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8 results on '"Graindorge E"'

1. Development of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors

Author

Francotte, Pierre, primary, Goffin, Eric, additional, Fraikin, Pierre, additional, Graindorge, E., additional, Lestage, Pierre, additional, Danober, Laurence, additional, Challal, Sylvie, additional, Rogez, Nathalie, additional, Nosjean, Olivier, additional, Caignard, Daniel-Henri, additional, Pirotte, Bernard, additional, and de Tullio, Pascal, additional

Published
2013
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5. Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors.

Author

Francotte P, Tullio Pd, Goffin E, Dintilhac G, Graindorge E, Fraikin P, Lestage P, Danober L, Thomas JY, Caignard DH, and Pirotte B

Subjects
Allosteric Regulation, Animals, Benzothiadiazines, Cognition drug effects, Cyclic S-Oxides chemistry, Cyclic S-Oxides pharmacology, Drug Design, Electric Stimulation, Excitatory Postsynaptic Potentials, Hippocampus drug effects, Hippocampus physiology, In Vitro Techniques, Norepinephrine metabolism, Oocytes drug effects, Oocytes physiology, RNA, Messenger genetics, RNA, Messenger metabolism, Rats, Rats, Wistar, Receptors, AMPA genetics, Recognition, Psychology drug effects, Structure-Activity Relationship, Thiadiazines chemistry, Thiadiazines pharmacology, Xenopus, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid pharmacology, Cyclic S-Oxides chemical synthesis, Receptors, AMPA metabolism, Thiadiazines chemical synthesis
Abstract

A series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides have been synthesized and evaluated as potentiators of AMPA receptors. Attention was paid to the impact of the substituent introduced at the 7-position of the heterocycle. The biological evaluation was achieved by measuring the AMPA current in rat cortex mRNA-injected Xenopus oocytes. The most potent compound, 4-ethyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (12a) was found to be active in an object recognition test in rats demonstrating cognition enhancing effects in vivo after oral administration.

Published
2007
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6. [Anatomy of the cranio-mandibular bones].

Author

Graindorge E

Subjects
Humans, Occipital Bone anatomy & histology, Sphenoid Bone anatomy & histology, Temporal Bone anatomy & histology, Mandible anatomy & histology, Skull anatomy & histology
Published
1978

8. [Therapeutic indications for premolar extraction].

Author

Thilloy G, Van Besien Y, Papernot G, Delachapelle C, Blocquel H, Doual A, Graindorge E, and Lainey P

Subjects
Alveolar Process pathology, Humans, Malocclusion pathology, Bicuspid surgery, Malocclusion therapy, Serial Extraction
Published
1975

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