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1. Incidence, microbiological and immunological characteristics of ventilator-associated pneumonia assessed by bronchoalveolar lavage and endotracheal aspirate in a prospective cohort of COVID-19 patients: CoV-AP study

Author

Mangioni, Davide, Panigada, Mauro, Palomba, Emanuele, Bobbio, Chiara, Chatenoud, Liliane, Alagna, Laura, Fumagalli, Jacopo, Gori, Andrea, Grancini, Anna, Guzzardella, Amedeo, Lombardi, Andrea, Matinato, Caterina, Meli, Andrea, Muscatello, Antonio, Porretti, Laura, Tomasello, Mara, Trombetta, Elena, Valenti, Luca, Bandera, Alessandra, and Grasselli, Giacomo

Published
2023
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2. European candidaemia is characterised by notable differential epidemiology and susceptibility pattern: Results from the ECMM Candida III study

Author

Arendrup, Maiken Cavling, Arikan-Akdagli, Sevtap, Jørgensen, Karin Meinike, Barac, Aleksandra, Steinmann, Jörg, Toscano, Cristina, Arsenijevic, Valentina Arsic, Sartor, Assunta, Lass-Flörl, Cornelia, Hamprecht, Axel, Matos, Tadeja, Rogers, Benedict R.S., Quiles, Inmaculada, Buil, Jochem, Özenci, Volkan, Krause, Robert, Bassetti, Matteo, Loughlin, Laura, Denis, Blandine, Grancini, Anna, White, P. Lewis, Lagrou, Katrien, Willinger, Birgit, Rautemaa-Richardson, Riina, Hamal, Petr, Ener, Beyza, Unalan-Altintop, Tugce, Evren, Ebru, Hilmioglu-Polat, Suleyha, Oz, Yasemin, Ozyurt, Ozlem Koyuncu, Aydin, Faruk, Růžička, Filip, Meijer, Eelco F.J., Gangneux, Jean Pierre, Lockhart, Deborah E.A., Khanna, Nina, Logan, Clare, Scharmann, Ulrike, Desoubeaux, Guillaume, Roilides, Emmanuel, Talento, Alida Fe, van Dijk, Karin, Koehler, Philipp, Salmanton-García, Jon, Cornely, Oliver A., and Hoenigl, Martin

Published
2023
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8. European candidaemia is characterised by notable differential epidemiology and susceptibility pattern:Results from the ECMM Candida III study

Author

Arendrup, Maiken Cavling, Arikan-Akdagli, Sevtap, Jørgensen, Karin Meinike, Barac, Aleksandra, Steinmann, Jörg, Toscano, Cristina, Arsenijevic, Valentina Arsic, Sartor, Assunta, Lass-Flörl, Cornelia, Hamprecht, Axel, Matos, Tadeja, Rogers, Benedict R.S., Quiles, Inmaculada, Buil, Jochem, Özenci, Volkan, Krause, Robert, Bassetti, Matteo, Loughlin, Laura, Denis, Blandine, Grancini, Anna, White, P. Lewis, Lagrou, Katrien, Willinger, Birgit, Rautemaa-Richardson, Riina, Hamal, Petr, Ener, Beyza, Unalan-Altintop, Tugce, Evren, Ebru, Hilmioglu-Polat, Suleyha, Oz, Yasemin, Ozyurt, Ozlem Koyuncu, Aydin, Faruk, Růžička, Filip, Meijer, Eelco F.J., Gangneux, Jean Pierre, Lockhart, Deborah E.A., Khanna, Nina, Logan, Clare, Scharmann, Ulrike, Desoubeaux, Guillaume, Roilides, Emmanuel, Talento, Alida Fe, van Dijk, Karin, Koehler, Philipp, Salmanton-García, Jon, Cornely, Oliver A., Hoenigl, Martin, Arendrup, Maiken Cavling, Arikan-Akdagli, Sevtap, Jørgensen, Karin Meinike, Barac, Aleksandra, Steinmann, Jörg, Toscano, Cristina, Arsenijevic, Valentina Arsic, Sartor, Assunta, Lass-Flörl, Cornelia, Hamprecht, Axel, Matos, Tadeja, Rogers, Benedict R.S., Quiles, Inmaculada, Buil, Jochem, Özenci, Volkan, Krause, Robert, Bassetti, Matteo, Loughlin, Laura, Denis, Blandine, Grancini, Anna, White, P. Lewis, Lagrou, Katrien, Willinger, Birgit, Rautemaa-Richardson, Riina, Hamal, Petr, Ener, Beyza, Unalan-Altintop, Tugce, Evren, Ebru, Hilmioglu-Polat, Suleyha, Oz, Yasemin, Ozyurt, Ozlem Koyuncu, Aydin, Faruk, Růžička, Filip, Meijer, Eelco F.J., Gangneux, Jean Pierre, Lockhart, Deborah E.A., Khanna, Nina, Logan, Clare, Scharmann, Ulrike, Desoubeaux, Guillaume, Roilides, Emmanuel, Talento, Alida Fe, van Dijk, Karin, Koehler, Philipp, Salmanton-García, Jon, Cornely, Oliver A., and Hoenigl, Martin

Abstract

The objectives of this study were to assess Candida spp. distribution and antifungal resistance of candidaemia across Europe. Isolates were collected as part of the third ECMM Candida European multicentre observational study, conducted from 01 to 07-07-2018 to 31-03-2022. Each centre (maximum number/country determined by population size) included ∼10 consecutive cases. Isolates were referred to central laboratories and identified by morphology and MALDI-TOF, supplemented by ITS-sequencing when needed. EUCAST MICs were determined for five antifungals. fks sequencing was performed for echinocandin resistant isolates. The 399 isolates from 41 centres in 17 countries included C. albicans (47.1%), C. glabrata (22.3%), C. parapsilosis (15.0%), C. tropicalis (6.3%), C. dubliniensis and C. krusei (2.3% each) and other species (4.8%). Austria had the highest C. albicans proportion (77%), Czech Republic, France and UK the highest C. glabrata proportions (25–33%) while Italy and Turkey had the highest C. parapsilosis proportions (24–26%). All isolates were amphotericin B susceptible. Fluconazole resistance was found in 4% C. tropicalis, 12% C. glabrata (from six countries across Europe), 17% C. parapsilosis (from Greece, Italy, and Turkey) and 20% other Candida spp. Four isolates were anidulafungin and micafungin resistant/non-wild-type and five resistant to micafungin only. Three/3 and 2/5 of these were sequenced and harboured fks-alterations including a novel L657W in C. parapsilosis. The epidemiology varied among centres and countries. Acquired echinocandin resistance was rare but included differential susceptibility to anidulafungin and micafungin, and resistant C. parapsilosis. Fluconazole and voriconazole cross-resistance was common in C. glabrata and C. parapsilosis but with different geographical prevalence., The objectives of this study were to assess Candida spp. distribution and antifungal resistance of candidaemia across Europe. Isolates were collected as part of the third ECMM Candida European multicentre observational study, conducted from 01 to 07-07-2018 to 31-03-2022. Each centre (maximum number/country determined by population size) included ∼10 consecutive cases. Isolates were referred to central laboratories and identified by morphology and MALDI-TOF, supplemented by ITS-sequencing when needed. EUCAST MICs were determined for five antifungals. fks sequencing was performed for echinocandin resistant isolates. The 399 isolates from 41 centres in 17 countries included C. albicans (47.1%), C. glabrata (22.3%), C. parapsilosis (15.0%), C. tropicalis (6.3%), C. dubliniensis and C. krusei (2.3% each) and other species (4.8%). Austria had the highest C. albicans proportion (77%), Czech Republic, France and UK the highest C. glabrata proportions (25–33%) while Italy and Turkey had the highest C. parapsilosis proportions (24–26%). All isolates were amphotericin B susceptible. Fluconazole resistance was found in 4% C. tropicalis, 12% C. glabrata (from six countries across Europe), 17% C. parapsilosis (from Greece, Italy, and Turkey) and 20% other Candida spp. Four isolates were anidulafungin and micafungin resistant/non-wild-type and five resistant to micafungin only. Three/3 and 2/5 of these were sequenced and harboured fks-alterations including a novel L657W in C. parapsilosis. The epidemiology varied among centres and countries. Acquired echinocandin resistance was rare but included differential susceptibility to anidulafungin and micafungin, and resistant C. parapsilosis. Fluconazole and voriconazole cross-resistance was common in C. glabrata and C. parapsilosis but with different geographical prevalence.

Published
2023

9. Yeast Bloodstream Infections in the COVID-19 Patient: A Multicenter Italian Study (FiCoV Study)

Author

Prigitano, Anna, Blasi, Elisabetta, Calabrò, Maria, Cavanna, Caterina, Cornetta, Maria, Farina, Claudio, Grancini, Anna, Innocenti, Patrizia, Cascio, Giuliana Lo, Nicola, Lucia, Trovato, Laura, Cogliati, Massimo, Esposto, Maria Carmela, Tortorano, Anna Maria, Romanò, Luisa, and Group, on behalf of the FiCoV Study Group on behalf of the FiCoV Study

Subjects
Microbiology (medical), invasive fungal infections, fungemia, candidemia, COVID-19, Plant Science, antifungal resistance, Ecology, Evolution, Behavior and Systematics
Abstract

Fungemia is a co-infection contributing to the worsening of the critically ill COVID-19 patient. The multicenter Italian observational study FiCoV aims to estimate the frequency of yeast bloodstream infections (BSIs), to describe the factors associated with yeast BSIs in COVID-19 patients hospitalized in 10 hospitals, and to analyze the antifungal susceptibility profiles of the yeasts isolated from blood cultures. The study included all hospitalized adult COVID-19 patients with a yeast BSI; anonymous data was collected from each patient and data about antifungal susceptibility was collected. Yeast BSI occurred in 1.06% of patients, from 0.14% to 3.39% among the 10 participating centers. Patients were mainly admitted to intensive or sub-intensive care units (68.6%), over 60 years of age (73%), with a mean and median time from the hospitalization to fungemia of 29 and 22 days, respectively. Regarding risk factors for fungemia, most patients received corticosteroid therapy during hospitalization (61.8%) and had a comorbidity (25.3% diabetes, 11.5% chronic respiratory disorder, 9.5% cancer, 6% haematological malignancies, 1.4% organ transplantation). Antifungal therapy was administered to 75.6% of patients, mostly echinocandins (64.5%). The fatality rate observed in COVID-19 patients with yeast BSI was significantly higher than that of COVID-19 patients without yeast BSI (45.5% versus 30.5%). Candida parapsilosis (49.8%) and C. albicans (35.2%) were the most fungal species isolated; 72% of C. parapsilosis strains were fluconazole-resistant (range 0–93.2% among the centers). The FiCoV study highlights a high prevalence of Candida BSIs in critically ill COVID-19 patients, especially hospitalized in an intensive care unit, a high fatality rate associated with the fungal co-infection, and the worrying spread of azole-resistant C. parapsilosis.

Published
2023
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12. Pneumocystis jirovecii pneumonia in HIV-negative patients, a frequently overlooked problem. A case series from a large Italian center

Author

Bozzi, Giorgio, primary, Saltini, Paola, additional, Matera, Malvina, additional, Morena, Valentina, additional, Castelli, Valeria, additional, Peri, Anna Maria, additional, Taramasso, Lucia, additional, Ungaro, Riccardo, additional, Lombardi, Andrea, additional, Muscatello, Antonio, additional, Bono, Patrizia, additional, Grancini, Anna, additional, Maraschini, Anna, additional, Matinato, Caterina, additional, Gori, Andrea, additional, and Bandera, Alessandra, additional

Published
2022
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13. Mucormycosis in CAPA, a Possible Fungal Super-Infection

Author

Saltini, Paola, primary, Palomba, Emanuele, additional, Castelli, Valeria, additional, Fava, Marco, additional, Alagna, Laura, additional, Biscarini, Simona, additional, Mantero, Marco, additional, Blasi, Francesco, additional, Grancini, Anna, additional, Bandera, Alessandra, additional, Gori, Andrea, additional, Muscatello, Antonio, additional, and Lombardi, Andrea, additional

Published
2021
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16. Invasive fungal infections in the intensive care unit: a multicentre, prospective, observational study in Italy (2006–2008)

Author

Tortorano, Anna Maria, Dho, Giovanna, Prigitano, Anna, Breda, Giuseppe, Grancini, Anna, Emmi, Vincenzo, Cavanna, Caterina, Marino, Giovanni, Morero, Silvia, Ossi, Cristina, Delvecchio, Giacomo, Passera, Marco, Cusumano, Vitaliano, David, Antonio, Bonaccorso, Giuseppina, Corona, Alberto, Favaro, Myriam, Vismara, Chiara, Garau, Maria Graziella, Falchi, Susanna, and Tejada, Milvana R.

Published
2012
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17. Azole resistance in Aspergillus isolates by different types of patients and correlation with environment ‐ An Italian prospective multicentre study (ARiA study)

Author

Prigitano, Anna, primary, Esposto, Maria C., additional, Grancini, Anna, additional, Biffi, Arianna, additional, Innocenti, Patrizia, additional, Cavanna, Caterina, additional, Lallitto, Fabiola, additional, Mollaschi, Eva Maria Giada, additional, Bandettini, Roberto, additional, Oltolini, Chiara, additional, Passera, Marco, additional, De Lorenzis, Gabriella, additional, Sargolzaei, Maryam, additional, Crespan, Manna, additional, Cogliati, Massimo, additional, Tortorano, Anna Maria, additional, and Romanò, Luisa, additional

Published
2021
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19. Scedosporium apiospermum infection mimicking erythema nodosum: the importance of culture samples in immunocompromised patients with panniculitis.

Author

Bortoluzzi, Paolo, Romagnuolo, Maurizio, Boggio, Francesca, Grancini, Anna, Aromolo, Italo Francesco, and Marzano, Angelo V

Subjects
ERYTHEMA nodosum, ADIPOSE tissue diseases, IMMUNOCOMPROMISED patients, INFECTION
Abstract

A full-body CT scan revealed multiple pulmonary nodules and paravertebral involvement, leading to the diagnosis of systemic I S. apiospermum i infection. Infective panniculitis represents a small percentage of the broad spectrum of panniculitis, and the subgroup of fungal panniculitis is even more rare.[1] Fungal panniculitis may be divided into two groups depending on the origin of fungal invasion: (1) subcutaneous mycoses where the infective agent is introduced into the panniculus by direct inoculation from the skin and (2) disseminate fungal infection where the invasion of the panniculus by the fungus originates from vascular or lymphatic vessels. [Extracted from the article]

Published
2023
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20. Azole-Resistance in Aspergillus terreus and Related Species: An Emerging Problem or a Rare Phenomenon? (vol 9, 516, 2018)

Author

Zoran, Tamara, Sartori, Bettina, Sappl, Laura, Aigner, Maria, Sanchez-Reus, Ferran, Rezusta, Antonio, Chowdhary, Anuradha, Taj-Aldeen, Saad J., Arendrup, Maiken C., Oliveri, Salvatore, Kontoyiannis, Dimitrios P., Alastruey-Izquierdo, Ana, Lagrou, Katrien, Lo Cascio, Giuliana, Meis, Jacques F., Buzina, Walter, Farina, Claudio, Drogari-Apiranthitou, Miranda, Grancini, Anna, Tortorano, Anna M., Willinger, Birgit, Hamprecht, Axel, Johnson, Elizabeth, Klingspor, Lena, Arsic-Arsenijevic, Valentina, Cornely, Oliver A., Meletiadis, Joseph, Prammer, Wolfgang, Tullio, Vivian, Vehreschild, Joerg-Janne, Trovato, Laura, Lewis, Russell E., Segal, Esther, Rath, Peter-Michael, Hamal, Petr, Rodriguez-Iglesias, Manuel, Roilides, Emmanuel, Arikan-Akdagli, Sevtap, Chakrabarti, Arunaloke, Colombo, Arnaldo L., Fernandez, Mariana S., Teresa Martin-Gomez, M., Badali, Hamid, Petrikkos, Georgios, Klimko, Nikolai, Heimann, Sebastian M., Uzun, Omrum, Roudbary, Maryam, de la Fuente, Sonia, Houbraken, Jos, Risslegger, Brigitte, Sabino, Raquel, Lass-Florl, Cornelia, Lackner, Michaela, Westerdijk Fungal Biodiversity Institute - Food and Indoor Mycology, and Westerdijk Fungal Biodiversity Institute

Subjects
cryptic species, Cyp51A alterations, azoles, susceptibility profiles, Aspergillus section Terrei
Published
2019

21. Outbreak of Saprochaete clavata Sepsis in Hematology Patients: Combined Use of MALDI-TOF and Sequencing Strategy to Identify and Correlate the Episodes

Author

Lo Cascio, Giuliana, primary, Vincenzi, Marcello, additional, Soldani, Fabio, additional, De Carolis, Elena, additional, Maccacaro, Laura, additional, Sorrentino, Annarita, additional, Nadali, Gianpaolo, additional, Cesaro, Simone, additional, Sommavilla, Michele, additional, Niero, Valentina, additional, Naso, Laura, additional, Grancini, Anna, additional, Azzini, Anna Maria, additional, Sanguinetti, Maurizio, additional, Tacconelli, E., additional, and Cornaglia, Giuseppe, additional

Published
2020
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22. Epidemiology and treatment approaches in management of invasive fungal infections in hematological malignancies: Results from a single-centre study

Author

Fracchiolla, Nicola Stefano, primary, Sciumè, Mariarita, additional, Orofino, Nicola, additional, Guidotti, Francesca, additional, Grancini, Anna, additional, Cavalca, Fabrizio, additional, Freyrie, Alessandra, additional, Goldaniga, Maria Cecilia, additional, Consonni, Dario, additional, Mattiello, Veronica, additional, Pettine, Loredana, additional, and Cortelezzi, Agostino, additional

Published
2019
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24. Corrigendum: Azole-Resistance in Aspergillus terreus and Related Species: An Emerging Problem or a Rare Phenomenon?

Author

Zoran, Tamara, primary, Sartori, Bettina, additional, Sappl, Laura, additional, Aigner, Maria, additional, Sánchez-Reus, Ferran, additional, Rezusta, Antonio, additional, Chowdhary, Anuradha, additional, Taj-Aldeen, Saad J., additional, Arendrup, Maiken C., additional, Oliveri, Salvatore, additional, Kontoyiannis, Dimitrios P., additional, Alastruey-Izquierdo, Ana, additional, Lagrou, Katrien, additional, Lo Cascio, Giuliana, additional, Meis, Jacques F., additional, Buzina, Walter, additional, Farina, Claudio, additional, Drogari-Apiranthitou, Miranda, additional, Grancini, Anna, additional, Tortorano, Anna M., additional, Willinger, Birgit, additional, Hamprecht, Axel, additional, Johnson, Elizabeth, additional, Klingspor, Lena, additional, Arsic-Arsenijevic, Valentina, additional, Cornely, Oliver A., additional, Meletiadis, Joseph, additional, Prammer, Wolfgang, additional, Tullio, Vivian, additional, Vehreschild, Jörg-Janne, additional, Trovato, Laura, additional, Lewis, Russell E., additional, Segal, Esther, additional, Rath, Peter-Michael, additional, Hamal, Petr, additional, Rodriguez-Iglesias, Manuel, additional, Roilides, Emmanuel, additional, Arikan-Akdagli, Sevtap, additional, Chakrabarti, Arunaloke, additional, Colombo, Arnaldo L., additional, Fernández, Mariana S., additional, Martin-Gomez, M. Teresa, additional, Badali, Hamid, additional, Petrikkos, Georgios, additional, Klimko, Nikolai, additional, Heimann, Sebastian M., additional, Uzun, Omrum, additional, Roudbary, Maryam, additional, de la Fuente, Sonia, additional, Houbraken, Jos, additional, Risslegger, Brigitte, additional, Sabino, Raquel, additional, Lass-Flörl, Cornelia, additional, and Lackner, Michaela, additional

Published
2019
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26. Azole-Resistance in Aspergillus terreus and Related Species: An Emerging Problem or a Rare Phenomenon?

Author

Zoran, Tamara, primary, Sartori, Bettina, additional, Sappl, Laura, additional, Aigner, Maria, additional, Sánchez-Reus, Ferran, additional, Rezusta, Antonio, additional, Chowdhary, Anuradha, additional, Taj-Aldeen, Saad J., additional, Arendrup, Maiken C., additional, Oliveri, Salvatore, additional, Kontoyiannis, Dimitrios P., additional, Alastruey-Izquierdo, Ana, additional, Lagrou, Katrien, additional, Cascio, Giuliana Lo, additional, Meis, Jacques F., additional, Buzina, Walter, additional, Farina, Claudio, additional, Drogari-Apiranthitou, Miranda, additional, Grancini, Anna, additional, Tortorano, Anna M., additional, Willinger, Birgit, additional, Hamprecht, Axel, additional, Johnson, Elizabeth, additional, Klingspor, Lena, additional, Arsic-Arsenijevic, Valentina, additional, Cornely, Oliver A., additional, Meletiadis, Joseph, additional, Prammer, Wolfgang, additional, Tullio, Vivian, additional, Vehreschild, Jörg-Janne, additional, Trovato, Laura, additional, Lewis, Russell E., additional, Segal, Esther, additional, Rath, Peter-Michael, additional, Hamal, Petr, additional, Rodriguez-Iglesias, Manuel, additional, Roilides, Emmanuel, additional, Arikan-Akdagli, Sevtap, additional, Chakrabarti, Arunaloke, additional, Colombo, Arnaldo L., additional, Fernández, Mariana S., additional, Martin-Gomez, M. Teresa, additional, Badali, Hamid, additional, Petrikkos, Georgios, additional, Klimko, Nikolai, additional, Heimann, Sebastian M., additional, Uzun, Omrum, additional, Roudbary, Maryam, additional, de la Fuente, Sonia, additional, Houbraken, Jos, additional, Risslegger, Brigitte, additional, Lass-Flörl, Cornelia, additional, and Lackner, Michaela, additional

Published
2018
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27. Azole-Resistance in Aspergillus terreus and Related Species: An Emerging Problem or a Rare Phenomenon?

Author

Zoran, Tamara, Sartori, Bettina, Sappl, Laura, Aigner, Maria, Sanchez-Reus, Ferran, Rezusta, Antonio, Chowdhary, Anuradha, Taj-Aldeen, Saad J., Arendrup, Maiken C., Oliveri, Salvatore, Kontoyiannis, Dimitrios P., Alastruey-Izquierdo, Ana, Lagrou, Katrien, Lo Cascio, Giuliana, Meis, Jacques F., Buzina, Walter, Farina, Claudio, Drogari-Apiranthitou, Miranda, Grancini, Anna, Tortorano, Anna M., Willinger, Birgit, Hamprecht, Axel, Johnson, Elizabeth, Klingspor, Lena, Arsic-Arsenijevic, Valentina, Cornely, Oliver A., Meletiadis, Joseph, Prammer, Wolfgang, Tullio, Vivian, Vehreschild, Jorg-Janne, Trovato, Laura, Lewis, Russell E., Segal, Esther, Rath, Peter-Michael, Hamal, Petr, Rodriguez-Iglesias, Manuel, Roilides, Emmanuel, Arikan-Akdagli, Sevtap, Chakrabarti, Arunaloke, Colombo, Arnaldo L., Fernandez, Mariana S., Teresa Martin-Gomez, M., Badali, Hamid, Petrikkos, Georgios, Klimko, Nikolai, Heimann, Sebastian M., Uzun, Omrum, Roudbary, Maryam, de la Fuente, Sonia, Houbraken, Jos, Risslegger, Brigitte, Lass-Floerl, Cornelia, Lackner, Michaela, Zoran, Tamara, Sartori, Bettina, Sappl, Laura, Aigner, Maria, Sanchez-Reus, Ferran, Rezusta, Antonio, Chowdhary, Anuradha, Taj-Aldeen, Saad J., Arendrup, Maiken C., Oliveri, Salvatore, Kontoyiannis, Dimitrios P., Alastruey-Izquierdo, Ana, Lagrou, Katrien, Lo Cascio, Giuliana, Meis, Jacques F., Buzina, Walter, Farina, Claudio, Drogari-Apiranthitou, Miranda, Grancini, Anna, Tortorano, Anna M., Willinger, Birgit, Hamprecht, Axel, Johnson, Elizabeth, Klingspor, Lena, Arsic-Arsenijevic, Valentina, Cornely, Oliver A., Meletiadis, Joseph, Prammer, Wolfgang, Tullio, Vivian, Vehreschild, Jorg-Janne, Trovato, Laura, Lewis, Russell E., Segal, Esther, Rath, Peter-Michael, Hamal, Petr, Rodriguez-Iglesias, Manuel, Roilides, Emmanuel, Arikan-Akdagli, Sevtap, Chakrabarti, Arunaloke, Colombo, Arnaldo L., Fernandez, Mariana S., Teresa Martin-Gomez, M., Badali, Hamid, Petrikkos, Georgios, Klimko, Nikolai, Heimann, Sebastian M., Uzun, Omrum, Roudbary, Maryam, de la Fuente, Sonia, Houbraken, Jos, Risslegger, Brigitte, Lass-Floerl, Cornelia, and Lackner, Michaela

Abstract

Objectives: Invasive mold infections associated with Aspergillus species are a significant cause of mortality in immunocompromised patients. The most frequently occurring aetiological pathogens are members of the Aspergillus section Fumigati followed by members of the section Terrei. The frequency of Aspergillus terreus and related (cryptic) species in clinical specimens, as well as the percentage of azole-resistant strains remains to be studied. Methods : A global set (n = 498) of A. terreus and phenotypically related isolates was molecularly identified (beta-tubulin), tested for antifungal susceptibility against posaconazole, voriconazole, and itraconazole, and resistant phenotypes were correlated with point mutations in the cyp51A gene. Results : The majority of isolates was identified as A. terreus (86.8%), followed by A. citrinoterreus (8.4%), A. hortai (2.6%), A. alabamensis (1.6%), A. neoafricanus (0.2%), and A. floccosus (0.2%). One isolate failed to match a known Aspergillus sp., but was found most closely related to A. alabamensis. According to EUCAST clinical breakpoints azole resistance was detected in 5.4% of all tested isolates, 6.2% of A. terreus sensu stricto (s.s.) were posaconazole-resistant. Posaconazole resistance differed geographically and ranged from 0% in the Czech Republic, Greece, and Turkey to 13.7% in Germany. In contrast, azole resistance among cryptic species was rare 2 out of 66 isolates and was observed only in one A. citrinoterreus and one A. alabamensis isolate. The most affected amino acid position of the Cyp51A gene correlating with the posaconazole resistant phenotype was M217, which was found in the variation M217T and M217V. Conclusions : Aspergillus terreus was most prevalent, followed by A. citrinoterreus. Posaconazole was the most potent drug against A. terreus, but 5.4% of A. terreus sensu stricto showed resistance against this azole. In Austria, Germany, and the United Kingdom posaconazole-resistance in all A. terreus isol

Published
2018

28. Azole-resistance in Aspergillus terreus and related species:An emerging problem or a rare Phenomenon?

Author

Zoran, Tamara, Sartori, Bettina, Sappl, Laura, Aigner, Maria, Sánchez-Reus, Ferran, Rezusta, Antonio, Chowdhary, Anuradha, Taj-Aldeen, Saad J., Arendrup, Maiken C., Oliveri, Salvatore, Kontoyiannis, Dimitrios P., Alastruey-Izquierdo, Ana, Lagrou, Katrien, Cascio, Giuliana Lo, Meis, Jacques F., Buzina, Walter, Farina, Claudio, Drogari-Apiranthitou, Miranda, Grancini, Anna, Tortorano, Anna M., Willinger, Birgit, Hamprecht, Axel, Johnson, Elizabeth, Klingspor, Lena, Arsic-Arsenijevic, Valentina, Cornely, Oliver A., Meletiadis, Joseph, Prammer, Wolfgang, Tullio, Vivian, Vehreschild, Jörg Janne, Trovato, Laura, Lewis, Russell E., Segal, Esther, Rath, Peter Michael, Hamal, Petr, Rodriguez-Iglesias, Manuel, Roilides, Emmanuel, Arikan-Akdagli, Sevtap, Chakrabarti, Arunaloke, Colombo, Arnaldo L., Fernández, Mariana S., Martin-Gomez, M. Teresa, Badali, Hamid, Petrikkos, Georgios, Klimko, Nikolai, Heimann, Sebastian M., Uzun, Omrum, Roudbary, Maryam, de la Fuente, Sonia, Houbraken, Jos, Risslegger, Brigitte, Lass-Flörl, Cornelia, Lackner, Michaela, Zoran, Tamara, Sartori, Bettina, Sappl, Laura, Aigner, Maria, Sánchez-Reus, Ferran, Rezusta, Antonio, Chowdhary, Anuradha, Taj-Aldeen, Saad J., Arendrup, Maiken C., Oliveri, Salvatore, Kontoyiannis, Dimitrios P., Alastruey-Izquierdo, Ana, Lagrou, Katrien, Cascio, Giuliana Lo, Meis, Jacques F., Buzina, Walter, Farina, Claudio, Drogari-Apiranthitou, Miranda, Grancini, Anna, Tortorano, Anna M., Willinger, Birgit, Hamprecht, Axel, Johnson, Elizabeth, Klingspor, Lena, Arsic-Arsenijevic, Valentina, Cornely, Oliver A., Meletiadis, Joseph, Prammer, Wolfgang, Tullio, Vivian, Vehreschild, Jörg Janne, Trovato, Laura, Lewis, Russell E., Segal, Esther, Rath, Peter Michael, Hamal, Petr, Rodriguez-Iglesias, Manuel, Roilides, Emmanuel, Arikan-Akdagli, Sevtap, Chakrabarti, Arunaloke, Colombo, Arnaldo L., Fernández, Mariana S., Martin-Gomez, M. Teresa, Badali, Hamid, Petrikkos, Georgios, Klimko, Nikolai, Heimann, Sebastian M., Uzun, Omrum, Roudbary, Maryam, de la Fuente, Sonia, Houbraken, Jos, Risslegger, Brigitte, Lass-Flörl, Cornelia, and Lackner, Michaela

Abstract

Objectives: Invasive mold infections associated with Aspergillus species are a significant cause of mortality in immunocompromised patients. The most frequently occurring aetiological pathogens are members of the Aspergillus section Fumigati followed by members of the section Terrei. The frequency of Aspergillus terreus and related (cryptic) species in clinical specimens, as well as the percentage of azole-resistant strains remains to be studied. Methods: A global set (n = 498) of A. terreus and phenotypically related isolates was molecularly identified (beta-tubulin), tested for antifungal susceptibility against posaconazole, voriconazole, and itraconazole, and resistant phenotypes were correlated with point mutations in the cyp51A gene. Results: The majority of isolates was identified as A. terreus (86.8%), followed by A. citrinoterreus (8.4%), A. hortai (2.6%), A. alabamensis (1.6%), A. neoafricanus (0.2%), and A. floccosus (0.2%). One isolate failed to match a known Aspergillus sp., but was found most closely related to A. alabamensis. According to EUCAST clinical breakpoints azole resistance was detected in 5.4% of all tested isolates, 6.2% of A. terreus sensu stricto (s.s.) were posaconazole-resistant. Posaconazole resistance differed geographically and ranged from 0% in the Czech Republic, Greece, and Turkey to 13.7% in Germany. In contrast, azole resistance among cryptic species was rare 2 out of 66 isolates and was observed only in one A. citrinoterreus and one A. alabamensis isolate. The most affected amino acid position of the Cyp51A gene correlating with the posaconazole resistant phenotype was M217, which was found in the variation M217T and M217V. Conclusions: Aspergillus terreus was most prevalent, followed by A. citrinoterreus. Posaconazole was the most potent drug against A. terreus, but 5.4% of A. terreus sensu stricto showed resistance against this azole. In Austria, Germany, and the United Kingdom posaconazole-resistance i

Published
2018

30. Mycoplasma hominis Induces Mediastinitis after a Tonsillar Abscess

Author

Grancini, Anna, Colosimo, Manuela, Restelli, Antonella, Colombo, Rosaria, Maraschini, Anna, Pozzi, Cristina, Breda, Giuseppe, Protti, Alessandro, Arghittu, Milena, Gallelli, Luca, and Maiavacca, Rita

Subjects
stomatognathic system, Article Subject
Abstract

Mycoplasma hominis is commonly involved in genitourinary tract infections. We report a 59-year-old man who developed a M. hominis-associated mediastinitis following acute tonsillar infection.

Published
2016
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31. Yeast-like filamentous fungi: Molecular identification and in vitro susceptibility study.

Author

Esposto, Maria Carmela, Prigitano, Anna, Cascio, Giuliana Lo, Ossi, Cristina, Grancini, Anna, Cavanna, Caterina, Lallitto, Fabiola, Tejada, Milvana, Bandettini, Roberto, Mularoni, Alessandra, and Tortorano, Anna Maria

Abstract

Yeast-like filamentous fungi, collected in Italy from 1985 to 2018, were submitted to molecular identification and antifungal susceptibility testings. Clinical isolates were identified as  Magnusiomyces capitatus (28), M. clavatus  (18), and Geotrichum candidum (2).  M. clavatus  was prevalent among blood isolates (18/24),  M. capitatus  among isolates from other biological materials. The intrinsic echinocandin resistance was confirmed. Both species had low minimum inhibitory concentrations (MICs) of itraconazole, posaconazole, and voriconazole, while  M. clavatus  had lower MIC of flucytosine and higher MIC of isavuconazole than  M. capitatus. The intrinsic resistance of these species to echinocandins could be the reason of the recent increase of M. clavatus bloodstream infections. [ABSTRACT FROM AUTHOR]

Published
2019
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33. A prospective international Aspergillus terreus survey: an EFISG, ISHAM and ECMM joint study

Author

Risslegger, Brigitte, Zoran, Tamara, Lackner, Michaela, Aigner, María, Sanchez Reus, Ferrán, Rezusta, Antonio, Chowdhary, Anuradha, Alcacer Sanchez, Juan Manuel, Taj Aldeen, Saad Jaber, Arendrup, Maiken C., Oliveri, Salvatore, Kontoyiannis, Dimitrios P., Alastruey Izquierdo, Ana, Lagrou, Katrien, Lo Cascio, Giuliana, Meis, Jacques F., Buzina, Walter, Farina, Claudio, Drogari Apiranthitou, Miranda, Grancini, Anna, Tortorano, Anna Maria, Willinger, Birgit, Hamprecht, Axel, Johnson, Elizabeth, Klingspor, Lena, Arsic Arsenijevic, Valentina, Cornely, Oliver A., Meletiadis, Joseph, Prammer, Wolfgang, Tullio, Vivian, Vehreschild, Jörg Janne, Trovato, Laura, Lewis, Russell E., Segal, Esther, Rath, Peter Michael, Hamal, Petr, Rodríguez Iglesias, Manuel, Roilides, Emmanuel, Arikan Akdagli, Sevtap, Chakrabarti, Arunaloke, Colombo, Arnaldo L., Fernández, Mariana Soledad, Martin Gomez, M. Teresa, Badali, Hamid, Petrikkos, Georgios, Klimko, Nikolai, Heimann, Sebastian M., Houbraken, Jos, Uzun, Omrum, Edlinger, Michael, de la Fuente, Sonia, Lass Flörl, Cornelia, İç Hastalıkları, Risslegger, B., Zoran, T., Lackner, M., Aigner, M., Sã¡nchez-reus, F., Rezusta, A., Chowdhary, A., Taj-aldeen, S. J., Arendrup, M. C., Oliveri, S., Kontoyiannis, D. P., Alastruey-izquierdo, A., Lagrou, K., Lo Cascio, G., Meis, J. F., Buzina, W., Farina, C., Drogari-apiranthitou, M., Grancini, A., Tortorano, A. M., Willinger, B., Hamprecht, A., Johnson, E., Klingspor, L., Arsic-arsenijevic, V., Cornely, O. A., Meletiadis, J., Prammer, W., Tullio, V., Vehreschild, J. -. J., Trovato, L., Lewis, RUSSEL EDWARD, Segal, E., Rath, P. -. M., Hamal, P., Rodriguez-iglesias, M., Roilides, E., Arikan-akdagli, S., Chakrabarti, A., Colombo, A. L., Fernã¡ndez, M. S., Martin-gomez, M. T., Badali, H., Petrikkos, G., Klimko, N., Heimann, S. M., Houbraken, J., Uzun, O., Edlinger, M., Fuente, S. De La, Lass-flã¶rl, C., Westerdijk Fungal Biodiversity Institute, and Westerdijk Fungal Biodiversity Institute - Food and Indoor Mycology

Subjects
0301 basic medicine, Antifungal Agents, Medizin, Aspergillosis, purl.org/becyt/ford/1 [https], In vitrosusceptibility, Amphotericin B, Prevalence, Aspergillus terreus, Prospective Studies, skin and connective tissue diseases, biology, General Medicine, Aspergillus terreu, 3. Good health, Crytic species, Europe, Microbiology (medical), Infectious Diseases, Aspergillus, Epidemiological Monitoring, CIENCIAS NATURALES Y EXACTAS, medicine.drug, Species complex, Surveillance study, Crytic specie, Otras Ciencias Biológicas, Aspergillosi, 030106 microbiology, Microbial Sensitivity Tests, Microbiology, Ciencias Biológicas, 03 medical and health sciences, medicine, Humans, purl.org/becyt/ford/1.6 [https], in vitro susceptibility, Amphotericin B, Aspergillosis, Aspergillus terreus, crytic species, in vitro susceptibility, biology.organism_classification, medicine.disease, bacterial infections and mycoses, 030104 developmental biology, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]
Abstract

Objectives: A prospective international multicentre surveillance study was conducted to investigate the prevalence and amphotericin B susceptibility of Aspergillus terreus species complex infections. Methods: A total of 370 cases from 21 countries were evaluated. Results: The overall prevalence of A. terreus species complex among the investigated patients with mould-positive cultures was 5.2% (370/7116). Amphotericin B MICs ranged from 0.125 to 32 mg/L, (median 8 mg/L). Conclusions: Aspergillus terreus species complex infections cause a wide spectrum of aspergillosis and the majority of cryptic species display high amphotericin B MICs. Fil: Risslegger, Brigitte. Universidad de Innsbruck; Austria Fil: Zoran, Tamara. Universidad de Innsbruck; Austria Fil: Lackner, Michaela. Universidad de Innsbruck; Austria Fil: Aigner, María. Universidad de Innsbruck; Austria Fil: Sanchez Reus, Ferrán. Hospital de la Santa Creu I Sant Pau; España Fil: Rezusta, Antonio. Universidad de Zaragoza; España Fil: Chowdhary, Anuradha. University of Delhi; India Fil: Alcacer Sanchez, Juan Manuel. Hospital de la Santa Creu I Sant Pau; Fil: Taj Aldeen, Saad Jaber. Hamad Medical Corporation; Qatar Fil: Arendrup, Maiken C.. Universidad de Copenhagen; Dinamarca Fil: Oliveri, Salvatore. Università degli Studi di Catania; Italia Fil: Kontoyiannis, Dimitrios P.. The University of Texas MD Anderson Cancer Center; Estados Unidos Fil: Alastruey Izquierdo, Ana. Universidad Carlos III de Madrid. Instituto de Salud; España Fil: Lagrou, Katrien. Katholikie Universiteit Leuven; Bélgica Fil: Lo Cascio, Giuliana. Azienda Ospedaliera Universitaria Integrata; Italia Fil: Meis, Jacques F.. Canisius Wilhelmina Hospital; Países Bajos Fil: Buzina, Walter. Medical University of Graz; Austria Fil: Farina, Claudio. ASST Papa Giovanni XXIII. Microbiology Institute; Italia Fil: Drogari Apiranthitou, Miranda. Universidad Nacional y Kapodistriaca de Atenas; Grecia Fil: Grancini, Anna. Cà Granda Ospedale Maggiore Policlinico; Italia Fil: Tortorano, Anna Maria. Università degli Studi di Milano; Italia Fil: Willinger, Birgit. Universidad de Viena; Austria Fil: Hamprecht, Axel. Universitat Zu Köln; Alemania Fil: Johnson, Elizabeth. Public Health England. Mycology Reference Laboratory; Reino Unido Fil: Klingspor, Lena. Karolinska Huddinge Hospital; Suecia Fil: Arsic Arsenijevic, Valentina. University of Belgrade; Serbia Fil: Cornely, Oliver A.. Universitat Zu Köln; Alemania Fil: Meletiadis, Joseph. Universidad Nacional y Kapodistriaca de Atenas; Grecia Fil: Prammer, Wolfgang. Klinikum Wels-Grieskirchen; Austria Fil: Tullio, Vivian. Università di Torino; Italia Fil: Vehreschild, Jörg Janne. Universitat Bonn; Alemania. Universitat Zu Köln; Alemania Fil: Trovato, Laura. Università degli Studi di Catania; Italia Fil: Lewis, Russell E.. Universidad de Bologna; Italia Fil: Segal, Esther. Tel Aviv University; Israel Fil: Rath, Peter Michael. Universitat Essen; Alemania Fil: Hamal, Petr. Universtity Hospital Olomouc; República Checa. Palacky University Olomouc; República Checa Fil: Rodríguez Iglesias, Manuel. Universidad de Cádiz; España Fil: Roilides, Emmanuel. Aristotle University School of Health Sciences; Grecia Fil: Arikan Akdagli, Sevtap. Hacettepe University; Turquía Fil: Chakrabarti, Arunaloke. Postgraduate Institute of Medical Education and Research; India Fil: Colombo, Arnaldo L.. Universidade Federal de Sao Paulo; Brasil Fil: Fernández, Mariana Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Martin Gomez, M. Teresa. Vall d’Hebron University Hospital; España Fil: Badali, Hamid. Mazandaran University of Medical Sciences; Irán Fil: Petrikkos, Georgios. European University Cyprus; Chipre Fil: Klimko, Nikolai. North Western State Medical University; Rusia Fil: Heimann, Sebastian M.. Universitat Zu Köln; Alemania Fil: Houbraken, Jos. Fungal Biodiversity Centre; Países Bajos Fil: Uzun, Omrum. Hacettepe University Medical School; Turquía Fil: Edlinger, Michael. Universidad de Innsbruck; Austria Fil: de la Fuente, Sonia. Hospital Ernest Lluch Martin; España Fil: Lass Flörl, Cornelia. Universidad de Innsbruck; Austria

Published
2017
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34. Genital-oral transmission of Candida lusitaniae

Author

Veraldi, Stefano, Bortoluzzi, Paolo, Germiniasi, Francesca, and Grancini, Anna

Abstract

Candida lusitaniaeis a vaginal commensal. Cases of vaginitis, vulvovaginitis and recurrent vulvovaginitis caused by this yeast are very rare. In the oral cavity, C. lusitaniaecauses stomatitis in immunocompromised patients. We describe a case of stomatitis and angular cheilitis caused by C. lusitaniaein a female patient with type 2 diabetes. The infection was most likely transmitted following genital-oral intercourse with the patient’s girlfriend, who was affected by C. lusitaniaevulvovaginitis.

Published
2024
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40. Cross-Reactivity of Fusariumspp. in the AspergillusGalactomannan Enzyme-Linked Immunosorbent Assay

Author

Tortorano, Anna Maria, Esposto, Maria Carmela, Prigitano, Anna, Grancini, Anna, Ossi, Cristina, Cavanna, Caterina, and Cascio, Giuliana Lo

Abstract

ABSTRACTNine of 11 hematological patients with disseminated/deep-seated Fusariuminfection tested at least twice for Aspergillusgalactomannan (GM) had repeated positive results in the absence of Aspergillusisolation in culture. The centrifuged supernatants of 12 Fusariumisolates were tested by a GM enzyme-linked immunosorbent assay (EIA). All the isolates produced positive reactions when tested undiluted. These results show cross-reactivity of Fusariumspp. with AspergillusGM that may constitute a drawback with respect to the specificity of the Platelia EIA.

Published
2012
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41. Species Distribution and In Vitro Antifungal Susceptibility Patterns of 75 Clinical Isolates of Fusariumspp. from Northern Italy

Author

Tortorano, Anna Maria, Prigitano, Anna, Dho, Giovanna, Esposto, Maria Carmela, Gianni, Claudia, Grancini, Anna, Ossi, Cristina, and Viviani, Maria Anna

Abstract

ABSTRACTFusariumisolates from 75 Italian patients were identified by molecular methods, and their susceptibilities to antifungals were tested in vitro. Fusarium verticillioideswas the species most frequently isolated from deep-seated infections, and F. solaniwas the species most frequently isolated from superficial infections. F. solaniisolates showed high azole MICs, while F. verticillioidesisolates showed low posaconazole MICs.

Published
2008
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42. Mycetoma Caused by Aspergillus nidulans.

Author

Veraldi, Stefano, Grancini, Anna, Venegoni, Luigia, Merlo, Valentina, Guanziroli, Elena, Menicanti, Claudia, Nazzaro, Gianluca, and Tortorano, Annamaria

Subjects
*MYCETOMA, *ASPERGILLUS nidulans, *SYMPTOMS, *HISTORY of medicine, *THERAPEUTICS
Abstract

The article describes the case of a patient with mycetoma caused by Aspergillus nidulans. It discusses the characteristics of Aspergillys nidulans, symptoms experienced by the patient, the patient's medical history, results of the patient's histopathological or mycological examination, and treatment received by the patient.

Published
2016
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43. Safety of rezafungin as a long-term treatment option in two patients with complicated fungal infections: two cases from Lecco Hospital (Italy).

Author

Ponta G, Morena V, Strano M, Molteni C, Pontiggia S, Cavalli EM, Grancini A, Mauri C, Castagna A, Galanti A, and Piconi S

Subjects
Humans, Candidiasis drug therapy, Candidiasis microbiology, Drug Resistance, Fungal, Endocarditis drug therapy, Endocarditis microbiology, Italy, Osteomyelitis drug therapy, Osteomyelitis microbiology, Antifungal Agents therapeutic use, Echinocandins therapeutic use
Abstract

Rezafungin is an echinocandin characterized by a long elimination half-life which allows for weekly administration. It has been recently approved for the treatment of candidemia. Few data are available about the long-term use of rezafungin and its use for deep infections like endocarditis and osteomyelitis. We describe our experience with its prolonged use in two azole-resistant Candida infections: a case of sacral osteomyelitis and a prosthetic valve endocarditis also involving a thoracic endovascular aneurysm repair., Competing Interests: The authors declare no conflict of interest.

Published
2024
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44. Evaluation of Real Time PCR Aspergillus spp. in bronchoalveolar lavage samples.

Author

Grancini A, Orlandi A, Lunghi G, Consonni D, Pozzi C, Rossetti V, Palleschi A, Fracchiolla N, Melada E, Savioli M, Arghittu M, Maiavacca R, and Prigitano A

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Child, DNA, Fungal genetics, DNA, Fungal isolation & purification, Humans, Middle Aged, Sensitivity and Specificity, Young Adult, Aspergillus isolation & purification, Bronchoalveolar Lavage Fluid microbiology, Pulmonary Aspergillosis diagnosis, Real-Time Polymerase Chain Reaction methods
Abstract

The present study investigated the improvement in the diagnosis of invasive pulmonary aspergillosis (IPA) adding a molecular test on bronchoalveolar lavage (BAL) to the routine diagnostic approach including microscopy, culture and galactomannan (GM) immunoassay. A total of 133 BAL samples were retrospectively tested for the Aspergillus DNA: 112 samples were from immunocompromised patients at risk of invasive fungal infection and 21 were from patients not at risk and without clinical evidence of IPA. The latter samples were used to identify the cut-off of positivity for the molecular test. Applying the cut-off quantity of 50 copies/reaction, the PCR test had 90% sensitivity and 97% specificity and resulted the most sensitive, specific and accurate among those evaluated. The statistical analysis showed that the probability that a patient is not affected by IPA is 99% when the three tests (PCR, GM and culture) are concordantly negative.

Published
2018

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