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219 results on '"Granato F"'

1. Effective field theory interactions for liquid argon target in DarkSide-50 experiment

Author: Collaboration, The DarkSide-50, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Ave, M., Back, H. O., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W. M., Bottino, B., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Chepurnov, A., Cicalò, C., Cocco, A. G., Covone, G., D'Angelo, D., Davini, S., DeCandia, A., DeCecco, S., DeDeo, M., DeFilippis, G., DeRosa, G., Derbin, A. V., Devoto, A., DiEusanio, F., D'Incecco, M., DiPietro, G., Dionisi, C., Downing, M., D'Urso, D., Edkins, E., Empl, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Galbiati, C., Ghiano, C., Giagu, S., Giganti, C., Giovanetti, G. K., Gorchakov, O., Goretti, A. M., Granato, F., Grobov, A., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B. R., Herner, K., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, Al., Ianni, An., Ippolito, V., Johnson, T. N., Keeter, K., Kendziora, C. L., Kochanek, I., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., LaCommara, M., Lai, M., Li, X., Lissia, M., Longo, G., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Mari, S. M., Maricic, J., Martoff, C. J., Messina, A., Meyers, P. D., Milincic, R., Monte, A., Morrocchi, M., Muratova, V. N., Musico, P., NavrerAgasson, A., Nozdrina, A. O., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Picciau, E., Pocar, A., Pordes, S., Poudel, S. S., Qian, H., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Savarese, C., Schlitzer, B., Segreto, E., Semenov, D. A., Shchagin, A., Sheshukov, A., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, R. B., Wada, M., Waldrop, T. J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., and Zuzel, G.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract: We reanalize data collected with the DarkSide-50 experiment and recently used to set limits on the spin-independent interaction rate of weakly interacting massive particles (WIMPs) on argon nuclei with an effective field theory framework. The dataset corresponds to a total (16660 $\pm$ 270) kg d exposure using a target of low-radioactivity argon extracted from underground sources. We obtain upper limits on the effective couplings of the 12 leading operators in the nonrelativistic systematic expansion. For each effective coupling we set constraints on WIMP-nucleon cross sections, setting upper limits between $2.4 \times 10^{-45} \, \mathrm{cm}^2$ and $2.3 \times 10^{-42} \, \mathrm{cm}^2$ (8.9 $\times 10^{-45} \, \mathrm{cm}^2$ and 6.0 $\times 10^{-42} \, \mathrm{cm}^2$) for WIMPs of mass of 100 $\mathrm{GeV/c^2}$ (1000 $\mathrm{GeV/c^2}$) at 90\% confidence level., Comment: Accepted by PRD
Published: 2020

2. Design and construction of a new detector to measure ultra-low radioactive-isotope contamination of argon

Author: The DarkSide Collaboration, Aalseth, C. E., Abdelhakim, S., Acerbi, F., Agnes, P., Ajaj, R., Albuquerque, I. F. M., Alexander, T., Alici, A., Alton, A. K., Amaudruz, P., Ameli, F., Anstey, J., Antonioli, P., Arba, M., Arcelli, S., Ardito, R., Arnquist, I. J., Arpaia, P., Asner, D. M., Asunskis, A., Ave, M., Back, H. O., Olmedo, A. Barrado, Batignani, G., Bisogni, M. G., Bocci, V., Bondar, A., Bonfini, G., Bonivento, W., Borisova, E., Bottino, B., Boulay, M. G., Bunker, R., Bussino, S., Buzulutskov, A., Cadeddu, M., Cadoni, M., Caminata, A., Canci, N., Candela, A., Cantini, C., Caravati, M., Cariello, M., Carnesecchi, F., Carpinelli, M., Castellani, A., Castello, P., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavazza, D., Cavuoti, S., Cebrian, S., Ruiz, J. M. Cela, Celano, B., Cereseto, R., Cheng, W., Chepurnov, A., Cicalò, C., Cifarelli, L., Citterio, M., Cocco, A. G., Cocco, V., Colocci, M., Consiglio, L., Cossio, F., Covone, G., Crivelli, P., D'Antone, I., D'Incecco, M., D'Urso, D., Rolo, M. D. Da Rocha, Dadoun, O., Daniel, M., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Falco, A., De Filippis, G., De Gruttola, D., De Guido, G., De Rosa, G., Dellacasa, G., Demontis, P., DePaquale, S., Derbin, A. V., Devoto, A., Di Eusanio, F., Di Noto, L., Di Pietro, G., Di Stefano, P., Dionisi, C., Dolganov, G., Dordei, F., Downing, M., Edalatfar, F., Empl, A., Diaz, M. Fernandez, Ferri, A., Filip, C., Fiorillo, G., Fomenko, K., Franceschi, A., Franco, D., Froudakis, G. E., Gabriele, F., Gabrieli, A., Galbiati, C., Abia, P. Garcia, Fora, D. Gascón, Gendotti, A., Ghiano, C., Ghisi, A., Giagu, S., Giampa, P., Giampaolo, R. A., Giganti, C., Giorgi, M. A., Giovanetti, G. K., Gligan, M. L., Gola, A., Gorchakov, O., Grab, M., Diaz, R. Graciani, Granato, F., Grassi, M., Grate, J. W., Grigoriev, G. Y., Grobov, A., Gromov, M., Guan, M., Guerra, M. B. B., Guerzoni, M., Gulino, M., Haaland, R. K., Hackett, B. R., Hallin, A., Harrop, B., Hoppe, E. W., Horikawa, S., Hosseini, B., Hubaut, F., Humble, P., Hungerford, E. V., Ianni, An., Ilyasov, A., Ippolito, V., Jillings, C., Keeter, K., Kendziora, C. L., Kim, S., Kochanek, I., Kondo, K., Kopp, G., Korablev, D., Korga, G., Kubankin, A., Kugathasan, R., Kuss, M., Kuźniak, M., La Commara, M., La Delfa, L., Lai, M., Langrock, S., Lebois, M., Lehnert, B., Levashko, N., Li, X., Liqiang, Q., Lissia, M., Lodi, G. U., Longo, G., Manzano, R. López, Lussana, R., Luzzi, L., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Marcante, M., Margotti, A., Mari, S. M., Mariani, M., Maricic, J., Marinelli, M., Marras, D., Martínez, M., Morales, J. J. Martínez, Rojas, A. D. Martinez, Martoff, C. J., Mascia, M., Mason, J., Masoni, A., Mazzi, A., McDonald, A. B., Messina, A., Meyers, P. D., Miletic, T., Milincic, R., Moggi, A., Moioli, S., Monroe, J., Morrocchi, M., Mroz, T., Mu, W., Muratova, V. N., Murphy, S., Muscas, C., Musico, P., Nania, R., Napolitano, T., Agasson, A. Navrer, Nessi, M., Nikulin, I., Oleinik, A., Oleynikov, V., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Palmas, S., Pandola, L., Pantic, E., Paoloni, E., Paternoster, G., Pavletcov, V., Pazzona, F., Peeters, S., Pegoraro, P. A., Pelczar, K., Pellegrini, L. A., Pellegrino, C., Pelliccia, N., Perotti, F., Pesudo, V., Picciau, E., Piemonte, C., Pietropaolo, F., Pocar, A., Pollman, T., Portaluppi, D., Poudel, S. S., Pralavorio, P., Price, D., Radics, B., Raffaelli, F., Ragusa, F., Razeti, M., Razeto, A., Regazzoni, V., Regenfus, C., Renshaw, A. L., Rescia, S., Rescigno, M., Retiere, F., Rignanese, L. P., Rivetti, A., Romani, A., Romero, L., Rossi, N., Rubbia, A., Sablone, D., Sala, P., Salatino, P., Samoylov, O., García, E. Sánchez, Sanfilippo, S., Sant, M., Santone, D., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Scioli, G., Segreto, E., Seifert, A., Semenov, D. A., Shchagin, A., Sheshukov, A., Siddhanta, S., Simeone, M., Singh, P. N., Skensved, P., Skorokhvatov, M. D., Smirnov, O., Sobrero, G., Sokolov, A., Sotnikov, A., Stainforth, R., Steri, A., Stracka, S., Strickland, V., Suffritti, G. B., Sulis, S., Suvorov, Y., Szelc, A. M., Tartaglia, R., Testera, G., Thorpe, T., Tonazzo, A., Tosi, A., Tuveri, M., Unzhakov, E. V., Usai, G., Vacca, A., Vázquez-Jáuregui, E., Verducci, M., Viant, T., Viel, S., Villa, F., Vishneva, A., Vogelaar, R. B., Wada, M., Wahl, J., Walding, J. J., Wang, H., Wang, Y., Westerdale, S., Wheadon, R. J., Williams, R., Wilson, J., Wojcik, Marcin, Wojcik, Mariusz, Wu, S., Xiao, X., Yang, C., Ye, Z., Zuffa, M., and Zuzel, G.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract: Large liquid argon detectors offer one of the best avenues for the detection of galactic weakly interacting massive particles (WIMPs) via their scattering on atomic nuclei. The liquid argon target allows exquisite discrimination between nuclear and electron recoil signals via pulse-shape discrimination of the scintillation signals. Atmospheric argon (AAr), however, has a naturally occurring radioactive isotope, $^{39}$Ar, a $\beta$ emitter of cosmogenic origin. For large detectors, the atmospheric $^{39}$Ar activity poses pile-up concerns. The use of argon extracted from underground wells, deprived of $^{39}$Ar, is key to the physics potential of these experiments. The DarkSide-20k dark matter search experiment will operate a dual-phase time projection chamber with 50 tonnes of radio-pure underground argon (UAr), that was shown to be depleted of $^{39}$Ar with respect to AAr by a factor larger than 1400. Assessing the $^{39}$Ar content of the UAr during extraction is crucial for the success of DarkSide-20k, as well as for future experiments of the Global Argon Dark Matter Collaboration (GADMC). This will be carried out by the DArT in ArDM experiment, a small chamber made with extremely radio-pure materials that will be placed at the centre of the ArDM detector, in the Canfranc Underground Laboratory (LSC) in Spain. The ArDM LAr volume acts as an active veto for background radioactivity, mostly $\gamma$-rays from the ArDM detector materials and the surrounding rock. This article describes the DArT in ArDM project, including the chamber design and construction, and reviews the background required to achieve the expected performance of the detector., Comment: 13 pages, 8 figures. Corresponding author: E. S\'anchez Garc\'ia
Published: 2020
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3. Measurement of the ion fraction and mobility of $^{218}$Po produced in $^{222}$Rn decays in liquid argon

Author: Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Ave, M., Back, H. O., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W. M., Bottino, B., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Chepurnov, A., Cicalo, C., Cocco, A. G., Covone, G., D'Angelo, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., Derbin, A. V., Devoto, A., Di Eusanio, F., D'Incecco, M., Di Pietro, G., Dionisi, C., Downing, M., D'Urso, D., Edkins, E., Empl, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Galbiati, C., Ghiano, C., Giagu, S., Giganti, C., Giovanetti, G. K., Gorchakov, O., Goretti, A. M., Granato, F., Grobov, A., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B. R., Herner, K., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, Al., Ianni, An., Ippolito, V., Johnson, T. N., Keeter, K., Kendziora, C. L., Kochanek, I., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Mari, S. M., Maricic, J., Martoff, C. J., Messina, A., Meyers, P. D., Milincic, R., Monte, A., Morrocchi, M., Muratova, V. N., Musico, P., Agasson, A. Navrer, Nozdrina, A. O., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Picciau, E., Pocar, A., Pordes, S., Poudel, S. S., Qian, H., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Savarese, C., Schlitzer, B., Segreto, E., Semenov, D. A., Shchagin, A., Sheshukov, A., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, R. B., Wada, M., Waldrop, T. J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., and Zuzel, G.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract: We report measurements of the charged daughter fraction of $^{218}$Po as a result of the $^{222}$Rn alpha decay, and the mobility of $^{218}$Po$^+$ ions, using radon-polonium coincidences from the $^{238}$U chain identified in 532 live-days of DarkSide-50 WIMP-search data. The fraction of $^{218}$Po that is charged is found to be 0.37$\pm$0.03 and the mobility of $^{218}$Po$^+$ is (8.6$\pm$0.1)$\times$10$^{-4}$$\frac{\text{cm}^2}{\text{Vs}}$.
Published: 2019
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4. Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling

Author: Hobor, S, Al Bakir, M, Hiley, C, Skrzypski, M, Frankell, A, Bakker, B, Watkins, T, Markovets, A, Dry, J, Brown, A, van der Aart, J, van den Bos, H, Spierings, D, Oukrif, D, Novelli, M, Chakrabarti, T, Rabinowitz, A, Ait Hassou, L, Litiere, S, Kerr, D, Tan, L, Kelly, G, Moore, D, Renshaw, M, Venkatesan, S, Hill, W, Huebner, A, Martinez-Ruiz, C, Black, J, Wu, W, Angelova, M, Mcgranahan, N, Downward, J, Chmielecki, J, Barrett, C, Litchfield, K, Chew, S, Blakely, C, de Bruin, E, Foijer, F, Vousden, K, Bivona, T, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Tufail, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Fennell, D, Matharu, G, Shaw, J, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, French, J, Gilbert, K, Naidu, B, Patel, A, Osman, A, Enstone, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totton, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Paiva-Correia, A, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Brown, K, Carter, M, Chaturvedi, A, Oliveira, P, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Dive, C, Aerts, H, Schwarz, R, Kaufmann, T, Wilson, G, Rosenthal, R, Van Loo, P, Birkbak, N, Szallasi, Z, Kisistok, J, Sokac, M, Salgado, R, Diossy, M, Demeulemeester, J, Bunkum, A, Dwornik, A, Magness, A, Rowan, A, Karamani, A, Toncheva, A, Chain, B, Castignani, C, Bailey, C, Abbosh, C, Puttick, C, Weeden, C, Lee, C, Richard, C, Naceur-Lombardelli, C, Pearce, D, Karagianni, D, Biswas, D, Levi, D, Larose Cadieux, E, Lim, E, Colliver, E, Nye, E, Galvez-Cancino, F, Gimeno-Valiente, F, Kassiotis, G, Stavrou, G, Mastrokalos, G, Lowe, H, Matos, I, Noorani, I, Goldman, J, Reading, J, Rane, J, Nicod, J, Hartley, J, Peggs, K, Enfield, K, Selvaraju, K, Thol, K, Ng, K, Chen, K, Dijkstra, K, Grigoriadis, K, Thakkar, K, Ensell, L, Shah, M, Litovchenko, M, Jamal-Hanjani, M, Werner Sunderland, M, Huska, M, Hill, M, Dietzen, M, Leung, M, Escudero, M, Tanic, M, Sivakumar, M, Chervova, O, Lucas, O, Pich, O, Al-Sawaf, O, Prymas, P, Hobson, P, Pawlik, P, Stone, R, Bentham, R, Vendramin, R, Saghafinia, S, Gamble, S, Veeriah, S, Ung, S, Quezada, S, Vanloo, S, Hessey, S, Ward, S, Harries, S, Boeing, S, Beck, S, Bola, S, Karasaki, T, Denner, T, Marafioti, T, Jones, T, Spanswick, V, Barbe, V, Lu, W, Liu, W, Wu, Y, Naito, Y, Ramsden, Z, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Forster, M, Lee, S, Borg, E, Falzon, M, Papadatos-Pastos, D, Wilson, J, Ahmad, T, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Janes, S, Martinoni Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Gorman, P, Khiroya, R, Stephens, R, Wong, Y, Kaplar, Z, Bandula, S, Hackshaw, A, Hacker, A, Sharp, A, Smith, S, Kaur Dhanda, H, Pilotti, C, Leslie, R, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Yuan, Y, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Cave, J, Richards, J, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Nicholson, A, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Kidd, A, Dick, C, Le Quesne, J, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Hynds, R, Kanu, N, Zaccaria, S, Gronroos, E, Swanton, C, Hobor S., Al Bakir M., Hiley C. T., Skrzypski M., Frankell A. M., Bakker B., Watkins T. B. K., Markovets A., Dry J. R., Brown A. P., van der Aart J., van den Bos H., Spierings D., Oukrif D., Novelli M., Chakrabarti T., Rabinowitz A. H., Ait Hassou L., Litiere S., Kerr D. L., Tan L., Kelly G., Moore D. A., Renshaw M. J., Venkatesan S., Hill W., Huebner A., Martinez-Ruiz C., Black J. R. M., Wu W., Angelova M., McGranahan N., Downward J., Chmielecki J., Barrett C., Litchfield K., Chew S. K., Blakely C. M., de Bruin E. C., Foijer F., Vousden K. H., Bivona T. G., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Tufail M., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Fennell D. A., Matharu G., Shaw J. A., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., French J., Gilbert K., Naidu B., Patel A. J., Osman A., Enstone C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totton N., Montero A., Smith E., Fontaine E., Granato F., Paiva-Correia A., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P. A. J., Brown K. D., Carter M., Chaturvedi A., Oliveira P., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Dive C., Aerts H. J. W. L., Schwarz R. F., Kaufmann T. L., Wilson G. A., Rosenthal R., Van Loo P., Birkbak N. J., Szallasi Z., Kisistok J., Sokac M., Salgado R., Diossy M., Demeulemeester J., Bunkum A., Dwornik A., Magness A., Rowan A. J., Karamani A., Toncheva A., Chain B., Castignani C., Bailey C., Abbosh C., Puttick C., Weeden C. E., Lee C., Richard C., Naceur-Lombardelli C., Pearce D. R., Karagianni D., Biswas D., Levi D., Larose Cadieux E., Lim E. L., Colliver E., Nye E., Galvez-Cancino F., Gimeno-Valiente F., Kassiotis G., Stavrou G., Mastrokalos G. -T., Lowe H. L., Matos I. G., Noorani I., Goldman J., Reading J. L., Rane J. K., Nicod J., Hartley J. A., Peggs K. S., Enfield K. S. S., Selvaraju K., Thol K., Ng K. W., Chen K., Dijkstra K., Grigoriadis K., Thakkar K., Ensell L., Shah M., Litovchenko M., Jamal-Hanjani M., Werner Sunderland M., Huska M. R., Hill M. S., Dietzen M., Leung M. M., Escudero M., Tanic M., Sivakumar M., Chervova O., Lucas O., Pich O., Al-Sawaf O., Prymas P., Hobson P., Pawlik P., Stone R. K., Bentham R., Vendramin R., Saghafinia S., Gamble S., Veeriah S., Ung S. K. A., Quezada S. A., Vanloo S., Hessey S., Ward S., Harries S., Boeing S., Beck S., Bola S. K., Karasaki T., Denner T., Marafioti T., Jones T. P., Spanswick V., Barbe V., Lu W. -T., Liu W. K., Wu Y., Naito Y., Ramsden Z., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Forster M. D., Lee S. M., Borg E., Falzon M., Papadatos-Pastos D., Wilson J., Ahmad T., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Janes S. M., Martinoni Hoogenboom E., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Gorman P., Khiroya R., Stephens R. C. M., Wong Y. N. S., Kaplar Z., Bandula S., Hackshaw A., Hacker A. -M., Sharp A., Smith S., Kaur Dhanda H., Pilotti C., Leslie R., Grapa A., Zhang H., AbdulJabbar K., Pan X., Yuan Y., Chuter D., MacKenzie M., Chee S., Alzetani A., Cave J., Richards J., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Nicholson A. G., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Kidd A., Dick C., Le Quesne J., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., Hynds R. E., Kanu N., Zaccaria S., Gronroos E., Swanton C., Hobor, S, Al Bakir, M, Hiley, C, Skrzypski, M, Frankell, A, Bakker, B, Watkins, T, Markovets, A, Dry, J, Brown, A, van der Aart, J, van den Bos, H, Spierings, D, Oukrif, D, Novelli, M, Chakrabarti, T, Rabinowitz, A, Ait Hassou, L, Litiere, S, Kerr, D, Tan, L, Kelly, G, Moore, D, Renshaw, M, Venkatesan, S, Hill, W, Huebner, A, Martinez-Ruiz, C, Black, J, Wu, W, Angelova, M, Mcgranahan, N, Downward, J, Chmielecki, J, Barrett, C, Litchfield, K, Chew, S, Blakely, C, de Bruin, E, Foijer, F, Vousden, K, Bivona, T, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Tufail, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Fennell, D, Matharu, G, Shaw, J, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, French, J, Gilbert, K, Naidu, B, Patel, A, Osman, A, Enstone, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totton, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Paiva-Correia, A, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Brown, K, Carter, M, Chaturvedi, A, Oliveira, P, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Dive, C, Aerts, H, Schwarz, R, Kaufmann, T, Wilson, G, Rosenthal, R, Van Loo, P, Birkbak, N, Szallasi, Z, Kisistok, J, Sokac, M, Salgado, R, Diossy, M, Demeulemeester, J, Bunkum, A, Dwornik, A, Magness, A, Rowan, A, Karamani, A, Toncheva, A, Chain, B, Castignani, C, Bailey, C, Abbosh, C, Puttick, C, Weeden, C, Lee, C, Richard, C, Naceur-Lombardelli, C, Pearce, D, Karagianni, D, Biswas, D, Levi, D, Larose Cadieux, E, Lim, E, Colliver, E, Nye, E, Galvez-Cancino, F, Gimeno-Valiente, F, Kassiotis, G, Stavrou, G, Mastrokalos, G, Lowe, H, Matos, I, Noorani, I, Goldman, J, Reading, J, Rane, J, Nicod, J, Hartley, J, Peggs, K, Enfield, K, Selvaraju, K, Thol, K, Ng, K, Chen, K, Dijkstra, K, Grigoriadis, K, Thakkar, K, Ensell, L, Shah, M, Litovchenko, M, Jamal-Hanjani, M, Werner Sunderland, M, Huska, M, Hill, M, Dietzen, M, Leung, M, Escudero, M, Tanic, M, Sivakumar, M, Chervova, O, Lucas, O, Pich, O, Al-Sawaf, O, Prymas, P, Hobson, P, Pawlik, P, Stone, R, Bentham, R, Vendramin, R, Saghafinia, S, Gamble, S, Veeriah, S, Ung, S, Quezada, S, Vanloo, S, Hessey, S, Ward, S, Harries, S, Boeing, S, Beck, S, Bola, S, Karasaki, T, Denner, T, Marafioti, T, Jones, T, Spanswick, V, Barbe, V, Lu, W, Liu, W, Wu, Y, Naito, Y, Ramsden, Z, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Forster, M, Lee, S, Borg, E, Falzon, M, Papadatos-Pastos, D, Wilson, J, Ahmad, T, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Janes, S, Martinoni Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Gorman, P, Khiroya, R, Stephens, R, Wong, Y, Kaplar, Z, Bandula, S, Hackshaw, A, Hacker, A, Sharp, A, Smith, S, Kaur Dhanda, H, Pilotti, C, Leslie, R, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Yuan, Y, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Cave, J, Richards, J, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Nicholson, A, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Kidd, A, Dick, C, Le Quesne, J, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Hynds, R, Kanu, N, Zaccaria, S, Gronroos, E, Swanton, C, Hobor S., Al Bakir M., Hiley C. T., Skrzypski M., Frankell A. M., Bakker B., Watkins T. B. K., Markovets A., Dry J. R., Brown A. P., van der Aart J., van den Bos H., Spierings D., Oukrif D., Novelli M., Chakrabarti T., Rabinowitz A. H., Ait Hassou L., Litiere S., Kerr D. L., Tan L., Kelly G., Moore D. A., Renshaw M. J., Venkatesan S., Hill W., Huebner A., Martinez-Ruiz C., Black J. R. M., Wu W., Angelova M., McGranahan N., Downward J., Chmielecki J., Barrett C., Litchfield K., Chew S. K., Blakely C. M., de Bruin E. C., Foijer F., Vousden K. H., Bivona T. G., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Tufail M., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Fennell D. A., Matharu G., Shaw J. A., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., French J., Gilbert K., Naidu B., Patel A. J., Osman A., Enstone C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totton N., Montero A., Smith E., Fontaine E., Granato F., Paiva-Correia A., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P. A. J., Brown K. D., Carter M., Chaturvedi A., Oliveira P., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Dive C., Aerts H. J. W. L., Schwarz R. F., Kaufmann T. L., Wilson G. A., Rosenthal R., Van Loo P., Birkbak N. J., Szallasi Z., Kisistok J., Sokac M., Salgado R., Diossy M., Demeulemeester J., Bunkum A., Dwornik A., Magness A., Rowan A. J., Karamani A., Toncheva A., Chain B., Castignani C., Bailey C., Abbosh C., Puttick C., Weeden C. E., Lee C., Richard C., Naceur-Lombardelli C., Pearce D. R., Karagianni D., Biswas D., Levi D., Larose Cadieux E., Lim E. L., Colliver E., Nye E., Galvez-Cancino F., Gimeno-Valiente F., Kassiotis G., Stavrou G., Mastrokalos G. -T., Lowe H. L., Matos I. G., Noorani I., Goldman J., Reading J. L., Rane J. K., Nicod J., Hartley J. A., Peggs K. S., Enfield K. S. S., Selvaraju K., Thol K., Ng K. W., Chen K., Dijkstra K., Grigoriadis K., Thakkar K., Ensell L., Shah M., Litovchenko M., Jamal-Hanjani M., Werner Sunderland M., Huska M. R., Hill M. S., Dietzen M., Leung M. M., Escudero M., Tanic M., Sivakumar M., Chervova O., Lucas O., Pich O., Al-Sawaf O., Prymas P., Hobson P., Pawlik P., Stone R. K., Bentham R., Vendramin R., Saghafinia S., Gamble S., Veeriah S., Ung S. K. A., Quezada S. A., Vanloo S., Hessey S., Ward S., Harries S., Boeing S., Beck S., Bola S. K., Karasaki T., Denner T., Marafioti T., Jones T. P., Spanswick V., Barbe V., Lu W. -T., Liu W. K., Wu Y., Naito Y., Ramsden Z., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Forster M. D., Lee S. M., Borg E., Falzon M., Papadatos-Pastos D., Wilson J., Ahmad T., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Janes S. M., Martinoni Hoogenboom E., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Gorman P., Khiroya R., Stephens R. C. M., Wong Y. N. S., Kaplar Z., Bandula S., Hackshaw A., Hacker A. -M., Sharp A., Smith S., Kaur Dhanda H., Pilotti C., Leslie R., Grapa A., Zhang H., AbdulJabbar K., Pan X., Yuan Y., Chuter D., MacKenzie M., Chee S., Alzetani A., Cave J., Richards J., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Nicholson A. G., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Kidd A., Dick C., Le Quesne J., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., Hynds R. E., Kanu N., Zaccaria S., Gronroos E., and Swanton C.
Abstract: The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an individual patient presents a challenging clinical scenario. Furthermore, the molecular basis of mixed intra-patient tumor responses remains unclear. Here, we show that patients with metastatic lung adenocarcinoma harbouring co-mutations of EGFR and TP53, are more likely to have mixed intra-patient tumor responses to EGFR tyrosine kinase inhibition (TKI), compared to those with an EGFR mutation alone. The combined presence of whole genome doubling (WGD) and TP53 co-mutations leads to increased genome instability and genomic copy number aberrations in genes implicated in EGFR TKI resistance. Using mouse models and an in vitro isogenic p53-mutant model system, we provide evidence that WGD provides diverse routes to drug resistance by increasing the probability of acquiring copy-number gains or losses relative to non-WGD cells. These data provide a molecular basis for mixed tumor responses to targeted therapy, within an individual patient, with implications for therapeutic strategies.
Published: 2024

5. The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma

Author: Pan, X, Abduljabbar, K, Coelho-Lima, J, Grapa, A, Zhang, H, Cheung, A, Baena, J, Karasaki, T, Wilson, C, Sereno, M, Veeriah, S, Aitken, S, Hackshaw, A, Nicholson, A, Jamal-Hanjani, M, Le Quesne, J, Janes, S, Hacker, A, Sharp, A, Smith, S, Dhanda, H, Chan, K, Pilotti, C, Leslie, R, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Lim, E, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Kidd, A, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Dick, C, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Tufail, M, Scotland, M, Boyles, R, Rathinam, S, Fennell, D, Marrone, D, Dulloo, S, Matharu, G, Shaw, J, Riley, J, Primrose, L, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, Papadatos-Pastos, D, Wilson, J, Ahmad, T, French, J, Gilbert, K, Naidu, B, Patel, A, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totten, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Paiva-Correia, A, Chaturvedi, A, Priest, L, Oliveira, P, Gomes, F, Brown, K, Carter, M, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Dive, C, Aerts, H, Schwarz, R, Kaufmann, T, Van Loo, P, Wilson, G, Rosenthal, R, Rowan, A, Bailey, C, Lee, C, Colliver, E, Enfield, K, Hill, M, Angelova, M, Pich, O, Leung, M, Frankell, A, Hiley, C, Zhai, H, Bakir, M, Birkbak, N, Lucas, O, Huebner, A, Puttick, C, Grigoriadis, K, Dietzen, M, Biswas, D, Athanasopoulou, F, Ward, S, Demeulemeester, J, Castignani, C, Cadieux, E, Kisistok, J, Sokac, M, Szallasi, Z, Diossy, M, Salgado, R, Stewart, A, Magness, A, Weeden, C, Levi, D, Gronroos, E, Noorani, I, Goldman, J, Escudero, M, Hobson, P, Vendramin, R, Boeing, S, Denner, T, Barbe, V, Lu, W, Hill, W, Naito, Y, Ramsden, Z, Kassiotis, G, Dwornik, A, Karamani, A, Chain, B, Pearce, D, Karagianni, D, Galvez-Cancino, F, Stavrou, G, Mastrokalos, G, Lowe, H, Matos, I, Reading, J, Hartley, J, Selvaraju, K, Chen, K, Ensell, L, Shah, M, Litovchenko, M, Chervova, O, Pawlik, P, Hynds, R, Gamble, S, Ung, S, Bola, S, Spanswick, V, Wu, Y, Al-Sawaf, O, Jones, T, Beck, S, Tanic, M, Marafioti, T, Borg, E, Falzon, M, Khiroya, R, Toncheva, A, Abbosh, C, Richard, C, Naceur-Lombardelli, C, Gimeno-Valiente, F, Thakkar, K, Sunderland, M, Sivakumar, M, Kanu, N, Prymas, P, Saghafinia, S, Vanloo, S, Lam, J, Liu, W, Bunkum, A, Hessey, S, Zaccaria, S, Martinez-Ruiz, C, Black, J, Thol, K, Bentham, R, Litchfield, K, Mcgranahan, N, Quezada, S, Forster, M, Lee, S, Herrero, J, Nye, E, Stone, R, Nicod, J, Rane, J, Peggs, K, Ng, K, Dijkstra, K, Huska, M, Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Gorman, P, Stephens, R, Wong, Y, Kaplar, Z, Bandula, S, Watkins, T, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Swanton, C, Yuan, Y, Moore, D, Pan X., AbdulJabbar K., Coelho-Lima J., Grapa A. -I., Zhang H., Cheung A. H. K., Baena J., Karasaki T., Wilson C. R., Sereno M., Veeriah S., Aitken S. J., Hackshaw A., Nicholson A. G., Jamal-Hanjani M., Le Quesne J., Janes S. M., Hacker A. -M., Sharp A., Smith S., Dhanda H. K., Chan K., Pilotti C., Leslie R., Chuter D., MacKenzie M., Chee S., Alzetani A., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Kidd A., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., Dick C., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Tufail M., Scotland M., Boyles R., Rathinam S., Fennell D. A., Wilson C., Marrone D., Dulloo S., Matharu G., Shaw J. A., Riley J., Primrose L., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., Papadatos-Pastos D., Wilson J., Ahmad T., French J., Gilbert K., Naidu B., Patel A. J., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totten N., Montero A., Smith E., Fontaine E., Granato F., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P., Paiva-Correia A., Chaturvedi A., Priest L., Oliveira P., Gomes F., Brown K., Carter M., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Dive C., Aerts H. J. W. L., Schwarz R. F., Kaufmann T. L., Van Loo P., Wilson G. A., Rosenthal R., Rowan A., Bailey C., Lee C., Colliver E., Enfield K. S. S., Hill M. S., Angelova M., Pich O., Leung M., Frankell A. M., Hiley C. T., Lim E. L., Zhai H., Bakir M. A., Birkbak N. J., Lucas O., Huebner A., Puttick C., Grigoriadis K., Dietzen M., Biswas D., Athanasopoulou F., Ward S., Demeulemeester J., Castignani C., Cadieux E. L., Kisistok J., Sokac M., Szallasi Z., Diossy M., Salgado R., Stewart A., Magness A., Weeden C. E., Levi D., Gronroos E., Noorani I., Goldman J., Escudero M., Hobson P., Vendramin R., Boeing S., Denner T., Barbe V., Lu W. -T., Hill W., Naito Y., Ramsden Z., Kassiotis G., Dwornik A., Karamani A., Chain B., Pearce D. R., Karagianni D., Galvez-Cancino F., Stavrou G., Mastrokalos G., Lowe H. L., Matos I. G., Reading J. L., Hartley J. A., Selvaraju K., Chen K., Ensell L., Shah M., Litovchenko M., Chervova O., Pawlik P., Hynds R. E., Gamble S., Ung S. K. A., Bola S. K., Spanswick V., Wu Y., Al-Sawaf O., Jones T. P., Beck S., Tanic M., Marafioti T., Borg E., Falzon M., Khiroya R., Toncheva A., Abbosh C., Richard C., Naceur-Lombardelli C., Gimeno-Valiente F., Thakkar K., Sunderland M. W., Sivakumar M., Kanu N., Prymas P., Saghafinia S., Vanloo S., Lam J. M., Liu W. K., Bunkum A., Hessey S., Zaccaria S., Martinez-Ruiz C., Black J. R. M., Thol K., Bentham R., Litchfield K., McGranahan N., Quezada S. A., Forster M. D., Lee S. M., Herrero J., Nye E., Stone R. K., Nicod J., Rane J. K., Peggs K. S., Ng K. W., Dijkstra K., Huska M. R., Hoogenboom E. M., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Gorman P., Stephens R. C. M., Wong Y. N. S., Kaplar Z., Bandula S., Watkins T. B. K., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Swanton C., Yuan Y., Moore D. A., Pan, X, Abduljabbar, K, Coelho-Lima, J, Grapa, A, Zhang, H, Cheung, A, Baena, J, Karasaki, T, Wilson, C, Sereno, M, Veeriah, S, Aitken, S, Hackshaw, A, Nicholson, A, Jamal-Hanjani, M, Le Quesne, J, Janes, S, Hacker, A, Sharp, A, Smith, S, Dhanda, H, Chan, K, Pilotti, C, Leslie, R, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Lim, E, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Kidd, A, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Dick, C, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Tufail, M, Scotland, M, Boyles, R, Rathinam, S, Fennell, D, Marrone, D, Dulloo, S, Matharu, G, Shaw, J, Riley, J, Primrose, L, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, Papadatos-Pastos, D, Wilson, J, Ahmad, T, French, J, Gilbert, K, Naidu, B, Patel, A, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totten, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Paiva-Correia, A, Chaturvedi, A, Priest, L, Oliveira, P, Gomes, F, Brown, K, Carter, M, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Dive, C, Aerts, H, Schwarz, R, Kaufmann, T, Van Loo, P, Wilson, G, Rosenthal, R, Rowan, A, Bailey, C, Lee, C, Colliver, E, Enfield, K, Hill, M, Angelova, M, Pich, O, Leung, M, Frankell, A, Hiley, C, Zhai, H, Bakir, M, Birkbak, N, Lucas, O, Huebner, A, Puttick, C, Grigoriadis, K, Dietzen, M, Biswas, D, Athanasopoulou, F, Ward, S, Demeulemeester, J, Castignani, C, Cadieux, E, Kisistok, J, Sokac, M, Szallasi, Z, Diossy, M, Salgado, R, Stewart, A, Magness, A, Weeden, C, Levi, D, Gronroos, E, Noorani, I, Goldman, J, Escudero, M, Hobson, P, Vendramin, R, Boeing, S, Denner, T, Barbe, V, Lu, W, Hill, W, Naito, Y, Ramsden, Z, Kassiotis, G, Dwornik, A, Karamani, A, Chain, B, Pearce, D, Karagianni, D, Galvez-Cancino, F, Stavrou, G, Mastrokalos, G, Lowe, H, Matos, I, Reading, J, Hartley, J, Selvaraju, K, Chen, K, Ensell, L, Shah, M, Litovchenko, M, Chervova, O, Pawlik, P, Hynds, R, Gamble, S, Ung, S, Bola, S, Spanswick, V, Wu, Y, Al-Sawaf, O, Jones, T, Beck, S, Tanic, M, Marafioti, T, Borg, E, Falzon, M, Khiroya, R, Toncheva, A, Abbosh, C, Richard, C, Naceur-Lombardelli, C, Gimeno-Valiente, F, Thakkar, K, Sunderland, M, Sivakumar, M, Kanu, N, Prymas, P, Saghafinia, S, Vanloo, S, Lam, J, Liu, W, Bunkum, A, Hessey, S, Zaccaria, S, Martinez-Ruiz, C, Black, J, Thol, K, Bentham, R, Litchfield, K, Mcgranahan, N, Quezada, S, Forster, M, Lee, S, Herrero, J, Nye, E, Stone, R, Nicod, J, Rane, J, Peggs, K, Ng, K, Dijkstra, K, Huska, M, Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Gorman, P, Stephens, R, Wong, Y, Kaplar, Z, Bandula, S, Watkins, T, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Swanton, C, Yuan, Y, Moore, D, Pan X., AbdulJabbar K., Coelho-Lima J., Grapa A. -I., Zhang H., Cheung A. H. K., Baena J., Karasaki T., Wilson C. R., Sereno M., Veeriah S., Aitken S. J., Hackshaw A., Nicholson A. G., Jamal-Hanjani M., Le Quesne J., Janes S. M., Hacker A. -M., Sharp A., Smith S., Dhanda H. K., Chan K., Pilotti C., Leslie R., Chuter D., MacKenzie M., Chee S., Alzetani A., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Kidd A., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., Dick C., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Tufail M., Scotland M., Boyles R., Rathinam S., Fennell D. A., Wilson C., Marrone D., Dulloo S., Matharu G., Shaw J. A., Riley J., Primrose L., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., Papadatos-Pastos D., Wilson J., Ahmad T., French J., Gilbert K., Naidu B., Patel A. J., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totten N., Montero A., Smith E., Fontaine E., Granato F., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P., Paiva-Correia A., Chaturvedi A., Priest L., Oliveira P., Gomes F., Brown K., Carter M., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Dive C., Aerts H. J. W. L., Schwarz R. F., Kaufmann T. L., Van Loo P., Wilson G. A., Rosenthal R., Rowan A., Bailey C., Lee C., Colliver E., Enfield K. S. S., Hill M. S., Angelova M., Pich O., Leung M., Frankell A. M., Hiley C. T., Lim E. L., Zhai H., Bakir M. A., Birkbak N. J., Lucas O., Huebner A., Puttick C., Grigoriadis K., Dietzen M., Biswas D., Athanasopoulou F., Ward S., Demeulemeester J., Castignani C., Cadieux E. L., Kisistok J., Sokac M., Szallasi Z., Diossy M., Salgado R., Stewart A., Magness A., Weeden C. E., Levi D., Gronroos E., Noorani I., Goldman J., Escudero M., Hobson P., Vendramin R., Boeing S., Denner T., Barbe V., Lu W. -T., Hill W., Naito Y., Ramsden Z., Kassiotis G., Dwornik A., Karamani A., Chain B., Pearce D. R., Karagianni D., Galvez-Cancino F., Stavrou G., Mastrokalos G., Lowe H. L., Matos I. G., Reading J. L., Hartley J. A., Selvaraju K., Chen K., Ensell L., Shah M., Litovchenko M., Chervova O., Pawlik P., Hynds R. E., Gamble S., Ung S. K. A., Bola S. K., Spanswick V., Wu Y., Al-Sawaf O., Jones T. P., Beck S., Tanic M., Marafioti T., Borg E., Falzon M., Khiroya R., Toncheva A., Abbosh C., Richard C., Naceur-Lombardelli C., Gimeno-Valiente F., Thakkar K., Sunderland M. W., Sivakumar M., Kanu N., Prymas P., Saghafinia S., Vanloo S., Lam J. M., Liu W. K., Bunkum A., Hessey S., Zaccaria S., Martinez-Ruiz C., Black J. R. M., Thol K., Bentham R., Litchfield K., McGranahan N., Quezada S. A., Forster M. D., Lee S. M., Herrero J., Nye E., Stone R. K., Nicod J., Rane J. K., Peggs K. S., Ng K. W., Dijkstra K., Huska M. R., Hoogenboom E. M., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Gorman P., Stephens R. C. M., Wong Y. N. S., Kaplar Z., Bandula S., Watkins T. B. K., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Swanton C., Yuan Y., and Moore D. A.
Abstract: The introduction of the International Association for the Study of Lung Cancer grading system has furthered interest in histopathological grading for risk stratification in lung adenocarcinoma. Complex morphology and high intratumoral heterogeneity present challenges to pathologists, prompting the development of artificial intelligence (AI) methods. Here we developed ANORAK (pyrAmid pooliNg crOss stReam Attention networK), encoding multiresolution inputs with an attention mechanism, to delineate growth patterns from hematoxylin and eosin-stained slides. In 1,372 lung adenocarcinomas across four independent cohorts, AI-based grading was prognostic of disease-free survival, and further assisted pathologists by consistently improving prognostication in stage I tumors. Tumors with discrepant patterns between AI and pathologists had notably higher intratumoral heterogeneity. Furthermore, ANORAK facilitates the morphological and spatial assessment of the acinar pattern, capturing acinus variations with pattern transition. Collectively, our AI method enabled the precision quantification and morphology investigation of growth patterns, reflecting intratumoral histological transitions in lung adenocarcinoma.
Published: 2024

6. Low-Mass Dark Matter Search with the DarkSide-50 Experiment

Author: The DarkSide Collaboration, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Araujo, G. R., Asner, D. M., Ave, M., Back, H. O., Baldin, B., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bottino, B., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Cereseto, R., Chepurnov, A., Cicalò, C., Cifarelli, L., Cocco, A. G., Covone, G., D'Angelo, D., D'Incecco, M., D'Urso, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., De Vincenzi, M., Demontis, P., Derbin, A. V., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Downing, M., Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Gabrieli, A., Galbiati, C., Abia, P. Garcia, Ghiano, C., Giagu, S., Giganti, C., Giovanetti, G. K., Gorchakov, O., Goretti, A. M., Granato, F., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B. R., Hassanshahi, M. H., Herner, K., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, Al., Ianni, An., Ippolito, V., James, I., Johnson, T. N., Kahn, Y., Keeter, K., Kendziora, C. L., Kochanek, I., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lisanti, M., Lissia, M., Loer, B., Longo, G., Ma, Y., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Mari, S. M., Maricic, J., Martoff, C. J., Messina, A., Meyers, P. D., Milincic, R., Mishra-Sharma, S., Monte, A., Morrocchi, M., Mount, B. J., Muratova, V. N., Musico, P., Nania, R., Agasson, A. Navrer, Nozdrina, A. O., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pazzona, F., Pelczar, K., Pelliccia, N., Pesudo, V., Pocar, A., Pordes, S., Poudel, S. S., Pugachev, D. A., Qian, H., Ragusa, F., Razeti, M., Razeto, A., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Sant, M., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Segreto, E., Semenov, D. A., Shchagin, A., Sheshukov, A., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Stracka, S., Suffritti, G. B., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Waldrop, T. J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Wojcik, M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., Zichichi, A., and Zuzel, G.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: We present the results of a search for dark matter WIMPs in the mass range below 20 GeV/c^2 using a target of low-radioactivity argon. The data were obtained using the DarkSide-50 apparatus at Laboratori Nazionali del Gran Sasso (LNGS). The analysis is based on the ionization signal, for which the DarkSide-50 time projection chamber is fully efficient at 0.1 keVee. The observed rate in the detector at 0.5 keVee is about 1.5 events/keVee/kg/day and is almost entirely accounted for by known background sources. We obtain a 90% C.L. exclusion limit above 1.8 GeV/c^2 for the spin-independent cross section of dark matter WIMPs on nucleons, extending the exclusion region for dark matter below previous limits in the range 1.8-6 GeV/c^2., Comment: 9 pages, 8 figures; submission accepted by journal
Published: 2018
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7. DarkSide-50 532-day Dark Matter Search with Low-Radioactivity Argon

Author: The DarkSide Collaboration, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Araujo, G. R., Ave, M., Back, H. O., Baldin, B., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bottino, B., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Chepurnov, A., Cicalò, C., Cocco, A. G., Covone, G., D'Angelo, D., D'Incecco, M., D'Urso, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., De Vincenzi, M., Derbin, A. V., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Downing, M., Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fitzpatrick, R. S., Fomenko, K., Franco, D., Gabriele, F., Galbiati, C., Ghiano, C., Giagu, S., Giganti, C., Giovanetti, G. K., Gorchakov, O., Goretti, A. M., Granato, F., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B. R., Herner, K., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, An., Ippolito, V., James, I., Johnson, T. N., Keeter, K., Kendziora, C. L., Kochanek, I., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Ma, Y., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Mari, S. M., Maricic, J., Martoff, C. J., Messina, A., Meyers, P. D., Milincic, R., Monte, A., Morrocchi, M., Mount, B. J., Muratova, V. N., Musico, P., Agasson, A. Navrer, Nozdrina, A. O., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Pocar, A., Pordes, S., Poudel, S. S., Pugachev, D. A., Qian, H., Ragusa, F., Razeti, M., Razeto, A., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Savarese, C., Schlitzer, B., Segreto, E., Semenov, D. A., Shchagin, A., Sheshukov, A., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Waldrop, T. J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., and Zuzel, G.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The DarkSide-50 direct-detection dark matter experiment is a dual-phase argon time projection chamber operating at Laboratori Nazionali del Gran Sasso. This paper reports on the blind analysis of a (16,660+-270) kg d exposure using a target of low-radioactivity argon extracted from underground sources. We find no events in the dark matter selection box and set a 90% C.L. upper limit on the dark matter-nucleon spin-independent cross section of 1.14E-44 cm^2 (3.78E-44 cm^2, 3.43E-43 cm^2) for a WIMP mass of 100 GeV/c^2 (1 TeV/c^2, 10 TeV/c^2)., Comment: 17 pages, 13 figures. V3 changes: updates for clarity for publication, additional figure
Published: 2018
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8. Constraints on Sub-GeV Dark Matter-Electron Scattering from the DarkSide-50 Experiment

Author: The DarkSide Collaboration, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Araujo, G. R., Asner, D. M., Ave, M., Back, H. O., Baldin, B., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bottino, B., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Cereseto, R., Chepurnov, A., Cicalò, C., Cifarelli, L., Cocco, A. G., Covone, G., D'Angelo, D., D'Incecco, M., D'Urso, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., De Vincenzi, M., Demontis, P., Derbin, A. V., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Downing, M., Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Gabrieli, A., Galbiati, C., Abia, P. Garcia, Ghiano, C., Giagu, S., Giganti, C., Giovanetti, G. K., Gorchakov, O., Goretti, A. M., Granato, F., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B. R., Hassanshahi, M. H., Herner, K., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, Al., Ianni, An., Ippolito, V., James, I., Johnson, T. N., Kahn, Y., Keeter, K., Kendziora, C. L., Kochanek, I., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lisanti, M., Lissia, M., Loer, B., Longo, G., Ma, Y., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Mari, S. M., Maricic, J., Martoff, C. J., Messina, A., Meyers, P. D., Milincic, R., Mishra-Sharma, S., Monte, A., Morrocchi, M., Mount, B. J., Muratova, V. N., Musico, P., Nania, R., Agasson, A. Navrer, Nozdrina, A. O., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pazzona, F., Pelczar, K., Pelliccia, N., Pesudo, V., Picciau, E., Pocar, A., Pordes, S., Poudel, S. S., Pugachev, D. A., Qian, H., Ragusa, F., Razeti, M., Razeto, A., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Sant, M., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Segreto, E., Semenov, D. A., Shchagin, A., Sheshukov, A., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Stracka, S., Suffritti, G. B., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Waldrop, T. J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Wojcik, M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., Zichichi, A., and Zuzel, G.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: We present new constraints on sub-GeV dark matter particles scattering off electrons in argon based on an analysis of ionization signal data from the DarkSide-50 detector., Comment: replaced with published version
Published: 2018
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9. Electroluminescence pulse shape and electron diffusion in liquid argon measured in a dual-phase TPC

Author: Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Asner, D. M., Ave, M. P., Back, H. O., Baldin, B., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bossa, M., Bottino, B., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Chepurnov, A., Cicalo, C., Cocco, A. G., Covone, G., D'Angelo, D., D'Incecco, M., D'Urso, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., De Vincenzi, M., Demontis, P., Derbin, A. V., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Edkins, E., Fan, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Gabrieli, A., Galbiati, C., Giagu, S., Giganti, C., Giovanetti, G. K., Goretti, A. M., Granato, F., Gromov, M., Guan, M., Guardinbcerri, Y., Gulino, M., Hackett, B. R., Herner, K., Hughes, D., Humble, P., Hungerford, E. V., Ianni, An., James, I., Johnson, T. N., Keeter, K., Kendziora, C. L., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., Li, X., Lissia, M., Loer, B., Longo, G., Ma, Y., Machado, A. A., Machulin, I. N., Mandarano, A., Mari, S. M., Maricic, J., Martoff, C. J., Messina, A., Meyers, P. D., Milincic, R., Monte, A., Morrocchi, M., Mount, B. J., Muratova, V. N., Musico, P., Agasson, A. Navrer, Nozdrina, A., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pazzona, F., Pelczar, K., Pelliccia, N., Pocar, A., Pordes, S., Qian, H., Razeti, M., Razeto, A., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Sant, M., Savarese, C., Schlitzer, B., Segreto, E., Semenov, D. A., Sheshukov, A., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Suffritti, G. B., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Waldrop, T. J., Walker, S., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., and Zuzel, G.
Subjects: Physics - Instrumentation and Detectors
Abstract: We report the measurement of the longitudinal diffusion constant in liquid argon with the DarkSide-50 dual-phase time projection chamber. The measurement is performed at drift electric fields of 100 V/cm, 150 V/cm, and 200 V/cm using high statistics $^{39}$Ar decays from atmospheric argon. We derive an expression to describe the pulse shape of the electroluminescence signal (S2) in dual-phase TPCs. The derived S2 pulse shape is fit to events from the uppermost portion of the TPC in order to characterize the radial dependence of the signal. The results are provided as inputs to the measurement of the longitudinal diffusion constant DL, which we find to be (4.12 $\pm$ 0.04) cm$^2$/s for a selection of 140keV electron recoil events in 200V/cm drift field and 2.8kV/cm extraction field. To study the systematics of our measurement we examine datasets of varying event energy, field strength, and detector volume yielding a weighted average value for the diffusion constant of (4.09 $\pm$ 0.09) cm$^2$ /s. The measured longitudinal diffusion constant is observed to have an energy dependence, and within the studied energy range the result is systematically lower than other results in the literature.
Published: 2018
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10. Measurement of the ion fraction and mobility of 218Po produced in 222Rn decays in liquid argon

Author: Agnes, P, Albuquerque, IFM, Alexander, T, Alton, AK, Ave, M, Back, HO, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, WM, Bottino, B, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalò, C, Cocco, AG, Covone, G, D'Angelo, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, Derbin, AV, Devoto, A, Di Eusanio, F, D'Incecco, M, Di Pietro, G, Dionisi, C, Downing, M, D'Urso, D, Edkins, E, Empl, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Galbiati, C, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, GK, Gorchakov, O, Goretti, AM, Granato, F, Grobov, A, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, BR, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, EV, Ianni, A, Ippolito, V, Johnson, TN, Keeter, K, Kendziora, CL, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, La Commara, M, Lai, M, Li, X, Lissia, M, Longo, G, Machado, AA, Machulin, IN, Mandarano, A, Mapelli, L, Mari, SM, Maricic, J, Martoff, CJ, Messina, A, Meyers, PD, Milincic, R, Monte, A, and Morrocchi, M
Subjects: Dark Matter detectors, Noble liquid detectors, Time projection chambers, astro-ph.IM, physics.ins-det, Nuclear & Particles Physics, Physical Sciences, Engineering
Abstract: We report measurements of the charged daughter fraction of 218Po as a result of the 222Rn alpha decay, and the mobility of 218Po+ ions, using radon-polonium coincidences from the 238U chain identified in 532 live-days of DarkSide-50 WIMP-search data. The fraction of 218Po that is charged is found to be 0.37 ± 0.03 and the mobility of 218Po+ is (8.6 ± 0.1) × 10−4 cmVs2.
Published: 2019

11. The Electronics, Trigger and Data Acquisition System for the Liquid Argon Time Projection Chamber of the DarkSide-50 Search for Dark Matter

Author: DarkSide Collaboration, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Arisaka, K., Asner, D. M., Ave, M., Back, H. O., Baldin, B., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bossa, M., Bottino, B., Brigatti, A., Brodsky, J., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Canci, N., Candela, A., Cao, H., Caravati, M., Cariello, M., Carlini, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Chepurnov, A., Cicaló, C., Cocco, A. G., Covone, G., Crippa, L., D'Angelo, D., D'Incecco, M., Davini, S., deCandia, A., DeCecco, S., DeDeo, M., DeFilippis, G., DeRosa, G., DeVincenzi, M., Derbin, A., Devoto, A., DiEusanio, F., Dionisi, C., DiPietro, G., Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fomenko, K., Forster, G., Franco, D., Gabriele, F., Galbiat, C., Giagu, S., Giganti, C., Giovanetti, G. K., Goretti, A. M., Granato, F., Grandi, L., Gromov, M., Guan, M., Guardincerri, Y., Hackett, B. R., Herner, K. R., Hughes, D., Humble, P., Hungerford, E. V., Ianni, Aldo, Ianni, Andrea, James, I., Johnson, T. N., Keeter, K., Kendziora, C. L., Kobychev, V., Koh, G., Korablev, D., Korga, G., Kubankin, A., Li, X., Lissia, M., Loer, B., Lombardi, P., Longo, G., Luitz, S., Ma, Y., Machado, A., Machulin, I. N., Mandarano, A., Mari, S. M., Maricic, J., Marini, L., Martoff, C. J., Meyers, P. D., Miletic, T., Milincic, R., Montanari, D., Monte, A., Montuschi, M., Monzani, M. E., Mosteiro, P., Mount, B. J., Muratova, V. N., Musico, P., NavrerAgasson, A., Nelson, A., Odrowsk, S., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pantic, E., Parmeggiano, S., Pelczar, K., Pelliccia, N., Pocar, A., Pordes, S., Pugachev, D. A., Qian, H., Randle, K., Ranucci, G., Razeti, M., Razeto, A., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Rountree, S. D., Sablone, D., Saggese, P., Saldanha, R., Sands, W., Sangiorgio, S., Savarese, C., Schlitzer, B., Segreto, E., Semenov, D. A., Shields, E., Singh, P. N., Skorokhvatov, M. D., Smirno, O., Sotnikov, A., Stanford, C., Suvorov, Y., Tartaglia, R., Tatarowicz, J., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, R. B., Wada, M., Walker, S., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Xiang, X., Xiao, X., Xu, J., Yang, C., Yoo, J., Zavatarelli, S., Zec, A., Zhong, W., Zhu, C., and Zuzel, G.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The DarkSide-50 experiment at the Laboratori Nazionali del Gran Sasso is a search for dark matter using a dual phase time projection chamber with 50 kg of low radioactivity argon as target. Light signals from interactions in the argon are detected by a system of 38 photo-multiplier tubes (PMTs), 19 above and 19 below the TPC volume inside the argon cryostat. We describe the electronics which processes the signals from the photo-multipliers, the trigger system which identifies events of interest, and the data-acquisition system which records the data for further analysis. The electronics include resistive voltage dividers on the PMTs, custom pre-amplifiers mounted directly on the PMT voltage dividers in the liquid argon, and custom amplifier/discriminators (at room temperature). After amplification, the PMT signals are digitized in CAEN waveform digitizers, and CAEN logic modules are used to construct the trigger, the data acquisition system for the TPC is based on the Fermilab "artdaq" software. The system has been in operation since early 2014., Comment: 24 pages
Published: 2017
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12. DarkSide-20k: A 20 Tonne Two-Phase LAr TPC for Direct Dark Matter Detection at LNGS

Author: Aalseth, C. E., Acerbi, F., Agnes, P., Albuquerque, I. F. M., Alexander, T., Alici, A., Alton, A. K., Antonioli, P., Arcelli, S., Ardito, R., Arnquist, I. J., Asner, D. M., Ave, M., Back, H. O., Olmedo, A. I. Barrado, Batignani, G., Bertoldo, E., Bettarini, S., Bisogni, M. G., Bocci, V., Bondar, A., Bonfini, G., Bonivento, W., Bossa, M., Bottino, B., Boulay, M., Bunker, R., Bussino, S., Buzulutskov, A., Cadeddu, M., Cadoni, M., Caminata, A., Canci, N., Candela, A., Cantini, C., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Castellani, A., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Cereseto, R., Chepurnov, A., Cicalò, C., Cifarelli, L., Citterio, M., Cocco, A. G., Colocci, M., Corgiolu, S., Covone, G., Crivelli, P., D'Antone, I., D'Incecco, M., D'Urso, D., Rolo, M. D. Da Rocha, Daniel, M., Davini, S., de Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Guido, G., De Rosa, G., Dellacasa, G., Della Valle, M., Demontis, P., Derbin, A., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Dolgov, A., Dormia, I., Dussoni, S., Empl, A., Diaz, M. Fernandez, Ferri, A., Filip, C., Fiorillo, G., Fomenko, K., Franco, D., Froudakis, G. E., Gabriele, F., Gabrieli, A., Galbiati, C., Abia, P. Garcia, Gendotti, A., Ghisi, A., Giagu, S., Giampa, P., Gibertoni, G., Giganti, C., Giorgi, M. A., Giovanetti, G. K., Gligan, M. L., Gola, A., Gorchakov, O., Goretti, A. M., Granato, F., Grassi, M., Grate, J. W., Grigoriev, G. Y., Gromov, M., Guan, M., Guerra, M. B. B., Guerzoni, M., Gulino, M., Haaland, R. K., Hallin, A., Harrop, B., Hoppe, E. W., Horikawa, S., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, An., Jillings, C., Johnson, T. N., Keeter, K., Kendziora, C. L., Kim, S., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., Kuźniak, M., Lehnert, B., Li, X., Lissia, M., Lodi, G. U., Loer, B., Longo, G., Loverre, P., Lussana, R., Luzzi, L., Ma, Y., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Marcante, M., Margotti, A., Mari, S. M., Mariani, M., Maricic, J., Martoff, C. J., Mascia, M., Mayer, M., McDonald, A. B., Messina, A., Meyers, P. D., Milincic, R., Moggi, A., Moioli, S., Monroe, J., Monte, A., Morrocchi, M., Mount, B. J., Mu, W., Muratova, V. N., Murphy, S., Musico, P., Nania, R., Agasson, A. Navrer, Nikulin, I., Nosov, V., Nozdrina, A. O., Nurakhov, N. N., Oleinik, A., Oleynikov, V., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Palmas, S., Pandola, L., Pantic, E., Paoloni, E., Paternoster, G., Pavletcov, V., Pazzona, F., Peeters, S., Pelczar, K., Pellegrini, L. A., Pelliccia, N., Perotti, F., Perruzza, R., Fortes, V. Pesudo, Piemonte, C., Pilo, F., Pocar, A., Pollmann, T., Portaluppi, D., Pugachev, D. A., Qian, H., Radics, B., Raffaelli, F., Ragusa, F., Razeti, M., Razeto, A., Regazzoni, V., Regenfus, C., Reinhold, B., Renshaw, A. L., Rescigno, M., Retière, F., Riffard, Q., Rivetti, A., Rizzardini, S., Romani, A., Romero, L., Rossi, B., Rossi, N., Rubbia, A., Sablone, D., Salatino, P., Samoylov, O., García, E. Sánchez, Sands, W., Sant, M., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Scioli, G., Segreto, E., Seifert, A., Semenov, D. A., Shchagin, A., Shekhtman, L., Shemyakina, E., Sheshukov, A., Simeone, M., Singh, P. N., Skensved, P., Skorokhvatov, M. D., Smirnov, O., Sobrero, G., Sokolov, A., Sotnikov, A., Speziale, F., Stainforth, R., Stanford, C., Suffritti, G. B., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Tosi, A., Trinchese, P., Unzhakov, E. V., Vacca, A., Vázquez-Jáuregui, E., Verducci, M., Viant, T., Villa, F., Vishneva, A., Vogelaar, B., Wada, M., Wahl, J., Walding, J., Walker, S., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Williams, R., Wojcik, M. M., Wu, S., Xiang, X., Xiao, X., Yang, C., Ye, Z., de Llano, A. Yllera, Zappa, F., Zappalà, G., Zhu, C., Zichichi, A., Zullo, M., and Zullo, A.
Subjects: Physics - Instrumentation and Detectors
Abstract: Building on the successful experience in operating the DarkSide-50 detector, the DarkSide Collaboration is going to construct DarkSide-20k, a direct WIMP search detector using a two-phase Liquid Argon Time Projection Chamber (LArTPC) with an active (fiducial) mass of 23 t (20 t). The DarkSide-20k LArTPC will be deployed within a shield/veto with a spherical Liquid Scintillator Veto (LSV) inside a cylindrical Water Cherenkov Veto (WCV). Operation of DarkSide-50 demonstrated a major reduction in the dominant $^{39}$Ar background when using argon extracted from an underground source, before applying pulse shape analysis. Data from DarkSide-50, in combination with MC simulation and analytical modeling, shows that a rejection factor for discrimination between electron and nuclear recoils of $\gt3\times10^9$ is achievable. This, along with the use of the veto system, is the key to unlocking the path to large LArTPC detector masses, while maintaining an "instrumental background-free" experiment, an experiment in which less than 0.1 events (other than $\nu$-induced nuclear recoils) is expected to occur within the WIMP search region during the planned exposure. DarkSide-20k will have ultra-low backgrounds than can be measured in situ. This will give sensitivity to WIMP-nucleon cross sections of $1.2\times10^{-47}$ cm$^2$ ($1.1\times10^{-46}$ cm$^2$) for WIMPs of $1$ TeV$/c^2$ ($10$ TeV$/c^2$) mass, to be achieved during a 5 yr run producing an exposure of 100 t yr free from any instrumental background. DarkSide-20k could then extend its operation to a decade, increasing the exposure to 200 t yr, reaching a sensitivity of $7.4\times10^{-48}$ cm$^2$ ($6.9\times10^{-47}$ cm$^2$) for WIMPs of $1$ TeV$/c^2$ ($10$ TeV$/c^2$) mass.
Published: 2017
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13. Simulation of argon response and light detection in the DarkSide-50 dual phase TPC

Author: The DarkSide Collaboration, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Asner, D. M., Back, H. O., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bossa, M., Bottino, B., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Chepurnov, A., Cicalo, C., Cocco, A. G., Covone, G., D'Angelo, D., D'Incecco, M., Davini, S., de Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Vincenzi, M., Derbin, A. V., De Rosa, G., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Galbiati, C., Giagu, S., Giganti, C., Giovanetti, G. K., Goretti, A. M., Granato, F., Gromov, M., Guan, M., Guardincerri, Y., Hackett, B. R., Herner, K., Hughes, D., Humble, P., Hungerford, E. V., Ianni, An., James, I., Johnson, T. N., Keeter, K., Kendziora, C. L., Koh, G., Korablev, D., Korga, G., Kubankin, A., Li, X., Lissia, M., Loer, B., Longo, G., Ma, Y., Machado, A. A., Machulin, I. N., Mandarano, A., Mari, S. M., Maricic, J., Martoff, C. J., Meyers, P. D., Milincic, R., Monte, A., Mount, B. J., Muratova, V. N., Musico, P., Napolitano, J., Agasson, A. Navrer, Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pantic, E., Pelczar, K., Pelliccia, N., Pocar, A., Pordes, S., Pugachev, D. A., Qian, H., Randle, K., Razeti, M., Razeto, A., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Sands, W., Sanfilippo, S., Savarese, C., Schlitzer, B., Segreto, E., Semenov, D. A., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Walker, S., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wilhelmi, J., Wojcik, M. M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., and Zuzel, G.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: A Geant4-based Monte Carlo package named G4DS has been developed to simulate the response of DarkSide-50, an experiment operating since 2013 at LNGS, designed to detect WIMP interactions in liquid argon. In the process of WIMP searches, DarkSide-50 has achieved two fundamental milestones: the rejection of electron recoil background with a power of ~10^7, using the pulse shape discrimination technique, and the measurement of the residual 39Ar contamination in underground argon, ~3 orders of magnitude lower with respect to atmospheric argon. These results rely on the accurate simulation of the detector response to the liquid argon scintillation, its ionization, and electron-ion recombination processes. This work provides a complete overview of the DarkSide Monte Carlo and of its performance, with a particular focus on PARIS, the custom-made liquid argon response model., Comment: 29 pages, 23 figures, 1 table
Published: 2017
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14. Cryogenic Characterization of FBK RGB-HD SiPMs

Author: Aalseth, C. E., Acerbi, F., Agnes, P., Albuquerque, I. F. M., Alexander, T., Alici, A., Alton, A. K., Ampudia, P., Antonioli, P., Arcelli, S., Ardito, R., Arnquist, I. J., Asner, D. M., Back, H. O., Batignani, G., Bertoldo, E., Bettarini, S., Bisogni, M. G., Bocci, V., Bondar, A., Bonfini, G., Bonivento, W., Bossa, M., Bottino, B., Bunker, R., Bussino, S., Buzulutskov, A., Cadeddu, M., Cadoni, M., Caminata, A., Canci, N., Candela, A., Cantini, C., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Castellani, A., Catalanotti, S., Cataudella, V., Cavalcante, P., Cereseto, R., Chen, Y., Chepurnov, A., Chiavassa, A., Cicalò, C., Cifarelli, L., Citterio, M., Cocco, A. G., Colocci, M., Corgiolu, S., Covone, G., Crivelli, P., D'Antone, I., D'Incecco, M., Rolo, M. D. Da Rocha, Daniel, M., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Guido, G., De Rosa, G., Dellacasa, G., Demontis, P., Derbin, A. V., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Dolgov, A., Dormia, I., Dussoni, S., Empl, A., Ferri, A., Filip, C., Fiorillo, G., Fomenko, K., Franco, D., Froudakis, G. E., Gabriele, F., Gabrieli, A., Galbiati, C., Abia, P. Garcia, Gendotti, A., Ghisi, A., Giagu, S., Gibertoni, G., Giganti, C., Giorgi, M., Giovanetti, G. K., Gligan, M. L., Gola, A., Gorchakov, O., Goretti, A. M., Granato, F., Grassi, M., Grate, J. W., Grigoriev, G. Y., Gromov, M., Guan, M., Guerra, M. B. B., Guerzoni, M., Gulino, M., Haaland, R. K., Harrop, B., Hoppe, E. W., Horikawa, S., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, An., Cabre, S. Jimenez, Johnson, T. N., Keeter, K., Kendziora, C. L., Kim, S., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kugathasan, R., Kuss, M., Li, X., Lissia, M., Lodi, G. U., Loer, B., Longo, G., Lussana, R., Luzzi, L., Ma, Y., Machado, A. A., Machulin, I. N., Mais, L., Mandarano, A., Mapelli, L., Marcante, M., Margotti, A., Mari, S. M., Mariani, M., Maricic, J., Marinelli, M., Marras, D., Martoff, C. J., Mascia, M., Messina, A., Meyers, P. D., Milincic, R., Moggi, A., Moioli, S., Monasterio, S., Monroe, J., Monte, A., Morrocchi, M., Mu, W., Muratova, V. N., Murphy, S., Musico, P., Nania, R., Napolitano, J., Agasson, A. Navrer, Nikulin, I., Nosov, V., Nozdrina, A. O., Nurakhov, N. N., Oleinik, A., Oleynikov, V., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Palmas, S., Pandola, L., Pantic, E., Paoloni, E., Paternoster, G., Pavletcov, V., Pazzona, F., Pelczar, K., Pellegrini, L. A., Pelliccia, N., Perotti, F., Perruzza, R., Piemonte, C., Pilo, F., Pocar, A., Portaluppi, D., Poudel, S. S., Pugachev, D. A., Qian, H., Radics, B., Raffaelli, F., Ragusa, F., Randle, K., Razeti, M., Razeto, A., Regazzoni, V., Regenfus, C., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Rivetti, A., Romani, A., Romero, L., Rossi, B., Rossi, N., Rubbia, A., Sablone, D., Salatino, P., Samoylov, O., Sands, W., Sant, M., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Scioli, G., Sechi, E., Segreto, E., Seifert, A., Semenov, D. A., Serci, S., Shchagin, A., Shekhtman, L., Shemyakina, E., Sheshukov, A., Simeone, M., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sobrero, G., Sokolov, A., Sotnikov, A., Stanford, C., Suffritti, G. B., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Tosi, A., Trinchese, P., Unzhakov, E. V., Vacca, A., Verducci, M., Viant, T., Villa, F., Vishneva, A., Vogelaar, B., Wada, M., Wahl, J., Walker, S., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wilhelmi, J., Williams, R., Wojcik, M. M., Wu, S., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zappa, F., Zappalà, G., Zhu, C., Zichichi, A., and Zuzel, G.
Subjects: Physics - Instrumentation and Detectors
Abstract: We report on the cryogenic characterization of Red Green Blue - High Density (RGB-HD) SiPMs developed at Fondazione Bruno Kessler (FBK) as part of the DarkSide program of dark matter searches with liquid argon time projection chambers. A dedicated setup was used to measure the primary dark noise, the correlated noise, and the gain of the SiPMs at varying temperatures. A custom-made data acquisition system and analysis software were used to precisely characterize these parameters. We demonstrate that FBK RGB-HD SiPMs with low quenching resistance (RGB-HD-LR$_q$) can be operated from 40 K to 300 K with gains in the range $10^5$ to $10^6$ and noise rates on the order of a few Hz/mm$^2$.
Published: 2017
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15. CALIS - a CALibration Insertion System for the DarkSide-50 dark matter search experiment

Author: Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Asner, D. M., Back, H. O., Baldin, B., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bossa, M., Bottino, B., Brigatti, A., Brodsky, J., Budano, F., Bussino, S., Cadeddu, M., Cadonati, L., Cadoni, M., Calaprice, F., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Catalanotti, S., Cavalcante, P., Chepurnov, A., Cicalo, C., Cocco, A. G., Covone, G., D'Angelo, D., D'Incecco, M., Davini, S., De Cecco, S., De Deo, M., De Vincenzi, M., Derbin, A., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fomenko, K., Forster, G., Franco, D., Gabriele, F., Galbiati, C., Giagu, S., Giganti, C., Giovanetti, G. K., Goretti, A. M., Granato, F., Grandi, L., Gromov, M., Guan, M., Guardincerri, Y., Hackett, B. R., Herner, K., Hughes, D., Humble, P., Hungerford, E. V., Ianni, Al., Ianni, An., James, I., Johnson, T. N., Jollet, C., Keeter, K., Kendziora, C. L., Koh, G., Korablev, D., Korga, G., Kubankin, A., Li, X., Lissia, M., Loer, B., Lombardi, P., Longo, G., Ma, Y., Machulin, I. N., Mandarano, A., Mari, S. M., Maricic, J., Marini, L., Martoff, C. J., Meregaglia, A., Meyers, P. D., Milincic, R., Miller, J. D., Montanari, D., Monte, A., Mount, B. J., Muratova, V. N., Musico, P., Napolitano, J., Agasson, A. Navrer, Odrowski, S., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pantic, E., Parmeggiano, S., Pelczar, K., Pelliccia, N., Pocar, A., Pordes, S., Pugachev, D. A., Qian, H., Randle, K., Ranucci, G., Razeti, M., Razeto, A., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Rountree, D., Sablone, D., Saggese, P., Saldanha, R., Sands, W., Savarese, C., Schlitzer, B., Segreto, E., Semenova, D. A., Shields, E., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Suvorov, Y., Tartaglia, R., Tatarowicz, J., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Walker, S., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wilhelmi, J., Wojcik, M. M., Xiang, Xi., Xiao, X., Xu, J., Yang, C., Zec, A., Zhong, W., Zhu, C., and Zuzel, G.
Subjects: Physics - Instrumentation and Detectors
Abstract: This paper describes the design, fabrication, commissioning and use of a CALibration source Insertion System (CALIS) in the DarkSide-50 direct dark matter search experiment. CALIS deploys radioactive sources into the liquid scintillator veto to characterize the detector response and detection efficiency of the DarkSide-50 Liquid Argon Time Projection Chamber, and the surrounding 30 t organic liquid scintillator neutron veto. It was commissioned in September 2014 and has been used successfully in several gamma and neutron source campaigns since then. A description of the hardware and an excerpt of calibration analysis results are given below., Comment: 21 pages, 11 figures
Published: 2016
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16. Effect of Low Electric Fields on Alpha Scintillation Light Yield in Liquid Argon

Author: Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Asner, D. M., Back, H. O., Baldin, B., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bossa, M., Bottino, B., Brigatti, A., Brodsky, J., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Catalanotti, S., Cavalcante, P., Chepurnov, A., Cicalò, C., Cocco, A. G., Covone, G., D'Angelo, D., D'Incecco, M., Davini, S., De Cecco, S., De Deo, M., De Vincenzi, M., Derbin, A., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fomenko, K., Forster, G., Franco, D., Gabriele, F., Galbiati, C., Giagu, S., Giganti, C., Giovanetti, G. K., Goretti, A. M., Granato, F., Gromov, M., Guan, M., Guardincerri, Y., Hackett, B. R., Herner, K., Hughes, D., Humble, P., Hungerford, E. V., Ianni, A., James, I., Johnson, T. N., Jollet, C., Keeter, K., Kendziora, C. L., Koh, G., Korablev, D., Korga, G., Kubankin, A., Li, X., Lissia, M., Loer, B., Lombardi, P., Longo, G., Ma, Y., Machulin, I. N., Mandarano, A., Mari, S. M., Maricic, J., Marini, L., Martoff, C. J., Meregaglia, A., Meyers, P. D., Milincic, R., Miller, J. D., Montanari, D., Monte, A., Mount, B. J., Muratova, V. N., Musico, P., Napolitano, J., Agasson, A. Navrer, Odrowski, S., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pantic, E., Parmeggiano, S., Pelczar, K., Pelliccia, N., Pocar, A., Pordes, S., Pugachev, D. A., Qian, H., Randle, K., Ranucci, G., Razeti, M., Razeto, A., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Rountree, D., Sablone, D., Saggese, P., Sands, W., Savarese, C., Schlitzer, B., Segreto, E., Semenov, D. A., Shields, E., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Suvorov, Y., Tartaglia, R., Tatarowicz, J., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Walker, S., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wilhelmi, J., Wojcik, M. M., Xiang, X., Xiao, X., Xu, J., Yang, C., Zhong, W., Zhu, C., and Zuzel, G.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: Measurements were made of scintillation light yield of alpha particles from the $^{222}$Rn decay chain within the DarkSide-50 liquid argon time projection chamber. The light yield was found to increase as the applied electric field increased, with alphas in a 200 V/cm electric field exhibiting a 2% increase in light yield compared to alphas in no field., Comment: 5 pages, 5 figures
Published: 2016
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17. The Electronics and Data Acquisition System for the DarkSide-50 Veto Detectors

Author: Agnes, P., Agostino, L., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Arisaka, K., Back, H. O., Baldin, B., Biery, K., Bonfini, G., Bossa, M., Bottino, B., Brigatti, A., Brodsky, J., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Canci, N., Candela, A., Cao, H., Cariello, M., Carlini, M., Catalanotti, S., Cavalcante, P., Chepurnov, A., Cocco, A. G., Covone, G., Crippa, L., D'Angelo, D., D'Incecco, M., Davini, S., De Cecco, S., De Deo, M., De Vincenzi, M., Derbin, A., Devoto, A., Di Eusanio, F., Di Pietro, G., Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fomenko, K., Foster, G., Franco, D., Gabriele, F., Galbiati, C., Giganti, C., Goretti, A. M., Granato, F., Grandi, L., Gromov, M., Guan, M., Guardincerri, Y., Hackett, B. R., Herner, K. R., Hungerford, E. V., Ianni, Aldo, Ianni, Andrea, James, I., Jollet, C., Keeter, K., Kendziora, C. L., Kobychev, V., Koh, G., Korablev, D., Korga, G., Kubankin, A., Li, X., Lissia, M., Lombardi, P., Luitz, S., Ma, Y., Machulin, I. N., Mandarano, A., Mari, S. M., Maricic, J., Marini, L., Martoff, C. J., Meregaglia, A., Meyers, P. D., Miletic, T., Milincic, R., Montanari, D., Monte, A., Montuschi, M., Monzani, M. E., Mosteiro, P., Mount, B. J., Muratova, V. N., Musico, P., Napolitano, J., Nelson, A., Odrowski, S., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pantic, E., Parmeggiano, S., Pelczar, K., Pelliccia, N., Pocar, A., Pordes, S., Pugachev, D. A., Qian, H., Randle, K., Ranucci, G., Razeto, A., Reinhold, B., Renshaw, A. L., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Rountree, S. D., Sablone, D., Saggese, P., Saldanha, R., Sands, W., Sangiorgio, S., Savarese, C., Segreto, E., Semenov, D. A., Shields, E., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Suvorov, Y., Tartaglia, R., Tatarowicz, J., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Vishneva, A., Vogelaar, R. B., Wada, M., Walker, S., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wilhelmi, J., Wojcik, M. M., Xiang, X., Xu, J., Yang, C., Yoo, J., Zavatarelli, S., Zec, A., Zhong, W., Zhu, C., and Zuzel, G.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: DarkSide-50 is a detector for dark matter candidates in the form of weakly interacting massive particles (WIMPs). It utilizes a liquid argon time projection chamber (LAr TPC) for the inner main detector. The TPC is surrounded by a liquid scintillator veto (LSV) and a water Cherenkov veto detector (WCV). The LSV and WCV, both instrumented with PMTs, act as the neutron and cosmogenic muon veto detectors for DarkSide-50. This paper describes the electronics and data acquisition system used for these two detectors.
Published: 2016
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18. The veto system of the DarkSide-50 experiment

Author: The DarkSide Collaboration, Agnes, P., Agostino, L., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Arisaka, K., Back, H. O., Baldin, B., Biery, K., Bonfini, G., Bossa, M., Bottino, B., Brigatti, A., Brodsky, J., Budano, F., Bussino, S., Cadeddu, M., Cadonati, L., Cadoni, M., Calaprice, F., Canci, N., Candela, A., Cao, H., Cariello, M., Carlini, M., Catalanotti, S., Cavalcante, P., Chepurnov, A., Cocco, A. G., Covone, G., Crippa, L., D'Angelo, D., D'Incecco, M., Davini, S., De Cecco, S., De Deo, M., De Vincenzi, M., Derbin, A., Devoto, A., Di Eusanio, F., Di Pietro, G., Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fomenko, K., Foster, G., Franco, D., Gabriele, F., Galbiati, C., Giganti, C., Goretti, A. M., Granato, F., Grandi, L., Gromov, M., Guan, M., Guardincerri, Y., Hackett, B. R., Herner, K. R., Hungerford, E. V., Ianni, Aldo, Ianni, Andrea, James, I., Johnson, T., Jollet, C., Keeter, K., Kendziora, C. L., Kobychev, V., Koh, G., Korablev, D., Korga, G., Kubankin, A., Li, X., Lissia, M., Lombardi, P., Luitz, S., Ma, Y., Machulin, I. N., Mandarano, A., Mari, S. M., Maricic, J., Marini, L., Martoff, C. J., Meregaglia, A., Meyers, P. D., Miletic, T., Milincic, R., Montanari, D., Monte, A., Montuschi, M., Monzani, M. E., Mosteiro, P., Mount, B. J., Muratova, V. N., Musico, P., Napolitano, J., Nelson, A., Odrowski, S., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pantic, E., Parmeggiano, S., Pelczar, K., Pelliccia, N., Perasso, S., Pocar, A., Pordes, S., Pugachev, D. A., Qian, H., Randle, K., Ranucci, G., Razeto, A., Reinhold, B., Renshaw, A. L., Romani, A., Rossi, B., Rossi, N., Rountree, S. D., Sablone, D., Saggese, P., Saldanha, R., Sands, W., Sangiorgio, S., Savarese, C., Segreto, E., Semenov, D. A., Shields, E., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Suvorov, Y., Tartaglia, R., Tatarowicz, J., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Vishneva, A., Vogelaar, B., Wada, M., Walker, S., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wilhelmi, J., Wojcik, M. M., Xiang, X., Xu, J., Yang, C., Yoo, J., Zavatarelli, S., Zec, A., Zhong, W., Zhu, C., and Zuzel, G.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Nuclear recoil events produced by neutron scatters form one of the most important classes of background in WIMP direct detection experiments, as they may produce nuclear recoils that look exactly like WIMP interactions. In DarkSide-50, we both actively suppress and measure the rate of neutron-induced background events using our neutron veto, composed of a boron-loaded liquid scintillator detector within a water Cherenkov detector. This paper is devoted to the description of the neutron veto system of DarkSide-50, including the detector structure, the fundamentals of event reconstruction and data analysis, and basic performance parameters.
Published: 2015
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19. Results from the first use of low radioactivity argon in a dark matter search

Author: The DarkSide Collaboration, Agnes, P., Agostino, L., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Arisaka, K., Back, H. O., Baldin, B., Biery, K., Bonfini, G., Bossa, M., Bottino, B., Brigatti, A., Brodsky, J., Budano, F., Bussino, S., Cadeddu, M., Cadonati, L., Cadoni, M., Calaprice, F., Canci, N., Candela, A., Cao, H., Cariello, M., Carlini, M., Catalanotti, S., Cavalcante, P., Chepurnov, A., Cocco, A. G., Covone, G., Crippa, L., D'Angelo, D., D'Incecco, M., Davini, S., De Cecco, S., De Deo, M., De Vincenzi, M., Derbin, A., Devoto, A., Di Eusanio, F., Di Pietro, G., Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fomenko, K., Forster, G., Franco, D., Gabriele, F., Galbiati, C., Giganti, C., Goretti, A. M., Granato, F., Grandi, L., Gromov, M., Guan, M., Guardincerri, Y., Hackett, B. R., Herner, K., Hungerford, E. V., Ianni, Al., Ianni, An., James, I., Jollet, C., Keeter, K., Kendziora, C. L., Kobychev, V., Koh, G., Korablev, D., Korga, G., Kubankin, A., Li, X., Lissia, M., Lombardi, P., Luitz, S., Ma, Y., Machulin, I. N., Mandarano, A., Mari, S. M., Maricic, J., Marini, L., Martoff, C. J., Meregaglia, A., Meyers, P. D., Miletic, T., Milincic, R., Montanari, D., Monte, A., Montuschi, M., Monzani, M., Mosteiro, P., Mount, B. J., Muratova, V. N., Musico, P., Napolitano, J., Nelson, A., Odrowski, S., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pantic, E., Parmeggiano, S., Pelczar, K., Pelliccia, N., Perasso, S., Pocar, A., Pordes, S., Pugachev, D. A., Qian, H., Randle, K., Ranucci, G., Razeto, A., Reinhold, B., Renshaw, A. L., Romani, A., Rossi, B., Rossi, N., Rountree, D., Sablone, D., Saggese, P., Saldanha, R., Sands, W., Sangiorgio, S., Savarese, C., Segreto, E., Semenov, D. A., Shields, E., Singh, P. N., Skorokhvatov, M. D., Smallcomb, M., Smirnov, O., Sotnikov, A., Stanford, C., Suvorov, Y., Tartaglia, R., Tatarowicz, J., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Vishneva, A., Vogelaar, B., Wada, M., Walker, S., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wilhelmi, J., Wojcik, M. M., Xiang, X., Xu, J., Yang, C., Yoo, J., Zavatarelli, S., Zec, A., Zhong, W., Zhu, C., and Zuzel, G.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: Liquid argon is a bright scintillator with potent particle identification properties, making it an attractive target for direct-detection dark matter searches. The DarkSide-50 dark matter search here reports the first WIMP search results obtained using a target of low-radioactivity argon. DarkSide-50 is a dark matter detector, using two-phase liquid argon time projection chamber, located at the Laboratori Nazionali del Gran Sasso. The underground argon is shown to contain Ar-39 at a level reduced by a factor (1.4 +- 0.2) x 10^3 relative to atmospheric argon. We report a background-free null result from (2616 +- 43) kg d of data, accumulated over 70.9 live-days. When combined with our previous search using an atmospheric argon, the 90 % C.L. upper limit on the WIMP-nucleon spin-independent cross section based on zero events found in the WIMP search regions, is 2.0 x 10^-44 cm^2 (8.6 x 10^-44 cm^2, 8.0 x 10^-43 cm^2) for a WIMP mass of 100 GeV/c^2 (1 TeV/c^2 , 10 TeV/c^2)., Comment: Accepted by Phys. Rev. D
Published: 2015
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20. Body composition and lung cancer-associated cachexia in TRACERx

Author: Al-Sawaf, O, Weiss, J, Skrzypski, M, Lam, J, Karasaki, T, Zambrana, F, Kidd, A, Frankell, A, Watkins, T, Martinez-Ruiz, C, Puttick, C, Black, J, Huebner, A, Bakir, M, Sokac, M, Collins, S, Veeriah, S, Magno, N, Naceur-Lombardelli, C, Prymas, P, Toncheva, A, Ward, S, Jayanth, N, Salgado, R, Bridge, C, Christiani, D, Mak, R, Bay, C, Rosenthal, M, Sattar, N, Welsh, P, Liu, Y, Perrimon, N, Popuri, K, Beg, M, Mcgranahan, N, Hackshaw, A, Breen, D, O'Rahilly, S, Birkbak, N, Aerts, H, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Ang, K, Tufail, M, Chowdhry, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Fennell, D, Matharu, G, Shaw, J, Riley, J, Primrose, L, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, Gilbert, K, Naidu, B, Patel, A, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totten, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Doran, H, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Gomes, F, Brown, K, Carter, M, Chaturvedi, A, Priest, L, Oliveira, P, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Kilgour, E, Dive, C, Schwarz, R, Kaufmann, T, Wilson, G, Rosenthal, R, Van Loo, P, Szallasi, Z, Kisistok, J, Diossy, M, Demeulemeester, J, Bunkum, A, Stewart, A, Magness, A, Rowan, A, Karamani, A, Chain, B, Campbell, B, Castignani, C, Bailey, C, Abbosh, C, Weeden, C, Lee, C, Richard, C, Hiley, C, Moore, D, Pearce, D, Karagianni, D, Biswas, D, Levi, D, Hoxha, E, Cadieux, E, Lim, E, Colliver, E, Nye, E, Gronroos, E, Galvez-Cancino, F, Athanasopoulou, F, Gimeno-Valiente, F, Kassiotis, G, Stavrou, G, Mastrokalos, G, Zhai, H, Lowe, H, Matos, I, Goldman, J, Reading, J, Herrero, J, Rane, J, Nicod, J, Hartley, J, Peggs, K, Enfield, K, Selvaraju, K, Thol, K, Litchfield, K, Ng, K, Chen, K, Dijkstra, K, Grigoriadis, K, Thakkar, K, Ensell, L, Shah, M, Duran, M, Litovchenko, M, Sunderland, M, Hill, M, Dietzen, M, Leung, M, Escudero, M, Angelova, M, Tanic, M, Sivakumar, M, Kanu, N, Chervova, O, Lucas, O, Pich, O, Hobson, P, Pawlik, P, Stone, R, Bentham, R, Hynds, R, Vendramin, R, Saghafinia, S, Lopez, S, Gamble, S, Ung, S, Quezada, S, Vanloo, S, Zaccaria, S, Hessey, S, Boeing, S, Beck, S, Bola, S, Denner, T, Marafioti, T, Mourikis, T, Spanswick, V, Barbe, V, Lu, W, Hill, W, Liu, W, Wu, Y, Naito, Y, Ramsden, Z, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Clark, T, Forster, M, Lee, S, Borg, E, Falzon, M, Papadatos-Pastos, D, Wilson, J, Ahmad, T, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Janes, S, Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Hayward, M, Panagiotopoulos, N, Gorman, P, Khiroya, R, Stephens, R, Wong, Y, Bandula, S, Sharp, A, Smith, S, Gower, N, Dhanda, H, Chan, K, Pilotti, C, Leslie, R, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Yuan, Y, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Cave, J, Scarlett, L, Richards, J, Ingram, P, Austin, S, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Nicholson, A, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Dick, C, Le Quesne, J, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Jamal-Hanjani, M, Swanton, C, Al-Sawaf O., Weiss J., Skrzypski M., Lam J. M., Karasaki T., Zambrana F., Kidd A. C., Frankell A. M., Watkins T. B. K., Martinez-Ruiz C., Puttick C., Black J. R. M., Huebner A., Bakir M. A., Sokac M., Collins S., Veeriah S., Magno N., Naceur-Lombardelli C., Prymas P., Toncheva A., Ward S., Jayanth N., Salgado R., Bridge C. P., Christiani D. C., Mak R. H., Bay C., Rosenthal M., Sattar N., Welsh P., Liu Y., Perrimon N., Popuri K., Beg M. F., McGranahan N., Hackshaw A., Breen D. M., O'Rahilly S., Birkbak N. J., Aerts H. J. W. L., Aerts H. J., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Ang K., Tufail M., Chowdhry M. F., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Fennell D. A., Matharu G., Shaw J. A., Riley J., Primrose L., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., Gilbert K., Naidu B., Patel A. J., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totten N., Montero A., Smith E., Fontaine E., Granato F., Doran H., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P., Gomes F., Brown K., Carter M., Chaturvedi A., Priest L., Oliveira P., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Kilgour E., Dive C., Schwarz R. F., Kaufmann T. L., Wilson G. A., Rosenthal R., Van Loo P., Szallasi Z., Kisistok J., Diossy M., Demeulemeester J., Bunkum A., Stewart A., Magness A., Rowan A., Karamani A., Chain B., Campbell B. B., Castignani C., Bailey C., Abbosh C., Weeden C. E., Lee C., Richard C., Hiley C. T., Moore D. A., Pearce D. R., Karagianni D., Biswas D., Levi D., Hoxha E., Cadieux E. L., Lim E. L., Colliver E., Nye E., Gronroos E., Galvez-Cancino F., Athanasopoulou F., Gimeno-Valiente F., Kassiotis G., Stavrou G., Mastrokalos G., Zhai H., Lowe H. L., Matos I. G., Goldman J., Reading J. L., Herrero J., Rane J. K., Nicod J., Hartley J. A., Peggs K. S., Enfield K. S. S., Selvaraju K., Thol K., Litchfield K., Ng K. W., Chen K., Dijkstra K., Grigoriadis K., Thakkar K., Ensell L., Shah M., Duran M. V., Litovchenko M., Sunderland M. W., Hill M. S., Dietzen M., Leung M., Escudero M., Angelova M., Tanic M., Sivakumar M., Kanu N., Chervova O., Lucas O., Pich O., Hobson P., Pawlik P., Stone R. K., Bentham R., Hynds R. E., Vendramin R., Saghafinia S., Lopez S., Gamble S., Ung S. K. A., Quezada S. A., Vanloo S., Zaccaria S., Hessey S., Boeing S., Beck S., Bola S. K., Denner T., Marafioti T., Mourikis T. P., Spanswick V., Barbe V., Lu W. -T., Hill W., Liu W. K., Wu Y., Naito Y., Ramsden Z., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Clark T., Forster M. D., Lee S. M., Borg E., Falzon M., Papadatos-Pastos D., Wilson J., Ahmad T., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Janes S. M., Hoogenboom E. M., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Hayward M., Panagiotopoulos N., Gorman P., Khiroya R., Stephens R. C., Wong Y. N. S., Bandula S., Sharp A., Smith S., Gower N., Dhanda H. K., Chan K., Pilotti C., Leslie R., Grapa A., Zhang H., AbdulJabbar K., Pan X., Yuan Y., Chuter D., MacKenzie M., Chee S., Alzetani A., Cave J., Scarlett L., Richards J., Ingram P., Austin S., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Nicholson A. G., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Dick C., Le Quesne J., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., Jamal-Hanjani M., Swanton C., Al-Sawaf, O, Weiss, J, Skrzypski, M, Lam, J, Karasaki, T, Zambrana, F, Kidd, A, Frankell, A, Watkins, T, Martinez-Ruiz, C, Puttick, C, Black, J, Huebner, A, Bakir, M, Sokac, M, Collins, S, Veeriah, S, Magno, N, Naceur-Lombardelli, C, Prymas, P, Toncheva, A, Ward, S, Jayanth, N, Salgado, R, Bridge, C, Christiani, D, Mak, R, Bay, C, Rosenthal, M, Sattar, N, Welsh, P, Liu, Y, Perrimon, N, Popuri, K, Beg, M, Mcgranahan, N, Hackshaw, A, Breen, D, O'Rahilly, S, Birkbak, N, Aerts, H, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Ang, K, Tufail, M, Chowdhry, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Fennell, D, Matharu, G, Shaw, J, Riley, J, Primrose, L, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, Gilbert, K, Naidu, B, Patel, A, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totten, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Doran, H, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Gomes, F, Brown, K, Carter, M, Chaturvedi, A, Priest, L, Oliveira, P, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Kilgour, E, Dive, C, Schwarz, R, Kaufmann, T, Wilson, G, Rosenthal, R, Van Loo, P, Szallasi, Z, Kisistok, J, Diossy, M, Demeulemeester, J, Bunkum, A, Stewart, A, Magness, A, Rowan, A, Karamani, A, Chain, B, Campbell, B, Castignani, C, Bailey, C, Abbosh, C, Weeden, C, Lee, C, Richard, C, Hiley, C, Moore, D, Pearce, D, Karagianni, D, Biswas, D, Levi, D, Hoxha, E, Cadieux, E, Lim, E, Colliver, E, Nye, E, Gronroos, E, Galvez-Cancino, F, Athanasopoulou, F, Gimeno-Valiente, F, Kassiotis, G, Stavrou, G, Mastrokalos, G, Zhai, H, Lowe, H, Matos, I, Goldman, J, Reading, J, Herrero, J, Rane, J, Nicod, J, Hartley, J, Peggs, K, Enfield, K, Selvaraju, K, Thol, K, Litchfield, K, Ng, K, Chen, K, Dijkstra, K, Grigoriadis, K, Thakkar, K, Ensell, L, Shah, M, Duran, M, Litovchenko, M, Sunderland, M, Hill, M, Dietzen, M, Leung, M, Escudero, M, Angelova, M, Tanic, M, Sivakumar, M, Kanu, N, Chervova, O, Lucas, O, Pich, O, Hobson, P, Pawlik, P, Stone, R, Bentham, R, Hynds, R, Vendramin, R, Saghafinia, S, Lopez, S, Gamble, S, Ung, S, Quezada, S, Vanloo, S, Zaccaria, S, Hessey, S, Boeing, S, Beck, S, Bola, S, Denner, T, Marafioti, T, Mourikis, T, Spanswick, V, Barbe, V, Lu, W, Hill, W, Liu, W, Wu, Y, Naito, Y, Ramsden, Z, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Clark, T, Forster, M, Lee, S, Borg, E, Falzon, M, Papadatos-Pastos, D, Wilson, J, Ahmad, T, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Janes, S, Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Hayward, M, Panagiotopoulos, N, Gorman, P, Khiroya, R, Stephens, R, Wong, Y, Bandula, S, Sharp, A, Smith, S, Gower, N, Dhanda, H, Chan, K, Pilotti, C, Leslie, R, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Yuan, Y, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Cave, J, Scarlett, L, Richards, J, Ingram, P, Austin, S, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Nicholson, A, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Dick, C, Le Quesne, J, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Jamal-Hanjani, M, Swanton, C, Al-Sawaf O., Weiss J., Skrzypski M., Lam J. M., Karasaki T., Zambrana F., Kidd A. C., Frankell A. M., Watkins T. B. K., Martinez-Ruiz C., Puttick C., Black J. R. M., Huebner A., Bakir M. A., Sokac M., Collins S., Veeriah S., Magno N., Naceur-Lombardelli C., Prymas P., Toncheva A., Ward S., Jayanth N., Salgado R., Bridge C. P., Christiani D. C., Mak R. H., Bay C., Rosenthal M., Sattar N., Welsh P., Liu Y., Perrimon N., Popuri K., Beg M. F., McGranahan N., Hackshaw A., Breen D. M., O'Rahilly S., Birkbak N. J., Aerts H. J. W. L., Aerts H. J., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Ang K., Tufail M., Chowdhry M. F., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Fennell D. A., Matharu G., Shaw J. A., Riley J., Primrose L., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., Gilbert K., Naidu B., Patel A. J., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totten N., Montero A., Smith E., Fontaine E., Granato F., Doran H., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P., Gomes F., Brown K., Carter M., Chaturvedi A., Priest L., Oliveira P., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Kilgour E., Dive C., Schwarz R. F., Kaufmann T. L., Wilson G. A., Rosenthal R., Van Loo P., Szallasi Z., Kisistok J., Diossy M., Demeulemeester J., Bunkum A., Stewart A., Magness A., Rowan A., Karamani A., Chain B., Campbell B. B., Castignani C., Bailey C., Abbosh C., Weeden C. E., Lee C., Richard C., Hiley C. T., Moore D. A., Pearce D. R., Karagianni D., Biswas D., Levi D., Hoxha E., Cadieux E. L., Lim E. L., Colliver E., Nye E., Gronroos E., Galvez-Cancino F., Athanasopoulou F., Gimeno-Valiente F., Kassiotis G., Stavrou G., Mastrokalos G., Zhai H., Lowe H. L., Matos I. G., Goldman J., Reading J. L., Herrero J., Rane J. K., Nicod J., Hartley J. A., Peggs K. S., Enfield K. S. S., Selvaraju K., Thol K., Litchfield K., Ng K. W., Chen K., Dijkstra K., Grigoriadis K., Thakkar K., Ensell L., Shah M., Duran M. V., Litovchenko M., Sunderland M. W., Hill M. S., Dietzen M., Leung M., Escudero M., Angelova M., Tanic M., Sivakumar M., Kanu N., Chervova O., Lucas O., Pich O., Hobson P., Pawlik P., Stone R. K., Bentham R., Hynds R. E., Vendramin R., Saghafinia S., Lopez S., Gamble S., Ung S. K. A., Quezada S. A., Vanloo S., Zaccaria S., Hessey S., Boeing S., Beck S., Bola S. K., Denner T., Marafioti T., Mourikis T. P., Spanswick V., Barbe V., Lu W. -T., Hill W., Liu W. K., Wu Y., Naito Y., Ramsden Z., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Clark T., Forster M. D., Lee S. M., Borg E., Falzon M., Papadatos-Pastos D., Wilson J., Ahmad T., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Janes S. M., Hoogenboom E. M., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Hayward M., Panagiotopoulos N., Gorman P., Khiroya R., Stephens R. C., Wong Y. N. S., Bandula S., Sharp A., Smith S., Gower N., Dhanda H. K., Chan K., Pilotti C., Leslie R., Grapa A., Zhang H., AbdulJabbar K., Pan X., Yuan Y., Chuter D., MacKenzie M., Chee S., Alzetani A., Cave J., Scarlett L., Richards J., Ingram P., Austin S., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Nicholson A. G., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Dick C., Le Quesne J., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., Jamal-Hanjani M., and Swanton C.
Abstract: Cancer-associated cachexia (CAC) is a major contributor to morbidity and mortality in individuals with non-small cell lung cancer. Key features of CAC include alterations in body composition and body weight. Here, we explore the association between body composition and body weight with survival and delineate potential biological processes and mediators that contribute to the development of CAC. Computed tomography-based body composition analysis of 651 individuals in the TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy (Rx)) study suggested that individuals in the bottom 20th percentile of the distribution of skeletal muscle or adipose tissue area at the time of lung cancer diagnosis, had significantly shorter lung cancer-specific survival and overall survival. This finding was validated in 420 individuals in the independent Boston Lung Cancer Study. Individuals classified as having developed CAC according to one or more features at relapse encompassing loss of adipose or muscle tissue, or body mass index-adjusted weight loss were found to have distinct tumor genomic and transcriptomic profiles compared with individuals who did not develop such features. Primary non-small cell lung cancers from individuals who developed CAC were characterized by enrichment of inflammatory signaling and epithelial–mesenchymal transitional pathways, and differentially expressed genes upregulated in these tumors included cancer-testis antigen MAGEA6 and matrix metalloproteinases, such as ADAMTS3. In an exploratory proteomic analysis of circulating putative mediators of cachexia performed in a subset of 110 individuals from TRACERx, a significant association between circulating GDF15 and loss of body weight, skeletal muscle and adipose tissue was identified at relapse, supporting the potential therapeutic relevance of targeting GDF15 in the management of CAC.
Published: 2023

21. Evolutionary characterization of lung adenocarcinoma morphology in TRACERx

Author: Karasaki, T, Moore, D, Veeriah, S, Naceur-Lombardelli, C, Toncheva, A, Magno, N, Ward, S, Bakir, M, Watkins, T, Grigoriadis, K, Huebner, A, Hill, M, Frankell, A, Abbosh, C, Puttick, C, Zhai, H, Gimeno-Valiente, F, Saghafinia, S, Kanu, N, Dietzen, M, Pich, O, Lim, E, Martinez-Ruiz, C, Black, J, Biswas, D, Campbell, B, Lee, C, Colliver, E, Enfield, K, Hessey, S, Hiley, C, Zaccaria, S, Litchfield, K, Birkbak, N, Cadieux, E, Demeulemeester, J, Van Loo, P, Adusumilli, P, Tan, K, Cheema, W, Sanchez-Vega, F, Jones, D, Rekhtman, N, Travis, W, Hackshaw, A, Marafioti, T, Salgado, R, Le Quesne, J, Nicholson, A, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Ang, K, Tufail, M, Chowdhry, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Fennell, D, Matharu, G, Shaw, J, Riley, J, Primrose, L, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, Gilbert, K, Naidu, B, Patel, A, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totten, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Doran, H, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Gomes, F, Brown, K, Carter, M, Chaturvedi, A, Priest, L, Oliveira, P, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Kilgour, E, Dive, C, Aerts, H, Schwarz, R, Kaufmann, T, Wilson, G, Rosenthal, R, Szallasi, Z, Kisistok, J, Sokac, M, Diossy, M, Bunkum, A, Stewart, A, Magness, A, Rowan, A, Karamani, A, Chain, B, Castignani, C, Bailey, C, Weeden, C, Richard, C, Pearce, D, Karagianni, D, Levi, D, Hoxha, E, Nye, E, Gronroos, E, Galvez-Cancino, F, Athanasopoulou, F, Kassiotis, G, Stavrou, G, Mastrokalos, G, Lowe, H, Matos, I, Goldman, J, Reading, J, Herrero, J, Rane, J, Nicod, J, Lam, J, Hartley, J, Peggs, K, Selvaraju, K, Thol, K, Ng, K, Chen, K, Dijkstra, K, Thakkar, K, Ensell, L, Shah, M, Duran, M, Litovchenko, M, Sunderland, M, Leung, M, Escudero, M, Angelova, M, Tanic, M, Sivakumar, M, Chervova, O, Lucas, O, Al-Sawaf, O, Prymas, P, Hobson, P, Pawlik, P, Stone, R, Bentham, R, Hynds, R, Vendramin, R, Lopez, S, Gamble, S, Ung, S, Quezada, S, Vanloo, S, Boeing, S, Beck, S, Bola, S, Denner, T, Mourikis, T, Spanswick, V, Barbe, V, Lu, W, Hill, W, Liu, W, Wu, Y, Naito, Y, Ramsden, Z, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Clark, T, Forster, M, Lee, S, Borg, E, Falzon, M, Papadatos-Pastos, D, Wilson, J, Ahmad, T, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Janes, S, Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Hayward, M, Panagiotopoulos, N, Gorman, P, Khiroya, R, Stephens, R, Wong, Y, Bandula, S, Sharp, A, Smith, S, Gower, N, Dhanda, H, Chan, K, Pilotti, C, Leslie, R, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Yuan, Y, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Cave, J, Scarlett, L, Richards, J, Ingram, P, Austin, S, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Dick, C, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Mcgranahan, N, Swanton, C, Jamal-Hanjani, M, Karasaki T., Moore D. A., Veeriah S., Naceur-Lombardelli C., Toncheva A., Magno N., Ward S., Bakir M. A., Watkins T. B. K., Grigoriadis K., Huebner A., Hill M. S., Frankell A. M., Abbosh C., Puttick C., Zhai H., Gimeno-Valiente F., Saghafinia S., Kanu N., Dietzen M., Pich O., Lim E. L., Martinez-Ruiz C., Black J. R. M., Biswas D., Campbell B. B., Lee C., Colliver E., Enfield K. S. S., Hessey S., Hiley C. T., Zaccaria S., Litchfield K., Birkbak N. J., Cadieux E. L., Demeulemeester J., Van Loo P., Adusumilli P. S., Tan K. S., Cheema W., Sanchez-Vega F., Jones D. R., Rekhtman N., Travis W. D., Hackshaw A., Marafioti T., Salgado R., Le Quesne J., Nicholson A. G., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Ang K., Tufail M., Chowdhry M. F., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Fennell D. A., Matharu G., Shaw J. A., Riley J., Primrose L., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., Gilbert K., Naidu B., Patel A. J., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totten N., Montero A., Smith E., Fontaine E., Granato F., Doran H., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P., Gomes F., Brown K., Carter M., Chaturvedi A., Priest L., Oliveira P., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Kilgour E., Dive C., Aerts H. J. W. L., Schwarz R. F., Kaufmann T. L., Wilson G. A., Rosenthal R., Szallasi Z., Kisistok J., Sokac M., Diossy M., Bunkum A., Stewart A., Magness A., Rowan A., Karamani A., Chain B., Castignani C., Bailey C., Weeden C. E., Richard C., Pearce D. R., Karagianni D., Levi D., Hoxha E., Nye E., Gronroos E., Galvez-Cancino F., Athanasopoulou F., Kassiotis G., Stavrou G., Mastrokalos G., Lowe H. L., Matos I. G., Goldman J., Reading J. L., Herrero J., Rane J. K., Nicod J., Lam J. M., Hartley J. A., Peggs K. S., Selvaraju K., Thol K., Ng K. W., Chen K., Dijkstra K., Thakkar K., Ensell L., Shah M., Duran M. V., Litovchenko M., Sunderland M. W., Leung M., Escudero M., Angelova M., Tanic M., Sivakumar M., Chervova O., Lucas O., Al-Sawaf O., Prymas P., Hobson P., Pawlik P., Stone R. K., Bentham R., Hynds R. E., Vendramin R., Lopez S., Gamble S., Ung S. K. A., Quezada S. A., Vanloo S., Boeing S., Beck S., Bola S. K., Denner T., Mourikis T. P., Spanswick V., Barbe V., Lu W. -T., Hill W., Liu W. K., Wu Y., Naito Y., Ramsden Z., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Clark T., Forster M. D., Lee S. M., Borg E., Falzon M., Papadatos-Pastos D., Wilson J., Ahmad T., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Janes S. M., Hoogenboom E. M., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Hayward M., Panagiotopoulos N., Gorman P., Khiroya R., Stephens R. C., Wong Y. N. S., Bandula S., Sharp A., Smith S., Gower N., Dhanda H. K., Chan K., Pilotti C., Leslie R., Grapa A., Zhang H., AbdulJabbar K., Pan X., Yuan Y., Chuter D., MacKenzie M., Chee S., Alzetani A., Cave J., Scarlett L., Richards J., Ingram P., Austin S., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Dick C., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., McGranahan N., Swanton C., Jamal-Hanjani M., Karasaki, T, Moore, D, Veeriah, S, Naceur-Lombardelli, C, Toncheva, A, Magno, N, Ward, S, Bakir, M, Watkins, T, Grigoriadis, K, Huebner, A, Hill, M, Frankell, A, Abbosh, C, Puttick, C, Zhai, H, Gimeno-Valiente, F, Saghafinia, S, Kanu, N, Dietzen, M, Pich, O, Lim, E, Martinez-Ruiz, C, Black, J, Biswas, D, Campbell, B, Lee, C, Colliver, E, Enfield, K, Hessey, S, Hiley, C, Zaccaria, S, Litchfield, K, Birkbak, N, Cadieux, E, Demeulemeester, J, Van Loo, P, Adusumilli, P, Tan, K, Cheema, W, Sanchez-Vega, F, Jones, D, Rekhtman, N, Travis, W, Hackshaw, A, Marafioti, T, Salgado, R, Le Quesne, J, Nicholson, A, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Ang, K, Tufail, M, Chowdhry, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Fennell, D, Matharu, G, Shaw, J, Riley, J, Primrose, L, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, Gilbert, K, Naidu, B, Patel, A, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totten, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Doran, H, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Gomes, F, Brown, K, Carter, M, Chaturvedi, A, Priest, L, Oliveira, P, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Kilgour, E, Dive, C, Aerts, H, Schwarz, R, Kaufmann, T, Wilson, G, Rosenthal, R, Szallasi, Z, Kisistok, J, Sokac, M, Diossy, M, Bunkum, A, Stewart, A, Magness, A, Rowan, A, Karamani, A, Chain, B, Castignani, C, Bailey, C, Weeden, C, Richard, C, Pearce, D, Karagianni, D, Levi, D, Hoxha, E, Nye, E, Gronroos, E, Galvez-Cancino, F, Athanasopoulou, F, Kassiotis, G, Stavrou, G, Mastrokalos, G, Lowe, H, Matos, I, Goldman, J, Reading, J, Herrero, J, Rane, J, Nicod, J, Lam, J, Hartley, J, Peggs, K, Selvaraju, K, Thol, K, Ng, K, Chen, K, Dijkstra, K, Thakkar, K, Ensell, L, Shah, M, Duran, M, Litovchenko, M, Sunderland, M, Leung, M, Escudero, M, Angelova, M, Tanic, M, Sivakumar, M, Chervova, O, Lucas, O, Al-Sawaf, O, Prymas, P, Hobson, P, Pawlik, P, Stone, R, Bentham, R, Hynds, R, Vendramin, R, Lopez, S, Gamble, S, Ung, S, Quezada, S, Vanloo, S, Boeing, S, Beck, S, Bola, S, Denner, T, Mourikis, T, Spanswick, V, Barbe, V, Lu, W, Hill, W, Liu, W, Wu, Y, Naito, Y, Ramsden, Z, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Clark, T, Forster, M, Lee, S, Borg, E, Falzon, M, Papadatos-Pastos, D, Wilson, J, Ahmad, T, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Janes, S, Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Hayward, M, Panagiotopoulos, N, Gorman, P, Khiroya, R, Stephens, R, Wong, Y, Bandula, S, Sharp, A, Smith, S, Gower, N, Dhanda, H, Chan, K, Pilotti, C, Leslie, R, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Yuan, Y, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Cave, J, Scarlett, L, Richards, J, Ingram, P, Austin, S, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Dick, C, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Mcgranahan, N, Swanton, C, Jamal-Hanjani, M, Karasaki T., Moore D. A., Veeriah S., Naceur-Lombardelli C., Toncheva A., Magno N., Ward S., Bakir M. A., Watkins T. B. K., Grigoriadis K., Huebner A., Hill M. S., Frankell A. M., Abbosh C., Puttick C., Zhai H., Gimeno-Valiente F., Saghafinia S., Kanu N., Dietzen M., Pich O., Lim E. L., Martinez-Ruiz C., Black J. R. M., Biswas D., Campbell B. B., Lee C., Colliver E., Enfield K. S. S., Hessey S., Hiley C. T., Zaccaria S., Litchfield K., Birkbak N. J., Cadieux E. L., Demeulemeester J., Van Loo P., Adusumilli P. S., Tan K. S., Cheema W., Sanchez-Vega F., Jones D. R., Rekhtman N., Travis W. D., Hackshaw A., Marafioti T., Salgado R., Le Quesne J., Nicholson A. G., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Ang K., Tufail M., Chowdhry M. F., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Fennell D. A., Matharu G., Shaw J. A., Riley J., Primrose L., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., Gilbert K., Naidu B., Patel A. J., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totten N., Montero A., Smith E., Fontaine E., Granato F., Doran H., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P., Gomes F., Brown K., Carter M., Chaturvedi A., Priest L., Oliveira P., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Kilgour E., Dive C., Aerts H. J. W. L., Schwarz R. F., Kaufmann T. L., Wilson G. A., Rosenthal R., Szallasi Z., Kisistok J., Sokac M., Diossy M., Bunkum A., Stewart A., Magness A., Rowan A., Karamani A., Chain B., Castignani C., Bailey C., Weeden C. E., Richard C., Pearce D. R., Karagianni D., Levi D., Hoxha E., Nye E., Gronroos E., Galvez-Cancino F., Athanasopoulou F., Kassiotis G., Stavrou G., Mastrokalos G., Lowe H. L., Matos I. G., Goldman J., Reading J. L., Herrero J., Rane J. K., Nicod J., Lam J. M., Hartley J. A., Peggs K. S., Selvaraju K., Thol K., Ng K. W., Chen K., Dijkstra K., Thakkar K., Ensell L., Shah M., Duran M. V., Litovchenko M., Sunderland M. W., Leung M., Escudero M., Angelova M., Tanic M., Sivakumar M., Chervova O., Lucas O., Al-Sawaf O., Prymas P., Hobson P., Pawlik P., Stone R. K., Bentham R., Hynds R. E., Vendramin R., Lopez S., Gamble S., Ung S. K. A., Quezada S. A., Vanloo S., Boeing S., Beck S., Bola S. K., Denner T., Mourikis T. P., Spanswick V., Barbe V., Lu W. -T., Hill W., Liu W. K., Wu Y., Naito Y., Ramsden Z., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Clark T., Forster M. D., Lee S. M., Borg E., Falzon M., Papadatos-Pastos D., Wilson J., Ahmad T., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Janes S. M., Hoogenboom E. M., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Hayward M., Panagiotopoulos N., Gorman P., Khiroya R., Stephens R. C., Wong Y. N. S., Bandula S., Sharp A., Smith S., Gower N., Dhanda H. K., Chan K., Pilotti C., Leslie R., Grapa A., Zhang H., AbdulJabbar K., Pan X., Yuan Y., Chuter D., MacKenzie M., Chee S., Alzetani A., Cave J., Scarlett L., Richards J., Ingram P., Austin S., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Dick C., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., McGranahan N., Swanton C., and Jamal-Hanjani M.
Abstract: Lung adenocarcinomas (LUADs) display a broad histological spectrum from low-grade lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform and micropapillary tumors. How morphology reflects tumor evolution and disease progression is poorly understood. Whole-exome sequencing data generated from 805 primary tumor regions and 121 paired metastatic samples across 248 LUADs from the TRACERx 421 cohort, together with RNA-sequencing data from 463 primary tumor regions, were integrated with detailed whole-tumor and regional histopathological analysis. Tumors with predominantly high-grade patterns showed increased chromosomal complexity, with higher burden of loss of heterozygosity and subclonal somatic copy number alterations. Individual regions in predominantly high-grade pattern tumors exhibited higher proliferation and lower clonal diversity, potentially reflecting large recent subclonal expansions. Co-occurrence of truncal loss of chromosomes 3p and 3q was enriched in predominantly low-/mid-grade tumors, while purely undifferentiated solid-pattern tumors had a higher frequency of truncal arm or focal 3q gains and SMARCA4 gene alterations compared with mixed-pattern tumors with a solid component, suggesting distinct evolutionary trajectories. Clonal evolution analysis revealed that tumors tend to evolve toward higher-grade patterns. The presence of micropapillary pattern and ‘tumor spread through air spaces’ were associated with intrathoracic recurrence, in contrast to the presence of solid/cribriform patterns, necrosis and preoperative circulating tumor DNA detection, which were associated with extra-thoracic recurrence. These data provide insights into the relationship between LUAD morphology, the underlying evolutionary genomic landscape, and clinical and anatomical relapse risk.
Published: 2023

22. Genomic–transcriptomic evolution in lung cancer and metastasis

Author: Martinez-Ruiz, C, Black, J, Puttick, C, Hill, M, Demeulemeester, J, Larose Cadieux, E, Thol, K, Jones, T, Veeriah, S, Naceur-Lombardelli, C, Toncheva, A, Prymas, P, Rowan, A, Ward, S, Cubitt, L, Athanasopoulou, F, Pich, O, Karasaki, T, Moore, D, Salgado, R, Colliver, E, Castignani, C, Dietzen, M, Huebner, A, Al Bakir, M, Tanic, M, Watkins, T, Lim, E, Al-Rashed, A, Lang, D, Clements, J, Cook, D, Rosenthal, R, Wilson, G, Frankell, A, de Carne Trecesson, S, East, P, Kanu, N, Litchfield, K, Birkbak, N, Hackshaw, A, Beck, S, Van Loo, P, Jamal-Hanjani, M, Mcgranahan, N, Swanton, C, Bakir, M, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Ang, K, Tufail, M, Chowdhry, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Fennell, D, Matharu, G, Shaw, J, Riley, J, Primrose, L, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, Gilbert, K, Naidu, B, Patel, A, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totten, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Doran, H, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Gomes, F, Brown, K, Carter, M, Chaturvedi, A, Priest, L, Oliveira, P, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Kilgour, E, Dive, C, Aerts, H, Schwarz, R, Kaufmann, T, Szallasi, Z, Kisistok, J, Sokac, M, Diossy, M, Bunkum, A, Stewart, A, Magness, A, Karamani, A, Chain, B, Campbell, B, Bailey, C, Abbosh, C, Weeden, C, Lee, C, Richard, C, Hiley, C, Pearce, D, Karagianni, D, Biswas, D, Levi, D, Hoxha, E, Nye, E, Gronroos, E, Galvez-Cancino, F, Gimeno-Valiente, F, Kassiotis, G, Stavrou, G, Mastrokalos, G, Zhai, H, Lowe, H, Matos, I, Goldman, J, Reading, J, Herrero, J, Rane, J, Nicod, J, Lam, J, Hartley, J, Peggs, K, Enfield, K, Selvaraju, K, Ng, K, Chen, K, Dijkstra, K, Grigoriadis, K, Thakkar, K, Ensell, L, Shah, M, Duran, M, Litovchenko, M, Sunderland, M, Leung, M, Escudero, M, Angelova, M, Sivakumar, M, Chervova, O, Lucas, O, Al-Sawaf, O, Hobson, P, Pawlik, P, Stone, R, Bentham, R, Hynds, R, Vendramin, R, Saghafinia, S, Lopez, S, Gamble, S, Ung, S, Quezada, S, Vanloo, S, Zaccaria, S, Hessey, S, Boeing, S, Bola, S, Denner, T, Marafioti, T, Mourikis, T, Spanswick, V, Barbe, V, Lu, W, Hill, W, Liu, W, Wu, Y, Naito, Y, Ramsden, Z, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Clark, T, Forster, M, Lee, S, Borg, E, Falzon, M, Papadatos-Pastos, D, Wilson, J, Ahmad, T, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Janes, S, Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Hayward, M, Panagiotopoulos, N, Gorman, P, Khiroya, R, Stephens, R, Wong, Y, Bandula, S, Sharp, A, Smith, S, Gower, N, Dhanda, H, Chan, K, Pilotti, C, Leslie, R, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Yuan, Y, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Cave, J, Scarlett, L, Richards, J, Ingram, P, Austin, S, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Nicholson, A, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Dick, C, Le Quesne, J, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Martinez-Ruiz C., Black J. R. M., Puttick C., Hill M. S., Demeulemeester J., Larose Cadieux E., Thol K., Jones T. P., Veeriah S., Naceur-Lombardelli C., Toncheva A., Prymas P., Rowan A., Ward S., Cubitt L., Athanasopoulou F., Pich O., Karasaki T., Moore D. A., Salgado R., Colliver E., Castignani C., Dietzen M., Huebner A., Al Bakir M., Tanic M., Watkins T. B. K., Lim E. L., Al-Rashed A. M., Lang D., Clements J., Cook D. E., Rosenthal R., Wilson G. A., Frankell A. M., de Carne Trecesson S., East P., Kanu N., Litchfield K., Birkbak N. J., Hackshaw A., Beck S., Van Loo P., Jamal-Hanjani M., McGranahan N., Swanton C., Bakir M. A., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Ang K., Tufail M., Chowdhry M. F., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Fennell D. A., Matharu G., Shaw J. A., Riley J., Primrose L., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., Gilbert K., Naidu B., Patel A. J., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totten N., Montero A., Smith E., Fontaine E., Granato F., Doran H., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P., Gomes F., Brown K., Carter M., Chaturvedi A., Priest L., Oliveira P., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Kilgour E., Dive C., Aerts H. J. W. L., Schwarz R. F., Kaufmann T. L., Szallasi Z., Kisistok J., Sokac M., Diossy M., Bunkum A., Stewart A., Magness A., Karamani A., Chain B., Campbell B. B., Bailey C., Abbosh C., Weeden C. E., Lee C., Richard C., Hiley C. T., Pearce D. R., Karagianni D., Biswas D., Levi D., Hoxha E., Nye E., Gronroos E., Galvez-Cancino F., Gimeno-Valiente F., Kassiotis G., Stavrou G., Mastrokalos G., Zhai H., Lowe H. L., Matos I. G., Goldman J., Reading J. L., Herrero J., Rane J. K., Nicod J., Lam J. M., Hartley J. A., Peggs K. S., Enfield K. S. S., Selvaraju K., Ng K. W., Chen K., Dijkstra K., Grigoriadis K., Thakkar K., Ensell L., Shah M., Duran M. V., Litovchenko M., Sunderland M. W., Leung M., Escudero M., Angelova M., Sivakumar M., Chervova O., Lucas O., Al-Sawaf O., Hobson P., Pawlik P., Stone R. K., Bentham R., Hynds R. E., Vendramin R., Saghafinia S., Lopez S., Gamble S., Ung S. K. A., Quezada S. A., Vanloo S., Zaccaria S., Hessey S., Boeing S., Bola S. K., Denner T., Marafioti T., Mourikis T. P., Spanswick V., Barbe V., Lu W. -T., Hill W., Liu W. K., Wu Y., Naito Y., Ramsden Z., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Clark T., Forster M. D., Lee S. M., Borg E., Falzon M., Papadatos-Pastos D., Wilson J., Ahmad T., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Janes S. M., Hoogenboom E. M., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Hayward M., Panagiotopoulos N., Gorman P., Khiroya R., Stephens R. C. M., Wong Y. N. S., Bandula S., Sharp A., Smith S., Gower N., Dhanda H. K., Chan K., Pilotti C., Leslie R., Grapa A., Zhang H., AbdulJabbar K., Pan X., Yuan Y., Chuter D., MacKenzie M., Chee S., Alzetani A., Cave J., Scarlett L., Richards J., Ingram P., Austin S., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Nicholson A. G., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Dick C., Le Quesne J., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., Martinez-Ruiz, C, Black, J, Puttick, C, Hill, M, Demeulemeester, J, Larose Cadieux, E, Thol, K, Jones, T, Veeriah, S, Naceur-Lombardelli, C, Toncheva, A, Prymas, P, Rowan, A, Ward, S, Cubitt, L, Athanasopoulou, F, Pich, O, Karasaki, T, Moore, D, Salgado, R, Colliver, E, Castignani, C, Dietzen, M, Huebner, A, Al Bakir, M, Tanic, M, Watkins, T, Lim, E, Al-Rashed, A, Lang, D, Clements, J, Cook, D, Rosenthal, R, Wilson, G, Frankell, A, de Carne Trecesson, S, East, P, Kanu, N, Litchfield, K, Birkbak, N, Hackshaw, A, Beck, S, Van Loo, P, Jamal-Hanjani, M, Mcgranahan, N, Swanton, C, Bakir, M, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Ang, K, Tufail, M, Chowdhry, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Fennell, D, Matharu, G, Shaw, J, Riley, J, Primrose, L, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, Gilbert, K, Naidu, B, Patel, A, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totten, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Doran, H, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Gomes, F, Brown, K, Carter, M, Chaturvedi, A, Priest, L, Oliveira, P, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Kilgour, E, Dive, C, Aerts, H, Schwarz, R, Kaufmann, T, Szallasi, Z, Kisistok, J, Sokac, M, Diossy, M, Bunkum, A, Stewart, A, Magness, A, Karamani, A, Chain, B, Campbell, B, Bailey, C, Abbosh, C, Weeden, C, Lee, C, Richard, C, Hiley, C, Pearce, D, Karagianni, D, Biswas, D, Levi, D, Hoxha, E, Nye, E, Gronroos, E, Galvez-Cancino, F, Gimeno-Valiente, F, Kassiotis, G, Stavrou, G, Mastrokalos, G, Zhai, H, Lowe, H, Matos, I, Goldman, J, Reading, J, Herrero, J, Rane, J, Nicod, J, Lam, J, Hartley, J, Peggs, K, Enfield, K, Selvaraju, K, Ng, K, Chen, K, Dijkstra, K, Grigoriadis, K, Thakkar, K, Ensell, L, Shah, M, Duran, M, Litovchenko, M, Sunderland, M, Leung, M, Escudero, M, Angelova, M, Sivakumar, M, Chervova, O, Lucas, O, Al-Sawaf, O, Hobson, P, Pawlik, P, Stone, R, Bentham, R, Hynds, R, Vendramin, R, Saghafinia, S, Lopez, S, Gamble, S, Ung, S, Quezada, S, Vanloo, S, Zaccaria, S, Hessey, S, Boeing, S, Bola, S, Denner, T, Marafioti, T, Mourikis, T, Spanswick, V, Barbe, V, Lu, W, Hill, W, Liu, W, Wu, Y, Naito, Y, Ramsden, Z, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Clark, T, Forster, M, Lee, S, Borg, E, Falzon, M, Papadatos-Pastos, D, Wilson, J, Ahmad, T, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Janes, S, Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Hayward, M, Panagiotopoulos, N, Gorman, P, Khiroya, R, Stephens, R, Wong, Y, Bandula, S, Sharp, A, Smith, S, Gower, N, Dhanda, H, Chan, K, Pilotti, C, Leslie, R, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Yuan, Y, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Cave, J, Scarlett, L, Richards, J, Ingram, P, Austin, S, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Nicholson, A, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Dick, C, Le Quesne, J, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Martinez-Ruiz C., Black J. R. M., Puttick C., Hill M. S., Demeulemeester J., Larose Cadieux E., Thol K., Jones T. P., Veeriah S., Naceur-Lombardelli C., Toncheva A., Prymas P., Rowan A., Ward S., Cubitt L., Athanasopoulou F., Pich O., Karasaki T., Moore D. A., Salgado R., Colliver E., Castignani C., Dietzen M., Huebner A., Al Bakir M., Tanic M., Watkins T. B. K., Lim E. L., Al-Rashed A. M., Lang D., Clements J., Cook D. E., Rosenthal R., Wilson G. A., Frankell A. M., de Carne Trecesson S., East P., Kanu N., Litchfield K., Birkbak N. J., Hackshaw A., Beck S., Van Loo P., Jamal-Hanjani M., McGranahan N., Swanton C., Bakir M. A., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Ang K., Tufail M., Chowdhry M. F., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Fennell D. A., Matharu G., Shaw J. A., Riley J., Primrose L., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., Gilbert K., Naidu B., Patel A. J., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totten N., Montero A., Smith E., Fontaine E., Granato F., Doran H., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P., Gomes F., Brown K., Carter M., Chaturvedi A., Priest L., Oliveira P., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Kilgour E., Dive C., Aerts H. J. W. L., Schwarz R. F., Kaufmann T. L., Szallasi Z., Kisistok J., Sokac M., Diossy M., Bunkum A., Stewart A., Magness A., Karamani A., Chain B., Campbell B. B., Bailey C., Abbosh C., Weeden C. E., Lee C., Richard C., Hiley C. T., Pearce D. R., Karagianni D., Biswas D., Levi D., Hoxha E., Nye E., Gronroos E., Galvez-Cancino F., Gimeno-Valiente F., Kassiotis G., Stavrou G., Mastrokalos G., Zhai H., Lowe H. L., Matos I. G., Goldman J., Reading J. L., Herrero J., Rane J. K., Nicod J., Lam J. M., Hartley J. A., Peggs K. S., Enfield K. S. S., Selvaraju K., Ng K. W., Chen K., Dijkstra K., Grigoriadis K., Thakkar K., Ensell L., Shah M., Duran M. V., Litovchenko M., Sunderland M. W., Leung M., Escudero M., Angelova M., Sivakumar M., Chervova O., Lucas O., Al-Sawaf O., Hobson P., Pawlik P., Stone R. K., Bentham R., Hynds R. E., Vendramin R., Saghafinia S., Lopez S., Gamble S., Ung S. K. A., Quezada S. A., Vanloo S., Zaccaria S., Hessey S., Boeing S., Bola S. K., Denner T., Marafioti T., Mourikis T. P., Spanswick V., Barbe V., Lu W. -T., Hill W., Liu W. K., Wu Y., Naito Y., Ramsden Z., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Clark T., Forster M. D., Lee S. M., Borg E., Falzon M., Papadatos-Pastos D., Wilson J., Ahmad T., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Janes S. M., Hoogenboom E. M., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Hayward M., Panagiotopoulos N., Gorman P., Khiroya R., Stephens R. C. M., Wong Y. N. S., Bandula S., Sharp A., Smith S., Gower N., Dhanda H. K., Chan K., Pilotti C., Leslie R., Grapa A., Zhang H., AbdulJabbar K., Pan X., Yuan Y., Chuter D., MacKenzie M., Chee S., Alzetani A., Cave J., Scarlett L., Richards J., Ingram P., Austin S., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Nicholson A. G., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Dick C., Le Quesne J., Kirk A., Asif M., Bilancia R., Kostoulas N., and Thomas M.
Abstract: Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance to therapy1. Here, using paired whole-exome and RNA sequencing data, we investigate intratumour transcriptomic diversity in 354 non-small cell lung cancer tumours from 347 out of the first 421 patients prospectively recruited into the TRACERx study2,3. Analyses of 947 tumour regions, representing both primary and metastatic disease, alongside 96 tumour-adjacent normal tissue samples implicate the transcriptome as a major source of phenotypic variation. Gene expression levels and ITH relate to patterns of positive and negative selection during tumour evolution. We observe frequent copy number-independent allele-specific expression that is linked to epigenomic dysfunction. Allele-specific expression can also result in genomic–transcriptomic parallel evolution, which converges on cancer gene disruption. We extract signatures of RNA single-base substitutions and link their aetiology to the activity of the RNA-editing enzymes ADAR and APOBEC3A, thereby revealing otherwise undetected ongoing APOBEC activity in tumours. Characterizing the transcriptomes of primary–metastatic tumour pairs, we combine multiple machine-learning approaches that leverage genomic and transcriptomic variables to link metastasis-seeding potential to the evolutionary context of mutations and increased proliferation within primary tumour regions. These results highlight the interplay between the genome and transcriptome in influencing ITH, lung cancer evolution and metastasis.
Published: 2023

23. Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA

Author: Abbosh, C, Frankell, A, Harrison, T, Kisistok, J, Garnett, A, Johnson, L, Veeriah, S, Moreau, M, Chesh, A, Chaunzwa, T, Weiss, J, Schroeder, M, Ward, S, Grigoriadis, K, Shahpurwalla, A, Litchfield, K, Puttick, C, Biswas, D, Karasaki, T, Black, J, Martinez-Ruiz, C, Bakir, M, Pich, O, Watkins, T, Lim, E, Huebner, A, Moore, D, Godin-Heymann, N, L'Hernault, A, Bye, H, Odell, A, Roberts, P, Gomes, F, Patel, A, Manzano, E, Hiley, C, Carey, N, Riley, J, Cook, D, Hodgson, D, Stetson, D, Barrett, J, Kortlever, R, Evan, G, Hackshaw, A, Daber, R, Shaw, J, Aerts, H, Licon, A, Stahl, J, Jamal-Hanjani, M, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Ang, K, Tufail, M, Chowdhry, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Fennell, D, Matharu, G, Primrose, L, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, Gilbert, K, Naidu, B, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totten, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Doran, H, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Brown, K, Carter, M, Chaturvedi, A, Priest, L, Oliveira, P, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Kilgour, E, Dive, C, Schwarz, R, Kaufmann, T, Wilson, G, Rosenthal, R, Van Loo, P, Szallasi, Z, Sokac, M, Salgado, R, Diossy, M, Demeulemeester, J, Bunkum, A, Stewart, A, Magness, A, Rowan, A, Karamani, A, Toncheva, A, Chain, B, Campbell, B, Castignani, C, Bailey, C, Weeden, C, Lee, C, Richard, C, Naceur-Lombardelli, C, Pearce, D, Karagianni, D, Levi, D, Hoxha, E, Larose Cadieux, E, Colliver, E, Nye, E, Gronroos, E, Galvez-Cancino, F, Athanasopoulou, F, Gimeno-Valiente, F, Kassiotis, G, Stavrou, G, Mastrokalos, G, Zhai, H, Lowe, H, Matos, I, Goldman, J, Reading, J, Herrero, J, Rane, J, Nicod, J, Lam, J, Hartley, J, Peggs, K, Enfield, K, Selvaraju, K, Thol, K, Ng, K, Chen, K, Dijkstra, K, Thakkar, K, Ensell, L, Shah, M, Vasquez, M, Litovchenko, M, Werner Sunderland, M, Hill, M, Dietzen, M, Leung, M, Escudero, M, Angelova, M, Tanic, M, Sivakumar, M, Kanu, N, Chervova, O, Lucas, O, Al-Sawaf, O, Prymas, P, Hobson, P, Pawlik, P, Stone, R, Bentham, R, Hynds, R, Vendramin, R, Saghafinia, S, Lopez, S, Gamble, S, Ung, S, Quezada, S, Vanloo, S, Zaccaria, S, Hessey, S, Boeing, S, Beck, S, Bola, S, Denner, T, Marafioti, T, Mourikis, T, Spanswick, V, Barbe, V, Lu, W, Hill, W, Liu, W, Wu, Y, Naito, Y, Ramsden, Z, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Clark, T, Forster, M, Lee, S, Borg, E, Falzon, M, Papadatos-Pastos, D, Wilson, J, Ahmad, T, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Janes, S, Martinoni Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Hayward, M, Panagiotopoulos, N, Gorman, P, Khiroya, R, Stephens, R, Wong, Y, Bandula, S, Sharp, A, Smith, S, Gower, N, Dhanda, H, Chan, K, Pilotti, C, Leslie, R, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Yuan, Y, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Cave, J, Scarlett, L, Richards, J, Ingram, P, Austin, S, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Nicholson, A, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Dick, C, Le Quesne, J, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Birkbak, N, Mcgranahan, N, Swanton, C, Abbosh C., Frankell A. M., Harrison T., Kisistok J., Garnett A., Johnson L., Veeriah S., Moreau M., Chesh A., Chaunzwa T. L., Weiss J., Schroeder M. R., Ward S., Grigoriadis K., Shahpurwalla A., Litchfield K., Puttick C., Biswas D., Karasaki T., Black J. R. M., Martinez-Ruiz C., Bakir M. A., Pich O., Watkins T. B. K., Lim E. L., Huebner A., Moore D. A., Godin-Heymann N., L'Hernault A., Bye H., Odell A., Roberts P., Gomes F., Patel A. J., Manzano E., Hiley C. T., Carey N., Riley J., Cook D. E., Hodgson D., Stetson D., Barrett J. C., Kortlever R. M., Evan G. I., Hackshaw A., Daber R. D., Shaw J. A., Aerts H. J. W. L., Licon A., Stahl J., Jamal-Hanjani M., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Ang K., Tufail M., Chowdhry M. F., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Fennell D. A., Matharu G., Primrose L., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., Gilbert K., Naidu B., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totten N., Montero A., Smith E., Fontaine E., Granato F., Doran H., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P., Brown K., Carter M., Chaturvedi A., Priest L., Oliveira P., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Kilgour E., Dive C., Schwarz R. F., Kaufmann T. L., Wilson G. A., Rosenthal R., Van Loo P., Szallasi Z., Sokac M., Salgado R., Diossy M., Demeulemeester J., Bunkum A., Stewart A., Magness A., Rowan A., Karamani A., Toncheva A., Chain B., Campbell B. B., Castignani C., Bailey C., Weeden C. E., Lee C., Richard C., Naceur-Lombardelli C., Pearce D. R., Karagianni D., Levi D., Hoxha E., Larose Cadieux E., Colliver E., Nye E., Gronroos E., Galvez-Cancino F., Athanasopoulou F., Gimeno-Valiente F., Kassiotis G., Stavrou G., Mastrokalos G., Zhai H., Lowe H. L., Matos I., Goldman J., Reading J. L., Herrero J., Rane J. K., Nicod J., Lam J. M., Hartley J. A., Peggs K. S., Enfield K. S. S., Selvaraju K., Thol K., Ng K. W., Chen K., Dijkstra K., Thakkar K., Ensell L., Shah M., Vasquez M., Litovchenko M., Werner Sunderland M., Hill M. S., Dietzen M., Leung M., Escudero M., Angelova M., Tanic M., Sivakumar M., Kanu N., Chervova O., Lucas O., Al-Sawaf O., Prymas P., Hobson P., Pawlik P., Stone R. K., Bentham R., Hynds R. E., Vendramin R., Saghafinia S., Lopez S., Gamble S., Ung S. K. A., Quezada S. A., Vanloo S., Zaccaria S., Hessey S., Boeing S., Beck S., Bola S. K., Denner T., Marafioti T., Mourikis T. P., Spanswick V., Barbe V., Lu W. -T., Hill W., Liu W. K., Wu Y., Naito Y., Ramsden Z., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Clark T., Forster M. D., Lee S. M., Borg E., Falzon M., Papadatos-Pastos D., Wilson J., Ahmad T., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Janes S. M., Martinoni Hoogenboom E., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Hayward M., Panagiotopoulos N., Gorman P., Khiroya R., Stephens R. C., Wong Y. N. S., Bandula S., Sharp A., Smith S., Gower N., Dhanda H. K., Chan K., Pilotti C., Leslie R., Grapa A., Zhang H., AbdulJabbar K., Pan X., Yuan Y., Chuter D., MacKenzie M., Chee S., Alzetani A., Cave J., Scarlett L., Richards J., Ingram P., Austin S., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Nicholson A. G., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Dick C., Le Quesne J., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., Birkbak N. J., McGranahan N., Swanton C., Abbosh, C, Frankell, A, Harrison, T, Kisistok, J, Garnett, A, Johnson, L, Veeriah, S, Moreau, M, Chesh, A, Chaunzwa, T, Weiss, J, Schroeder, M, Ward, S, Grigoriadis, K, Shahpurwalla, A, Litchfield, K, Puttick, C, Biswas, D, Karasaki, T, Black, J, Martinez-Ruiz, C, Bakir, M, Pich, O, Watkins, T, Lim, E, Huebner, A, Moore, D, Godin-Heymann, N, L'Hernault, A, Bye, H, Odell, A, Roberts, P, Gomes, F, Patel, A, Manzano, E, Hiley, C, Carey, N, Riley, J, Cook, D, Hodgson, D, Stetson, D, Barrett, J, Kortlever, R, Evan, G, Hackshaw, A, Daber, R, Shaw, J, Aerts, H, Licon, A, Stahl, J, Jamal-Hanjani, M, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Ang, K, Tufail, M, Chowdhry, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Fennell, D, Matharu, G, Primrose, L, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, Gilbert, K, Naidu, B, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totten, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Doran, H, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Brown, K, Carter, M, Chaturvedi, A, Priest, L, Oliveira, P, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Kilgour, E, Dive, C, Schwarz, R, Kaufmann, T, Wilson, G, Rosenthal, R, Van Loo, P, Szallasi, Z, Sokac, M, Salgado, R, Diossy, M, Demeulemeester, J, Bunkum, A, Stewart, A, Magness, A, Rowan, A, Karamani, A, Toncheva, A, Chain, B, Campbell, B, Castignani, C, Bailey, C, Weeden, C, Lee, C, Richard, C, Naceur-Lombardelli, C, Pearce, D, Karagianni, D, Levi, D, Hoxha, E, Larose Cadieux, E, Colliver, E, Nye, E, Gronroos, E, Galvez-Cancino, F, Athanasopoulou, F, Gimeno-Valiente, F, Kassiotis, G, Stavrou, G, Mastrokalos, G, Zhai, H, Lowe, H, Matos, I, Goldman, J, Reading, J, Herrero, J, Rane, J, Nicod, J, Lam, J, Hartley, J, Peggs, K, Enfield, K, Selvaraju, K, Thol, K, Ng, K, Chen, K, Dijkstra, K, Thakkar, K, Ensell, L, Shah, M, Vasquez, M, Litovchenko, M, Werner Sunderland, M, Hill, M, Dietzen, M, Leung, M, Escudero, M, Angelova, M, Tanic, M, Sivakumar, M, Kanu, N, Chervova, O, Lucas, O, Al-Sawaf, O, Prymas, P, Hobson, P, Pawlik, P, Stone, R, Bentham, R, Hynds, R, Vendramin, R, Saghafinia, S, Lopez, S, Gamble, S, Ung, S, Quezada, S, Vanloo, S, Zaccaria, S, Hessey, S, Boeing, S, Beck, S, Bola, S, Denner, T, Marafioti, T, Mourikis, T, Spanswick, V, Barbe, V, Lu, W, Hill, W, Liu, W, Wu, Y, Naito, Y, Ramsden, Z, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Clark, T, Forster, M, Lee, S, Borg, E, Falzon, M, Papadatos-Pastos, D, Wilson, J, Ahmad, T, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Janes, S, Martinoni Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Hayward, M, Panagiotopoulos, N, Gorman, P, Khiroya, R, Stephens, R, Wong, Y, Bandula, S, Sharp, A, Smith, S, Gower, N, Dhanda, H, Chan, K, Pilotti, C, Leslie, R, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Yuan, Y, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Cave, J, Scarlett, L, Richards, J, Ingram, P, Austin, S, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Nicholson, A, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Dick, C, Le Quesne, J, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Birkbak, N, Mcgranahan, N, Swanton, C, Abbosh C., Frankell A. M., Harrison T., Kisistok J., Garnett A., Johnson L., Veeriah S., Moreau M., Chesh A., Chaunzwa T. L., Weiss J., Schroeder M. R., Ward S., Grigoriadis K., Shahpurwalla A., Litchfield K., Puttick C., Biswas D., Karasaki T., Black J. R. M., Martinez-Ruiz C., Bakir M. A., Pich O., Watkins T. B. K., Lim E. L., Huebner A., Moore D. A., Godin-Heymann N., L'Hernault A., Bye H., Odell A., Roberts P., Gomes F., Patel A. J., Manzano E., Hiley C. T., Carey N., Riley J., Cook D. E., Hodgson D., Stetson D., Barrett J. C., Kortlever R. M., Evan G. I., Hackshaw A., Daber R. D., Shaw J. A., Aerts H. J. W. L., Licon A., Stahl J., Jamal-Hanjani M., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Ang K., Tufail M., Chowdhry M. F., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Fennell D. A., Matharu G., Primrose L., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., Gilbert K., Naidu B., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totten N., Montero A., Smith E., Fontaine E., Granato F., Doran H., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P., Brown K., Carter M., Chaturvedi A., Priest L., Oliveira P., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Kilgour E., Dive C., Schwarz R. F., Kaufmann T. L., Wilson G. A., Rosenthal R., Van Loo P., Szallasi Z., Sokac M., Salgado R., Diossy M., Demeulemeester J., Bunkum A., Stewart A., Magness A., Rowan A., Karamani A., Toncheva A., Chain B., Campbell B. B., Castignani C., Bailey C., Weeden C. E., Lee C., Richard C., Naceur-Lombardelli C., Pearce D. R., Karagianni D., Levi D., Hoxha E., Larose Cadieux E., Colliver E., Nye E., Gronroos E., Galvez-Cancino F., Athanasopoulou F., Gimeno-Valiente F., Kassiotis G., Stavrou G., Mastrokalos G., Zhai H., Lowe H. L., Matos I., Goldman J., Reading J. L., Herrero J., Rane J. K., Nicod J., Lam J. M., Hartley J. A., Peggs K. S., Enfield K. S. S., Selvaraju K., Thol K., Ng K. W., Chen K., Dijkstra K., Thakkar K., Ensell L., Shah M., Vasquez M., Litovchenko M., Werner Sunderland M., Hill M. S., Dietzen M., Leung M., Escudero M., Angelova M., Tanic M., Sivakumar M., Kanu N., Chervova O., Lucas O., Al-Sawaf O., Prymas P., Hobson P., Pawlik P., Stone R. K., Bentham R., Hynds R. E., Vendramin R., Saghafinia S., Lopez S., Gamble S., Ung S. K. A., Quezada S. A., Vanloo S., Zaccaria S., Hessey S., Boeing S., Beck S., Bola S. K., Denner T., Marafioti T., Mourikis T. P., Spanswick V., Barbe V., Lu W. -T., Hill W., Liu W. K., Wu Y., Naito Y., Ramsden Z., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Clark T., Forster M. D., Lee S. M., Borg E., Falzon M., Papadatos-Pastos D., Wilson J., Ahmad T., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Janes S. M., Martinoni Hoogenboom E., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Hayward M., Panagiotopoulos N., Gorman P., Khiroya R., Stephens R. C., Wong Y. N. S., Bandula S., Sharp A., Smith S., Gower N., Dhanda H. K., Chan K., Pilotti C., Leslie R., Grapa A., Zhang H., AbdulJabbar K., Pan X., Yuan Y., Chuter D., MacKenzie M., Chee S., Alzetani A., Cave J., Scarlett L., Richards J., Ingram P., Austin S., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Nicholson A. G., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Dick C., Le Quesne J., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., Birkbak N. J., McGranahan N., and Swanton C.
Abstract: Circulating tumour DNA (ctDNA) can be used to detect and profile residual tumour cells persisting after curative intent therapy1. The study of large patient cohorts incorporating longitudinal plasma sampling and extended follow-up is required to determine the role of ctDNA as a phylogenetic biomarker of relapse in early-stage non-small-cell lung cancer (NSCLC). Here we developed ctDNA methods tracking a median of 200 mutations identified in resected NSCLC tissue across 1,069 plasma samples collected from 197 patients enrolled in the TRACERx study2. A lack of preoperative ctDNA detection distinguished biologically indolent lung adenocarcinoma with good clinical outcome. Postoperative plasma analyses were interpreted within the context of standard-of-care radiological surveillance and administration of cytotoxic adjuvant therapy. Landmark analyses of plasma samples collected within 120 days after surgery revealed ctDNA detection in 25% of patients, including 49% of all patients who experienced clinical relapse; 3 to 6 monthly ctDNA surveillance identified impending disease relapse in an additional 20% of landmark-negative patients. We developed a bioinformatic tool (ECLIPSE) for non-invasive tracking of subclonal architecture at low ctDNA levels. ECLIPSE identified patients with polyclonal metastatic dissemination, which was associated with a poor clinical outcome. By measuring subclone cancer cell fractions in preoperative plasma, we found that subclones seeding future metastases were significantly more expanded compared with non-metastatic subclones. Our findings will support (neo)adjuvant trial advances and provide insights into the process of metastatic dissemination using low-ctDNA-level liquid biopsy.
Published: 2023

24. Antibodies against endogenous retroviruses promote lung cancer immunotherapy

Author: Ng, K, Boumelha, J, Enfield, K, Almagro, J, Cha, H, Pich, O, Karasaki, T, Moore, D, Salgado, R, Sivakumar, M, Young, G, Molina-Arcas, M, de Carne Trecesson, S, Anastasiou, P, Fendler, A, Au, L, Shepherd, S, Martinez-Ruiz, C, Puttick, C, Black, J, Watkins, T, Kim, H, Shim, S, Faulkner, N, Attig, J, Veeriah, S, Magno, N, Ward, S, Frankell, A, Al Bakir, M, Lim, E, Hill, M, Wilson, G, Cook, D, Birkbak, N, Behrens, A, Yousaf, N, Popat, S, Hackshaw, A, Rowan, A, Huebner, A, Campbell, B, Bailey, C, Lee, C, Biswas, D, Colliver, E, Athanasopoulou, F, Zhai, H, Rane, J, Grigoriadis, K, Dietzen, M, Leung, M, Angelova, M, Lucas, O, Al-Sawaf, O, Rosenthal, R, Nicod, J, Bunkum, A, Toncheva, A, Abbosh, C, Richard, C, Naceur-Lombardelli, C, Gimeno-Valiente, F, Lam, J, Thol, K, Thakkar, K, Werner Sunderland, M, Forster, M, Kanu, N, Prymas, P, Bentham, R, Saghafinia, S, Quezada, S, Vanloo, S, Zaccaria, S, Lee, S, Hessey, S, Liu, W, Papadatos-Pastos, D, Wilson, J, Benafif, S, Ahmad, T, Borg, E, Falzon, M, Khiroya, R, Marafioti, T, Sharp, A, Pilotti, C, Dhanda, H, Chan, K, Gower, N, Leslie, R, Smith, S, Nicholson, A, Herrero, J, Castignani, C, Larose Cadieux, E, Demeulemeester, J, Van Loo, P, Peggs, K, Veiga, C, Royle, G, Collins-Fekete, C, Procter, A, Nair, A, Ahmed, A, Taylor, M, Navani, N, Thakrar, R, Lawrence, D, Patrini, D, Nye, E, Stone, R, Chuter, D, Mackenzie, M, Fraioli, F, Ashford, P, Janes, S, Tanic, M, Beck, S, Rice, A, Devaraj, A, Proli, C, Kaniu, D, Bhayani, H, Chavan, H, Raubenheimer, H, Ambrose, L, Malima, M, Fernandes, N, De Sousa, P, Shah, P, Booth, S, Buderi, S, Jordan, S, Begum, S, Boleti, E, Stewart, A, Magness, A, Weeden, C, Levi, D, Gronroos, E, Goldman, J, Escudero, M, Hobson, P, Vendramin, R, Boeing, S, Denner, T, Barbe, V, Lu, W, Hill, W, Naito, Y, Ramsden, Z, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Gilbert, K, Karamani, A, Chain, B, Pearce, D, Karagianni, D, Hoxha, E, Galvez-Cancino, F, Stavrou, G, Mastrokalos, G, Lowe, H, Matos, I, Reading, J, Hartley, J, Selvaraju, K, Chen, K, Ensell, L, Shah, M, Vasquez, M, Litovchenko, M, Chervova, O, Pawlik, P, Hynds, R, Lopez, S, Gamble, S, Ung, S, Bola, S, Mourikis, T, Spanswick, V, Wu, Y, Martinoni Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Hayward, M, Panagiotopoulos, N, Gorman, P, Stephens, R, Bandula, S, Wong, Y, Clark, T, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Naidu, B, Matharu, G, Shaw, J, Riley, J, Primrose, L, Le Quesne, J, Blyth, K, Kerr, A, Clipson, A, Chaturvedi, A, Dive, C, Rothwell, D, Kilgour, E, Tugwood, J, Priest, L, Oliveira, P, Crosbie, P, Price, G, Cave, J, Kerr, K, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Kirk, A, Thomas, M, Asif, M, Kostoulas, N, Bilancia, R, Middleton, G, Shackcloth, M, Leek, A, Hodgkinson, J, Totten, N, Dick, C, Robinson, L, Russell, P, Hewish, M, Danson, S, Lester, J, Gomes, F, Brown, K, Carter, M, Patel, A, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Alzetani, A, Richards, J, Scarlett, L, Ingram, P, Chee, S, Austin, S, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Fennell, D, Ang, K, Tufail, M, Chowdhry, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Montero, A, Smith, E, Fontaine, E, Granato, F, Doran, H, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Aerts, H, Kaufmann, T, Schwarz, R, Kisistok, J, Sokac, M, Diossy, M, Szallasi, Z, Dijkstra, K, Yuan, Y, Byrne, F, Boos, L, Shum, B, Gerard, C, Schmitt, A, Messiou, C, Cunningham, D, Chau, I, Starling, N, Turner, N, Welsh, L, Jones, R, Droney, J, Banerjee, S, Tatham, K, Jhanji, S, Harrington, K, Okines, A, Reid, A, Young, K, Furness, A, Pickering, L, Nicholson, E, Kumar, S, Wilkinson, K, Swerdlow, A, Wilkinson, R, Hiley, C, Litchfield, K, Mcgranahan, N, Jamal-Hanjani, M, Larkin, J, Turajlic, S, Swanton, C, Downward, J, Kassiotis, G, Ng K. W., Boumelha J., Enfield K. S. S., Almagro J., Cha H., Pich O., Karasaki T., Moore D. A., Salgado R., Sivakumar M., Young G., Molina-Arcas M., de Carne Trecesson S., Anastasiou P., Fendler A., Au L., Shepherd S. T. C., Martinez-Ruiz C., Puttick C., Black J. R. M., Watkins T. B. K., Kim H., Shim S., Faulkner N., Attig J., Veeriah S., Magno N., Ward S., Frankell A. M., Al Bakir M., Lim E. L., Hill M. S., Wilson G. A., Cook D. E., Birkbak N. J., Behrens A., Yousaf N., Popat S., Hackshaw A., Rowan A., Huebner A., Campbell B. B., Bailey C., Lee C., Biswas D., Colliver E., Athanasopoulou F., Zhai H., Rane J. K., Grigoriadis K., Dietzen M., Leung M., Angelova M., Lucas O., Al-Sawaf O., Rosenthal R., Nicod J., Bunkum A., Toncheva A., Abbosh C., Richard C., Naceur-Lombardelli C., Gimeno-Valiente F., Lam J. M., Thol K., Thakkar K., Werner Sunderland M., Forster M. D., Kanu N., Prymas P., Bentham R., Saghafinia S., Quezada S. A., Vanloo S., Zaccaria S., Lee S. M., Hessey S., Liu W. K., Papadatos-Pastos D., Wilson J., Benafif S., Ahmad T., Borg E., Falzon M., Khiroya R., Marafioti T., Sharp A., Pilotti C., Dhanda H. K., Chan K., Gower N., Leslie R., Smith S., Nicholson A. G., Lim E., Herrero J., Castignani C., Larose Cadieux E., Demeulemeester J., Van Loo P., Peggs K. S., Veiga C., Royle G., Collins-Fekete C. -A., Procter A. J., Nair A., Ahmed A., Taylor M. N., Navani N., Thakrar R. M., Lawrence D., Patrini D., Nye E., Stone R. K., Chuter D., MacKenzie M., Fraioli F., Ashford P., Janes S. M., Tanic M., Beck S., Rice A., Devaraj A., Proli C., Kaniu D., Bhayani H., Chavan H., Raubenheimer H., Ambrose L., Malima M., Fernandes N., De Sousa P., Shah P., Booth S., Buderi S. I., Jordan S., Begum S., Boleti E., Stewart A., Magness A., Weeden C. E., Levi D., Gronroos E., Goldman J., Escudero M., Hobson P., Vendramin R., Boeing S., Denner T., Barbe V., Lu W. -T., Hill W., Naito Y., Ramsden Z., Grapa A., Zhang H., AbdulJabbar K., Pan X., Gilbert K., Karamani A., Chain B., Pearce D. R., Karagianni D., Hoxha E., Galvez-Cancino F., Stavrou G., Mastrokalos G., Lowe H. L., Matos I., Reading J. L., Hartley J. A., Selvaraju K., Chen K., Ensell L., Shah M., Vasquez M., Litovchenko M., Chervova O., Pawlik P., Hynds R. E., Lopez S., Gamble S., Ung S. K. A., Bola S. K., Mourikis T. P., Spanswick V., Wu Y., Martinoni Hoogenboom E., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Hayward M., Panagiotopoulos N., Gorman P., Stephens R. C. M., Bandula S., Wong Y. N. S., Clark T., Cheyne H., Khalil M., Richardson S., Cruickshank T., Naidu B., Matharu G., Shaw J. A., Riley J., Primrose L., Le Quesne J., Blyth K. G., Kerr A., Clipson A., Chaturvedi A., Dive C., Rothwell D. G., Kilgour E., Tugwood J., Priest L., Oliveira P., Crosbie P., Price G., Cave J., Kerr K. M., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Kirk A., Thomas M., Asif M., Kostoulas N., Bilancia R., Middleton G., Shackcloth M. J., Leek A., Hodgkinson J. D., Totten N., Dick C., Robinson L., Russell P., Hewish M., Danson S., Lester J. F., Gomes F., Brown K., Carter M., Patel A. J., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Alzetani A., Richards J., Scarlett L., Ingram P., Chee S., Austin S., Bajaj A., Nakas A., Sodha-Ramdeen A., Fennell D. A., Ang K., Tufail M., Chowdhry M. F., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Montero A., Smith E., Fontaine E., Granato F., Doran H., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Aerts H. J. W. L., Kaufmann T. L., Schwarz R. F., Kisistok J., Sokac M., Diossy M., Szallasi Z., Dijkstra K., Yuan Y., Byrne F., Boos L. A., Shum B., Gerard C. L., Schmitt A. M., Messiou C., Cunningham D., Chau I., Starling N., Turner N., Welsh L., Jones R. L., Droney J., Banerjee S., Tatham K. C., Jhanji S., Harrington K., Okines A., Reid A., Young K., Furness A. J. S., Pickering L., Nicholson E., Kumar S., Wilkinson K. A., Swerdlow A., Wilkinson R. J., Hiley C. T., Litchfield K., McGranahan N., Jamal-Hanjani M., Larkin J., Lee S. -H., Turajlic S., Swanton C., Downward J., Kassiotis G., Ng, K, Boumelha, J, Enfield, K, Almagro, J, Cha, H, Pich, O, Karasaki, T, Moore, D, Salgado, R, Sivakumar, M, Young, G, Molina-Arcas, M, de Carne Trecesson, S, Anastasiou, P, Fendler, A, Au, L, Shepherd, S, Martinez-Ruiz, C, Puttick, C, Black, J, Watkins, T, Kim, H, Shim, S, Faulkner, N, Attig, J, Veeriah, S, Magno, N, Ward, S, Frankell, A, Al Bakir, M, Lim, E, Hill, M, Wilson, G, Cook, D, Birkbak, N, Behrens, A, Yousaf, N, Popat, S, Hackshaw, A, Rowan, A, Huebner, A, Campbell, B, Bailey, C, Lee, C, Biswas, D, Colliver, E, Athanasopoulou, F, Zhai, H, Rane, J, Grigoriadis, K, Dietzen, M, Leung, M, Angelova, M, Lucas, O, Al-Sawaf, O, Rosenthal, R, Nicod, J, Bunkum, A, Toncheva, A, Abbosh, C, Richard, C, Naceur-Lombardelli, C, Gimeno-Valiente, F, Lam, J, Thol, K, Thakkar, K, Werner Sunderland, M, Forster, M, Kanu, N, Prymas, P, Bentham, R, Saghafinia, S, Quezada, S, Vanloo, S, Zaccaria, S, Lee, S, Hessey, S, Liu, W, Papadatos-Pastos, D, Wilson, J, Benafif, S, Ahmad, T, Borg, E, Falzon, M, Khiroya, R, Marafioti, T, Sharp, A, Pilotti, C, Dhanda, H, Chan, K, Gower, N, Leslie, R, Smith, S, Nicholson, A, Herrero, J, Castignani, C, Larose Cadieux, E, Demeulemeester, J, Van Loo, P, Peggs, K, Veiga, C, Royle, G, Collins-Fekete, C, Procter, A, Nair, A, Ahmed, A, Taylor, M, Navani, N, Thakrar, R, Lawrence, D, Patrini, D, Nye, E, Stone, R, Chuter, D, Mackenzie, M, Fraioli, F, Ashford, P, Janes, S, Tanic, M, Beck, S, Rice, A, Devaraj, A, Proli, C, Kaniu, D, Bhayani, H, Chavan, H, Raubenheimer, H, Ambrose, L, Malima, M, Fernandes, N, De Sousa, P, Shah, P, Booth, S, Buderi, S, Jordan, S, Begum, S, Boleti, E, Stewart, A, Magness, A, Weeden, C, Levi, D, Gronroos, E, Goldman, J, Escudero, M, Hobson, P, Vendramin, R, Boeing, S, Denner, T, Barbe, V, Lu, W, Hill, W, Naito, Y, Ramsden, Z, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Gilbert, K, Karamani, A, Chain, B, Pearce, D, Karagianni, D, Hoxha, E, Galvez-Cancino, F, Stavrou, G, Mastrokalos, G, Lowe, H, Matos, I, Reading, J, Hartley, J, Selvaraju, K, Chen, K, Ensell, L, Shah, M, Vasquez, M, Litovchenko, M, Chervova, O, Pawlik, P, Hynds, R, Lopez, S, Gamble, S, Ung, S, Bola, S, Mourikis, T, Spanswick, V, Wu, Y, Martinoni Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Hayward, M, Panagiotopoulos, N, Gorman, P, Stephens, R, Bandula, S, Wong, Y, Clark, T, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Naidu, B, Matharu, G, Shaw, J, Riley, J, Primrose, L, Le Quesne, J, Blyth, K, Kerr, A, Clipson, A, Chaturvedi, A, Dive, C, Rothwell, D, Kilgour, E, Tugwood, J, Priest, L, Oliveira, P, Crosbie, P, Price, G, Cave, J, Kerr, K, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Kirk, A, Thomas, M, Asif, M, Kostoulas, N, Bilancia, R, Middleton, G, Shackcloth, M, Leek, A, Hodgkinson, J, Totten, N, Dick, C, Robinson, L, Russell, P, Hewish, M, Danson, S, Lester, J, Gomes, F, Brown, K, Carter, M, Patel, A, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Alzetani, A, Richards, J, Scarlett, L, Ingram, P, Chee, S, Austin, S, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Fennell, D, Ang, K, Tufail, M, Chowdhry, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Montero, A, Smith, E, Fontaine, E, Granato, F, Doran, H, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Aerts, H, Kaufmann, T, Schwarz, R, Kisistok, J, Sokac, M, Diossy, M, Szallasi, Z, Dijkstra, K, Yuan, Y, Byrne, F, Boos, L, Shum, B, Gerard, C, Schmitt, A, Messiou, C, Cunningham, D, Chau, I, Starling, N, Turner, N, Welsh, L, Jones, R, Droney, J, Banerjee, S, Tatham, K, Jhanji, S, Harrington, K, Okines, A, Reid, A, Young, K, Furness, A, Pickering, L, Nicholson, E, Kumar, S, Wilkinson, K, Swerdlow, A, Wilkinson, R, Hiley, C, Litchfield, K, Mcgranahan, N, Jamal-Hanjani, M, Larkin, J, Turajlic, S, Swanton, C, Downward, J, Kassiotis, G, Ng K. W., Boumelha J., Enfield K. S. S., Almagro J., Cha H., Pich O., Karasaki T., Moore D. A., Salgado R., Sivakumar M., Young G., Molina-Arcas M., de Carne Trecesson S., Anastasiou P., Fendler A., Au L., Shepherd S. T. C., Martinez-Ruiz C., Puttick C., Black J. R. M., Watkins T. B. K., Kim H., Shim S., Faulkner N., Attig J., Veeriah S., Magno N., Ward S., Frankell A. M., Al Bakir M., Lim E. L., Hill M. S., Wilson G. A., Cook D. E., Birkbak N. J., Behrens A., Yousaf N., Popat S., Hackshaw A., Rowan A., Huebner A., Campbell B. B., Bailey C., Lee C., Biswas D., Colliver E., Athanasopoulou F., Zhai H., Rane J. K., Grigoriadis K., Dietzen M., Leung M., Angelova M., Lucas O., Al-Sawaf O., Rosenthal R., Nicod J., Bunkum A., Toncheva A., Abbosh C., Richard C., Naceur-Lombardelli C., Gimeno-Valiente F., Lam J. M., Thol K., Thakkar K., Werner Sunderland M., Forster M. D., Kanu N., Prymas P., Bentham R., Saghafinia S., Quezada S. A., Vanloo S., Zaccaria S., Lee S. M., Hessey S., Liu W. K., Papadatos-Pastos D., Wilson J., Benafif S., Ahmad T., Borg E., Falzon M., Khiroya R., Marafioti T., Sharp A., Pilotti C., Dhanda H. K., Chan K., Gower N., Leslie R., Smith S., Nicholson A. G., Lim E., Herrero J., Castignani C., Larose Cadieux E., Demeulemeester J., Van Loo P., Peggs K. S., Veiga C., Royle G., Collins-Fekete C. -A., Procter A. J., Nair A., Ahmed A., Taylor M. N., Navani N., Thakrar R. M., Lawrence D., Patrini D., Nye E., Stone R. K., Chuter D., MacKenzie M., Fraioli F., Ashford P., Janes S. M., Tanic M., Beck S., Rice A., Devaraj A., Proli C., Kaniu D., Bhayani H., Chavan H., Raubenheimer H., Ambrose L., Malima M., Fernandes N., De Sousa P., Shah P., Booth S., Buderi S. I., Jordan S., Begum S., Boleti E., Stewart A., Magness A., Weeden C. E., Levi D., Gronroos E., Goldman J., Escudero M., Hobson P., Vendramin R., Boeing S., Denner T., Barbe V., Lu W. -T., Hill W., Naito Y., Ramsden Z., Grapa A., Zhang H., AbdulJabbar K., Pan X., Gilbert K., Karamani A., Chain B., Pearce D. R., Karagianni D., Hoxha E., Galvez-Cancino F., Stavrou G., Mastrokalos G., Lowe H. L., Matos I., Reading J. L., Hartley J. A., Selvaraju K., Chen K., Ensell L., Shah M., Vasquez M., Litovchenko M., Chervova O., Pawlik P., Hynds R. E., Lopez S., Gamble S., Ung S. K. A., Bola S. K., Mourikis T. P., Spanswick V., Wu Y., Martinoni Hoogenboom E., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Hayward M., Panagiotopoulos N., Gorman P., Stephens R. C. M., Bandula S., Wong Y. N. S., Clark T., Cheyne H., Khalil M., Richardson S., Cruickshank T., Naidu B., Matharu G., Shaw J. A., Riley J., Primrose L., Le Quesne J., Blyth K. G., Kerr A., Clipson A., Chaturvedi A., Dive C., Rothwell D. G., Kilgour E., Tugwood J., Priest L., Oliveira P., Crosbie P., Price G., Cave J., Kerr K. M., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Kirk A., Thomas M., Asif M., Kostoulas N., Bilancia R., Middleton G., Shackcloth M. J., Leek A., Hodgkinson J. D., Totten N., Dick C., Robinson L., Russell P., Hewish M., Danson S., Lester J. F., Gomes F., Brown K., Carter M., Patel A. J., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Alzetani A., Richards J., Scarlett L., Ingram P., Chee S., Austin S., Bajaj A., Nakas A., Sodha-Ramdeen A., Fennell D. A., Ang K., Tufail M., Chowdhry M. F., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Montero A., Smith E., Fontaine E., Granato F., Doran H., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Aerts H. J. W. L., Kaufmann T. L., Schwarz R. F., Kisistok J., Sokac M., Diossy M., Szallasi Z., Dijkstra K., Yuan Y., Byrne F., Boos L. A., Shum B., Gerard C. L., Schmitt A. M., Messiou C., Cunningham D., Chau I., Starling N., Turner N., Welsh L., Jones R. L., Droney J., Banerjee S., Tatham K. C., Jhanji S., Harrington K., Okines A., Reid A., Young K., Furness A. J. S., Pickering L., Nicholson E., Kumar S., Wilkinson K. A., Swerdlow A., Wilkinson R. J., Hiley C. T., Litchfield K., McGranahan N., Jamal-Hanjani M., Larkin J., Lee S. -H., Turajlic S., Swanton C., Downward J., and Kassiotis G.
Abstract: B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS)1,2. Although TLS have been found to correlate with improved patient survival and response to immune checkpoint blockade (ICB), the underlying mechanisms of this association remain elusive1,2. Here we investigate lung-resident B cell responses in patients from the TRACERx 421 (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy) and other lung cancer cohorts, and in a recently established immunogenic mouse model for lung adenocarcinoma3. We find that both human and mouse lung adenocarcinomas elicit local germinal centre responses and tumour-binding antibodies, and further identify endogenous retrovirus (ERV) envelope glycoproteins as a dominant anti-tumour antibody target. ERV-targeting B cell responses are amplified by ICB in both humans and mice, and by targeted inhibition of KRAS(G12C) in the mouse model. ERV-reactive antibodies exert anti-tumour activity that extends survival in the mouse model, and ERV expression predicts the outcome of ICB in human lung adenocarcinoma. Finally, we find that effective immunotherapy in the mouse model requires CXCL13-dependent TLS formation. Conversely, therapeutic CXCL13 treatment potentiates anti-tumour immunity and synergizes with ICB. Our findings provide a possible mechanistic basis for the association of TLS with immunotherapy response.
Published: 2023

25. The evolution of lung cancer and impact of subclonal selection in TRACERx

Author: Frankell, A, Dietzen, M, Al Bakir, M, Lim, E, Karasaki, T, Ward, S, Veeriah, S, Colliver, E, Huebner, A, Bunkum, A, Hill, M, Grigoriadis, K, Moore, D, Black, J, Liu, W, Thol, K, Pich, O, Watkins, T, Naceur-Lombardelli, C, Cook, D, Salgado, R, Wilson, G, Bailey, C, Angelova, M, Bentham, R, Martinez-Ruiz, C, Abbosh, C, Nicholson, A, Le Quesne, J, Biswas, D, Rosenthal, R, Puttick, C, Hessey, S, Lee, C, Prymas, P, Toncheva, A, Smith, J, Xing, W, Nicod, J, Price, G, Kerr, K, Naidu, B, Middleton, G, Blyth, K, Fennell, D, Forster, M, Lee, S, Falzon, M, Hewish, M, Shackcloth, M, Benafif, S, Russell, P, Boleti, E, Krebs, M, Lester, J, Papadatos-Pastos, D, Ahmad, T, Thakrar, R, Lawrence, D, Navani, N, Janes, S, Dive, C, Blackhall, F, Summers, Y, Cave, J, Marafioti, T, Herrero, J, Quezada, S, Peggs, K, Schwarz, R, Van Loo, P, Miedema, D, Birkbak, N, Hiley, C, Hackshaw, A, Zaccaria, S, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Ang, K, Tufail, M, Chowdhry, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Matharu, G, Shaw, J, Riley, J, Primrose, L, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Gilbert, K, Patel, A, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Leek, A, Hodgkinson, J, Totten, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Doran, H, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Gomes, F, Brown, K, Carter, M, Chaturvedi, A, Priest, L, Oliveira, P, Lindsay, C, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Kilgour, E, Aerts, H, Kaufmann, T, Szallasi, Z, Kisistok, J, Sokac, M, Diossy, M, Demeulemeester, J, Stewart, A, Magness, A, Rowan, A, Karamani, A, Chain, B, Campbell, B, Castignani, C, Weeden, C, Richard, C, Pearce, D, Karagianni, D, Levi, D, Hoxha, E, Larose Cadieux, E, Nye, E, Gronroos, E, Galvez-Cancino, F, Athanasopoulou, F, Gimeno-Valiente, F, Kassiotis, G, Stavrou, G, Mastrokalos, G, Zhai, H, Lowe, H, Matos, I, Goldman, J, Reading, J, Rane, J, Lam, J, Hartley, J, Enfield, K, Selvaraju, K, Litchfield, K, Ng, K, Chen, K, Dijkstra, K, Thakkar, K, Ensell, L, Shah, M, Vasquez, M, Litovchenko, M, Werner Sunderland, M, Leung, M, Escudero, M, Tanic, M, Sivakumar, M, Kanu, N, Chervova, O, Lucas, O, Al-Sawaf, O, Hobson, P, Pawlik, P, Stone, R, Hynds, R, Vendramin, R, Saghafinia, S, Lopez, S, Gamble, S, Ung, S, Vanloo, S, Boeing, S, Beck, S, Bola, S, Denner, T, Mourikis, T, Spanswick, V, Barbe, V, Lu, W, Hill, W, Wu, Y, Naito, Y, Ramsden, Z, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Clark, T, Borg, E, Wilson, J, Procter, A, Ahmed, A, Taylor, M, Nair, A, Patrini, D, Martinoni Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Hayward, M, Panagiotopoulos, N, Gorman, P, Khiroya, R, Stephens, R, Wong, Y, Bandula, S, Sharp, A, Smith, S, Gower, N, Dhanda, H, Chan, K, Pilotti, C, Leslie, R, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Yuan, Y, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Scarlett, L, Richards, J, Ingram, P, Austin, S, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Fernandes, N, Shah, P, Proli, C, Danson, S, Robinson, L, Dick, C, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Jamal-Hanjani, M, Mcgranahan, N, Swanton, C, Frankell A. M., Dietzen M., Al Bakir M., Lim E. L., Karasaki T., Ward S., Veeriah S., Colliver E., Huebner A., Bunkum A., Hill M. S., Grigoriadis K., Moore D. A., Black J. R. M., Liu W. K., Thol K., Pich O., Watkins T. B. K., Naceur-Lombardelli C., Cook D. E., Salgado R., Wilson G. A., Bailey C., Angelova M., Bentham R., Martinez-Ruiz C., Abbosh C., Nicholson A. G., Le Quesne J., Biswas D., Rosenthal R., Puttick C., Hessey S., Lee C., Prymas P., Toncheva A., Smith J., Xing W., Nicod J., Price G., Kerr K. M., Naidu B., Middleton G., Blyth K. G., Fennell D. A., Forster M. D., Lee S. M., Falzon M., Hewish M., Shackcloth M. J., Lim E., Benafif S., Russell P., Boleti E., Krebs M. G., Lester J. F., Papadatos-Pastos D., Ahmad T., Thakrar R. M., Lawrence D., Navani N., Janes S. M., Dive C., Blackhall F. H., Summers Y., Cave J., Marafioti T., Herrero J., Quezada S. A., Peggs K. S., Schwarz R. F., Van Loo P., Miedema D. M., Birkbak N. J., Hiley C. T., Hackshaw A., Zaccaria S., Bajaj A., Nakas A., Sodha-Ramdeen A., Ang K., Tufail M., Chowdhry M. F., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Matharu G., Shaw J. A., Riley J., Primrose L., Cheyne H., Khalil M., Richardson S., Cruickshank T., Gilbert K., Patel A. J., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Leek A., Hodgkinson J. D., Totten N., Montero A., Smith E., Fontaine E., Granato F., Doran H., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P., Gomes F., Brown K., Carter M., Chaturvedi A., Priest L., Oliveira P., Lindsay C. R., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Kilgour E., Aerts H. J. W. L., Kaufmann T. L., Szallasi Z., Kisistok J., Sokac M., Diossy M., Demeulemeester J., Stewart A., Magness A., Rowan A., Karamani A., Chain B., Campbell B. B., Castignani C., Weeden C. E., Richard C., Pearce D. R., Karagianni D., Levi D., Hoxha E., Larose Cadieux E., Nye E., Gronroos E., Galvez-Cancino F., Athanasopoulou F., Gimeno-Valiente F., Kassiotis G., Stavrou G., Mastrokalos G., Zhai H., Lowe H. L., Matos I., Goldman J., Reading J. L., Rane J. K., Lam J. M., Hartley J. A., Enfield K. S. S., Selvaraju K., Litchfield K., Ng K. W., Chen K., Dijkstra K., Thakkar K., Ensell L., Shah M., Vasquez M., Litovchenko M., Werner Sunderland M., Leung M., Escudero M., Tanic M., Sivakumar M., Kanu N., Chervova O., Lucas O., Al-Sawaf O., Hobson P., Pawlik P., Stone R. K., Hynds R. E., Vendramin R., Saghafinia S., Lopez S., Gamble S., Ung S. K. A., Vanloo S., Boeing S., Beck S., Bola S. K., Denner T., Mourikis T. P., Spanswick V., Barbe V., Lu W. -T., Hill W., Wu Y., Naito Y., Ramsden Z., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Clark T., Borg E., Wilson J., Procter A. J., Ahmed A., Taylor M. N., Nair A., Patrini D., Martinoni Hoogenboom E., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Hayward M., Panagiotopoulos N., Gorman P., Khiroya R., Stephens R. C., Wong Y. N. S., Bandula S., Sharp A., Smith S., Gower N., Dhanda H. K., Chan K., Pilotti C., Leslie R., Grapa A., Zhang H., AbdulJabbar K., Pan X., Yuan Y., Chuter D., MacKenzie M., Chee S., Alzetani A., Scarlett L., Richards J., Ingram P., Austin S., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Fernandes N., Shah P., Proli C., Danson S., Robinson L., Dick C., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., Jamal-Hanjani M., McGranahan N., Swanton C., Frankell, A, Dietzen, M, Al Bakir, M, Lim, E, Karasaki, T, Ward, S, Veeriah, S, Colliver, E, Huebner, A, Bunkum, A, Hill, M, Grigoriadis, K, Moore, D, Black, J, Liu, W, Thol, K, Pich, O, Watkins, T, Naceur-Lombardelli, C, Cook, D, Salgado, R, Wilson, G, Bailey, C, Angelova, M, Bentham, R, Martinez-Ruiz, C, Abbosh, C, Nicholson, A, Le Quesne, J, Biswas, D, Rosenthal, R, Puttick, C, Hessey, S, Lee, C, Prymas, P, Toncheva, A, Smith, J, Xing, W, Nicod, J, Price, G, Kerr, K, Naidu, B, Middleton, G, Blyth, K, Fennell, D, Forster, M, Lee, S, Falzon, M, Hewish, M, Shackcloth, M, Benafif, S, Russell, P, Boleti, E, Krebs, M, Lester, J, Papadatos-Pastos, D, Ahmad, T, Thakrar, R, Lawrence, D, Navani, N, Janes, S, Dive, C, Blackhall, F, Summers, Y, Cave, J, Marafioti, T, Herrero, J, Quezada, S, Peggs, K, Schwarz, R, Van Loo, P, Miedema, D, Birkbak, N, Hiley, C, Hackshaw, A, Zaccaria, S, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Ang, K, Tufail, M, Chowdhry, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Matharu, G, Shaw, J, Riley, J, Primrose, L, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Gilbert, K, Patel, A, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Leek, A, Hodgkinson, J, Totten, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Doran, H, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Gomes, F, Brown, K, Carter, M, Chaturvedi, A, Priest, L, Oliveira, P, Lindsay, C, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Kilgour, E, Aerts, H, Kaufmann, T, Szallasi, Z, Kisistok, J, Sokac, M, Diossy, M, Demeulemeester, J, Stewart, A, Magness, A, Rowan, A, Karamani, A, Chain, B, Campbell, B, Castignani, C, Weeden, C, Richard, C, Pearce, D, Karagianni, D, Levi, D, Hoxha, E, Larose Cadieux, E, Nye, E, Gronroos, E, Galvez-Cancino, F, Athanasopoulou, F, Gimeno-Valiente, F, Kassiotis, G, Stavrou, G, Mastrokalos, G, Zhai, H, Lowe, H, Matos, I, Goldman, J, Reading, J, Rane, J, Lam, J, Hartley, J, Enfield, K, Selvaraju, K, Litchfield, K, Ng, K, Chen, K, Dijkstra, K, Thakkar, K, Ensell, L, Shah, M, Vasquez, M, Litovchenko, M, Werner Sunderland, M, Leung, M, Escudero, M, Tanic, M, Sivakumar, M, Kanu, N, Chervova, O, Lucas, O, Al-Sawaf, O, Hobson, P, Pawlik, P, Stone, R, Hynds, R, Vendramin, R, Saghafinia, S, Lopez, S, Gamble, S, Ung, S, Vanloo, S, Boeing, S, Beck, S, Bola, S, Denner, T, Mourikis, T, Spanswick, V, Barbe, V, Lu, W, Hill, W, Wu, Y, Naito, Y, Ramsden, Z, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Clark, T, Borg, E, Wilson, J, Procter, A, Ahmed, A, Taylor, M, Nair, A, Patrini, D, Martinoni Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Hayward, M, Panagiotopoulos, N, Gorman, P, Khiroya, R, Stephens, R, Wong, Y, Bandula, S, Sharp, A, Smith, S, Gower, N, Dhanda, H, Chan, K, Pilotti, C, Leslie, R, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Yuan, Y, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Scarlett, L, Richards, J, Ingram, P, Austin, S, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Fernandes, N, Shah, P, Proli, C, Danson, S, Robinson, L, Dick, C, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Jamal-Hanjani, M, Mcgranahan, N, Swanton, C, Frankell A. M., Dietzen M., Al Bakir M., Lim E. L., Karasaki T., Ward S., Veeriah S., Colliver E., Huebner A., Bunkum A., Hill M. S., Grigoriadis K., Moore D. A., Black J. R. M., Liu W. K., Thol K., Pich O., Watkins T. B. K., Naceur-Lombardelli C., Cook D. E., Salgado R., Wilson G. A., Bailey C., Angelova M., Bentham R., Martinez-Ruiz C., Abbosh C., Nicholson A. G., Le Quesne J., Biswas D., Rosenthal R., Puttick C., Hessey S., Lee C., Prymas P., Toncheva A., Smith J., Xing W., Nicod J., Price G., Kerr K. M., Naidu B., Middleton G., Blyth K. G., Fennell D. A., Forster M. D., Lee S. M., Falzon M., Hewish M., Shackcloth M. J., Lim E., Benafif S., Russell P., Boleti E., Krebs M. G., Lester J. F., Papadatos-Pastos D., Ahmad T., Thakrar R. M., Lawrence D., Navani N., Janes S. M., Dive C., Blackhall F. H., Summers Y., Cave J., Marafioti T., Herrero J., Quezada S. A., Peggs K. S., Schwarz R. F., Van Loo P., Miedema D. M., Birkbak N. J., Hiley C. T., Hackshaw A., Zaccaria S., Bajaj A., Nakas A., Sodha-Ramdeen A., Ang K., Tufail M., Chowdhry M. F., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Matharu G., Shaw J. A., Riley J., Primrose L., Cheyne H., Khalil M., Richardson S., Cruickshank T., Gilbert K., Patel A. J., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Leek A., Hodgkinson J. D., Totten N., Montero A., Smith E., Fontaine E., Granato F., Doran H., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P., Gomes F., Brown K., Carter M., Chaturvedi A., Priest L., Oliveira P., Lindsay C. R., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Kilgour E., Aerts H. J. W. L., Kaufmann T. L., Szallasi Z., Kisistok J., Sokac M., Diossy M., Demeulemeester J., Stewart A., Magness A., Rowan A., Karamani A., Chain B., Campbell B. B., Castignani C., Weeden C. E., Richard C., Pearce D. R., Karagianni D., Levi D., Hoxha E., Larose Cadieux E., Nye E., Gronroos E., Galvez-Cancino F., Athanasopoulou F., Gimeno-Valiente F., Kassiotis G., Stavrou G., Mastrokalos G., Zhai H., Lowe H. L., Matos I., Goldman J., Reading J. L., Rane J. K., Lam J. M., Hartley J. A., Enfield K. S. S., Selvaraju K., Litchfield K., Ng K. W., Chen K., Dijkstra K., Thakkar K., Ensell L., Shah M., Vasquez M., Litovchenko M., Werner Sunderland M., Leung M., Escudero M., Tanic M., Sivakumar M., Kanu N., Chervova O., Lucas O., Al-Sawaf O., Hobson P., Pawlik P., Stone R. K., Hynds R. E., Vendramin R., Saghafinia S., Lopez S., Gamble S., Ung S. K. A., Vanloo S., Boeing S., Beck S., Bola S. K., Denner T., Mourikis T. P., Spanswick V., Barbe V., Lu W. -T., Hill W., Wu Y., Naito Y., Ramsden Z., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Clark T., Borg E., Wilson J., Procter A. J., Ahmed A., Taylor M. N., Nair A., Patrini D., Martinoni Hoogenboom E., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Hayward M., Panagiotopoulos N., Gorman P., Khiroya R., Stephens R. C., Wong Y. N. S., Bandula S., Sharp A., Smith S., Gower N., Dhanda H. K., Chan K., Pilotti C., Leslie R., Grapa A., Zhang H., AbdulJabbar K., Pan X., Yuan Y., Chuter D., MacKenzie M., Chee S., Alzetani A., Scarlett L., Richards J., Ingram P., Austin S., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Fernandes N., Shah P., Proli C., Danson S., Robinson L., Dick C., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., Jamal-Hanjani M., McGranahan N., and Swanton C.
Abstract: Lung cancer is the leading cause of cancer-associated mortality worldwide1. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher lung cancer evolution and address the primary study endpoint: determining the relationship between intratumour heterogeneity and clinical outcome. In lung adenocarcinoma, mutations in 22 out of 40 common cancer genes were under significant subclonal selection, including classical tumour initiators such as TP53 and KRAS. We defined evolutionary dependencies between drivers, mutational processes and whole genome doubling (WGD) events. Despite patients having a history of smoking, 8% of lung adenocarcinomas lacked evidence of tobacco-induced mutagenesis. These tumours also had similar detection rates for EGFR mutations and for RET, ROS1, ALK and MET oncogenic isoforms compared with tumours in never-smokers, which suggests that they have a similar aetiology and pathogenesis. Large subclonal expansions were associated with positive subclonal selection. Patients with tumours harbouring recent subclonal expansions, on the terminus of a phylogenetic branch, had significantly shorter disease-free survival. Subclonal WGD was detected in 19% of tumours, and 10% of tumours harboured multiple subclonal WGDs in parallel. Subclonal, but not truncal, WGD was associated with shorter disease-free survival. Copy number heterogeneity was associated with extrathoracic relapse within 1 year after surgery. These data demonstrate the importance of clonal expansion, WGD and copy number instability in determining the timing and patterns of relapse in non-small cell lung cancer and provide a comprehensive clinical cancer evolutionary data resource.
Published: 2023

26. The surgical treatment of unilateral vocal cord paralysis (UVCP): qualitative review analysis and meta-analysis study

Author: Granato, F., Martelli, F., Comini, L. V., Luparello, P., Coscarelli, S., Le Seac, O., Carucci, S., Graziani, P., Santoro, R., Alderotti, G., Barillari, M. R., and Mannelli, Giuditta
Published: 2019
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27. THE DARKSIDE-50 EXPERIMENT: A LIQUID ARGON TARGET FOR DARK MATTER PARTICLES

Author: Agnes, P., primary, Agostino, L., additional, Albuquerque, I. F. M., additional, Alexander, T., additional, Alton, A. K., additional, Arisaka, K., additional, Back, H. O., additional, Baldin, B., additional, Biery, K., additional, Bonfini, G., additional, Bossa, M., additional, Bottino, B., additional, Brigatti, A., additional, Brodsky, J., additional, Budano, F., additional, Bussino, S., additional, Cadeddu, M., additional, Cadonati, L., additional, Cadoni, M., additional, Calaprice, F., additional, Canci, N., additional, Candela, A., additional, Cao, H., additional, Cariello, M., additional, Carlini, M., additional, Catalanotti, S., additional, Cavalcante, P., additional, Chepurnov, A., additional, Cocco, A. G., additional, Covone, G., additional, Crippa, L., additional, D’Angelo, D., additional, D’Incecco, M., additional, Davini, S., additional, De Cecco, S., additional, De Deo, M., additional, De Vincenzi, M., additional, Derbin, A., additional, Devoto, A., additional, Di Eusanio, F., additional, Di Pietro, G., additional, Edkins, E., additional, Empl, A., additional, Fan, A., additional, Fiorillo, G., additional, Fomenko, K., additional, Forster, G., additional, Franco, D., additional, Gabriele, F., additional, Galbiati, C., additional, Giganti, C., additional, Goretti, A. M., additional, Granato, F., additional, Grandi, L., additional, Gromov, M., additional, Guan, M., additional, Guardincerri, Y., additional, Hackett, B. R., additional, Herner, K., additional, Hungerford, E. V., additional, Ianni, Al., additional, Ianni, An., additional, James, I., additional, Jollet, C., additional, Keeter, K., additional, Kendziora, C. L., additional, Kobychev, V., additional, Koh, G., additional, Korablev, D., additional, Korga, G., additional, Kubankin, A., additional, Li, X., additional, Lissia, M., additional, Lombardi, P., additional, Luitz, S., additional, Ma, Y., additional, Machulin, I. N., additional, Mandarano, A., additional, Mari, S. M., additional, Maricic, J., additional, Marini, L., additional, Martoff, C J., additional, Meregaglia, A., additional, Meyers, P. D., additional, Miletic, T., additional, Milincic, R., additional, Montanari, D., additional, Monte, A., additional, Montuschi, M., additional, Monzani, M., additional, Mosteiro, P., additional, Mount, B. J., additional, Muratova, V. N., additional, Musico, P., additional, Napolitano, J., additional, Nelson, A., additional, Odrowski, S., additional, Orsini, M., additional, Ortica, F., additional, Pagani, L., additional, Pallavicini, M., additional, Pantic, E., additional, Parmeggiano, S., additional, Pelczar, K., additional, Pelliccia, N., additional, Perasso, S., additional, Pocar, A., additional, Pordes, S., additional, Pugachev, D. A., additional, Qian, H., additional, Randle, K., additional, Ranucci, G., additional, Razeto, A., additional, Reinhold, B., additional, Renshaw, A. L., additional, Romani, A., additional, Rossi, B., additional, Rossi, N., additional, Rountree, D., additional, Sablone, D., additional, Saggese, P., additional, Saldanha, R., additional, Sands, W., additional, Sangiorgio, S., additional, Savarese, C., additional, Segreto, E., additional, Semenov, D. A., additional, Shields, E., additional, Singh, P. N., additional, Skorokhvatov, M. D., additional, Smirnov, O., additional, Sotnikov, A., additional, Stanford, C., additional, Suvorov, Y., additional, Tartaglia, R., additional, Tatarowicz, J., additional, Testera, G., additional, Tonazzo, A., additional, Trinchese, P., additional, Unzhakov, E. V., additional, Vishneva, A., additional, Vogelaar, B., additional, Wada, M., additional, Walker, S., additional, Wang, H., additional, Wang, Y., additional, Watson, A. W., additional, Westerdale, S., additional, Wilhelmi, J., additional, Wojcik, M. M., additional, Xiang, X., additional, Xu, J., additional, Yang, C., additional, Yoo, J., additional, Zavatarelli, S., additional, Zec, A., additional, Zhong, W., additional, Zhu, C., additional, and Zuzel, G., additional
Published: 2017
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28. DarkSide-20k: A 20 tonne two-phase LAr TPC for direct dark matter detection at LNGS

Author: Aalseth, C. E., Acerbi, F., Agnes, P., Albuquerque, I. F. M., Alexander, T., Alici, A., Alton, A. K., Antonioli, P., Arcelli, S., Ardito, R., Arnquist, I. J., Asner, D. M., Ave, M., Back, H. O., Barrado Olmedo, A. I., Batignani, G., Bertoldo, E., Bettarini, S., Bisogni, M. G., Bocci, V., Bondar, A., Bonfini, G., Bonivento, W., Bossa, M., Bottino, B., Boulay, M., Bunker, R., Bussino, S., Buzulutskov, A., Cadeddu, M., Cadoni, M., Caminata, A., Canci, N., Candela, A., Cantini, C., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Castellani, A., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Cereseto, R., Chepurnov, A., Cicalò, C., Cifarelli, L., Citterio, M., Cocco, A. G., Colocci, M., Corgiolu, S., Covone, G., Crivelli, P., D’Antone, I., D’Incecco, M., D’Urso, D., Da Rocha Rolo, M. D., Daniel, M., Davini, S., de Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Guido, G., De Rosa, G., Dellacasa, G., Della Valle, M., Demontis, P., Derbin, A., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Dolgov, A., Dormia, I., Dussoni, S., Empl, A., Fernandez Diaz, M., Ferri, A., Filip, C., Fiorillo, G., Fomenko, K., Franco, D., Froudakis, G. E., Gabriele, F., Gabrieli, A., Galbiati, C., Garcia Abia, P., Gendotti, A., Ghisi, A., Giagu, S., Giampa, P., Gibertoni, G., Giganti, C., Giorgi, M. A., Giovanetti, G. K., Gligan, M. L., Gola, A., Gorchakov, O., Goretti, A. M., Granato, F., Grassi, M., Grate, J. W., Grigoriev, G. Y., Gromov, M., Guan, M., Guerra, M. B. B., Guerzoni, M., Gulino, M., Haaland, R. K., Hallin, A., Harrop, B., Hoppe, E. W., Horikawa, S., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, An., Jillings, C., Johnson, T. N., Keeter, K., Kendziora, C. L., Kim, S., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., Kuźniak, M., La Commara, M., Lehnert, B., Li, X., Lissia, M., Lodi, G. U., Loer, B., Longo, G., Loverre, P., Lussana, R., Luzzi, L., Ma, Y., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Marcante, M., Margotti, A., Mari, S. M., Mariani, M., Maricic, J., Martoff, C. J., Mascia, M., Mayer, M., McDonald, A. B., Messina, A., Meyers, P. D., Milincic, R., Moggi, A., Moioli, S., Monroe, J., Monte, A., Morrocchi, M., Mount, B. J., Mu, W., Muratova, V. N., Murphy, S., Musico, P., Nania, R., Navrer Agasson, A., Nikulin, I., Nosov, V., Nozdrina, A. O., Nurakhov, N. N., Oleinik, A., Oleynikov, V., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Palmas, S., Pandola, L., Pantic, E., Paoloni, E., Paternoster, G., Pavletcov, V., Pazzona, F., Peeters, S., Pelczar, K., Pellegrini, L. A., Pelliccia, N., Perotti, F., Perruzza, R., Pesudo, V., Piemonte, C., Pilo, F., Pocar, A., Pollmann, T., Portaluppi, D., Pugachev, D. A., Qian, H., Radics, B., Raffaelli, F., Ragusa, F., Razeti, M., Razeto, A., Regazzoni, V., Regenfus, C., Reinhold, B., Renshaw, A. L., Rescigno, M., Retière, F., Riffard, Q., Rivetti, A., Rizzardini, S., Romani, A., Romero, L., Rossi, B., Rossi, N., Rubbia, A., Sablone, D., Salatino, P., Samoylov, O., Sánchez García, E., Sands, W., Sanfilippo, S., Sant, M., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Scioli, G., Segreto, E., Seifert, A., Semenov, D. A., Shchagin, A., Shekhtman, L., Shemyakina, E., Sheshukov, A., Simeone, M., Singh, P. N., Skensved, P., Skorokhvatov, M. D., Smirnov, O., Sobrero, G., Sokolov, A., Sotnikov, A., Speziale, F., Stainforth, R., Stanford, C., Suffritti, G. B., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Tosi, A., Trinchese, P., Unzhakov, E. V., Vacca, A., Vázquez-Jáuregui, E., Verducci, M., Viant, T., Villa, F., Vishneva, A., Vogelaar, B., Wada, M., Wahl, J., Walding, J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Williams, R., Wojcik, M. M., Wu, S., Xiang, X., Xiao, X., Yang, C., Ye, Z., Yllera de Llano, A., Zappa, F., Zappalà, G., Zhu, C., Zichichi, A., Zullo, M., Zullo, A., and Zuzel, G.
Published: 2018
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29. 499 A 15-Year Experience of Colorectal Pulmonary Metastasectomy in a High-Volume Tertiary Referral Centre

Author: Taylor, M, primary, Singhania, A, additional, Biswas, S, additional, Grant, S W, additional, Krysiak, P, additional, Fontaine, E, additional, Granato, F, additional, Joshi, V, additional, and Rammohan, K S, additional
Published: 2022
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30. Effective field theory interactions for liquid argon target in DarkSide-50 experiment

Author: Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Ave, M, Back, H, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cocco, A, Covone, G, D'Angelo, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, Derbin, A, Devoto, A, Di Eusanio, F, D'Incecco, M, Di Pietro, G, Dionisi, C, Downing, M, D'Urso, D, Edkins, E, Empl, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Galbiati, C, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Grobov, A, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, Johnson, T, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, La Commara, M, Lai, M, Li, X, Lissia, M, Longo, G, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Monte, A, Morrocchi, M, Muratova, V, Musico, P, Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pelczar, K, Pelliccia, N, Picciau, E, Pocar, A, Pordes, S, Poudel, S, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Savarese, C, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, R, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zuzel, G, Agnes P., Albuquerque I. F. M., Alexander T., Alton A. K., Ave M., Back H. O., Batignani G., Biery K., Bocci V., Bonfini G., Bonivento W. M., Bottino B., Bussino S., Cadeddu M., Cadoni M., Calaprice F., Caminata A., Canci N., Candela A., Caravati M., Cariello M., Carlini M., Carpinelli M., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Chepurnov A., Cicalo C., Cocco A. G., Covone G., D'Angelo D., Davini S., De Candia A., De Cecco S., De Deo M., De Filippis G., De Rosa G., Derbin A. V., Devoto A., Di Eusanio F., D'Incecco M., Di Pietro G., Dionisi C., Downing M., D'Urso D., Edkins E., Empl A., Fiorillo G., Fomenko K., Franco D., Gabriele F., Galbiati C., Ghiano C., Giagu S., Giganti C., Giovanetti G. K., Gorchakov O., Goretti A. M., Granato F., Grobov A., Gromov M., Guan M., Guardincerri Y., Gulino M., Hackett B. R., Herner K., Hosseini B., Hughes D., Humble P., Hungerford E. V., Ianni A., Ippolito V., Johnson T. N., Keeter K., Kendziora C. L., Kochanek I., Koh G., Korablev D., Korga G., Kubankin A., Kuss M., La Commara M., Lai M., Li X., Lissia M., Longo G., Machado A. A., Machulin I. N., Mandarano A., Mapelli L., Mari S. M., Maricic J., Martoff C. J., Messina A., Meyers P. D., Milincic R., Monte A., Morrocchi M., Muratova V. N., Musico P., Agasson A. N., Nozdrina A. O., Oleinik A., Orsini M., Ortica F., Pagani L., Pallavicini M., Pandola L., Pantic E., Paoloni E., Pelczar K., Pelliccia N., Picciau E., Pocar A., Pordes S., Poudel S. S., Qian H., Ragusa F., Razeti M., Razeto A., Renshaw A. L., Rescigno M., Riffard Q., Romani A., Rossi B., Rossi N., Sablone D., Samoylov O., Sands W., Sanfilippo S., Savarese C., Schlitzer B., Segreto E., Semenov D. A., Shchagin A., Sheshukov A., Singh P. N., Skorokhvatov M. D., Smirnov O., Sotnikov A., Stanford C., Stracka S., Suvorov Y., Tartaglia R., Testera G., Tonazzo A., Trinchese P., Unzhakov E. V., Verducci M., Vishneva A., Vogelaar R. B., Wada M., Waldrop T. J., Wang H., Wang Y., Watson A. W., Westerdale S., Wojcik M. M., Xiang X., Xiao X., Yang C., Ye Z., Zhu C., Zuzel G., Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Ave, M, Back, H, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cocco, A, Covone, G, D'Angelo, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, Derbin, A, Devoto, A, Di Eusanio, F, D'Incecco, M, Di Pietro, G, Dionisi, C, Downing, M, D'Urso, D, Edkins, E, Empl, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Galbiati, C, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Grobov, A, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, Johnson, T, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, La Commara, M, Lai, M, Li, X, Lissia, M, Longo, G, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Monte, A, Morrocchi, M, Muratova, V, Musico, P, Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pelczar, K, Pelliccia, N, Picciau, E, Pocar, A, Pordes, S, Poudel, S, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Savarese, C, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, R, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zuzel, G, Agnes P., Albuquerque I. F. M., Alexander T., Alton A. K., Ave M., Back H. O., Batignani G., Biery K., Bocci V., Bonfini G., Bonivento W. M., Bottino B., Bussino S., Cadeddu M., Cadoni M., Calaprice F., Caminata A., Canci N., Candela A., Caravati M., Cariello M., Carlini M., Carpinelli M., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Chepurnov A., Cicalo C., Cocco A. G., Covone G., D'Angelo D., Davini S., De Candia A., De Cecco S., De Deo M., De Filippis G., De Rosa G., Derbin A. V., Devoto A., Di Eusanio F., D'Incecco M., Di Pietro G., Dionisi C., Downing M., D'Urso D., Edkins E., Empl A., Fiorillo G., Fomenko K., Franco D., Gabriele F., Galbiati C., Ghiano C., Giagu S., Giganti C., Giovanetti G. K., Gorchakov O., Goretti A. M., Granato F., Grobov A., Gromov M., Guan M., Guardincerri Y., Gulino M., Hackett B. R., Herner K., Hosseini B., Hughes D., Humble P., Hungerford E. V., Ianni A., Ippolito V., Johnson T. N., Keeter K., Kendziora C. L., Kochanek I., Koh G., Korablev D., Korga G., Kubankin A., Kuss M., La Commara M., Lai M., Li X., Lissia M., Longo G., Machado A. A., Machulin I. N., Mandarano A., Mapelli L., Mari S. M., Maricic J., Martoff C. J., Messina A., Meyers P. D., Milincic R., Monte A., Morrocchi M., Muratova V. N., Musico P., Agasson A. N., Nozdrina A. O., Oleinik A., Orsini M., Ortica F., Pagani L., Pallavicini M., Pandola L., Pantic E., Paoloni E., Pelczar K., Pelliccia N., Picciau E., Pocar A., Pordes S., Poudel S. S., Qian H., Ragusa F., Razeti M., Razeto A., Renshaw A. L., Rescigno M., Riffard Q., Romani A., Rossi B., Rossi N., Sablone D., Samoylov O., Sands W., Sanfilippo S., Savarese C., Schlitzer B., Segreto E., Semenov D. A., Shchagin A., Sheshukov A., Singh P. N., Skorokhvatov M. D., Smirnov O., Sotnikov A., Stanford C., Stracka S., Suvorov Y., Tartaglia R., Testera G., Tonazzo A., Trinchese P., Unzhakov E. V., Verducci M., Vishneva A., Vogelaar R. B., Wada M., Waldrop T. J., Wang H., Wang Y., Watson A. W., Westerdale S., Wojcik M. M., Xiang X., Xiao X., Yang C., Ye Z., Zhu C., and Zuzel G.
Abstract: We reanalyze data collected with the DarkSide-50 experiment and recently used to set limits on the spinindependent interaction rate of weakly interacting massive particles (WIMPs) on argon nuclei with an effective field theory framework. The dataset corresponds to a total (16660 ± 270) kg d exposure using a target of low-radioactivity argon extracted from underground sources. We obtain upper limits on the effective couplings of the 12 leading operators in the nonrelativistic systematic expansion. For each effective coupling we set constraints on WIMP-nucleon cross sections, setting upper limits between 2.4 × 10-45 cm2 and 2.3 × 10-42 cm2 (8.9 × 10-45 cm2 and 6.0 × 10-42 cm2) for WIMPs of mass of 100 GeV=c2 (1000 GeV=c2) at 90% confidence level.
Published: 2020

31. Latest results of dark matter detection with the DarkSide experiment

Author: Picciau, E, Agnes, P, Albuquerque, I, Alton, A, Ave, M, Back, H, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cocco, A, Covone, G, D'Angelo, D, Davini, S, de Candia, A, de Cecco, S, de Deo, M, de Filippis, G, de Rosa, G, Derbin, A, Devoto, A, Di Eusanio, F, D'Incecco, M, Di Pietro, G, Dionisi, C, Downing, M, D'Urso, D, Edkins, E, Empl, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Galbiati, C, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Grobov, A, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, Johnson, T, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, la Commara, M, Lai, M, Li, X, Lissia, M, Longo, G, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Monte, A, Morrocchi, M, Muratova, V, Musico, P, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pelczar, K, Pelliccia, N, Pocar, A, Pordes, S, Poudel, S, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Savarese, C, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, R, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zuzel, G, Picciau E., Agnes P., Albuquerque I. F. M., Alton A. K., Ave M., Back H. O., Batignani G., Biery K., Bocci V., Bonfini G., Bonivento W. M., Bottino B., Bussino S., Cadeddu M., Cadoni M., Calaprice F., Caminata A., Canci N., Candela A., Caravati M., Cariello M., Carlini M., Carpinelli M., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Chepurnov A., Cicalo C., Cocco A. G., Covone G., D'Angelo D., Davini S., de Candia A., de Cecco S., de Deo M., de Filippis G., de Rosa G., Derbin A. V., Devoto A., Di Eusanio F., D'Incecco M., Di Pietro G., Dionisi C., Downing M., D'Urso D., Edkins E., Empl A., Fiorillo G., Fomenko K., Franco D., Gabriele F., Galbiati C., Ghiano C., Giagu S., Giganti C., Giovanetti G. K., Gorchakov O., Goretti A. M., Granato F., Grobov A., Gromov M., Guan M., Guardincerri Y., Gulino M., Hackett B. R., Herner K., Hosseini B., Hughes D., Humble P., Hungerford E. V., Ianni Al., Ianni An., Ippolito V., Johnson T. N., Keeter K., Kendziora C. L., Kochanek I., Koh G., Korablev D., Korga G., Kubankin A., Kuss M., la Commara M., Lai M., Li X., Lissia M., Longo G., Machado A. A., Machulin I. N., Mandarano A., Mapelli L., Mari S. M., Maricic J., Martoff C. J., Messina A., Meyers P. D., Milincic R., Monte A., Morrocchi M., Muratova V. N., Musico P., Navrer Agasson A., Nozdrina A. O., Oleinik A., Orsini M., Ortica F., Pagani L., Pallavicini M., Pandola L., Pantic E., Paoloni E., Pelczar K., Pelliccia N., Pocar A., Pordes S., Poudel S. S., Qian H., Ragusa F., Razeti M., Razeto A., Renshaw A. L., Rescigno M., Riffard Q., Romani A., Rossi B., Rossi N., Sablone D., Samoylov O., Sands W., Savarese C., Schlitzer B., Segreto E., Semenov D. A., Shchagin A., Sheshukov A., Singh P. N., Skorokhvatov M. D., Smirnov O., Sotnikov A., Stanford C., Stracka S., Suvorov Y., Tartaglia R., Testera G., Tonazzo A., Trinchese P., Unzhakov E. V., Verducci M., Vishneva A., Vogelaar R. B., Wada M., Waldrop T. J., Wang H., Wang Y., Watson A. W., Westerdale S., Wojcik M. M., Xiang X., Xiao X., Yang C., Ye Z., Zhu C., Zuzel G., Picciau, E, Agnes, P, Albuquerque, I, Alton, A, Ave, M, Back, H, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cocco, A, Covone, G, D'Angelo, D, Davini, S, de Candia, A, de Cecco, S, de Deo, M, de Filippis, G, de Rosa, G, Derbin, A, Devoto, A, Di Eusanio, F, D'Incecco, M, Di Pietro, G, Dionisi, C, Downing, M, D'Urso, D, Edkins, E, Empl, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Galbiati, C, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Grobov, A, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, Johnson, T, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, la Commara, M, Lai, M, Li, X, Lissia, M, Longo, G, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Monte, A, Morrocchi, M, Muratova, V, Musico, P, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pelczar, K, Pelliccia, N, Pocar, A, Pordes, S, Poudel, S, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Savarese, C, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, R, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zuzel, G, Picciau E., Agnes P., Albuquerque I. F. M., Alton A. K., Ave M., Back H. O., Batignani G., Biery K., Bocci V., Bonfini G., Bonivento W. M., Bottino B., Bussino S., Cadeddu M., Cadoni M., Calaprice F., Caminata A., Canci N., Candela A., Caravati M., Cariello M., Carlini M., Carpinelli M., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Chepurnov A., Cicalo C., Cocco A. G., Covone G., D'Angelo D., Davini S., de Candia A., de Cecco S., de Deo M., de Filippis G., de Rosa G., Derbin A. V., Devoto A., Di Eusanio F., D'Incecco M., Di Pietro G., Dionisi C., Downing M., D'Urso D., Edkins E., Empl A., Fiorillo G., Fomenko K., Franco D., Gabriele F., Galbiati C., Ghiano C., Giagu S., Giganti C., Giovanetti G. K., Gorchakov O., Goretti A. M., Granato F., Grobov A., Gromov M., Guan M., Guardincerri Y., Gulino M., Hackett B. R., Herner K., Hosseini B., Hughes D., Humble P., Hungerford E. V., Ianni Al., Ianni An., Ippolito V., Johnson T. N., Keeter K., Kendziora C. L., Kochanek I., Koh G., Korablev D., Korga G., Kubankin A., Kuss M., la Commara M., Lai M., Li X., Lissia M., Longo G., Machado A. A., Machulin I. N., Mandarano A., Mapelli L., Mari S. M., Maricic J., Martoff C. J., Messina A., Meyers P. D., Milincic R., Monte A., Morrocchi M., Muratova V. N., Musico P., Navrer Agasson A., Nozdrina A. O., Oleinik A., Orsini M., Ortica F., Pagani L., Pallavicini M., Pandola L., Pantic E., Paoloni E., Pelczar K., Pelliccia N., Pocar A., Pordes S., Poudel S. S., Qian H., Ragusa F., Razeti M., Razeto A., Renshaw A. L., Rescigno M., Riffard Q., Romani A., Rossi B., Rossi N., Sablone D., Samoylov O., Sands W., Savarese C., Schlitzer B., Segreto E., Semenov D. A., Shchagin A., Sheshukov A., Singh P. N., Skorokhvatov M. D., Smirnov O., Sotnikov A., Stanford C., Stracka S., Suvorov Y., Tartaglia R., Testera G., Tonazzo A., Trinchese P., Unzhakov E. V., Verducci M., Vishneva A., Vogelaar R. B., Wada M., Waldrop T. J., Wang H., Wang Y., Watson A. W., Westerdale S., Wojcik M. M., Xiang X., Xiao X., Yang C., Ye Z., Zhu C., and Zuzel G.
Abstract: In this contribution the latest results of dark matter direct detection obtained by the DarkSide Collaboration are discussed. New limits on the scattering cross-section between dark matter particles and baryonic matter have been set. The results have been reached using the DarkSide-50 detector, a double-phase Time Projection Chamber (TPC) filled with 40Ar and installed at Laboratori Nazionali del Gran Sasso (LNGS). In 2018, the DarkSide Collaboration has performed three different types of analysis. The so-called high-mass analysis into the range between ∼ 10 GeV and ∼ 1000 GeV is discussed under the hypothesis of scattering between dark matter and Ar nuclei. The low-mass analysis, performed using the same hypothesis, extends the limit down to ∼1.8 GeV. Through a different hypothesis, that predicts dark matter scattering off the electrons inside of the Ar atom, it has been possible to set limits for sub-GeV dark matter masses.
Published: 2020

32. Latest results of dark matter detection with the DarkSide experiment

Author: Picciau E., Agnes P., Albuquerque I. F. M., Alton A. K., Ave M., Back H. O., Batignani G., Biery K., Bocci V., Bonfini G., Bonivento W. M., Bottino B., Bussino S., Cadeddu M., Cadoni M., Calaprice F., Caminata A., Canci N., Candela A., Caravati M., Cariello M., Carlini M., Carpinelli M., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Chepurnov A., Cicalo C., Cocco A. G., Covone G., D'Angelo D., Davini S., de Candia A., de Cecco S., de Deo M., de Filippis G., de Rosa G., Derbin A. V., Devoto A., Di Eusanio F., D'Incecco M., Di Pietro G., Dionisi C., Downing M., D'Urso D., Edkins E., Empl A., Fiorillo G., Fomenko K., Franco D., Gabriele F., Galbiati C., Ghiano C., Giagu S., Giganti C., Giovanetti G. K., Gorchakov O., Goretti A. M., Granato F., Grobov A., Gromov M., Guan M., Guardincerri Y., Gulino M., Hackett B. R., Herner K., Hosseini B., Hughes D., Humble P., Hungerford E. V., Ianni Al., Ianni An., Ippolito V., Johnson T. N., Keeter K., Kendziora C. L., Kochanek I., Koh G., Korablev D., Korga G., Kubankin A., Kuss M., la Commara M., Lai M., Li X., Lissia M., Longo G., Machado A. A., Machulin I. N., Mandarano A., Mapelli L., Mari S. M., Maricic J., Martoff C. J., Messina A., Meyers P. D., Milincic R., Monte A., Morrocchi M., Muratova V. N., Musico P., Navrer Agasson A., Nozdrina A. O., Oleinik A., Orsini M., Ortica F., Pagani L., Pallavicini M., Pandola L., Pantic E., Paoloni E., Pelczar K., Pelliccia N., Pocar A., Pordes S., Poudel S. S., Qian H., Ragusa F., Razeti M., Razeto A., Renshaw A. L., Rescigno M., Riffard Q., Romani A., Rossi B., Rossi N., Sablone D., Samoylov O., Sands W., Savarese C., Schlitzer B., Segreto E., Semenov D. A., Shchagin A., Sheshukov A., Singh P. N., Skorokhvatov M. D., Smirnov O., Sotnikov A., Stanford C., Stracka S., Suvorov Y., Tartaglia R., Testera G., Tonazzo A., Trinchese P., Unzhakov E. V., Verducci M., Vishneva A., Vogelaar R. B., Wada M., Waldrop T. J., Wang H., Wang Y., Watson A. W., Westerdale S., Wojcik M. M., Xiang X., Xiao X., Yang C., Ye Z., Zhu C., Zuzel G., Picciau, E, Agnes, P, Albuquerque, I, Alton, A, Ave, M, Back, H, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cocco, A, Covone, G, D'Angelo, D, Davini, S, de Candia, A, de Cecco, S, de Deo, M, de Filippis, G, de Rosa, G, Derbin, A, Devoto, A, Di Eusanio, F, D'Incecco, M, Di Pietro, G, Dionisi, C, Downing, M, D'Urso, D, Edkins, E, Empl, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Galbiati, C, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Grobov, A, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, Johnson, T, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, la Commara, M, Lai, M, Li, X, Lissia, M, Longo, G, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Monte, A, Morrocchi, M, Muratova, V, Musico, P, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pelczar, K, Pelliccia, N, Pocar, A, Pordes, S, Poudel, S, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Savarese, C, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, R, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zuzel, G, Picciau, E., Agnes, P., Albuquerque, I. F. M., Alton, A. K., Ave, M., Back, H. O., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W. M., Bottino, B., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Chepurnov, A., Cicalo, C., Cocco, A. G., Covone, G., D'Angelo, D., Davini, S., de Candia, A., de Cecco, S., de Deo, M., de Filippis, G., de Rosa, G., Derbin, A. V., Devoto, A., Di Eusanio, F., D'Incecco, M., Di Pietro, G., Dionisi, C., Downing, M., D'Urso, D., Edkins, E., Empl, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Galbiati, C., Ghiano, C., Giagu, S., Giganti, C., Giovanetti, G. K., Gorchakov, O., Goretti, A. M., Granato, F., Grobov, A., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B. R., Herner, K., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, Al., Ianni, An., Ippolito, V., Johnson, T. N., Keeter, K., Kendziora, C. L., Kochanek, I., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., la Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Mari, S. M., Maricic, J., Martoff, C. J., Messina, A., Meyers, P. D., Milincic, R., Monte, A., Morrocchi, M., Muratova, V. N., Musico, P., Navrer Agasson, A., Nozdrina, A. O., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Pocar, A., Pordes, S., Poudel, S. S., Qian, H., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Savarese, C., Schlitzer, B., Segreto, E., Semenov, D. A., Shchagin, A., Sheshukov, A., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, R. B., Wada, M., Waldrop, T. J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., and Zuzel, G.
Subjects: Physic, High Energy Physics::Experiment, Nuclear Experiment
Abstract: In this contribution the latest results of dark matter direct detection obtained by the DarkSide Collaboration are discussed. New limits on the scattering cross-section between dark matter particles and baryonic matter have been set. The results have been reached using the DarkSide-50 detector, a double-phase Time Projection Chamber (TPC) filled with 40Ar and installed at Laboratori Nazionali del Gran Sasso (LNGS). In 2018, the DarkSide Collaboration has performed three different types of analysis. The so-called high-mass analysis into the range between ∼ 10 GeV and ∼ 1000 GeV is discussed under the hypothesis of scattering between dark matter and Ar nuclei. The low-mass analysis, performed using the same hypothesis, extends the limit down to ∼1.8 GeV. Through a different hypothesis, that predicts dark matter scattering off the electrons inside of the Ar atom, it has been possible to set limits for sub-GeV dark matter masses.
Published: 2020

33. DarkSide status and prospects

Author: Sanfilippo, S, Agnes, P, M Albuquerque, I, Alexander, T, Alton, A, Asner, D, Ave, M, Back, H, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Budano, F, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cardenas, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cifarelli, L, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, De Vincenzi, M, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Edkins, E, Empl, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Galbiati, C, Garcia Abia, P, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Herner, K, Horikawa, S, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, James, I, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, La Commara, M, Lai, M, Li, X, Lissia, M, Longo, G, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Jmartoff, C, Messina, A, Meyers, P, Milincic, R, Monte, A, Morrocchi, M, Muratova, V, Musico, P, Nania, R, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pelczar, K, Pelliccia, N, Pesudo, V, Picciau, E, Pocar, A, Pordes, S, Poudel, S, Pugachev, D, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Santorelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Simeone, M, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zuzel, G, Sanfilippo S., Agnes P., M Albuquerque I. F., Alexander T., Alton A. K., Asner D. M., Ave M. P., Back H. O., Batignani G., Biery K., Bocci V., Bonfini G., Bonivento W., Bottino B., Budano F., Bussino S., Cadeddu M., Cadoni M., Calaprice F., Caminata A., Canci N., Candela A., Caravati M., Cardenas M. M., Cariello M., Carlini M., Carpinelli M., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Chepurnov A., Cicalo C., Cifarelli L., Cocco A. G., Covone G., D'Angelo D., D'Incecco M., D'Urso D., Davini S., De Candia A., De Cecco S., De Deo M., De Filippis G., De Rosa G., De Vincenzi M., Derbin A. V., Devoto A., Di Eusanio F., Di Pietro G., Dionisi C., Edkins E., Empl A., Fiorillo G., Fomenko K., Franco D., Gabriele F., Galbiati C., Garcia Abia P., Ghiano C., Giagu S., Giganti C., Giovanetti G. K., Gorchakov O., Goretti A. M., Granato F., Gromov M., Guan M., Guardincerri Y., Gulino M., Hackett B. R., Herner K., Horikawa S., Hosseini B., Hughes D., Humble P., Hungerford E. V., Ianni An., Ippolito V., James I., Keeter K., Kendziora C. L., Kochanek I., Koh G., Korablev D., Korga G., Kubankin A., Kuss M., La Commara M., Lai M., Li X., Lissia M., Longo G., MacHado A. A., MacHulin I. N., Mandarano A., Mapelli L., Mari S. M., Maricic J., JMartoff C., Messina A., Meyers P. D., Milincic R., Monte A., Morrocchi M., Muratova V. N., Musico P., Nania R., Navrer Agasson A., Nozdrina A. O., Oleinik A., Orsini M., Ortica F., Pagani L., Pallavicini M., Pandola L., Pantic E., Paoloni E., Pelczar K., Pelliccia N., Pesudo V., Picciau E., Pocar A., Pordes S., Poudel S. S., Pugachev D. A., Qian H., Ragusa F., Razeti M., Razeto A., Renshaw A. L., Rescigno M., Riffard Q., Romani A., Rossi B., Rossi N., Sablone D., Samoylov O., Sands W., Santorelli R., Savarese C., Scapparone E., Schlitzer B., Segreto E., Semenov D. A., Shchagin A., Sheshukov A., Simeone M., Singh P. N., Skorokhvatov M. D., Smirnov O., Sotnikov A., Stanford C., Stracka S., Suvorov Y., Tartaglia R., Testera G., Tonazzo A., Trinchese P., Unzhakov E. V., Verducci M., Vishneva A., Vogelaar B., Wada M., Waldrop T. J., Wang H., Wang Y., Watson A. W., Westerdale S., Wojcik M. M., Xiang X., Xiao X., Yang C., Ye Z., Zhu C., Zuzel G., Sanfilippo, S, Agnes, P, M Albuquerque, I, Alexander, T, Alton, A, Asner, D, Ave, M, Back, H, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Budano, F, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cardenas, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cifarelli, L, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, De Vincenzi, M, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Edkins, E, Empl, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Galbiati, C, Garcia Abia, P, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Herner, K, Horikawa, S, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, James, I, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, La Commara, M, Lai, M, Li, X, Lissia, M, Longo, G, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Jmartoff, C, Messina, A, Meyers, P, Milincic, R, Monte, A, Morrocchi, M, Muratova, V, Musico, P, Nania, R, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pelczar, K, Pelliccia, N, Pesudo, V, Picciau, E, Pocar, A, Pordes, S, Poudel, S, Pugachev, D, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Santorelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Simeone, M, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zuzel, G, Sanfilippo S., Agnes P., M Albuquerque I. F., Alexander T., Alton A. K., Asner D. M., Ave M. P., Back H. O., Batignani G., Biery K., Bocci V., Bonfini G., Bonivento W., Bottino B., Budano F., Bussino S., Cadeddu M., Cadoni M., Calaprice F., Caminata A., Canci N., Candela A., Caravati M., Cardenas M. M., Cariello M., Carlini M., Carpinelli M., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Chepurnov A., Cicalo C., Cifarelli L., Cocco A. G., Covone G., D'Angelo D., D'Incecco M., D'Urso D., Davini S., De Candia A., De Cecco S., De Deo M., De Filippis G., De Rosa G., De Vincenzi M., Derbin A. V., Devoto A., Di Eusanio F., Di Pietro G., Dionisi C., Edkins E., Empl A., Fiorillo G., Fomenko K., Franco D., Gabriele F., Galbiati C., Garcia Abia P., Ghiano C., Giagu S., Giganti C., Giovanetti G. K., Gorchakov O., Goretti A. M., Granato F., Gromov M., Guan M., Guardincerri Y., Gulino M., Hackett B. R., Herner K., Horikawa S., Hosseini B., Hughes D., Humble P., Hungerford E. V., Ianni An., Ippolito V., James I., Keeter K., Kendziora C. L., Kochanek I., Koh G., Korablev D., Korga G., Kubankin A., Kuss M., La Commara M., Lai M., Li X., Lissia M., Longo G., MacHado A. A., MacHulin I. N., Mandarano A., Mapelli L., Mari S. M., Maricic J., JMartoff C., Messina A., Meyers P. D., Milincic R., Monte A., Morrocchi M., Muratova V. N., Musico P., Nania R., Navrer Agasson A., Nozdrina A. O., Oleinik A., Orsini M., Ortica F., Pagani L., Pallavicini M., Pandola L., Pantic E., Paoloni E., Pelczar K., Pelliccia N., Pesudo V., Picciau E., Pocar A., Pordes S., Poudel S. S., Pugachev D. A., Qian H., Ragusa F., Razeti M., Razeto A., Renshaw A. L., Rescigno M., Riffard Q., Romani A., Rossi B., Rossi N., Sablone D., Samoylov O., Sands W., Santorelli R., Savarese C., Scapparone E., Schlitzer B., Segreto E., Semenov D. A., Shchagin A., Sheshukov A., Simeone M., Singh P. N., Skorokhvatov M. D., Smirnov O., Sotnikov A., Stanford C., Stracka S., Suvorov Y., Tartaglia R., Testera G., Tonazzo A., Trinchese P., Unzhakov E. V., Verducci M., Vishneva A., Vogelaar B., Wada M., Waldrop T. J., Wang H., Wang Y., Watson A. W., Westerdale S., Wojcik M. M., Xiang X., Xiao X., Yang C., Ye Z., Zhu C., and Zuzel G.
Abstract: DarkSide uses a dual-phase Liquid Argon Time Projection Chamber to search for WIMP dark matter. The current detector, DarkSide-50, is running since mid 2015 with a target of 50 kg of Argon from an underground source. Here it is presented the latest results of searches of WIMP-nucleus interactions, with WIMP masses in the GeV-TeV range, and of WIMP-electron interactions, in the sub-GeV mass range. The future of DarkSide with a new generation experiment, involving a global collaboration from all the current Argon based experiments, is presented.
Published: 2019

34. DarkSide: Latest results and future perspectives

Author: Bottino, B, Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Asner, D, Ave, M, Back, H, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cardenas, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cifarelli, L, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, De Vincenzi, M, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Edkins, E, Empl, A, Fan, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Galbiati, C, Garcia Abia, P, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, James, I, Johnson, T, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, La Commara, M, Lai, M, Li, X, Lissia, M, Longo, G, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Monte, A, Morrocchi, M, Mount, B, Muratova, V, Musico, P, Nania, R, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pelczar, K, Pelliccia, N, Pesudo, V, Pocar, A, Pordes, S, Poudel, S, Pugachev, D, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Santorelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Simeone, M, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zuzel, G, Bottino B., Agnes P., Albuquerque I. F. M., Alexander T., Alton A. K., Asner D. M., Ave MP., Back H. O., Batignani G., Biery K., Bocci V., Bonfini G., Bonivento W., Bussino S., Cadeddu M., Cadoni M., Calaprice F., Caminata A., Canci N., Candela A., Caravati M., Cardenas M. M., Cariello M., Carlini M., Carpinelli M., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Chepurnov A., Cicalo C., Cifarelli L., Cocco A. G., Covone G., D'Angelo D., D'Incecco M., D'Urso D., Davini S., De Candia A., De Cecco S., De Deo M., De Filippis G., De Rosa G., De Vincenzi M., Derbin A. V., Devoto A., Di Eusanio F., Di Pietro G., Dionisi C., Edkins E., Empl A., Fan A., Fiorillo G., Fomenko K., Franco D., Gabriele F., Galbiati C., Garcia Abia P., Ghiano C., Giagu S., Giganti C., Giovanetti G. K., Gorchakov O., Goretti A. M., Granato F., Gromov M., Guan M., Guardincerri Y., Gulino M., Hackett B. R., Herner K., Hosseini B., Hughes D., Humble P., Hungerford E. V., Ianni An., Ippolito V., James I., Johnson T. N., Keeter K., Kendziora C. L., Kochanek I., Koh G., Korablev D., Korga G., Kubankin A., Kuss M., La Commara M., Lai M., Li X., Lissia M., Longo G., MacHado A. A., MacHulin I. N., Mandarano A., Mapelli L., Mari S. M., Maricic J., Martoff C. J., Messina A., Meyers P. D., Milincic R., Monte A., Morrocchi M., Mount B. J., Muratova V. N., Musico P., Nania R., Navrer Agasson A., Nozdrina A. O., Oleinik A., Orsini M., Ortica F., Pagani L., Pallavicini M., Pandola L., Pantic E., Paoloni E., Pelczar K., Pelliccia N., Pesudo V., Pocar A., Pordes S., Poudel S. S., Pugachev D. A., Qian H., Ragusa F., Razeti M., Razeto A., Renshaw A. L., Rescigno M., Riffard Q., Romani A., Rossi B., Rossi N., Sablone D., Samoylov O., Sands W., Sanfilippo S., Santorelli R., Savarese C., Scapparone E., Schlitzer B., Segreto E., Semenov D. A., Shchagin A., Sheshukov A., Simeone M., Singh P. N., Skorokhvatov M. D., Smirnov O., Sotnikov A., Stanford C., Stracka S., Suvorov Y., Tartaglia R., Testera G., Tonazzo A., Trinchese P., Unzhakov E. V., Verducci M., Vishneva A., Vogelaar B., Wada M., Waldrop T. J., Wang H., Wang Y., Watson A. W., Westerdale S., Wojcik M. M., Xiang X., Xiao X., Yang C., Ye Z., Zhu C., Zuzel G., Bottino, B, Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Asner, D, Ave, M, Back, H, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cardenas, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cifarelli, L, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, De Vincenzi, M, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Edkins, E, Empl, A, Fan, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Galbiati, C, Garcia Abia, P, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, James, I, Johnson, T, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, La Commara, M, Lai, M, Li, X, Lissia, M, Longo, G, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Monte, A, Morrocchi, M, Mount, B, Muratova, V, Musico, P, Nania, R, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pelczar, K, Pelliccia, N, Pesudo, V, Pocar, A, Pordes, S, Poudel, S, Pugachev, D, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Santorelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Simeone, M, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zuzel, G, Bottino B., Agnes P., Albuquerque I. F. M., Alexander T., Alton A. K., Asner D. M., Ave MP., Back H. O., Batignani G., Biery K., Bocci V., Bonfini G., Bonivento W., Bussino S., Cadeddu M., Cadoni M., Calaprice F., Caminata A., Canci N., Candela A., Caravati M., Cardenas M. M., Cariello M., Carlini M., Carpinelli M., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Chepurnov A., Cicalo C., Cifarelli L., Cocco A. G., Covone G., D'Angelo D., D'Incecco M., D'Urso D., Davini S., De Candia A., De Cecco S., De Deo M., De Filippis G., De Rosa G., De Vincenzi M., Derbin A. V., Devoto A., Di Eusanio F., Di Pietro G., Dionisi C., Edkins E., Empl A., Fan A., Fiorillo G., Fomenko K., Franco D., Gabriele F., Galbiati C., Garcia Abia P., Ghiano C., Giagu S., Giganti C., Giovanetti G. K., Gorchakov O., Goretti A. M., Granato F., Gromov M., Guan M., Guardincerri Y., Gulino M., Hackett B. R., Herner K., Hosseini B., Hughes D., Humble P., Hungerford E. V., Ianni An., Ippolito V., James I., Johnson T. N., Keeter K., Kendziora C. L., Kochanek I., Koh G., Korablev D., Korga G., Kubankin A., Kuss M., La Commara M., Lai M., Li X., Lissia M., Longo G., MacHado A. A., MacHulin I. N., Mandarano A., Mapelli L., Mari S. M., Maricic J., Martoff C. J., Messina A., Meyers P. D., Milincic R., Monte A., Morrocchi M., Mount B. J., Muratova V. N., Musico P., Nania R., Navrer Agasson A., Nozdrina A. O., Oleinik A., Orsini M., Ortica F., Pagani L., Pallavicini M., Pandola L., Pantic E., Paoloni E., Pelczar K., Pelliccia N., Pesudo V., Pocar A., Pordes S., Poudel S. S., Pugachev D. A., Qian H., Ragusa F., Razeti M., Razeto A., Renshaw A. L., Rescigno M., Riffard Q., Romani A., Rossi B., Rossi N., Sablone D., Samoylov O., Sands W., Sanfilippo S., Santorelli R., Savarese C., Scapparone E., Schlitzer B., Segreto E., Semenov D. A., Shchagin A., Sheshukov A., Simeone M., Singh P. N., Skorokhvatov M. D., Smirnov O., Sotnikov A., Stanford C., Stracka S., Suvorov Y., Tartaglia R., Testera G., Tonazzo A., Trinchese P., Unzhakov E. V., Verducci M., Vishneva A., Vogelaar B., Wada M., Waldrop T. J., Wang H., Wang Y., Watson A. W., Westerdale S., Wojcik M. M., Xiang X., Xiao X., Yang C., Ye Z., Zhu C., and Zuzel G.
Abstract: DarkSide is direct-detection dark-matter experimental project based on radiopure argon. The main goal of the DarkSide program is the detection of rare nuclear elastic collisions with hypothetical dark-matter particles. The present detector, DarkSide-50, placed at Laboratori Nazionali del Gran Sasso (LNGS), is a dualphase time projection chamber (TPC) filled with ultra-pure liquid argon, extracted from underground sources. Surrounding the TPC to suppress the background there are neutron and muon active vetoes. One of argon key features is the capability to distinguish between electron and nuclear recoils, exploiting the different shapes of the signals. DarkSide-50 new results, obtained using a live-days exposure of 532.4 days, are presented. This analysis sets a 90% C.L. upper limit on the dark matternucleon spin-independent cross-section of 1.1 × 10-44 cm2 for a WIMP mass of 100 GeV/c2. The next phase of the project, DarkSide-20k, will be a new detector with a fiducial mass of ∼ 20 tons, equipped with cryogenic silicon photomultipliers (SiPM).
Published: 2019

35. DarkSide-50 results and the future liquid argon dark matter program

Author: Caminata, A, Aalseth, C, Abdelhakim, S, Acerbi, F, Agnes, P, Albuquerque, I, Alexander, T, Alici, A, Alton, A, Amaudruz, P, Ameli, F, Antonioli, P, Arcelli, S, Ardito, R, Arnquist, I, Arpaia, P, Asner, D, Asunskis, A, Ave, M, Back, H, Barrado Olmedo, A, Batignani, G, Bisogni, M, Bocci, V, Bondar, A, Bonfini, G, Bonivento, W, Bottino, B, Boulay, M, Bunker, R, Bussino, S, Buzulutskov, A, Cadeddu, M, Cadoni, M, Canci, N, Candela, A, Cantini, C, Caravati, M, Cariello, M, Carpinelli, M, Castellani, A, Castello, P, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Cebrian, S, Celano, B, Cereseto, R, Cheng, W, Chepurnov, A, Cicalo, C, Ci-Farelli, L, Citterio, M, Cocco, A, Colocci, M, Consiglio, L, Cossio, F, Covone, G, Crivelli, P, D'Antone, I, D'Incecco, M, D'Urso, D, da Rocha Rolo, M, Daniel, M, Davini, S, de Candia, A, de Cecco, S, de Deo, M, de Falco, A, de Filippis, G, de Gruttola, D, de Guido, G, de Rosa, G, Dellacasa, G, Demontis, P, Depaquale, S, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Di Stefano, P, Dionisi, C, Dordei, F, Downing, M, Edalatfar, F, Empl, A, Fernandez Diaz, M, Ferri, A, Filip, C, Fiorillo, G, Fomenko, K, Franceschi, A, Franco, D, Froudakis, G, Gabriele, F, Gabrieli, A, Gal-Biati, C, Garcia Abia, P, Gascon Fora, D, Gendotti, A, Ghiano, C, Ghisi, A, Giagu, S, Giampa, P, Giampaolo, R, Giganti, C, Giorgi, M, Giovanetti, G, Gligan, M, Gola, A, Gorchakov, O, Grab, M, Graciani Diaz, R, Granato, F, Grassi, M, Grate, J, Grigoriev, G, Grobov, A, Gromov, M, Guan, M, Guerra, M, Guerzoni, M, Gulino, M, Haaland, R, Hackett, B, Hallin, A, Harrop, B, Hoppe, E, Horikawa, S, Hosseini, B, Hubaut, F, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, Jillings, C, Jimenez Cabre, S, Keeter, K, Kendziora, C, Kim, S, Kochanek, I, Kondo, K, Kopp, G, Korablev, D, Korga, G, Kubankin, A, Kugathasan, R, Kuss, M, Kuzniak, M, la Commara, M, Lai, M, Langrock, S, Lebois, M, Lehnert, B, Li, X, Liqiang, Q, Lissia, M, Lodi, G, Longo, G, Lussana, R, Luzzi, L, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Marcante, M, Margotti, A, Mari, S, Mariani, M, Maricic, J, Marinelli, M, Marras, D, Martinez Rojas, A, Martoff, C, Mascia, M, Masoni, A, Mazzi, A, Mcdonald, A, Messina, A, Meyers, P, Miletic, T, Milincic, R, Moggi, A, Moioli, S, Monroe, J, Morrocchi, M, Mroz, T, Mu, W, Muratova, V, Murphy, S, Muscas, C, Musico, P, Nania, R, Napolitano, T, Navrer Agasson, A, Nessi, M, Nikulin, I, Nozdrina, A, Nurakhov, N, Oleinik, A, Oleynikov, V, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pal-Mas, S, Pandola, L, Pantic, E, Paoloni, E, Paternoster, G, Pavletcov, V, Pazzona, F, Peeters, S, Pegoraro, P, Pelczar, K, Pellegrini, L, Pelliccia, N, Perotti, F, Pesudo, V, Picciau, E, Piemonte, C, Pietropaolo, F, Pocar, A, Pollman, T, Portaluppi, D, Poudel, S, Price, D, Pugachev, D, Radics, B, Raffaelli, F, Ragusa, F, Razeti, M, Razeto, A, Regazzoni, V, Regenfus, C, Renshaw, A, Rescia, S, Rescigno, M, Retiere, F, Riffard, Q, Rivetti, A, Romani, A, Romero, L, Rossi, N, Rubbia, A, Sablone, D, Sala, P, Salatino, P, Samoylov, O, Sanchez Garcia, E, Sanfilippo, S, Sant, M, Santone, D, San-Torelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Scioli, G, Segreto, E, Seifert, A, Semenov, D, Shchagin, A, She-Myakina, E, Sheshukov, A, Siddhanta, S, Simeone, M, Singh, P, Skensved, P, Skorokhvatov, M, Smirnov, O, So-Brero, G, Sokolov, A, Sotnikov, A, Stainforth, R, Stracka, S, Suffritti, G, Sulis, S, Suvorov, Y, Szelc, A, Tartaglia, R, Testera, G, Thorpe, T, Tonazzo, A, Tosi, A, Unzhakov, E, Usai, G, Vacca, A, Vazquez-Jauregui, E, Verducci, M, Viant, T, Viel, S, Villa, F, Vishneva, A, Vogelaar, R, Wada, M, Wahl, J, Walding, J, Wang, H, Wang, Y, Westerdale, S, Wheadon, R, Williams, R, Wilson, J, Wojcik, M, Wu, S, Xiao, X, Yang, C, Ye, Z, Zuzel, G, Caminata A., Aalseth C. E., Abdelhakim S., Acerbi F., Agnes P., Albuquerque I. F. M., Alexander T., Alici A., Alton A. K., Amaudruz P., Ameli F., Antonioli P., Arcelli S., Ardito R., Arnquist I. J., Arpaia P., Asner D. M., Asunskis A., Ave M., Back H. O., Barrado Olmedo A., Batignani G., Bisogni M. G., Bocci V., Bondar A., Bonfini G., Bonivento W., Bottino B., Boulay M. G., Bunker R., Bussino S., Buzulutskov A., Cadeddu M., Cadoni M., Canci N., Candela A., Cantini C., Caravati M., Cariello M., Carpinelli M., Castellani A., Castello P., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Cebrian S., Celano B., Cereseto R., Cheng W., Chepurnov A., Cicalo C., Ci-Farelli L., Citterio M., Cocco A. G., Colocci M., Consiglio L., Cossio F., Covone G., Crivelli P., D'Antone I., D'Incecco M., D'Urso D., da Rocha Rolo M. D., Daniel M., Davini S., de Candia A., de Cecco S., de Deo M., de Falco A., de Filippis G., de Gruttola D., de Guido G., de Rosa G., Dellacasa G., Demontis P., DePaquale S., Derbin A. V., Devoto A., Di Eusanio F., Di Pietro G., Di Stefano P., Dionisi C., Dordei F., Downing M., Edalatfar F., Empl A., Fernandez Diaz M., Ferri A., Filip C., Fiorillo G., Fomenko K., Franceschi A., Franco D., Froudakis G. E., Gabriele F., Gabrieli A., Gal-Biati C., Garcia Abia P., Gascon Fora D., Gendotti A., Ghiano C., Ghisi A., Giagu S., Giampa P., Giampaolo R. A., Giganti C., Giorgi M. A., Giovanetti G. K., Gligan M. L., Gola A., Gorchakov O., Grab M., Graciani Diaz R., Granato F., Grassi M., Grate J. W., Grigoriev G. Y., Grobov A., Gromov M., Guan M., Guerra M. B. B., Guerzoni M., Gulino M., Haaland R. K., Hackett B. R., Hallin A., Harrop B., Hoppe E. W., Horikawa S., Hosseini B., Hubaut F., Humble P., Hungerford E. V., Ianni An., Ippolito V., Jillings C., Jimenez Cabre S., Keeter K., Kendziora C. L., Kim S., Kochanek I., Kondo K., Kopp G., Korablev D., Korga G., Kubankin A., Kugathasan R., Kuss M., Kuzniak M., la Commara M., Lai M., Langrock S., Lebois M., Lehnert B., Li X., Liqiang Q., Lissia M., Lodi G. U., Longo G., Lussana R., Luzzi L., Machado A. A., Machulin I. N., Mandarano A., Mapelli L., Marcante M., Margotti A., Mari S. M., Mariani M., Maricic J., Marinelli M., Marras D., Martinez Rojas A. D., Martoff C. J., Mascia M., Masoni A., Mazzi A., McDonald A. B., Messina A., Meyers P. D., Miletic T., Milincic R., Moggi A., Moioli S., Monroe J., Morrocchi M., Mroz T., Mu W., Muratova V. N., Murphy S., Muscas C., Musico P., Nania R., Napolitano T., Navrer Agasson A., Nessi M., Nikulin I., Nozdrina A. O., Nurakhov N. N., Oleinik A., Oleynikov V., Orsini M., Ortica F., Pagani L., Pallavicini M., Pal-Mas S., Pandola L., Pantic E., Paoloni E., Paternoster G., Pavletcov V., Pazzona F., Peeters S., Pegoraro P. A., Pelczar K., Pellegrini L. A., Pelliccia N., Perotti F., Pesudo V., Picciau E., Piemonte C., Pietropaolo F., Pocar A., Pollman T., Portaluppi D., Poudel S. S., Price D., Pugachev D. A., Radics B., Raffaelli F., Ragusa F., Razeti M., Razeto A., Regazzoni V., Regenfus C., Renshaw A. L., Rescia S., Rescigno M., Retiere F., Riffard Q., Rivetti A., Romani A., Romero L., Rossi N., Rubbia A., Sablone D., Sala P., Salatino P., Samoylov O., Sanchez Garcia E., Sanfilippo S., Sant M., Santone D., San-Torelli R., Savarese C., Scapparone E., Schlitzer B., Scioli G., Segreto E., Seifert A., Semenov D. A., Shchagin A., She-Myakina E., Sheshukov A., Siddhanta S., Simeone M., Singh P. N., Skensved P., Skorokhvatov M. D., Smirnov O., So-Brero G., Sokolov A., Sotnikov A., Stainforth R., Stracka S., Suffritti G. B., Sulis S., Suvorov Y., Szelc A. M., Tartaglia R., Testera G., Thorpe T., Tonazzo A., Tosi A., Unzhakov E. V., Usai G., Vacca A., Vazquez-Jauregui E., Verducci M., Viant T., Viel S., Villa F., Vishneva A., Vogelaar R. B., Wada M., Wahl J., Walding J. J., Wang H., Wang Y., Westerdale S., Wheadon R. J., Williams R., Wilson J., Wojcik M., Wu S., Xiao X., Yang C., Ye Z., Zuzel G., Caminata, A, Aalseth, C, Abdelhakim, S, Acerbi, F, Agnes, P, Albuquerque, I, Alexander, T, Alici, A, Alton, A, Amaudruz, P, Ameli, F, Antonioli, P, Arcelli, S, Ardito, R, Arnquist, I, Arpaia, P, Asner, D, Asunskis, A, Ave, M, Back, H, Barrado Olmedo, A, Batignani, G, Bisogni, M, Bocci, V, Bondar, A, Bonfini, G, Bonivento, W, Bottino, B, Boulay, M, Bunker, R, Bussino, S, Buzulutskov, A, Cadeddu, M, Cadoni, M, Canci, N, Candela, A, Cantini, C, Caravati, M, Cariello, M, Carpinelli, M, Castellani, A, Castello, P, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Cebrian, S, Celano, B, Cereseto, R, Cheng, W, Chepurnov, A, Cicalo, C, Ci-Farelli, L, Citterio, M, Cocco, A, Colocci, M, Consiglio, L, Cossio, F, Covone, G, Crivelli, P, D'Antone, I, D'Incecco, M, D'Urso, D, da Rocha Rolo, M, Daniel, M, Davini, S, de Candia, A, de Cecco, S, de Deo, M, de Falco, A, de Filippis, G, de Gruttola, D, de Guido, G, de Rosa, G, Dellacasa, G, Demontis, P, Depaquale, S, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Di Stefano, P, Dionisi, C, Dordei, F, Downing, M, Edalatfar, F, Empl, A, Fernandez Diaz, M, Ferri, A, Filip, C, Fiorillo, G, Fomenko, K, Franceschi, A, Franco, D, Froudakis, G, Gabriele, F, Gabrieli, A, Gal-Biati, C, Garcia Abia, P, Gascon Fora, D, Gendotti, A, Ghiano, C, Ghisi, A, Giagu, S, Giampa, P, Giampaolo, R, Giganti, C, Giorgi, M, Giovanetti, G, Gligan, M, Gola, A, Gorchakov, O, Grab, M, Graciani Diaz, R, Granato, F, Grassi, M, Grate, J, Grigoriev, G, Grobov, A, Gromov, M, Guan, M, Guerra, M, Guerzoni, M, Gulino, M, Haaland, R, Hackett, B, Hallin, A, Harrop, B, Hoppe, E, Horikawa, S, Hosseini, B, Hubaut, F, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, Jillings, C, Jimenez Cabre, S, Keeter, K, Kendziora, C, Kim, S, Kochanek, I, Kondo, K, Kopp, G, Korablev, D, Korga, G, Kubankin, A, Kugathasan, R, Kuss, M, Kuzniak, M, la Commara, M, Lai, M, Langrock, S, Lebois, M, Lehnert, B, Li, X, Liqiang, Q, Lissia, M, Lodi, G, Longo, G, Lussana, R, Luzzi, L, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Marcante, M, Margotti, A, Mari, S, Mariani, M, Maricic, J, Marinelli, M, Marras, D, Martinez Rojas, A, Martoff, C, Mascia, M, Masoni, A, Mazzi, A, Mcdonald, A, Messina, A, Meyers, P, Miletic, T, Milincic, R, Moggi, A, Moioli, S, Monroe, J, Morrocchi, M, Mroz, T, Mu, W, Muratova, V, Murphy, S, Muscas, C, Musico, P, Nania, R, Napolitano, T, Navrer Agasson, A, Nessi, M, Nikulin, I, Nozdrina, A, Nurakhov, N, Oleinik, A, Oleynikov, V, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pal-Mas, S, Pandola, L, Pantic, E, Paoloni, E, Paternoster, G, Pavletcov, V, Pazzona, F, Peeters, S, Pegoraro, P, Pelczar, K, Pellegrini, L, Pelliccia, N, Perotti, F, Pesudo, V, Picciau, E, Piemonte, C, Pietropaolo, F, Pocar, A, Pollman, T, Portaluppi, D, Poudel, S, Price, D, Pugachev, D, Radics, B, Raffaelli, F, Ragusa, F, Razeti, M, Razeto, A, Regazzoni, V, Regenfus, C, Renshaw, A, Rescia, S, Rescigno, M, Retiere, F, Riffard, Q, Rivetti, A, Romani, A, Romero, L, Rossi, N, Rubbia, A, Sablone, D, Sala, P, Salatino, P, Samoylov, O, Sanchez Garcia, E, Sanfilippo, S, Sant, M, Santone, D, San-Torelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Scioli, G, Segreto, E, Seifert, A, Semenov, D, Shchagin, A, She-Myakina, E, Sheshukov, A, Siddhanta, S, Simeone, M, Singh, P, Skensved, P, Skorokhvatov, M, Smirnov, O, So-Brero, G, Sokolov, A, Sotnikov, A, Stainforth, R, Stracka, S, Suffritti, G, Sulis, S, Suvorov, Y, Szelc, A, Tartaglia, R, Testera, G, Thorpe, T, Tonazzo, A, Tosi, A, Unzhakov, E, Usai, G, Vacca, A, Vazquez-Jauregui, E, Verducci, M, Viant, T, Viel, S, Villa, F, Vishneva, A, Vogelaar, R, Wada, M, Wahl, J, Walding, J, Wang, H, Wang, Y, Westerdale, S, Wheadon, R, Williams, R, Wilson, J, Wojcik, M, Wu, S, Xiao, X, Yang, C, Ye, Z, Zuzel, G, Caminata A., Aalseth C. E., Abdelhakim S., Acerbi F., Agnes P., Albuquerque I. F. M., Alexander T., Alici A., Alton A. K., Amaudruz P., Ameli F., Antonioli P., Arcelli S., Ardito R., Arnquist I. J., Arpaia P., Asner D. M., Asunskis A., Ave M., Back H. O., Barrado Olmedo A., Batignani G., Bisogni M. G., Bocci V., Bondar A., Bonfini G., Bonivento W., Bottino B., Boulay M. G., Bunker R., Bussino S., Buzulutskov A., Cadeddu M., Cadoni M., Canci N., Candela A., Cantini C., Caravati M., Cariello M., Carpinelli M., Castellani A., Castello P., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Cebrian S., Celano B., Cereseto R., Cheng W., Chepurnov A., Cicalo C., Ci-Farelli L., Citterio M., Cocco A. G., Colocci M., Consiglio L., Cossio F., Covone G., Crivelli P., D'Antone I., D'Incecco M., D'Urso D., da Rocha Rolo M. D., Daniel M., Davini S., de Candia A., de Cecco S., de Deo M., de Falco A., de Filippis G., de Gruttola D., de Guido G., de Rosa G., Dellacasa G., Demontis P., DePaquale S., Derbin A. V., Devoto A., Di Eusanio F., Di Pietro G., Di Stefano P., Dionisi C., Dordei F., Downing M., Edalatfar F., Empl A., Fernandez Diaz M., Ferri A., Filip C., Fiorillo G., Fomenko K., Franceschi A., Franco D., Froudakis G. E., Gabriele F., Gabrieli A., Gal-Biati C., Garcia Abia P., Gascon Fora D., Gendotti A., Ghiano C., Ghisi A., Giagu S., Giampa P., Giampaolo R. A., Giganti C., Giorgi M. A., Giovanetti G. K., Gligan M. L., Gola A., Gorchakov O., Grab M., Graciani Diaz R., Granato F., Grassi M., Grate J. W., Grigoriev G. Y., Grobov A., Gromov M., Guan M., Guerra M. B. B., Guerzoni M., Gulino M., Haaland R. K., Hackett B. R., Hallin A., Harrop B., Hoppe E. W., Horikawa S., Hosseini B., Hubaut F., Humble P., Hungerford E. V., Ianni An., Ippolito V., Jillings C., Jimenez Cabre S., Keeter K., Kendziora C. L., Kim S., Kochanek I., Kondo K., Kopp G., Korablev D., Korga G., Kubankin A., Kugathasan R., Kuss M., Kuzniak M., la Commara M., Lai M., Langrock S., Lebois M., Lehnert B., Li X., Liqiang Q., Lissia M., Lodi G. U., Longo G., Lussana R., Luzzi L., Machado A. A., Machulin I. N., Mandarano A., Mapelli L., Marcante M., Margotti A., Mari S. M., Mariani M., Maricic J., Marinelli M., Marras D., Martinez Rojas A. D., Martoff C. J., Mascia M., Masoni A., Mazzi A., McDonald A. B., Messina A., Meyers P. D., Miletic T., Milincic R., Moggi A., Moioli S., Monroe J., Morrocchi M., Mroz T., Mu W., Muratova V. N., Murphy S., Muscas C., Musico P., Nania R., Napolitano T., Navrer Agasson A., Nessi M., Nikulin I., Nozdrina A. O., Nurakhov N. N., Oleinik A., Oleynikov V., Orsini M., Ortica F., Pagani L., Pallavicini M., Pal-Mas S., Pandola L., Pantic E., Paoloni E., Paternoster G., Pavletcov V., Pazzona F., Peeters S., Pegoraro P. A., Pelczar K., Pellegrini L. A., Pelliccia N., Perotti F., Pesudo V., Picciau E., Piemonte C., Pietropaolo F., Pocar A., Pollman T., Portaluppi D., Poudel S. S., Price D., Pugachev D. A., Radics B., Raffaelli F., Ragusa F., Razeti M., Razeto A., Regazzoni V., Regenfus C., Renshaw A. L., Rescia S., Rescigno M., Retiere F., Riffard Q., Rivetti A., Romani A., Romero L., Rossi N., Rubbia A., Sablone D., Sala P., Salatino P., Samoylov O., Sanchez Garcia E., Sanfilippo S., Sant M., Santone D., San-Torelli R., Savarese C., Scapparone E., Schlitzer B., Scioli G., Segreto E., Seifert A., Semenov D. A., Shchagin A., She-Myakina E., Sheshukov A., Siddhanta S., Simeone M., Singh P. N., Skensved P., Skorokhvatov M. D., Smirnov O., So-Brero G., Sokolov A., Sotnikov A., Stainforth R., Stracka S., Suffritti G. B., Sulis S., Suvorov Y., Szelc A. M., Tartaglia R., Testera G., Thorpe T., Tonazzo A., Tosi A., Unzhakov E. V., Usai G., Vacca A., Vazquez-Jauregui E., Verducci M., Viant T., Viel S., Villa F., Vishneva A., Vogelaar R. B., Wada M., Wahl J., Walding J. J., Wang H., Wang Y., Westerdale S., Wheadon R. J., Williams R., Wilson J., Wojcik M., Wu S., Xiao X., Yang C., Ye Z., and Zuzel G.
Abstract: DarkSide uses a dual-phase Liquid Argon Time Projection Chamber (TPC) to search for WIMP dark matter. The paper will present the latest result on the search for low mass (MW IMP < 20 Gev/c2) and high mass (MW IMP > 100 Gev/c2) WIMPs from the current experiment, DarkSide-50, running since mid 2015 a 50-kg-active-mass TPC, filled with argon from an underground source. The next stage of the DarkSide program will be a new generation experiment involving a global collaboration from all the current Argon based experiments. DarkSide-20k, is designed as a 20-tonne fiducial mass TPC with SiPM based photosensors, expected to be free of any background for an exposure of >100 ton x years. Like its predecessor DarkSide-20k will be housed at the Gran Sasso (LNGS) underground laboratory, and it is expected to attain a WIMP-nucleon cross section exclusion sensitivity of 10−47 cm2 for a WIMP mass of 1 TeV /c2 in a 5 yr run. A subsequent objective, towards the end of the next decade, will be the construction of the ultimate detector, ARGO, with a 300 t fiducial mass to push the sensitivity to the neutrino floor region for high mass WIMPs. The combination of the three experiments, part of a single family, will cover completely the WIMP hypothesis from 1 GeV /c2 to several hundreds of TeV /c2 masses.
Published: 2019

36. DarkSide-50 results and the future liquid argon dark matter program

Author: Caminata, A., Aalseth, C. E., Abdelhakim, S., Acerbi, F., Agnes, P., Albuquerque, I. F. M., Alexander, T., Alici, A., Alton, A. K., Amaudruz, P., Ameli, F., Antonioli, P., Arcelli, S., Ardito, R., Arnquist, I. J., Arpaia, P., Asner, D. M., Asunskis, A., Ave, M., Back, H. O., Barrado Olmedo, A., Batignani, G., Bisogni, M. G., Bocci, V., Bondar, A., Bonfini, G., Bonivento, W., Bottino, B., Boulay, M. G., Bunker, R., Bussino, S., Buzulutskov, A., Cadeddu, M., Cadoni, M., Canci, N., Candela, A., Cantini, C., Caravati, M., Cariello, M., Carpinelli, M., Castellani, A., Castello, P., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Cebrian, S., Celano, B., Cereseto, R., Cheng, W., Chepurnov, A., Cicalò, C., Ci-Farelli, L., Citterio, M., Cocco, A. G., Colocci, M., Consiglio, L., Cossio, F., Covone, G., Crivelli, P., D Antone, I., D Incecco, M., D Urso, D., Da Rocha Rolo, M. D., Daniel, M., Davini, S., Candia, A., Cecco, S., Deo, M., Falco, A., Filippis, G., Gruttola, D., Guido, G., Rosa, G., Dellacasa, G., Demontis, P., Depaquale, S., Derbin, A. V., Devoto, A., Di Eusanio, F., Di Pietro, G., Di Stefano, P., Dionisi, C., Dordei, F., Downing, M., Edalatfar, F., Empl, A., Fernandez Diaz, M., Ferri, A., Filip, C., Fiorillo, G., Fomenko, K., Franceschi, A., Franco, D., Froudakis, G. E., Gabriele, F., Gabrieli, A., Gal-Biati, C., Garcia Abia, P., Gascón Fora, D., Gendotti, A., Ghiano, C., Ghisi, A., Giagu, S., Giampa, P., Giampaolo, R. A., Giganti, C., Giorgi, M. A., Giovanetti, G. K., Gligan, M. L., Gola, A., Gorchakov, O., Grab, M., Graciani Diaz, R., Granato, F., Grassi, M., Grate, J. W., Grigoriev, G. Y., Grobov, A., Gromov, M., Guan, M., Guerra, M. B. B., Guerzoni, M., Gulino, M., Haaland, R. K., Hackett, B. R., Hallin, A., Harrop, B., Hoppe, E. W., Horikawa, S., Hosseini, B., Hubaut, F., Humble, P., Hungerford, E. V., Ianni, An, Ippolito, V., Jillings, C., Jimenez Cabre, S., Keeter, K., Kendziora, C. L., Kim, S., Kochanek, I., Kondo, K., Kopp, G., Korablev, D., Korga, G., Kubankin, A., Kugathasan, R., Kuss, M., Kuzniak, M., La Commara, M., Lai, M., Langrock, S., Lebois, M., Lehnert, B., Li, X., Liqiang, Q., Lissia, M., Lodi, G. U., Longo, G., Lussana, R., Luzzi, L., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Marcante, M., Margotti, A., Mari, S. M., Mariani, M., Maricic, J., Marinelli, M., Marras, D., Martinez Rojas, A. D., Martoff, C. J., Mascia, M., Masoni, A., Mazzi, A., Mcdonald, A. B., Messina, A., Meyers, P. D., Miletic, T., Milincic, R., Moggi, A., Moioli, S., Jocelyn Monroe, Morrocchi, M., Mroz, T., Mu, W., Muratova, V. N., Murphy, S., Muscas, C., Musico, P., Nania, R., Napolitano, T., Navrer Agasson, A., Nessi, M., Nikulin, I., Nozdrina, A. O., Nurakhov, N. N., Oleinik, A., Oleynikov, V., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pal-Mas, S., Pandola, L., Pantic, E., Paoloni, E., Paternoster, G., Pavletcov, V., Pazzona, F., Peeters, S., Pegoraro, P. A., Pelczar, K., Pellegrini, L. A., Pelliccia, N., Perotti, F., Pesudo, V., Picciau, E., Piemonte, C., Pietropaolo, F., Pocar, A., Pollman, T., Portaluppi, D., Poudel, S. S., Price, D., Pugachev, D. A., Radics, B., Raffaelli, F., Ragusa, F., Razeti, M., Razeto, A., Regazzoni, V., Regenfus, C., Renshaw, A. L., Rescia, S., Rescigno, M., Retiere, F., Riffard, Q., Rivetti, A., Romani, A., Romero, L., Rossi, N., Rubbia, A., Sablone, D., Sala, P., Salatino, P., Samoylov, O., Sànchez Garcìa, E., Sanfilippo, S., Sant, M., Santone, D., San-Torelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Scioli, G., Segreto, E., Seifert, A., Semenov, D. A., Shchagin, A., She-Myakina, E., Sheshukov, A., Siddhanta, S., Simeone, M., Singh, P. N., Skensved, P., Skorokhvatov, M. D., Smirnov, O., So-Brero, G., Sokolov, A., Sotnikov, A., Stainforth, R., Stracka, S., Suffritti, G. B., Sulis, S., Suvorov, Y., Szelc, A. M., Tartaglia, R., Testera, G., Thorpe, T., Tonazzo, A., Tosi, A., Unzhakov, E. V., Usai, G., Vacca, A., Vázquez-Jáuregui, E., Verducci, M., Viant, T., Viel, S., Villa, F., Vishneva, A., Vogelaar, R. B., Wada, M., Wahl, J., Walding, J. J., Wang, H., Wang, Y., Westerdale, S., Wheadon, R. J., Williams, R., Wilson, J., Wojcik, M., Wu, S., Xiao, X., Yang, C., Ye, Z., Zuzel, G., Caminata, A., Aalseth, C. E., Abdelhakim, S., Acerbi, F., Agnes, P., Albuquerque, I. F. M., Alexander, T., Alici, A., Alton, A. K., Amaudruz, P., Ameli, F., Antonioli, P., Arcelli, S., Ardito, R., Arnquist, I. J., Arpaia, P., Asner, D. M., Asunskis, A., Ave, M., Back, H. O., Barrado Olmedo, A., Batignani, G., Bisogni, M. G., Bocci, V., Bondar, A., Bonfini, G., Bonivento, W., Bottino, B., Boulay, M. G., Bunker, R., Bussino, S., Buzulutskov, A., Cadeddu, M., Cadoni, M., Canci, N., Candela, A., Cantini, C., Caravati, M., Cariello, M., Carpinelli, M., Castellani, A., Castello, P., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Cebrian, S., Celano, B., Cereseto, R., Cheng, W., Chepurnov, A., Cicalo, C., Ci-Farelli, L., Citterio, M., Cocco, A. G., Colocci, M., Consiglio, L., Cossio, F., Covone, G., Crivelli, P., D'Antone, I., D'Incecco, M., D'Urso, D., da Rocha Rolo, M. D., Daniel, M., Davini, S., de Candia, A., de Cecco, S., de Deo, M., de Falco, A., de Filippis, G., de Gruttola, D., de Guido, G., de Rosa, G., Dellacasa, G., Demontis, P., Depaquale, S., Derbin, A. V., Devoto, A., Di Eusanio, F., Di Pietro, G., Di Stefano, P., Dionisi, C., Dordei, F., Downing, M., Edalatfar, F., Empl, A., Fernandez Diaz, M., Ferri, A., Filip, C., Fiorillo, G., Fomenko, K., Franceschi, A., Franco, D., Froudakis, G. E., Gabriele, F., Gabrieli, A., Gal-Biati, C., Garcia Abia, P., Gascon Fora, D., Gendotti, A., Ghiano, C., Ghisi, A., Giagu, S., Giampa, P., Giampaolo, R. A., Giganti, C., Giorgi, M. A., Giovanetti, G. K., Gligan, M. L., Gola, A., Gorchakov, O., Grab, M., Graciani Diaz, R., Granato, F., Grassi, M., Grate, J. W., Grigoriev, G. Y., Grobov, A., Gromov, M., Guan, M., Guerra, M. B. B., Guerzoni, M., Gulino, M., Haaland, R. K., Hackett, B. R., Hallin, A., Harrop, B., Hoppe, E. W., Horikawa, S., Hosseini, B., Hubaut, F., Humble, P., Hungerford, E. V., Ianni, An., Ippolito, V., Jillings, C., Jimenez Cabre, S., Keeter, K., Kendziora, C. L., Kim, S., Kochanek, I., Kondo, K., Kopp, G., Korablev, D., Korga, G., Kubankin, A., Kugathasan, R., Kuss, M., Kuzniak, M., la Commara, M., Lai, M., Langrock, S., Lebois, M., Lehnert, B., Li, X., Liqiang, Q., Lissia, M., Lodi, G. U., Longo, G., Lussana, R., Luzzi, L., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Marcante, M., Margotti, A., Mari, S. M., Mariani, M., Maricic, J., Marinelli, M., Marras, D., Martinez Rojas, A. D., Martoff, C. J., Mascia, M., Masoni, A., Mazzi, A., Mcdonald, A. B., Messina, A., Meyers, P. D., Miletic, T., Milincic, R., Moggi, A., Moioli, S., Monroe, J., Morrocchi, M., Mroz, T., Mu, W., Muratova, V. N., Murphy, S., Muscas, C., Musico, P., Nania, R., Napolitano, T., Navrer Agasson, A., Nessi, M., Nikulin, I., Nozdrina, A. O., Nurakhov, N. N., Oleinik, A., Oleynikov, V., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pal-Mas, S., Pandola, L., Pantic, E., Paoloni, E., Paternoster, G., Pavletcov, V., Pazzona, F., Peeters, S., Pegoraro, P. A., Pelczar, K., Pellegrini, L. A., Pelliccia, N., Perotti, F., Pesudo, V., Picciau, E., Piemonte, C., Pietropaolo, F., Pocar, A., Pollman, T., Portaluppi, D., Poudel, S. S., Price, D., Pugachev, D. A., Radics, B., Raffaelli, F., Ragusa, F., Razeti, M., Razeto, A., Regazzoni, V., Regenfus, C., Renshaw, A. L., Rescia, S., Rescigno, M., Retiere, F., Riffard, Q., Rivetti, A., Romani, A., Romero, L., Rossi, N., Rubbia, A., Sablone, D., Sala, P., Salatino, P., Samoylov, O., Sanchez Garcia, E., Sanfilippo, S., Sant, M., Santone, D., San-Torelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Scioli, G., Segreto, E., Seifert, A., Semenov, D. A., Shchagin, A., She-Myakina, E., Sheshukov, A., Siddhanta, S., Simeone, M., Singh, P. N., Skensved, P., Skorokhvatov, M. D., Smirnov, O., So-Brero, G., Sokolov, A., Sotnikov, A., Stainforth, R., Stracka, S., Suffritti, G. B., Sulis, S., Suvorov, Y., Szelc, A. M., Tartaglia, R., Testera, G., Thorpe, T., Tonazzo, A., Tosi, A., Unzhakov, E. V., Usai, G., Vacca, A., Vazquez-Jauregui, E., Verducci, M., Viant, T., Viel, S., Villa, F., Vishneva, A., Vogelaar, R. B., Wada, M., Wahl, J., Walding, J. J., Wang, H., Wang, Y., Westerdale, S., Wheadon, R. J., Williams, R., Wilson, J., Wojcik, M., Wu, S., Xiao, X., Yang, C., Ye, Z., Zuzel, G., Caminata, A, Aalseth, C, Abdelhakim, S, Acerbi, F, Agnes, P, Albuquerque, I, Alexander, T, Alici, A, Alton, A, Amaudruz, P, Ameli, F, Antonioli, P, Arcelli, S, Ardito, R, Arnquist, I, Arpaia, P, Asner, D, Asunskis, A, Ave, M, Back, H, Barrado Olmedo, A, Batignani, G, Bisogni, M, Bocci, V, Bondar, A, Bonfini, G, Bonivento, W, Bottino, B, Boulay, M, Bunker, R, Bussino, S, Buzulutskov, A, Cadeddu, M, Cadoni, M, Canci, N, Candela, A, Cantini, C, Caravati, M, Cariello, M, Carpinelli, M, Castellani, A, Castello, P, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Cebrian, S, Celano, B, Cereseto, R, Cheng, W, Chepurnov, A, Cicalo, C, Ci-Farelli, L, Citterio, M, Cocco, A, Colocci, M, Consiglio, L, Cossio, F, Covone, G, Crivelli, P, D'Antone, I, D'Incecco, M, D'Urso, D, da Rocha Rolo, M, Daniel, M, Davini, S, de Candia, A, de Cecco, S, de Deo, M, de Falco, A, de Filippis, G, de Gruttola, D, de Guido, G, de Rosa, G, Dellacasa, G, Demontis, P, Depaquale, S, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Di Stefano, P, Dionisi, C, Dordei, F, Downing, M, Edalatfar, F, Empl, A, Fernandez Diaz, M, Ferri, A, Filip, C, Fiorillo, G, Fomenko, K, Franceschi, A, Franco, D, Froudakis, G, Gabriele, F, Gabrieli, A, Gal-Biati, C, Garcia Abia, P, Gascon Fora, D, Gendotti, A, Ghiano, C, Ghisi, A, Giagu, S, Giampa, P, Giampaolo, R, Giganti, C, Giorgi, M, Giovanetti, G, Gligan, M, Gola, A, Gorchakov, O, Grab, M, Graciani Diaz, R, Granato, F, Grassi, M, Grate, J, Grigoriev, G, Grobov, A, Gromov, M, Guan, M, Guerra, M, Guerzoni, M, Gulino, M, Haaland, R, Hackett, B, Hallin, A, Harrop, B, Hoppe, E, Horikawa, S, Hosseini, B, Hubaut, F, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, Jillings, C, Jimenez Cabre, S, Keeter, K, Kendziora, C, Kim, S, Kochanek, I, Kondo, K, Kopp, G, Korablev, D, Korga, G, Kubankin, A, Kugathasan, R, Kuss, M, Kuzniak, M, la Commara, M, Lai, M, Langrock, S, Lebois, M, Lehnert, B, Li, X, Liqiang, Q, Lissia, M, Lodi, G, Longo, G, Lussana, R, Luzzi, L, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Marcante, M, Margotti, A, Mari, S, Mariani, M, Maricic, J, Marinelli, M, Marras, D, Martinez Rojas, A, Martoff, C, Mascia, M, Masoni, A, Mazzi, A, Mcdonald, A, Messina, A, Meyers, P, Miletic, T, Milincic, R, Moggi, A, Moioli, S, Monroe, J, Morrocchi, M, Mroz, T, Mu, W, Muratova, V, Murphy, S, Muscas, C, Musico, P, Nania, R, Napolitano, T, Navrer Agasson, A, Nessi, M, Nikulin, I, Nozdrina, A, Nurakhov, N, Oleinik, A, Oleynikov, V, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pal-Mas, S, Pandola, L, Pantic, E, Paoloni, E, Paternoster, G, Pavletcov, V, Pazzona, F, Peeters, S, Pegoraro, P, Pelczar, K, Pellegrini, L, Pelliccia, N, Perotti, F, Pesudo, V, Picciau, E, Piemonte, C, Pietropaolo, F, Pocar, A, Pollman, T, Portaluppi, D, Poudel, S, Price, D, Pugachev, D, Radics, B, Raffaelli, F, Ragusa, F, Razeti, M, Razeto, A, Regazzoni, V, Regenfus, C, Renshaw, A, Rescia, S, Rescigno, M, Retiere, F, Riffard, Q, Rivetti, A, Romani, A, Romero, L, Rossi, N, Rubbia, A, Sablone, D, Sala, P, Salatino, P, Samoylov, O, Sanchez Garcia, E, Sanfilippo, S, Sant, M, Santone, D, San-Torelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Scioli, G, Segreto, E, Seifert, A, Semenov, D, Shchagin, A, She-Myakina, E, Sheshukov, A, Siddhanta, S, Simeone, M, Singh, P, Skensved, P, Skorokhvatov, M, Smirnov, O, So-Brero, G, Sokolov, A, Sotnikov, A, Stainforth, R, Stracka, S, Suffritti, G, Sulis, S, Suvorov, Y, Szelc, A, Tartaglia, R, Testera, G, Thorpe, T, Tonazzo, A, Tosi, A, Unzhakov, E, Usai, G, Vacca, A, Vazquez-Jauregui, E, Verducci, M, Viant, T, Viel, S, Villa, F, Vishneva, A, Vogelaar, R, Wada, M, Wahl, J, Walding, J, Wang, H, Wang, Y, Westerdale, S, Wheadon, R, Williams, R, Wilson, J, Wojcik, M, Wu, S, Xiao, X, Yang, C, Ye, Z, and Zuzel, G
Subjects: Physics, Particle physics, Time projection chamber, Argon, Dark matter, Detector, chemistry.chemical_element, Galaxie, Germanium compound, Silicon photomultiplier, WIMP, chemistry, Dark Matter, Neutrino, Low Mass, Liquefied gases
Abstract: DarkSide uses a dual-phase Liquid Argon Time Projection Chamber (TPC) to search for WIMP dark matter. The paper will present the latest result on the search for low mass (MW IMP < 20 Gev/c2) and high mass (MW IMP > 100 Gev/c2) WIMPs from the current experiment, DarkSide-50, running since mid 2015 a 50-kg-active-mass TPC, filled with argon from an underground source. The next stage of the DarkSide program will be a new generation experiment involving a global collaboration from all the current Argon based experiments. DarkSide-20k, is designed as a 20-tonne fiducial mass TPC with SiPM based photosensors, expected to be free of any background for an exposure of >100 ton x years. Like its predecessor DarkSide-20k will be housed at the Gran Sasso (LNGS) underground laboratory, and it is expected to attain a WIMP-nucleon cross section exclusion sensitivity of 10−47 cm2 for a WIMP mass of 1 TeV /c2 in a 5 yr run. A subsequent objective, towards the end of the next decade, will be the construction of the ultimate detector, ARGO, with a 300 t fiducial mass to push the sensitivity to the neutrino floor region for high mass WIMPs. The combination of the three experiments, part of a single family, will cover completely the WIMP hypothesis from 1 GeV /c2 to several hundreds of TeV /c2 masses.
Published: 2019

37. DarkSide: Latest results and future perspectives

Author: Bottino, B., Agnes, P., Albuquerque, I.F.M., Alexander, T., Alton, A.K., Asner, D.M., Ave, M.P., Back, H.O., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cardenas, M.M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Chepurnov, A., Cicalò, C., Cifarelli, L., Cocco, A.G., Covone, G., D'Angelo, D., D'Incecco, M., D'Urso, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., De Vincenzi, M., Derbin, A.V., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Galbiati, C., Garcia Abia, P., Ghiano, C., Giagu, S., Giganti, C., Giovanetti, G.K., Gorchakov, O., Goretti, A.M., Granato, F., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B.R., Herner, K., Hosseini, B., Hughes, D., Humble, P., Hungerford, E.V., Ianni, An., Ippolito, V., James, I., Johnson, T.N., Keeter, K., Kendziora, C.L., Kochanek, I., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., Commara, M.La, Lai, M., Li, X., Lissia, M., Longo, G., Machado, A.A., Machulin, I.N., Mandarano, A., Mapelli, L., Mari, S.M., Maricic, J., Martoff, C.J., Messina, A., Meyers, P.D., Milincic, R., Monte, A., Morrocchi, M., Mount, B.J., Muratova, V.N., Musico, P., Nania, R., Navrer Agasson, A., Nozdrina, A.O., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Pesudo, V., Pocar, A., Pordes, S., Poudel, S.S., Pugachev, D.A., Qian, H., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A.L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Segreto, E., Semenov, D.A., Shchagin, A., Sheshukov, A., Simeone, M., Singh, P.N., Skorokhvatov, M.D., Smirnov, O., Sotnikov, A., Stanford, C., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E.V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Waldrop, T.J., Wang, H., Wang, Y., Watson, A.W., Westerdale, S., Wojcik, M.M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., Zuzel, G., Bottino, B., Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Asner, D. M., Ave, M. P., Back, H. O., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cardenas, M. M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Chepurnov, A., Cicalò, C., Cifarelli, L., Cocco, A. G., Covone, G., D'Angelo, D., D'Incecco, M., D'Urso, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., De Vincenzi, M., Derbin, A. V., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Galbiati, C., Garcia Abia, P., Ghiano, C., Giagu, S., Giganti, C., Giovanetti, G. K., Gorchakov, O., Goretti, A. M., Granato, F., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B. R., Herner, K., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, An., Ippolito, V., James, I., Johnson, T. N., Keeter, K., Kendziora, C. L., Kochanek, I., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Mari, S. M., Maricic, J., Martoff, C. J., Messina, A., Meyers, P. D., Milincic, R., Monte, A., Morrocchi, M., Mount, B. J., Muratova, V. N., Musico, P., Nania, R., Navrer Agasson, A., Nozdrina, A. O., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Pesudo, V., Pocar, A., Pordes, S., Poudel, S. S., Pugachev, D. A., Qian, H., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Segreto, E., Semenov, D. A., Shchagin, A., Sheshukov, A., Simeone, M., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Waldrop, T. J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., Zuzel, G., Ave, Mp., Cicalo, C., AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), DarkSide, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Bottino, B, Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Asner, D, Ave, M, Back, H, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cardenas, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cifarelli, L, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, De Vincenzi, M, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Edkins, E, Empl, A, Fan, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Galbiati, C, Garcia Abia, P, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, James, I, Johnson, T, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, La Commara, M, Lai, M, Li, X, Lissia, M, Longo, G, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Monte, A, Morrocchi, M, Mount, B, Muratova, V, Musico, P, Nania, R, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pelczar, K, Pelliccia, N, Pesudo, V, Pocar, A, Pordes, S, Poudel, S, Pugachev, D, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Santorelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Simeone, M, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zuzel, G, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: electron, background, Physics::Instrumentation and Detectors, DarkSide, Astrophysics::Instrumentation and Methods for Astrophysics, WIMP: mass, dark matter: direct detection, liquid argon, Gran Sasso, time projection chamber, Automatic Keywords, cryogenics, muon, argon, duality, photomultiplier: silicon, High Energy Physics::Experiment, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Nuclear Experiment, nucleus: recoil
Abstract: International audience; DarkSide is direct-detection dark-matter experimental project based on radiopure argon. The main goal of the DarkSide program is the detection of rare nuclear elastic collisions with hypothetical dark-matter particles. The present detector, DarkSide-50, placed at Laboratori Nazionali del Gran Sasso (LNGS), is a dualphase time projection chamber (TPC) filled with ultra-pure liquid argon, extracted from underground sources. Surrounding the TPC to suppress the background there are neutron and muon active vetoes. One of argon key features is the capability to distinguish between electron and nuclear recoils, exploiting the different shapes of the signals. DarkSide-50 new results, obtained using a live-days exposure of 532.4 days, are presented. This analysis sets a 90% C.L. upper limit on the dark matternucleon spin-independent cross-section of 1.1 × 10−44 cm2 for a WIMP mass of 100 GeV/c2. The next phase of the project, DarkSide-20k, will be a new detector with a fiducial mass of ∼ 20 tons, equipped with cryogenic silicon photomultipliers (SiPM).
Published: 2019
Full Text: View/download PDF

38. Latest results of dark matter detection with the DarkSide experiment

Author: Picciau, E., Agnes, P., Albuquerque, I. F. M., Alton, A. K., Ave, M., Back, H. O., Batignani, G., Biery, K., Bocci, V, Bonfini, G., Bonivento, W. M., Bottino, B., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V, Cavalcante, P., Cavuoti, S., Chepurnov, A., Cicalo, C., Cocco, A. G., Covone, G., D'Angelo, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., Derbin A., V, Devoto, A., Di Eusanio, F., D'Incecco, M., Di Pietro, G., Dionisi, C., Downing, M., D'Urso, D., Edkins, E., Empl, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Galbiati, C., Ghiano, C., Giagu, S., Giganti, C., Giovanetti, G. K., Gorchakov, O., Goretti, A. M., Granato, F., Grobov, A., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B. R., Horner, K., Hosseini, B., Hughes, D., Humble, P., Hungerford E., Ianni, Al, Ianni, An, Ippolito, V, Johnson, T. N., Keeter, K., Kendziora, C. L., Kochanek, I, Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Mari, S. M., Maricic, J., Martoff, C. J., Messina, A., Meyers, P. D., Milincic, R., Monte, A., Morrocchi, M., Muratova, V. N., Musico, P., Agasson, A. Navrer, Nozdrina, A. O., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantie, E., Paoloni, E., Pelczar, K., Pelliccia, N., Pocar, A., Pordes, S., Poudel, S. S., Qian, H., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Sainoylov, O., Sands, W., Savarese, C., Schlitzer, B., Segreto, E., Semenov, D. A., Shchagin, A., Sheshukov, A., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov E., Verducci, M., Vishneva, A., Vogelaar, R. B., Wada, M., Waldrop, T. J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., Zuzel, G., Picciau, E., Agnes, P., Albuquerque, I. F. M., Alton, A. K., Ave, M., Back, H. O., Batignani, G., Biery, K., Bocci, V, Bonfini, G., Bonivento, W. M., Bottino, B., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V, Cavalcante, P., Cavuoti, S., Chepurnov, A., Cicalo, C., Cocco, A. G., Covone, G., D'Angelo, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., Derbin, A., V, Devoto, A., Di Eusanio, F., D'Incecco, M., Di Pietro, G., Dionisi, C., Downing, M., D'Urso, D., Edkins, E., Empl, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Galbiati, C., Ghiano, C., Giagu, S., Giganti, C., Giovanetti, G. K., Gorchakov, O., Goretti, A. M., Granato, F., Grobov, A., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B. R., Horner, K., Hosseini, B., Hughes, D., Humble, P., Hungerford, E., Ianni, Al, Ianni, An, Ippolito, V, Johnson, T. N., Keeter, K., Kendziora, C. L., Kochanek, I, Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Mari, S. M., Maricic, J., Martoff, C. J., Messina, A., Meyers, P. D., Milincic, R., Monte, A., Morrocchi, M., Muratova, V. N., Musico, P., Agasson, A. Navrer, Nozdrina, A. O., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantie, E., Paoloni, E., Pelczar, K., Pelliccia, N., Pocar, A., Pordes, S., Poudel, S. S., Qian, H., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Sainoylov, O., Sands, W., Savarese, C., Schlitzer, B., Segreto, E., Semenov, D. A., Shchagin, A., Sheshukov, A., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E., Verducci, M., Vishneva, A., Vogelaar, R. B., Wada, M., Waldrop, T. J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., and Zuzel, G.
Published: 2020

39. VATS Trisegmentectomy Resection of Aspergilloma with Pan-Azole Resistance?

Author: Nawaz Muhammad Asghar, Granato F, Denning David W, and Kler Aaron
Subjects: medicine.medical_specialty, business.industry, Medicine, Azole resistance, business, medicine.disease, Aspergilloma, Surgery, Resection
Published: 2021
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40. DarkSide status and prospects

Author: Sanfilippo, S., Agnes, P., Albuquerque, I.F.M., Alexander, T., Alton, A.K., Asner, D.M., Ave, M.P., Back, H.O., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bottino, B., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cardenas, M.M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Chepurnov, A., Cicalò, C., Cifarelli, L., Cocco, A.G., Covone, G., D'Angelo, D., D'Incecco, M., D'Urso, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., De Vincenzi, M., Derbin, A.V., Devoto, A., Eusanio, F.Di, Pietro, G.Di, Dionisi, C., Edkins, E., Empl, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Galbiati, C., Abia, P.Garcia, Ghiano, C., Giagu, S., Giganti, C., Giovanetti, G.K., Gorchakov, O., Goretti, A.M., Granato, F., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B.R., Herner, K., Horikawa, S., Hosseini, B., Hughes, D., Humble, P., Hungerford, E.V., Ianni, An., Ippolito, V., James, I., Keeter, K., Kendziora, C.L., Kochanek, I., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., Commara, M.La, Lai, M., Li, X., Lissia, M., Longo, G., Machado, A.A., Machulin, I.N., Mandarano, A., Mapelli, L., Mari, S.M., Maricic, J., Martoff, C.J., Messina, A., Meyers, P.D., Milincic, R., Monte, A., Morrocchi, M., Muratova, V.N., Musico, P., Nania, R., Agasson, A.Navrer, Nozdrina, A.O., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Pesudo, V., Picciau, E., Pocar, A., Pordes, S., Poudel, S.S., Pugachev, D.A., Qian, H., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A.L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Segreto, E., Semenov, D.A., Shchagin, A., Sheshukov, A., Simeone, M., Singh, P.N., Skorokhvatov, M.D., Smirnov, O., Sotnikov, A., Stanford, C., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E.V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Waldrop, T.J., Wang, H., Wang, Y., Watson, A.W., Westerdale, S., Wojcik, M.M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., Zuzel, G., AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), DarkSide, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sanfilippo, S, Agnes, P, M Albuquerque, I, Alexander, T, Alton, A, Asner, D, Ave, M, Back, H, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Budano, F, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cardenas, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cifarelli, L, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, De Vincenzi, M, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Edkins, E, Empl, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Galbiati, C, Garcia Abia, P, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Herner, K, Horikawa, S, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, James, I, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, La Commara, M, Lai, M, Li, X, Lissia, M, Longo, G, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Jmartoff, C, Messina, A, Meyers, P, Milincic, R, Monte, A, Morrocchi, M, Muratova, V, Musico, P, Nania, R, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pelczar, K, Pelliccia, N, Pesudo, V, Picciau, E, Pocar, A, Pordes, S, Poudel, S, Pugachev, D, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Santorelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Simeone, M, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zuzel, G, Sanfilippo, S., Agnes, P., M Albuquerque, I. F., Alexander, T., Alton, A. K., Asner, D. M., Ave, M. P., Back, H. O., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bottino, B., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cardenas, M. M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Chepurnov, A., Cicalo, C., Cifarelli, L., Cocco, A. G., Covone, G., D'Angelo, D., D'Incecco, M., D'Urso, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., De Vincenzi, M., Derbin, A. V., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Edkins, E., Empl, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Galbiati, C., Garcia Abia, P., Ghiano, C., Giagu, S., Giganti, C., Giovanetti, G. K., Gorchakov, O., Goretti, A. M., Granato, F., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B. R., Herner, K., Horikawa, S., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, An., Ippolito, V., James, I., Keeter, K., Kendziora, C. L., Kochanek, I., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Mari, S. M., Maricic, J., Jmartoff, C., Messina, A., Meyers, P. D., Milincic, R., Monte, A., Morrocchi, M., Muratova, V. N., Musico, P., Nania, R., Navrer Agasson, A., Nozdrina, A. O., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Pesudo, V., Picciau, E., Pocar, A., Pordes, S., Poudel, S. S., Pugachev, D. A., Qian, H., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Segreto, E., Semenov, D. A., Shchagin, A., Sheshukov, A., Simeone, M., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Waldrop, T. J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., Zuzel, G., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Matter, Physics::Instrumentation and Detectors, WIMP nucleus: scattering, dark matter: mass, Astrophysics::Instrumentation and Methods for Astrophysics, WIMP nucleus: interaction, WIMP: mass, dark matter: direct detection, time projection chamber: liquid argon, WIMP: dark matter, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Experiment, Nuclear Experiment, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], experimental results
Abstract: International audience; DarkSide uses a dual-phase Liquid Argon Time Projection Chamber to search for WIMP dark matter. The current detector, DarkSide-50, is running since mid 2015 with a target of 50 kg of Argon from an underground source. Here it is presented the latest results of searches of WIMP-nucleus interactions, with WIMP masses in the GeV-TeV range, and of WIMP-electron interactions, in the sub-GeV mass range. The future of DarkSide with a new generation experiment, involving a global collaboration from all the current Argon based experiments, is presented.
Published: 2018
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41. DarkSide-50 532-day dark matter search with low-radioactivity argon

Author: Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Araujo, G, Ave, M, Back, H, Baldin, B, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Budano, F, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, De Vincenzi, M, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Downing, M, Edkins, E, Empl, A, Fan, A, Fiorillo, G, Fitzpatrick, R, Fomenko, K, Franco, D, Gabriele, F, Galbiati, C, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, James, I, Johnson, T, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, La Commara, M, Lai, M, Li, X, Lissia, M, Longo, G, Ma, Y, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Monte, A, Morrocchi, M, Mount, B, Muratova, V, Musico, P, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pelczar, K, Pelliccia, N, Pocar, A, Pordes, S, Poudel, S, Pugachev, D, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Reinhold, B, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Savarese, C, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zuzel, G, Agnes P., Albuquerque I. F. M., Alexander T., Alton A. K., Araujo G. R., Ave M., Back H. O., Baldin B., Batignani G., Biery K., Bocci V., Bonfini G., Bonivento W., Bottino B., Budano F., Bussino S., Cadeddu M., Cadoni M., Calaprice F., Caminata A., Canci N., Candela A., Caravati M., Cariello M., Carlini M., Carpinelli M., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Chepurnov A., Cicalo C., Cocco A. G., Covone G., D'Angelo D., D'Incecco M., D'Urso D., Davini S., De Candia A., De Cecco S., De Deo M., De Filippis G., De Rosa G., De Vincenzi M., Derbin A. V., Devoto A., Di Eusanio F., Di Pietro G., Dionisi C., Downing M., Edkins E., Empl A., Fan A., Fiorillo G., Fitzpatrick R. S., Fomenko K., Franco D., Gabriele F., Galbiati C., Ghiano C., Giagu S., Giganti C., Giovanetti G. K., Gorchakov O., Goretti A. M., Granato F., Gromov M., Guan M., Guardincerri Y., Gulino M., Hackett B. R., Herner K., Hosseini B., Hughes D., Humble P., Hungerford E. V., Ianni A., Ippolito V., James I., Johnson T. N., Keeter K., Kendziora C. L., Kochanek I., Koh G., Korablev D., Korga G., Kubankin A., Kuss M., La Commara M., Lai M., Li X., Lissia M., Longo G., Ma Y., Machado A. A., Machulin I. N., Mandarano A., Mapelli L., Mari S. M., Maricic J., Martoff C. J., Messina A., Meyers P. D., Milincic R., Monte A., Morrocchi M., Mount B. J., Muratova V. N., Musico P., Navrer Agasson A., Nozdrina A. O., Oleinik A., Orsini M., Ortica F., Pagani L., Pallavicini M., Pandola L., Pantic E., Paoloni E., Pelczar K., Pelliccia N., Pocar A., Pordes S., Poudel S. S., Pugachev D. A., Qian H., Ragusa F., Razeti M., Razeto A., Reinhold B., Renshaw A. L., Rescigno M., Riffard Q., Romani A., Rossi B., Rossi N., Sablone D., Samoylov O., Sands W., Sanfilippo S., Savarese C., Schlitzer B., Segreto E., Semenov D. A., Shchagin A., Sheshukov A., Singh P. N., Skorokhvatov M. D., Smirnov O., Sotnikov A., Stanford C., Stracka S., Suvorov Y., Tartaglia R., Testera G., Tonazzo A., Trinchese P., Unzhakov E. V., Verducci M., Vishneva A., Vogelaar B., Wada M., Waldrop T. J., Wang H., Wang Y., Watson A. W., Westerdale S., Wojcik M. M., Xiang X., Xiao X., Yang C., Ye Z., Zhu C., Zuzel G., Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Araujo, G, Ave, M, Back, H, Baldin, B, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Budano, F, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, De Vincenzi, M, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Downing, M, Edkins, E, Empl, A, Fan, A, Fiorillo, G, Fitzpatrick, R, Fomenko, K, Franco, D, Gabriele, F, Galbiati, C, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, James, I, Johnson, T, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, La Commara, M, Lai, M, Li, X, Lissia, M, Longo, G, Ma, Y, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Monte, A, Morrocchi, M, Mount, B, Muratova, V, Musico, P, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pelczar, K, Pelliccia, N, Pocar, A, Pordes, S, Poudel, S, Pugachev, D, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Reinhold, B, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Savarese, C, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zuzel, G, Agnes P., Albuquerque I. F. M., Alexander T., Alton A. K., Araujo G. R., Ave M., Back H. O., Baldin B., Batignani G., Biery K., Bocci V., Bonfini G., Bonivento W., Bottino B., Budano F., Bussino S., Cadeddu M., Cadoni M., Calaprice F., Caminata A., Canci N., Candela A., Caravati M., Cariello M., Carlini M., Carpinelli M., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Chepurnov A., Cicalo C., Cocco A. G., Covone G., D'Angelo D., D'Incecco M., D'Urso D., Davini S., De Candia A., De Cecco S., De Deo M., De Filippis G., De Rosa G., De Vincenzi M., Derbin A. V., Devoto A., Di Eusanio F., Di Pietro G., Dionisi C., Downing M., Edkins E., Empl A., Fan A., Fiorillo G., Fitzpatrick R. S., Fomenko K., Franco D., Gabriele F., Galbiati C., Ghiano C., Giagu S., Giganti C., Giovanetti G. K., Gorchakov O., Goretti A. M., Granato F., Gromov M., Guan M., Guardincerri Y., Gulino M., Hackett B. R., Herner K., Hosseini B., Hughes D., Humble P., Hungerford E. V., Ianni A., Ippolito V., James I., Johnson T. N., Keeter K., Kendziora C. L., Kochanek I., Koh G., Korablev D., Korga G., Kubankin A., Kuss M., La Commara M., Lai M., Li X., Lissia M., Longo G., Ma Y., Machado A. A., Machulin I. N., Mandarano A., Mapelli L., Mari S. M., Maricic J., Martoff C. J., Messina A., Meyers P. D., Milincic R., Monte A., Morrocchi M., Mount B. J., Muratova V. N., Musico P., Navrer Agasson A., Nozdrina A. O., Oleinik A., Orsini M., Ortica F., Pagani L., Pallavicini M., Pandola L., Pantic E., Paoloni E., Pelczar K., Pelliccia N., Pocar A., Pordes S., Poudel S. S., Pugachev D. A., Qian H., Ragusa F., Razeti M., Razeto A., Reinhold B., Renshaw A. L., Rescigno M., Riffard Q., Romani A., Rossi B., Rossi N., Sablone D., Samoylov O., Sands W., Sanfilippo S., Savarese C., Schlitzer B., Segreto E., Semenov D. A., Shchagin A., Sheshukov A., Singh P. N., Skorokhvatov M. D., Smirnov O., Sotnikov A., Stanford C., Stracka S., Suvorov Y., Tartaglia R., Testera G., Tonazzo A., Trinchese P., Unzhakov E. V., Verducci M., Vishneva A., Vogelaar B., Wada M., Waldrop T. J., Wang H., Wang Y., Watson A. W., Westerdale S., Wojcik M. M., Xiang X., Xiao X., Yang C., Ye Z., Zhu C., and Zuzel G.
Abstract: The DarkSide-50 direct-detection dark matter experiment is a dual-phase argon time projection chamber operating at Laboratori Nazionali del Gran Sasso. This paper reports on the blind analysis of a (16 660±270) kg d exposure using a target of low-radioactivity argon extracted from underground sources. We find no events in the dark matter selection box and set a 90% C.L. upper limit on the dark matter-nucleon spin-independent cross section of 1.14×10-44 cm2 (3.78×10-44 cm2, 3.43×10-43 cm2) for a WIMP mass of 100 GeV/c2 (1 TeV/c2, 10 TeV/c2).
Published: 2018

42. Constraints on Sub-GeV Dark-Matter-Electron Scattering from the DarkSide-50 Experiment

Author: Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Araujo, G, Asner, D, Ave, M, Back, H, Baldin, B, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Budano, F, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Cereseto, R, Chepurnov, A, Cicalò, C, Cifarelli, L, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, De Vincenzi, M, Demontis, P, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Downing, M, Edkins, E, Empl, A, Fan, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Gabrieli, A, Galbiati, C, Garcia Abia, P, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Hassanshahi, M, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, James, I, Johnson, T, Kahn, Y, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, La Commara, M, Lai, M, Li, X, Lisanti, M, Lissia, M, Loer, B, Longo, G, Ma, Y, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Mishra-Sharma, S, Monte, A, Morrocchi, M, Mount, B, Muratova, V, Musico, P, Nania, R, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pazzona, F, Pelczar, K, Pelliccia, N, Pesudo, V, Picciau, E, Pocar, A, Pordes, S, Poudel, S, Pugachev, D, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Reinhold, B, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Sant, M, Santorelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suffritti, G, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zichichi, A, Zuzel, G, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Araujo, G. R., Asner, D. M., Ave, M., Back, H. O., Baldin, B., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bottino, B., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Cereseto, R., Chepurnov, A., Cicalò, C., Cifarelli, L., Cocco, A. G., Covone, G., D'Angelo, D., D'Incecco, M., D'Urso, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., De Vincenzi, M., Demontis, P., Derbin, A. V., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Downing, M., Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Gabrieli, A., Galbiati, C., Garcia Abia, P., Ghiano, C., Giagu, S., Giganti, C., Giovanetti, G. K., Gorchakov, O., Goretti, A. M., Granato, F., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B. R., Hassanshahi, M. H., Herner, K., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, Al., Ianni, An., Ippolito, V., James, I., Johnson, T. N., Kahn, Y., Keeter, K., Kendziora, C. L., Kochanek, I., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lisanti, M., Lissia, M., Loer, B., Longo, G., Ma, Y., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Mari, S. M., Maricic, J., Martoff, C. J., Messina, A., Meyers, P. D., Milincic, R., Mishra-Sharma, S., Monte, A., Morrocchi, M., Mount, B. J., Muratova, V. N., Musico, P., Nania, R., Navrer Agasson, A., Nozdrina, A. O., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pazzona, F., Pelczar, K., Pelliccia, N., Pesudo, V., Picciau, E., Pocar, A., Pordes, S., Poudel, S. S., Pugachev, D. A., Qian, H., Ragusa, F., Razeti, M., Razeto, A., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Sant, M., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Segreto, E., Semenov, D. A., Shchagin, A., Sheshukov, A., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Stracka, S., Suffritti, G. B., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Waldrop, T. J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Wojcik, M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., Zichichi, A., Zuzel, G., Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Araujo, G, Asner, D, Ave, M, Back, H, Baldin, B, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Budano, F, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Cereseto, R, Chepurnov, A, Cicalò, C, Cifarelli, L, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, De Vincenzi, M, Demontis, P, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Downing, M, Edkins, E, Empl, A, Fan, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Gabrieli, A, Galbiati, C, Garcia Abia, P, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Hassanshahi, M, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, James, I, Johnson, T, Kahn, Y, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, La Commara, M, Lai, M, Li, X, Lisanti, M, Lissia, M, Loer, B, Longo, G, Ma, Y, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Mishra-Sharma, S, Monte, A, Morrocchi, M, Mount, B, Muratova, V, Musico, P, Nania, R, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pazzona, F, Pelczar, K, Pelliccia, N, Pesudo, V, Picciau, E, Pocar, A, Pordes, S, Poudel, S, Pugachev, D, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Reinhold, B, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Sant, M, Santorelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suffritti, G, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zichichi, A, Zuzel, G, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Araujo, G. R., Asner, D. M., Ave, M., Back, H. O., Baldin, B., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bottino, B., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Cereseto, R., Chepurnov, A., Cicalò, C., Cifarelli, L., Cocco, A. G., Covone, G., D'Angelo, D., D'Incecco, M., D'Urso, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., De Vincenzi, M., Demontis, P., Derbin, A. V., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Downing, M., Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Gabrieli, A., Galbiati, C., Garcia Abia, P., Ghiano, C., Giagu, S., Giganti, C., Giovanetti, G. K., Gorchakov, O., Goretti, A. M., Granato, F., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B. R., Hassanshahi, M. H., Herner, K., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, Al., Ianni, An., Ippolito, V., James, I., Johnson, T. N., Kahn, Y., Keeter, K., Kendziora, C. L., Kochanek, I., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lisanti, M., Lissia, M., Loer, B., Longo, G., Ma, Y., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Mari, S. M., Maricic, J., Martoff, C. J., Messina, A., Meyers, P. D., Milincic, R., Mishra-Sharma, S., Monte, A., Morrocchi, M., Mount, B. J., Muratova, V. N., Musico, P., Nania, R., Navrer Agasson, A., Nozdrina, A. O., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pazzona, F., Pelczar, K., Pelliccia, N., Pesudo, V., Picciau, E., Pocar, A., Pordes, S., Poudel, S. S., Pugachev, D. A., Qian, H., Ragusa, F., Razeti, M., Razeto, A., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Sant, M., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Segreto, E., Semenov, D. A., Shchagin, A., Sheshukov, A., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Stracka, S., Suffritti, G. B., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Waldrop, T. J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Wojcik, M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., Zichichi, A., and Zuzel, G.
Abstract: We present new constraints on sub-GeV dark-matter particles scattering off electrons based on 6780.0 kg d of data collected with the DarkSide-50 dual-phase argon time projection chamber. This analysis uses electroluminescence signals due to ionized electrons extracted from the liquid argon target. The detector has a very high trigger probability for these signals, allowing for an analysis threshold of three extracted electrons, or approximately 0.05 keVee. We calculate the expected recoil spectra for dark matter-electron scattering in argon and, under the assumption of momentum-independent scattering, improve upon existing limits from XENON10 for dark-matter particles with masses between 30 and 100 MeV/c2.
Published: 2018

43. Low-mass dark matter search with the DarkSide-50 experiment

Author: Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Araujo, G, Asner, D, Ave, M, Back, H, Baldin, B, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Budano, F, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Cereseto, R, Chepurnov, A, Cicalò, C, Cifarelli, L, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, De Vincenzi, M, Demontis, P, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Downing, M, Edkins, E, Empl, A, Fan, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Gabrieli, A, Galbiati, C, Garcia Abia, P, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Hassanshahi, M, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, James, I, Johnson, T, Kahn, Y, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, La Commara, M, Lai, M, Li, X, Lisanti, M, Lissia, M, Loer, B, Longo, G, Ma, Y, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Mishra-Sharma, S, Monte, A, Morrocchi, M, Mount, B, Muratova, V, Musico, P, Nania, R, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pazzona, F, Pelczar, K, Pelliccia, N, Pesudo, V, Pocar, A, Pordes, S, Poudel, S, Pugachev, D, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Reinhold, B, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Sant, M, Santorelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suffritti, G, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zichichi, A, Zuzel, G, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Araujo, G. R., Asner, D. M., Ave, M., Back, H. O., Baldin, B., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bottino, B., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Cereseto, R., Chepurnov, A., Cicalò, C., Cifarelli, L., Cocco, A. G., Covone, G., D'Angelo, D., D'Incecco, M., D'Urso, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., De Vincenzi, M., Demontis, P., Derbin, A. V., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Downing, M., Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Gabrieli, A., Galbiati, C., Garcia Abia, P., Ghiano, Chiara, Giagu, S., Giganti, C., Giovanetti, G. K., Gorchakov, O., Goretti, A. M., Granato, F., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B. R., Hassanshahi, M. H., Herner, K., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, Al., Ianni, An., Ippolito, V., James, I., Johnson, T. N., Kahn, Y., Keeter, K., Kendziora, C. L., Kochanek, I., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lisanti, M., Lissia, M., Loer, B., Longo, G., Ma, Y., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Mari, S. M., Maricic, J., Martoff, C. J., Messina, A., Meyers, P. D., Milincic, R., Mishra-Sharma, S., Monte, A., Morrocchi, M., Mount, B. J., Muratova, V. N., Musico, P., Nania, R., Navrer Agasson, A., Nozdrina, A. O., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pazzona, F., Pelczar, K., Pelliccia, N., Pesudo, V., Pocar, A., Pordes, S., Poudel, S. S., Pugachev, D. A., Qian, H., Ragusa, F., Razeti, M., Razeto, A., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Sant, M., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Segreto, E., Semenov, D. A., Shchagin, A., Sheshukov, A., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Stracka, S., Suffritti, G. B., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Waldrop, T. J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Wojcik, M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., Zichichi, A., Zuzel, G., Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Araujo, G, Asner, D, Ave, M, Back, H, Baldin, B, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Budano, F, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Cereseto, R, Chepurnov, A, Cicalò, C, Cifarelli, L, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, De Vincenzi, M, Demontis, P, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Downing, M, Edkins, E, Empl, A, Fan, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Gabrieli, A, Galbiati, C, Garcia Abia, P, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Hassanshahi, M, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, James, I, Johnson, T, Kahn, Y, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, La Commara, M, Lai, M, Li, X, Lisanti, M, Lissia, M, Loer, B, Longo, G, Ma, Y, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Mishra-Sharma, S, Monte, A, Morrocchi, M, Mount, B, Muratova, V, Musico, P, Nania, R, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pazzona, F, Pelczar, K, Pelliccia, N, Pesudo, V, Pocar, A, Pordes, S, Poudel, S, Pugachev, D, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Reinhold, B, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Sant, M, Santorelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suffritti, G, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zichichi, A, Zuzel, G, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Araujo, G. R., Asner, D. M., Ave, M., Back, H. O., Baldin, B., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bottino, B., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Cereseto, R., Chepurnov, A., Cicalò, C., Cifarelli, L., Cocco, A. G., Covone, G., D'Angelo, D., D'Incecco, M., D'Urso, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., De Vincenzi, M., Demontis, P., Derbin, A. V., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Downing, M., Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Gabrieli, A., Galbiati, C., Garcia Abia, P., Ghiano, Chiara, Giagu, S., Giganti, C., Giovanetti, G. K., Gorchakov, O., Goretti, A. M., Granato, F., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B. R., Hassanshahi, M. H., Herner, K., Hosseini, B., Hughes, D., Humble, P., Hungerford, E. V., Ianni, Al., Ianni, An., Ippolito, V., James, I., Johnson, T. N., Kahn, Y., Keeter, K., Kendziora, C. L., Kochanek, I., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lisanti, M., Lissia, M., Loer, B., Longo, G., Ma, Y., Machado, A. A., Machulin, I. N., Mandarano, A., Mapelli, L., Mari, S. M., Maricic, J., Martoff, C. J., Messina, A., Meyers, P. D., Milincic, R., Mishra-Sharma, S., Monte, A., Morrocchi, M., Mount, B. J., Muratova, V. N., Musico, P., Nania, R., Navrer Agasson, A., Nozdrina, A. O., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pazzona, F., Pelczar, K., Pelliccia, N., Pesudo, V., Pocar, A., Pordes, S., Poudel, S. S., Pugachev, D. A., Qian, H., Ragusa, F., Razeti, M., Razeto, A., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Sant, M., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Segreto, E., Semenov, D. A., Shchagin, A., Sheshukov, A., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Stracka, S., Suffritti, G. B., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Waldrop, T. J., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Wojcik, M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., Zichichi, A., and Zuzel, G.
Abstract: We present the results of a search for dark matter weakly interacting massive particles (WIMPs) in the mass range below 20 GeV=c2 using a target of low-radioactivity argon with a 6786.0 kg d exposure. The data were obtained using the DarkSide-50 apparatus at Laboratori Nazionali del Gran Sasso. The analysis is based on the ionization signal, for which the DarkSide-50 time projection chamber is fully efficient at 0.1 keVee. The observed rate in the detector at 0.5 keVee is about 1.5 event=keVee=kg=d and is almost entirely accounted for by known background sources. We obtain a 90% C.L. exclusion limit above 1.8 GeV=c2 for the spin-independent cross section of dark matter WIMPs on nucleons, extending the exclusion region for dark matter below previous limits in the range 1.8-6 GeV=c2.
Published: 2018

44. Electroluminescence pulse shape and electron diffusion in liquid argon measured in a dual-phase TPC

Author: Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Asner, D, Ave, M, Back, H, Baldin, B, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bossa, M, Bottino, B, Budano, F, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalò, C, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, De Vincenzi, M, Demontis, P, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Edkins, E, Fan, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Gabrieli, A, Galbiati, C, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Herner, K, Hughes, D, Humble, P, Hungerford, E, Ianni, A, James, I, Johnson, T, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, Li, X, Lissia, M, Loer, B, Longo, G, Ma, Y, Machado, A, Machulin, I, Mandarano, A, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Monte, A, Morrocchi, M, Mount, B, Muratova, V, Musico, P, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pazzona, F, Pelczar, K, Pelliccia, N, Pocar, A, Pordes, S, Qian, H, Razeti, M, Razeto, A, Reinhold, B, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Sant, M, Savarese, C, Schlitzer, B, Segreto, E, Semenov, D, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Suffritti, G, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Walker, S, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zuzel, G, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Asner, D. M., Ave, M. P., Back, H. O., Baldin, B., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bossa, M., Bottino, B., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Chepurnov, A., Cicalò, C., Cocco, A. G., Covone, G., D'Angelo, D., D'Incecco, M., D'Urso, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., De Vincenzi, M., Demontis, P., Derbin, A. V., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Edkins, E., Fan, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Gabrieli, A., Galbiati, C., Ghiano, C., Giagu, S., Giganti, C., Giovanetti, G. K., Goretti, A. M., Granato, F., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B. R., Herner, K., Hughes, D., Humble, P., Hungerford, E. V., Ianni, An., James, I., Johnson, T. N., Keeter, K., Kendziora, C. L., Kochanek, I., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., Li, X., Lissia, M., Loer, B., Longo, G., Ma, Y., Machado, A. A., Machulin, I. N., Mandarano, A., Mari, S. M., Maricic, J., Martoff, C. J., Messina, A., Meyers, P. D., Milincic, R., Monte, A., Morrocchi, M., Mount, B. J., Muratova, V. N., Musico, P., Navrer Agasson, A., Nozdrina, A., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pazzona, F., Pelczar, K., Pelliccia, N., Pocar, A., Pordes, S., Qian, H., Razeti, M., Razeto, A., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Sant, M., Savarese, C., Schlitzer, B., Segreto, E., Semenov, D. A., Sheshukov, A., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Suffritti, G. B., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Waldrop, T. J., Walker, S., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., Zuzel, G., Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Asner, D, Ave, M, Back, H, Baldin, B, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bossa, M, Bottino, B, Budano, F, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalò, C, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davini, S, De Candia, A, De Cecco, S, De Deo, M, De Filippis, G, De Rosa, G, De Vincenzi, M, Demontis, P, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Edkins, E, Fan, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Gabrieli, A, Galbiati, C, Ghiano, C, Giagu, S, Giganti, C, Giovanetti, G, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Herner, K, Hughes, D, Humble, P, Hungerford, E, Ianni, A, James, I, Johnson, T, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, Li, X, Lissia, M, Loer, B, Longo, G, Ma, Y, Machado, A, Machulin, I, Mandarano, A, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Monte, A, Morrocchi, M, Mount, B, Muratova, V, Musico, P, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pazzona, F, Pelczar, K, Pelliccia, N, Pocar, A, Pordes, S, Qian, H, Razeti, M, Razeto, A, Reinhold, B, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Sant, M, Savarese, C, Schlitzer, B, Segreto, E, Semenov, D, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Suffritti, G, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Walker, S, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zuzel, G, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Asner, D. M., Ave, M. P., Back, H. O., Baldin, B., Batignani, G., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bossa, M., Bottino, B., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Candela, A., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavuoti, S., Chepurnov, A., Cicalò, C., Cocco, A. G., Covone, G., D'Angelo, D., D'Incecco, M., D'Urso, D., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, G., De Vincenzi, M., Demontis, P., Derbin, A. V., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Edkins, E., Fan, A., Fiorillo, G., Fomenko, K., Franco, D., Gabriele, F., Gabrieli, A., Galbiati, C., Ghiano, C., Giagu, S., Giganti, C., Giovanetti, G. K., Goretti, A. M., Granato, F., Gromov, M., Guan, M., Guardincerri, Y., Gulino, M., Hackett, B. R., Herner, K., Hughes, D., Humble, P., Hungerford, E. V., Ianni, An., James, I., Johnson, T. N., Keeter, K., Kendziora, C. L., Kochanek, I., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M., Li, X., Lissia, M., Loer, B., Longo, G., Ma, Y., Machado, A. A., Machulin, I. N., Mandarano, A., Mari, S. M., Maricic, J., Martoff, C. J., Messina, A., Meyers, P. D., Milincic, R., Monte, A., Morrocchi, M., Mount, B. J., Muratova, V. N., Musico, P., Navrer Agasson, A., Nozdrina, A., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pazzona, F., Pelczar, K., Pelliccia, N., Pocar, A., Pordes, S., Qian, H., Razeti, M., Razeto, A., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Sant, M., Savarese, C., Schlitzer, B., Segreto, E., Semenov, D. A., Sheshukov, A., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Suffritti, G. B., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, B., Wada, M., Waldrop, T. J., Walker, S., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Xiang, X., Xiao, X., Yang, C., Ye, Z., Zhu, C., and Zuzel, G.
Abstract: We report the measurement of the longitudinal diffusion constant in liquid argon with the DarkSide-50 dual-phase time projection chamber. The measurement is performed at drift electric fields of 100 V/cm, 150 V/cm, and 200 V/cm using high statistics 39Ar decays from atmospheric argon. We derive an expression to describe the pulse shape of the electroluminescence signal (S2) in dual-phase TPCs. The derived S2 pulse shape is fit to events from the uppermost portion of the TPC in order to characterize the radial dependence of the signal. The results are provided as inputs to the measurement of the longitudinal diffusion constant DL, which we find to be (4.12 ± 0.09) cm2/s for a selection of 140 keV electron recoil events in 200 V/cm drift field and 2.8 kV/cm extraction field. To study the systematics of our measurement we examine data sets of varying event energy, field strength, and detector volume yielding a weighted average value for the diffusion constant of (4.09 ± 0.12) cm2/s. The measured longitudinal diffusion constant is observed to have an energy dependence, and within the studied energy range the result is systematically lower than other results in the literature.
Published: 2018

45. New physics results from darkside-50

Author: Auge, E, Dumarchez, J, Tron Thanh Van, J, Franco, D, Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Araujo, G, Asner, D, Ave, M, Back, H, Baldin, B, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Budano, F, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cifarelli, L, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davini, S, de Candia, A, de Cecco, S, de Deo, M, de Filippis, G, de Rosa, G, de Vincenzi, M, Demontis, P, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Downing, M, Edkins, E, Empl, A, Fan, A, Fiorillo, G, Fomenko, K, Gabriele, F, Gabrieli, A, Galbiati, C, Garcia Abia, P, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Hassanshahi, M, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, James, I, Johnson, T, Kahn, Y, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, la Commara, M, Lai, M, Li, X, Lisanti, M, Lissia, M, Loer, B, Longo, G, Ma, Y, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Mishra-Sharma, S, Monte, A, Morrocchi, M, Mount, B, Muratova, V, Musico, P, Nania, R, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pazzona, F, Pelczar, K, Pelliccia, N, Pesudo, V, Pocar, A, Pordes, S, Poudel, S, Pugachev, D, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Reinhold, B, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Sant, M, Santorelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suffritti, G, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zichichi, A, Zuzel, G, Franco D., Agnes P., Albuquerque I. F. M., Alexander T., Alton A. K., Araujo G. R., Asner D. M., Ave M. P., Back H. O., Baldin B., Batignani G., Biery K., Bocci V., Bonfini G., Bonivento W., Bottino B., Budano F., Bussino S., Cadeddu M., Cadoni M., Calaprice F., Caminata A., Canci N., Candela A., Caravati M., Cariello M., Carlini M., Carpinelli M., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Chepurnov A., Cicalo C., Cifarelli L., Cocco A. G., Covone G., D'Angelo D., D'Incecco M., D'Urso D., Davini S., de Candia A., de Cecco S., de Deo M., de Filippis G., de Rosa G., de Vincenzi M., Demontis P., Derbin A. V., Devoto A., Di Eusanio F., Di Pietro G., Dionisi C., Downing M., Edkins E., Empl A., Fan A., Fiorillo G., Fomenko K., Gabriele F., Gabrieli A., Galbiati C., Garcia Abia P., Giagu S., Giganti C., Giovanetti G. K., Gorchakov O., Goretti A. M., Granato F., Gromov M., Guan M., Guardincerri Y., Gulino M., Hackett B. R., Hassanshahi M. H., Herner K., Hosseini B., Hughes D., Humble P., Hungerford E. V., Ianni Al., Ianni An., Ippolito V., James I., Johnson T. N., Kahn Y., Keeter K., Kendziora C. L., Kochanek I., Koh G., Korablev D., Korga G., Kubankin A., Kuss M., la Commara M., Lai M., Li X., Lisanti M., Lissia M., Loer B., Longo G., Ma Y., Machado A. A., Machulin I. N., Mandarano A., Mapelli L., Mari S. M., Maricic J., Martoff C. J., Messina A., Meyers P. D., Milincic R., Mishra-Sharma S., Monte A., Morrocchi M., Mount B. J., Muratova V. N., Musico P., Nania R., Navrer Agasson A., Nozdrina A. O., Oleinik A., Orsini M., Ortica F., Pagani L., Pallavicini M., Pandola L., Pantic E., Paoloni E., Pazzona F., Pelczar K., Pelliccia N., Pesudo V., Pocar A., Pordes S., Poudel S. S., Pugachev D. A., Qian H., Ragusa F., Razeti M., Razeto A., Reinhold B., Renshaw A. L., Rescigno M., Riffard Q., Romani A., Rossi B., Rossi N., Sablone D., Samoylov O., Sands W., Sanfilippo S., Sant M., Santorelli R., Savarese C., Scapparone E., Schlitzer B., Segreto E., Semenov D. A., Shchagin A., Sheshukov A., Singh P. N., Skorokhvatov M. D., Smirnov O., Sotnikov A., Stanford C., Stracka S., Suffritti G. B., Suvorov Y., Tartaglia R., Testera G., Tonazzo A., Trinchese P., Unzhakov E. V., Verducci M., Vishneva A., Vogelaar B., Wada M., Waldrop T. J., Wang H., Wang Y., Watson A. W., Westerdale S., Wojcik M. M., Wojcik M., Xiang X., Xiao X., Yang C., Ye Z., Zhu C., Zichichi A., Zuzel G., Auge, E, Dumarchez, J, Tron Thanh Van, J, Franco, D, Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Araujo, G, Asner, D, Ave, M, Back, H, Baldin, B, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Budano, F, Bussino, S, Cadeddu, M, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cifarelli, L, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davini, S, de Candia, A, de Cecco, S, de Deo, M, de Filippis, G, de Rosa, G, de Vincenzi, M, Demontis, P, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Downing, M, Edkins, E, Empl, A, Fan, A, Fiorillo, G, Fomenko, K, Gabriele, F, Gabrieli, A, Galbiati, C, Garcia Abia, P, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Hassanshahi, M, Herner, K, Hosseini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, James, I, Johnson, T, Kahn, Y, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, la Commara, M, Lai, M, Li, X, Lisanti, M, Lissia, M, Loer, B, Longo, G, Ma, Y, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Mishra-Sharma, S, Monte, A, Morrocchi, M, Mount, B, Muratova, V, Musico, P, Nania, R, Navrer Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paoloni, E, Pazzona, F, Pelczar, K, Pelliccia, N, Pesudo, V, Pocar, A, Pordes, S, Poudel, S, Pugachev, D, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Reinhold, B, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Sant, M, Santorelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suffritti, G, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zichichi, A, Zuzel, G, Franco D., Agnes P., Albuquerque I. F. M., Alexander T., Alton A. K., Araujo G. R., Asner D. M., Ave M. P., Back H. O., Baldin B., Batignani G., Biery K., Bocci V., Bonfini G., Bonivento W., Bottino B., Budano F., Bussino S., Cadeddu M., Cadoni M., Calaprice F., Caminata A., Canci N., Candela A., Caravati M., Cariello M., Carlini M., Carpinelli M., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Chepurnov A., Cicalo C., Cifarelli L., Cocco A. G., Covone G., D'Angelo D., D'Incecco M., D'Urso D., Davini S., de Candia A., de Cecco S., de Deo M., de Filippis G., de Rosa G., de Vincenzi M., Demontis P., Derbin A. V., Devoto A., Di Eusanio F., Di Pietro G., Dionisi C., Downing M., Edkins E., Empl A., Fan A., Fiorillo G., Fomenko K., Gabriele F., Gabrieli A., Galbiati C., Garcia Abia P., Giagu S., Giganti C., Giovanetti G. K., Gorchakov O., Goretti A. M., Granato F., Gromov M., Guan M., Guardincerri Y., Gulino M., Hackett B. R., Hassanshahi M. H., Herner K., Hosseini B., Hughes D., Humble P., Hungerford E. V., Ianni Al., Ianni An., Ippolito V., James I., Johnson T. N., Kahn Y., Keeter K., Kendziora C. L., Kochanek I., Koh G., Korablev D., Korga G., Kubankin A., Kuss M., la Commara M., Lai M., Li X., Lisanti M., Lissia M., Loer B., Longo G., Ma Y., Machado A. A., Machulin I. N., Mandarano A., Mapelli L., Mari S. M., Maricic J., Martoff C. J., Messina A., Meyers P. D., Milincic R., Mishra-Sharma S., Monte A., Morrocchi M., Mount B. J., Muratova V. N., Musico P., Nania R., Navrer Agasson A., Nozdrina A. O., Oleinik A., Orsini M., Ortica F., Pagani L., Pallavicini M., Pandola L., Pantic E., Paoloni E., Pazzona F., Pelczar K., Pelliccia N., Pesudo V., Pocar A., Pordes S., Poudel S. S., Pugachev D. A., Qian H., Ragusa F., Razeti M., Razeto A., Reinhold B., Renshaw A. L., Rescigno M., Riffard Q., Romani A., Rossi B., Rossi N., Sablone D., Samoylov O., Sands W., Sanfilippo S., Sant M., Santorelli R., Savarese C., Scapparone E., Schlitzer B., Segreto E., Semenov D. A., Shchagin A., Sheshukov A., Singh P. N., Skorokhvatov M. D., Smirnov O., Sotnikov A., Stanford C., Stracka S., Suffritti G. B., Suvorov Y., Tartaglia R., Testera G., Tonazzo A., Trinchese P., Unzhakov E. V., Verducci M., Vishneva A., Vogelaar B., Wada M., Waldrop T. J., Wang H., Wang Y., Watson A. W., Westerdale S., Wojcik M. M., Wojcik M., Xiang X., Xiao X., Yang C., Ye Z., Zhu C., Zichichi A., and Zuzel G.
Abstract: DarkSide-50 is dual-phase liquid argon time projection chamber designed for WIMP search and installed at Gran Sasso underground laboratory. We present new constraints on dark matter particles scattering off nuclei and electrons from a 532.4 live-days exposure.
Published: 2018

46. DarkSide new results and prospects

Author: Cadeddu, M, Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Araujo, G, Asner, D, Ave, M, Back, H, Baldin, B, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Budano, F, Bussino, S, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cifarelli, L, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davin, S, de Candia, A, de Cecco, S, de Deo, M, de Filippis, G, de Rosa, G, de Vincenzi, M, Demontis, P, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Downing, M, Edkins, E, Empl, A, Fan, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Gabrieli, A, Galbiati, C, Abia, P, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Hassanshahi, M, Herner, K, Hos-Seini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, James, I, Johnson, T, Kahn, Y, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, la Commara, M, Lai, M, Li, X, Lisanti, M, Lissia, M, Loer, B, Longo, G, Ma, Y, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Mishra-Sharma, S, Monte, A, Morrocchi, M, Mount, B, Muratova, V, Musico, P, Nania, R, Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paolon, E, Pazzona, F, Pelczar, K, Pelliccia, N, Pesudo, V, Picciau, E, Pocar, A, Pordes, S, Poudel, S, Pugachev, D, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Reinhold, B, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Sant, M, Santorelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suffritti, G, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zichichi, A, Zuzel, G, Cadeddu M., Agnes P., Albuquerque I. F. M., Alexander T., Alton A. K., Araujo G. R., Asner D. M., Ave M. P., Back H. O., Baldin B., Batignani G., Biery K., Bocci V., Bonfini G., Bonivento W., Bottino B., Budano F., Bussino S., Cadoni M., Calaprice F., Caminata A., Canci N., Candela A., Caravati M., Cariello M., Carlini M., Carpinelli M., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Chepurnov A., Cicalo C., Cifarelli L., Cocco A. G., Covone G., D'Angelo D., D'Incecco M., D'Urso D., Davin S., de Candia A., de Cecco S., de Deo M., de Filippis G., de Rosa G., de Vincenzi M., Demontis P., Derbin A. V., Devoto A., Di Eusanio F., Di Pietro G., Dionisi C., Downing M., Edkins E., Empl A., Fan A., Fiorillo G., Fomenko K., Franco D., Gabriele F., Gabrieli A., Galbiati C., Abia P. G., Giagu S., Giganti C., Giovanetti G. K., Gorchakov O., Goretti A. M., Granato F., Gromov M., Guan M., Guardincerri Y., Gulino M., Hackett B. R., Hassanshahi M. H., Herner K., Hos-Seini B., Hughes D., Humble P., Hungerford E. V., Ianni Al., Ianni An., Ippolito V., James I., Johnson T. N., Kahn Y., Keeter K., Kendziora C. L., Kochanek I., Koh G., Korablev D., Korga G., Kubankin A., Kuss M., la Commara M., Lai M., Li X., Lisanti M., Lissia M., Loer B., Longo G., Ma Y., Machado A. A., Machulin I. N., Mandarano A., Mapelli L., Mari S. M., Maricic J., Martoff C. J., Messina A., Meyers P. D., Milincic R., Mishra-Sharma S., Monte A., Morrocchi M., Mount B. J., Muratova V. N., Musico P., Nania R., Agasson A. N., Nozdrina A. O., Oleinik A., Orsini M., Ortica F., Pagani L., Pallavicini M., Pandola L., Pantic E., Paolon E., Pazzona F., Pelczar K., Pelliccia N., Pesudo V., Picciau E., Pocar A., Pordes S., Poudel S. S., Pugachev D. A., Qian H., Ragusa F., Razeti M., Razeto A., Reinhold B., Renshaw A. L., Rescigno M., Riffard Q., Romani A., Rossi B., Rossi N., Sablone D., Samoylov O., Sands W., Sanfilippo S., Sant M., Santorelli R., Savarese C., Scapparone E., Schlitzer B., Segreto E., Semenov D. A., Shchagin A., Sheshukov A., Singh P. N., Skorokhvatov M. D., Smirnov O., Sotnikov A., Stanford C., Stracka S., Suffritti G. B., Suvorov Y., Tartaglia R., Testera G., Tonazzo A., Trinchese P., Unzhakov E. V., Verducci M., Vishneva A., Vogelaar B., Wada M., Waldrop T. J., Wang H., Wang Y., Watson A. W., Westerdale S., Wojcik M. M., Wojcik M., Xiang X., Xiao X., Yang C., Ye Z., Zhu C., Zichichi A., Zuzel G., Cadeddu, M, Agnes, P, Albuquerque, I, Alexander, T, Alton, A, Araujo, G, Asner, D, Ave, M, Back, H, Baldin, B, Batignani, G, Biery, K, Bocci, V, Bonfini, G, Bonivento, W, Bottino, B, Budano, F, Bussino, S, Cadoni, M, Calaprice, F, Caminata, A, Canci, N, Candela, A, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Catalanotti, S, Cataudella, V, Cavalcante, P, Cavuoti, S, Chepurnov, A, Cicalo, C, Cifarelli, L, Cocco, A, Covone, G, D'Angelo, D, D'Incecco, M, D'Urso, D, Davin, S, de Candia, A, de Cecco, S, de Deo, M, de Filippis, G, de Rosa, G, de Vincenzi, M, Demontis, P, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Downing, M, Edkins, E, Empl, A, Fan, A, Fiorillo, G, Fomenko, K, Franco, D, Gabriele, F, Gabrieli, A, Galbiati, C, Abia, P, Giagu, S, Giganti, C, Giovanetti, G, Gorchakov, O, Goretti, A, Granato, F, Gromov, M, Guan, M, Guardincerri, Y, Gulino, M, Hackett, B, Hassanshahi, M, Herner, K, Hos-Seini, B, Hughes, D, Humble, P, Hungerford, E, Ianni, A, Ippolito, V, James, I, Johnson, T, Kahn, Y, Keeter, K, Kendziora, C, Kochanek, I, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, la Commara, M, Lai, M, Li, X, Lisanti, M, Lissia, M, Loer, B, Longo, G, Ma, Y, Machado, A, Machulin, I, Mandarano, A, Mapelli, L, Mari, S, Maricic, J, Martoff, C, Messina, A, Meyers, P, Milincic, R, Mishra-Sharma, S, Monte, A, Morrocchi, M, Mount, B, Muratova, V, Musico, P, Nania, R, Agasson, A, Nozdrina, A, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Pandola, L, Pantic, E, Paolon, E, Pazzona, F, Pelczar, K, Pelliccia, N, Pesudo, V, Picciau, E, Pocar, A, Pordes, S, Poudel, S, Pugachev, D, Qian, H, Ragusa, F, Razeti, M, Razeto, A, Reinhold, B, Renshaw, A, Rescigno, M, Riffard, Q, Romani, A, Rossi, B, Rossi, N, Sablone, D, Samoylov, O, Sands, W, Sanfilippo, S, Sant, M, Santorelli, R, Savarese, C, Scapparone, E, Schlitzer, B, Segreto, E, Semenov, D, Shchagin, A, Sheshukov, A, Singh, P, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Stanford, C, Stracka, S, Suffritti, G, Suvorov, Y, Tartaglia, R, Testera, G, Tonazzo, A, Trinchese, P, Unzhakov, E, Verducci, M, Vishneva, A, Vogelaar, B, Wada, M, Waldrop, T, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wojcik, M, Xiang, X, Xiao, X, Yang, C, Ye, Z, Zhu, C, Zichichi, A, Zuzel, G, Cadeddu M., Agnes P., Albuquerque I. F. M., Alexander T., Alton A. K., Araujo G. R., Asner D. M., Ave M. P., Back H. O., Baldin B., Batignani G., Biery K., Bocci V., Bonfini G., Bonivento W., Bottino B., Budano F., Bussino S., Cadoni M., Calaprice F., Caminata A., Canci N., Candela A., Caravati M., Cariello M., Carlini M., Carpinelli M., Catalanotti S., Cataudella V., Cavalcante P., Cavuoti S., Chepurnov A., Cicalo C., Cifarelli L., Cocco A. G., Covone G., D'Angelo D., D'Incecco M., D'Urso D., Davin S., de Candia A., de Cecco S., de Deo M., de Filippis G., de Rosa G., de Vincenzi M., Demontis P., Derbin A. V., Devoto A., Di Eusanio F., Di Pietro G., Dionisi C., Downing M., Edkins E., Empl A., Fan A., Fiorillo G., Fomenko K., Franco D., Gabriele F., Gabrieli A., Galbiati C., Abia P. G., Giagu S., Giganti C., Giovanetti G. K., Gorchakov O., Goretti A. M., Granato F., Gromov M., Guan M., Guardincerri Y., Gulino M., Hackett B. R., Hassanshahi M. H., Herner K., Hos-Seini B., Hughes D., Humble P., Hungerford E. V., Ianni Al., Ianni An., Ippolito V., James I., Johnson T. N., Kahn Y., Keeter K., Kendziora C. L., Kochanek I., Koh G., Korablev D., Korga G., Kubankin A., Kuss M., la Commara M., Lai M., Li X., Lisanti M., Lissia M., Loer B., Longo G., Ma Y., Machado A. A., Machulin I. N., Mandarano A., Mapelli L., Mari S. M., Maricic J., Martoff C. J., Messina A., Meyers P. D., Milincic R., Mishra-Sharma S., Monte A., Morrocchi M., Mount B. J., Muratova V. N., Musico P., Nania R., Agasson A. N., Nozdrina A. O., Oleinik A., Orsini M., Ortica F., Pagani L., Pallavicini M., Pandola L., Pantic E., Paolon E., Pazzona F., Pelczar K., Pelliccia N., Pesudo V., Picciau E., Pocar A., Pordes S., Poudel S. S., Pugachev D. A., Qian H., Ragusa F., Razeti M., Razeto A., Reinhold B., Renshaw A. L., Rescigno M., Riffard Q., Romani A., Rossi B., Rossi N., Sablone D., Samoylov O., Sands W., Sanfilippo S., Sant M., Santorelli R., Savarese C., Scapparone E., Schlitzer B., Segreto E., Semenov D. A., Shchagin A., Sheshukov A., Singh P. N., Skorokhvatov M. D., Smirnov O., Sotnikov A., Stanford C., Stracka S., Suffritti G. B., Suvorov Y., Tartaglia R., Testera G., Tonazzo A., Trinchese P., Unzhakov E. V., Verducci M., Vishneva A., Vogelaar B., Wada M., Waldrop T. J., Wang H., Wang Y., Watson A. W., Westerdale S., Wojcik M. M., Wojcik M., Xiang X., Xiao X., Yang C., Ye Z., Zhu C., Zichichi A., and Zuzel G.
Abstract: New results on the scattering cross-section between dark matter particles and nuclei and electrons are presented. They are obtained using a live-days exposure of 532.4 days from the DarkSide-50 experiment, which is a dual-phase liquid-argon time projection chamber (LAr TPC) installed at Laboratori Nazionali del Gran Sasso (LNGS). In this paper, the DarkSide-20k experiment, a LAr TPC with an active (fiducial) mass of 23 t (20 t) to be built at LNGS, is also reviewed. Thanks to its exceptionally low instrumental background, DarkSide-20k will be able to exclude cross sections between weakly interacting massive particles (WIMPs) and nuclei at 90% confidence level down to 2.8×10−48 cm2 (1.2×10−47 cm2) for a WIMP mass of 100 GeV/c2 (1 TeV/c2).
Published: 2018

47. HUNTER: precision massive-neutrino search based on a laser cooled atomic source

Author: Martoff, C J, primary, Granato, F, additional, Palmaccio, V, additional, Yu, X, additional, Smith, P F, additional, Hudson, E R, additional, Hamilton, P, additional, Schneider, C, additional, Chang, E, additional, Renshaw, A, additional, Malatino, F, additional, Meyers, P D, additional, and Lamichhane, B, additional
Published: 2021
Full Text: View/download PDF

48. The DarkSide experiment

Author: Bottino, B., E. Aalseth, C., Acconcia, G., Acerbi, F., Agnes, P., Agostino, L., Albuquerque, I.F.M., Alexander, T., Alton, A., Ampudia, P., Ardito, R., Arisaka, K., J. Arnquist, I., M. Asner, D., O. Back, H., Baldin, B., Batignani, G., Biery, K., G. Bisogni, M., Bocci, V., Bondar, A., Bonfini, G., Bonivento, W., Bossa, M., Brigatti, A., Brodsky, J., Budano, F., Bunker, R., Bussino, S., Buttafava, M., Buzulutskov, A., Cadeddu, M., Cadoni, M., Calandri, N., Calaprice, F., Calvo, J., Campajola, L., Canci, N., Candela, A., Cantini, C., Cao, H., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Castellani, A., Catalanotti, S., Cavalcante, P., Chepurnov, A., Cicalò, C., Citterio, M., G. Cocco, A., Corgiolu, S., Covone, G., Crivelli, P., D'Angelo, D., D'Incecco, M., Daniel, M., Davini, S., De Cecco, S., De Deo, M., De Guido, G., De Vincenzi, M., Demontis, P., Derbin, A., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Dolgov, A., Dromia, I., Dussoni, S., Edkins, E., Empl, A., Fan, A., Ferri, A., O. Filip, C., Fiorillo, G., Fomenko, K., Forster, G., Franco, D., E. Froudakis, G., Gabriele, F., Gabrieli, A., Galbiati, C., Gendotti, A., Ghioni, M., Ghisi, A., Giagu, S., Gibertoni, G., Giganti, C., Giorgi, M., K. Giovannetti, G., L. Gligan, M., Gola, A., Goretti, A., Granato, F., Grassi, M., W. Grate, J., Gromov, M., Guan, M., Guardincerri, Y., Gulinatti, A., K. Haaland, R., Hackett, B., Harrop, B., Herner, K., W. Hoppe, E., Horikawa, S., Hungerford, E., Ianni, Al., Ianni, An., Ivashchuk, O., James, I., N. Johnson, T., Jollet, C., Keeter, K., Kendziora, C., Kobychev, V., Koh, G., Korablev, D., Korga, G., Kubankin, A., W. Kuss, M., Lissia, M., Li, X., U. Lodi, G., Lombardi, P., Longo, G., Loverre, P., Luitz, S., Lussana, R., Luzzi, L., Ma, Y., A. Machado, A., Machulin, I., Mais, L., Mandarano, A., Mapelli, L., Marcante, M., Mari, S., Mariani, M., Maricic, J., Marinelli, M., Marini, L., J. Martoff, C., Mascia, M., Meregaglia, A., D. Meyers, P., Miletic, T., Milincic, R., Miller, J.D., Moioli, S., Monasterio, S., Montanari, D., Monte, A., Montuschi, M., E. Monzani, M., Morrocchi, M., Mosteiro, P., Mount, B., Mu, W., N. Muratova, V., Murphy, S., Musico, P., Napolitano, J., Nelson, A., Nosov, V., N. Nurakhov, N., Odrowski, S., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Palmas, S., Pantic, E., Paoloni, E., Parmeggiano, S., Paternoster, G., Pazzona, F., Pelczar, K., A. Pellegrini, L., Pelliccia, N., Perasso, S., Peronio, P., Perotti, F., Perruzza, R., Piemonte, C., Pilo, F., Pocar, A., Pordes, S., Pugachev, D., Qian, H., Radics, B., Randle, K., Ranucci, G., Razeti, M., Razeto, A., Rech, I., Regazzoni, V., Regenfus, C., Reinhold, B., Renshaw, A., Rescigno, M., Ricotti, M., Riffard, Q., Rizzardini, S., Romani, A., Romero, L., Rossi, B., Rossi, N., Rountree, D., Rubbia, A., Ruggeri, A., Sablone, D., Saggese, P., Salatino, P., Salemme, L., Sands, W., Sangiorgio, S., Sant, M., Santorelli, R., Sanzaro, M., Savarese, C., Sechi, E., Segreto, E., Semenov, D., Shchagin, A., Shekhtman, L., Shemyakina, E., Shields, E., Simeone, M., N. Singh, P., Skorokhvatov, M., Smallcomb, M., Smirnov, O., Sokolov, A., Sotnikov, A., Stanford, C., B. Suffritti, G., Suvorov, Y., Tamborini, D., Tartaglia, R., Tatarowicz, J., Testera, G., Tonazzo, A., Tosi, A., Trinchese, P., Unzhakov, E., Vacca, A., Verducci, M., Viant, T., Villa, F., Vishneva, A., Vogelaar, B., Wada, M., Walker, S., Wang, H., Wang, Y., Watson, A., Westerdale, S., Wilhelmi, J., Wojcik, M., Wu, S., Xiang, X., Xu, J., Yang, C., Yoo, J., Zappa, F., Zappalà, G., Zavatarelli, S., Zec, A., Zhong, W., Zhu, C., Zullo, A., Zullo, M., Zuzel, G., Bottino, B, Aalseth, C, Acconcia, G, Acerbi, F, Agnes, P, Agostino, L, Albuquerque, I, Alexander, T, Alton, A, Ampudia, P, Ardito, R, Arisaka, K, Arnquist, I, Asner, D, Back, H, Baldin, B, Batignani, G, Biery, K, Bisogni, M, Bocci, V, Bondar, A, Bonfini, G, Bonivento, W, Bossa, M, Brigatti, A, Brodsky, J, Budano, F, Bunker, R, Bussino, S, Buttafava, M, Buzulutskov, A, Cadeddu, M, Cadoni, M, Calandri, N, Calaprice, F, Calvo, J, Campajola, L, Canci, N, Candela, A, Cantini, C, Cao, H, Caravati, M, Cariello, M, Carlini, M, Carpinelli, M, Castellani, A, Catalanotti, S, Cavalcante, P, Chepurnov, A, Cicalò, C, Citterio, M, Cocco, A, Corgiolu, S, Covone, G, Crivelli, P, D'Angelo, D, D'Incecco, M, Daniel, M, Davini, S, De Cecco, S, De Deo, M, De Guido, G, De Vincenzi, M, Demontis, P, Derbin, A, Devoto, A, Di Eusanio, F, Di Pietro, G, Dionisi, C, Dolgov, A, Dromia, I, Dussoni, S, Edkins, E, Empl, A, Fan, A, Ferri, A, Filip, C, Fiorillo, G, Fomenko, K, Forster, G, Franco, D, Froudakis, G, Gabriele, F, Gabrieli, A, Galbiati, C, Gendotti, A, Ghioni, M, Ghisi, A, Giagu, S, Gibertoni, G, Giganti, C, Giorgi, M, Giovannetti, G, Gligan, M, Gola, A, Goretti, A, Granato, F, Grassi, M, Grate, J, Gromov, M, Guan, M, Guardincerri, Y, Gulinatti, A, Haaland, R, Hackett, B, Harrop, B, Herner, K, Hoppe, E, Horikawa, S, Hungerford, E, Ianni, A, Ivashchuk, O, James, I, Johnson, T, Jollet, C, Keeter, K, Kendziora, C, Kobychev, V, Koh, G, Korablev, D, Korga, G, Kubankin, A, Kuss, M, Lissia, M, Li, X, Lodi, G, Lombardi, P, Longo, G, Loverre, P, Luitz, S, Lussana, R, Luzzi, L, Ma, Y, Machado, A, Machulin, I, Mais, L, Mandarano, A, Mapelli, L, Marcante, M, Mari, S, Mariani, M, Maricic, J, Marinelli, M, Marini, L, Martoff, C, Mascia, M, Meregaglia, A, Meyers, P, Miletic, T, Milincic, R, Miller, J, Moioli, S, Monasterio, S, Montanari, D, Monte, A, Montuschi, M, Monzani, M, Morrocchi, M, Mosteiro, P, Mount, B, Mu, W, Muratova, V, Murphy, S, Musico, P, Napolitano, J, Nelson, A, Nosov, V, Nurakhov, N, Odrowski, S, Oleinik, A, Orsini, M, Ortica, F, Pagani, L, Pallavicini, M, Palmas, S, Pantic, E, Paoloni, E, Parmeggiano, S, Paternoster, G, Pazzona, F, Pelczar, K, Pellegrini, L, Pelliccia, N, Perasso, S, Peronio, P, Perotti, F, Perruzza, R, Piemonte, C, Pilo, F, Pocar, A, Pordes, S, Pugachev, D, Qian, H, Radics, B, Randle, K, Ranucci, G, Razeti, M, Razeto, A, Rech, I, Regazzoni, V, Regenfus, C, Reinhold, B, Renshaw, A, Rescigno, M, Ricotti, M, Riffard, Q, Rizzardini, S, Romani, A, Romero, L, Rossi, B, Rossi, N, Rountree, D, Rubbia, A, Ruggeri, A, Sablone, D, Saggese, P, Salatino, P, Salemme, L, Sands, W, Sangiorgio, S, Sant, M, Santorelli, R, Sanzaro, M, Savarese, C, Sechi, E, Segreto, E, Semenov, D, Shchagin, A, Shekhtman, L, Shemyakina, E, Shields, E, Simeone, M, Singh, P, Skorokhvatov, M, Smallcomb, M, Smirnov, O, Sokolov, A, Sotnikov, A, Stanford, C, Suffritti, G, Suvorov, Y, Tamborini, D, Tartaglia, R, Tatarowicz, J, Testera, G, Tonazzo, A, Tosi, A, Trinchese, P, Unzhakov, E, Vacca, A, Verducci, M, Viant, T, Villa, F, Vishneva, A, Vogelaar, B, Wada, M, Walker, S, Wang, H, Wang, Y, Watson, A, Westerdale, S, Wilhelmi, J, Wojcik, M, Wu, S, Xiang, X, Xu, J, Yang, C, Yoo, J, Zappa, F, Zappalà, G, Zavatarelli, S, Zec, A, Zhong, W, Zhu, C, Zullo, A, Zullo, M, Zuzel, G, Bottino, B., Aalseth, C. E., Acconcia, G., Acerbi, F., Agnes, P., Agostino, L., Albuquerque, I. F. M., Alexander, T., Alton, A., Ampudia, P., Ardito, R., Arisaka, K., Arnquist, I. J., Asner, D. M., Back, H. O., Baldin, B., Batignani, G., Biery, K., Bisogni, M. G., Bocci, V., Bondar, A., Bonfini, G., Bonivento, W., Bossa, M., Brigatti, A., Brodsky, J., Budano, F., Bunker, R., Bussino, S., Buttafava, M., Buzulutskov, A., Cadeddu, M., Cadoni, M., Calandri, N., Calaprice, F., Calvo, J., Campajola, Luigi, Canci, N., Candela, A., Cantini, C., Cao, H., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Castellani, A., Catalanotti, Sergio, Cavalcante, P., Chepurnov, A., Cicalo, C., Citterio, M., Cocco, ALFREDO GIUSEPPE, Corgiolu, S., Covone, Giovanni, Crivelli, P., D'Angelo, D., D'Incecco, M., Daniel, M., Davini, S., De Cecco, S., De Deo, M., De Guido, G., De Vincenzi, M., Demontis, P., Derbin, A., Devoto, A., Di Eusanio, F., Di Pietro, G., Dionisi, C., Dolgov, A., Dromia, I., Dussoni, S., Edkins, E., Empl, A., Fan, A., Ferri, A., Filip, C. O., Fiorillo, Giuliana, Fomenko, K., Forster, G., Franco, D., Froudakis, G. E., Gabriele, F., Gabrieli, A., Galbiati, C., Gendotti, A., Ghioni, M., Ghisi, A., Giagu, S., Gibertoni, G., Giganti, C., Giorgi, M., Giovannetti, G. K., Gligan, M. L., Gola, A., Goretti, A., Granato, F., Grassi, M., Grate, J. W., Gromov, M., Guan, M., Guardincerri, Y., Gulinatti, A., Haaland, R. K., Hackett, B., Harrop, B., Herner, K., Hoppe, E. W., Horikawa, S., Hungerford, E., Ianni, A. l., Ianni, A. n., Ivashchuk, O., James, I., Johnson, T. N., Jollet, C., Keeter, K., Kendziora, C., Kobychev, V., Koh, G., Korablev, D., Korga, G., Kubankin, A., Kuss, M. W., Lissia, M., Li, X., Lodi, G. U., Lombardi, P., Longo, Giuseppe, Loverre, P., Luitz, S., Lussana, R., Luzzi, L., Ma, Y., Machado, A. A., Machulin, I., Mais, L., Mandarano, A., Mapelli, L., Marcante, M., Mari, S., Mariani, M., Maricic, J., Marinelli, M., Marini, L., Martoff, C. J., Mascia, M., Meregaglia, A., Meyers, P. D., Miletic, T., Milincic, R., Miller, J. D., Moioli, S., Monasterio, S., Montanari, D., Monte, A., Montuschi, M., Monzani, M. E., Morrocchi, M., Mosteiro, P., Mount, B., Mu, W., Muratova, V. N., Murphy, S., Musico, P., Napolitano, J., Nelson, A., Nosov, V., Nurakhov, N. N., Odrowski, S., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Palmas, S., Pantic, E., Paoloni, E., Parmeggiano, S., Paternoster, G., Pazzona, F., Pelczar, K., Pellegrini, L. A., Pelliccia, N., Perasso, S., Peronio, P., Perotti, F., Perruzza, R., Piemonte, C., Pilo, F., Pocar, A., Pordes, S., Pugachev, D., Qian, H., Radics, B., Randle, K., Ranucci, G., Razeti, M., Razeto, A., Rech, I., Regazzoni, V., Regenfus, C., Reinhold, B., Renshaw, A., Rescigno, M., Ricotti, M., Riffard, Q., Rizzardini, S., Romani, A., Romero, L., Rossi, B., Rossi, N., Rountree, D., Rubbia, A., Ruggeri, A., Sablone, D., Saggese, P., Salatino, Piero, Salemme, Lucia, Sands, W., Sangiorgio, S., Sant, M., Santorelli, R., Sanzaro, M., Savarese, C., Sechi, E., Segreto, E., Semenov, D., Shchagin, A., Shekhtman, L., Shemyakina, E., Shields, E., Simeone, Marino, Singh, P. N., Skorokhvatov, M., Smallcomb, M., Smirnov, O., Sokolov, A., Sotnikov, A., Stanford, C., Suffritti, G. B., Suvorov, Y., Tamborini, D., Tartaglia, R., Tatarowicz, J., Testera, G., Tonazzo, A., Tosi, A., Trinchese, P., Unzhakov, E., Vacca, A., Verducci, M., Viant, T., Villa, F., Vishneva, A., Vogelaar, B., Wada, M., Walker, Susan Elizabeth, Wang, H., Wang, Y., Watson, A., Westerdale, S., Wilhelmi, J., Wojcik, M., Wu, S., Xiang, X., Xu, J., Yang, C., Yoo, J., Zappa, F., Zappala, G., Zavatarelli, S., Zec, A., Zhong, W., Zhu, C., Zullo, A., Zullo, M., Zuzel, G., AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), DarkSide, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Budano, Federico, Bussino, Severino Angelo Maria, Campajola, L., Catalanotti, S., Cicalò, C., Cocco, A. G., Covone, G., DE VINCENZI, Mario, Fiorillo, G., James, Irina, Longo, G., Mari, Stefano Maria, Salatino, P., Salemme, L., Simeone, M., Walker, S., Zappalà, G., Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Physics and Astronomy (miscellaneous), Physics::Instrumentation and Detectors, background, scintillation counter: liquid, DarkSide, Astronomy and Astrophysics, WIMP: detector, dark matter: direct detection, Astronomy and Astrophysic, time projection chamber: liquid argon, dark matter, Laboratori Nazionali del Gran Sasso (LNGS), deep underground detector, Gran Sasso, cryogenics, radioactivity, atmosphere, High Energy Physics::Experiment, Cherenkov, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Nuclear Experiment, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], experimental results
Abstract: International audience; DarkSide is a dark matter direct search experiment at Laboratori Nazionali del Gran Sasso (LNGS). DarkSide is based on the detection of rare nuclear recoils possibly induced by hypothetical dark matter particles, which are supposed to be neutral, massive (m > 10 GeV) and weakly interactive (WIMP). The dark matter detector is a two-phase time projection chamber (TPC) filled with ultra-pure liquid argon. The TPC is placed inside a muon and a neutron active vetoes to suppress the background. Using argon as active target has many advantages, the key features are the strong discriminant power between nuclear and electron recoils, the spatial reconstruction and easy scalability to multi-tons size. At the moment DarkSide-50 is filled with ultra-pure argon, extracted from underground sources, and from April 2015 it is taking data in its final configuration. When combined with the preceding search with an atmospheric argon target, it is possible to set a 90% CL upper limit on the WIMP-nucleon spin-independent cross section of 2.0×10−44 cm2 for a WIMP mass of 100 GeV/c2. The next phase of the experiment, DarkSide-20k, will be the construction of a new detector with an active mass of ∼ 20 tons.
Published: 2017
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49. Design and construction of a new detector to measure ultra-low radioactive-isotope contamination of argon

Author: Aalseth, C.E., primary, Abdelhakim, S., additional, Acerbi, F., additional, Agnes, P., additional, Ajaj, R., additional, Albuquerque, I.F.M., additional, Alexander, T., additional, Alici, A., additional, Alton, A.K., additional, Amaudruz, P., additional, Ameli, F., additional, Anstey, J., additional, Antonioli, P., additional, Arba, M., additional, Arcelli, S., additional, Ardito, R., additional, Arnquist, I.J., additional, Arpaia, P., additional, Asner, D.M., additional, Asunskis, A., additional, Ave, M., additional, Back, H.O., additional, Barbaryan, V., additional, Olmedo, A. Barrado, additional, Batignani, G., additional, Bisogni, M.G., additional, Bocci, V., additional, Bondar, A., additional, Bonfini, G., additional, Bonivento, W., additional, Borisova, E., additional, Bottino, B., additional, Boulay, M.G., additional, Bunker, R., additional, Bussino, S., additional, Buzulutskov, A., additional, Cadeddu, M., additional, Cadoni, M., additional, Caminata, A., additional, Canci, N., additional, Candela, A., additional, Cantini, C., additional, Caravati, M., additional, Cariello, M., additional, Carnesecchi, F., additional, Carpinelli, M., additional, Castellani, A., additional, Castello, P., additional, Catalanotti, S., additional, Cataudella, V., additional, Cavalcante, P., additional, Cavazza, D., additional, Cavuoti, S., additional, Cebrian, S., additional, Ruiz, J.M. Cela, additional, Celano, B., additional, Cereseto, R., additional, Cheng, W., additional, Chepurnov, A., additional, Cicalò, C., additional, Cifarelli, L., additional, Citterio, M., additional, Coccetti, F., additional, Cocco, A.G., additional, Cocco, V., additional, Colocci, M., additional, Consiglio, L., additional, Cossio, F., additional, Covone, G., additional, Crivelli, P., additional, D'Antone, I., additional, D'Incecco, M., additional, D'Urso, D., additional, Rolo, M.D. Da Rocha, additional, Dadoun, O., additional, Daniel, M., additional, Davini, S., additional, Candia, A. De, additional, Cecco, S. De, additional, Deo, M. De, additional, Falco, A. De, additional, Filippis, G. De, additional, Gruttola, D. De, additional, Guido, G. De, additional, Rosa, G. De, additional, Dellacasa, G., additional, Demontis, P., additional, DePaquale, S., additional, Derbin, A.V., additional, Devoto, A., additional, Eusanio, F. Di, additional, Noto, L. Di, additional, Pietro, G. Di, additional, Stefano, P. Di, additional, Dionisi, C., additional, Dolganov, G., additional, Dordei, F., additional, Downing, M., additional, Edalatfar, F., additional, Empl, A., additional, Diaz, M. Fernandez, additional, Ferri, A., additional, Filip, C., additional, Fiorillo, G., additional, Fomenko, K., additional, Franceschi, A., additional, Franco, D., additional, Froudakis, G.E., additional, Gabriele, F., additional, Gabrieli, A., additional, Galbiati, C., additional, Garbini, M., additional, Abia, P. Garcia, additional, Fora, D. Gascón, additional, Gendotti, A., additional, Ghiano, C., additional, Ghisi, A., additional, Giagu, S., additional, Giampa, P., additional, Giampaolo, R.A., additional, Giganti, C., additional, Giorgi, M.A., additional, Giovanetti, G.K., additional, Gligan, M.L., additional, Gola, A., additional, Gorchakov, O., additional, Grab, M., additional, Diaz, R. Graciani, additional, Granato, F., additional, Grassi, M., additional, Grate, J.W., additional, Grigoriev, G.Y., additional, Grobov, A., additional, Gromov, M., additional, Guan, M., additional, Guerra, M.B.B., additional, Guerzoni, M., additional, Gulino, M., additional, Haaland, R.K., additional, Hackett, B.R., additional, Hallin, A., additional, Harrop, B., additional, Hoppe, E.W., additional, Horikawa, S., additional, Hosseini, B., additional, Hubaut, F., additional, Humble, P., additional, Hungerford, E.V., additional, Ianni, An., additional, Ilyasov, A., additional, Ippolito, V., additional, Jillings, C., additional, Keeter, K., additional, Kendziora, C.L., additional, Kim, S., additional, Kochanek, I., additional, Kondo, K., additional, Kopp, G., additional, Korablev, D., additional, Korga, G., additional, Kubankin, A., additional, Kugathasan, R., additional, Kuss, M., additional, Kuźniak, M., additional, Commara, M. La, additional, Delfa, L. La, additional, Lai, M., additional, Langrock, S., additional, Lebois, M., additional, Lehnert, B., additional, Levashko, N., additional, Li, X., additional, Liqiang, Q., additional, Lissia, M., additional, Lodi, G.U., additional, Longo, G., additional, Manzano, R. López, additional, Lussana, R., additional, Luzzi, L., additional, Machado, A.A., additional, Machulin, I.N., additional, Mandarano, A., additional, Mapelli, L., additional, Marcante, M., additional, Margotti, A., additional, Mari, S.M., additional, Mariani, M., additional, Maricic, J., additional, Marinelli, M., additional, Marras, D., additional, Martínez, M., additional, Morales, J.J. Martínez, additional, Rojas, A.D. Martinez, additional, Martoff, C.J., additional, Mascia, M., additional, Mason, J., additional, Masoni, A., additional, Mazzi, A., additional, McDonald, A.B., additional, Messina, A., additional, Meyers, P.D., additional, Miletic, T., additional, Milincic, R., additional, Moggi, A., additional, Moioli, S., additional, Monroe, J., additional, Morrocchi, M., additional, Mroz, T., additional, Mu, W., additional, Muratova, V.N., additional, Murphy, S., additional, Muscas, C., additional, Musico, P., additional, Nania, R., additional, Napolitano, T., additional, Agasson, A. Navrer, additional, Nessi, M., additional, Nikulin, I., additional, Oleinik, A., additional, Oleynikov, V., additional, Orsini, M., additional, Ortica, F., additional, Pagani, L., additional, Pallavicini, M., additional, Palmas, S., additional, Pandola, L., additional, Pantic, E., additional, Paoloni, E., additional, Paternoster, G., additional, Pazzona, F., additional, Peeters, S., additional, Pegoraro, P.A., additional, Pelczar, K., additional, Pellegrini, L.A., additional, Pellegrino, C., additional, Pelliccia, N., additional, Perotti, F., additional, Pesudo, V., additional, Picciau, E., additional, Piemonte, C., additional, Pietropaolo, F., additional, Pocar, A., additional, Pollmann, T.R., additional, Portaluppi, D., additional, Poudel, S.S., additional, Pralavorio, P., additional, Price, D., additional, Radics, B., additional, Raffaelli, F., additional, Ragusa, F., additional, Razeti, M., additional, Razeto, A., additional, Regazzoni, V., additional, Regenfus, C., additional, Renshaw, A.L., additional, Rescia, S., additional, Rescigno, M., additional, Retiere, F., additional, Rignanese, L.P., additional, Rivetti, A., additional, Romani, A., additional, Romero, L., additional, Rossi, N., additional, Rubbia, A., additional, Sablone, D., additional, Sala, P., additional, Salatino, P., additional, Samoylov, O., additional, García, E. Sánchez, additional, Sanfilippo, S., additional, Sant, M., additional, Santone, D., additional, Santorelli, R., additional, Savarese, C., additional, Scapparone, E., additional, Schlitzer, B., additional, Scioli, G., additional, Segreto, E., additional, Seifert, A., additional, Semenov, D.A., additional, Shchagin, A., additional, Sheshukov, A., additional, Siddhanta, S., additional, Simeone, M., additional, Singh, P.N., additional, Skensved, P., additional, Skorokhvatov, M.D., additional, Smirnov, O., additional, Sobrero, G., additional, Sokolov, A., additional, Sotnikov, A., additional, Stainforth, R., additional, Steri, A., additional, Stracka, S., additional, Strickland, V., additional, Suffritti, G.B., additional, Sulis, S., additional, Suvorov, Y., additional, Szelc, A.M., additional, Tartaglia, R., additional, Testera, G., additional, Thorpe, T., additional, Tonazzo, A., additional, Tosi, A., additional, Tuveri, M., additional, Unzhakov, E.V., additional, Usai, G., additional, Vacca, A., additional, Vázquez-Jáuregui, E., additional, Verducci, M., additional, Viant, T., additional, Viel, S., additional, Villa, F., additional, Vishneva, A., additional, Vogelaar, R.B., additional, Wada, M., additional, Wahl, J., additional, Walding, J.J., additional, Wang, H., additional, Wang, Y., additional, Westerdale, S., additional, Wheadon, R.J., additional, Williams, R., additional, Wilson, J., additional, Wojcik, Marcin, additional, Wojcik, Mariusz, additional, Wu, S., additional, Xiao, X., additional, Yang, C., additional, Ye, Z., additional, Zuffa, M., additional, and Zuzel, G., additional
Published: 2020
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50. Exploring variability in %predicted DLCO during pre-operative assessment for lung cancer resection across a cancer alliance

Author: Argus, L., primary, Evison, M., additional, and Granato, F., additional
Published: 2020
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