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6. ENTORNO ECONÓMICO-FINANCIERO PARA LA REAL FEDERACIÓN ESPAÑOLA DE ATLETISMO TRAS EL COVID19.

Author

Caminero-Granja, J. A., Pajares, J., Reier, A., and Echarte, M. A.

Subjects
STATISTICAL smoothing, NET worth, BUDGET, COVID-19, ATHLETICS, BUSINESS forecasting, INFORMATION theory in economics
Abstract

Copyright of Revista Iberoamericana de Ciencias de la Actividad Física y el Deporte is the property of Revista Iberoamericana de Ciencias de la Actividad Física y el Deporte and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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7. Tight Xenon Confinement in a Crystalline Sandwich-like Hydrogen-Bonded Dimeric Capsule of a Cyclic Peptide

Author

Pizzi, A, Ozores, H, Calvelo, M, Garcia-Fandino, R, Amorin, M, Demitri, N, Terraneo, G, Bracco, S, Comotti, A, Sozzani, P, Bezuidenhout, C, Metrangolo, P, Granja, J, Pizzi A., Ozores H. L., Calvelo M., Garcia-Fandino R., Amorin M., Demitri N., Terraneo G., Bracco S., Comotti A., Sozzani P., Bezuidenhout C. X., Metrangolo P., Granja J. R., Pizzi, A, Ozores, H, Calvelo, M, Garcia-Fandino, R, Amorin, M, Demitri, N, Terraneo, G, Bracco, S, Comotti, A, Sozzani, P, Bezuidenhout, C, Metrangolo, P, Granja, J, Pizzi A., Ozores H. L., Calvelo M., Garcia-Fandino R., Amorin M., Demitri N., Terraneo G., Bracco S., Comotti A., Sozzani P., Bezuidenhout C. X., Metrangolo P., and Granja J. R.

Abstract

A cyclic hexapeptide with three pyridyl moieties connected to its backbone forms a hydrogen-bonded dimer, which tightly encapsulates a single xenon atom, like a pearl in its shell. The dimer imprints its shape and symmetry to the captured xenon atom, as demonstrated by 129Xe NMR spectroscopy, single-crystal X-ray diffraction, and computational studies. The dimers self-assemble hierarchically into tubular structures to form a porous supramolecular architecture, whose cavities are filled by small molecules and gases.

Published
2019

8. GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

Author

López-Isac, E., Acosta-Herrera, M., Kerick, M., Assassi, S., Satpathy, A.T., Granja, J., Mumbach, M.R., Beretta, L., Simeón, C.P., Carreira, P., Ortego-Centeno, N., Castellvi, I., Bossini-Castillo, L., Carmona, F.D., Orozco, G., Hunzelmann, N., Distler, J.H.W., Franke, A., Lunardi, C., Moroncini, G., Gabrielli, A., de Vries-Bouwstra, J., Wijmenga, C., Koeleman, B.P.C., Nordin, A., Padyukov, L., Hoffmann-Vold, A.-M., Lie, B., Ríos, R., Callejas, J.L., Vargas-Hitos, J.A., García-Portales, R., Camps, M.T., Fernández-Nebro, A., González-Escribano, M.F., García-Hernández, F.J., Castillo, M.J., Aguirre, M.A., Gómez-Gracia, I., Fernández-Gutiérrez, B., Rodríguez-Rodríguez, L., García de la Peña, P., Vicente, E., Andreu, J.L., Fernández de Castro, M., López-Longo, F.J., Martínez, L., Fonollosa, V., Guillén, A., Espinosa, G., Tolosa, C., Pros, A., Rodríguez-Carballeira, M., Narváez, F.J., Rubio-Rivas, M., Ortiz-Santamaría, V, Madroñero, A.B., González-Gay, M.A., Díaz, B., Trapiella, L., Sousa, A., Egurbide, M.V., Fanlo-Mateo, P., Sáez-Comet, L., Díaz, F., Hernández, V, Beltrán, E., Román-Ivorra, J.A., Grau E., Alegre-Sancho, J.J., Freire, M., Blanco-García, F.J., Oreiro, N., Witte, T., Kreuter, A., Riemekasten, G., Airó P., Magro, C., Voskuyl, A.E., Vonk, M.C., Hesselstrand, R., Proudman S., Stevens, W., Nikpour, M., Zochling, J., Sahhar, J., Roddy, J., Nash, P., Tymms, K., Rischmueller, M., Lester, S., Vyse, T., Herrick, A.L., Worthington, J., Denton C.P., Allanore, Y., Brown, M.A., Radstake, T.R.D.J., Fonseca, C., Chang H.Y., Mayes, M.D., Martin, J., European Scleroderma Group, Australian Scleroderma Interest Group (ASIG), Universidad de Salamanca, Ministerio de Economía y Competitividad (España), Junta de Andalucía, Ministerio de Educación, Cultura y Deporte (España), Instituto de Salud Carlos III, Howard Hughes Medical Institute, Federal Ministry of Education and Research (Germany), Universidad de Cantabria, [López-Isac E, Acosta-Herrera M, Kerick M] Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain. [Assassi S] The University of Texas Health Science Center-Houston, Houston, USA. [Satpathy AT, Granja J] Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, USA. Howard Hughes Medical Institute, Stanford University, Stanford, USA. [Simeón CP] Servei de Medicina Interna, Vall d'Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Rheumatology, and AII - Inflammatory diseases

Subjects
0301 basic medicine, Chemistry(all), AUTOIMMUNITY, Àcids nucleics, General Physics and Astronomy, Genome-wide association study, Disease, VARIANTS, Biochemistry, ANNOTATION, 0302 clinical medicine, Phosphopantothenoylcysteine decarboxylase, Single nucleotide, Non-U.S. Gov't, lcsh:Science, skin and connective tissue diseases, características del estudio::metaanálisis [CARACTERÍSTICAS DE PUBLICACIONES], Multidisciplinary, Nucleid acid conformation, integumentary system, Research Support, Non-U.S. Gov't, High-Throughput Nucleotide Sequencing, Genètica - Tècnica, 3. Good health, Nucleic acids, Sequence analysis DNA, Medical genetics, medicine.medical_specialty, Chromatin Immunoprecipitation, GENES, Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Genome-Wide Association Study [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Science, Non-P.H.S, Single-nucleotide polymorphism, Scleroderma systemic, Computational biology, Physics and Astronomy(all), Biology, Research Support, Study Characteristics::Meta-Analysis [PUBLICATION CHARACTERISTICS], Genetic polymorphisms, enfermedades de la piel y tejido conjuntivo::enfermedades del tejido conjuntivo::esclerodermia sistémica [ENFERMEDADES], Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Functional genomics, Genome-wide association studies, Systemic sclerosis, Rheumatic diseases, CLASSIFICATION, N.I.H, 03 medical and health sciences, Research Support, N.I.H., Extramural, Diacylglycerol kinase theta, Molecular genetics, REVEALS, Journal Article, medicine, Humans, Vascular Diseases, Risk factor, Polymorphism, Genomes, GENOME-WIDE ASSOCIATION, METAANALYSIS, 030203 arthritis & rheumatology, Scleroderma, Systemic, Biochemistry, Genetics and Molecular Biology(all), Polimorfisme genètic, HUMAN-CELLS, Extramural, Bayes Theorem, General Chemistry, Sequence Analysis, DNA, Fibrosis, 030104 developmental biology, Scleroderma (Disease), Skin and Connective Tissue Diseases::Connective Tissue Diseases::Scleroderma, Systemic [DISEASES], técnicas de investigación::métodos epidemiológicos::diseño de la investigación epidemiológica::estudio de asociación genómica completa [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Nucleic Acid Conformation, VISUALIZATION, lcsh:Q, U.S. Gov't, Esclerodèrmia, Research Support, U.S. Gov't, Non-P.H.S, Metaanàlisi, Genetics and Molecular Biology(all), Genome-Wide Association Study
Abstract

Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, including 13 new risk loci. The novel associations nearly double the number of genome-wide hits reported for SSc thus far. We define 95% credible sets of less than 5 likely causal variants in 12 loci. Additionally, we identify specific SSc subtype-associated signals. Functional analysis of high-priority variants shows the potential function of SSc signals, with the identification of 43 robust target genes through HiChIP. Our results point towards molecular pathways potentially involved in vasculopathy and fibrosis, two main hallmarks in SSc, and highlight the spectrum of critical cell types for the disease. This work supports a better understanding of the genetic basis of SSc and provides directions for future functional experiments., We thank Sofia Vargas, Sonia García, and Gema Robledo for their excellent technical assistance and all the patients and control donors for their essential collaboration. We thank National DNA Bank Carlos III (University of Salamanca, Spain) that supplied part of the control DNA samples from Spain, WTCCC and EIRA Consortiums, and PopGen 2.0 network. This work was supported by Spanish Ministry of Economy and Competitiveness (grant ref. SAF2015-66761-P), Consejeria de Innovacion, Ciencia y Tecnologia, Junta de Andalucía (P12-BIO-1395), Ministerio de Educación, Cultura y Deporte through the program FPU, Juan de la Cierva fellowship (FJCI-2015-24028), Red de Investigación en Inflamación y Enfermadades Reumaticas (RIER) from Instituto de Salud Carlos III (RD16/0012/0013), and Scleroderma Research Foundation and NIH P50- HG007735 (to H.Y.C.). H.Y.C. is an Investigator of the Howard Hughes Medical Institute. PopGen 2.0 is supported by a grant from the German Ministry for Education and Research (01EY1103). M.D.M and S.A. are supported by grant DoD W81XWH-18-1- 0423 and DoD W81XWH-16-1-0296, respectively

Published
2019
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11. GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways.

Author

Vicente E., Mumbach M.R., Granja J., Beretta L., Simeon C.P., Carreira P., Ortego-Centeno N., Castellvi I., Bossini-Castillo L., Carmona F.D., Orozco G., Hunzelmann N., Distler J.H.W., Franke A., Lunardi C., Moroncini G., Gabrielli A., de Vries-Bouwstra J., Wijmenga C., Koeleman B.P.C., Nordin A., Padyukov L., Hoffmann-Vold A.-M., Lie B., Rios R., Callejas J.L., Vargas-Hitos J.A., Garcia-Portales R., Camps M.T., Fernandez-Nebro A., Gonzalez-Escribano M.F., Garcia-Hernandez F.J., Castillo M.J., Aguirre M.A., Gomez-Gracia I., Fernandez-Gutierrez B., Rodriguez-Rodriguez L., Garcia de la Pena P., Andreu J.L., Fernandez de Castro M., Lopez-Longo F.J., Martinez L., Fonollosa, Guillen A., Espinosa G., Tolosa C., Pros A., Rodriguez-Carballeira M., Narvaez F.J., Rubio-Rivas M., Ortiz-Santamaria, Madronero A.B., Gonzalez-Gay M.A., Diaz B., Trapiella L., Sousa A., Egurbide M.V., Fanlo-Mateo P., Saez-Comet L., Diaz F., Hernandez, Beltran E., Roman-Ivorra J.A., Grau E., Alegre-Sancho J.J., Freire M., Blanco-Garcia F.J., Oreiro N., Witte T., Kreuter A., Riemekasten G., Airo P., Magro C., Voskuyl A.E., Vonk M.C., Hesselstrand R., Proudman S., Stevens W., Nikpour M., Zochling J., Sahhar J., Roddy J., Nash P., Tymms K., Rischmueller M., Lester S., Vyse T., Herrick A.L., Worthington J., Denton C.P., Allanore Y., Brown M.A., Radstake T.R.D.J., Fonseca C., Chang H.Y., Mayes M.D., Martin J., Lopez-Isac E., Acosta-Herrera M., Kerick M., Assassi S., Satpathy A.T., Vicente E., Mumbach M.R., Granja J., Beretta L., Simeon C.P., Carreira P., Ortego-Centeno N., Castellvi I., Bossini-Castillo L., Carmona F.D., Orozco G., Hunzelmann N., Distler J.H.W., Franke A., Lunardi C., Moroncini G., Gabrielli A., de Vries-Bouwstra J., Wijmenga C., Koeleman B.P.C., Nordin A., Padyukov L., Hoffmann-Vold A.-M., Lie B., Rios R., Callejas J.L., Vargas-Hitos J.A., Garcia-Portales R., Camps M.T., Fernandez-Nebro A., Gonzalez-Escribano M.F., Garcia-Hernandez F.J., Castillo M.J., Aguirre M.A., Gomez-Gracia I., Fernandez-Gutierrez B., Rodriguez-Rodriguez L., Garcia de la Pena P., Andreu J.L., Fernandez de Castro M., Lopez-Longo F.J., Martinez L., Fonollosa, Guillen A., Espinosa G., Tolosa C., Pros A., Rodriguez-Carballeira M., Narvaez F.J., Rubio-Rivas M., Ortiz-Santamaria, Madronero A.B., Gonzalez-Gay M.A., Diaz B., Trapiella L., Sousa A., Egurbide M.V., Fanlo-Mateo P., Saez-Comet L., Diaz F., Hernandez, Beltran E., Roman-Ivorra J.A., Grau E., Alegre-Sancho J.J., Freire M., Blanco-Garcia F.J., Oreiro N., Witte T., Kreuter A., Riemekasten G., Airo P., Magro C., Voskuyl A.E., Vonk M.C., Hesselstrand R., Proudman S., Stevens W., Nikpour M., Zochling J., Sahhar J., Roddy J., Nash P., Tymms K., Rischmueller M., Lester S., Vyse T., Herrick A.L., Worthington J., Denton C.P., Allanore Y., Brown M.A., Radstake T.R.D.J., Fonseca C., Chang H.Y., Mayes M.D., Martin J., Lopez-Isac E., Acosta-Herrera M., Kerick M., Assassi S., and Satpathy A.T.

Abstract

Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, including 13 new risk loci. The novel associations nearly double the number of genome-wide hits reported for SSc thus far. We define 95% credible sets of less than 5 likely causal variants in 12 loci. Additionally, we identify specific SSc subtype-associated signals. Functional analysis of high-priority variants shows the potential function of SSc signals, with the identification of 43 robust target genes through HiChIP. Our results point towards molecular pathways potentially involved in vasculopathy and fibrosis, two main hallmarks in SSc, and highlight the spectrum of critical cell types for the disease. This work supports a better understanding of the genetic basis of SSc and provides directions for future functional experiments.Copyright © 2019, The Author(s).

Published
2019

12. GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

Author

Lopez-Isac, E, Acosta-Herrera, M, Kerick, M, Assassi, S, Satpathy, AT, Granja, J, Mumbach, MR, Beretta, L, Simeon, CP, Carreira, P, Ortego-Centeno, N, Castellvi, I, Bossini-Castillo, L, David Carmona, F, Orozco, G, Hunzelmann, N, Distler, JHW, Franke, A, Lunardi, C, Moroncini, G, Gabrielli, A, de Vries-Bouwstra, J, Wijmenga, C, Koeleman, BPC, Nordin, A, Padyukov, L, Hoffmann-Vold, A-M, Lie, B, Rios, R, Callejas, JL, Vargas-Hitos, JA, Garcia-Portales, R, Camps, MT, Fernandez-Nebro, A, Gonzalez-Escribano, MF, Garcia-Hernandez, FJ, Castillo, MJ, Aguirre, MA, Gomez-Gracia, I, Fernandez-Gutierrez, B, Rodriguez-Rodriguez, L, Garcia de la Pena, P, Vicente, E, Andreu, JL, Fernandez de Castro, M, Lopez-Longo, FJ, Martinez, L, Fonollosa, V, Guillen, A, Espinosa, G, Tolosa, C, Pros, A, Rodriguez-Carballeira, M, Narvaez, FJ, Rubio-Rivas, M, Ortiz-Santamaria, V, Madronero, AB, Gonzalez-Gay, MA, Diaz, B, Trapiella, L, Sousa, A, Egurbide, MV, Fanlo-Mateo, P, Saez-Comet, L, Diaz, F, Hernandez, V, Beltran, E, Roman-Ivorra, JA, Grau, E, Alegre-Sancho, JJ, Freire, M, Blanco-Garcia, FJ, Oreiro, N, Witte, T, Kreuter, A, Riemekasten, G, Airo, P, Magro, C, Voskuyl, AE, Vonk, MC, Hesselstrand, R, Proudman, S, Stevens, W, Nikpour, M, Zochling, J, Sahhar, J, Roddy, J, Nash, P, Tymms, K, Rischmueller, M, Lester, S, Vyse, T, Herrick, AL, Worthington, J, Denton, CP, Allanore, Y, Brown, MA, Radstake, TRDJ, Fonseca, C, Chang, HY, Mayes, MD, Martin, J, Lopez-Isac, E, Acosta-Herrera, M, Kerick, M, Assassi, S, Satpathy, AT, Granja, J, Mumbach, MR, Beretta, L, Simeon, CP, Carreira, P, Ortego-Centeno, N, Castellvi, I, Bossini-Castillo, L, David Carmona, F, Orozco, G, Hunzelmann, N, Distler, JHW, Franke, A, Lunardi, C, Moroncini, G, Gabrielli, A, de Vries-Bouwstra, J, Wijmenga, C, Koeleman, BPC, Nordin, A, Padyukov, L, Hoffmann-Vold, A-M, Lie, B, Rios, R, Callejas, JL, Vargas-Hitos, JA, Garcia-Portales, R, Camps, MT, Fernandez-Nebro, A, Gonzalez-Escribano, MF, Garcia-Hernandez, FJ, Castillo, MJ, Aguirre, MA, Gomez-Gracia, I, Fernandez-Gutierrez, B, Rodriguez-Rodriguez, L, Garcia de la Pena, P, Vicente, E, Andreu, JL, Fernandez de Castro, M, Lopez-Longo, FJ, Martinez, L, Fonollosa, V, Guillen, A, Espinosa, G, Tolosa, C, Pros, A, Rodriguez-Carballeira, M, Narvaez, FJ, Rubio-Rivas, M, Ortiz-Santamaria, V, Madronero, AB, Gonzalez-Gay, MA, Diaz, B, Trapiella, L, Sousa, A, Egurbide, MV, Fanlo-Mateo, P, Saez-Comet, L, Diaz, F, Hernandez, V, Beltran, E, Roman-Ivorra, JA, Grau, E, Alegre-Sancho, JJ, Freire, M, Blanco-Garcia, FJ, Oreiro, N, Witte, T, Kreuter, A, Riemekasten, G, Airo, P, Magro, C, Voskuyl, AE, Vonk, MC, Hesselstrand, R, Proudman, S, Stevens, W, Nikpour, M, Zochling, J, Sahhar, J, Roddy, J, Nash, P, Tymms, K, Rischmueller, M, Lester, S, Vyse, T, Herrick, AL, Worthington, J, Denton, CP, Allanore, Y, Brown, MA, Radstake, TRDJ, Fonseca, C, Chang, HY, Mayes, MD, and Martin, J

Abstract

Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, including 13 new risk loci. The novel associations nearly double the number of genome-wide hits reported for SSc thus far. We define 95% credible sets of less than 5 likely causal variants in 12 loci. Additionally, we identify specific SSc subtype-associated signals. Functional analysis of high-priority variants shows the potential function of SSc signals, with the identification of 43 robust target genes through HiChIP. Our results point towards molecular pathways potentially involved in vasculopathy and fibrosis, two main hallmarks in SSc, and highlight the spectrum of critical cell types for the disease. This work supports a better understanding of the genetic basis of SSc and provides directions for future functional experiments.

Published
2019

13. GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways.

Author

Universidad de Salamanca, Ministerio de Economía y Competitividad (España), Junta de Andalucía, Ministerio de Educación, Cultura y Deporte (España), Instituto de Salud Carlos III, Howard Hughes Medical Institute, Federal Ministry of Education and Research (Germany), López-Isac, Elena, Acosta-Herrera, Marialbert, Kerick M, Assassi, S., Satpathy AT, Granja J, Mumbach, Maxwell R., Beretta L, Simeón, Carmen P., Carreira P, Ortego-Centeno, N., Castellví, I., Bossini-Castillo, L., Carmona, F.D., Orozco, Gisela, Hunzelmann, Nicolas, Distler, J.H.W., Franke, Andre, Lunardi, C., Moroncini, G, Gabrielli, Armando, de Vries-Bouwstra, Jeska, Wijmenga, C, Koeleman, B. P., Nordin, A, Padyukov, L, Hoffmann-Vold, A. M., Lie, B, European Scleroderma Group¿, Proudman, S, Stevens, W, Nikpour, M, Australian Scleroderma Interest Group (ASIG), Vyse, T, Herrick, Ariane L., Worthington, J, Denton, CP, Allanore, Y, Brown, MA, Radstake, Timothy R. D. J., Fonseca, C., Chang, HY, Mayes, Maureen D., Martín, J., Universidad de Salamanca, Ministerio de Economía y Competitividad (España), Junta de Andalucía, Ministerio de Educación, Cultura y Deporte (España), Instituto de Salud Carlos III, Howard Hughes Medical Institute, Federal Ministry of Education and Research (Germany), López-Isac, Elena, Acosta-Herrera, Marialbert, Kerick M, Assassi, S., Satpathy AT, Granja J, Mumbach, Maxwell R., Beretta L, Simeón, Carmen P., Carreira P, Ortego-Centeno, N., Castellví, I., Bossini-Castillo, L., Carmona, F.D., Orozco, Gisela, Hunzelmann, Nicolas, Distler, J.H.W., Franke, Andre, Lunardi, C., Moroncini, G, Gabrielli, Armando, de Vries-Bouwstra, Jeska, Wijmenga, C, Koeleman, B. P., Nordin, A, Padyukov, L, Hoffmann-Vold, A. M., Lie, B, European Scleroderma Group¿, Proudman, S, Stevens, W, Nikpour, M, Australian Scleroderma Interest Group (ASIG), Vyse, T, Herrick, Ariane L., Worthington, J, Denton, CP, Allanore, Y, Brown, MA, Radstake, Timothy R. D. J., Fonseca, C., Chang, HY, Mayes, Maureen D., and Martín, J.

Abstract

Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, including 13 new risk loci. The novel associations nearly double the number of genome-wide hits reported for SSc thus far. We define 95% credible sets of less than 5 likely causal variants in 12 loci. Additionally, we identify specific SSc subtype-associated signals. Functional analysis of high-priority variants shows the potential function of SSc signals, with the identification of 43 robust target genes through HiChIP. Our results point towards molecular pathways potentially involved in vasculopathy and fibrosis, two main hallmarks in SSc, and highlight the spectrum of critical cell types for the disease. This work supports a better understanding of the genetic basis of SSc and provides directions for future functional experiments.

Published
2019

16. The addition of fermented milk with plant sterols improves the adherence to lifestyle changes in hypercholesterolemic patients. The RECIPE study

Author

Masana L., Lagares M., Pinto X., Reinares L., Zuniga M., Descamps O., Bosi E., Allaert F. A., Chapman J., Bruckert E., Hernandez T., Martin C., Gomes H., Perez P. J., Gil E. M., Moro A., Jorda M. D., Lopez J. L., Alba M., Bilbao I., Alustiza M. R., Aliaga M., Munoz J. G., Terol A. M., Gomez P., Marcos M. A., Gonzalez M., Rodriguez M. J., Lopez M. V., Romero M. A., Puyo N., Egido J. F., Monreal I., Ramirez A., Madariaga M. A., De Miguel M. C., Lorda A., Munoz G., Moreno I. M., Martinez A., Sanchez A., Espino A., Gonzalez. F. J., Pracht C., Ocana C., Pena M. A., Domingo C., Gilaberte M. T., Garcia C., Diez J. A., Fornes F. V., Gutierrez M. D., Macarra E., Bugella J. I., Del. J. M., Bravo A., Becerra M. J., Carbonell C., De Miguel M., Perez A., Martin A., Romero J., Gonzalez P., Iglesias A., Lopez B., Villalonga G., Carvajal P., Marin C., Cardona F., Gonzalez A., Fernandez G., Gomez D., Sanchez C. L., Viveros D., De Lucas M. G., Marin J. M., Osorno J., Pumares C., Gimenez R., Latorre J., Barreiro M. C., Villanueva J. R., Lopez J. A., Balaguer I., Baron J., Espuga M., Firas R., Trias F., Moran A., Velasco V., Vazquez F., Hernando A., Manzanares A., Abad J. L., Peraferrer M., Obarrio A., Alonso M. L., Gomez L., Roca J., Ayus B. E., Urban F., Gonzalez E., Masegosa C., Barrilero E., Jimenez M. C., Carratala M. M., Petitbo D., Ferrandiz J., Mialdea M. J., Montoro J., Muncharaz M. E., Shehchar A., De Paula L., Cano A., Sanchez L., Perez J., Alarcon C., Martinez J. F., Garrido T., Martinez F., Gomariz I., Caparros M., Kseibi T., Palomo L., Jimenez T., Luque I., Villar P., Gonzalez J. J., Aparicio J., Jimenez O., Munoz J. J., Baez F., Marcos M. P., Gonzalez T., Estevez J. A., Garcia J., Ajuria-Gogeasko S., Cabrera M., Manzano J. M., Segura G., Abat X., Yanovsky N., Borrachero J. M., Fortuny M., Martinez M. D., Gutierrez A. R., Najem N., Romero M. C., Martin S., Valverde R. J., Molina C., Martinez B., Izquierdo L., Vazquez I., Martinez M. T., Mateos A., Quiles F., Aranda F. J., Iborra R., Valero A. B., Fornes M. T., Quinza V., Colado F., Arribas B., Martinez J. E. L., Garces M. P., Valero J. M., Frigola J. L., Rubio J. M., Gongora A., Triana J., Gomez C., Garcia M. L., Diez C., Pombo G., Gutierrez M. C., Nazara C. A., De Oca M. A., Maquieira N., Pilo A., Buenadicha J. L., Duran F., Pena J. E., Navarro S., Serrano F. J., Sanchez S., Mesa S., Salazar J. A., De La Escosura A., Perez F., Solera J., Tarraga P., Ramos L., Gutierrez J. A., Caldelas S., Albinana F., Lopez J. F., Florian J., Rocha E., Rodriguez J., Mellado M. L., Calvillo M. R., Cruz T., Capitan M., Diaz J., Tome J., Prieto A., Tome V., Caro M., Montero A., Ontoria M., Garcia D. L., Gil F., De Zarate V., Casaponsa J., Matamala J., Salvande A., Trueba M. A., Cidra J. L., Garcia A., Toro A., Berna J. R., Zornoza B., Prieto M. T., Garcia L., Lopez C., Garcia P., Echegaray M. C., Navarro B., Moro M. L., Herrero A., Tamargo C., Perez S. J., Antero E., Penacho M. C., Blanco Y., Lucena J., Sisto C. A., Salido E., Dolz F., Granja J. M., Saavedra F., Sanchez-Oro I., Mas-Magro F., Artundo T., Fernandez A., Vaquer J. V., Aso K., Palacios A., Morante J. L., Seller T., Vendrell J. M., Masana, L., Lagares, M., Pinto, X., Reinares, L., Zuniga, M., Descamps, O., Bosi, E., Allaert, F. A., Chapman, J., Bruckert, E., Hernandez, T., Martin, C., Gomes, H., Perez, P. J., Gil, E. M., Moro, A., Jorda, M. D., Lopez, J. L., Alba, M., Bilbao, I., Alustiza, M. R., Aliaga, M., Munoz, J. G., Terol, A. M., Gomez, P., Marcos, M. A., Gonzalez, M., Rodriguez, M. J., Lopez, M. V., Romero, M. A., Puyo, N., Egido, J. F., Monreal, I., Ramirez, A., Madariaga, M. A., De Miguel, M. C., Lorda, A., Munoz, G., Moreno, I. M., Martinez, A., Sanchez, A., Espino, A., Gonzale, z. F. J., Pracht, C., Ocana, C., Pena, M. A., Domingo, C., Gilaberte, M. T., Garcia, C., Diez, J. A., Fornes, F. V., Gutierrez, M. D., Macarra, E., Bugella, J. I., De, l. J. M., Bravo, A., Becerra, M. J., Carbonell, C., De Miguel, M., Perez, A., Martin, A., Romero, J., Gonzalez, P., Iglesias, A., Lopez, B., Villalonga, G., Carvajal, P., Marin, C., Cardona, F., Gonzalez, A., Fernandez, G., Gomez, D., Sanchez, C. L., Viveros, D., De Lucas, M. G., Marin, J. M., Osorno, J., Pumares, C., Gimenez, R., Latorre, J., Barreiro, M. C., Villanueva, J. R., Lopez, J. A., Balaguer, I., Baron, J., Espuga, M., Firas, R., Trias, F., Moran, A., Velasco, V., Vazquez, F., Hernando, A., Manzanares, A., Abad, J. L., Peraferrer, M., Obarrio, A., Alonso, M. L., Gomez, L., Roca, J., Ayus, B. E., Urban, F., Gonzalez, E., Masegosa, C., Barrilero, E., Jimenez, M. C., Carratala, M. M., Petitbo, D., Ferrandiz, J., Mialdea, M. J., Montoro, J., Muncharaz, M. E., Shehchar, A., De Paula, L., Cano, A., Sanchez, L., Perez, J., Alarcon, C., Martinez, J. F., Garrido, T., Martinez, F., Gomariz, I., Caparros, M., Kseibi, T., Palomo, L., Jimenez, T., Luque, I., Villar, P., Gonzalez, J. J., Aparicio, J., Jimenez, O., Munoz, J. J., Baez, F., Marcos, M. P., Gonzalez, T., Estevez, J. A., Garcia, J., Ajuria-Gogeasko, S., Cabrera, M., Manzano, J. M., Segura, G., Abat, X., Yanovsky, N., Borrachero, J. M., Fortuny, M., Martinez, M. D., Gutierrez, A. R., Najem, N., Romero, M. C., Martin, S., Valverde, R. J., Molina, C., Martinez, B., Izquierdo, L., Vazquez, I., Martinez, M. T., Mateos, A., Quiles, F., Aranda, F. J., Iborra, R., Valero, A. B., Fornes, M. T., Quinza, V., Colado, F., Arribas, B., Martinez, J. E. L., Garces, M. P., Valero, J. M., Frigola, J. L., Rubio, J. M., Gongora, A., Triana, J., Gomez, C., Garcia, M. L., Diez, C., Pombo, G., Gutierrez, M. C., Nazara, C. A., De Oca, M. A., Maquieira, N., Pilo, A., Buenadicha, J. L., Duran, F., Pena, J. E., Navarro, S., Serrano, F. J., Sanchez, S., Mesa, S., Salazar, J. A., De La Escosura, A., Perez, F., Solera, J., Tarraga, P., Ramos, L., Gutierrez, J. A., Caldelas, S., Albinana, F., Lopez, J. F., Florian, J., Rocha, E., Rodriguez, J., Mellado, M. L., Calvillo, M. R., Cruz, T., Capitan, M., Diaz, J., Tome, J., Prieto, A., Tome, V., Caro, M., Montero, A., Ontoria, M., Garcia, D. L., Gil, F., De Zarate, V., Casaponsa, J., Matamala, J., Salvande, A., Trueba, M. A., Cidra, J. L., Garcia, A., Toro, A., Berna, J. R., Zornoza, B., Prieto, M. T., Garcia, L., Lopez, C., Garcia, P., Echegaray, M. C., Navarro, B., Moro, M. L., Herrero, A., Tamargo, C., Perez, S. J., Antero, E., Penacho, M. C., Blanco, Y., Lucena, J., Sisto, C. A., Salido, E., Dolz, F., Granja, J. M., Saavedra, F., Sanchez-Oro, I., Mas-Magro, F., Artundo, T., Fernandez, A., Vaquer, J. V., Aso, K., Palacios, A., Morante, J. L., Seller, T., and Vendrell, J. M.

Subjects
Hypercholesterolemia, Phytosterol, Fermented milk, Lifestyle, Diet
Abstract

Introduction: RECIPE study was designed to assess the impact of dietary supplementation with fermented milk enriched with plant sterols (FMPS) on the nutritional behavior, lifestyle and the joint therapeutic responsibility of hypercholesterolemic patients. Methods: Observational, prospective, multicenter, international study, was conducted to assess dietary habits and other lifestyle components in hypercholesterolemic patients in whom the general practitioner indicated FMPS supplementation. Nutritional, lifestyle and clinical data were collected at the initial visit and after a 4 months follow-up. The biochemical and anthropometric data were retrieved from medical records obtained at baseline and 4 months. Results: We report the results of Spain. Two hundred and one physicians who provided valid data of 1044 patients participated. The addition of FMPS was associated with improved overall nutritional index, being adequate initially in 28.2% of patients, and increasing up to 75.2% at the end of the study (P< 001). This nutritional change was associated with an improvement in the lipid profile and anthropometric data. Patients more adherent to therapy generally achieved a better result in all parameters compared to non-compliant ones. Conclusions: The addition of FMPS to a diet designed to reduce the LDL enhances the patient's attitude regarding changes in lifestyle, leading to better overall control of dyslipidemia and anthropometric improvement. © 2012 Elsevier España, S.L. and SEA.

Published
2012

25. Survey explores active tectonics in northeastern Caribbean

Author

Carbó;, A., primary, Córdoba, D., additional, Muñ Martín, A., additional, Granja, J. L., additional, Dávila, J. Martín, additional, Pazos, A., additional, Catalán, M., additional, Gómez, M., additional, Brink, U. ten, additional, Von Hilldebrandt, C., additional, and Payero, J., additional

Published
2005
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28. Design and validation of a minimalist, open-source system for measuring elastic modulus evolution in cementitious materials.

Author

Rocha Ribeiro, R., Russo, T., Araghi, A., Granja, J. L., Azenha, M., and Lameiras, R.

Abstract

The elastic modulus evolution of cementitious materials since early ages can be experimentally measured with the EMM-ARM (Elastic Modulus Measurement through Ambient Response Method) test. This methodology has been extensively validated, but its original implementation relied on costly proprietary platforms. A minimalist, open-source test system may provide a benchmark that sets minimum requirements and performance to enable the development of tailor-made systems. This work aimed to develop, characterise, and validate such system, composed of data-acquisition hardware and post-processing software. Characterisation results showed the system had a spectral noise floor of 2.1 × 10−8 g2/Hz, an RMS noise of 0.003 g, a sampling frequency variability of ± 0.006%, and an average power consumption of 41.53 mAh. Compared to an original EMM-ARM system, validation results indicated the proposed system had an absolute error lower than 0.3% from 1 day of testing onwards, with a similar coefficient of variation of 1.2%. [ABSTRACT FROM AUTHOR]

Published
2025
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31. The Smallest α,γ-Peptide Nanotubulet Segments:  Cyclic α,γ-Tetrapeptide Dimers

Author

Amorin, M., Brea, R. J., Castedo, L., and Granja, J. R.

Abstract

Cyclic tetrapeptides in which α-amino acids alternate with cis-3-aminocycloalkanecarboxylic acids dimerize by forming hydrogen bonds between their α-faces but not between their γ-faces, establishing the minimal structural requirements for the novel α,γ-peptide hybrids SPN.

Published
2005

32. Tandem RCM of Dienynes for the Construction of Taxol-Type Carbocyclic Systems

Author

Garcia-Fandino, R., Codesido, E. M., Sobarzo-Sanchez, E., Castedo, L., and Granja, J. R.

Abstract

Tandem ring-closing metathesis of hydrindanone dienynes allows access to taxosteroids, a new class of compounds that combine the [5.3.1] carbocyclic system of taxanes with rings C and D of the steroid skeleton.

Published
2004

33. Toward an Analogue of the Transition State of PreD<INF>3</INF>−D<INF>3</INF> Isomerization: Stereoselective Synthesis of Linearly Fused 6-8-6 Carbocyclic Systems<SUP>1</SUP>

Author

Codesido, E. M., Rodriguez, J. R., Castedo, L., and Granja, J. R.

Abstract

A stereoselective synthesis of 6-8-6 fused carbocyclic systems based on enol alkylation, ketone allylation, RCM, and Heck cyclization was developed to obtain compounds with a carbon framework that mimics the putative transition structure of the isomerization of previtamin D3 to vitamin D3.

Published
2002
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35. Access to [6.4.0]Carbocyclic Systems by Tandem Metathesis of Dienynes. A Step toward the Synthesis of a PreD<INF>3</INF>−D<INF>3</INF> Transition State Analogue

Author

Codesido, E. M., Castedo, L., and Granja, J. R.

Abstract

A new approach to the synthesis of linearly fused 6−8−6 tricarbocyclic systems, tandem ring-closing metathesis of dienynes, allows access to compounds with a carbon framework analogous to the proposed transition state of the isomerization of previtamin D3 to vitamin D3.

Published
2001

36. Bond on NSM CFRP systems: Recent contributions of uminho on durability, quality control and design

Author

Sena-Cruz, J., Fernandes, P., Mário Coelho, Silva, P., Granja, J., Benedetti, A., Azenha, M., Neves, L., and Universidade do Minho

Subjects
Design, Engenharia e Tecnologia::Engenharia Civil, NSM, CFRP, Bond, Durability, Concrete
Abstract

In the last years, significant research in the context of bond of near-surface mounted (NSM) fibre reinforced polymer (FRP) systems in concrete has been conducted at the Department of Civil Engineering of the University of Minho. This paper presents a brief summary of the major results obtained in that research, namely in terms of durability, quality control and design topics. Accelerated ageing tests on NSM FRP bond specimens were conducted to simulate different environmental conditions. A new method was developed and applied to investigate the evolution of the adhesive stiffness and the bond behaviour of NSM systems for different curing conditions used for quality control of FRP installations. Regarding the bond design, two existing guidelines’ formulas were adapted to the partial safety factors framework., This work was supported by FEDER funds through the Operational Program for Competitiveness Factors – COMPETE and National Funds through FCT (Portuguese Foundation for Science and Technology) under the projects CutInDur FCOMP-01-0124-FEDER-014811 (FCT PTDC/ECM/112396/2009), FRPreDur FCOMP-01- 0124-FEDER-028865 (FCT PTDC/ECM-EST/2424/2012), FRPLongDur POCI-01-0145-FEDER-016900 (FCT PTDC/ECM-EST/1282/2014) and partly financed by the project POCI-01-0145-FEDER-007633. The following individual grants are also acknowledged: SFRH/BD/80338/2011 (P. Fernandes), SFRH/BD/87443/2012 (M. Coelho), SFRH/BD/89768/2012 (P. Silva) and SFRH/BD/80682/2011 (J. Granja).

37. Communication tools used by distributed teams in a BIM learning project

Author

Rzhvskyi, A., Bil, E. A., GABRIELA WITECK, Aquere, A. L., Lima, R. M., Granja, J., Azenha, M., and Universidade do Minho

Subjects
Agile Project Management, Communications tools, Distributed teams, Lean project management
Abstract

The constant changes in the world market demand flexible and fluid organizational structures, such as rotating and engaging human effort, to provide high performance. Therefore, organizations make use of distributed multicultural teams, meetings, and online lead projects. However, these social categorization processes can become a disadvantage if trigger potential conflicts during task performance. Distributed teams can also be difficult to manage, and their members can face extra adversities in communication. Architecture, Engineering and Construction Industry (AEC), is a context where the use of distributed teams is growing significantly, particularly through the enabling features of Building Information Modelling (BIM) methodologies. This paper was aimed at the diagnosis of communication behaviour in distributed teams in the context of a PBL methodology that requested students to work in distributed teams on two distinct locations. For that, the authors managed a workshop on Lean Project Management and Collaborative Tools in the European Master in Building Information Modelling (BIM A+) using a Lego for Scrum activity, adapted to a team of students distributed in Portugal and Slovenia. After that, nine distributed teams of students had to design exposition pavilions in BIM platform and using collaborative tools. At the end, each team had to present the project for the entire body of students and faculty, located in Guimaraes (Portugal) and Ljubljana (Slovenia)., (undefined)

38. Monitoring elastic properties of concrete since very early age by means of cyclic loadings, ultrasonic measurements, natural resonant frequency of composite beam (EMM-ARM) and with smart aggregates

Author

Boulay, C., Staquet, S., Miguel Azenha, Deraemaeker, A., Crespini, M., Carette, J., Granja, J., Delsaute, B., Dumoulin, C., Karaiskos, G., and Mechanics of Materials and Constructions

Subjects
early-age concrete, concrete cracking, Essais non destructifs, round robin experimental test
Abstract

Early age cracking of structures often leads to aesthetic problems and service life reduction. Among the parameters involved in the stress build-up that causes this cracking process, the stiffness evolution is of major importance for models and numerical computations. This paper reports the use of six different techniques aimed for stiffness evolution assessment, applied on the same concrete mix, in a round robin experimental test within three laboratories. The observations are compared after having expressed the results at the same maturity. Some of the reported techniques provide original means for Young's modulus monitoring of concrete at early age both for industrial and research applications. Two sets of results emerge. Ultrasonic measurements provide values of Young's modulus much higher than the values provided by the static or quasi static tests at the time of the concrete setting. This difference decreases as the concrete hardens.

39. Combined bender elements and accelerometers system: Measurement and interpretation

Author

Pereira, C., Granja, J., Gomes Correia, A., Ferreira, C., Miguel Azenha, Nazarian, S., and Universidade do Minho

Subjects
Bender Elements, Seismic waves, Engenharia e Tecnologia::Engenharia Civil, Measurements, Accelerometers, Stiffness
Abstract

Useful to define the stiffness of geomaterials at very small strains, the assessment of seismic wave velocities in the laboratory is currently a worldwide common practice. The combined use of piezoelectric transducers such as bender elements and accelerometers, already proved to be a simple but powerful laboratory tool for seismic wave measurements, helping decrease some subjectivity inherent to BE when used individually. Additionally, the simultaneous use of time and frequency domain signal analysis techniques is considered a useful alternative to reduce error in seismic wave measurements. This paper presents a combined bender elements and accelerometers test setup implemented on a stress-path triaxial chamber as well as a seismic-wave acquisition software that allows simultaneously time and frequency domain analyses on soil samples. Finally, an application study is presented for a monogranular sand tested in triaxial compression at different isotropic stress levels., This work was developed under the financial support provided by FCT (Portuguese Foundation for Science and Technology), including in the form of the research project WaveSoil – PTDC/ECM122751/2010 from FCOMOP – 01 – 0124 – FEDER - 020365 project., info:eu-repo/semantics/publishedVersion

48. ChemInform Abstract: Design and Synthesis of 1α,25‐Dihydroxyvitamin D3Analogues with Fixed Torsion Angle C(16‐17‐20‐22).

Author

MARTINEZ‐PEREZ, J. A., SARANDESES, L., GRANJA, J., PALENZUELA, J. A., and MOURINO, A.

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Published
1998
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50. Rumo à definição de Product Data Templates nacionais para aplicação generalizada em contexto BIM: Esforços da CT197

Author

Mohamad El Sibaii, José Granja, Renan Rocha Ribeiro, Pedro Meda, Ricardo Resende, João dos Santos, Pedro Lucas Martins, António Aguiar Costa, João Poças Martins, Miguel Azenha, Faculdade de Engenharia, Universidade do Minho, and Azenha, M., Lino, J. C., Granja, J., Figueiredo, B., e Martins, J. P.

Subjects
'Building Information Modelling', 'Product Data Templates', Product Data Templates, Interoperabilidade, Engenharia e Tecnologia::Outras Engenharias e Tecnologias, Building Information Modelling, Normalização, Indústria AECO
Abstract

A normalização é um dos elementos mais importantes para a implementação dos processos BIM. De facto, trata-se de fator primordial para colaboração eficaz entre os intervenientes da indústria AECO. Um dos importantes vértices a ter em conta na normalização diz respeito à definição da informação alfanumérica relevante, bem como a sua respetiva nomenclatura. Este tipo de definições corresponde a estruturas normalizadas de dados para produtos de construção, designados na língua inglesa por: 'Product Data Template' (PDT). Apesar de já existirem algumas iniciativas a nível internacional para definição de PDTs, trata-se de um processo ainda em fase de maturação a nível mundial, mas que reconhecidamente carece de definições específicas ao contexto de cada país (conforme determinado na ISO 23386:2020, por exemplo). No contexto da CT197 (comissão de normalização nacional BIM, sob alçada do Instituto Português da Qualidade) e de projetos de investigação em curso (p.ex. SECClasS, REV@Construction, e GrowingCircle), a equipa do presente artigo está a encetar esforços comuns rumo ao estabelecimento de PDT’s a nível nacional. O presente artigo descreve esses esforços, com enfoque particular na perspetiva de mobilização da indústria. Os trabalhos a encetar envolvem a auscultação direta a vários intervenientes na cadeia de valor para formulação/validação de PDTs, mas também terão em conta várias outras fontes/fatores como os requisitos de interoperabilidade 'Industry Foundation Classes' (IFC) e outras iniciativas de normalização e regulamentação a nível nacional e europeu., Este trabalho foi parcialmente financiado pelo Projeto 19_Call#2_SECClasS – Sustainability Enhanced Construction Classification System, financiado pelo EEA Grants Portugal e pelo projeto mobilizador REV@Construction; parcialmente financiado pela FCT/MCTES através de fundos nacionais (PIDDAC) no âmbito dos projetos UIDB/04466/2020 e UIDP/04466/2020 da Unidade de I&D ISTAR-IUL – Centro de Investigação em Ciências da Informação, Tecnologias e Arquitetura; no âmbito do projeto UIDB / 04029/2020 da unidade de I&D Instituto para a Sustentabilidade e Inovação em Engenharia Estrutural (ISISE); parcialmente financiado por: Financiamento Base - UIDB/04708/2020 da Unidade de Investigação CONSTRUCT - Instituto de I&D em Estruturas e Construções – financiada por fundos nacionais através da FCT/MCTES (PIDDAC). e apoiado pelo Comité Técnico de Normalização CT197.

Published
2022

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