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273 results on '"Graham, Victoria A."'

1. Convalescent human plasma candidate reference materials protect against Crimean-Congo haemorrhagic fever virus (CCHFV) challenge in an A129 mouse model

Author

Kempster, Sarah, Hassall, Mark, Graham, Victoria, Kennedy, Emma, Findlay-Wilson, Stephen, Salguero, Francisco J., Bagci, Binnur, Elaldi, Nazif, Oz, Murtaza, Tasseten, Tuba, Charlton, Frank W., Barr, John N., Fontana, Juan, Duru, Chinwe, Ezeajughi, Ernest, Matejtschuk, Paul, Arnold, Ulrike, Adedeji, Yemisi, Mirazimi, Ali, Hewson, Roger, Dowall, Stuart, and Almond, Neil

Published
2024
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2. Publisher Correction: Refinement of an ovine-based immunoglobulin therapy against SARS-CoV-2, with comparison of whole IgG versus F(ab′)2 fragments

Author

Findlay‑Wilson, Stephen, Easterbrook, Linda, Smith, Sandra, Pope, Neville, Aldridge, Matthew, Humphries, Gareth, Schuhmann, Holger, Ngabo, Didier, Rayner, Emma, Otter, Ashley, Coleman, Thomas, Hicks, Bethany, Halkerston, Rachel, Apostolakis, Kostis, Taylor, Stephen, Fotheringham, Susan, Horton, Amanda, CanoCejas, Irene, Wand, Matthew, Tree, Julia A., Sutton, Mark, Graham, Victoria, Hewson, Roger, and Dowall, Stuart

Published
2023
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3. Refinement of an ovine-based immunoglobulin therapy against SARS-CoV-2, with comparison of whole IgG versus F(ab′)2 fragments

Author

Findlay-Wilson, Stephen, Easterbrook, Linda, Smith, Sandra, Pope, Neville, Aldridge, Matthew, Humphries, Gareth, Schuhmann, Holger, Ngabo, Didier, Rayner, Emma, Otter, Ashley, Coleman, Thomas, Hicks, Bethany, Halkerston, Rachel, Apostolakis, Kostis, Taylor, Stephen, Fotheringham, Susan, Horton, Amanda, CanoCejas, Irene, Wand, Matthew, Tree, Julia A., Sutton, Mark, Graham, Victoria, Hewson, Roger, and Dowall, Stuart

Published
2023
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5. Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial

Author

Munro, Alasdair P S, Feng, Shuo, Janani, Leila, Cornelius, Victoria, Aley, Parvinder K, Babbage, Gavin, Baxter, David, Bula, Marcin, Cathie, Katrina, Chatterjee, Krishna, Dodd, Kate, Enever, Yvanne, Qureshi, Ehsaan, Goodman, Anna L, Green, Christopher A, Harndahl, Linda, Haughney, John, Hicks, Alexander, van der Klaauw, Agatha A, Kanji, Nasir, Libri, Vincenzo, Llewelyn, Martin J, McGregor, Alastair C, Minassian, Angela M, Moore, Patrick, Mughal, Mehmood, Mujadidi, Yama F, Holliday, Kyra, Osanlou, Orod, Osanlou, Rostam, Owens, Daniel R, Pacurar, Mihaela, Palfreeman, Adrian, Pan, Daniel, Rampling, Tommy, Regan, Karen, Saich, Stephen, Bawa, Tanveer, Saralaya, Dinesh, Sharma, Sunil, Sheridan, Ray, Maallah, Mina, Thomson, Emma C, Todd, Shirley, Twelves, Chris, Read, Robert C, Charlton, Sue, Hallis, Bassam, Ramsay, Mary, Andrews, Nick, Lambe, Teresa, Nguyen-Van-Tam, Jonathan S, Snape, Matthew D, Liu, Xinxue, Faust, Saul N, Riordan, Andrew, Ustianowski, Andrew, Rogers, Chris, Katechia, Kashyap, Cooper, Alison, Freedman, Andrew, Hughes, Rachel, Grundy, Lynne, Tudor Jones, Lona, Harrison, Elizabeth, Snashall, Emma, Mallon, Lewis, Burton, Katharine, Storton, Kim, Munusamy, Malathi, Tandy, Bridget, Egbo, Akamino, Cox, Stephen, Ahmed, Nabeela Nazir, Shenoy, Anil, Bousfield, Rachel, Wixted, Donna, Gutteridge, Helen, Mansfield, Becky, Herbert, Christopher, Murira, Jennifer, Calderwood, James, Barker, Dominique, Brandon, Jacqueline, Tulloch, Hayley, Colquhoun, Suzie, Thorp, Helen, Radford, Helen, Evans, Julie, Baker, Helena, Thorpe, Jeanette, Batham, Sally, Hailstone, Jessica, Phillips, Rachael, Kumar, Dileep, Westwell, Fran, Sturdy, Ann, Barcella, Lara, Soussi, Najwa, Mpelembue, Mushiya, Raj, Sreena, Sharma, Rajni, Corrah, Tumena, John, Laurence, Whittington, Ashley, Roche, Siobhan, Wagstaff, Lynda, Farrier, Adam, Bisnauthsing, Karen, Abeywickrama, Movin, Spence, Niamh, Packham, Alice, Serafimova, Teona, Aslam, Suahil, McGreevy, Caitlin, Borca, Alessandro, DeLosSantosDominguez, Pamela, Palmer, Emily, Broadhead, Samantha, Farooqi, Sadaf, Piper, Jo, Weighell, Rowena, Pickup, Lorinda, Shamtally, Djamila, Domingo, Jason, Kourampa, Evgenia, Hale, Colin, Gibney, Jennifer, Stackpoole, Michael, Rashid-Gardner, Zalina, Lyon, Rebecca, McDonnell, Chloe, Cole, Christine, Stewart, Anna, McMillan, Gillian, Savage, Mary, Beckett, Helen, Moorbey, Chantelle, Desai, Amisha, Brown, Claire, Naker, Kush, Gokani, Karishma, Trinham, Charlotte, Sabine, Charlette, Moore, Sophie, Hurdover, Steve, Justice, Edwin, Stone, Megan, Plested, Emma, Ferreira Da Silva, Carla, White, Rachel, Robinson, Hannah, Turnbull, Iain, Morshead, Gertraud, Drake-Brockman, Rachael, Smith, Catherine, Li, Grace, Kasanyinga, Mwila, Clutterbuck, Elizabeth A, Bibi, Sagida, Singh, Michael, Champaneri, Trishna, Irwin, Margaret, Khan, Mohammed, Kownacka, Alicia, Nabunjo, Martha, Osuji, Carol, Hladkiwskyj, John, Galvin, Dominic, Patel, Gita, Grierson, Jacques, Males, Samantha, Askoolam, Krishna, Barry, Joshua, Mouland, Johanna, Longhurst, Beverley, Moon, Maria, Giddins, Beth, Pereira Dias Alves, Carlota, Richmond, Leah, Minnis, Christine, Baryschpolec, Sonia, Elliott, Scott, Fox, Lauren, Graham, Victoria, Baker, Natalie, Godwin, Kerry, Buttigieg, Karen, Knight, Chanice, Brown, Phillip, Lall, Paminder, Shaik, Imam, Chiplin, Emily, Brunt, Emily, Leung, Stephanie, Allen, Lauren, Thomas, Steve, Fraser, Sara, Choi, Bea, Gouriet, Jade, Perkins, Jonathan, Gowland, Andrew, Macdonald, Jonathan, Seenan, John Paul, Starinskij, Igor, Seaton, Andrew, Peters, Erica, Singh, Stephen, Gardside, Ben, Bonnaud, Avril, Davies, Ceri, Gordon, Elizabeth, Keenan, Samantha, Hall, Jane, Wilkins, Suzanne, Tasker, Suzanne, James, Rob, Seath, Ingrid, Littlewood, Kelly, Newman, Joseph, Boubriak, Iryna, Suggitt, Debbie, Haydock, Helen, Bennett, Sara, Woodyatt, Wiesia, Hughes, Kerry, Bell, Judith, Coughlan, Tricia, van Welsenes, Donald, Kamal, Mohammed, Cooper, Chris, Tunstall, Simon, Ronan, Nicholas, Cutts, Rebecca, Dare, Tracey, Yim, Yee Ting Nicole, Whittley, Sarah, Hamal, Shama, Ricamara, Marivic, Adams, Kirsty, Baker, Holly, Driver, Kimberley, Turner, Nicola, Rawlins, Todd, Roy, Subarna, Merida-Morillas, Marta, Sakagami, Yukari, Andrews, Antonette, Goncalvescordeiro, Lillian, Stokes, Matthew, Ambihapathy, Wythehi, Spencer, Joanne, Parungao, Nina, Berry, Lisa, Cullinane, James, Presland, Laura, Ross Russell, Amy, Warren, Sarah, Baker, Jonathan, Oliver, Abigail, Buadi, Amanda, Lee, Kim, Haskell, Louise, Romani, Rossana, Bentley, Ian, Whitbred, Tim, Fowler, Simon, Gavin, John, Magee, Alan, Watson, Tara, Nightingale, Kari, Marius, Phedra, Summerton, Eloise, Locke, Emily, Honey, Thomas, Lingwood, Aidan, de la Haye, Anastasia, Elliott, Ryan Stephen, Underwood, Karen, King, Mikayala, Davies-Dear, Sharon, Horsfall, Emily, Chalwin, Olivia, Burton, Holly, Edwards, Christopher J, Welham, Benjamin, Appleby, Kim, Dineen, Emily, Garrahy, Sarah, Hall, Fran, Ladikou, Eleni, Mullan, Dee, Hansen, Daniel, Campbell, Marion, Dos Santos, Filipa, Lakeman, Nicki, Branney, Debbie, Vamplew, Luke, Hogan, Alison, Frankham, Jorden, Wiselka, Martin, Vail, Denny, Wenn, Victoria, Renals, Valerie, Ellis, Kate, Lewis-Taylor, Jessica, Habash-Bailey, Haniah, Magan, Javier, and Hardy, Anna

Published
2022
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6. Comparison of Chikungunya Virus-Induced Disease Progression and Pathogenesis in Type-I Interferon Receptor-Deficient Mice (A129) and Two Wild-Type (129Sv/Ev and C57BL/6) Mouse Strains.

Author

Graham, Victoria A., Easterbrook, Linda, Rayner, Emma, Findlay-Wilson, Stephen, Flett, Lucy, Kennedy, Emma, Fotheringham, Susan, Kempster, Sarah, Almond, Neil, and Dowall, Stuart

Abstract

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus causing a debilitating febrile illness with rheumatic disease symptoms of arthralgia and arthritis. Since its spread outside of Africa in 2005, it continues to cause outbreaks and disseminates into new territories. Intervention strategies are urgently required, including vaccination and antiviral approaches. To test efficacy, the use of small animal models is required. Two mouse strains, A129, with a deficiency in their type-I interferon (IFN) receptor, and C57BL/6 are widely used. A direct comparison of these strains alongside the wild-type parental strain of the A129 mice, 129Sv/Ev, was undertaken to assess clinical disease progression, viral loads in key tissues, histological changes and levels of sera biomarkers. Our results confirm the severe disease course in A129 mice which was not observed in the parental 129Sv/Ev strain. Of the two wild-type strains, viral loads were higher in 129Sv/Ev mice compared to C57BL/6 counterparts. Our results have established these models and parameters for the future testing of vaccines and antiviral approaches. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial

Author

Riordan, Andrew, Ustianowski, Andrew, Rogers, Chris A, Hughes, Stephen, Longshaw, Laura, Stockport, Jane, Hughes, Rachel, Grundy, Lynne, Tudor Jones, Lona, Guha, Arpan, Snashall, Emma, Eadsforth, Tom, Reeder, Sally, Storton, Kim, Munusamy, Malathi, Tandy, Bridget, Egbo, Akamino, Cox, Stephen, Ahmed, Nabeela Nazir, Shenoy, Anil, Bousfield, Rachel, Wixted, Donna, Gutteridge, Helen, Mansfield, Becky, Herbert, Christopher, Holliday, Kyra, Calderwood, James, Barker, Dominique, Brandon, Jacqueline, Tulloch, Hayley, Colquhoun, Suzie, Thorp, Helen, Radford, Helen, Evans, Julie, Baker, Helena, Thorpe, Jeanette, Batham, Sally, Hailstone, Jessica, Phillips, Rachael, Kumar, Dileep, Westwell, Fran, Makia, Fiona, Hopkins, NinaSimone, Barcella, Lara, Mpelembue, Mushiya, dabagh, Maja, lang, Matilda, khan, Farida, Adebambo, Olumide, Chita, Sunder, Corrah, Tumena, Whittington, Ashley, John, Laurence, Roche, Siobhan, Wagstaff, Lynda, Farrier, Adam, Bisnauthsing, Karen, Serafimova, Teona, Nanino, Elisa, Cooney, Enya, Wilson-Goldsmith, Jaimie, Nguyen, Hanna, Mazzella, Andrea, Jackson, Beth, Aslam, Suahil, Bawa, Tanveer, Broadhead, Samantha, Farooqi, Sadaf, Piper, Jo, Weighell, Rowena, Pickup, Lorinda, Shamtally, Djamila, Domingo, Jason, Kourampa, Evgenia, Hale, Colin, Gibney, Jennifer, Stackpoole, Michael, Rashid-Gardner, Zalina, Lyon, Rebecca, McDonnell, Chloe, Cole, Christine, Stewart, Anna, McMillan, Gillian, Savage, Mary, Beckett, Helen, Moorbey, Chantelle, Desai, Amisha, Brown, Claire, Naker, Kush, Qureshi, Ehsaan, Trinham, Charlotte, Sabine, Charlotte, Moore, Sophie, Hurdover, Steve, Justice, Edwin, Smith, David, Plested, Emma, Ferreira Da Silva, Carla, White, Rachel, Robinson, Hannah, Cifuentes, Liliana, Morshead, Gertraud, Drake-Brockman, Rachael, Kinch, Patrick, Kasanyinga, Mwila, Clutterbuck, Elizabeth A., Bibi, Sagida, Stuart, Arabella SV, Shaw, Robert H, Singh, Michael, Champaneri, Trishna, Irwin, Margaret, Khan, Mohammed, Kownacka, Alicja, Nabunjo, Martha, Osuji, Carool, Hladkiwskyj, John, Galvin, Dominic, Patel, Gita, Mouland, Johanna, Longhurst, Beverley, Moon, Maria, Giddins, Beth, Pereira Dias Alves, Carlota, Richmond, Leah, Minnis, Christine, Baryschpolec, Sonia, Elliott, Scott, Fox, Lauren, Graham, Victoria, Baker, Natalie, Godwin, Kerry, Buttigieg, Karren, Knight, Chanice, Brown, Phillip, Lall, Paminder, Shaik, Imam, Chiplin, Emily, Brunt, Emily, Leung, Stephanie, Allen, Lauren, Thomas, Steve, Fraser, Sara, Choi, Bea, Gouriet, Jade, Freedman, Andrew, Perkins, Jonathan, Gowland, Andrew, Macdonald, Jonathan, Seenan, John Paul, Starinskij, Igor, Seaton, Andrew, Peters, Erica, Singh, Stephen, Gardside, Ben, Bonnaud, Avril, Davies, Ceri, Gordon, Elizabeth, Keenan, Samantha, Hall, Jane, Wilkins, Suzanne, Tasker, Suzanne, James, Rob, Seath, Ingrid, Littlewood, Kelly, Newman, Joseph, Boubriak, Iryna, Suggitt, Debbie, Haydock, Helen, Bennett, Sara, Woodyatt, Wiesia, Hughes, Kerry, Bell, Judith, Coughlan, Tricia, van Welsenes, Donald, Kamal, Mohammed, Cooper, Chris, Tunstall, Simon, Ronan, Nicholas, Cutts, Rebecca, Dare, Tracey, Yim, Yee Ting Nicole, Whittley, Sarah, Ricamara, Marivic, Hamal, Shama, Adams, Kirsty, Baker, Holly, Driver, Kimberley, Turner, Nicola, Rawlins, Todd, Roy, Subarna, Merida-Morillas, Marta, Sakagami, Yukari, Andrews, Antonette, Goncalves cordeiro, Lillian, Stokes, Matthew, Ambihapathy, Wythehi, Spencer, Joanne, Parungao, Nina, Berry, Lisa, Cullinane, James, Presland, Laura, Ross-Russell, Amy, Warren, Sarah, Baker, Jonathan, Oliver, Abigail, Buadi, Amanda, Lee, Kim, Haskell, Louise, Romani, Rossana, Bentley, Ian, Whitbred, Tim, Fowler, Simon, Gavin, John, Magee, Alan, Watson, Tara, Nightingale, Kari, Marius, Phedra, Summerton, Eloise, Locke, Emily, Honey, Thomas, Lingwood, Aidan, de la Haye, Anastasia, Elliott, Ryan Stephen, Underwood, Karen, King, Mikayala, Davies-Dear, Sharon, Horsfall, Emily, Chalwin, Olivia, Burton, Holly, Edwards, Christopher J, Welham, Benjamin, Garrahy, Sarah, Hall, Fran, Ladikou, Eleni, Mullan, Dee, Hansen, Daniel, Campbell, Marion, Dos Santos, Filipa, Habash-Bailey, Haniah, Lakeman, Nicki, Branney, Debbie, Vamplew, Luke, Hogan, Alison, Frankham, Jorden, Wiselka, Martin, Vail, Dennyl, Wenn, Victoria, Renals, Valerie, Ellis, Kate, Lewis-Taylor, Jessica, Magan, Javier, Hardy, Anna, Appleby, Kim, Munro, Alasdair P S, Janani, Leila, Cornelius, Victoria, Aley, Parvinder K, Babbage, Gavin, Baxter, David, Bula, Marcin, Cathie, Katrina, Chatterjee, Krishna, Dodd, Kate, Enever, Yvanne, Gokani, Karishma, Goodman, Anna L, Green, Christopher A, Harndahl, Linda, Haughney, John, Hicks, Alexander, van der Klaauw, Agatha A, Kwok, Jonathan, Lambe, Teresa, Libri, Vincenzo, Llewelyn, Martin J, McGregor, Alastair C, Minassian, Angela M, Moore, Patrick, Mughal, Mehmood, Mujadidi, Yama F, Murira, Jennifer, Osanlou, Orod, Osanlou, Rostam, Owens, Daniel R, Pacurar, Mihaela, Palfreeman, Adrian, Pan, Daniel, Rampling, Tommy, Regan, Karen, Saich, Stephen, Salkeld, Jo, Saralaya, Dinesh, Sharma, Sunil, Sheridan, Ray, Sturdy, Ann, Thomson, Emma C, Todd, Shirley, Twelves, Chris, Read, Robert C, Charlton, Sue, Hallis, Bassam, Ramsay, Mary, Andrews, Nick, Nguyen-Van-Tam, Jonathan S, Snape, Matthew D, Liu, Xinxue, and Faust, Saul N

Published
2021
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10. One of two Forbes laundry rooms out of commission following fire

Author

Graham, Victoria DaviesHallie

Subjects
Fire-departments, News, opinion and commentary, Sports and fitness
Abstract

Byline: Victoria DaviesHallie Graham A dryer in the laundry room of Forbes College Main caught fire around 3 p.m. on Sunday, Feb. 18. The main building was evacuated, and the [...]

Published
2024

16. Pathogenesis of Rift Valley Fever Virus in a BALB/c Mouse Model Is Affected by Virus Culture Conditions and Sex of the Animals.

Author

Graham, Victoria A., Easterbrook, Linda, Kennedy, Emma, Rayner, Emma, Findlay-Wilson, Stephen, Flett, Lucy, Wise, Emma Louise, Treagus, Samantha, Fotheringham, Susan, Kempster, Sarah, Almond, Neil, and Dowall, Stuart

Subjects
*RIFT Valley fever, *LABORATORY mice, *MICE, *ANIMAL disease models, *VIRAL tropism, *PATHOGENESIS
Abstract

Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen causing disease in livestock and humans. Whilst initially restricted to the African continent, recent spread to the Arabian Peninsula has highlighted the likelihood of entry into new regions. Due to the absence of a regulatory-approved human vaccine, work is ongoing to develop and assess countermeasures. As such, small animal models play a pivotal role in providing information on disease pathogenesis and elucidating which intervention strategies confer protection. To develop and establish the BALB/c mouse model, we challenged mice with RVFV grown from two separate cell lines: one derived from mosquitoes (C6/36) and the other mammalian derived (Vero E6). Following infection, we assessed the clinical course of disease progression at days 1 and 3 post-challenge and evaluated viral tropism and immune analytes. The results demonstrated that RVFV infection was affected by the cell line used to propagate the challenge virus, with those grown in insect cells resulting in a more rapid disease progression. The lowest dose that caused uniform severe disease remained the same across both virus preparations. In addition, to demonstrate reproducibility, the lowest dose was used for a subsequent infection study using male and female animals. The results further demonstrated that male mice succumbed to infection more rapidly than their female counterparts. Our results establish an RVFV mouse model and key parameters that affect the course of disease progression in BALB/c mice. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Adenoviral vectored vaccination protects against Crimean-Congo Haemorrhagic Fever disease in a lethal challenge model

Author

Saunders, Jack E., primary, Gilbride, Ciaran, additional, Dowall, Stuart, additional, Morris, Susan, additional, Ulaszewska, Marta, additional, Spencer, Alexandra J., additional, Rayner, Emma, additional, Graham, Victoria A., additional, Kennedy, Emma, additional, Thomas, Kelly, additional, Hewson, Roger, additional, Gilbert, Sarah C., additional, Belij-Rammerstorfer, Sandra, additional, and Lambe, Teresa, additional

Published
2023
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20. Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays

Author

Tyrrell, Beatrice E., primary, Kumar, Abhinav, additional, Gangadharan, Bevin, additional, Alonzi, Dominic, additional, Brun, Juliane, additional, Hill, Michelle, additional, Bharucha, Tehmina, additional, Bosworth, Andrew, additional, Graham, Victoria, additional, Dowall, Stuart, additional, Miller, Joanna L., additional, and Zitzmann, Nicole, additional

Published
2023
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21. Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection

Author

Stettler, Karin, Beltramello, Martina, Espinosa, Diego A., Graham, Victoria, Cassotta, Antonino, Bianchi, Siro, Vanzetta, Fabrizia, Minola, Andrea, Jaconi, Stefano, Mele, Federico, Foglierini, Mathilde, Pedotti, Mattia, Simonelli, Luca, Dowall, Stuart, Atkinson, Barry, Percivalle, Elena, Simmons, Cameron P., Varani, Luca, Blum, Johannes, Baldanti, Fausto, Cameroni, Elisabetta, Hewson, Roger, Harris, Eva, Lanzavecchia, Antonio, Sallusto, Federica, and Corti, Davide

Published
2016

22. STIM1 interacts with HCN4 channels to coordinate diastolic depolarization in the mouse Sinoatrial node

Author

Zhang, Hengtao, Graham, Victoria, Nepliouev, Igor, Stiber, Jonathan A., and Rosenberg, Paul

Subjects
Article
Abstract

Cardiomyocytes in the sinoatrial node (SAN) are specialized to undergo spontaneous diastolic depolarization (DD) to create action potentials (AP) that serve as the origin of the heartbeat. Two cellular clocks govern DD: the membrane clock where ion channels contribute ionic conductance to create DD and the Ca2+clock where rhythmic Ca2+release from sarcoplasmic reticulum (SR) during diastole contributes pacemaking. How the membrane and Ca2+clocks interact to synchronize and drive DD is not well understood. Here, we identified stromal interaction molecule 1 (STIM1), the activator of store operated Ca2+entry (SOCE), in the P-cell cardiomyocytes of the SAN. Functional studies from STIM1 KO mice reveal dramatic changes in properties of AP and DD. Mechanistically, we show that STIM1 regulates the funny currents and HCN4 channels that are required to initiate DD and maintain sinus rhythm in mice. Taken together, our studies suggest that STIM1 acts as a sensor for both the Ca2+and membrane clocks for mouse SAN for cardiac pacemaking.

Published
2023

23. Implementing Budget 2023: Key Developments For Financial Services Providers

Author

Graham, Victoria

Subjects
Bills, Legislative, Financial services industry -- Laws, regulations and rules, Criminal law -- Interpretation and construction, National budgets -- Laws, regulations and rules, Money laundering -- Laws, regulations and rules, Government regulation, Financial services industry, Business, international, Canada. Proceeds of Crime (Money Laundering) and Terrorist Financing Act 2000, Canada. Criminal Code
Abstract

On April 20, 2023, the government of Canada introduced Bill C-47, The Budget Implementation Act (Bill C-47) which proposes to implement many of the federal government's key proposals presented in [...]

Published
2023

24. Retail Payment Activities Act: Draft Regulations Published For Comment

Author

Graham, Victoria

Subjects
Bank of Canada -- Laws, regulations and rules, Canada. Department of Finance Canada -- Powers and duties, Business, international, Canada. Retail Payment Activities Act (Draft)
Abstract

On February 11, 2023, the Department of Finance published draft regulations (the draft Regulations) under the Retail Payment Activities Act (the RPAA). The draft Regulations propose significant and, in some [...]

Published
2023

25. Prolonged Zika Virus RNA Detection in Semen of Immunosuppressed Patient

Author

Petridou, Christina, Bonsall, David, Ahmed, Aleem, Roberts, Mark, Bell, Carolyn, de Cesare, Mariateresa, Bowden, Rory, Graham, Victoria, Bailey, Daniel, Simpson, Andrew, and Aarons, Emma

Subjects
Zika virus, Immunotherapy, RNA, Genes, Health
Abstract

Detection of Zika virus RNA in semen was described previously in an immunocompetent man 370 days after symptom onset; envelope and precursor of M protein gene sequencing indicated high genetic [...]

Published
2019

28. Financial Services Regulation In 2022: Bridging The Gaps

Author

Graham, Victoria

Subjects
Crypto-currencies -- Laws, regulations and rules, Financial services industry -- Laws, regulations and rules, Online assets -- Laws, regulations and rules, Payment -- Laws, regulations and rules, Money laundering -- Laws, regulations and rules, Government regulation, Financial services industry, Business, international
Abstract

Following key legislative and regulatory developments in the Canadian financial services space over the past several years, regulators focused in 2022 on bridging regulatory gaps, fleshing out details and working [...]

Published
2022

29. Development of humanised antibodies for Crimean-Congo Haemorrhagic fever virus: Comparison of hybridoma-based versus phage library techniques

Author

Dowall, Stuart D., Graves, Leo P., Kennedy, Emma, Graham, Victoria A., Alakeely, Riyadh A., Chambers, Adam, Possee, Robert D., King, Linda A., and Hewson, Roger

Subjects
Immunology, Immunology and Allergy
Abstract

Humanised antibodies targeting Crimean-Congo Haemorrhagic virus (CCHFV) are needed for the development and standardisation of serological assays. These assays are needed to address a shortfall in available tests that meet regulatory diagnostic standards and to aid surveillance activities to extend knowledge on the distribution of CCHFV. To generate a humanised monoclonal antibody against CCHFV, we have compared two methods: the traditional mouse hybridoma approach with subsequent sequencing and humanisation of antibodies versus a non-animal alternative using a human combinatorial antibody library (HuCAL). Our results demonstrated that the mouse hybridoma followed by humanisation protocol gave higher affinity antibodies. Whilst not yet able to demonstrate the generation of equivalent humanised antibodies without the use of animals, sequencing data enables the subsequent production of recombinant antibodies, thus providing a reduction in future animal usage for this application. Ultimately, our report provides information on development of a humanised standardised control, which can form an important positive control component of serological assays against CCHFV.

Published
2022

30. Quasi-monocrystalline silicon for low-noise end mirrors in cryogenic gravitational-wave detectors

Author

Kiessling, Frank M., primary, Murray, Peter G., additional, Kinley-Hanlon, Maya, additional, Buchovska, Iryna, additional, Ervik, Torunn K., additional, Graham, Victoria, additional, Hough, Jim, additional, Johnston, Ross, additional, Pietsch, Mike, additional, Rowan, Sheila, additional, Schnabel, Roman, additional, Tait, Simon C., additional, Steinlechner, Jessica, additional, and Martin, Iain W., additional

Published
2022
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33. Establishment of a Nipah Virus Disease Model in Hamsters, including a Comparison of Intranasal and Intraperitoneal Routes of Challenge.

Author

Findlay-Wilson, Stephen, Flett, Lucy, Salguero, Francisco J., Ruedas-Torres, Ines, Fotheringham, Susan, Easterbrook, Linda, Graham, Victoria, and Dowall, Stuart

Subjects
NIPAH virus, VIRUS diseases, HAMSTERS, MEDICAL model, FOOD contamination, VACCINE approval
Abstract

Nipah virus (NiV) is an emerging pathogen that can cause severe respiratory illness and encephalitis in humans. The main reservoir is fruit bats, distributed across a large geographical area that includes Australia, Southeast Asia, and Africa. Incursion into humans is widely reported through exposure of infected pigs, ingestion of contaminated food, or through contact with an infected person. With no approved treatments or vaccines, NiV poses a threat to human public health and has epidemic potential. To aid with the assessment of emerging interventions being developed, an expansion of preclinical testing capability is required. Given variations in the model parameters observed in different sites during establishment, optimisation of challenge routes and doses is required. Upon evaluating the hamster model, an intranasal route of challenge was compared with intraperitoneal delivery, demonstrating a more rapid dissemination to wider tissues in the latter. A dose effect was observed between those causing respiratory illness and those resulting in neurological disease. The data demonstrate the successful establishment of the hamster model of NiV disease for subsequent use in the evaluation of vaccines and antivirals. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Evolving Trends in the Management of Acute Appendicitis During COVID-19 Waves: The ACIE Appy II Study

Author

Pata, Francesco, Di Martino, Marcello, Podda, Mauro, Di Saverio, Salomone, Ielpo, Benedetto, Pellino, Gianluca, Julio, Abba, Alshamrani, Abdullah, Alturkistani, Abdullah, Alghamdi, Abdulrahman, Almalki, Abdulrahman, Orengia, Adam, Kuvvetli, Adnan, Pisanu, Adolfo, Smith, Adrian, Treviño Figueroa, Adriana Michelle, Nacion, Aeris Jane, Alhazmi, Ahmad, Bouhuwaish, Ahmad, Khalid, Ahmad, Alsufyani, Ahmed, Rubio, Ainhoa Valle, Bavikatte, Akshay, Kumar, Akshay, Jamiri, Al-Radjid, de San Ildefonso Pereira, Alberto, Porcu, Alberto, Sartori, Alberto, Rocca, Aldo, Sretenovic, Aleksandar, Anselmo, Alessandro, De Luca, Alessandro, Charalabopoulos, Alexandros, Tzivanakis, Alexios, Bandin, Alfonso, Nájar, Alfonso, Frontali, Alice, Faisal, Alsulaimani, Roldan, Amaia Martínez, Hamid, Amal, André, Ana, Minaya-Bravo, Ana, Das, Andre, Bondurri, Andrea, Costanzi, Andrea, Lucchi, Andrea, Mihailescu, Andrei, Police, Andrea, Zuchini, Andres Mendoza, Romano, Angela, Iossa, Angelo, Chessa, Antonella, Tromba, Antonella, Castaldi, Antonio, Brillantino, Antonio, Ferronetti, Antonio, Giuliani, Antonio, Ramos-De la Medina, Antonio, Tarasconi, Antonio, Picciariello, Arcangelo, Ioannidis, Argyrios, Leppäniemi, Ari, Rashid, Arshad, Mitul, Ashrarur Rahman, Mehraj, Asif, Laharwal, Asim, Iqbal, Atif, Liarakos, Athanasios, Marinis, Athanasios, de Andrés-Asenjo, Beatriz, Matías-García, Belén, De Simone, Belinda, Creavin, Ben, Stubbs, Ben, Goh, Brian, Jovanovic, Branislav, Sensi, Bruno, Gazia, Carlo, Cerdán, Carlos, Díaz, Carlos Javier Gómez, Chacón, Carlos Petrola, Yánez, Carlos, Faro, Carmelo Lo, Reinke, Caroline, Dominguez, Casandra, Paranjape, Charudutt, Thomas, Charlotte, Fung, Chia Chi, De Lucia, Chiara, Jennifer, Chiu Hiu Fung, Ovalle-Chao, Christian, Guerci, Claudio, Kenington, Cleo, Gica, Corina, Folliero, Cristina, Varela, Cristopher, Popowich, Daniel, Delogu, Daniele, Zigiotto, Daniele, Vinci, Danilo, D’Antonio, Dario, Merlini, David Alessio, Merlini, David, Moro-Valdezate, David, Keller, Deborah, Nicolaescu, Diana Cristiana, Sasia, Diego, Rodas, Edgar, Linardoutsos, Dimitrios, Russello, Domenico, Nájar-Castañeda, Pedro Alfonso, Stavrou, Habil Gregor, Rosso, Edoardo, Saladino, Edoardo, Ricciardi, Edoardo, Smith-Singares, Eduardo, Baili, Efstratia, Douka, Eleftheria, Guaitoli, Eleonora, Francone, Elisa, Vaterlini, Elisa Maria, Pierobon, Elisa Sefora, Morales, Emilio, Ros, Emilio Peña, Benzoni, Enrico, Erdas, Enrico, Pinotti, Enrico, Colás-Ruiz, Enrique, Laterza, Ernesto, Foianini, Esteban, Cardamone, Eugenia, Licardie, Eugenio, Marino, Fabio, Alsofyani, Fahad, Qahtani, Fahad, Khan, Farhan, Maraska, Fatlum, Saliu, Fatmir, Madrid, Fausto, Rosa, Fausto, Luvisetto, Federico, Alconchel, Felipe, Pareja-Ciuro, Felipe, Neves, Fernanda, Agresta, Ferdinando, Cordera, Fernando, Pardo, Fernando, Mendoza-Moreno, Fernando, Munoz-Flores, Fernando, Silvestri, Francesca Maria, Tropeano, Francesca Paola, Pecchini, Francesca, Serio, Francesca, Colombo, Francesco, Di Marzo, Francesco, Ferrara, Francesco, Lancellotti, Francesco, Litta, Francesco, Martini, Francesco, Roscio, Francesco, Blanco-Antona, Francisco, Barcenas, Francisco Javier Quezada, Schlottmann, Francisco, Herrera-Almario, Gabriel, van Ramshorst, Gabrielle, Gallo, Gaetano, Luglio, Gaetano, Kampouroglou, Georgios, Papadopoulos, Georgios, Arredondo, Gerardo, Calini, Giacomo, Formisano, Giampaolo, Galiffa, Giampaolo, Palini, Gian Marco, Colucci, Gianluca, Pagano, Gianluca, Vanni, Gianluca, Pattacini, Gianmaria Casoni, Gravante, Gianpiero, Lisi, Giorgio, Bellanova, Giovanni, De Nobili, Giovanni, Necchi, Giovanni Sammy, Sinibaldi, Giovanni, Bacchiocchi, Giulia, Bagaglini, Giulia, Maggi, Giulia, Izzo, Giuliano, Argenio, Giulio, Brisinda, Giuseppe, Esposito, Giuseppe, Frazzetta, Giuseppe, De Luca, Giuseppe Massimiliano, Nigri, Giuseppe, Sica, Giuseppe, Martin-Martin, Gonzalo, Ugon, Gustavo Armand, Martinez-Mier, Gustavo, Machain Vega, Gustavo Miguel, Nari, Gustavo, Nikaj, Herald, Neri, Ignacio, San Roman, Igor Alberdi, Fidoshev, Iliya, Martínez, Iñaki, Negoi, Ionut, Ortega, Irene, Vicente Rodríguez, Irune, Cornejo, Isabel, Mora-Guzmán, Ismael, al-Najami, Issam, Romic, Ivan, Balciscueta, Izaskun, Olivier, James, Lammel-Lindemann, Jan, Dziakova, Jana, Salinas, Javier, Jovanovic, Jelena Pejanovic, Reyes, Jeryl Anne Silvia, Salas, Joanne, Diaz-Elizondo, Jose Antonio, Parreira, Jose Gustavo, Bellido, Juan, Salamea, Juan, Martín del Olmo, Juan Carlos, Ordoñez, Juliana María, Junaid, Sofi, Davies, Justin, Sahnan, Kapil, Bekele, Kebebe, Voon, Kelvin, Siragusa, Leandro, Petagna, Lorenzo, Ferrario, Luca, Giordano, Luca, Nespoli, Luca, Pio, Luca, Moletta, Lucia, Curella, Luciano, Taglietti, Lucio, Bonavina, Luigi, Conti, Luigi, Pérez-Sánchez, Luis Eduardo, Cabrera Vargas, Luis Felipe, Sánchez-Guillén, Luis, Tallon-Aguilar, Luis, Khan, Mansoor, Spampinato, Marcello Giuseppe, Viola, Marcelo, Malet, Marcelo Viola, Angrisani, Marco, Calussi, Marco, Catarci, Marco, Giordano, Marco, Materazzo, Marco, Milone, Marco, Pellicciaro, Marco, Marino, Marco Vito, Moreno Villamizar, María Daniela, Lolli, Maria Giulia, Bellini, Maria Irene, Lemma, Maria, Chiarello, Maria Michela, Montes-Manrique, Mario, Rodriguez-Lopez, Mario, Serradilla-Martín, Mario, Peter, Mark, Paniagua-García-Señoráns, Marta, Rutegård, Martin, Salö, Martin, Silveri, Massimiliano, Veroux, Massimiliano, Nardi, Matteo, Rottoli, Matteo, Tolonen, Matti, Pedraza Ciro, Mauricio, Zuluaga, Mauricio, Iacobone, Maurizio, Montuori, Mauro, Ali, Mazin, García Domínguez, Melody, Paola, Menna Maria, Piccoli, Micaela, Campanelli, Michela, De Rosa, Michele, Manigrasso, Michele, Maruccia, Michele, Torre, Michele, Zuolo, Michele, Pera, Miguel, Weerasekera, Mihiri, Prieto, Mikel, Thway, Min Myat, Shaat, Mohamed, Azfar, Mohammad, Shalaby, Mostafa, Raza, Muhammad Asif, Younis, Muhammad Umar, Elhadi, Muhammed, Ali, Mujahid, Althomali, Musab, Al Amri, Nadiah, Dudi-Venkata, Nagendra, Alselaim, Nahar, Smart, Neil, Trelles, Nelson, Falco, Nicolò, Petrucciani, Niccolo, Antonacci, Nicola, Cillara, Nicola, Gica, Nicolae, Pecorelli, Nicolò, Tamini, Nicolò, Machairas, Nikolaos, Feituri, Nura, Ortega Torrecilla, Nuria, Avila Mercado, Octavio, Alaamer, Ohood, Irkorucu, Oktay, Alsherif, Omar, Buonomi, Oreste Claudio, Valles-Guerra, Orestes, Ioannidis, Orestis, Hernández Palmas, Oscar Isaac, Sanz Guadarrama, Oscar, Bozbiyik, Osman, Rodrigues, Pablo, Milito, Pamela, Panaccio, Paolo, Dorovinis, Panagiotis, Prieto, Paola, Baroffio, Paolo, Marsanic, Patrizia, Ajawin, Pawel, Koh, Peng Soon, Anoldo, Pietro, Major, Piotr, Alharthi, Qasem, Lui, Rashid, Caruso, Riccardo, Brady, Richard, Rattan, Rishi, Singhal, Rishi, Angelico, Roberta, Isernia, Roberta Maria, Tutino, Roberta, Peltrini, Roberto, Tejos, Rodrigo, Fajardo, Roosevelt, Elia, Rossella, Morales-Conde, Salvador, Benli, Sami, Fuentes, Sara, de las Casas, Sara Gortázar, de Guzmán Aragón, Sara Ortiz, Vertaldi, Sara, Awad, Selmy, Gentilli, Sergio, Weckmann Lujan, Sergio Alberto, Tayar, Serkan, Althobaiti, Shabab, Di Giovanni, Silvia, Ghedan, Soliman, Pérez-Bertólez, Sonia, Chiappetta, Sonja, Delis, Spiros, Scaringi, Stefano, Çetinkünar, Süleyman, Kykalos, Stylianos, Muhammad Ali, Syed, Krivan, Sylvia, Fung, Tak Lit Derek, Delko, Tarik, Nicolás López, Tatiana, De Campos, Tercio, Calderón Duque, Teresa, Perra, Teresa, Liakakos, Theodore, Daskalakis, Theodoros, Koëter, Tijmen, Zalla, Tiku, González, Tomás Elosua, Campagnaro, Tommaso, Oumar, Toure Alpha, Grossi, Ugo, Sosa, Valentina, Testa, Valentina, Tomajer, Valentina, Andriola, Valeria, Tonini, Valeria, Celentano, Valerio, Voglino, Valerio, Katta, Venkateswara Rao, García Orozco, Víctor Hugo, Turrado-Rodriguez, Victor, Visag-Castillo, Victor, Graham, Victoria, Rachkov, Viktor, Papagni, Vincenzo, Vigorita, Vincenzo, Jiménez Carneros, Virginia, Bellato, Vittoria, Bechstein, Wolf, Altinel, Yuksel, Balciscueta, Zutoia, Pata, Francesco, Di Martino, Marcello, Podda, Mauro, Di Saverio, Salomone, Ielpo, Benedetto, Pellino, Gianluca, Luglio, Gaetano, Pata, F, Di Martino, M, Podda, M, Di Saverio, S, Ielpo, B, Pellino, G, Julio, A, Alshamrani, A, Alturkistani, A, Alghamdi, A, Almalki, A, Orengia, A, Kuvvetli, A, Pisanu, A, Smith, A, Trevino Figueroa, A, Nacion, A, Alhazmi, A, Bouhuwaish, A, Khalid, A, Alsufyani, A, Rubio, A, Bavikatte, A, Kumar, A, Jamiri, A, de San Ildefonso Pereira, A, Porcu, A, Sartori, A, Rocca, A, Sretenovic, A, Anselmo, A, De Luca, A, Charalabopoulos, A, Tzivanakis, A, Bandin, A, Najar, A, Frontali, A, Faisal, A, Roldan, A, Hamid, A, Andre, A, Minaya-Bravo, A, Das, A, Bondurri, A, Costanzi, A, Lucchi, A, Mihailescu, A, Police, A, Zuchini, A, Romano, A, Iossa, A, Chessa, A, Tromba, A, Castaldi, A, Brillantino, A, Ferronetti, A, Giuliani, A, Ramos-De la Medina, A, Tarasconi, A, Picciariello, A, Ioannidis, A, Leppaniemi, A, Rashid, A, Mitul, A, Mehraj, A, Laharwal, A, Iqbal, A, Liarakos, A, Marinis, A, de Andres-Asenjo, B, Matias-Garcia, B, De Simone, B, Creavin, B, Stubbs, B, Goh, B, Jovanovic, B, Sensi, B, Gazia, C, Cerdan, C, Diaz, C, Chacon, C, Yanez, C, Faro, C, Reinke, C, Dominguez, C, Paranjape, C, Thomas, C, Fung, C, De Lucia, C, Jennifer, C, Ovalle-Chao, C, Guerci, C, Kenington, C, Gica, C, Folliero, C, Varela, C, Popowich, D, Delogu, D, Zigiotto, D, Vinci, D, D'Antonio, D, Merlini, D, Moro-Valdezate, D, Keller, D, Nicolaescu, D, Sasia, D, Rodas, E, Linardoutsos, D, Russello, D, Najar-Castaneda, P, Stavrou, H, Rosso, E, Saladino, E, Ricciardi, E, Smith-Singares, E, Baili, E, Douka, E, Guaitoli, E, Francone, E, Vaterlini, E, Pierobon, E, Morales, E, Ros, E, Benzoni, E, Erdas, E, Pinotti, E, Colas-Ruiz, E, Laterza, E, Foianini, E, Cardamone, E, Licardie, E, Marino, F, Alsofyani, F, Qahtani, F, Khan, F, Maraska, F, Saliu, F, Madrid, F, Rosa, F, Luvisetto, F, Alconchel, F, Pareja-Ciuro, F, Neves, F, Agresta, F, Cordera, F, Pardo, F, Mendoza-Moreno, F, Munoz-Flores, F, Silvestri, F, Tropeano, F, Pecchini, F, Serio, F, Colombo, F, Di Marzo, F, Ferrara, F, Lancellotti, F, Litta, F, Martini, F, Roscio, F, Blanco-Antona, F, Barcenas, F, Schlottmann, F, Herrera-Almario, G, van Ramshorst, G, Gallo, G, Luglio, G, Kampouroglou, G, Papadopoulos, G, Arredondo, G, Calini, G, Formisano, G, Galiffa, G, Palini, G, Colucci, G, Pagano, G, Vanni, G, Pattacini, G, Gravante, G, Lisi, G, Bellanova, G, De Nobili, G, Necchi, G, Sinibaldi, G, Bacchiocchi, G, Bagaglini, G, Maggi, G, Izzo, G, Argenio, G, Brisinda, G, Esposito, G, Frazzetta, G, De Luca, G, Nigri, G, Sica, G, Martin-Martin, G, Ugon, G, Martinez-Mier, G, Machain Vega, G, Nari, G, Nikaj, H, Neri, I, San Roman, I, Fidoshev, I, Martinez, I, Negoi, I, Ortega, I, Vicente Rodriguez, I, Cornejo, I, Mora-Guzman, I, al-Najami, I, Romic, I, Balciscueta, I, Olivier, J, Lammel-Lindemann, J, Dziakova, J, Salinas, J, Jovanovic, J, Reyes, J, Salas, J, Diaz-Elizondo, J, Parreira, J, Bellido, J, Salamea, J, Martin del Olmo, J, Ordonez, J, Junaid, S, Davies, J, Sahnan, K, Bekele, K, Voon, K, Siragusa, L, Petagna, L, Ferrario, L, Giordano, L, Nespoli, L, Pio, L, Moletta, L, Curella, L, Taglietti, L, Bonavina, L, Conti, L, Perez-Sanchez, L, Cabrera Vargas, L, Sanchez-Guillen, L, Tallon-Aguilar, L, Khan, M, Spampinato, M, Viola, M, Malet, M, Angrisani, M, Calussi, M, Catarci, M, Giordano, M, Materazzo, M, Milone, M, Pellicciaro, M, Marino, M, Moreno Villamizar, M, Lolli, M, Bellini, M, Lemma, M, Chiarello, M, Montes-Manrique, M, Rodriguez-Lopez, M, Serradilla-Martin, M, Peter, M, Paniagua-Garcia-Senorans, M, Rutegard, M, Salo, M, Silveri, M, Veroux, M, Nardi, M, Rottoli, M, Tolonen, M, Pedraza Ciro, M, Zuluaga, M, Iacobone, M, Montuori, M, Ali, M, Garcia Dominguez, M, Paola, M, Piccoli, M, Campanelli, M, De Rosa, M, Manigrasso, M, Maruccia, M, Torre, M, Zuolo, M, Pera, M, Weerasekera, M, Prieto, M, Thway, M, Shaat, M, Azfar, M, Shalaby, M, Raza, M, Younis, M, Elhadi, M, Althomali, M, Al Amri, N, Dudi-Venkata, N, Alselaim, N, Smart, N, Trelles, N, Falco, N, Petrucciani, N, Antonacci, N, Cillara, N, Gica, N, Pecorelli, N, Tamini, N, Machairas, N, Feituri, N, Ortega Torrecilla, N, Avila Mercado, O, Alaamer, O, Irkorucu, O, Alsherif, O, Buonomi, O, Valles-Guerra, O, Ioannidis, O, Hernandez Palmas, O, Sanz Guadarrama, O, Bozbiyik, O, Rodrigues, P, Milito, P, Panaccio, P, Dorovinis, P, Prieto, P, Baroffio, P, Marsanic, P, Ajawin, P, Koh, P, Anoldo, P, Major, P, Alharthi, Q, Lui, R, Caruso, R, Brady, R, Rattan, R, Singhal, R, Angelico, R, Isernia, R, Tutino, R, Peltrini, R, Tejos, R, Fajardo, R, Elia, R, Morales-Conde, S, Benli, S, Fuentes, S, de las Casas, S, de Guzman Aragon, S, Vertaldi, S, Awad, S, Gentilli, S, Weckmann Lujan, S, Tayar, S, Althobaiti, S, Di Giovanni, S, Ghedan, S, Perez-Bertolez, S, Chiappetta, S, Delis, S, Scaringi, S, Cetinkunar, S, Kykalos, S, Muhammad Ali, S, Krivan, S, Fung, T, Delko, T, Nicolas Lopez, T, De Campos, T, Calderon Duque, T, Perra, T, Liakakos, T, Daskalakis, T, Koeter, T, Zalla, T, Gonzalez, T, Campagnaro, T, Oumar, T, Grossi, U, Sosa, V, Testa, V, Tomajer, V, Andriola, V, Tonini, V, Celentano, V, Voglino, V, Katta, V, Garcia Orozco, V, Turrado-Rodriguez, V, Visag-Castillo, V, Graham, V, Rachkov, V, Papagni, V, Vigorita, V, Jimenez Carneros, V, Bellato, V, Bechstein, W, Altinel, Y, Balciscueta, Z, Institut Català de la Salut, [Pata F] General Surgery Unit, UOC di Chirurgia, Nicola Giannettasio Hospital, CS, Italy. La Sapienza University, Rome, Italy. [Di Martino M] Division of Hepatobiliary and Liver Transplantation Surgery, A.O.R.N. Cardarelli, Naples, Italy. [Podda M] Department of Surgical Science, University of Cagliari, Cagliari, Italy. [Di Saverio S] Department of Surgery, Madonna del Soccorso General Hospital, San Benedetto del Tronto, Italy. [Ielpo B] Hepatobiliary division, Hospital del Mar, Universitat Pompeu Fabra, Barcelona, Spain. [Pellino G] Department of Advanced Medical and Surgical Sciences, Universitá degli Studi della Campania ‘‘Luigi Vanvitelli’’, Policlinico CS, Naples, Italy. Unitat de Cirurgia de Còlon i Recte, Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], covid-19, surgery, coronavirus, sars-cov-2, appendicectomy, laparoscopy, nom, management, Enquestes, Apendicectomia, COVID-19 (Malaltia), surgery, Surgical Procedures, Operative::Digestive System Surgical Procedures::Appendectomy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Apendicitis, Pandèmia de COVID-19, 2020, Appendectomy, Humans, Appendiciti, Pandemics, Cirurgia, Pandemic, SARS-CoV-2, COVID-19, Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Digestive System Diseases::Gastrointestinal Diseases::Appendicitis [DISEASES], Otros calificadores::Otros calificadores::/cirugía [Otros calificadores], técnicas de investigación::métodos epidemiológicos::recopilación de datos::encuestas y cuestionarios [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Appendicitis, Apendicitis - Cirurgia, Other subheadings::Other subheadings::/surgery [Other subheadings], Settore MED/18, Settore MED/18 - Chirurgia Generale, Acute Disease, enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedades del sistema digestivo::enfermedades gastrointestinales::apendicitis [ENFERMEDADES], intervenciones quirúrgicas::procedimientos quirúrgicos del sistema digestivo::apendicectomía [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Human
Abstract

Background In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide.

Published
2022

35. Development of a cost-effective ovine antibody-based therapy against SARS-CoV-2 infection and contribution of antibodies specific to the spike subunit proteins

Author

Findlay-Wilson, Stephen, primary, Easterbrook, Linda, additional, Smith, Sandra, additional, Pope, Neville, additional, Humphries, Gareth, additional, Schuhmann, Holger, additional, Ngabo, Didier, additional, Rayner, Emma, additional, Otter, Ashley David, additional, Coleman, Tom, additional, Hicks, Bethany, additional, Graham, Victoria Anne, additional, Halkerston, Rachel, additional, Apostolakis, Kostis, additional, Taylor, Stephen, additional, Fotheringham, Susan, additional, Horton, Amanda, additional, Tree, Julia Anne, additional, Wand, Matthew, additional, Hewson, Roger, additional, and Dowall, Stuart David, additional

Published
2022
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37. FINTRAC Retracts Merchant Servicing And Payment Processing Exemptions

Author

Graham, Victoria

Subjects
Financial services industry -- Laws, regulations and rules, Electronic funds transfer systems -- Laws, regulations and rules, Amendments (Parliamentary practice) -- Forecasts and trends, Government regulation, Market trend/market analysis, Financial services industry, Business, international
Abstract

On April 27, 2022, the Financial Transactions and Reports Analysis Centre of Canada (FINTRAC) issued a notice that the recent amendments to the Proceeds of Crime (Money Laundering) and Terrorist [...]

Published
2022

38. Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial

Author

Munro, Alasdair P S, primary, Janani, Leila, additional, Cornelius, Victoria, additional, Aley, Parvinder K, additional, Babbage, Gavin, additional, Baxter, David, additional, Bula, Marcin, additional, Cathie, Katrina, additional, Chatterjee, Krishna, additional, Dodd, Kate, additional, Enever, Yvanne, additional, Gokani, Karishma, additional, Goodman, Anna L, additional, Green, Christopher A, additional, Harndahl, Linda, additional, Haughney, John, additional, Hicks, Alexander, additional, van der Klaauw, Agatha A, additional, Kwok, Jonathan, additional, Lambe, Teresa, additional, Libri, Vincenzo, additional, Llewelyn, Martin J, additional, McGregor, Alastair C, additional, Minassian, Angela M, additional, Moore, Patrick, additional, Mughal, Mehmood, additional, Mujadidi, Yama F, additional, Murira, Jennifer, additional, Osanlou, Orod, additional, Osanlou, Rostam, additional, Owens, Daniel R, additional, Pacurar, Mihaela, additional, Palfreeman, Adrian, additional, Pan, Daniel, additional, Rampling, Tommy, additional, Regan, Karen, additional, Saich, Stephen, additional, Salkeld, Jo, additional, Saralaya, Dinesh, additional, Sharma, Sunil, additional, Sheridan, Ray, additional, Sturdy, Ann, additional, Thomson, Emma C, additional, Todd, Shirley, additional, Twelves, Chris, additional, Read, Robert C, additional, Charlton, Sue, additional, Hallis, Bassam, additional, Ramsay, Mary, additional, Andrews, Nick, additional, Nguyen-Van-Tam, Jonathan S, additional, Snape, Matthew D, additional, Liu, Xinxue, additional, Faust, Saul N, additional, Riordan, Andrew, additional, Ustianowski, Andrew, additional, Rogers, Chris A, additional, Hughes, Stephen, additional, Longshaw, Laura, additional, Stockport, Jane, additional, Hughes, Rachel, additional, Grundy, Lynne, additional, Tudor Jones, Lona, additional, Guha, Arpan, additional, Snashall, Emma, additional, Eadsforth, Tom, additional, Reeder, Sally, additional, Storton, Kim, additional, Munusamy, Malathi, additional, Tandy, Bridget, additional, Egbo, Akamino, additional, Cox, Stephen, additional, Ahmed, Nabeela Nazir, additional, Shenoy, Anil, additional, Bousfield, Rachel, additional, Wixted, Donna, additional, Gutteridge, Helen, additional, Mansfield, Becky, additional, Herbert, Christopher, additional, Holliday, Kyra, additional, Calderwood, James, additional, Barker, Dominique, additional, Brandon, Jacqueline, additional, Tulloch, Hayley, additional, Colquhoun, Suzie, additional, Thorp, Helen, additional, Radford, Helen, additional, Evans, Julie, additional, Baker, Helena, additional, Thorpe, Jeanette, additional, Batham, Sally, additional, Hailstone, Jessica, additional, Phillips, Rachael, additional, Kumar, Dileep, additional, Westwell, Fran, additional, Makia, Fiona, additional, Hopkins, NinaSimone, additional, Barcella, Lara, additional, Mpelembue, Mushiya, additional, dabagh, Maja, additional, lang, Matilda, additional, khan, Farida, additional, Adebambo, Olumide, additional, Chita, Sunder, additional, Corrah, Tumena, additional, Whittington, Ashley, additional, John, Laurence, additional, Roche, Siobhan, additional, Wagstaff, Lynda, additional, Farrier, Adam, additional, Bisnauthsing, Karen, additional, Serafimova, Teona, additional, Nanino, Elisa, additional, Cooney, Enya, additional, Wilson-Goldsmith, Jaimie, additional, Nguyen, Hanna, additional, Mazzella, Andrea, additional, Jackson, Beth, additional, Aslam, Suahil, additional, Bawa, Tanveer, additional, Broadhead, Samantha, additional, Farooqi, Sadaf, additional, Piper, Jo, additional, Weighell, Rowena, additional, Pickup, Lorinda, additional, Shamtally, Djamila, additional, Domingo, Jason, additional, Kourampa, Evgenia, additional, Hale, Colin, additional, Gibney, Jennifer, additional, Stackpoole, Michael, additional, Rashid-Gardner, Zalina, additional, Lyon, Rebecca, additional, McDonnell, Chloe, additional, Cole, Christine, additional, Stewart, Anna, additional, McMillan, Gillian, additional, Savage, Mary, additional, Beckett, Helen, additional, Moorbey, Chantelle, additional, Desai, Amisha, additional, Brown, Claire, additional, Naker, Kush, additional, Qureshi, Ehsaan, additional, Trinham, Charlotte, additional, Sabine, Charlotte, additional, Moore, Sophie, additional, Hurdover, Steve, additional, Justice, Edwin, additional, Smith, David, additional, Plested, Emma, additional, Ferreira Da Silva, Carla, additional, White, Rachel, additional, Robinson, Hannah, additional, Cifuentes, Liliana, additional, Morshead, Gertraud, additional, Drake-Brockman, Rachael, additional, Kinch, Patrick, additional, Kasanyinga, Mwila, additional, Clutterbuck, Elizabeth A., additional, Bibi, Sagida, additional, Stuart, Arabella SV, additional, Shaw, Robert H, additional, Singh, Michael, additional, Champaneri, Trishna, additional, Irwin, Margaret, additional, Khan, Mohammed, additional, Kownacka, Alicja, additional, Nabunjo, Martha, additional, Osuji, Carool, additional, Hladkiwskyj, John, additional, Galvin, Dominic, additional, Patel, Gita, additional, Mouland, Johanna, additional, Longhurst, Beverley, additional, Moon, Maria, additional, Giddins, Beth, additional, Pereira Dias Alves, Carlota, additional, Richmond, Leah, additional, Minnis, Christine, additional, Baryschpolec, Sonia, additional, Elliott, Scott, additional, Fox, Lauren, additional, Graham, Victoria, additional, Baker, Natalie, additional, Godwin, Kerry, additional, Buttigieg, Karren, additional, Knight, Chanice, additional, Brown, Phillip, additional, Lall, Paminder, additional, Shaik, Imam, additional, Chiplin, Emily, additional, Brunt, Emily, additional, Leung, Stephanie, additional, Allen, Lauren, additional, Thomas, Steve, additional, Fraser, Sara, additional, Choi, Bea, additional, Gouriet, Jade, additional, Freedman, Andrew, additional, Perkins, Jonathan, additional, Gowland, Andrew, additional, Macdonald, Jonathan, additional, Seenan, John Paul, additional, Starinskij, Igor, additional, Seaton, Andrew, additional, Peters, Erica, additional, Singh, Stephen, additional, Gardside, Ben, additional, Bonnaud, Avril, additional, Davies, Ceri, additional, Gordon, Elizabeth, additional, Keenan, Samantha, additional, Hall, Jane, additional, Wilkins, Suzanne, additional, Tasker, Suzanne, additional, James, Rob, additional, Seath, Ingrid, additional, Littlewood, Kelly, additional, Newman, Joseph, additional, Boubriak, Iryna, additional, Suggitt, Debbie, additional, Haydock, Helen, additional, Bennett, Sara, additional, Woodyatt, Wiesia, additional, Hughes, Kerry, additional, Bell, Judith, additional, Coughlan, Tricia, additional, van Welsenes, Donald, additional, Kamal, Mohammed, additional, Cooper, Chris, additional, Tunstall, Simon, additional, Ronan, Nicholas, additional, Cutts, Rebecca, additional, Dare, Tracey, additional, Yim, Yee Ting Nicole, additional, Whittley, Sarah, additional, Ricamara, Marivic, additional, Hamal, Shama, additional, Adams, Kirsty, additional, Baker, Holly, additional, Driver, Kimberley, additional, Turner, Nicola, additional, Rawlins, Todd, additional, Roy, Subarna, additional, Merida-Morillas, Marta, additional, Sakagami, Yukari, additional, Andrews, Antonette, additional, Goncalves cordeiro, Lillian, additional, Stokes, Matthew, additional, Ambihapathy, Wythehi, additional, Spencer, Joanne, additional, Parungao, Nina, additional, Berry, Lisa, additional, Cullinane, James, additional, Presland, Laura, additional, Ross-Russell, Amy, additional, Warren, Sarah, additional, Baker, Jonathan, additional, Oliver, Abigail, additional, Buadi, Amanda, additional, Lee, Kim, additional, Haskell, Louise, additional, Romani, Rossana, additional, Bentley, Ian, additional, Whitbred, Tim, additional, Fowler, Simon, additional, Gavin, John, additional, Magee, Alan, additional, Watson, Tara, additional, Nightingale, Kari, additional, Marius, Phedra, additional, Summerton, Eloise, additional, Locke, Emily, additional, Honey, Thomas, additional, Lingwood, Aidan, additional, de la Haye, Anastasia, additional, Elliott, Ryan Stephen, additional, Underwood, Karen, additional, King, Mikayala, additional, Davies-Dear, Sharon, additional, Horsfall, Emily, additional, Chalwin, Olivia, additional, Burton, Holly, additional, Edwards, Christopher J, additional, Welham, Benjamin, additional, Garrahy, Sarah, additional, Hall, Fran, additional, Ladikou, Eleni, additional, Mullan, Dee, additional, Hansen, Daniel, additional, Campbell, Marion, additional, Dos Santos, Filipa, additional, Habash-Bailey, Haniah, additional, Lakeman, Nicki, additional, Branney, Debbie, additional, Vamplew, Luke, additional, Hogan, Alison, additional, Frankham, Jorden, additional, Wiselka, Martin, additional, Vail, Dennyl, additional, Wenn, Victoria, additional, Renals, Valerie, additional, Ellis, Kate, additional, Lewis-Taylor, Jessica, additional, Magan, Javier, additional, Hardy, Anna, additional, and Appleby, Kim, additional

Published
2021
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39. Development of a Hamster Natural Transmission Model of SARS-CoV-2 Infection

Author

Dowall, Stuart, primary, Salguero, Francisco J., additional, Wiblin, Nathan, additional, Fotheringham, Susan, additional, Hatch, Graham, additional, Parks, Simon, additional, Gowan, Kathryn, additional, Harris, Debbie, additional, Carnell, Oliver, additional, Fell, Rachel, additional, Watson, Robert, additional, Graham, Victoria, additional, Gooch, Karen, additional, Hall, Yper, additional, Mizen, Simon, additional, and Hewson, Roger, additional

Published
2021
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41. Selecting a corporate payment system

Author

DeLuna, JoAnn, Wagonlit, Carlson, Cornelius, Clive, Hunt, Michelle, Wakida, Rick, and Graham, Victoria

Subjects
Business, Human resources and labor relations, Business, international, Travel industry
Abstract

CAPTURING SPEND DATA, MATCHING IT WITH TRAVEL MANAGEMENT COMPANY booking data and integrating it with automated expense management systems allow travel managers to compare booked versus actual spend. With greater [...]

Published
2015

44. The African Small Island Developing States and normative coherence for sustainable development: The quality of civil rights and liberties.

Author

Graham, Victoria and Graham, Suzanne

Subjects
*CIVIL rights, *SUSTAINABLE development, *SMALL states, *REGIONAL development, *ISLANDS
Abstract

Summary: Motivation: The literature on small states suggests that small island states are more likely than larger states to support regional and international democratic norms, but is this true of the six African Small Island Developing States (ASIDS), an underexplored regional grouping? This article explores the ASIDS' normative commitment to regional democratic norms of civil rights and liberties. Purpose: This article aims to answer the question: how normatively coherent are ASIDS with the normative development of regional civil rights and liberty norms promoted by the African Union (AU) through the Banjul Charter? Methods and approach: The article adopts a normative conceptual lens in its outlook and uses quality of democracy methodology to compare the quality of selected regional civil rights and liberty norms across the ASIDS grouping. Findings The article finds that procedurally all ASIDS are coherent with the Banjul Charter norms on civil rights and liberties, but that local realities mean that substantive coherence to these norms is often slow or, in some cases, ineffectual. Cultural context, agency, and capacity are as important as size and "islandness" in determining small island state democratic quality. Policy implications: It suggests that political will for normative coherence for sustainable development (NCSD) within a region is not enough, at least for these island states. A real lack of capacity warrants greater regional support from continental Africa in the form of, among other things, financing, capacity building, expertise, peer review, and monitoring. Only through reinforcement of NCSD can the AU fulfil its rights‐based mission. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Changes in regulation of sodium/calcium exchanger of avian ventricular heart cells during embryonic development

Author

Shepherd, Neal, Graham, Victoria, Trevedi, Bhavya, and Creazzo, Tony L.

Subjects
Heart cells -- Research, Heart cells -- Physiological aspects, Cellular control mechanisms -- Research, Cell research, Biological sciences
Abstract

It has been suggested that the sodium/calcium exchanger NCX1 may have a more important physiological role in embryonic and neonatal hearts than in adult hearts. However, in chick heart sarcolemmal vesicles, sodium-dependent calcium transport is reported to be small and, moreover, to be 3-12 times smaller in hearts at embryonic day (ED) 4-5 than at ED18, the opposite of what would be expected of a transporter that is more important in early development. To better assess the role of NCX1 in calcium regulation in the chick embryonic heart, we measured the activity of NCXI in chick embryonic hearts as extracellular calcium-activated exchanger current ([I.sub.NCX]) under controlled ionic conditions. With intracellular calcium concentration ([[[Ca.sup.2+]].sub.i]) = 47 nM, [I.sub.NCX] density increased from 1.34 [+ or -] 0.28 pA/pF at ED2 to 3.22 [+ or -] 0.55 pA/pF at ED11 (P = 0.006); however, with [[[Ca.sup.2+]].sub.i] = 481 nM, the increase was small and statistically insignificant, from 4.54 [+ or -] 0.77 to 5.88 [+ or -] 0.73 pA/pF (P = 0.20, membrane potential = 0 mV, extracellular calcium concentration = 2 mM). Plots of [I.sub.NCX] density against [[[Ca.sup.2+]].sub.i] were well fitted by the Michaelis-Menton equation and extrapolated to identical maximal currents for ED2 and ED11 cells (extracellular calcium concentration = 1, 2, or 4 mM). Thus the increase in [I.sub.NCX] at low [[[Ca.sup.2+]].sub.i] appeared to reflect a developmental change in allosteric regulation of the exchanger by intracellular calcium rather than an increase in the membrane density of NCX1. Supporting this conclusion, RT-PCR demonstrated little change in the amount of mRNA encoding NCX1 expression from ED2 through ED18. NCX1; chick embryo; allosteric regulation; sodium/calcium exchange current doi:10.1152/ajpcell.00564.2006

Published
2007

48. Exportation of Monkeypox Virus From the African Continent.

Author

Mauldin, Matthew R, McCollum, Andrea M, Nakazawa, Yoshinori J, Mandra, Anna, Whitehouse, Erin R, Davidson, Whitni, Zhao, Hui, Gao, Jinxin, Li, Yu, Doty, Jeffrey, Yinka-Ogunleye, Adesola, Akinpelu, Afolabi, Aruna, Olusola, Naidoo, Dhamari, Lewandowski, Kuiama, Afrough, Babak, Graham, Victoria, Aarons, Emma, Hewson, Roger, and Vipond, Richard

Subjects
VIRUSES, EPIDEMICS, RESEARCH funding
Abstract

Background: The largest West African monkeypox outbreak began September 2017, in Nigeria. Four individuals traveling from Nigeria to the United Kingdom (n = 2), Israel (n = 1), and Singapore (n = 1) became the first human monkeypox cases exported from Africa, and a related nosocomial transmission event in the United Kingdom became the first confirmed human-to-human monkeypox transmission event outside of Africa.Methods: Epidemiological and molecular data for exported and Nigerian cases were analyzed jointly to better understand the exportations in the temporal and geographic context of the outbreak.Results: Isolates from all travelers and a Bayelsa case shared a most recent common ancestor and traveled to Bayelsa, Delta, or Rivers states. Genetic variation for this cluster was lower than would be expected from a random sampling of genomes from this outbreak, but data did not support direct links between travelers.Conclusions: Monophyly of exportation cases and the Bayelsa sample, along with the intermediate levels of genetic variation, suggest a small pool of related isolates is the likely source for the exported infections. This may be the result of the level of genetic variation present in monkeypox isolates circulating within the contiguous region of Bayelsa, Delta, and Rivers states, or another more restricted, yet unidentified source pool. [ABSTRACT FROM AUTHOR]

Published
2022
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