930 results on '"Gralla J"'
Search Results
2. Contralateral Stenosis and Echolucent Plaque Morphology are Associated with Elevated Stroke Risk in Patients Treated with Asymptomatic Carotid Artery Stenosis within a Controlled Clinical Trial (SPACE-2)
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Beyersdorf, F, Grügerny, M, Macharzina, R-R, Lechner, G, Menz, C, Schonhardt, S, Weinbeck, M, Greb, O, Otto, D, Winker, T, Berger, H, Poppert, H, Pütz, V, Haase, K, Bodechtel, U, Weiss, N, Bergert, H, Meyne, J, Groß, J, Botsch, A, Kruse, M, Gerdes, B, Reinbold, WD, Wuttig, H, Maier-Hasselmann, A, Segerer, M, Fuchs, H-H, Gass, S, Schultz, H, Groden, C, Niedergethman, M, Griebe, M, Rosenkranz, M, Beck, C, Thomalla, G, Zeumer, H, Jauß, M, Kneist, W, Kneist, M, Staudacher, T, Bernhard, A, Jost, D, Prey, N, Knippschild, J, Kastrup, O, Köhrmann, M, Frank, B, Bongers, V, Hoffmann, J, Kniemeyer, H-W, Knauth, M, Wasser, K, Stojanovic, T, Emmert, H, Tacke, J, Schwalbe, B, Nam, E-M, van Lengerich, U, Lowens, S, Gröschel, K, Uphaus, T, Gröschel, S, Boor, S, Dorweiler, B, Schmid, E, Henkes, H, Hupp, T, Singer, O, Hamann, G, Wagner-Heck, M, Kerth-Krick, S, Kilic, M, Huppert, P, Niederkorn, K, Fruhwirth, J, Klein, G, Pulkowski, U, Jöster, K, Wacks, J-H, Kloppmann, E, Vatankhah, B, Hopf-Jensen, S, Stolze, H, Müller-Hülsbeck, S, Walluscheck, KP, Schmitt, H-M, Grüger, A, Seemann, J, Tilahun, B, Dichgans, M, Wollenweber, F, Dörr, A, Zollver, A, Gäbel, G, Hedtmann, G, Kollmar, R, Claus, D, Petermann, C, Kirsch, S, Bosnjak, B, Heiß, J, Mühling, H, Wunderlich, S, Sabisch, PN, Gahn, G, Storck, M, Arnold, S, Fischer, U, Gralla, J, von Mering, M, Dißmann, R, Kirsch, D, Schmidauer, C, Waldenberger, P, Furtner, M, Kazarians, H, Breuer, P, Arning, C, Rieper, J, Schmidt, G, Arnold, M, Schroth, G, Weise, J, Zanow, J, Mayer, T, Töpper, R, Gross-Fengels, W, Daum, H, Dittrich, R, Ritter, M, Kasprzak, B, Torsello, G, Pohlmann, C, Brüning, R, Amiri, H, Ludwig, I, Blessing, E, Möhlenbruch, M, Crispin, A, Hofman, M, Müller, T, Reiff, Tilman, Eckstein, Hans-Henning, Mansmann, Ulrich, Jansen, Olav, Fraedrich, Gustav, Mudra, Harald, Böckler, Dittmar, Böhm, Michael, Brückmann, Hartmut, Debus, E. Sebastian, Fiehler, Jens, Mathias, Klaus, Ringelstein, E. Bernd, Schmidli, Jürg, Stingele, Robert, Zahn, Ralf, Zeller, Thomas, Niesen, Wolf-Dirk, Barlinn, Kristian, Binder, Andreas, Glahn, Jörg, and Ringleb, Peter Arthur
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- 2021
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3. TICI and Age: What's the Score?
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Slater, LA, Coutinho, JM, Gralla, J, Nogueira, RG, Bonafé, A, Dávalos, A, Jahan, R, Levy, E, Baxter, BJ, Saver, JL, and Pereira, VM
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Clinical Research ,Adult ,Age Factors ,Aged ,Aged ,80 and over ,Cerebral Revascularization ,Clinical Trials as Topic ,Humans ,Middle Aged ,Prospective Studies ,Reperfusion ,Stroke ,Thrombectomy ,Treatment Outcome ,Young Adult ,STAR and SWIFT investigators ,Clinical Sciences ,Neurosciences ,Nuclear Medicine & Medical Imaging - Abstract
Background and purposePrevious studies have suggested that advanced age predicts worse outcome following mechanical thrombectomy. We assessed outcomes from 2 recent large prospective studies to determine the association among TICI, age, and outcome.Materials and methodsData from the Solitaire FR Thrombectomy for Acute Revascularization (STAR) trial, an international multicenter prospective single-arm thrombectomy study and the Solitaire arm of the Solitaire FR With the Intention For Thrombectomy (SWIFT) trial were pooled. TICI was determined by core laboratory review. Good outcome was defined as an mRS score of 0-2 at 90 days. We analyzed the association among clinical outcome, successful-versus-unsuccessful reperfusion (TICI 2b-3 versus TICI 0-2a), and age (dichotomized across the median).ResultsTwo hundred sixty-nine of 291 patients treated with Solitaire in the STAR and SWIFT data bases for whom TICI and 90-day outcome data were available were included. The median age was 70 years (interquartile range, 60-76 years) with an age range of 25-88 years. The mean age of patients 70 years of age or younger was 59 years, and it was 77 years for patients older than 70 years. There was no significant difference between baseline NIHSS scores or procedure time metrics. Hemorrhage and device-related complications were more common in the younger age group but did not reach statistical significance. In absolute terms, the rate of good outcome was higher in the younger population (64% versus 44%, P < .001). However, the magnitude of benefit from successful reperfusion was higher in the 70 years of age and older group (OR, 4.82; 95% CI, 1.32-17.63 versus OR 7.32; 95% CI, 1.73-30.99).ConclusionsSuccessful reperfusion is the strongest predictor of good outcome following mechanical thrombectomy, and the magnitude of benefit is highest in the patient population older than 70 years of age.
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- 2016
4. Mechanical Thrombectomy for Isolated M2 Occlusions: A Post Hoc Analysis of the STAR, SWIFT, and SWIFT PRIME Studies.
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Coutinho, JM, Liebeskind, DS, Slater, L-A, Nogueira, RG, Baxter, BW, Levy, EI, Siddiqui, AH, Goyal, M, Zaidat, OO, Davalos, A, Bonafé, A, Jahan, R, Gralla, J, Saver, JL, and Pereira, VM
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Animals ,Dogs ,Humans ,Brain Ischemia ,Infarction ,Middle Cerebral Artery ,Cerebral Hemorrhage ,Postoperative Complications ,Treatment Outcome ,Reperfusion ,Cerebral Revascularization ,Thrombectomy ,Prospective Studies ,Stents ,Aged ,Aged ,80 and over ,Middle Aged ,Female ,Male ,Multicenter Studies as Topic ,Stroke ,Neurosciences ,Clinical Sciences ,Nuclear Medicine & Medical Imaging - Abstract
Background and purposeMechanical thrombectomy is beneficial for patients with acute ischemic stroke and a proximal anterior occlusion, but it is unclear if these results can be extrapolated to patients with an M2 occlusion. The purpose of this study was to examine the technical aspects, safety, and outcomes of mechanical thrombectomy with a stent retriever in patients with an isolated M2 occlusion who were included in 3 large multicenter prospective studies.Materials and methodsWe included patients from the Solitaire Flow Restoration Thrombectomy for Acute Revascularization (STAR), Solitaire With the Intention For Thrombectomy (SWIFT), and Solitaire With the Intention for Thrombectomy as Primary Endovascular Treatment (SWIFT PRIME) studies, 3 large multicenter prospective studies on thrombectomy for ischemic stroke. We compared outcomes and technical details of patients with an M2 with those with an M1 occlusion. All patients were treated with a stent retriever. Imaging data and outcomes were scored by an independent core laboratory. Successful reperfusion was defined as modified Thrombolysis in Cerebral Infarction score of 2b/3.ResultsWe included 50 patients with an M2 and 249 patients with an M1 occlusion. Patients with an M2 occlusion were older (mean age, 71 versus 67 years; P = .04) and had a lower NIHSS score (median, 13 versus 17; P < .001) compared with those with an M1 occlusion. Procedural time was nonsignificantly shorter in patients with an M2 occlusion (median, 29 versus 35 minutes; P = .41). The average number of passes with a stent retriever was also nonsignificantly lower in patients with an M2 occlusion (mean, 1.4 versus 1.7; P = .07). There were no significant differences in successful reperfusion (85% versus 82%, P = .82), symptomatic intracerebral hemorrhages (2% versus 2%, P = 1.0), device-related serious adverse events (6% versus 4%, P = .46), or modified Rankin Scale score 0-2 at follow-up (60% versus 56%, P = .64).ConclusionsEndovascular reperfusion therapy appears to be feasible in selected patients with ischemic stroke and an M2 occlusion.
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- 2016
5. Survival Benefit of Repeat Liver Transplantation in the United States: A Serial MELD Analysis by Hepatitis C Status and Donor Risk Index
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Biggins, SW, Gralla, J, Dodge, JL, Bambha, KM, Tong, S, Barón, AE, Inadomi, J, Terrault, N, and Rosen, HR
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Infectious Diseases ,Liver Disease ,Digestive Diseases ,Chronic Liver Disease and Cirrhosis ,Transplantation ,Organ Transplantation ,Hepatitis - C ,Hepatitis ,Emerging Infectious Diseases ,Good Health and Well Being ,Adult ,End Stage Liver Disease ,Female ,Graft Rejection ,Hepatitis C ,Humans ,Liver Transplantation ,Male ,Middle Aged ,Reoperation ,Risk Factors ,Survival Analysis ,Tissue Donors ,United States ,Waiting Lists ,Health services and outcomes research ,liver transplantation ,hepatology ,recipient selection ,retransplantation ,liver transplantation/hepatology ,Medical and Health Sciences ,Surgery - Abstract
Survival benefit (SB) for first liver transplantation (LT) is favorable at Model for End-Stage Liver Disease (MELD)≥15. Herein, we identify the MELD threshold for SB from repeat liver transplantation (ReLT) by recipient hepatitis C virus (HCV) status and donor risk index (DRI). We analyzed lab MELD scores in new United Network for Organ Sharing registrants for ReLT from March 2002 to January 2010. Risk of ReLT graft failure≤1 year versus waitlist mortality was calculated using Cox regression, adjusting for recipient characteristics. Of 3057 ReLT candidates, 54% had HCV and 606 died while listed. There were 1985 ReLT recipients, 52% had HCV and 567 ReLT graft failures by 1 year. Unadjusted waitlist mortality and post-ReLT graft failure rates were 416 (95% confidence interval [CI] 384-450) and 375 (95% CI 345-407) per 1000 patient-years, respectively. Waitlist mortality was higher with increasing waitlist MELD (p
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- 2014
6. Clinical Significance of Pretransplant Donor-Specific Antibodies in the Setting of Negative Cell-Based Flow Cytometry Crossmatching in Kidney Transplant Recipients
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Adebiyi, O.O., Gralla, J., Klem, P., Freed, B., Davis, S., Wiseman, A.C., and Cooper, J.E.
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- 2016
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7. Perceived acceptable uncertainty regarding comparability of endovascular treatment alone versus intravenous thrombolysis plus endovascular treatment
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Kaesmacher, J, Mujanovic, A, Treurniet, K, Kappelhof, M, Meinel, TR, Yang, P, Liu, J, Zhang, Y, Zi, W, Yang, Q, Nogueira, RG, Kimura, K, Matsumaru, Y, Suzuki, K, Yan, B, Mitchell, PJ, Miao, Z, Roos, YBWEM, Majoie, CBLM, Gralla, J, Saver, JL, Fischer, U, Kaesmacher, J, Mujanovic, A, Treurniet, K, Kappelhof, M, Meinel, TR, Yang, P, Liu, J, Zhang, Y, Zi, W, Yang, Q, Nogueira, RG, Kimura, K, Matsumaru, Y, Suzuki, K, Yan, B, Mitchell, PJ, Miao, Z, Roos, YBWEM, Majoie, CBLM, Gralla, J, Saver, JL, and Fischer, U
- Abstract
BACKGROUND: Most trials comparing endovascular treatment (EVT) alone versus intravenous thrombolysis with alteplase (IVT) + EVT in directly admitted patients with a stroke are non-inferiority trials. However, the margin based on the level of uncertainty regarding non-inferiority of the experimental treatment that clinicians are willing to accept to incorporate EVT alone into clinical practice remains unknown. OBJECTIVE: To characterize what experienced stroke clinicians would consider an acceptable level of uncertainty for hypothetical decisions on whether to administer IVT or not before EVT in patients admitted directly to EVT-capable centers. METHODS: A web-based, structured survey was distributed to a cross-section of 600 academic neurologists/neurointerventionalists. For this purpose, a response framework for a hypothetical trial comparing IVT+EVT (standard of care) with EVT alone (experimental arm) was designed. In this trial, a similar proportion of patients in each arm achieved functional independence at 90 days. Invited physicians were asked at what level of certainty they would feel comfortable skipping IVT in clinical practice, considering these hypothetical trial results. RESULTS: There were 180 respondents (response rate: 30%) and 165 with complete answers. The median chosen acceptable uncertainty suggesting reasonable comparability between both treatments was an absolute difference in the rate of day 90 functional independence of 3% (mode 5%, IQR 1-5%), with higher chosen margins observed in interventionalists (aOR 2.20, 95% CI 1.06 to 4.67). CONCLUSION: Physicians would generally feel comfortable skipping IVT before EVT at different certainty thresholds. Most physicians would treat with EVT alone if randomized trial data suggested that the number of patients achieving functional independence at 90 days was similar between the two groups, and one could be sufficiently sure that no more than 3 out of 100 patients would not achieve functional independence
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- 2023
8. Intra-Arterial Thrombolysis is Associated with Delayed Reperfusion of Remaining Vessel Occlusions following Incomplete Thrombectomy.
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Mujanovic, A., Kurmann, C. C., Serrallach, B. L., Dobrocky, T., Meinel, T. R., Windecker, D., Grunder, L., Beyeler, M., Seiffge, D. J., Pilgram-Pastor, S., Arnold, M., Piechowiak, E. I., Gralla, J., Fischer, U., and Kaesmacher, J.
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- 2023
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9. Prodromal Transient Ischemic Attack or Minor Stroke and Outcome in Basilar Artery Occlusion
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Weber, A.M., Donnan, G.A., Thijs, V., Peeters, A., de Freitas, G.R., Conforto, A.B., Miranda-Alves, M., Massaro, A., Ijäs, P., Bogoslovsky, T., Lindsberg, P.J., Weimar, C., Benemann, J., Kraywinkel, K., Haverkamp, C., Michalski, D., Weissenborn, K., Goertler, M., Kloth, A., Bitsch, A., Mieck, T., Machetanz, J., Möller, P., Huber, R., Kaendler, S., Rueckert, C., Audebert, H., Müller, R., Vatankhah, B., Pfefferkorn, T., Mayer, T.E., Szabo, K., Disque, C., Busse, O., Berger, C., Hacke, W., Schwammenthal, Y., Orion, D., Tanne, D., Bergui, M., Pozzati, E., Schonewille, W.J., Algra, A., Kappelle, L.J., Luijckx, G.J., Vroomen, P., Vergouwen, M.D., Roos, Y., Stam, J., Bienfait, P., de Leeuw, F.E., de Kort, P., Dippel, D., Baird, T., Muir, K., Pagola, J., Ribo, M., Molina, C., Gonzales, A., Gil-Peralta, A., Norrving, B., Arnold, M., Fischer, U., Gralla, J., Mattle, H., Schroth, G., Michel, P., Engelter, S.T., Wetzel, S., Lyrer, P., Gandjour, J., Michael, N., Baumgartner, R., Tettenborn, B., Hungerbuehler, H., Wijman, C.A.C., Finley Caulfield, A., Lansberg, M., Schwartz, N., Venkatasubramanian, C., Garami, Z., Bogaard, S., Yatzu, F., Grotta, J., Conforto, Adriana B., de Freitas, Gabriel R., Schonewille, Wouter J., Kappelle, L. Jaap, and Algra, Ale
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- 2015
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10. Correlation of Collateral Scores Derived from Whole-Brain Time-Resolved Flat Panel Detector Imaging in Acute Ischemic Stroke
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Kurmann, C.C., primary, Kaesmacher, J., additional, Pilgram-Pastor, S., additional, Piechowiak, E.I., additional, Scutelnic, A., additional, Heldner, M.R., additional, Dobrocky, T., additional, Gralla, J., additional, and Mordasini, P., additional
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- 2022
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11. Mechanical properties of blood clots - A new test method -
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Monstadt, H., Krasokha, N., Dorn, F., Reese, S., Theisen, W., Mordasini, P., Breckenfeld, C., Gralla, J., Slotboom, J., Liebig, T., Schroth, G., Magjarevic, Ratko, Dössel, Olaf, editor, and Schlegel, Wolfgang C., editor
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- 2010
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12. Primary Results of the Multicenter ARISE II Study (Analysis of Revascularization in Ischemic Stroke With EmboTrap)
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Zaidat, Osama O., Bozorgchami, Hormozd, Ribó, Marc, Saver, Jeffrey L., Mattle, Heinrich P., Chapot, René, Narata, Ana Paula, Francois, Olivier, Jadhav, Ashutosh P., Grossberg, Jonathan A., Riedel, Christian H., Tomasello, Alejandro, Clark, Wayne M., Nordmeyer, Hannes, Lin, Eugene, Nogueira, Raul G., Yoo, Albert J., Jovin, Tudor G., Siddiqui, Adnan H., Bernard, Thierry, Claffey, Mairsíl, Andersson, Tommy, Ribo, M., Hetts, S., Hacke, W., Mehta, Brijesh, Hacein-Bey, L., Kim, A., Abou-Chebl, A., Shabe, P., Hetts, S., Hacein-Bey, L., Kim, A., Abou-Chebl, A., Dix, J., Gurian, J., Zink, W.E., Dabus, G., O’Leary, N., Reilly, A., Lee, K., Foley, J., Dolan, M., Hartley, E., Clark, T., Nadeau, K., Shama, J., Hull, L., Brown, B., Priest, R., Nesbit, G., Horikawa, M., Hoak, D., Petersen, B., Beadell, Noah, Herrick, Kory, White, C., Stacey, M., Ford, S., Liu, J., Ribó, M., Sanjuan, E., Sanchis, M., Molina, C., Rodríguez-Luna, D., Boned Riera, S., Pagola, J., Rubiera, M., Juega, J., Rodríguez, N., Muller, N., Stauder, M., Stracke, P., Heddier, M., Charron, V., Decock, A., Herbreteau, D., Bibi, R., De Sloovere, A.S., Doutreloigne, I., Pieters, D., Dewaele, T., Bourgeois, P., Vanhee, F., Vanderdouckt, P., Vancaster, E., Baxendell, L., Gilchrist, V., Cannon, Y., Graves, C., Armbruster, K., Jovin, T., Jankowitz, B., Ducruet, A., Aghaebrahim, A., Kenmuir, C., Shoirah, H., Molyneaux, B., Tadi, P., Walker, G., Starr, M., Doppelheuer, S., Schindler, K., Craft, L., Schultz, M., Perez, H., Park, J., Hall, A., Mitchell, A., Webb, L., Haussen, D., Frankel, M., Bianchi, N., Belagaje, S., Mahdi, N., Lahoti, S., Katema, A., Winningham, M., Anderson, A., Tilley, D.A., Steinhauser, T., Scott, D., Thacker, A., Calderon, V., Lin, E., Becke, S., Krieter, S., Jansen, O., Wodarg, F., Larsen, N., Binder, A., Wiesen, C., Hartney, M., Bookhagan, L., Ross, H., Gay, J., Snyder, K., Levy, E., Davies, J., Sonig, A., Rangel-Castilla, L., Mowla, A., Shakir, H., Fennell, V., Atwal, G., Natarajan, S., Beecher, J., Thornton, J., Cullen, A., Brennan, P., O’Hare, A., Asadi, H., Budzik, R., Taylor, M., Jennings, M., Laube, F., Jackson, J., Gatrell, R., Reebel, L., Albon, A., Gerniak, J., Groezinger, K., Lauf, M., Voraco, N., Pema, P., Davis, T., Hicks, W., Mejilla, J., Teleb, M., Sunenshine, P., Russo, E., Flynn, R., Twyford, J., Ver Hage, A., Smith, E., Apolinar, L., Blythe, S., Maxan, J., Carter, J., Taschner, T., Bergmann, U., Meckel, S., Elsheik, S., Urbach, H., Maurer, C., Egger, K., Niesen, W.D., Baxter, B.W., Knox, A., Hazelwood, B., Quarfordt, S., Calvert, J., Hawk, H., Malek, R., Padidar, A., Tolley, U., Gutierrez, A., Mordasini, P., Seip, T., Balasubramaniam, R., Gralla, J., Fischer, U., Zibold, F., Piechowiak, E., DeLeacy, R., Apruzzeses, R., Alfonso, C., Haslett, J., Fifi, J., Mocco, J., Starkman, S., Guzy, J., Grunberg, N., Szeder, V., Tateshima, S., Duckwiler, G., Nour, M., Liebeskind, D., Tang, X., Hinman, J., Tipirneni, A., Yavagal, D., Guada, L., Bates, K., Balladeras, S., Bokka, S.K., Suir, S., Caplan, J., Kandewall, P., Peterson, E., Starke, R.M., Puri, A., Hawk, M., Brooks, C., L’Heurex, J., Ty, K., Rex, D., Massari, F., Wakhloo, A., Lozano, D., Rodrigua, K.D., Pierot, L., Fabienne, M., Sebastien, S., and Emmoinoli, M.G.
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- 2018
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13. Neuroradiological Emergency Interventions
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Brekenfeld, C., Gralla, J., Wiest, R., El-Koussy, M., Remonda, L., Ozdoba, C., Schroth, G., Marincek, Borut, editor, and Dondelinger, Robert F., editor
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- 2007
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14. Training guidelines for endovascular stroke intervention: an international multi-society consensus document
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Lavine, S. D., Cockroft, K., Hoh, B., Bambakidis, N., Khalessi, A. A., Woo, H., Riina, H., Siddiqui, A., Hirsch, J. A., Chong, W., Rice, H., Wenderoth, J., Mitchell, P., Coulthard, A., Signh, T. J., Phatorous, C., Khangure, M., Klurfan, P., ter Brugge, K., Iancu, D, Gunnarsson, T., Jansen, O., Muto, M., Szikora, I., Pierot, L., Brouwer, P., Gralla, J., Renowden, S., Andersson, T., Fiehler, J., Turjman, F., White, P., Januel, A. C., Spelle, L., Kulcsar, Z., Chapot, R., Biondi, A., Dima, S., Taschner, C., Szajner, M., Krajina, A., Sakai, N., Matsumaru, Y., Yoshimura, S., Ezura, M., Fujinaka, T., Iihara, K., Ishii, A., Higashi, T., Hirohata, M., Hyodo, A., Ito, Y., Kawanishi, M., Kiyosue, H., Kobayashi, E., Kobayashi, S., Kuwayama, N., Matsumoto, Y., Miyachi, S., Murayama, Y., Nagata, I., Nakahara, I., Nemoto, S., Niimi, Y., Oishi, H., Satomi, J., Satow, T., Sugiu, K., Tanaka, M., Terada, T., Yamagami, H., Diaz, O., Lylyk, P., Jayaraman, M. V., Patsalides, A., Gandhi, C. D., Lee, S. K., Abruzzo, T., Albani, B., Ansari, S. A., Arthur, A. S., Baxter, B. W., Bulsara, K. R., Chen, M., Almandoz, J. E. Delgado, Fraser, J. F., Heck, D. V., Hetts, S. W., Hussain, M. S., Klucznik, R. P., Leslie-Mawzi, T. M., Mack, W. J., McTaggart, R. A., Meyers, P. M., Mocco, J., Prestigiacomo, C. J., Pride, G. L., Rasmussen, P. A., Starke, R. M., Sunenshine, P. J., Tarr, R. W., Frei, D. F., Ribo, M., Nogueira, R. G., Zaidat, O. O., Jovin, T., Linfante, I., Yavagal, D., Liebeskind, D., Novakovic, R., Pongpech, S., Rodesch, G., Soderman, M., Taylor, A., Krings, T., Orbach, D., Picard, L., Suh, D. C., and Zhang, H. Q.
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- 2016
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15. P35 Benefit of advanced 3D DSA and MRI/CT fusion in neurovascular pathology
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Dobrocky, T, primary, Piechowiak, E, additional, Mordasini, P, additional, and Gralla, J, additional
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- 2022
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16. P57 AIR GAP in neurointerventions – a reduction of radiation dose and exposure
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Pilgram-Pastor, S, primary, Slotboom, J, additional, Branca, M, additional, Piechowiak, EI, additional, Dobrocky, T, additional, Petroulia, V, additional, Kaesmacher, J, additional, Gralla, J, additional, and Mordasini, P, additional
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- 2022
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17. E-262 Benefit of advanced 3D DSA and MRI/CT fusion in neurovascular pathology
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Dobrocky, T, primary, Piechowiak, E, additional, Bervini, D, additional, Mordasini, P, additional, and Gralla, J, additional
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- 2022
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18. Endovascular Treatment of Acute Stroke: Evolution and Selection of Techniques and Instruments Based on Thrombus Imaging
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Liebig, T., Gralla, J., and Schroth, Gerhard
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- 2015
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19. Time to treatment with bridging intravenous alteplase before endovascular treatment: subanalysis of the randomized controlled SWIFT-DIRECT trial
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Meinel, TR, Kaesmacher, J, Buetikofer, L, Strbian, D, Eker, OF, Cognard, C, Mordasini, P, Deppeler, S, Pereira, VM, Albucher, JF, Darcourt, J, Bourcier, R, Guillon, B, Papagiannaki, C, Costentin, G, Sibolt, G, Raty, S, Gory, B, Richard, S, Liman, J, Ernst, M, Boulanger, M, Barbier, C, Mechtouff, L, Zhang, LQ, Marnat, G, Sibon, I, Nikoubashman, O, Reich, A, Consoli, A, Weisenburger, D, Requena, M, Garcia-Tornel, A, Saleme, S, Moulin, S, Pagano, P, Saliou, G, Carrera, E, Janot, K, Boix, M, Pop, R, Della Schiava, L, Luft, A, Piotin, M, Gentric, JC, Pikula, A, Pfeilschifter, W, Arnold, M, Siddiqui, A, Froehler, MT, Furlan, AJ, Chapot, R, Wiesmann, M, Machi, P, Diener, HC, Kulcsar, Z, Bonati, L, Bassetti, C, Escalard, S, Liebeskind, D, Saver, JL, Fischer, U, and Gralla, J
- Abstract
Background We hypothesized that treatment delays might be an effect modifier regarding risks and benefits of intravenous thrombolysis (IVT) before mechanical thrombectomy (MT). Methods We used the dataset of the SWIFT-DIRECT trial, which randomized 408 patients to IVT+MT or MT alone. Potential interactions between assignment to IVT+MT and expected time from onset-to-needle (OTN) as well as expected time from door-to-needle (DTN) were included in regression models. The primary outcome was functional independence (modified Rankin Scale (mRS) 0-2) at 3 months. Secondary outcomes included mRS shift, mortality, recanalization rates, and (symptomatic) intracranial hemorrhage at 24 hours. Results We included 408 patients (IVT+MT 207, MT 201, median age 72 years (IQR 64-81), 209 (51.2%) female). The expected median OTN and DTN were 142 min and 54 min in the IVT+MT group and 129 min and 51 min in the MT alone group. Overall there was no significant interaction between OTN and bridging IVT assignment regarding either the functional (adjusted OR (aOR) 0.76, 95% CI 0.45 to 1.30) and safety outcomes or the recanalization rates. Analysis of in-hospital delays showed no significant interaction between DTN and bridging IVT assignment regarding the dichotomized functional outcome (aOR 0.48, 95% CI 0.14 to 1.62), but the shift and mortality analyses suggested a greater benefit of IVT when in-hospital delays were short. Conclusions We found no evidence that the effect of bridging IVT on functional independence is modified by overall or in-hospital treatment delays. Considering its low power, this subgroup analysis could have missed a clinically important effect, and exploratory analysis of secondary clinical outcomes indicated a potentially favorable effect of IVT with shorter in-hospital delays. Heterogeneity of the IVT effect size before MT should be further analyzed in individual patient meta-analysis of comparable trials.
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- 2022
20. Stent-Retriever Thrombectomy: Impact on the Future of Interventional Stroke Treatment
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Mordasini, P., Zubler, C., Wha-Vei Hsieh, K., Chan, P. K., and Gralla, J.
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- 2014
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21. Risks of Undersizing Stent Retriever Length Relative to Thrombus Length in Patients with Acute Ischemic Stroke
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Belachew, N.F., primary, Dobrocky, T., additional, Meinel, T.R., additional, Hakim, A., additional, Vynckier, J., additional, Arnold, M., additional, Seiffge, D.J., additional, Wiest, R., additional, Piechowiak, E.I., additional, Fischer, U., additional, Gralla, J., additional, Mordasini, P., additional, and Kaesmacher, J., additional
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- 2021
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22. Evolution of MRI Findings in Patients with Idiopathic Intracranial Hypertension after Venous Sinus Stenting
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Belachew, N.F., primary, Almiri, W., additional, Encinas, R., additional, Hakim, A., additional, Baschung, S., additional, Kaesmacher, J., additional, Dobrocky, T., additional, Schankin, C.J., additional, Abegg, M., additional, Piechowiak, E.I., additional, Raabe, A., additional, Gralla, J., additional, and Mordasini, P., additional
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- 2021
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23. SWI Susceptibility Vessel Sign in Patients Undergoing Mechanical Thrombectomy for Acute Ischemic Stroke
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Belachew, N.F., primary, Dobrocky, T., additional, Aleman, E.B., additional, Meinel, T.R., additional, Hakim, A., additional, Vynckier, J., additional, Arnold, M., additional, Seiffge, D.J., additional, Wiest, R., additional, Mordasini, P., additional, Gralla, J., additional, Fischer, U., additional, Piechowiak, E.I., additional, and Kaesmacher, J., additional
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- 2021
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24. Contralateral Stenosis and Echolucent Plaque Morphology are Associated with Elevated Stroke Risk in Patients Treated with Asymptomatic Carotid Artery Stenosis within a Controlled Clinical Trial (SPACE-2)
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Reiff, Tilman, primary, Eckstein, Hans-Henning, additional, Mansmann, Ulrich, additional, Jansen, Olav, additional, Fraedrich, Gustav, additional, Mudra, Harald, additional, Böckler, Dittmar, additional, Böhm, Michael, additional, Brückmann, Hartmut, additional, Debus, E. Sebastian, additional, Fiehler, Jens, additional, Mathias, Klaus, additional, Ringelstein, E. Bernd, additional, Schmidli, Jürg, additional, Stingele, Robert, additional, Zahn, Ralf, additional, Zeller, Thomas, additional, Niesen, Wolf-Dirk, additional, Barlinn, Kristian, additional, Binder, Andreas, additional, Glahn, Jörg, additional, Ringleb, Peter Arthur, additional, Beyersdorf, F, additional, Grügerny, M, additional, Macharzina, R-R, additional, Lechner, G, additional, Menz, C, additional, Schonhardt, S, additional, Weinbeck, M, additional, Greb, O, additional, Otto, D, additional, Winker, T, additional, Berger, H, additional, Poppert, H, additional, Pütz, V, additional, Haase, K, additional, Bodechtel, U, additional, Weiss, N, additional, Bergert, H, additional, Meyne, J, additional, Groß, J, additional, Botsch, A, additional, Kruse, M, additional, Gerdes, B, additional, Reinbold, WD, additional, Wuttig, H, additional, Maier-Hasselmann, A, additional, Segerer, M, additional, Fuchs, H-H, additional, Gass, S, additional, Schultz, H, additional, Groden, C, additional, Niedergethman, M, additional, Griebe, M, additional, Rosenkranz, M, additional, Beck, C, additional, Thomalla, G, additional, Zeumer, H, additional, Jauß, M, additional, Kneist, W, additional, Kneist, M, additional, Staudacher, T, additional, Bernhard, A, additional, Jost, D, additional, Prey, N, additional, Knippschild, J, additional, Kastrup, O, additional, Köhrmann, M, additional, Frank, B, additional, Bongers, V, additional, Hoffmann, J, additional, Kniemeyer, H-W, additional, Knauth, M, additional, Wasser, K, additional, Stojanovic, T, additional, Emmert, H, additional, Tacke, J, additional, Schwalbe, B, additional, Nam, E-M, additional, van Lengerich, U, additional, Lowens, S, additional, Gröschel, K, additional, Uphaus, T, additional, Gröschel, S, additional, Boor, S, additional, Dorweiler, B, additional, Schmid, E, additional, Henkes, H, additional, Hupp, T, additional, Singer, O, additional, Hamann, G, additional, Wagner-Heck, M, additional, Kerth-Krick, S, additional, Kilic, M, additional, Huppert, P, additional, Niederkorn, K, additional, Fruhwirth, J, additional, Klein, G, additional, Pulkowski, U, additional, Jöster, K, additional, Wacks, J-H, additional, Kloppmann, E, additional, Vatankhah, B, additional, Hopf-Jensen, S, additional, Stolze, H, additional, Müller-Hülsbeck, S, additional, Walluscheck, KP, additional, Schmitt, H-M, additional, Grüger, A, additional, Seemann, J, additional, Tilahun, B, additional, Dichgans, M, additional, Wollenweber, F, additional, Dörr, A, additional, Zollver, A, additional, Gäbel, G, additional, Hedtmann, G, additional, Kollmar, R, additional, Claus, D, additional, Petermann, C, additional, Kirsch, S, additional, Bosnjak, B, additional, Heiß, J, additional, Mühling, H, additional, Wunderlich, S, additional, Sabisch, PN, additional, Gahn, G, additional, Storck, M, additional, Arnold, S, additional, Fischer, U, additional, Gralla, J, additional, von Mering, M, additional, Dißmann, R, additional, Kirsch, D, additional, Schmidauer, C, additional, Waldenberger, P, additional, Furtner, M, additional, Kazarians, H, additional, Breuer, P, additional, Arning, C, additional, Rieper, J, additional, Schmidt, G, additional, Arnold, M, additional, Schroth, G, additional, Weise, J, additional, Zanow, J, additional, Mayer, T, additional, Töpper, R, additional, Gross-Fengels, W, additional, Daum, H, additional, Dittrich, R, additional, Ritter, M, additional, Kasprzak, B, additional, Torsello, G, additional, Pohlmann, C, additional, Brüning, R, additional, Amiri, H, additional, Ludwig, I, additional, Blessing, E, additional, Möhlenbruch, M, additional, Crispin, A, additional, Hofman, M, additional, and Müller, T, additional
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- 2021
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25. New ischaemic brain lesions in cervical artery dissection stratified to antiplatelets or anticoagulants
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Gensicke, H., Ahlhelm, F., Jung, S., von Hessling, A., Traenka, C., Goeggel Simonetti, B., Peters, N., Bonati, L. H., Fischer, U., Broeg-Morvay, A., Seiffge, D. J., Gralla, J., Stippich, C., Baumgartner, R. W., Lyrer, P. A., Arnold, M., and Engelter, S. T.
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- 2015
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26. Statement of ESMINT and ESNR regarding recent trials evaluating the endovascular treatment at the acute stage of ischemic stroke
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Pierot, L., Söderman, M., Bendszus, M., White, P., Muto, M., Turjman, F., Mangiafico, S., Gralla, J., Fiehler, J., Szikora, I., and Cognard, C.
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- 2013
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27. Thrombolysis in patients with prior stroke within the last 3 months
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Heldner, M. R., Mattle, H. P., Jung, S., Fischer, U., Gralla, J., Zubler, C., El-Koussy, M., Schroth, G., Arnold, M., and Mono, M.-L.
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- 2014
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28. Bow Hunter’s Stroke Due to Prominent Degenerative Spinal Disorder
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Andereggen, L., Arnold, M., Andres, R. H., Raabe, A., Reinert, M., and Gralla, J.
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- 2012
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29. EP44* Nimbus geometric clot extractor for tough clots – Real world clinical experience and clot composition
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Nordmeyer, H, primary, Doyle, K, additional, Gralla, J, additional, Phung, T, additional, Molina Gil, S, additional, Belachew, NF, additional, Neuhaus, S, additional, Douglas, A, additional, and Mordasini, P, additional
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- 2021
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30. EP35 7 T MR imaging of small incidental unruptured intracranial aneurysms: first year of clinical experience
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Radojewski, P, primary, Slotboom, J, additional, Joseph, A, additional, Bonanno, G, additional, Dobrocky, T, additional, Bervini, D, additional, Raabe, A, additional, Wiest, R, additional, Gralla, J, additional, and Mordasini, P, additional
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- 2021
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31. Thrombectomy for Primary Distal Posterior Cerebral Artery Occlusion Stroke: The TOPMOST Study
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Meyer, L. Stracke, C.P. Jungi, N. Wallocha, M. Broocks, G. Sporns, P.B. Maegerlein, C. Dorn, F. Zimmermann, H. Naziri, W. Abdullayev, N. Kabbasch, C. Behme, D. Jamous, A. Maus, V. Fischer, S. Möhlenbruch, M. Weyland, C.S. Langner, S. Meila, D. Miszczuk, M. Siebert, E. Lowens, S. Krause, L.U. Yeo, L.L.L. Tan, B.Y.-Q. Anil, G. Gory, B. Galván, J. Arteaga, M.S. Navia, P. Raz, E. Shapiro, M. Arnberg, F. Zeleňák, K. Martinez-Galdamez, M. Fischer, U. Kastrup, A. Roth, C. Papanagiotou, P. Kemmling, A. Gralla, J. Psychogios, M.-N. Andersson, T. Chapot, R. Fiehler, J. Kaesmacher, J. Hanning, U.
- Abstract
Importance: Clinical evidence of the potential treatment benefit of mechanical thrombectomy for posterior circulation distal, medium vessel occlusion (DMVO) is sparse. Objective: To investigate the frequency as well as the clinical and safety outcomes of mechanical thrombectomy for isolated posterior circulation DMVO stroke and to compare them with the outcomes of standard medical treatment with or without intravenous thrombolysis (IVT) in daily clinical practice. Design, Setting, and Participants: This multicenter case-control study analyzed patients who were treated for primary distal occlusion of the posterior cerebral artery (PCA) of the P2 or P3 segment. These patients received mechanical thrombectomy or standard medical treatment (with or without IVT) at 1 of 23 comprehensive stroke centers in Europe, the United States, and Asia between January 1, 2010, and June 30, 2020. All patients who met the inclusion criteria were matched using 1:1 propensity score matching. Interventions: Mechanical thrombectomy or standard medical treatment with or without IVT. Main Outcomes and Measures: Clinical end point was the improvement of National Institutes of Health Stroke Scale (NIHSS) scores at discharge from baseline. Safety end point was the occurrence of symptomatic intracranial hemorrhage and hemorrhagic complications were classified based on the Second European-Australasian Acute Stroke Study (ECASSII). Functional outcome was evaluated with the modified Rankin Scale (mRS) score at 90-day follow-up. Results: Of 243 patients from all participating centers who met the inclusion criteria, 184 patients were matched. Among these patients, the median (interquartile range [IQR]) age was 74 (62-81) years and 95 (51.6%) were female individuals. Posterior circulation DMVOs were located in the P2 segment of the PCA in 149 patients (81.0%) and in the P3 segment in 35 patients (19.0%). At discharge, the mean NIHSS score decrease was -2.4 points (95% CI, -3.2 to -1.6) in the standard medical treatment cohort and -3.9 points (95% CI, -5.4 to -2.5) in the mechanical thrombectomy cohort, with a mean difference of -1.5 points (95% CI, 3.2 to -0.8; P =.06). Significant treatment effects of mechanical thrombectomy were observed in the subgroup of patients who had higher NIHSS scores on admission of 10 points or higher (mean difference, -5.6; 95% CI, -10.9 to -0.2; P =.04) and in the subgroup of patients without IVT (mean difference, -3.0; 95% CI, -5.0 to -0.9; P =.005). Symptomatic intracranial hemorrhage occurred in 4 of 92 patients (4.3%) in each treatment cohort. Conclusions and Relevance: This study suggested that, although rarely performed at comprehensive stroke centers, mechanical thrombectomy for posterior circulation DMVO is a safe, and technically feasible treatment option for occlusions of the P2 or P3 segment of the PCA compared with standard medical treatment with or without IVT.. © 2021 American Medical Association. All rights reserved.
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- 2021
32. EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients (EVA-TRISP) registry: Basis and methodology of a pan-European prospective ischaemic stroke revascularisation treatment registry
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Nordanstig, A. Curtze, S. Gensicke, H. Zinkstok, S.M. Erdur, H. Karlsson, C. Karlsson, J.-E. Martinez-Majander, N. Sibolt, G. Lyrer, P. Traenka, C. Baharoglu, M.I. Scheitz, J.F. Bricout, N. Hénon, H. Leys, D. Eskandari, A. Michel, P. Hametner, C. Ringleb, P.A. Arnold, M. Fischer, U. Sarikaya, H. Seiffge, D.J. Pezzini, A. Zini, A. Padjen, V. Jovanovic, D.R. Luft, A. Wegener, S. Kellert, L. Feil, K. Kägi, G. Rentzos, A. Lappalainen, K. Leker, R.R. Cohen, J.E. Gomori, J. Brehm, A. Liman, J. Psychogios, M. Kastrup, A. Papanagiotou, P. Gralla, J. Magoni, M. Majoie, C.B.L.M. Bohner, G. Vukasinovic, I. Cvetic, V. Weber, J. Kulcsar, Z. Bendszus, M. Möhlenbruch, M. Ntaios, G. Kapsalaki, E. Jood, K. Nolte, C.H. Nederkoorn, P.J.J. Engelter, S. Strbian, D. Tatlisumak, T.
- Abstract
Purpose The Thrombolysis in Ischemic Stroke Patients (TRISP) collaboration was a concerted effort initiated in 2010 with the purpose to address relevant research questions about the effectiveness and safety of intravenous thrombolysis (IVT). The collaboration also aims to prospectively collect data on patients undergoing endovascular treatment (EVT) and hence the name of the collaboration was changed from TRISP to EVA-TRISP. The methodology of the former TRISP registry for patients treated with IVT has already been published. This paper focuses on describing the EVT part of the registry. Participants All centres committed to collecting predefined variables on consecutive patients prospectively. We aim for accuracy and completeness of the data and to adapt local databases to investigate novel research questions. Herein, we introduce the methodology of a recently constructed academic investigator-initiated open collaboration EVT registry built as an extension of an existing IVT registry in patients with acute ischaemic stroke (AIS). Findings to date Currently, the EVA-TRISP network includes 20 stroke centres with considerable expertise in EVT and maintenance of high-quality hospital-based registries. Following several successful randomised controlled trials (RCTs), many important clinical questions remain unanswered in the (EVT) field and some of them will unlikely be investigated in future RCTs. Prospective registries with high-quality data on EVT-treated patients may help answering some of these unanswered issues, especially on safety and efficacy of EVT in specific patient subgroups. Future plans This collaborative effort aims at addressing clinically important questions on safety and efficacy of EVT in conditions not covered by RCTs. The TRISP registry generated substantial novel data supporting stroke physicians in their daily decision making considering IVT candidate patients. While providing observational data on EVT in daily clinical practice, our future findings may likewise be hypothesis generating for future research as well as for quality improvement (on EVT). The collaboration welcomes participation of further centres willing to fulfill the commitment and the outlined requirements. © 2021 BMJ Publishing Group. All rights reserved.
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- 2021
33. Global impact of COVID-19 on stroke care
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Nogueira, R.G. Abdalkader, M. Qureshi, M.M. Frankel, M.R. Mansour, O.Y. Yamagami, H. Qiu, Z. Farhoudi, M. Siegler, J.E. Yaghi, S. Raz, E. Sakai, N. Ohara, N. Piotin, M. Mechtouff, L. Eker, O. Chalumeau, V. Kleinig, T.J. Pop, R. Liu, J. Winters, H.S. Shang, X. Vasquez, A.R. Blasco, J. Arenillas, J.F. Martinez-Galdamez, M. Brehm, A. Psychogios, M.-N. Lylyk, P. Haussen, D.C. Al-Bayati, A.R. Mohammaden, M.H. Fonseca, L. Luís Silva, M. Montalverne, F. Renieri, L. Mangiafico, S. Fischer, U. Gralla, J. Frei, D. Chugh, C. Mehta, B.P. Nagel, S. Mohlenbruch, M. Ortega-Gutierrez, S. Farooqui, M. Hassan, A.E. Taylor, A. Lapergue, B. Consoli, A. Campbell, B.C.V. Sharma, M. Walker, M. Van Horn, N. Fiehler, J. Nguyen, H.T. Nguyen, Q.T. Watanabe, D. Zhang, H. Le, H.V. Nguyen, V.Q. Shah, R. Devlin, T. Khandelwal, P. Linfante, I. Izzath, W. Lavados, P.M. Olavarría, V.V. Sampaio Silva, G. de Carvalho Sousa, A.V. Kirmani, J. Bendszus, M. Amano, T. Yamamoto, R. Doijiri, R. Tokuda, N. Yamada, T. Terasaki, T. Yazawa, Y. Morris, J.G. Griffin, E. Thornton, J. Lavoie, P. Matouk, C. Hill, M.D. Demchuk, A.M. Killer-Oberpfalzer, M. Nahab, F. Altschul, D. Ramos-Pachón, A. Pérez de la Ossa, N. Kikano, R. Boisseau, W. Walker, G. Cordina, S.M. Puri, A. Luisa Kuhn, A. Gandhi, D. Ramakrishnan, P. Novakovic-White, R. Chebl, A. Kargiotis, O. Czap, A. Zha, A. Masoud, H.E. Lopez, C. Ozretic, D. Al-Mufti, F. Zie, W. Duan, Z. Yuan, Z. Huang, W. Hao, Y. Luo, J. Kalousek, V. Bourcier, R. Guile, R. Hetts, S. Al-Jehani, H.M. AlHazzani, A. Sadeghi-Hokmabadi, E. Teleb, M. Payne, J. Lee, J.S. Hong, J.M. Sohn, S.-I. Hwang, Y.-H. Shin, D.H. Roh, H.G. Edgell, R. Khatri, R. Smith, A. Malik, A. Liebeskind, D. Herial, N. Jabbour, P. Magalhaes, P. Ozdemir, A.O. Aykac, O. Uwatoko, T. Dembo, T. Shimizu, H. Sugiura, Y. Miyashita, F. Fukuda, H. Miyake, K. Shimbo, J. Sugimura, Y. Beer-Furlan, A. Joshi, K. Catanese, L. Abud, D.G. Neto, O.G. Mehrpour, M. Al Hashmi, A. Saqqur, M. Mostafa, A. Fifi, J.T. Hussain, S. John, S. Gupta, R. Sivan-Hoffmann, R. Reznik, A. Sani, A.F. Geyik, S. Akıl, E. Churojana, A. Ghoreishi, A. Saadatnia, M. Sharifipour, E. Ma, A. Faulder, K. Wu, T. Leung, L. Malek, A. Voetsch, B. Wakhloo, A. Rivera, R. Barrientos Iman, D.M. Pikula, A. Lioutas, V.-A. Thomalla, G. Birnbaum, L. Machi, P. Bernava, G. McDermott, M. Kleindorfer, D. Wong, K. Patterson, M.S. Fiorot, J.A., Jr. Huded, V. Mack, W. Tenser, M. Eskey, C. Multani, S. Kelly, M. Janardhan, V. Cornett, O. Singh, V. Murayama, Y. Mokin, M. Yang, P. Zhang, X. Yin, C. Han, H. Peng, Y. Chen, W. Crosa, R. Frudit, M.E. Pandian, J.D. Kulkarni, A. Yagita, Y. Takenobu, Y. Matsumaru, Y. Yamada, S. Kono, R. Kanamaru, T. Yamazaki, H. Sakaguchi, M. Todo, K. Yamamoto, N. Sonoda, K. Yoshida, T. Hashimoto, H. Nakahara, I. Cora, E. Volders, D. Ducroux, C. Shoamanesh, A. Ospel, J. Kaliaev, A. Ahmed, S. Rashid, U. Rebello, L.C. Pereira, V.M. Fahed, R. Chen, M. Sheth, S.A. Palaiodimou, L. Tsivgoulis, G. Chandra, R. Koyfman, F. Leung, T. Khosravani, H. Dharmadhikari, S. Frisullo, G. Calabresi, P. Tsiskaridze, A. Lobjanidze, N. Grigoryan, M. Czlonkowska, A. de Sousa, D.A. Demeestere, J. Liang, C. Sangha, N. Lutsep, H.L. Ayo-Martín, Ó. Cruz-Culebras, A. Tran, A.D. Young, C.Y. Cordonnier, C. Caparros, F. De Lecinana, M.A. Fuentes, B. Yavagal, D. Jovin, T. Spelle, L. Moret, J. Khatri, P. Zaidat, O. Raymond, J. Martins, S. Nguyen, T.
- Abstract
Background: The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide. Aims: We sought to measure the global impact of the COVID-19 pandemic on the volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at the height of the pandemic (1 March–31 May 2020) compared with two control three-month periods (immediately preceding and one year prior). Methods: Retrospective, observational, international study, across 6 continents, 40 countries, and 187 comprehensive stroke centers. The diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases at participating centers. Results: The hospitalization volumes for any stroke, intracranial hemorrhage, and mechanical thrombectomy were 26,699, 4002, and 5191 in the three months immediately before versus 21,576, 3540, and 4533 during the first three pandemic months, representing declines of 19.2% (95%CI, −19.7 to −18.7), 11.5% (95%CI, −12.6 to −10.6), and 12.7% (95%CI, −13.6 to −11.8), respectively. The decreases were noted across centers with high, mid, and low COVID-19 hospitalization burden, and also across high, mid, and low volume stroke/mechanical thrombectomy centers. High-volume COVID-19 centers (−20.5%) had greater declines in mechanical thrombectomy volumes than mid- (−10.1%) and low-volume (−8.7%) centers (p < 0.0001). There was a 1.5% stroke rate across 54,366 COVID-19 hospitalizations. SARS-CoV-2 infection was noted in 3.9% (784/20,250) of all stroke admissions. Conclusion: The COVID-19 pandemic was associated with a global decline in the volume of overall stroke hospitalizations, mechanical thrombectomy procedures, and intracranial hemorrhage admission volumes. Despite geographic variations, these volume reductions were observed regardless of COVID-19 hospitalization burden and pre-pandemic stroke/mechanical thrombectomy volumes. © 2021 World Stroke Organization.
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- 2021
34. Global Impact of COVID-19 on Stroke Care and IV Thrombolysis
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Nogueira, R.G. Qureshi, M.M. Abdalkader, M. Martins, S.O. Yamagami, H. Qiu, Z. Mansour, O.Y. Sathya, A. Czlonkowska, A. Tsivgoulis, G. Aguiar de Sousa, D. Demeestere, J. Mikulik, R. Vanacker, P. Siegler, J.E. Kõrv, J. Biller, J. Liang, C.W. Sangha, N.S. Zha, A.M. Czap, A.L. Holmstedt, C.A. Turan, T.N. Ntaios, G. Malhotra, K. Tayal, A. Loochtan, A. Ranta, A. Mistry, E.A. Alexandrov, A.W. Huang, D.Y. Yaghi, S. Raz, E. Sheth, S.A. Mohammaden, M.H. Frankel, M. Bila Lamou, E.G. Aref, H.M. Elbassiouny, A. Hassan, F. Menecie, T. Mustafa, W. Shokri, H.M. Roushdy, T. Sarfo, F.S. Alabi, T.O. Arabambi, B. Nwazor, E.O. Sunmonu, T.A. Wahab, K. Yaria, J. Mohammed, H.H. Adebayo, P.B. Riahi, A.D. Sassi, S.B. Gwaunza, L. Ngwende, G.W. Sahakyan, D. Rahman, A. Ai, Z. Bai, F. Duan, Z. Hao, Y. Huang, W. Li, G. Li, W. Liu, G. Luo, J. Shang, X. Sui, Y. Tian, L. Wen, H. Wu, B. Yan, Y. Yuan, Z. Zhang, H. Zhang, J. Zhao, W. Zi, W. Leung, T.W. Chugh, C. Huded, V. Menon, B. Pandian, J.D. Sylaja, P.N. Usman, F.S. Farhoudi, M. Hokmabadi, E.S. Horev, A. Reznik, A. Sivan Hoffmann, R. Ohara, N. Sakai, N. Watanabe, D. Yamamoto, R. Doijiri, R. Tokuda, N. Yamada, T. Terasaki, T. Yazawa, Y. Uwatoko, T. Dembo, T. Shimizu, H. Sugiura, Y. Miyashita, F. Fukuda, H. Miyake, K. Shimbo, J. Sugimura, Y. Yagita, Y. Takenobu, Y. Matsumaru, Y. Yamada, S. Kono, R. Kanamaru, T. Yamazaki, H. Sakaguchi, M. Todo, K. Yamamoto, N. Sonoda, K. Yoshida, T. Hashimoto, H. Nakahara, I. Kondybayeva, A. Faizullina, K. Kamenova, S. Zhanuzakov, M. Baek, J.-H. Hwang, Y. Lee, J.S. Lee, S.B. Moon, J. Park, H. Seo, J.H. Seo, K.-D. Sohn, S.I. Young, C.J. Ahdab, R. Wan Zaidi, W.A. Aziz, Z.A. Basri, H.B. Chung, L.W. Ibrahim, A.B. Ibrahim, K.A. Looi, I. Tan, W.Y. Yahya, N.W. Groppa, S. Leahu, P. Al Hashmi, A.M. Imam, Y.Z. Akhtar, N. Pineda-Franks, M.C. Co, C.O. Kandyba, D. Alhazzani, A. Al-Jehani, H. Tham, C.H. Mamauag, M.J. Venketasubramanian, N. Chen, C.-H. Tang, S.-C. Churojana, A. Akil, E. Aykaç, Ö. Ozdemir, A.O. Giray, S. Hussain, S.I. John, S. Le Vu, H. Tran, A.D. Nguyen, H.H. Nhu Pham, T. Nguyen, T.H. Nguyen, T.Q. Gattringer, T. Enzinger, C. Killer-Oberpfalzer, M. Bellante, F. De Blauwe, S. Vanhooren, G. De Raedt, S. Dusart, A. Lemmens, R. Ligot, N. Pierre Rutgers, M. Yperzeele, L. Alexiev, F. Sakelarova, T. Bedeković, M.R. Budincevic, H. Cindric, I. Hucika, Z. Ozretic, D. Saric, M.S. Pfeifer, F. Karpowic, I. Cernik, D. Sramek, M. Skoda, M. Hlavacova, H. Klecka, L. Koutny, M. Vaclavik, D. Skoda, O. Fiksa, J. Hanelova, K. Nevsimalova, M. Rezek, R. Prochazka, P. Krejstova, G. Neumann, J. Vachova, M. Brzezanski, H. Hlinovsky, D. Tenora, D. Jura, R. Jurák, L. Novak, J. Novak, A. Topinka, Z. Fibrich, P. Sobolova, H. Volny, O. Krarup Christensen, H. Drenck, N. Klingenberg Iversen, H. Simonsen, C.Z. Truelsen, T.C. Wienecke, T. Vibo, R. Gross-Paju, K. Toomsoo, T. Antsov, K. Caparros, F. Cordonnier, C. Dan, M. Faucheux, J.-M. Mechtouff, L. Eker, O. Lesaine, E. Ondze, B. Peres, R. Pico, F. Piotin, M. Pop, R. Rouanet, F. Gubeladze, T. Khinikadze, M. Lobjanidze, N. Tsiskaridze, A. Nagel, S. Ringleb, P.A. Rosenkranz, M. Schmidt, H. Sedghi, A. Siepmann, T. Szabo, K. Thomalla, G. Palaiodimou, L. Sagris, D. Kargiotis, O. Klivenyi, P. Szapary, L. Tarkanyi, G. Adami, A. Bandini, F. Calabresi, P. Frisullo, G. Renieri, L. Sangalli, D. Pirson, A. Uyttenboogaart, M. van den Wijngaard, I. Kristoffersen, E.S. Brola, W. Fudala, M. Horoch-Lyszczarek, E. Karlinski, M. Kazmierski, R. Kram, P. Rogoziewicz, M. Kaczorowski, R. Luchowski, P. Sienkiewicz-Jarosz, H. Sobolewski, P. Fryze, W. Wisniewska, A. Wiszniewska, M. Ferreira, P. Ferreira, P. Fonseca, L. Marto, J.P. Pinho E Melo, T. Nunes, A.P. Rodrigues, M. Tedim Cruz, V. Falup-Pecurariu, C. Krastev, G. Mako, M. de Leciñana, M.A. Arenillas, J.F. Ayo-Martin, O. Cruz Culebras, A. Tejedor, E.D. Montaner, J. Pérez-Sánchez, S. Tola Arribas, M.A. Rodriguez Vasquez, A. Mayza, M. Bernava, G. Brehm, A. Machi, P. Fischer, U. Gralla, J. Michel, P.L. Psychogios, M.-N. Strambo, D. Banerjee, S. Krishnan, K. Kwan, J. Butt, A. Catanese, L. Demchuk, A.M. Field, T. Haynes, J. Hill, M.D. Khosravani, H. Mackey, A. Pikula, A. Saposnik, G. Scott, C.A. Shoamanesh, A. Shuaib, A. Yip, S. Barboza, M.A. Barrientos, J.D. Portillo Rivera, L.I. Gongora-Rivera, F. Novarro-Escudero, N. Blanco, A. Abraham, M. Alsbrook, D. Altschul, D. Alvarado-Ortiz, A.J. Bach, I. Badruddin, A. Barazangi, N. Brereton, C. Castonguay, A. Chaturvedi, S. Chaudry, S.A. Choe, H. Choi, J.H. Dharmadhikari, S. Desai, K. Devlin, T.G. Doss, V.T. Edgell, R. Etherton, M. Farooqui, M. Frei, D. Gandhi, D. Grigoryan, M. Gupta, R. Hassan, A.E. Helenius, J. Kaliaev, A. Kaushal, R. Khandelwal, P. Khawaja, A.M. Khoury, N.N. Kim, B.S. Kleindorfer, D.O. Koyfman, F. Lee, V.H. Leung, L.Y. Linares, G. Linfante, I. Lutsep, H.L. Macdougall, L. Male, S. Malik, A.M. Masoud, H. McDermott, M. Mehta, B.P. Min, J. Mittal, M. Morris, J.G. Multani, S.S. Nahab, F. Nalleballe, K. Nguyen, C.B. Novakovic-White, R. Ortega-Gutierrez, S. Rahangdale, R.H. Ramakrishnan, P. Romero, J.R. Rost, N. Rothstein, A. Ruland, S. Shah, R. Sharma, M. Silver, B. Simmons, M. Singh, A. Starosciak, A.K. Strasser, S.L. Szeder, V. Teleb, M. Tsai, J.P. Voetsch, B. Balaguera, O. Pujol Lereis, V.A. Luraschi, A. Almeida, M.S. Cardoso, F.B. Conforto, A. De Deus Silva, L. Varrone Giacomini, L. Oliveira Lima, F. Longo, A.L. Magalhães, P.S.C. Martins, R.T. Mont'alverne, F. Mora Cuervo, D.L. Costa Rebello, L. Valler, L. Zetola, V.F. Lavados, P.M. Navia, V. Olavarría, V.V. Almeida Toro, J.M. Amaya, P.F.R. Bayona, H. Corredor, A. Rivera Ordonez, C.E. Mantilla Barbosa, D.K. Lara, O. Patiño, M.R. Diaz Escobar, L.F. Dejesus Melgarejo Fariña, D.E. Cardozo Villamayor, A. Zelaya Zarza, A.J. Barrientos Iman, D.M. Rodriguez Kadota, L. Campbell, B. Hankey, G.J. Hair, C. Kleinig, T. Ma, A. Tomazini Martins, R. Sahathevan, R. Thijs, V. Salazar, D. Yuan-Hao Wu, T. Haussen, D.C. Liebeskind, D. Yavagal, D.R. Jovin, T.G. Zaidat, O.O. Nguyen, T.N. SVIN COVID-19 Global Stroke Registry SVIN COVID-19 Global Stroke Registry
- Abstract
OBJECTIVE: To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods. METHODS: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases. RESULTS: There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95% confidence interval [CI] -11.7 to -11.3, p < 0.0001) decline. There were 13,334 IVT therapies in the 4 months preceding compared to 11,570 procedures during the pandemic, representing a 13.2% (95% CI -13.8 to -12.7, p < 0.0001) drop. Interfacility IVT transfers decreased from 1,337 to 1,178, or an 11.9% decrease (95% CI -13.7 to -10.3, p = 0.001). Recovery of stroke hospitalization volume (9.5%, 95% CI 9.2-9.8, p < 0.0001) was noted over the 2 later (May, June) vs the 2 earlier (March, April) pandemic months. There was a 1.48% stroke rate across 119,967 COVID-19 hospitalizations. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was noted in 3.3% (1,722/52,026) of all stroke admissions. CONCLUSIONS: The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID-19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months. © 2021 American Academy of Neurology.
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- 2021
35. Global impact of COVID-19 on stroke care
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Nogueira, RG, Abdalkader, M, Qureshi, MM, Frankel, MR, Mansour, OY, Yamagami, H, Qiu, Z, Farhoudi, M, Siegler, JE, Yaghi, S, Raz, E, Sakai, N, Ohara, N, Piotin, M, Mechtouff, L, Eker, O, Chalumeau, V, Kleinig, TJ, Pop, R, Liu, J, Winters, HS, Shang, X, Rodriguez Vasquez, A, Blasco, J, Arenillas, JF, Martinez-Galdamez, M, Brehm, A, Psychogios, M-N, Lylyk, P, Haussen, DC, Al-Bayati, AR, Mohammaden, MH, Fonseca, L, Luis Silva, M, Montalverne, F, Renieri, L, Mangiafico, S, Fischer, U, Gralla, J, Frei, D, Chugh, C, Mehta, BP, Nagel, S, Mohlenbruch, M, Ortega-Gutierrez, S, Farooqui, M, Hassan, AE, Taylor, A, Lapergue, B, Consoli, A, Campbell, BCV, Sharma, M, Walker, M, Van Horn, N, Fiehler, J, Huy, TN, Nguyen, QT, Watanabe, D, Zhang, H, Le, HV, Nguyen, VQ, Shah, R, Devlin, T, Khandelwal, P, Linfante, I, Izzath, W, Lavados, PM, Olavarria, VV, Silva, GS, de Carvalho Sousa, AV, Kirmani, J, Bendszus, M, Amano, T, Yamamoto, R, Doijiri, R, Tokuda, N, Yamada, T, Terasaki, T, Yazawa, Y, Morris, JG, Griffin, E, Thornton, J, Lavoie, P, Matouk, C, Hill, MD, Demchuk, AM, Killer-Oberpfalzer, M, Nahab, F, Altschul, D, Ramos-Pachon, A, Perez de la Ossa, N, Kikano, R, Boisseau, W, Walker, G, Cordina, SM, Puri, A, Kuhn, AL, Gandhi, D, Ramakrishnan, P, Novakovic-White, R, Chebl, A, Kargiotis, O, Czap, A, Zha, A, Masoud, HE, Lopez, C, Ozretic, D, Al-Mufti, F, Zie, W, Duan, Z, Yuan, Z, Huang, W, Hao, Y, Luo, J, Kalousek, V, Bourcier, R, Guile, R, Hetts, S, Al-Jehani, HM, AlHazzani, A, Sadeghi-Hokmabadi, E, Teleb, M, Payne, J, Lee, JS, Hong, JM, Sohn, S-I, Hwang, Y-H, Shin, DH, Roh, HG, Edgell, R, Khatri, R, Smith, A, Malik, A, Liebeskind, D, Herial, N, Jabbour, P, Magalhaes, P, Ozdemir, AO, Aykac, O, Uwatoko, T, Dembo, T, Shimizu, H, Sugiura, Y, Miyashita, F, Fukuda, H, Miyake, K, Shimbo, J, Sugimura, Y, Beer-Furlan, A, Joshi, K, Catanese, L, Abud, DG, Pontes Neto, O, Mehrpour, M, Al Hashmi, A, Saqqur, M, Mostafa, A, Fifi, JT, Hussain, S, John, S, Gupta, R, Sivan-Hoffmann, R, Reznik, A, Sani, AF, Geyik, S, Akil, ECR, Churojana, A, Ghoreishi, A, Saadatnia, M, Sharifipour, E, Ma, A, Faulder, K, Wu, T, Leung, L, Malek, A, Voetsch, B, Wakhloo, A, Rivera, R, Barrientos Iman, DM, Pikula, A, Lioutas, V-A, Thomalla, G, Birnbaum, L, Machi, P, Bernava, G, McDermott, M, Kleindorfer, D, Wong, K, Patterson, MS, Fiorot, JA, Huded, V, Mack, W, Tenser, M, Eskey, C, Multani, S, Kelly, M, Janardhan, V, Cornett, O, Singh, V, Murayama, Y, Mokin, M, Yang, P, Zhang, X, Yin, C, Han, H, Peng, Y, Chen, W, Crosa, R, Frudit, ME, Pandian, JD, Kulkarni, A, Yagita, Y, Takenobu, Y, Matsumaru, Y, Yamada, S, Kono, R, Kanamaru, T, Yamazaki, H, Sakaguchi, M, Todo, K, Yamamoto, N, Sonoda, K, Yoshida, T, Hashimoto, H, Nakahara, I, Cora, E, Volders, D, Ducroux, C, Shoamanesh, A, Ospel, J, Kaliaev, A, Ahmed, S, Rashid, U, Rebello, LC, Pereira, VM, Fahed, R, Chen, M, Sheth, SA, Palaiodimou, L, Tsivgoulis, G, Chandra, R, Koyfman, F, Leung, T, Khosravani, H, Dharmadhikari, S, Frisullo, G, Calabresi, P, Tsiskaridze, A, Lobjanidze, N, Grigoryan, M, Czlonkowska, A, de Sousa, DA, Demeestere, J, Liang, C, Sangha, N, Lutsep, HL, Ayo-Martin, O, Cruz-Culebras, A, Tran, AD, Young, CY, Cordonnier, C, Caparros, F, Alonso De Lecinana, M, Fuentes, B, Yavagal, D, Jovin, T, Spelle, L, Moret, J, Khatri, P, Zaidat, O, Raymond, J, Martins, S, Thanh, N, Nogueira, RG, Abdalkader, M, Qureshi, MM, Frankel, MR, Mansour, OY, Yamagami, H, Qiu, Z, Farhoudi, M, Siegler, JE, Yaghi, S, Raz, E, Sakai, N, Ohara, N, Piotin, M, Mechtouff, L, Eker, O, Chalumeau, V, Kleinig, TJ, Pop, R, Liu, J, Winters, HS, Shang, X, Rodriguez Vasquez, A, Blasco, J, Arenillas, JF, Martinez-Galdamez, M, Brehm, A, Psychogios, M-N, Lylyk, P, Haussen, DC, Al-Bayati, AR, Mohammaden, MH, Fonseca, L, Luis Silva, M, Montalverne, F, Renieri, L, Mangiafico, S, Fischer, U, Gralla, J, Frei, D, Chugh, C, Mehta, BP, Nagel, S, Mohlenbruch, M, Ortega-Gutierrez, S, Farooqui, M, Hassan, AE, Taylor, A, Lapergue, B, Consoli, A, Campbell, BCV, Sharma, M, Walker, M, Van Horn, N, Fiehler, J, Huy, TN, Nguyen, QT, Watanabe, D, Zhang, H, Le, HV, Nguyen, VQ, Shah, R, Devlin, T, Khandelwal, P, Linfante, I, Izzath, W, Lavados, PM, Olavarria, VV, Silva, GS, de Carvalho Sousa, AV, Kirmani, J, Bendszus, M, Amano, T, Yamamoto, R, Doijiri, R, Tokuda, N, Yamada, T, Terasaki, T, Yazawa, Y, Morris, JG, Griffin, E, Thornton, J, Lavoie, P, Matouk, C, Hill, MD, Demchuk, AM, Killer-Oberpfalzer, M, Nahab, F, Altschul, D, Ramos-Pachon, A, Perez de la Ossa, N, Kikano, R, Boisseau, W, Walker, G, Cordina, SM, Puri, A, Kuhn, AL, Gandhi, D, Ramakrishnan, P, Novakovic-White, R, Chebl, A, Kargiotis, O, Czap, A, Zha, A, Masoud, HE, Lopez, C, Ozretic, D, Al-Mufti, F, Zie, W, Duan, Z, Yuan, Z, Huang, W, Hao, Y, Luo, J, Kalousek, V, Bourcier, R, Guile, R, Hetts, S, Al-Jehani, HM, AlHazzani, A, Sadeghi-Hokmabadi, E, Teleb, M, Payne, J, Lee, JS, Hong, JM, Sohn, S-I, Hwang, Y-H, Shin, DH, Roh, HG, Edgell, R, Khatri, R, Smith, A, Malik, A, Liebeskind, D, Herial, N, Jabbour, P, Magalhaes, P, Ozdemir, AO, Aykac, O, Uwatoko, T, Dembo, T, Shimizu, H, Sugiura, Y, Miyashita, F, Fukuda, H, Miyake, K, Shimbo, J, Sugimura, Y, Beer-Furlan, A, Joshi, K, Catanese, L, Abud, DG, Pontes Neto, O, Mehrpour, M, Al Hashmi, A, Saqqur, M, Mostafa, A, Fifi, JT, Hussain, S, John, S, Gupta, R, Sivan-Hoffmann, R, Reznik, A, Sani, AF, Geyik, S, Akil, ECR, Churojana, A, Ghoreishi, A, Saadatnia, M, Sharifipour, E, Ma, A, Faulder, K, Wu, T, Leung, L, Malek, A, Voetsch, B, Wakhloo, A, Rivera, R, Barrientos Iman, DM, Pikula, A, Lioutas, V-A, Thomalla, G, Birnbaum, L, Machi, P, Bernava, G, McDermott, M, Kleindorfer, D, Wong, K, Patterson, MS, Fiorot, JA, Huded, V, Mack, W, Tenser, M, Eskey, C, Multani, S, Kelly, M, Janardhan, V, Cornett, O, Singh, V, Murayama, Y, Mokin, M, Yang, P, Zhang, X, Yin, C, Han, H, Peng, Y, Chen, W, Crosa, R, Frudit, ME, Pandian, JD, Kulkarni, A, Yagita, Y, Takenobu, Y, Matsumaru, Y, Yamada, S, Kono, R, Kanamaru, T, Yamazaki, H, Sakaguchi, M, Todo, K, Yamamoto, N, Sonoda, K, Yoshida, T, Hashimoto, H, Nakahara, I, Cora, E, Volders, D, Ducroux, C, Shoamanesh, A, Ospel, J, Kaliaev, A, Ahmed, S, Rashid, U, Rebello, LC, Pereira, VM, Fahed, R, Chen, M, Sheth, SA, Palaiodimou, L, Tsivgoulis, G, Chandra, R, Koyfman, F, Leung, T, Khosravani, H, Dharmadhikari, S, Frisullo, G, Calabresi, P, Tsiskaridze, A, Lobjanidze, N, Grigoryan, M, Czlonkowska, A, de Sousa, DA, Demeestere, J, Liang, C, Sangha, N, Lutsep, HL, Ayo-Martin, O, Cruz-Culebras, A, Tran, AD, Young, CY, Cordonnier, C, Caparros, F, Alonso De Lecinana, M, Fuentes, B, Yavagal, D, Jovin, T, Spelle, L, Moret, J, Khatri, P, Zaidat, O, Raymond, J, Martins, S, and Thanh, N
- Abstract
BACKGROUND: The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide. AIMS: We sought to measure the global impact of the COVID-19 pandemic on the volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at the height of the pandemic (1 March-31 May 2020) compared with two control three-month periods (immediately preceding and one year prior). METHODS: Retrospective, observational, international study, across 6 continents, 40 countries, and 187 comprehensive stroke centers. The diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases at participating centers. RESULTS: The hospitalization volumes for any stroke, intracranial hemorrhage, and mechanical thrombectomy were 26,699, 4002, and 5191 in the three months immediately before versus 21,576, 3540, and 4533 during the first three pandemic months, representing declines of 19.2% (95%CI, -19.7 to -18.7), 11.5% (95%CI, -12.6 to -10.6), and 12.7% (95%CI, -13.6 to -11.8), respectively. The decreases were noted across centers with high, mid, and low COVID-19 hospitalization burden, and also across high, mid, and low volume stroke/mechanical thrombectomy centers. High-volume COVID-19 centers (-20.5%) had greater declines in mechanical thrombectomy volumes than mid- (-10.1%) and low-volume (-8.7%) centers (p < 0.0001). There was a 1.5% stroke rate across 54,366 COVID-19 hospitalizations. SARS-CoV-2 infection was noted in 3.9% (784/20,250) of all stroke admissions. CONCLUSION: The COVID-19 pandemic was associated with a global decline in the volume of overall stroke hospitalizations, mechanical thrombectomy procedures, and intracranial hemorrhage admission volumes. Despite geographic variations, these volume reductions were observed regardless of COVID-19 hospitalization burden and pre-pandemic stroke/mechanical thrombectomy volumes.
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- 2021
36. Endovascular Treatment of Acute Stroke: Evolution and Selection of Techniques and Instruments Based on Thrombus Imaging
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Liebig, T., Gralla, J., Schroth, Gerhard, Liebig, T., Gralla, J., and Schroth, Gerhard
- Abstract
Mechanical thrombectomy provides higher recanalization rates than intravenous or intra-arterial thrombolysis. Finally this has been shown to translate into improved clinical outcome in six multicentric randomized controlled trials. However, within cohorts the clinical outcomes may vary, depending on the endovascular techniques applied. Systems aiming mainly for thrombus fragmentation and lacking a protection against distal embolization have shown disappointing results when compared to recent stent-retriever studies or even to historical data on local arterial fibrinolysis. Procedure-related embolic events are usually graded as adverse events in interventional neuroradiology. In stroke, however, the clinical consequences of secondary emboli have so far mostly been neglected and attributed to progression of the stroke itself. We summarize the evolution of instruments and techniques for endovascular, image-guided, microneurosurgical recanalization in acute stroke, and discuss how to avoid procedure-related embolic complications.
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- 2021
37. Excessive Contrast Medium Leakage in Hyperperfusion Syndrome
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Mordasini, P., Brekenfeld, C., Fung, C., Do, D. D., Schroth, G., and Gralla, J.
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- 2011
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38. Cerebral Microbleeds in Acute Ischemic Stroke: To Thrombolyse or Not?: 15
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El-Koussy, M., Gratz, P. P., Hsieh, K., von Arx, S., Mono, M.-L., Heldner, M. R., Fischer, U., Mattle, H. P., Arnold, M., Zubler, C., Schroth, G., Gralla, J., and Jung, S.
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- 2014
39. Impact of Renal Transplantation On Employment Opportunities in Young Adults.: Abstract# D2726
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Gralla, J., Murray, P., Harden, P., and Wiseman, A.
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- 2014
40. Timing and Persistence of Pre Transplant Donor Specific Antibodies (DSA) and Impact On Renal Allograft Outcomes.: Abstract# C1733
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Adebiyi, O., Gralla, J., Wiseman, A., Patrick, K., and Cooper, J.
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- 2014
41. Donor Specific Antibody (DSA) Formation in Tacrolimus-Based, Mycophenolate vs mTOR Immunosuppression Regimens.: Abstract# B977
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Mithani, Z., Adebiyi, O., Gralla, J., Klem, P., Cooper, J., and Wiseman, A.
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- 2014
42. Clinical Outcomes Based On Everolimus Concentrations in Combination With Tacrolimus and Prednisone in Renal Transplant Recipients.: Abstract# A193
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Kelly, N., Gralla, J., Lewis, V., Cooper, J., Adebiyi, O., Klem, P., and Wiseman, A.
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- 2014
43. Liver Transplant Candidates With Obesity and High MELD Are Not at Increased Risk for Post Transplant Death or Graft Failure.: Abstract# 2263
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Bambha, K., Dodge, J., Gralla, J., and Biggins, S.
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- 2014
44. Impact of Pre Transplant Donor Specific Antibodies in the Setting of a Negative Cell Based Flow Cytometry Cross Match On Graft Outcomes.: Abstract# 2220
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Adebiyi, O., Gralla, J., Wiseman, A., Patrick, K., and Cooper, J.
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- 2014
45. Predictive Value of the Strength and Class of Pre Transplant Donor Specific Antibodies (DSA) On Clinical Outcomes in Renal Allograft Recipients.: Abstract# 2217
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Adebiyi, O., Gralla, J., Wiseman, A., Klem, P., and Cooper, J.
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- 2014
46. Endovascular treatment of stroke patients with large pretreatment DWI lesions: EP3205
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Jung, S., Gilgen, M., Klimek, D., Gratz, P., Schroth, G., Gralla, J., Mordasini, P., Hsieh, K., Fischer, U., Arnold, M., Zubler, C., Mattle, H., and El-Koussy, M.
- Published
- 2014
47. Thrombolyse der Arteria cerebri media
- Author
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Brekenfeld, C., Gralla, J., Mattle, H.-P., El-Koussy, M., and Schroth, G.
- Published
- 2009
- Full Text
- View/download PDF
48. Quality of life in survivors after cervical artery dissection
- Author
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Fischer, U., Ledermann, I., Nedeltchev, K., Meier, N., Gralla, J., Sturzenegger, M., Mattle, H. P., and Arnold, M.
- Published
- 2009
- Full Text
- View/download PDF
49. Determinants and outcome of multiple and early recurrent cervical artery dissections
- Author
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Compter, A, Schilling, S, Vaineau, C, Goeggel-Simonetti, B, Metso, T, Southerland, A, Pezzini, A, Kloss, M, Touzé, E, Worrall, B, Thijs, V, Bejot, Y, Reiner, P, Grond-Ginsbach, C, Bersano, A, Brandt, T, Caso, V, Lyrer, P, Traenka, C, Lichy, C, Martin, J, Leys, D, Sarikaya, H, Baumgartner, R, Jung, S, Fischer, U, Engelter, S, Dallongeville, J, Chabriat, H, Tatlisumak, T, Bousser, M, Arnold, M, Debette, S, Abboud, S, Pandolfo, M, Bodenant, M, Louillet, F, Mas, J, Leder, S, Léger, A, Deltour, S, Crozier, S, Méresse, I, Canaple, S, Godefroy, O, Giroud, M, Decavel, P, Medeiros, E, Montiel, P, Moulin, T, Vuillier, F, Amouyel, P, Metso, A, Werner, I, Santos, M, Dichgans, M, Thomas-Feles, C, Weber, R, De Giuli, V, Caria, F, Poli, L, Padovani, A, Lanfranconi, S, Beretta, S, Ferrarese, C, Giacolone, G, Paolucci, S, Fluri, F, Hatz, F, Gisler, D, Bonati, L, Gensicke, H, Amort, M, Altintas, A, Markus, H, Majersik, J, Cole, J, Kittner, S, Buffon, F, Heldner, M, Mattle, H, Kurmann, R, Gralla, J, Compter, Annette, Schilling, Sabrina, Vaineau, Cloé Juliette, Goeggel-Simonetti, Barbara, Metso, Tiina M., Southerland, Andrew, Pezzini, Alessandro, Kloss, Manja, Touzé, Emmanuel, Worrall, Bradford B., Thijs, Vincent, Bejot, Yannick, Reiner, Peggy, Grond-Ginsbach, Caspar, Bersano, Anna, Brandt, Tobias, Caso, Valeria, Lyrer, Philippe A., Traenka, Christopher, Lichy, Christoph, Martin, Juan José, Leys, Didier, Sarikaya, Hakan, Baumgartner, Ralph W., Jung, Simon, Fischer, Urs, Engelter, Stefan T., Dallongeville, Jean, Chabriat, Hugues, Tatlisumak, Turgut, Bousser, Marie-Germaine, Arnold, Marcel, Debette, Stéphanie, Abboud S, Pandolfo M, Bodenant M, Louillet F, Mas JL, Leder S, Léger A, Deltour S, Crozier S, Méresse I, Canaple S, Godefroy O, Giroud M, Decavel P, Medeiros E, Montiel P, Moulin T, Vuillier F, Amouyel P, Metso AJ, Werner I, Arnold ML, Santos MD, Dichgans M, Thomas-Feles C, Weber R, De Giuli V, Caria F, Poli L, Padovani A, Lanfranconi S, Beretta S, Ferrarese C, Giacolone G, Paolucci S, Fluri F, Hatz F, Gisler D, Bonati L, Gensicke H, Amort M, Altintas A, Markus H, Majersik J, Cole J, Kittner S, Buffon F, Heldner MR, Mattle HP, Kurmann R, Gralla J., Compter, A, Schilling, S, Vaineau, C, Goeggel-Simonetti, B, Metso, T, Southerland, A, Pezzini, A, Kloss, M, Touzé, E, Worrall, B, Thijs, V, Bejot, Y, Reiner, P, Grond-Ginsbach, C, Bersano, A, Brandt, T, Caso, V, Lyrer, P, Traenka, C, Lichy, C, Martin, J, Leys, D, Sarikaya, H, Baumgartner, R, Jung, S, Fischer, U, Engelter, S, Dallongeville, J, Chabriat, H, Tatlisumak, T, Bousser, M, Arnold, M, Debette, S, Abboud, S, Pandolfo, M, Bodenant, M, Louillet, F, Mas, J, Leder, S, Léger, A, Deltour, S, Crozier, S, Méresse, I, Canaple, S, Godefroy, O, Giroud, M, Decavel, P, Medeiros, E, Montiel, P, Moulin, T, Vuillier, F, Amouyel, P, Metso, A, Werner, I, Santos, M, Dichgans, M, Thomas-Feles, C, Weber, R, De Giuli, V, Caria, F, Poli, L, Padovani, A, Lanfranconi, S, Beretta, S, Ferrarese, C, Giacolone, G, Paolucci, S, Fluri, F, Hatz, F, Gisler, D, Bonati, L, Gensicke, H, Amort, M, Altintas, A, Markus, H, Majersik, J, Cole, J, Kittner, S, Buffon, F, Heldner, M, Mattle, H, Kurmann, R, Gralla, J, Compter, Annette, Schilling, Sabrina, Vaineau, Cloé Juliette, Goeggel-Simonetti, Barbara, Metso, Tiina M., Southerland, Andrew, Pezzini, Alessandro, Kloss, Manja, Touzé, Emmanuel, Worrall, Bradford B., Thijs, Vincent, Bejot, Yannick, Reiner, Peggy, Grond-Ginsbach, Caspar, Bersano, Anna, Brandt, Tobias, Caso, Valeria, Lyrer, Philippe A., Traenka, Christopher, Lichy, Christoph, Martin, Juan José, Leys, Didier, Sarikaya, Hakan, Baumgartner, Ralph W., Jung, Simon, Fischer, Urs, Engelter, Stefan T., Dallongeville, Jean, Chabriat, Hugues, Tatlisumak, Turgut, Bousser, Marie-Germaine, Arnold, Marcel, Debette, Stéphanie, Abboud S, Pandolfo M, Bodenant M, Louillet F, Mas JL, Leder S, Léger A, Deltour S, Crozier S, Méresse I, Canaple S, Godefroy O, Giroud M, Decavel P, Medeiros E, Montiel P, Moulin T, Vuillier F, Amouyel P, Metso AJ, Werner I, Arnold ML, Santos MD, Dichgans M, Thomas-Feles C, Weber R, De Giuli V, Caria F, Poli L, Padovani A, Lanfranconi S, Beretta S, Ferrarese C, Giacolone G, Paolucci S, Fluri F, Hatz F, Gisler D, Bonati L, Gensicke H, Amort M, Altintas A, Markus H, Majersik J, Cole J, Kittner S, Buffon F, Heldner MR, Mattle HP, Kurmann R, and Gralla J.
- Abstract
Objective To assess putative risk factors and outcome of multiple and early recurrent cervical artery dissection (CeAD). Methods We combined data from 2 multicenter cohorts and compared patients with multiple CeAD at initial diagnosis, early recurrent CeAD within 3 to 6 months, and single nonrecurrent CeAD. Putative risk factors, clinical characteristics, functional outcome, and risk of recurrent ischemic events were assessed. Results Of 1,958 patients with CeAD (mean ± SD age 44.3 ± 10 years, 43.9% women), 1,588 (81.1%) had single nonrecurrent CeAD, 340 (17.4%) hadmultiple CeAD, and 30 (1.5%) presented with single CeAD at admission and had early recurrent CeAD. Patients with multiple or early recurrent CeAD did not significantly differ with respect to putative risk factors, clinical presentation, and outcome. In multivariable analyses, patients with multiple or early recurrent CeAD more often had recent infection (odds ratio [OR] 1.81, 95% confidence interval [CI] 1.29-2.53), vertebral artery dissection (OR 1.82, 95% CI 1.34-2.46), family history of stroke (OR 1.55, 95% CI 1.06-2.25), cervical pain (OR 1.36, 95% CI 1.01-1.84), and subarachnoid hemorrhage (OR 2.85, 95% CI 1.01-8.04) at initial presentation compared to patients with single nonrecurrent CeAD. Patients withmultiple or early recurrent CeAD also had a higher incidence of cerebral ischemia (hazard ratio 2.77, 95% CI 1.49-5.14) at 3 to 6 months but no difference in functional outcome compared to patients with single nonrecurrent CeAD. Conclusion Patients with multiple and early recurrent CeAD share similar risk factors, clinical characteristics, and functional outcome. Compared to patients with single nonrecurrent CeAD, they are more likely to have recurrent cerebral ischemia at 3 to 6 months, possibly reflecting an underlying transient vasculopathy.
- Published
- 2018
50. Brachial Plexus Birth Injury: An Epidemiological State Level Analysis of Trends and Risk Factors
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Sibbel, S, Lalka, A, and Gralla, J
- Subjects
brachial plexus birth injury ,ddc: 610 ,pediatrics ,epidemiology ,shoulder dystocia ,610 Medical sciences ,Medicine ,birth trauma - Abstract
Objectives/Interrogation: Brachial plexus birth injury is a condition in which the brachial plexus is thought to be damaged during the birth process. Studies have cited a varying incidence rate ranging from 0.5 to 4.0/1000 live births. The purpose of this study is to evaluate birth claims [for full text, please go to the a.m. URL], 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
- Published
- 2020
- Full Text
- View/download PDF
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