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Your search keyword '"Graham-Gurysh, Elizabeth G."' showing total 12 results
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12 results on '"Graham-Gurysh, Elizabeth G."'

1. Contributors

Author

Ainslie, Kristy M., primary, Al-Dossary, Amal A., additional, Al-Jamal, Khuloud T., additional, Amiji, Mansoor M., additional, Bachelder, Eric M., additional, Dhadwar, Baljevan, additional, Basireddy, Shreya, additional, Batra, Surinder K., additional, Beck, Wolfgang A., additional, Ben-Akiva, Elana, additional, Carpenter, Brandon W., additional, Castro, Flávia, additional, Chen, Guiyuan, additional, Dalal, Vipin, additional, Peer, Dan, additional, Doran, Peter, additional, Gautam, Shailendra K., additional, Graham-Gurysh, Elizabeth G., additional, Green, Jordan J., additional, Hay, Ian, additional, Nutter Howard, Faith Hannah, additional, Huang, Di, additional, Iscaro, Alessandra, additional, Jain, Maneesh, additional, Karlsson, Johan, additional, Katoh, Hiroshi, additional, Kim, Dongyoon, additional, Kulkarni, Ashish A., additional, Kwon, Soonbum, additional, Lang, Tianqun, additional, Li, Jiahe, additional, Li, Jiawei, additional, Li, Yamin, additional, Li, Yaping, additional, Liu, Zhaoji, additional, Lu, Xin, additional, Matosevic, Sandro, additional, Milane, Lara, additional, Min, Yuanzeng, additional, Muthana, Munitta, additional, Oh, Yu-Kyoung, additional, Padmakumar, Smrithi, additional, Parayath, Neha, additional, Rahmy, Sharif, additional, Ramesh, Anujan, additional, Sarmento, Bruno, additional, Scott, Myria, additional, Stephens, Elisa, additional, Stotsky, Lior, additional, Su, Lanhong, additional, Sun, Xin, additional, Tarab, Dana, additional, Tzeng, Stephany Y., additional, Varma, Devika M., additional, Vincent, Benjamin G., additional, Walters, Adam A., additional, Wang, Andrew Z., additional, Wu, Yina, additional, Wu, Yuqianxun, additional, Xu, Qiaobing, additional, Yeo, Yoon, additional, Yin, Qi, additional, Yu, Hongzhe, additional, Zhang, Yong, additional, and Zhu, Runqi, additional

Published
2022
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5. Development of an Intranasal Gel for the Delivery of a Broadly Acting Subunit Influenza Vaccine

Author

Varma, Devika M., primary, Batty, Cole J., additional, Stiepel, Rebeca T., additional, Graham-Gurysh, Elizabeth G., additional, Roque, John A., additional, Pena, Erik S., additional, Hasan Zahid, M. Shamim, additional, Qiu, Kunyu, additional, Anselmo, Aaron, additional, Hill, David B., additional, Ross, Ted M., additional, Bachelder, Eric M., additional, and Ainslie, Kristy M., additional

Published
2022
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11. In Vivo and Cellular Trafficking of Acetalated Dextran Microparticles for Delivery of a Host-Directed Therapy for Salmonella enterica Serovar Typhi Infection

Author

Johnson, Monica M., primary, Collier, Michael A., additional, Hoang, Ky V., additional, Pino, Erica N., additional, Graham-Gurysh, Elizabeth G., additional, Gallovic, Matthew D., additional, Zahid, Md. Shamim Hasan, additional, Chen, Naihan, additional, Schlesinger, Larry, additional, Gunn, John S., additional, Bachelder, Eric M., additional, and Ainslie, Kristy M., additional

Published
2018
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12. In Vivo and Cellular Trafficking of Acetalated Dextran Microparticles for Delivery of a Host-Directed Therapy for Salmonella entericaSerovar Typhi Infection

Author

Johnson, Monica M., Collier, Michael A., Hoang, Ky V., Pino, Erica N., Graham-Gurysh, Elizabeth G., Gallovic, Matthew D., Zahid, Md. Shamim Hasan, Chen, Naihan, Schlesinger, Larry, Gunn, John S., Bachelder, Eric M., and Ainslie, Kristy M.

Abstract

Previously we have encapsulated host-directed therapy AR-12 into acetalated dextran (Ace-DEX) microparticles (MPs) to mitigate drug toxicity and passively target phagocytic host cells. Herein, we have improved upon our initial emulsion-based formulation of Ace-DEX MPs encapsulating AR-12 (AR-12/MPs) by improving the drug encapsulation efficiency, evaluating sterilization processes for manufacturing, and understanding cellular and in vivo trafficking of the MPs. By using an alternative solvent system, ethyl acetate, we report an increased encapsulation efficiency of AR-12 while maintaining the pH-responsive degradation kinetics of Ace-DEX MPs. To better manufacture this novel antimicrobial formulation, we sterilized AR-12/MPs by gamma irradiation or ethylene oxide and evaluated their efficacy against intracellular Salmonella entericaserovar Typhi. Sterilized AR-12/MPs resulted in a significant reduction in intracellular bacterial burden compared to Blank/MPs. We also characterized intracellular trafficking of Ace-DEX MPs encapsulating fluorophores, which demonstrated internalization of MPs in endo/lysosomal compartments and time and degradation-rate dependent lysosomal escape into cytosolic compartments. Additionally, in vivo toxicity was mitigated following encapsulation of AR-12, where the maximum tolerated dose of AR-12 was increased compared to soluble treatment via intranasal, intravenous, and intraperitoneal administration routes. Following in vivo trafficking of Ace-DEX MPs via the same routes, intranasal administration demonstrated the highest accumulation in the lungs, liver, and kidneys, which persisted out to 240 h. Overall, we have advanced the formulation of this host-directed therapy and broadened the understanding of Ace-DEX MP delivery.

Published
2018
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