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12 results on '"Granados-Rodríguez, Melissa"'

1. Breaking the Mucin Barrier: A New Affinity Chromatography-Mass Spectrometry Approach to Unveil Potential Cell Markers and Pathways Altered in Pseudomyxoma Peritonei

Author

Romero-Ruiz, Antonio, Granados-Rodríguez, Melissa, Bura, Florina I., Valenzuela-Molina, Francisca, Rufián-Andújar, Blanca, Martínez-López, Ana, Rodríguez-Ortiz, Lidia, Ortega-Salas, Rosa, Torres-Martínez, María, Moreno-Serrano, Ana, Castaño, Justo, Michán, Carmen, Alhama, José, Vázquez-Borrego, Mari C., and Arjona-Sánchez, Álvaro

Published
2024
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2. Antitumor effect of a small-molecule inhibitor of KRASG12D in xenograft models of mucinous appendicular neoplasms

Author

Vázquez-Borrego, Mari C., Granados-Rodríguez, Melissa, Bura, Florina I., Martínez-López, Ana, Rufián-Andújar, Blanca, Valenzuela-Molina, Francisca, Rodríguez-Ortiz, Lidia, Haro-Yuste, Sergio, Moreno-Serrano, Ana, Ortega-Salas, Rosa, Pineda-Reyes, Rafael, Michán, Carmen, Alhama, José, Romero-Ruiz, Antonio, and Arjona-Sánchez, Álvaro

Published
2023
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3. A Proposal for Modification of the PSOGI Classification According to the Ki-67 Proliferation Index in Pseudomyxoma Peritonei

Author

Arjona-Sánchez, Álvaro, Martínez-López, Ana, Valenzuela-Molina, Francisca, Rufián-Andújar, Blanca, Rufián-Peña, Sebastián, Casado-Adam, Ángela, Sánchez-Hidalgo, Juan Manuel, Rodríguez-Ortiz, Lidia, Medina-Fernández, Francisco Javier, Díaz-López, Cesar, Granados-Rodríguez, Melissa, Ortega-Salas, Rosa, Castaño, Justo P., Tena-Sempere, Manuel, Briceño-Delgado, Javier, and Romero-Ruíz, Antonio

Published
2022
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4. Kisspeptin signaling in astrocytes modulates the reproductive axis

Author

Torres, Encarnacion, primary, Pellegrino, Giuliana, additional, Granados-Rodríguez, Melissa, additional, Fuentes-Fayos, Antonio C., additional, Velasco, Inmaculada, additional, Coutteau-Robles, Adrian, additional, Legrand, Amandine, additional, Shanabrough, Marya, additional, Perdices-Lopez, Cecilia, additional, Leon, Silvia, additional, Yeo, Shel H., additional, Manchishi, Stephen M., additional, Sánchez-Tapia, Maria J., additional, Navarro, Victor M., additional, Pineda, Rafael, additional, Roa, Juan, additional, Naftolin, Frederick, additional, Argente, Jesús, additional, Luque, Raúl M., additional, Chowen, Julie A., additional, Horvath, Tamas L., additional, Prevot, Vicent, additional, Sharif, Ariane, additional, Colledge, William H., additional, Tena-Sempere, Manuel, additional, and Romero-Ruiz, Antonio, additional

Published
2024
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5. Intra-tumoural bromelain and N-acetylcysteine for recurrent and unresectable pseudomyxoma peritonei: phase I/II trial

Author

Rodríguez-Ortiz, Lidia, primary, Vázquez-Borrego, Mari C, additional, Bura, Florina I, additional, Granados-Rodríguez, Melissa, additional, Valenzuela-Molina, Francisca, additional, Rufián-Andújar, Blanca, additional, Martínez-López, Ana, additional, Ortega-Salas, Rosa, additional, Espejo-Herrero, Juan José, additional, Romero-Ruiz, Antonio, additional, and Arjona-Sánchez, Álvaro, additional

Published
2024
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6. Breaking the mucin barrier: a new affinity chromatography-mass spectrometry approach to unveil potential cell markers and pathways altered in Pseudomyxoma peritonei

Author

Romero-Ruiz, Antonio, primary, Granados-Rodríguez, Melissa, additional, Bura, Florina I., additional, Valenzuela-Molina, Francisca, additional, Rufián-Andújar, Blanca, additional, Martínez-López, Ana, additional, Rodríguez-Ortiz, Lidia, additional, Ortega-Salas, Rosa, additional, Torres-Martínez, María, additional, Moreno-Serrano, Ana, additional, Castaño, Justo, additional, Michán, Carmen, additional, Alhama, José, additional, Vázquez-Borrego, Mari C., additional, and Arjona-Sánchez, Álvaro, additional

Published
2024
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8. ASO Visual Abstract: A Proposal for Modification of PSOGI Classification According to Ki-67 Proliferation Index in Pseudomyxoma peritonei

Author

Arjona-Sánchez, Álvaro, Martínez-López, Ana, Valenzuela-Molina, Francisca, Rufián-Andújar, Blanca, Rufián-Peña, Sebastián, Casado-Adam, Ángela, Sánchez-Hidalgo, Juan Manuel, Rodríguez-Ortiz, Lidia, Medina-Fernández, Francisco Javier, Díaz-López, Cesar, Granados-Rodríguez, Melissa, Ortega-Salas, Rosa, Castaño, Justo P., Tena-Sempere, Manuel, Briceño-Delgado, Javier, and Romero-Ruíz, Antonio

Published
2021
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9. Intraoperative oxygen tension and redox homeostasis in Pseudomyxoma peritonei: A short case series

Author

Valenzuela-Molina, Francisca, primary, Bura, Florina I., additional, Vázquez-Borrego, Mari C., additional, Granados-Rodríguez, Melissa, additional, Rufián-Andujar, Blanca, additional, Rufián-Peña, Sebastián, additional, Casado-Adam, Ángela, additional, Sánchez-Hidalgo, Juan Manuel, additional, Rodríguez-Ortiz, Lidia, additional, Ortega-Salas, Rosa, additional, Martínez-López, Ana, additional, Michán, Carmen, additional, Alhama, José, additional, Arjona-Sánchez, Álvaro, additional, and Romero-Ruiz, Antonio, additional

Published
2023
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10. Antitumor effect of a small-molecule inhibitor of KRASG12D in xenograft models of mucinous appendicular neoplasms.

Author

Vázquez-Borrego, Mari C., Granados-Rodríguez, Melissa, Bura, Florina I., Martínez-López, Ana, Rufián-Andújar, Blanca, Valenzuela-Molina, Francisca, Rodríguez-Ortiz, Lidia, Haro-Yuste, Sergio, Moreno-Serrano, Ana, Ortega-Salas, Rosa, Pineda-Reyes, Rafael, Michán, Carmen, Alhama, José, Romero-Ruiz, Antonio, and Arjona-Sánchez, Álvaro

Subjects
ONCOGENIC proteins, PULMONARY alveolar proteinosis, TUMOR growth, PERITONEUM, DISEASE relapse, TUMORS
Abstract

Pseudomyxoma peritonei (PMP) is a rare disease characterized by a massive accumulation of mucus in the peritoneal cavity. The only effective treatment is aggressive surgery, aimed at removing all visible tumors. However, a high percentage of patients relapse, with subsequent progression and death. Recently, there has been an increase in therapies that target mutated oncogenic proteins. In this sense, KRAS has been reported to be highly mutated in PMP, with KRASG12D being the most common subtype. Here, we tested the efficacy of a small-molecule KRASG12D inhibitor, MRTX1133, in a high-grade PMP xenograft mouse model carrying a KRASG12D mutation. The results obtained in this work showed a profound inhibition of tumor growth, which was associated with a reduction in cell proliferation, an increase in apoptosis, and a reduction in the MAPK and PI3K/AKT/mTOR signaling pathways. In conclusion, these results demonstrate the high potency and efficacy of MRTX1133 in KRASG12D-PMP tumors and provide a rationale for clinical trials. [ABSTRACT FROM AUTHOR]

Published
2023
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11. A New Molecular (P)Layer in Pseudomyxoma Peritonei: The Splicing Machinery is Dysregulated and Linked to Low Survival

Author

Moreno-Montilla, María Trinidad, primary, Alors-Pérez, Emilia, additional, Martínez-López, Ana, additional, Blázquez-Encinas, Ricardo, additional, García-Vioque, Víctor, additional, Rodríguez-Ortiz, Lidia, additional, Valenzuela-Molina, Francisca, additional, Rufián-Andújar, Blanca, additional, Granados-Rodríguez, Melissa, additional, Ortega-Salas, Rosa, additional, Vázquez-Borrego, Mari C., additional, Romero-Ruiz, Antonio, additional, Castaño, Justo P., additional, Arjona-Sánchez, Álvaro, additional, and Ibáñez-Costa, Alejandro, additional

Published
2022
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