted from each included study to allow random-effect size (ES) meta-analysis calculations for comparison of results. Thirty-four studies were included for final review. From these, 5 categories of neuromuscular outcomes were identified, and studies were grouped accordingly: (1) muscle activation levels (EMG amplitude), (2) co-activation, (3) onset timing, (4) electromechanical delay, and (5) time-to-peak activity. Moderate to strong evidence indicates that individuals with ACLR demonstrate higher hamstrings EMG amplitude (normalized to % maximum voluntary isometric contraction) and hamstrings-to-quadriceps co-activation during gait and stair ambulation compared to controls. In addition, there was moderate evidence of longer electromechanical delay during knee flexion and greater hamstrings-to-quadriceps co-activation during knee extension compared to controls. Greater hamstrings EMG amplitude and co-activation during gait and ambulation tasks and longer electromechanical delay of the hamstrings in individuals with ACLR align with clinical impairments following ACLR and have implications for re-injury risk and long-term joint health, thus warranting attention in rehabilitation.

Differences in the excitability of motor generating neural pathways are reported following anterior cruciate ligament reconstruction (ACLR) that is associated with quadriceps dysfunction and theorized to prevent the full recovery of muscle function. The aims of this systematic review and meta-analysis were to compare quadriceps neural excitability between the involved ACLR limb, the uninvolved limb, and uninjured controls, and to determine at what time intervals these differences are present after surgery. We conducted a search of PubMed, SPORTDiscus, Embase, and Web of Science, and extracted measures assessing difference of quadriceps spinal-reflexive, corticospinal, and intracortical excitability from studies that compared (1) involved limb to the uninvolved limb, (2) involved limb to a control limb, or (3) uninvolved limb to a control limb. We stratified time at 24 months, since this represents a period of heightened risk for reinjury. A modified Downs and Black checklist and Egger’s test were used to determine the methodological quality of individual studies and risk of bias between studies. Fourteen studies comprising 611 participants (371 individuals with a history of ACLR; median time from surgery: 31.5 months; range 0.5–221.1 months) were included in the review. Overall, the involved (g = 0.60, 95% CI [0.24, 0.96]) and uninvolved (g = 0.49, 95% CI [0.00, 0.98]) limbs exhibited greater motor threshold (MT) in comparison to uninjured controls. Motor-evoked potential (MEP) amplitudes were greater in the uninvolved limb in comparison to uninjured controls (g = 0.31, 95% CI [0.03, 0.59]). Lesser intracortical inhibition was exhibited in the uninvolved limb compared to uninjured controls (g = 0.54, 95% CI [0.14, 0.93]). When stratified by time from surgery, MEP amplitudes were greater in the uninvolved limb compared to uninjured controls (g = 0.33, 95% CI [0.03, 0.63]) within the first 24 months after surgery. When evaluated more than 24 months after surgery, the involved limb exhibited greater Hoffmann reflex (H-reflex) compared to uninjured controls (g = 0.38, 95% CI [0.00, 0.77]). MT were greater in the involved limb (g = 0.93, 95% CI [− 0.01, 1.88]) and uninvolved limb (g = 0.57, 95% CI [0.13, 1.02]) compared to uninjured controls. MEP amplitudes in the involved limb were lesser compared to uninjured controls when evaluated more than 24 months after ACLR (g = -1.11, 95% CI [− 2.03, − 0.20]). The available evidence supports that there are neural excitability differences within the corticospinal tract in individuals with ACLR when compared to uninjured controls. Future research should focus further on longitudinal assessments of neural excitability prior to and following ACLR. Identifying interventions aimed to facilitate corticospinal excitability after ACLR appears to be warranted to improve quadriceps function. Registered through PROSPERO CRD42020158714.

Context: Central activation ratio (CAR) is a common outcome measure used to quantify gross neuromuscular function of the quadriceps using the superimposed burst technique, yet this outcome measure has not been validated in the gluteal musculature. Objective: To quantify gluteus medius (GMed) and gluteus maximus (GMax) CAR in a healthy population and evaluate its validity and reliability over a 1-week period. Design: Descriptive. Setting: Laboratory. Patients or Other Participants: A total of 20 healthy participants (9 males and 11 females; age 22.2 [1.4] y, height 173.4 [11.1] cm, mass 84.8 [25.8] kg) were enrolled in this study. Interventions: Participants were assessed at 2 sessions, separated by 1 week. Progressive electrical stimuli (25%, 50%, 75%, and 100%) were delivered to the GMed and GMax at rest, and 100% stimuli were delivered during progressive hip abduction and extension contractions (25%, 50%, 75%, and 100% maximal voluntary isometric contraction). Main Outcome Measures: GMed and GMax CAR, and hip abduction and hip extension maximal voluntary isometric contraction torque. Line of best fit and coefficient of determination (r2) were used to assess the relationship between torque output and CAR at varying levels of stimuli. Intraclass correlation coefficients, ICCs(3,k), were used to assess the between-session reliability. Results: GMed CAR was 96.1% (3.4%) and 96.6% (3.2%), on visits 1 and 2, respectively, whereas GMax CAR was 86.5% (7.5%) and 87.2% (10.7%) over the 2 sessions. A third-order polynomial demonstrated the best line of fit between varying superimposed burst intensities at rest for both GMed (r2 = .156) and GMax (r2 = .602). Linear relationships were observed in the CAR during progressive contractions with a maximal superimposed burst, GMed (r2 = .409) and GMax (r2 = .639). Between-session reliability was excellent for GMed CAR, ICC(3,k) = .911, and moderate for GMax CAR, ICC(3,k) = .704. Conclusion: CAR appears to be an acceptable measure of GMed and GMax neuromuscular function in healthy individuals. Gluteal CAR measurements are reliable measures over a 1-week test period.

Context Biomechanical analyses of cutting tasks have demonstrated kinematic differences associated with the noncontact knee-injury risk when the movement direction is unanticipated. Motor-motor dual tasks occur within dynamic environments and change the demand for attentional resources needed to complete athletic maneuvers, which may contribute to injury risk. Objective To investigate the influence of anticipation and motor-motor task performance on cutting biomechanics. Design Cross-sectional study. Setting Laboratory. Patients or Other Participants A total of 32 healthy, recreationally active men (age = 23.1 ± 3.6 years, height = 180.0 ± 7.0 cm, mass = 81.3 ± 17.3 kg) who self-reported regular participation in cutting sports. Intervention(s) Participants performed a 45° side-step cut on the dominant limb in a random order of conditions: anticipation (anticipated, unanticipated) and task (no ball throw, ball fake, ball throw). Main Outcome Measure(s) Triplanar trunk, hip, and knee angles were assessed throughout the stance phase using 3-dimensional motion capture. Data were analyzed using a time series of means calculated from initial contact to toe-off (0%–100%) with 90% confidence intervals. Mean differences between conditions were identified as regions of nonoverlapping confidence intervals, and those that occurred during the region of peak vertical ground reaction force (0%–25%) are presented. Results Regardless of anticipation, attending to a ball (ball throw) resulted in more trunk extension (range = 2.9°–3.7°) and less lateral trunk flexion toward the cutting direction (range = 5.2°–5.9°). Planning to attend to a ball (ball fake) resulted in less lateral trunk flexion toward the cutting direction (4.7°). During unanticipated cutting, more trunk rotation away from the cutting direction was observed when attending to a ball (range = 5.3°–7.1°). The interaction of anticipation and task had a similar influence on sagittal- and frontal-plane trunk position. Conclusions Motor-motor task performance and its interaction with anticipation induced an upright, neutral trunk position during side-step cutting, which has been associated with the risk for noncontact knee injury. Promoting task complexity during rehabilitation and injury-prevention programs may better prepare individuals to succeed when performing high-risk athletic maneuvers.

Patients with knee joint pathology present with variable muscular responses across the muscles of the lower limb and pelvis. Conventional approaches to characterizing muscle function are limited to gross strength assessments that may overlook subtle changes both in the thigh, hip and shank musculature.To describe individualized patterns of lower extremity muscle volumes in patients with knee pathologies.This was a retrospective case series performed in a University medical center. Nine patients diagnosed with meniscus tear recommended to undergo meniscectomy volunteered. Participants underwent 3.0 Tesla magnetic resonance imaging (MRI) of the lower extremities. Thirty-five MRI-derived muscle volumes were compared between limbs and expressed as percentage asymmetry. For additional context, z-scores were also calculated for mass- and height-normalized muscles and pre-determined muscle groupings relative to a normative database.There were no consistent patterns observed when considering between-limb asymmetries among all patients. The ankle musculature (dorsiflexors, plantar flexors, and invertors) was the only muscle group to be consistently smaller than normal for all patients, with the psoas major and flexor hallucis longus being the only individual muscles. The severity or chronicity of injury and presence of surgical intervention did not appear to have a clear effect on muscle volumes.Patients with a history of meniscal pathology demonstrate inconsistent patterns of lower extremity muscle volumes about the hip, knee, and ankle between limbs and in comparison to uninjured individuals. These data support the need for individualized assessment and intervention in this population.

To determine the association between cortical activity and postural control performance changes with differing somatosensory perturbations. Healthy individuals (n = 15) performed a single-limb balance task under four conditions: baseline, unstable surface (foam), transcutaneous electrical nerve stimulation (TENS) applied to the stance-limb knee, and combined foam + TENS. Cortical activity was recorded with electroencephalography (EEG) and postural sway via triaxial force plate. EEG signals were decomposed, localized, and clustered to generate power spectral density in theta (4-7 Hz) and alpha-2 (10-12 Hz) frequency bands in anatomical clusters. Postural sway signals were analyzed with center of pressure (COP) sway metrics (e.g., area, distance, velocity). Foam increased theta power in the frontal and central clusters (d = 0.77 to 1.16), decreased alpha-2 power in bilateral motor, right parietal, and occipital clusters (d = - 0.89 to - 2.35) and increased sway area, distance, and velocity (d = 1.09-2.57) relative to baseline. Conversely, TENS decreased central theta power (d = - 0.60), but increased bilateral motor, left parietal, and occipital alpha-2 power (d = 0.51-1.40), with similar to baseline balance performance. In combination, foam + TENS attenuated sway velocity detriments and cortical activity caused by the foam condition alone. There were weak and moderate associations between percent increased central theta and occipital activity and increased sway velocity. Somatosensory perturbations changed patterns of cortical activity during a single-limb balance task in a manner suggestive of sensory re-weighting to pertinent sensory feedback. Across conditions decreased cortical activity in pre-motor and visual regions were associated with reduced sway velocity.

OBJECTIVE To identify the frequency of passing return-to-activity tests after anterior cruciate ligament reconstruction (ACLR) and to investigate the influence of patient-specific factors on pass rates. We hypothesized that isolated strength tests would be most difficult to pass and that graft type would be the most influential factor. DESIGN Cross-sectional. SETTING Laboratory. PARTICIPANTS Eighty patients with a history of primary, unilateral ACLR, and 80 healthy controls participated. INTERVENTIONS Bilateral isokinetic strength, isometric strength, and single-leg hop tests were recorded during a single visit. The International Knee Documentation Committee (IKDC) Subjective Knee Evaluation measured subjective knee function, and the Tegner Activity Scale measured physical activity level. MAIN OUTCOME MEASURES Pass rates were calculated for 3 thresholds of absolute between-limb asymmetry: 0% to 10%, 11% to 15%, and 16% to 20%. Pass rates were compared by sex (male and female), graft type (patellar and hamstrings), meniscal procedure (yes and no), physical activity level (

Impaired corticomotor function arising from altered intracortical and corticospinal pathways are theorized to impede muscle recovery following anterior cruciate ligament (ACL) surgery, yet functional implications of centrally driven adaptations remain unclear. We aimed to assess relationships between quadriceps corticomotor and neuromechanical function after ACL surgery, and to compare with contralateral and control limbs. 16 individuals after primary, unilateral ACL surgery and 16 sex- and age-matched controls participated. Corticomotor function was assessed using transcranial magnetic stimulation, and quantified via active motor thresholds (AMT), short-interval intracortical inhibition (SICI), and intracortical facilitation (ICF). Neuromechanical function was quantified via electromechanical delay, early and late-phase rate of torque development (RTD0–50, RTD100–200), coefficient of variation, maximal voluntary isometric contraction (MVIC) torque, and central activation ratio. We observed significant correlations in the ACL limbs between: AMT and RTD0–50 (r = − 0.513, p = 0.031), SICI and RTD100–200 (r = 0.501, p = 0.048), AMT and SICI (r = − 0.659, p = 0.010), AMT and ICF (r = 0.579, p = 0.031), RTD0–50 and MVIC (r = 0.504, p = 0.023), and RTD100–200 and MVIC (r = 0.680, p = 0.002). The ACL limbs demonstrated higher AMT compared to controls (44.9 ± 8.4 vs. 30.1 ± 8.2%, p

Objectives To investigate whether relationships between kinesiophobia, lower extremity function, and patient-reported function differ by self-reported physical activity engagement after ACL reconstruction (ACLR). Design Cross-sectional. Setting Laboratory. Participants Seventy-seven patients with a primary, unilateral ACLR. Main outcome measures Kinesiophobia (TSK-17) was the primary outcome. Lower extremity function included quadriceps and hamstrings strength, fatigue, and hop performance. Patient-reported function included regional function (IKDC, KOOS subscales) and physical activity engagement (Godin Leisure-Time Exercise). Patients were evaluated together, then stratified by LOW and HIGH physical activity. Correlations and multiple regression analyses identified relationships between kinesiophobia and outcome measures. Results Greater kinesiophobia was associated with lesser hamstrings strength, hop performance, and patient-reported function. Greater hamstrings fatigue and lesser KOOSADL explained greater kinesiophobia in patients reporting LOW physical activity. Lesser triple hop symmetry, crossover hop distance, and IKDC explained greater kinesiophobia in patients reporting HIGH physical activity. Conclusions Greater kinesiophobia associated with worse outcomes after ACLR. Relationships differed by self-reported physical activity engagement. Interventions that improve the ability to perform knee-related activities of daily living may be appropriate to minimize the impact of fear in less active patients, while those targeting hop performance and knee-related sport activities may be better suited for more active patients.

ContextImpaired scapular kinematics are commonly reported in patients with subacromial impingement syndrome (SIS). Various therapeutic interventions designed to improve scapular kinematics and minimize pain and disability have been described in the literature. However, the short- and long-term benefits of these interventions are unclear.ObjectiveTo determine the effects of specific short- and long-term therapeutic interventions on scapular kinematics and disability in patients with SIS.Data SourcesWe searched PubMed, CINAHL, and SPORTDiscus databases from their origins to January 2018 using a combination of the key words scapular kinematics AND (shoulder dysfunction OR subacromial impingement) and conducted a manual search by reviewing the references of the identified papers.Study SelectionStudies were included if (1) preintervention and postintervention measures were available; (2) patient-reported outcomes were reported; (3) scapular kinematics measures at 90° of ascending limb elevation in the scapular plane were included; (4) SIS was diagnosed in participants or participants self-reported symptoms of SIS; (5) they were original clinical studies published in English; and (6) the sample sizes, means, and measure of variability for each group were reported.Data ExtractionSeven studies were found. Sample sizes, means, and standard deviations of scapular upward rotation, posterior tilt, and internal rotation at 90° of ascending limb elevation on the scapular plane and the Disabilities of the Arm, Shoulder and Hand scores were extracted.Data SynthesisStandardized mean differences between preintervention and postintervention measures with 95% confidence intervals (CIs) were calculated. We observed that the Disabilities of the Arm, Shoulder and Hand scores improved (mean difference = 0.85; 95% CI = 0.54, 1.16) but did not observe changes in scapular upward rotation (mean difference = −0.04; 95% CI = −0.31, 0.22), posterior tilt (mean difference = −0.09; 95% CI = −0.32, 0.15), or internal rotation (mean difference = 0.06; 95% CI = −0.19, 0.31).ConclusionsThe short- and long-term therapeutic interventions for SIS improved patient-reported outcomes but not scapular kinematics. The identified improvements in shoulder pain and function were not likely explained by changes in scapular kinematics.

Context: Gluteus medius (GMed) weakness is a common impairment seen across multiple lower-extremity pathologies. Greater GMed weakness is moderately associated with greater frontal plane motion, often termed dynamic knee valgus during functional tasks which may increase risk of lower-extremity injury. Neuromuscular electrical stimulation (NMES) superimposed to targeted muscles has emerged in clinical practice; however, NMES superimposed to the GMed in unknown. It is essential to assess the safety, credibility, and expectancy of NMES superimposed to the GMed prior to implementation in clinical practice. The objective of this study was to evaluate feasibility, safety, credibility, and expectancy of improvement with a 2-week intervention with or without NMES to the GMed in females with dynamic knee valgus. Design: Feasibility study. Methods: A total of 22 adult females with dynamic knee valgus (age = 21.8 [1.4] y, mass = 76.9 [18.8] kg, height = 1.7 [0.1] m) completed a 2-week intervention with NMES or a sham treatment superimposed to the GMed during all therapeutic exercises. Feasibility was assessed by recruitment and completion rate, while safety was assessed by the total number of adverse events. Treatment credibility and expectancy was assessed with the Credibility Expectancy Questionnaire. Mixed-measure analysis of variance were used for statistical analysis (P ≤ .05). Results: Recruitment was completed in 5 months with 100% completion rate and no adverse events. There was no difference in treatment credibility between groups (NMES = 23.7 [2.3], sham = 21.7 [3.4], P = .12); however, the NMES group demonstrated a greater expectancy score (NMES = 20.0 [3.8], sham = 15.9 [5.1], P = .045). Conclusion: Resistance training with NMES superimposed to the GMed is a feasible and safe intervention that resulted in greater expectance of success. Clinicians may consider superimposing NMES to the gluteal muscles when addressing muscle weakness in individuals with dynamic knee valgus.

Context: Lesser hip muscle strength is commonly observed in females with patellofemoral pain (PFP) compared with females without PFP and is associated with poor subjective function and single-leg squat (SLS) biomechanics. Hip muscle weakness is theorized to be related to PFP, suggesting centrally mediated muscle inhibition may influence the observed weakness. The central activation ratio (CAR) is a common metric used to quantify muscle inhibition via burst superimposition. However, gluteal inhibition has yet to be evaluated using this approach in females with PFP. The study objectives are to (1) describe gluteal activation in the context of subjective function, hip strength, and squatting biomechanics and (2) examine the relationship of gluteal activation with subjective function and squatting biomechanics in females with PFP. Design: Cross-sectional. Methods: Seven females with PFP (age = 22.8 [3.6] y; mass = 69.4 [18.0] kg; height = 1.67 [0.05] m, duration of pain = 6–96 mo) completed this study. Subjective function was assessed with the Anterior Knee Pain Scale, while fear-avoidance beliefs were assessed with the Fear-Avoidance Belief Questionnaire physical activity and work subscales. Biomechanical function was assessed with peak hip and knee angles and moments in the sagittal and frontal planes during SLS. Gluteus medius (GMed) and gluteus maximus (GMax) activation were assessed with the CAR. Descriptive statistics were calculated, and relationships between variables were assessed with Spearman rho correlations. Results: The CAR of GMed and GMax was 90.5% (8.1%) and 84.0% (6.3%), respectively. Lesser GMed CAR was strongly associated with greater hip adduction during SLS (ρ = −.775, P = .02) and greater fear-avoidance beliefs—physical activity subscale (ρ = −.764, P = .018). Conclusion: We found a wide range in GMed and GMax activation across females with PFP. Lesser GMed activation was associated with greater hip adduction during SLS and fear of physical activity, suggesting that gluteal inhibition should be assessed in patients with PFP.

Background While traditionally viewed as a beneficial adaptation to preserve stability in the presence of knee pathology, excessive muscle co-activation may be detrimental for joint health when extrapolated to repetitive movement patterns over time. Lesser hamstrings strength relative to the quadriceps (low H:Q strength ratio) may influence neuromuscular patterns about the knee, as it is reported to increase risk for lower extremity injury among healthy females. Research question Does the relationship between H:Q strength ratio and H:Q co-activation differ between sexes during walking and jogging? Methods We used a descriptive laboratory study to assess hamstrings and quadriceps strength and muscle activity patterns during the loading response of treadmill walking gait (1.34 m/s) and jogging (2.68 m/s) in healthy males (n = 11) and females (n = 12). Concentric-concentric peak isokinetic torque (60°/s) was used to derive the H:Q strength ratio, which was treated as an explanatory variable for H:Q co-activation indices (medial, lateral, composite) and constituent EMG amplitudes. Bivariate correlations (Pearson r or Spearman ρ) were used for analysis. Results In females, lesser H:Q strength ratios were associated with greater lateral co-activation (r=−.715, P = .007) and biceps femoris EMG amplitude (ρ=−.532, P = .046) during the loading response of walking gait. When controlling for sex differences in knee flexion, the relationship between lesser H:Q strength ratios and greater lateral co-activation was preserved (partial r=−.699, P = .012); yet, biceps femoris EMG was no longer correlated (partial r=−.331, P = .175). Significant relationships were not observed among male participants during walking or in either sex during jogging (all P > .05). Significance Collectively, these data provide evidence of a sex-specific neuromuscular pattern with implications for joint health. Excessive lateral co-activation may consequently promote a greater valgus moment and ligamentous strain. Future investigations would benefit from understanding the influence of hamstrings-dominant exercise programs on the neuromuscular patterns of the knee.

The International Knee Documentation Committee (IKDC) Subjective Knee Evaluation is the most frequently used patient-reported measure of subjective knee function among individuals with ACL reconstruction (ACLR). Yet, limitations with traditional validation approaches leave it unclear whether the IKDC measures knee function as intended. Rasch analysis offers a robust validation approach, which may enhance clinical interpretation of the IKDC.1) To assess the psychometric properties, 2) ability to classify health status, and 3) relationships between the IKDC and objective measures of strength and functional performance relative to a newly proposed reduced-item instrument.Cross-sectional.Laboratory.Seventy-seven individuals with primary, unilateral ACLR (21.9±7.8 years, 6.2±1.0 months post-surgery), and seventy-six age-matched controls.Rasch analysis was used to assess the psychometric properties of the IKDC. Receiver-operator-characteristic curves and logistic regression were used to assess the accuracy of classifying ACLR versus control participants. Correlations (Pearson and Spearman) were used to assess relationships between subjective knee function, quadriceps torque, and single-limb hop performance.Rasch analysis aided the development of a reduced 8-item instrument (IKDC-8), which yielded improved psychometric properties in misfit analysis, percent of variance accounted for by one dimension (IKDC-8=71.5%; IKDC=56.7%), and item reliability. The IKDC was an outstanding diagnostic tool and the IKDC-8 was excellent, correctly classifying 87.2% and 82.7% of cases, respectively. The Hanley-McNeil formula found that there was no significant difference in the areas under the respective ROC curves. Equivalent associations between subjective and objective knee function were observed regardless of instrument used.We observed evidence of enhanced reliability and validity for a parsimonious measure of subjective knee function. The proposed instrument reduces the number of items, increases score interpretability as measuring a single construct, and improves the rating scale functioning, while not significantly diminishing its ability to classify ACLR versus control participants or changing existing relationships with objective measures of recovery. We suggest the IKDC-8 may enhance clinical use by reducing administration time, improving the interpretation of the subjective knee function score, and clarifying functional ability.

Objective External focus (EF) of attention leads to improved balance performance. Consideration of the neuromodulatory effects of EF may inform its clinical utility in addressing neuroplastic impairments after musculoskeletal injuries. We aimed to determine whether electrocortical activity and balance performance changed with attentional foci that prioritized differing sensory feedback and whether changes in electrocortical activity and balance were associated. Methods Individuals who were healthy (n = 15) performed a single-limb balance task under 3 conditions: internal focus (IF), somatosensory focus [EF with a baton (EF-baton)], and visual focus [EF with a laser (EF-laser)]. Electrocortical activity and postural sway were recorded concurrently using electroencephalography and a triaxial force plate. Electroencephalographic signals were decomposed, localized, and clustered to generate power spectral density in θ and α-2 frequency bands. Postural sway signals were analyzed with center-of-pressure sway metrics (eg, area, distance, velocity) and knee angle. The relationship between percent change in clustered brain activity and task performance metrics was assessed. Results Both EF conditions resulted in increased cortical activity and improved balance performance compared to IF. EF-laser had the largest effect, demonstrating increased frontal θ power (d = 0.64), decreased central θ power (d = −0.30), and decreased bilateral motor, bilateral parietal, and occipital α-2 power (d = −1.38 to −4.27) as well as a shorter path distance (d = −0.94) and a deeper (d = 0.70) and less variable (d = −1.15) knee angle than IF. Weak to moderate associations exist between increases in cortical activity and improved balance performance (ρ = 0.405–0.584). Conclusions EF resulted in increased cortical activity associated with cognitive, motor, somatosensory, and visual processing. EF-laser, which prioritized visual feedback, had the largest and broadest effects. Changes in cortical activity resulting from EF were independently associated with improved balance performance. Impact This study demonstrates that goal-oriented attention results in functional increases in brain activity compared to internally directed self-focus. These results suggest EF may target neurophysiologic impairments and improve balance in clinical populations.

Context Patient-reported function is an important outcome in anterior cruciate ligament rehabilitation. Identifying which metrics of thigh-muscle function are indicators of normal patient-reported function can help guide treatment. Objective To identify which metrics of thigh-muscle function discriminate between patients who meet and patients who fail to meet age- and sex-matched normative values for patient-reported knee function in the first 9 months after anterior cruciate ligament reconstruction (ACLR) and establish cutoffs for these metrics by covariate subgroups. Design Cross-sectional retrospective study. Setting Laboratory. Patients or Other Participants A total of 256 patients (129 females, 128 males; age = 17.1 ± 3.0 years, height = 1.7 ± 0.1 m, mass = 74.1 ± 17.9 kg, months since surgery = 6.4 ± 1.4), 3 to 9 months after primary unilateral ACLR. Main Outcome Measure(s) We stratified the sample into dichotomous groups by the International Knee Documentation Committee (IKDC) score (IKDCMET, IKDCNOT MET) using sex- and age-matched normative values. We measured quadriceps and hamstrings isokinetic (60°/s) torque and power bilaterally. Normalized quadriceps and hamstrings peak torque (Nm/kg) and power (W/kg), limb symmetry indices (LSI, %), and hamstrings : quadriceps ratios were calculated. Logistic regression indicated which of these metrics could predict IKDC classification while controlling for age, graft type, and sex. Receiver operating characteristic curves established cutoffs for explanatory variables for both total cohort and covariate subgroups. Odds ratios (OR) determined the utility of each cutoff to discriminate IKDC status. Results Quadriceps torque LSI (≥69.4%, OR = 3.6), hamstrings torque (≥1.11 Nm/kg, OR = 2.1), and quadriceps power LSI (≥71.4%, OR = 2.0) discriminated between IKDC classification in the total cohort. Quadriceps torque LSI discriminated between IKDC classification in the patellar-tendon graft (≥61.6%, OR = 5.3), hamstrings-tendon graft (≥71.8%, OR = 10.5), and age Conclusions Quadriceps torque LSI, hamstrings torque, and quadriceps power LSI were the most useful metrics for predicting normal patient-reported knee function early after ACLR. Further, cutoff values that best predicted normal patient-reported function differed by graft type and age.

Context: Postoperative rehabilitation is critical to optimize outcomes after anterior cruciate ligament reconstruction (ACLR). However, the relationship between physical therapy (PT) and clinical outcomes is unclear. Objective: To describe PT characteristics following ACLR and to assess the relationships between PT characteristics, surgical procedure, and clinical outcomes. Design: Cross-sectional. Setting: Laboratory. Patients (or Other Participants): A total of 60 patients (31 females/29 males, age = 22.4 [9.2] y, height = 171.7 [9.9] cm, and mass = 70.2 [14.7] kg) with a history of primary unilateral ACLR (53.6% patellar tendon and 46.4% hamstring) participated. Intervention(s): Patients completed a performance assessment and rated subjective knee function prior to physician clearance (mean = 6.3 [1.3] mo postoperatively) and were contacted within 6 months of clearance to complete a PT questionnaire. Main Outcome Measures: PT questionnaire item response, knee extension maximum voluntary isometric contraction (MVIC) torque, peak isokinetic knee extension torque, single leg hop distance, and International Knee Documentation Committee were measured. Correlations assessed relationships between PT quantity and clinical outcomes. Independent t tests compared PT quantity and clinical outcomes based on return-to-sport status, readiness to return to sport, and surgical procedure. Results: Patients completed regular PT (2 d/wk, 25 wk, 58 visits) and were most likely to conclude when discharged by the therapist (68.3%). More than half (56.7%) returned to sport, yet most (73.3%) felt unready at discharge. Isokinetic torque was correlated with days of PT/week (r = .29, P = .03). Isokinetic torque and hop symmetry were reduced in patients who returned to sport (P P P Conclusions: Many patients felt unready to return to sport at PT discharge. PT frequency was associated with isokinetic torque, yet this relationship was small. Outcomes were reduced in patients who returned to sport, suggesting premature resumption of preinjury activity.

To investigate validity and between-session reliability of frontal plane trunk, hip, and knee kinematics during three functional tasks in females with patellofemoral pain (PFP).Observational.Research Laboratory.20 females with PFP (22.7 ± 3.2 years, 69.9 ± 9.2 kg, 167.7 ± 9.6 cm).Trunk, hip, and knee frontal plane peak angles during the single leg squat (SLS), drop vertical jump (DVJ), and single leg hop (SLH) kinematics were evaluated using 2-dimensional (2D) and 3-dimensional (3D) motion capture. Participants returned to the lab one week later and competed a second 2D analysis of the functional tasks. Concurrent validity was assessed by evaluating relationship between 2D and 3D frontal plane kinematics with Pearson correlations. Between-session reliability was assessed by evaluating 2D kinematics with intraclass correlation coefficients by a single assessor.Moderate to strong correlations (r = 0.55-0.76, p .05) were found for frontal plane hip kinematics during all three tasks and the trunk during the SLH. Frontal plane kinematics demonstrated good to excellent test-retest reliability for each of the three tasks, (ICC2D hip joint angles during the three functional tasks were the only valid frontal plane angles. Trunk, hip, and knee 2D frontal plane kinematics ranged between good-excellent reliability.

Purpose Restricted ankle dorsiflexion can promote aberrant biomechanics associated with risk for knee injury during dynamic activities. Attentionally focused instructions have been used to improve high-risk knee biomechanics during landing tasks. Yet, it is unknown whether attentionally focused instruction can effectively improve landing patterns in the presence of a mechanical restriction on the ankle. Therefore, our purpose was to determine whether restricting ankle dorsiflexion by use of bracing mitigated the effects of attentional foci on landing biomechanics in healthy females. Methods We used a crossover design to investigate lower extremity biomechanics in 19 healthy females between the ages of 18–35 during a series of jump-landing tasks. Participants completed 6 blocks of 3 jump-landings on separate force platforms in a randomized order based on brace condition (brace, no brace) and mode of attentional foci (neutral, internal focus [IF], external focus [EF]). Attentionally focused instructions were provided immediately prior to 3 practice jump-landings, followed by 5 test jump-landings with self-controlled feedback only. Results Ankle bracing decreased peak dorsiflexion and sagittal range of motion (ROM) (mean difference: 5.7–5.8°), and peak inversion and frontal ROM (mean difference: 2.4–3.0°). However, hip flexion ROM (mean difference: 1.8°) increased compared to the no brace condition. Regardless of ankle bracing, EF instruction increased peak hip flexion (mean difference: 4.9°) and hip flexion range of motion (mean difference: 3.8–4.6°), while decreasing peak knee valgus (mean difference: 0.8–1.0°) and knee valgus moment (mean difference: 0.04 Nm/kg). Additionally, EF instruction increased peak hip abduction to a similar degree when braced (mean difference: 3.6–4.0°) and not braced (mean difference: 2.1–2.5°). Lastly, EF instruction increased hip abduction ROM only when braced (mean difference: 2.3–2.4°), but decreased peak knee valgus power only when not braced (mean difference: 0.18 W/kg). Conclusions Our findings indicate that mechanically restricting ankle dorsiflexion does not mitigate the ability of EF instruction to enhance jump-landing performance by means of improving hip and knee biomechanics in healthy females. However, our findings suggest an improved ability to control the rate of knee valgus loading when not braced. Therefore, we conclude that EF instruction remains a viable clinical strategy to improve landing patterns in the presence of restricted ankle dorsiflexion, yet this approach may be ineffective to reduce the rate of knee joint loading.

Objective To compare inter-limb differences in hamstring strength, muscle volume, and neural activity between individuals with anterior cruciate ligament reconstruction (ACLR) and healthy controls, and to identify associations between hamstring neuromuscular function and subjective knee function. Design Cross-sectional. Setting Laboratory. Participants Eleven participants with a history of ACLR (69.45 ± 22.48 months from surgery) and eleven healthy matched controls. Main outcome measure(s) Hamstring isokinetic torque at 60 and 240°•s−1, muscle volume, and medial and lateral hamstring electromyographic (EMG) activity during a single leg hop task were all evaluated during one study visit. Percent limb-differences (%LD) were calculated between each outcome measure; greater inter-limb differences indicated greater asymmetries between limbs. The International Knee Documentation Committee (IKDC) scores were used to determine associations between subjective knee function and each outcome measure. Results Individuals with ACLR had large magnitude inter-limb differences in medial hamstring EMG (p = .04; d = 0.94), biceps femoris short head volume (p = .02; d = 1.07) and semitendinosus (p = .03; d = 1.07) volume. Lower semimembranosus volume was associated with lower IKDC scores (r = 0.754; p = .012). Conclusions We observed greater inter-limb differences in medial hamstring EMG, and semitendinosus and long head of the biceps femoris volume, which may negatively influence knee function years after ACLR.

Context Relationships between quadriceps function and patient-reported outcomes after anterior cruciate ligament reconstruction (ACLR) are variable and may be confounded by including patients at widely different time points after surgery. Understanding these relationships during the clinically relevant phases of recovery may improve our knowledge of specific factors that influence clinical outcomes. Objective To identify the relationships between quadriceps function and patient-reported outcomes in patients 2 years (late) after ACLR, including those with posttraumatic knee osteoarthritis. Design Cross-sectional study. Setting Laboratory. Patients or Other Participants A total of 72 patients after ACLR: early (n = 34, time from surgery = 9.0 ± 4.3 months), late (n = 30, time from surgery = 70.5 ± 41.6 months), or osteoarthritis (n = 8, time from surgery = 115.9 ± 110.0 months). Main Outcome Measure(s) The total Knee Injury and Osteoarthritis Outcome Score (KOOS) and Veterans RAND 12-Item Health Survey (VR-12) were used to quantify knee function and global health. Predictors of patient-reported outcomes were involved-limb and symmetry indices of quadriceps function (isokinetic strength [peak torque, total work, average power], maximum voluntary isometric contraction torque, fatigue index, central activation ratio, Hoffmann reflex, active motor threshold) and demographics (age, activity level, pain, kinesiophobia, time since surgery). Multiple linear regression analyses were used to predict KOOS and VR-12 scores in each group. Results In the early patients, knee-extensor work, active motor threshold symmetry, pain, and activity level explained 67.8% of the variance in the KOOS score (P < .001); knee-extensor work, activity level, and pain explained 53.0% of the variance in the VR-12 score (P < .001). In the late patients, age and isokinetic torque symmetry explained 28.9% of the variance in the KOOS score (P = .004). In the osteoarthritis patients, kinesiophobia and isokinetic torque explained 77.8% of the variance in the KOOS score (P = .010); activity level explained 86.4% of the variance in the VR-12 score (P = .001). Conclusions Factors of muscle function and demographics that explain patient-reported outcomes were different in patients early and late after ACLR and in those with knee osteoarthritis.

Background: Patellofemoral pain is common in the young and active populations. Nonoperative management is limited and focuses on physical therapy. Hyaluronic acid (HA) is an injectable device that has been used for the treatment of knee osteoarthritis. Hypothesis: A single injection of HA would reduce pain and improve function in patients with patellofemoral pain who had previously failed conservative management. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: A total of 86 patients with patellofemoral pain (65 females, 21 males; mean ± SD age, 27.0 ± 7.7 years; height, 168.6 ± 8.9 cm; weight, 74.6 ± 17.0 kg; body mass index, 26.2 ± 5.2 kg/m2) enrolled in this study after failing conservative management. Patients were randomly allocated to either 6 mL of HA or a sham injection. All patients were prescribed an additional home exercise program, including lower extremity strengthening and flexibility exercises, and were evaluated at 1, 3, and 6 months. Outcome assessments included patellofemoral pain assessment with a visual analog scale during a single-legged squat, KOOS (Knee injury and Osteoarthritis Outcome Score), Kujala score, Tegner activity rating, and normalized isometric knee extension strength. Group assignment was revealed after the 6-month assessment, and crossover treatment was offered to patients in the sham group who were still symptomatic. Linear mixed models were used to compare outcomes between groups and across time. Results: A total of 45 patients were randomized to HA injection and 41 to sham, with 6 patients lost to follow-up (93% follow-up rate). Patients in both groups experienced a significant reduction in visual analog pain ratings and significant improvements in all domains of the KOOS and in Kujala scores at 6 months when compared with baseline measurement ( P < .05); however, there was no significant difference between groups. There were no differences observed over time or between groups for normalized knee extension strength or Tegner activity rating ( P > .05). Conclusion: HA injection had no clinically meaningful effect on pain or functional outcomes in patients diagnosed with patellofemoral pain. Improvements were observed for both groups in patient-reported pain and function, with no change in quadriceps strength or activity rating. Registration: NCT01771952 ( ClinicalTrials.gov identifier).

To objectively compare outcomes of nonoperative management and posterior tibial tendon (PTT) transfer for peroneal nerve injury due to multiligament knee injury (MLI).Retrospective cohort study with prospective follow-up.Tertiary care institution.Ten patients with peroneal nerve injury due to MLI (5 managed nonoperatively, 5 with PTT transfer) were evaluated and a control group of 4 patients without peroneal nerve injury.Clinical examination, subjective questionnaires, and 3-D motion capture gait analysis during flat-ground walking and stair descent.The primary outcome measure was the result of gait analysis. The results of subjective questionnaires were a secondary outcome measure.Dorsiflexion was significantly reduced at initial contact and mid-late swing phase in the nonoperative cohort. The PTT transfer cohort demonstrated increased dorsiflexion at each of these time intervals compared with patients managed nonoperatively, restoring symmetry between limbs. The PTT transfer cohort demonstrated similar gait patterns to controls but tended to be more everted. Ground reaction force was increased in the uninvolved limb in the PTT transfer group during gait and step down. There were no statistically significant differences in AOFAS, FAAM, IKDC, or Lysholm results.Posterior tibial tendon transfer is an option to restore dorsiflexion and eliminate the need for an orthosis in patients with foot drop due to MLI. Gait analysis demonstrates a significant improvement in sagittal plane ankle kinematics after PTT transfer. The trade-off is subtle instability, highlighting the dynamic stability that the PTT provides.

Muscle weakness is a common impairment in females with patellofemoral pain (PFP), clinically seen in both the quadriceps and gluteal muscles. These weaknesses have been suggested to result in poor movement patterns, which results in the clinical presentation of pain due to increased stress on the patellofemoral joint. While quadriceps weakness have been identified as a risk factor for the development of PFP, prospective studies have not found gluteal muscle weakness to be a risk factor. Therefore, gluteal muscle weakness may in fact be a consequence of PFP. This muscle weakness is often combated with traditional strengthening programs. These interventions improve both short-term subjective function and improve strength, yet their relationship to long-term outcomes are less than optimal. Strength training of the gluteals also does not transition to improved movement patterns in this population. The presence of hip muscle inhibition may be the explanation for both poor long-term function and altered movement patterns. Assessment methods for muscle inhibition have been studied in the quadriceps, commonly conducted with the superimposed burst technique to calculate an activation ratio. The use of this method may be used on the gluteus medius and gluteus maximus muscles to determine if inhibition of the hip musculature is present in females with PFP. This knowledge would provide clinicians with a more complete picture of muscle dysfunction and lead to a paradigm shift in clinical treatment strategies for this chronic condition. We hypothesize that muscle inhibition is present in the gluteal muscles of females with PFP compared to healthy controls and it is associated with both decreased subjective function and longer duration of symptoms.

Purpose To investigate relationships between quadriceps strength and neural activity, and to establish a clinical threshold of corticospinal excitability able to discriminate between patients with quadriceps strength indicative of satisfactory and unsatisfactory knee function after ACLR. Methods A total of 29 patients following primary, unilateral ACL-reconstruction (11 female, 23.2 ± 8.1 years of age, 7.3 ± 2.5 months since surgery) participated. Subjective knee function was quantified using the International Knee Documentation Committee (IKDC) subjective evaluation. Peak isokinetic knee extensor torque was assessed at 90°/s. Quadriceps corticospinal excitability was quantified via active motor threshold (AMT, %2-Tesla) using transcranial magnetic stimulation during a 5% maximal voluntary isometric contraction of the quadriceps. Pearson's r correlations were used to assess the relationship between peak knee extensor torque and AMT. Receiver operating characteristic (ROC) curves were used to establish a threshold of (a) mass-normalized peak knee extensor torque to discriminate satisfactory knee function (IKDC ≥ 75.9%), and (b) AMT to discriminate quadriceps strength indicative of satisfactory knee function. Likelihood ratios (LR) and the magnitude of change in pre-post-test probability were calculated for each threshold. Results Active motor threshold was negatively correlated with mass-normalized peak knee extensor torque (r = -0.503, P = 0.005). Knee extensor torque ≥1.23 Nm/kg was an excellent discriminator of satisfactory knee function (AUC = 0.890, P = 0.002; (+)LR = 9.56). An AMT ≤50.5% was an excellent discriminator of quadriceps strength indicative of satisfactory knee function following ACLR (AUC = 0.839, P = 0.005; (+)LR = 23.75). Conclusion Lower corticospinal excitability was associated with lower quadriceps strength. An AMT above 50.5% was found to decrease the probability of having satisfactory knee strength by over 62%.

Objective To investigate the effects of nonthermal therapeutic ultrasound on quadriceps spinal reflex excitability in patients with knee joint injury. Design Double-blind, randomized controlled laboratory study with a pretest posttest design. Setting University laboratory. Participants Recreationally active volunteers with a self-reported history of diagnosed intra-articular knee joint injury and documented quadriceps dysfunction (N=30). Interventions A nonthermal ultrasound, or sham, treatment was applied to the anteromedial knee. Main Outcome Measures Hoffmann reflex measurements were recorded at baseline, immediately postintervention, and 20 minutes post-intervention. The peak Hoffmann reflex amplitude was normalized by the peak motor response (H/M ratio) measured from the vastus medialis using surface electromyography as an estimate of quadriceps motorneuron pool excitability. A repeated-measures analysis of variance was used for comparisons. Results A significant group-by-time interaction was observed for mean ( P =.016) and change ( P =.044) in H/M ratio. The ultrasound group demonstrated significantly higher mean ( P =.015) and change ( P =.028) in H/M ratio 20 minutes postintervention than did the sham ultrasound group. Conclusions Quadriceps motoneuron pool excitability was facilitated 20 minutes after a nonthermal therapeutic ultrasound treatment, and not a sham treatment. These data provide supporting evidence of the contribution of peripheral receptors in modulation of the arthrogenic response in patients with persistent quadriceps dysfunction. Future research in this area should attempt to identify optimal treatment parameters and translate them to clinical outcomes.

Background Following anterior cruciate ligament reconstruction (ACLR), patients undergo a battery of performance assessments to determine progression of return to sport activity. Rates of reinjury following ACLR are high, indicating that current assessments may not accurately identify deficits at the time point of return to sport progression. Research question To assess single-leg postural control in ACLR patients around the time point of return to sport progression and their relationships to subjective function. Study design Descriptive Laboratory Study. Methods 198 individuals (108 ACLR, 90 healthy) participated. All ACLR participants were at the time point of return to play progression. Postural stability was quantified by center of pressure (COP) average velocity measured through a straight-knee single-leg balance assessment for 10-seconds with the participant’s eyes closed. Subjective knee function was measured from the International Knee Documentation Committee (IKDC) Subjective Knee Form and the Knee Osteoarthritis Outcome Score (KOOS) subscales. Results No significant differences existed between COP average velocity between limbs (uninvolved, involved) or groups (ACLR, Healthy). As a secondary aim, no significant relationships existed between measures of subjective knee function and postural stability. Significance Individuals following ACLR demonstrate similar patterns of postural stability as healthy individuals in a straight knee single leg balance task. Single-leg balance in a straight knee position may not be sensitive enough to detect impairments and does not predict subjective function in ACLR patients at the time of return to sport progression.

Objective The flexor carpi ulnaris (FCU) and flexor digitorum superficialis (FDS) provide dynamic stabilization to the medial elbow. It remains unclear how these muscles function during progressive throwing exercises. Our objective was to compare FCU and FDS surface electromyography (sEMG) during a throwing progression. Design Crossover. Setting Laboratory. Participants Sixteen healthy males. Main outcome measures Participants completed a plyometric throw (PLYO), long-toss 50% (LT 50 ), long-toss 75% (LT 75 ), and pitch (PITCH). sEMG was synchronized with three-dimensional kinematics to assess the acceleration phase of each exercise. Peak sEMG amplitude (%MVIC) and percentage change between progressive exercises was measured. Continuous sEMG data were assessed to determine when peak activation occurred during acceleration. Results FCU activity was greater during PITCH than LT 50 , and during LT 75 than LT 50 . Percentage change was greater from LT 50 -to-LT 75 than PLYO-to-LT 50 for both muscles. PLYO and PITCH increased most during late acceleration, whereas LT 50 and LT 75 increased most during mid-acceleration. Conclusions FCU activity did not increase in a stepwise manner, and FDS remained unchanged. Each muscle demonstrated a disproportionate increase in activation during the second exercise progression (LT 50 -to-LT 75 ) compared to the first (PLYO-to-LT 50 ), suggesting that additional exercises may be required to achieve a stepwise progression relative to forearm muscle activation.

Background: Many clinicians release patients to return to activity after anterior cruciate ligament reconstruction (ACLR) based on time from surgery despite deficits in muscle strength and function. It is unclear whether symmetry or unilateral performance is the best predictor of subjective outcomes after ACLR. Purpose: To determine physical performance predictors of patient-reported outcomes after reconstruction. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 88 participants (49 males, 39 females; mean ± SD height, 174.0 ± 9.6 cm; weight, 76.1 ± 18.5 kg; age, 19.4 ± 3.7 years) who underwent primary, unilateral ACLR volunteered for this study. Participants had undergone reconstruction a mean of 6.9 ± 1.8 months (range, 5.0-14.1 months) before the study. All participants underwent strength testing as well as hop testing and then completed the International Knee Documentation Committee (IKDC) and Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaires. Stepwise linear regression models were used for symmetry and unilateral performance to identify the proportion of variance explained in the IKDC score, KOOS total score, KOOS-sport subscale, and time from surgery, as well as receiver operating characteristic (ROC) curve analyses on those variables that explained the most variance in patient-reported outcomes to determine cutoff thresholds. Results: No significant correlations were found between time from surgery and objective performance. The only significant predictors of IKDC score were single-hop limb symmetry index (LSI) and age ( R2 = 0.177) and unilateral triple-hop performance and age ( R2 = 0.228). The cutoff for single-hop symmetry was 0.92 (area under the curve [AUC], 0.703; P = .012), and the cutoff for normalized triple-hop distance was 3.93 (AUC, 0.726; P = .005). When stratified by age, the cutoff for single-hop symmetry was 0.81 (AUC, 0.721; P = .051) for younger patients (age 2 = 0.140) and normalized knee extensor power at 180 deg/s ( R2 = 0.096). When subjective outcomes were predicted based on KOOS-sport subscale, the cutoff for single-hop symmetry was 0.85 (AUC, 0.692; P = .018). Conclusion: Hopping performance is the most predictive functional variable of subjective outcomes after reconstruction. Single-hop symmetry was most important for younger patients and unilateral triple-hop distance was most important for older patients. Clinicians should consider hopping performance when making return-to-activity decisions after ACLR.

Context:After ACL reconstruction (ACLR), deficits are often assessed using a variety of functional tests, which can be time consuming. It is unknown whether these tests provide redundant or unique information.Objective:To explore relationships between components of a battery of functional tests, the Lower Extremity Assessment Protocol (LEAP) was created to aid in developing the most informative, concise battery of tests for evaluating ACLR patients.Design:Descriptive, cross-sectional.Setting:Laboratory.Participants:76 ACLR patients (6.86±3.07 months postoperative) and 54 healthy participants.Intervention:Isokinetic knee flexion and extension at 90 and 180 degrees/second, maximal voluntary isometric contraction for knee extension and flexion, single leg balance, 4 hopping tasks (single, triple, crossover, and 6-meter timed hop), and a bilateral drop vertical jump that was scored with the Landing Error Scoring System (LESS).Main Outcome Measures:Peak torque, average torque, average power, total work, fatigue indices, center of pressure area and velocity, hop distance and time, and LESS score. A series of factor analyses were conducted to assess grouping of functional tests on the LEAP for each limb in the ACLR and healthy groups and limb symmetry indices (LSI) for both groups. Correlations were run between measures that loaded on retained factors.Results:Isokinetic and isometric strength tests for knee flexion and extension, hopping, balance, and fatigue index were identified as unique factors for all limbs. The LESS score loaded with various factors across the different limbs. The healthy group LSI analysis produced more factors than the ACLR LSI analysis. Individual measures within each factor had moderate to strong correlations. Isokinetic and isometric strength, hopping, balance, and fatigue index provided unique information.Conclusions:Within each category of measures, not all tests may need to be included for a comprehensive functional assessment of ACLR patients due to the high amount of shared variance between them.