1. Convergent changes in muscle metabolism depend on duration of high-altitude ancestry across Andean waterfowl
- Author
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Neal J Dawson, Luis Alza, Gabriele Nandal, Graham R Scott, and Kevin G McCracken
- Subjects
birds ,high-altitude adaptation ,hypoxia ,energy metabolism ,myoglobin ,muscle energetics ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
High-altitude environments require that animals meet the metabolic O2 demands for locomotion and thermogenesis in O2-thin air, but the degree to which convergent metabolic changes have arisen across independent high-altitude lineages or the speed at which such changes arise is unclear. We examined seven high-altitude waterfowl that have inhabited the Andes (3812–4806 m elevation) over varying evolutionary time scales, to elucidate changes in biochemical pathways of energy metabolism in flight muscle relative to low-altitude sister taxa. Convergent changes across high-altitude taxa included increased hydroxyacyl-coA dehydrogenase and succinate dehydrogenase activities, decreased lactate dehydrogenase, pyruvate kinase, creatine kinase, and cytochrome c oxidase activities, and increased myoglobin content. ATP synthase activity increased in only the longest established high-altitude taxa, whereas hexokinase activity increased in only newly established taxa. Therefore, changes in pathways of lipid oxidation, glycolysis, and mitochondrial oxidative phosphorylation are common strategies to cope with high-altitude hypoxia, but some changes require longer evolutionary time to arise.
- Published
- 2020
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