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1. Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression

Author

Molina, Oscar, Ortega-Sabater, Carmen, Thampi, Namitha, Fernández-Fuentes, Narcís, Guerrero-Murillo, Mercedes, Martínez-Moreno, Alba, Vinyoles, Meritxell, Velasco-Hernández, Talía, Bueno, Clara, Trincado, Juan L, Granada, Isabel, Campos, Diana, Giménez, Carles, Boer, Judith M, den Boer, Monique L, Calvo, Gabriel F, Camós, Mireia, Fuster, Jose-Luis, Velasco, Pablo, Ballerini, Paola, Locatelli, Franco, Mullighan, Charles G, Spierings, Diana C J, Foijer, Floris, Pérez-García, Víctor M, and Menéndez, Pablo

Published
2024
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3. Identification of novel NUP98 fusion partners and co-mutations in Acute Myeloid Leukemia: an adult cohort study

Author

Heald, James S, primary, Méndez López, Aleix, additional, Pato, Miguel L, additional, Ruiz-Xiville, Neus, additional, Cabezón, Marta, additional, Zamora, Lurdes, additional, Vives, Susana, additional, Coll Jorda, Rosa, additional, Maluquer Artigal, Clara, additional, Granada, Isabel, additional, Sole, Francesc, additional, Esteller, Manel, additional, and Berdasco, María, additional

Published
2024
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4. Adverse prognostic impact of complex karyotype (≥3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL)

Author

Genescà, Eulàlia, Morgades, Mireia, González-Gil, Celia, Fuster-Tormo, Francisco, Haferlach, Claudia, Meggendorfer, Manja, Montesinos, Pau, Barba, Pere, Gil, Cristina, Coll, Rosa, Moreno, María-José, Martínez-Carballeira, Daniel, García-Cadenas, Irene, Vives, Susana, Ribera, Jordi, González-Campos, José, Díaz-Beya, Marina, Mercadal, Santiago, Artola, María-Teresa, Cladera, Antonia, Tormo, Mar, Bermúdez, Arancha, Vall-llovera, Ferran, Martínez-Sánchez, Pilar, Amigo, María-Luz, Monsalvo, Silvia, Novo, Andrés, Cervera, Marta, García-Guiñon, Antonio, Ciudad, Juana, Cervera, José, Hernández-Rivas, Jesús-María, Granada, Isabel, Haferlach, Torsten, Orfao, Alberto, Solé, Francesc, and Ribera, Josep-Maria

Published
2021
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12. CD200 genotype is associated with clinical outcome of patients with multiple myeloma

Author

Gonzalez-Montes, Yolanda, primary, Osca-Gelis, Gemma, additional, Rodriguez-Romanos, Rocío, additional, Villavicencio, Alicia, additional, González-Bártulos, Marta, additional, Llopis, Francesca, additional, Clapes, Victòria, additional, Oriol, Albert, additional, Sureda, Anna, additional, Escoda, Lourdes, additional, Sarrà, Josep, additional, Garzó, Ana, additional, Lloveras, Natàlia, additional, Gómez, Beatriz, additional, Granada, Isabel, additional, and Gallardo, David, additional

Published
2024
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13. Persistence of Chronic Lymphocytic Leukemia Stem-like Populations under Simultaneous In Vitro Treatment with Curcumin, Fludarabine, and Ibrutinib: Implications for Therapy Resistance

Author

Bistué-Rovira, Àngel, primary, Rico, Laura G., additional, Bardina, Jorge, additional, Juncà, Jordi, additional, Granada, Isabel, additional, Bradford, Jolene A., additional, Ward, Michael D., additional, Salvia, Roser, additional, Solé, Francesc, additional, and Petriz, Jordi, additional

Published
2024
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14. Optical genome mapping: technical basis and applications in hematological malignancies

Author

Puiggros, Anna, primary, Mallo, Mar, additional, Díaz-González, Álvaro, additional, Avetisyan, Gayane, additional, Cisneros, Adela, additional, Collado, Rosa, additional, García-Hoyos, María, additional, García-Serra, Rocío, additional, García-Ruiz, Cristian, additional, Genescà, Eulàlia, additional, Gómez-García, Ana, additional, González, Celia, additional, Ibáñez, Mariam, additional, Kamaso, Joanna, additional, Ramírez-Orellana, Manuel, additional, Rodríguez-Rivera, María, additional, Salido, Marta, additional, Such, Esperanza, additional, Solé, Francesc, additional, Álvarez-De Andrés, Sara, additional, Granada, Isabel, additional, and Espinet, Blanca, additional

Published
2023
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15. Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression

Author

Molina, Oscar, primary, Ortega-Sabater, Carmen, additional, Thampi, Namitha, additional, Fernández-Fuentes, Narcís, additional, Guerrero-Murillo, Mercedes, additional, Martínez-Moreno, Alba, additional, Vinyoles, Meritxell, additional, Velasco-Hernández, Talía, additional, Bueno, Clara, additional, Trincado, Juan L, additional, Granada, Isabel, additional, Campos, Diana, additional, Giménez, Carles, additional, Boer, Judith M, additional, den Boer, Monique L, additional, Calvo, Gabriel F, additional, Camós, Mireia, additional, Fuster, Jose-Luis, additional, Velasco, Pablo, additional, Ballerini, Paola, additional, Locatelli, Franco, additional, Mullighan, Charles G, additional, Spierings, Diana C J, additional, Foijer, Floris, additional, Pérez-García, Víctor M, additional, and Menéndez, Pablo, additional

Published
2023
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19. Mutually-Exclusive Pathways between IKZF1 plus and RAS Mutations and TP53 double-Hit Alterations Lead Relapse in B-Other, Ph-like and Hyperdiploidy Genetic Groups in Adult B-Cell Acute Lymphoblastic Leukemia

Author

Navas Acosta, Josgrey Del Valle Del Valle, primary, González, Teresa, additional, Serramito-Gómez, Inmaculada, additional, Villaverde Ramiro, Angela, additional, Miguel-García, Cristina, additional, Santos-Mínguez, Sandra, additional, Ribera, Jordi, additional, Granada, Isabel, additional, Morgades, Mireia, additional, Sanchez, Ricardo, additional, Such, Esperanza, additional, Barrera, Susana, additional, Ciudad, Juana, additional, Orfao, Alberto, additional, Valls, Julio Davila, additional, De Las Heras, Natalia, additional, Fuster, José, additional, Garcia de Coca, Alfonso, additional, Labrador, Jorge, additional, Queizan Hernandez, Jose Antonio, additional, Mendoza, María Carmen, additional, Riesco, Susana, additional, Martín, Sandra, additional, Ribera, Josep-Maria, additional, Benito Sanchez, Maria Rocio, additional, and Hernández-Rivas, Jesús María, additional

Published
2023
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20. ALL-268 Genetic Classification of B-Cell Precursor Adult Acute Lymphoblastic Leukemia Patients Enrolled in LAL19 Trial from the Pethema Group: Response to Treatment and Survival

Author

Ribera, Jordi, Granada, Isabel, González, Teresa, Morgades, Mireia, Sánchez, Ricardo, Such, Esperanza, Barrena, Susana, Ciudad, Juana, Soriano, Beatriz, Benito, Rocío, Avetisyan, Gayane, Lumbreras, Eva, Miguel, Cristina, Santos, Sandra, Zamora, Lurdes, Mallo, Mar, Genescà, Eulàlia, González, Celia, Lopes, Thaysa, Hernández-Rivas, Jesús-María, Orfao, Alberto, and Ribera, Josep Maria

Published
2022
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23. Clinical and biological significance of isolated Y chromosome loss in myelodysplastic syndromes and chronic myelomonocytic leukemia. A report from the Spanish MDS Group

Author

Nomdedeu, Meritxell, Pereira, Arturo, Calvo, Xavier, Colomer, Joan, Sole, Francesc, Arias, Amparo, Gomez, Candida, Luño, Elisa, Cervera, Jose, Arnan, Montserrat, Pomares, Helena, Ramos, Fernando, Oiartzabal, Itziar, Espinet, Blanca, Pedro, Carme, Arrizabalaga, Beatriz, Blanco, María Laura, Tormo, Mar, Hernandez-Rivas, Jesus Maria, Díez-Campelo, María, Ortega, Margarita, Valcárcel, David, Cedena, Maria-Teresa, Collado, Rosa, Grau, Javier, Granada, Isabel, Sanz, Guillermo, Campo, Elias, Esteve, Jordi, and Costa, Dolors

Published
2017
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24. BCL3 rearrangements in B-cell lymphoid neoplasms occur in two breakpoint clusters associated with different diseases

Author

Carbo-Meix, Anna, primary, Guijarro, Francesca, additional, Wang, Luojun, additional, Grau, Marta, additional, Royo, Romina, additional, Frigola, Gerard, additional, Playa-Albinyana, Heribert, additional, Buhler, Marco M., additional, Clot, Guillem, additional, Duran-Ferrer, Marti, additional, Lu, Junyan, additional, Granada, Isabel, additional, Baptista, Maria-Joao, additional, Navarro, Jose-Tomas, additional, Espinet, Blanca, additional, Puiggros, Anna, additional, Tapia, Gustavo, additional, Bandiera, Laura, additional, De Canal, Gabriella, additional, Bonoldi, Emanuela, additional, Climent, Fina, additional, Ribera-Cortada, Inmaculada, additional, Fernandez-Caballero, Mariana, additional, De la Banda, Esmeralda, additional, Do Nascimento, Janilson, additional, Pineda, Alberto, additional, Vela, Dolors, additional, Rozman, Maria, additional, Aymerich, Marta, additional, Syrykh, Charlotte, additional, Brousset, Pierre, additional, Perera, Miguel, additional, Yanez, Lucrecia, additional, Ortin, Jesus Xavier, additional, Tuset, Esperanza, additional, Zenz, Thorsten, additional, Cook, James R., additional, Swerdlow, Steven H., additional, Martin-Subero, Jose I., additional, Colomer, Dolors, additional, Matutes, Estella, additional, Bea, Silvia, additional, Costa, Dolors, additional, Nadeu, Ferran, additional, and Campo, Elias, additional

Published
2023
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25. P343: MUTATIONS IN GENES RELATED TO EPIGENETIC REGULATION, TREATMENT RESISTANCE AND IKZF1 PLUS PROFILE IDENTIFY RELAPSE PROFILES IN B-ALL.

Author

del Valle Navas Acosta, Josgrey, primary, Gonzalez, Teresa, additional, Serramito, Inmaculada, additional, Miguel, Cristina, additional, Santos, Sandra, additional, Villaverde, Angela, additional, Ribera, Jordi, additional, Granada, Isabel, additional, Morgades, Mireia, additional, Sánchez, Ricardo, additional, Such, Esperanza, additional, Barrera, Susana, additional, Ciudad, Juana, additional, Orfao, Alberto, additional, Maria Ribera, Josep, additional, Dávila Valls, Julio, additional, De Las Heras Rodriguez, Natalia, additional, Luis Fuster, José, additional, García de Coca, Alfonso, additional, Labrador, Jorge, additional, Antonio Queizan, Jose, additional, Carmen Mendoza, Mª, additional, Riesco, Susana, additional, Benito, Rocío, additional, and Hernández Rivas, Jesus, additional

Published
2023
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28. HHV8 and EBV‐negative primary effusion‐based lymphoma: A case report of a new provisional entity and review of literature

Author

Canelo‐Vilaseca, Marta, primary, Tapia, Gustavo, additional, Orna, Elisa, additional, Sorigué, Marc, additional, Granada, Isabel, additional, Palomar‐Muñoz, Azahara, additional, Castillo, Ana, additional, Grau, Javier, additional, Mesa, Alba, additional, Ribera, Josep‐Maria, additional, Sancho, Juan‐Manuel, additional, and Navarro, José‐Tomás, additional

Published
2023
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29. Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma

Author

Gonzalez-Montes, Yolanda, primary, Rodriguez-Romanos, Rocío, additional, Villavicencio, Alicia, additional, Osca-Gelis, Gemma, additional, González-Bártulos, Marta, additional, Llopis, Francesca, additional, Clapes, Victòria, additional, Oriol, Albert, additional, Sureda, Anna, additional, Escoda, Lourdes, additional, Sarrà, Josep, additional, Garzó, Ana, additional, Lloveras, Natàlia, additional, Díez, Isabel, additional, Granada, Isabel, additional, and Gallardo, David, additional

Published
2023
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30. BCL3-rearrangements in B-cell lymphoid neoplasms occur in two breakpoint clusters associated with different diseases

Author

Carbo-Meix, Anna, Guijarro, Francesca, Wang, Luojun, Grau, Marta, Royo, Romina, Frigola, Gerard, Playa-Albinyana, Heribert, Bühler, Marco M; https://orcid.org/0000-0003-0850-3326, Clot, Guillem, Duran-Ferrer, Marti, Lu, Junyan, Granada, Isabel, Baptista, Maria-Joao, Navarro, Jose-Tomas, Espinet, Blanca, Puiggros, Anna, Tapia, Gustavo, Bandiera, Laura, De Canal, Gabriella, Bonoldi, Emanuela, Climent, Fina, Ribera-Cortada, Inmaculada, Fernandez-Caballero, Mariana, De la Banda, Esmeralda, Do Nascimento, Janilson, Pineda, Alberto, Vela, Dolors, Rozman, Maria, Aymerich, Marta, Syrykh, Charlotte, Zenz, Thorsten; https://orcid.org/0000-0001-7890-9845, et al, Carbo-Meix, Anna, Guijarro, Francesca, Wang, Luojun, Grau, Marta, Royo, Romina, Frigola, Gerard, Playa-Albinyana, Heribert, Bühler, Marco M; https://orcid.org/0000-0003-0850-3326, Clot, Guillem, Duran-Ferrer, Marti, Lu, Junyan, Granada, Isabel, Baptista, Maria-Joao, Navarro, Jose-Tomas, Espinet, Blanca, Puiggros, Anna, Tapia, Gustavo, Bandiera, Laura, De Canal, Gabriella, Bonoldi, Emanuela, Climent, Fina, Ribera-Cortada, Inmaculada, Fernandez-Caballero, Mariana, De la Banda, Esmeralda, Do Nascimento, Janilson, Pineda, Alberto, Vela, Dolors, Rozman, Maria, Aymerich, Marta, Syrykh, Charlotte, Zenz, Thorsten; https://orcid.org/0000-0001-7890-9845, and et al

Abstract

The t(14;19)(q32;q13) often juxtaposes BCL3 with IGH resulting in overexpression of the gene. In contrast to other oncogenic translocations, BCL3-rearrangement (BCL3-R) has been associated with a broad spectrum of lymphoid neoplasms. Here we report an integrative whole-genome sequence, transcriptomic, and DNA methylation analysis of 13 lymphoid neoplasms with BCL3-R. The resolution of the breakpoints at single base-pair revealed that they occur in two clusters at 5' (n=9) and 3' (n=4) regions of BCL3 associated with two different biological and clinical entities. Both breakpoints were mediated by aberrant class switch recombination of the IGH locus. However, the 5' breakpoints (upstream) juxtaposed BCL3 next to an IGH enhancer leading to overexpression of the gene whereas the 3' breakpoints (downstream) positioned BCL3 outside the influence of the IGH and were not associated with its expression. Upstream BCL3-R tumors had unmutated IGHV, trisomy 12, and mutated genes frequently seen in CLL but had an atypical CLL morphology, immunophenotype, DNA methylome, and expression profile that differ from conventional CLL. In contrast, downstream BCL3-R neoplasms were atypical splenic or nodal marginal zone lymphomas (MZL) with mutated IGHV, complex karyotypes and mutated genes typical of MZL. Two of the latter 4 tumors transformed to a large B-cell lymphoma. We designed a novel FISH assay that recognizes the two different breakpoints and validated these findings in 17 independent tumors. Overall, upstream or downstream breakpoints of BCL3-R are mainly associated with two subtypes of lymphoid neoplasms with different (epi)genomic, expression, and clinicopathological features resembling atypical CLL and MZL, respectively.

Published
2023

33. Accesibilidad e inclusión en transporte: Análisis en ciudades latinoamericanas: Mapas de viaje: Santiago

Author

Hidalgo, Darío, primary, Pardo, Carlosfelipe, additional, Olivares Medina, Claudio, additional, Urbano, Camilo, additional, Tinjacá, Natalia, additional, Moscoso, Marina, additional, Granada, Isabel, additional, Rodríguez Porcel, Manuel, additional, Navas, Cristián, additional, Ramos, Camila, additional, Pedraza, Lauramaría, additional, Gutiérrez, María Clara, additional, Glen, Claudia, additional, and Sandoval, Diana, additional

Published
2020
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34. Accesibilidad e inclusión en transporte: Análisis en ciudades latinoamericanas: Mapas de viaje: Medellín

Author

Hidalgo, Darío, primary, Pardo, Carlosfelipe, additional, Olivares, Claudio, additional, Urbano, Camilo, additional, Tinjacá, Natalia, additional, Moscoso, Marina, additional, Granada, Isabel, additional, Rodríguez Porcel, Manuel, additional, Navas, Cristian, additional, Ramos, Camila, additional, Pedraza, Lauramaría, additional, Gutiérrez, María Clara, additional, Glen, Claudia, additional, and Sandoval, Diana, additional

Published
2020
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36. Pilot Inter-Laboratory Comparison Study of Optical Genome Mapping Analysis for Cytogenomic Characterization of Hematological Malignancies: A Spanish Multicentric Study

Author

Puiggros, Anna, primary, Mallo, Mar, additional, Salido, Marta, additional, Gómez-García, Ana, additional, Cisneros, Adela, additional, García-Serra, Rocío, additional, González-Gil, Celia, additional, Avetisyan, Gayane, additional, Rodríguez-Rivera, María, additional, Diaz-Gonzalez, Alvaro, additional, Granada, Isabel, additional, Such, Esperanza, additional, Genescà, Eulàlia, additional, Collado, Rosa, additional, Ramírez-Orellana, Manuel, additional, Solé, Francesc, additional, and Espinet, Blanca, additional

Published
2022
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37. IKZF1 Deletions Are Markers of Treatment Resistance in Adult Ph-Negative B-Cell Acute Lymphoblastic Leukemia Patients Treated within the Ongoing Risk-Adapted Pethema LAL19 Trial

Author

Ribera, Jordi, primary, Granada, Isabel, additional, González, Teresa, additional, Morgades, Mireia, additional, Garcia, Olga, additional, Sanchez, Ricardo, additional, Such, Esperanza, additional, Barrena, Susana, additional, Ciudad, Juana, additional, Soriano, Beatriz, additional, Benito, Rocio, additional, Avetisyan, Gayane, additional, Lumbreras, Eva, additional, Miguel-García, Cristina, additional, Santos-Mínguez, Sandra, additional, Zamora, Lurdes, additional, Mallo, Mar, additional, González-Gil, Celia, additional, Genescà, Eulàlia, additional, Lopes, Thaysa, additional, Hernández-Rivas, Jesus Maria, additional, Orfao, Alberto, additional, and Ribera, Josep-Maria, additional

Published
2022
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38. HHV8 and EBV negative primary effusion-based lymphoma: a case report of a new provisional entity and review of literature.

Author

Canelo-Vilaseca, Marta, primary, Melendo, Gustavo Tapia, additional, Orna, Elisa, additional, Sorigué, Marc, additional, Granada, Isabel, additional, Palomar-Muñoz, Azahara, additional, Castillo, Ana, additional, Grau, Javier, additional, Mesa, Alba, additional, Ribera, Josep-Maria, additional, Sancho, Juan Manuel, additional, and Navarro, Jose-Tomas, additional

Published
2022
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39. Poster: ALL-268 Genetic Classification of B-Cell Precursor Adult Acute Lymphoblastic Leukemia Patients Enrolled in LAL19 Trial from the Pethema Group: Response to Treatment and Survival

Author

Ribera, Jordi, primary, Granada, Isabel, additional, González, Teresa, additional, Morgades, Mireia, additional, Sánchez, Ricardo, additional, Such, Esperanza, additional, Barrena, Susana, additional, Ciudad, Juana, additional, Soriano, Beatriz, additional, Benito, Rocío, additional, Avetisyan, Gayane, additional, Lumbreras, Eva, additional, Miguel, Cristina, additional, Santos, Sandra, additional, Zamora, Lurdes, additional, Mallo, Mar, additional, Genescà, Eulàlia, additional, González, Celia, additional, Lopes, Thaysa, additional, Hernández-Rivas, Jesús-María, additional, Orfao, Alberto, additional, and Ribera, Josep Maria, additional

Published
2022
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40. Accesibilidad e inclusión en transporte: Análisis en ciudades latinoamericanas: Mapas de viaje: Bogotá

Author

Hidalgo, Darío, primary, Pardo, CarlosFelipe, additional, Olivares, Claudio, additional, Urbano, Camilo, additional, Tinjacá, Natalia, additional, Moscoso, Marina, additional, Granada, Isabel, additional, Rodriguez Porcel, Manuel, additional, Navas, Cristian, additional, Ramos, Camila, additional, Pedraza, Lauramaría, additional, Gutiérrez, Maria Clara, additional, Glen, Claudia, additional, and Sandoval, Diana, additional

Published
2019
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44. Género y transporte: Santiago

Author

Crotte Alvarado, Amado, primary, Granada, Isabel, additional, Ortiz, Paola, additional, Leaño, Juan Manuel, additional, Armijos, Jean Pol, additional, Sanz, Natalia, additional, Glen, Claudia, additional, Navas, Cristian, additional, Cortés, René, additional, and Benítez, Carolina, additional

Published
2019
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45. Género y transporte: Guatemala

Author

Granada, Isabel, primary, Leaño, Juan Manuel, additional, Benítez, Carolina, additional, Navas, Cristian, additional, Sanz, Natalia, additional, Crotte, Amado, additional, Cortés, René, additional, Armijos, Jean Pol, additional, Ortiz, Paola, additional, and Glen, Claudia, additional

Published
2019
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47. Participación femenina en el mercado laboral de transporte

Author

Crotte Alvarado, Amado, primary, Granada, Isabel, additional, Ortiz, Paola, additional, Leaño, Juan Manuel, additional, Armijos, Jean Pol, additional, Sanz, Natalia, additional, Glen, Claudia, additional, Navas, Cristian, additional, Cortés, René, additional, and Benítez, Carolina, additional

Published
2019
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48. P-203: Early mortality and treatment discontinuation in multiple myeloma patients treated in front-line with bortezomib, lenalidomide and dexamethasone (VRD)

Author

Oriol, Albert, primary, Canelo-Vilaseca, Marta, additional, Sanchez, Carla, additional, Abril, Laura, additional, Escoda, Lourdes, additional, Ibarra, Gladys, additional, Abella, Eugenia, additional, Motllo, Cristina, additional, Gonzalez-Montes, Yolanda, additional, Granada, Isabel, additional, Cabezudo, Elena, additional, Senin, Alicia, additional, Ben, Randa, additional, Jurado, Rebeca, additional, de Jaureguizar, Alejandro, additional, Ribera, Josep-Maria, additional, Sarra, Josep, additional, Sancho, Juan-Manuel, additional, and Sureda, Anna, additional

Published
2022
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49. Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome

Author

Sánchez-Castro, Judit, Marco-Betés, Víctor, Gómez-Arbonés, Xavier, Arenillas, Leonor, Valcarcel, David, Vallespí, Teresa, Costa, Dolors, Nomdedeu, Benet, Jimenez, María José, Granada, Isabel, Grau, Javier, Ardanaz, María T., de la Serna, Javier, Carbonell, Félix, Cervera, José, Sierra, Adriana, Luño, Elisa, Cervero, Carlos J., Falantes, José, Calasanz, María J., González-Porrás, José R., Bailén, Alicia, Amigo, M. Luz, Sanz, Guillermo, and Solé, Francesc

Published
2013
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50. Prognostic heterogeneity of adult B-cell precursor acute lymphoblastic leukaemia patients with t(1;19)(q23;p13)/TCF3-PBX1 treated with measurable residual disease-oriented protocols

Author

Generalitat de Catalunya, Fundación la Caixa, Ribera, Jordi, Granada, Isabel, Morgades, Mireia, González, Teresa, Ciudad, Juana, Such, Esperanza, Calasanz, Mª Jose, Mercadal, Santiago, Coll, Rosa, González-Campos, José A., Tormo, Mar, García-Cadenas, Irene, Gil, Cristina, Cervera, Marta, Barba, Pere, Costa, Dolors, Ayala Bueno, Rosa, Bermúdez, Arantxa, Orfao, Alberto, Ribera, Josep-Maria, Generalitat de Catalunya, Fundación la Caixa, Ribera, Jordi, Granada, Isabel, Morgades, Mireia, González, Teresa, Ciudad, Juana, Such, Esperanza, Calasanz, Mª Jose, Mercadal, Santiago, Coll, Rosa, González-Campos, José A., Tormo, Mar, García-Cadenas, Irene, Gil, Cristina, Cervera, Marta, Barba, Pere, Costa, Dolors, Ayala Bueno, Rosa, Bermúdez, Arantxa, Orfao, Alberto, and Ribera, Josep-Maria

Abstract

The prognosis of t(1;19)(q23;p13)/transcription factor 3-pre-B-cell leukaemia homeobox 1 (TCF3-PBX1) in adolescent and adult patients with acute lymphoblastic leukaemia (ALL) treated with measurable residual disease (MRD)-oriented trials remains controversial. In the present study, we analysed the outcome of adolescent and adult patients with t(1;19)(q23;p13) enrolled in paediatric-inspired trials. The patients with TCF3-PBX1 showed similar MRD clearance and did not have different survival compared with other B-cell precursor ALL patients. However, patients with TCF3-PBX1 had a significantly higher cumulative incidence of relapse, especially among patients aged ≥35 years carrying additional cytogenetic alterations. These patients might benefit from additional/intensified therapy (e.g. immunotherapy in first complete remission with or without subsequent haematopoietic stem cell transplantation).

Published
2022

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