353 results on '"Graf, Urs"'
Search Results
2. Holographic surface measurement system for the Fred Young Submillimeter Telescope
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Ren, Xiaodong, Astudillo, Pablo, Graf, Urs U., Hills, Richard E., Jorquera, Sebastian, Nikolic, Bojan, Parshley, Stephen C., Reyes, Nicolás, and Weikert, Lars
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Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Optics - Abstract
We describe a system being developed for measuring the shapes of the mirrors of the Fred Young Submillimeter Telescope (FYST), now under construction for the CCAT Observatory. "Holographic" antenna-measuring techniques are an efficient and accurate way of measuring the surfaces of large millimeter-wave telescopes and they have the advantage of measuring the wave-front errors of the whole system under operational conditions, e.g. at night on an exposed site. Applying this to FYST, however, presents significant challenges because of the high accuracy needed, the fact that the telescope consists of two large off-axis mirrors, and a requirement that measurements can be made without personnel present. We use a high-frequency (~300GHz) source which is relatively close to the telescope aperture (<1/100th of the Fresnel distance) to minimize atmospheric effects. The main receiver is in the receiver cabin and can be moved under remote control to different positions, so that the wave-front errors in different parts of the focal plane can be measured. A second receiver placed on the yoke provides a phase reference. The signals are combined in a digital cross-correlation spectrometer. Scanning the telescope provides a map of the complex beam pattern. The surface errors are found by inference, i.e. we make models of the reflectors with errors and calculate the patterns expected, and then iterate to find the best match to the data. To do this we have developed a fast and accurate method for calculating the patterns using the Kirchhoff-Fresnel formulation. This paper presents details of the design and outlines the results from simulations of the measurement and inference process. These indicate that a measurement accuracy of ~3 microns rms is achievable., Comment: Proceedings Volume 11445, Ground-based and Airborne Telescopes VIII SPIE Astronomical Telescopes + Instrumentation, 2020, Online Only Conference
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- 2021
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3. 4GREAT -- a four-color receiver for high-resolution airborne terahertz spectroscopy
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Durán, Carlos A., Güsten, Rolf, Risacher, Christophe, Görlitz, Andrej, Klein, Bernd, Reyes, Nicolas, Ricken, Oliver, Wunsch, Hans-Joachim, Graf, Urs U., Jacobs, Karl, Honingh, Cornelia E., Stutzki, Jürgen, de Lange, Gert, Delorme, Yan, Krieg, Jean-Michel, and Lis, Dariusz C.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
4GREAT is an extension of the German Receiver for Astronomy at Terahertz frequencies (GREAT) operated aboard the Stratospheric Observatory for Infrared Astronomy (SOFIA). The spectrometer comprises four different detector bands and their associated subsystems for simultaneous and fully independent science operation. All detector beams are co-aligned on the sky. The frequency bands of 4GREAT cover 491-635, 890-1090, 1240-1525 and 2490-2590 GHz, respectively. This paper presents the design and characterization of the instrument, and its in-flight performance. 4GREAT saw first light in June 2018, and has been offered to the interested SOFIA communities starting with observing cycle 6., Comment: Accepted for publication in IEEE Transactions on Terahertz Science and Technology
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- 2020
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4. The CCAT-Prime Submillimeter Observatory
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Aravena, Manuel, Austermann, Jason, Basu, Kaustuv, Battaglia, Nicholas, Beringue, Benjamin, Bertoldi, Frank, Bond, J. Richard, Breysse, Patrick, Bustos, Ricardo, Chapman, Scott, Choi, Steve, Chung, Dongwoo, Cothard, Nicholas, Dober, Bradley, Duell, Cody, Duff, Shannon, Dunner, Rolando, Erler, Jens, Fich, Michel, Fissel, Laura, Foreman, Simon, Gallardo, Patricio, Gao, Jiansong, Giovanelli, Riccardo, Graf, Urs, Haynes, Martha, Herter, Terry, Hilton, Gene, Hlozek, Renee, Hubmayr, Johannes, Johnstone, Doug, Keating, Laura, Komatsu, Eiichiro, Magnelli, Benjamin, Mauskopf, Phil, McMahon, Jeffrey, Meerburg, P. Daniel, Meyers, Joel, Murray, Norm, Niemack, Michael, Nikola, Thomas, Nolta, Michael, Parshley, Stephen, Puddu, Roberto, Riechers, Dominik, Rosolowsky, Erik, Simon, Sara, Stacey, Gordon, Stevens, Jason, Stutzki, Juergen, Van Engelen, Alexander, Vavagiakis, Eve, Viero, Marco, Vissers, Michael, Walker, Samantha, and Zou, Bugao
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The Cerro Chajnantor Atacama Telescope-prime (CCAT-prime) is a new 6-m, off-axis, low-emissivity, large field-of-view submillimeter telescope scheduled for first light in the last quarter of 2021. In summary, (a) CCAT-prime uniquely combines a large field-of-view (up to 8-deg), low emissivity telescope (< 2%) and excellent atmospheric transmission (5600-m site) to achieve unprecedented survey capability in the submillimeter. (b) Over five years, CCAT-prime first generation science will address the physics of star formation, galaxy evolution, and galaxy cluster formation; probe the re-ionization of the Universe; improve constraints on new particle species; and provide for improved removal of dust foregrounds to aid the search for primordial gravitational waves. (c) The Observatory is being built with non-federal funds (~ \$40M in private and international investments). Public funding is needed for instrumentation (~ \$8M) and operations (\$1-2M/yr). In return, the community will be able to participate in survey planning and gain access to curated data sets. (d) For second generation science, CCAT-prime will be uniquely positioned to contribute high-frequency capabilities to the next generation of CMB surveys in partnership with the CMB-S4 and/or the Simons Observatory projects or revolutionize wide-field, sub-millimetter line intensity mapping surveys., Comment: Astro2020 APC White Paper
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- 2019
5. First Generation Heterodyne Instrumentation Concepts for the Atacama Large Aperture Submillimeter Telescope
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Groppi, Christopher, Baryshev, Andrey, Graf, Urs, Wiedner, Martina, Klaassen, Pamela, and Mroczkowski, Tony
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
(abridged) The Atacama Large Aperture Submillimeter Telescope (AtLAST) project aims to build a 50-m-class submm telescope with $>1^\circ$ field of view, high in the Atacama Desert, providing fast and detailed mapping of the mm/submm sky. It will thus serve as a strong complement to existing facilities such as ALMA. ALMA's small field of view ($<15^{\prime\prime}$ at 350 GHz) limits its mapping speed for large surveys. Instead, a single dish with a large field of view such as the AtLAST concept can host large multi-element instruments that can more efficiently map large portions of the sky. Small aperture survey instruments (typically much smaller than $<3\times$ the size of an interferometric array element) can mitigate this somewhat but lack the resolution for accurate recovery of source location and have small collecting areas. Furthermore, small aperture survey instruments do not provide sufficient overlap in the spatial scales they sample to provide a complete reconstruction of extended sources (i.e.\ the zero-spacing information is incomplete in $u,v$-space.) The heterodyne instrumentation for the AtLAST telescope that we consider here will take advantage of extensive developments in the past decade improving the performance and pixel count of heterodyne focal plane arrays. Such instrumentation, with higher pixel counts, has alredy begun to take advantage of integration in the focal planes to increase packaging efficiency over simply stacking modular mixer blocks in the focal plane. We extrapolate from the current state-of-the-art to present concept first-generation heterodyne designs for AtLAST., Comment: to be published in the proceedings of the 30th International Symposium on Space Terahertz Technology (https://www.isstt2019.com/). Final version will appear when the link to the 30th annual proceedings becomes active: https://www.nrao.edu/meetings/isstt/tocs.shtml
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- 2019
6. First astrophysical detection of the helium hydride ion (HeH$^+$)
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Güsten, Rolf, Wiesemeyer, Helmut, Neufeld, David, Menten, Karl M., Graf, Urs U., Jacobs, Karl, Klein, Bernd, Ricken, Oliver, Risacher, Christophe, and Stutzki, Jürgen
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
During the dawn of chemistry when the temperature of the young Universe had fallen below $\sim$4000 K, the ions of the light elements produced in Big Bang nucleosynthesis recombined in reverse order of their ionization potential. With its higher ionization potentials, He$^{++}$ (54.5 eV) and He$^+$ (24.6 eV) combined first with free electrons to form the first neutral atom, prior to the recombination of hydrogen (13.6 eV). At that time, in this metal-free and low-density environment, neutral helium atoms formed the Universe's first molecular bond in the helium hydride ion HeH$^+$, by radiative association with protons (He + H$^+$ $\rightarrow$ HeH$^+$ + h$\nu$). As recombination progressed, the destruction of HeH$^+$ (HeH$^+$ + H $\rightarrow$ He + H$_2^+$) created a first path to the formation of molecular hydrogen, marking the beginning of the Molecular Age. Despite its unquestioned importance for the evolution of the early Universe, the HeH$^+$ molecule has so far escaped unequivocal detection in interstellar space. In the laboratory, the ion was discovered as long ago as 1925, but only in the late seventies was the possibility that HeH$^+$ might exist in local astrophysical plasmas discussed. In particular, the conditions in planetary nebulae were shown to be suitable for the production of potentially detectable HeH$^+$ column densities: the hard radiation field from the central hot white dwarf creates overlapping Str\"omgren spheres, where HeH$^+$ is predicted to form, primarily by radiative association of He$^+$ and H. With the GREAT spectrometer onboard SOFIA, the HeH$^+$ rotational ground-state transition at $\lambda$149.1 $\mu$m is now accessible. We report here its detection towards the planetary nebula NGC7027., Comment: 3 figures, 2 tables
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- 2019
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7. Velocity profiles of [CII], [CI], CO, and [OI] and physical conditions in four star-forming regions in the Large Magellanic Cloud
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Okada, Yoko, Güsten, Rolf, Requena-Torres, Miguel Angel, Röllig, Markus, Stutzki, Jürgen, Graf, Urs U., and Hughes, Annie
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Astrophysics - Astrophysics of Galaxies - Abstract
The aim of our study is to investigate the physical properties of the star-forming interstellar medium (ISM) in the Large Magellanic Cloud (LMC) by separating the origin of the emission lines spatially and spectrally. Following Okada et al. (2015, Paper I), we investigate different phases of the ISM traced by carbon-bearing species in four star-forming regions in the LMC, and model the physical properties using the KOSMA-tau PDR model. We mapped 3--13 arcmin$^2$ areas in 30 Dor, N158, N160 and N159 along the molecular ridge of the LMC in [CII]158um with GREAT on board SOFIA, and in CO(2-1) to (6-5), $^{13}$CO(2-1) and (3-2), [CI]3P1-3P0 and 3P2-3P1 with APEX. In all four star-forming regions, the line profiles of CO, $^{13}$CO, and [CI] emission are similar, whereas [CII] typically shows wider line profiles or an additional velocity component. For selected positions in N159 and 30 Dor, we observed the velocity-resolved [OI] 145um and 63um lines for the first time with upGREAT. At some positions, the [OI] line profiles match those of CO, at other positions they are more similar to the [CII] profiles. We interpret the different line profiles of CO, [CII] and [OI] as contributions from spatially separated clouds and/or clouds in different physical phases, which give different line ratios depending on their physical properties. We model the emission from the CO, [CI], [CII], and [OI] lines and the far-infrared continuum emission using the latest KOSMA-tau PDR model, which treats the dust-related physics consistently and computes the dust continuum SED together with the line emission of the chemical species. We find that the line and continuum emissions are not well-reproduced by a single clump ensemble. Toward the CO peak at N159~W, we propose a scenario that the CO, [CII], and [OI] 63um emission are weaker than expected because of mutual shielding among clumps. (abridged for arXiv), Comment: 27 pages with 26 figures, accepted for publication in A&A
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- 2018
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8. CCAT-prime: a novel telescope for submillimeter astronomy
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Parshley, Stephen C., Kronshage, Jörg, Blair, James, Herter, Terry, Nolta, Mike, Stacey, Gordon J., Bazarko, Andrew, Bertoldi, Frank, Bustos, Ricardo, Campbell, Donald B., Chapman, Scott, Cothard, Nicholas, Devlin, Mark, Erler, Jens, Fich, Michel, Gallardo, Patricio A., Giovanelli, Riccardo, Graf, Urs, Gramke, Scott, Haynes, Martha P., Hills, Richard, Limon, Michele, Mangum, Jeffrey G., McMahon, Jeff, Niemack, Michael D., Nikola, Thomas, Omlor, Markus, Riechers, Dominik A., Steeger, Karl, Stutzki, Jürgen, and Vavagiakis, Eve M.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The CCAT-prime telescope is a 6-meter aperture, crossed-Dragone telescope, designed for millimeter and sub-millimeter wavelength observations. It will be located at an altitude of 5600 meters, just below the summit of Cerro Chajnantor in the high Atacama region of Chile. The telescope's unobscured optics deliver a field of view of almost 8 degrees over a large, flat focal plane, enabling it to accommodate current and future instrumentation fielding >100k diffraction-limited beams for wavelengths less than a millimeter. The mount is a novel design with the aluminum-tiled mirrors nested inside the telescope structure. The elevation housing has an integrated shutter that can enclose the mirrors, protecting them from inclement weather. The telescope is designed to co-host multiple instruments over its nominal 15 year lifetime. It will be operated remotely, requiring minimum maintenance and on-site activities due to the harsh working conditions on the mountain. The design utilizes nickel-iron alloy (Invar) and carbon-fiber-reinforced polymer (CFRP) materials in the mirror support structure, achieving a relatively temperature-insensitive mount. We discuss requirements, specifications, critical design elements, and the expected performance of the CCAT-prime telescope. The telescope is being built by CCAT Observatory, Inc., a corporation formed by an international partnership of universities. More information about CCAT and the CCAT-prime telescope can be found at www.ccatobservatory.org., Comment: Event: SPIE Astronomical Telescope + Instrumentation, 2018, Austin, Texas, USA; Proceedings Volume 10700, Ground-based and Airborne Telescopes VII; 107005X (2018)
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- 2018
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9. 100 GHz Room-Temperature Laboratory Emission Spectrometer
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Wehres, Nadine, Heyne, Bettina, Lewen, Frank, Hermanns, Marius, Schmidt, Bernhard, Endres, Christian, Graf, Urs U., Higgins, Daniel R., and Schlemmer, Stephan
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present first results of a new heterodyne spectrometer dedicated to high-resolution spectroscopy of molecules of astrophysical importance. The spectrometer, based on a roomtemperature heterodyne receiver, is sensitive to frequencies between 75 and 110 GHz with an instantaneous bandwidth of currently 2.5 GHz in a single sideband. The system performance, in particular the sensitivity and stability, is evaluated. Proof of concept of this spectrometer is demonstrated by recording the emission spectrum of methyl cyanide, CH3CN. Compared to state-of-the-art radio telescope receivers the instrument is less sensitive by about one order of magnitude. Nevertheless, the capability for absolute intensity measurements can be exploited in various experiments, in particular for the interpretation of the ever richer spectra in the ALMA era. The ease of operation at room-temperature allows for long time integration, the fast response time for integration in chirped pulse instruments or for recording time dependent signals. Future prospects as well as limitations of the receiver for the spectroscopy of complex organic molecules (COMs) are discussed., Comment: 14 pages, 7 figures, IAUS-332 Astrochemistry VII, Through the Cosmos from Galaxies to Planets, 2017
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- 2018
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10. Benefits and outcomes of a new multidisciplinary approach for the management and financing of sudden unexplained death cases in a forensic setting in Switzerland
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Neubauer, Jacqueline, Kissel, Christine K., Bolliger, Stephan A., Barbon, Daniela, Thali, Michael J., Kloiber, Daniel, Bode, Peter K., Kovacs, Boldizsar, Graf, Urs, Maspoli, Alessandro, Berger, Wolfgang, Saguner, Ardan M., and Haas, Cordula
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- 2022
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11. Macular Corneal Dystrophy – Molecular Genetics as the Key in Treatment-Refractory Keratopathy
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Spindler, Jan, additional, Koller, Samuel, additional, Graf, Urs, additional, Berger, Wolfgang, additional, Gerth-Kahlert, Christina, additional, and Blaser, Frank, additional
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- 2024
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12. Disentangling the ISM phases of the dwarf galaxy NGC 4214 using [CII] SOFIA/GREAT observations
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Fahrion, Katja, Cormier, Diane, Bigiel, Frank, Hony, Sacha, Abel, Nick P., Cigan, Phil, Csengeri, Timea, Graf, Urs, Lebouteiller, Vianney, Madden, Suzanne C., Wu, Ronin, and Young, Lisa
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Astrophysics - Astrophysics of Galaxies - Abstract
The [CII] 158 um fine structure line is one of the dominant cooling lines in the interstellar medium (ISM) and is an important tracer of star formation. Recent velocity-resolved studies with Herschel/HIFI and SOFIA/GREAT showed that the [CII] line can constrain the properties of the ISM phases in star-forming regions. The [CII] line as a tracer of star formation is particularly important in low-metallicity environments where CO emission is weak because of the presence of large amounts of CO-dark gas. The nearby irregular dwarf galaxy NGC 4214 offers an excellent opportunity to study an actively star-forming ISM at low metallicity. We analyzed the spectrally resolved [CII] line profiles in three distinct regions at different evolutionary stages of NGC 4214 with respect to ancillary HI and CO data in order to study the origin of the [CII] line. We used SOFIA/GREAT [CII] 158 um observations, HI data from THINGS, and CO(2-1) data from HERACLES to decompose the spectrally resolved [CII] line profiles into components associated with neutral atomic and molecular gas. We use this decomposition to infer gas masses traced by [CII] under different ISM conditions. Averaged over all regions, we associate about 46% of the [CII] emission with the HI emission. However, we can assign only around 9% of the total [CII] emission to the cold neutral medium (CNM). We found that about 79% of the total molecular hydrogen mass is not traced by CO emission. On average, the fraction of CO-dark gas dominates the molecular gas mass budget. The fraction seems to depend on the evolutionary stage of the regions: it is highest in the region covering a super star cluster in NGC 4214, while it is lower in a more compact, more metal-rich region., Comment: 13 pages, 6 figures, accepted for publication in A and A
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- 2016
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13. First supra-THz Heterodyne Array Receivers for Astronomy with the SOFIA Observatory
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Risacher, Christophe, Guesten, Rolf, Stutzki, Juergen, Huebers, Heinz-Wilhelm, Buechel, Denis, Graf, Urs U., Heyminck, Stefan, Honingh, Cornelia E., Jacobs, Karl, Klein, Bernd, Klein, Thomas, Leinz, Christian, Puetz, Patrick, Reyes, Nicolas, Ricken, Oliver, Wunsch, Hans-Joachim, Fusco, Paul, and Rosner, Stefan
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present the upGREAT THz heterodyne arrays for far-infrared astronomy. The Low Frequency Array (LFA) is designed to cover the 1.9-2.5 THz range using 2x7-pixel waveguide-based HEB mixer arrays in a dual polarization configuration. The High Frequency Array (HFA) will perform observations of the [OI] line at ~4.745 THz using a 7-pixel waveguide-based HEB mixer array. This paper describes the common design for both arrays, cooled to 4.5 K using closed- cycle pulse tube technology. We then show the laboratory and telescope characterization of the first array with its 14 pixels (LFA), which culminated in the successful commissioning in May 2015 aboard the SOFIA airborne observatory observing the [CII] fine structure transition at 1.905 THz. This is the first successful demonstration of astronomical observations with a heterodyne focal plane array above 1 THz and is also the first time high- power closed-cycle coolers for temperatures below 4.5 K are operated on an airborne platform., Comment: accepted for publication in IEEE Transactions on Terahertz Science and Technology
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- 2015
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14. Bringing high spatial resolution to the far-infrared: A giant leap for astrophysics
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Linz, Hendrik, Beuther, Henrik, Gerin, Maryvonne, Goicoechea, Javier R., Helmich, Frank, Krause, Oliver, Liu, Yao, Molinari, Sergio, Ossenkopf-Okada, Volker, Pineda, Jorge, Sauvage, Marc, Schinnerer, Eva, van der Tak, Floris, Wiedner, Martina, Amiaux, Jerome, Bhatia, Divya, Buinhas, Luisa, Durand, Gilles, Förstner, Roger, Graf, Urs, and Lezius, Matthias
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- 2021
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15. Impacts of pure shocks in the BHR71 bipolar outflow
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Gusdorf, Antoine, Riquelme, Denise, Anderl, Sibylle, Eisloeffel, Jochen, Codella, Claudio, Gomez-Ruiz, Arturo, Graf, Urs, Kristensen, Lars, Leurini, Silvia, Parise, Berengere, Requena-Torres, Migel, Ricken, Oliver, and Guesten, Rolf
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Astrophysics - Astrophysics of Galaxies - Abstract
During the formation of a star, material is ejected along powerful jets that impact the ambient material. This outflow regulates star formation by e.g. inducing turbulence and heating the surrounding gas. Understanding the associated shocks is therefore essential to the study of star formation. We present comparisons of shock models with CO, H2, and SiO observations in a 'pure' shock position in the BHR71 bipolar outflow. These comparisons provide an insight into the shock and pre-shock characteristics, and allow us to understand the energetic and chemical feedback of star formation on Galactic scales. New CO (Jup = 16, 11, 7, 6, 4, 3) observations from the shocked regions with the SOFIA and APEX telescopes are presented and combined with earlier H2 and SiO data (from the Spitzer and APEX telescopes). The integrated intensities are compared to a grid of models that were obtained from a magneto-hydrodynamical shock code which calculates the dynamical and chemical structure of these regions combined with a radiative transfer module based on the 'large velocity gradient' approximation. The CO emission leads us to update the conclusions of our previous shock analysis: pre-shock densities of 1e4 cm-3 and shock velocities around 20-25 km s-1 are still constrained, but older ages are inferred ( 4000 years). We evaluate the contribution of shocks to the excitation of CO around forming stars. The SiO observations are compatible with a scenario where less than 4% of the pre-shock SiO belongs to the grain mantles. We infer outflow parameters: a mass of 1.8x1e-2 Msun was measured in our beam, in which a momentum of 0.4 Msun km s-1 is dissipated, for an energy of 4.2x1e43erg. We analyse the energetics of the outflow species by species. Comparing our results with previous studies highlights their dependence on the method: H2 observations only are not sufficient to evaluate the mass of outflows., Comment: 14 pages, 10 figures, 4 Tables, accepted in A&A
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- 2015
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16. GREAT [CII] and CO observations of the BD+40{\deg}4124 region
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Sandell, Göran, Wiesemeyer, Helmut, Requena-Torres, Miguel Angel, Heyminck, Stefan, Güsten, Rolf, Stutzki, Jürgen, Simon, Robert, and Graf, Urs U.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Galaxy Astrophysics - Abstract
The BD+40\degree4124 region was observed with high angular and spectral resolution with the German heterodyne instrument GREAT in CO J = 13 \rightarrow 12 and [CII] on SOFIA. These observations show that the [CII] emission is very strong in the reflection nebula surrounding the young Herbig Ae/Be star BD+40\degree4124. A strip map over the nebula shows that the [CII] emission approximately coincides with the optical nebulosity. The strongest [CII] emission is centered on the B2 star and a deep spectrum shows that it has faint wings, which suggests that the ionized gas is expanding. We also see faint CO J = 13 \rightarrow 12 at the position of BD+40\degree4124, which suggests that the star may still be surrounded by an accretion disk.We also detected [CII] emission and strong CO J = 13 \rightarrow 12 toward V1318 Cyg. Here the [CII] emission is fainter than in BD+40\degree4124 and appears to come from the outflow, since it shows red and blue wings with very little emission at the systemic velocity, where the CO emission is quite strong. It therefore appears that in the broad ISO beam the [CII] emission was dominated by the reflection nebula surrounding BD+40\degree4124, while the high J CO lines originated from the adjacent younger and more deeply embedded binary system V1318 Cyg.
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- 2012
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17. SOFIA observations of S106: Dynamics of the warm gas
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Simon, Robert, Schneider, Nicola, Stutzki, Juergen, Guesten, Rolf, Graf, Urs, Hartogh, Paul, Guan, Xin, Staguhn, Johannes, and Benford, Dominic
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Astrophysics - Astrophysics of Galaxies - Abstract
Context. The HII region/PDR/molecular cloud complex S106 is excited by a single O-star. The full extent of the warm and dense gas close to the star has not been mapped in spectrally resolved high-J CO or [CII] lines, so the kinematics of the warm, partially ionized gas, are unknown. Whether the prominent dark lane bisecting the hourglass-shaped nebula is due solely to the shadow cast by a small disk around the exciting star or also to extinction in high column foreground gas was an open question until now. Aims. To disentangle the morphology and kinematics of warm neutral and ionized gas close to the star, study their relation to the bulk of the molecular gas, and to investigate the nature of the dark lane. Methods. We use the heterodyne receiver GREAT on board SOFIA to observe velocity resolved spectral lines of [C II] and CO 11-10 in comparison with so far unpublished submm continuum data at 350 micron (SHARC-II) and complementary molecular line data. Results. The high angular and spectral resolution observations show a very complex morphology and kinematics of the inner S106 region, with many different components at different excitation conditions contributing to the observed emission. The [C II] lines are found to be bright and very broad, tracing high velocity gas close to the interface of molecular cloud and HII region. CO 11-10 emission is more confined, both spatially and in velocity, to the immediate surroundings of S106 IR showing the presence of warm, high density (clumpy) gas. Our high angular resolution submm continuum observations rule out the scenario where the dark lane separating the two lobes is due solely to the shadow cast by a small disk close to the star. The lane is clearly seen also as warm, high column density gas at the boundary of the molecular cloud and HII region., Comment: 4 pages plus 2 pages online appendix, 4 figures
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- 2012
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18. GREAT/SOFIA atmospheric calibration
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Guan, Xin, Stutzki, Jürgen, Graf, Urs U., Güsten, Rolf, Okada, Yoko, Torres, Miguel Angel Requena, Simon, Robert, and Wiesemeyer, Helmut
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The GREAT observations need frequency-selective calibration across the passband for the residual atmospheric opacity at flight altitude. At these altitudes the atmospheric opacity has both narrow and broad spectral features. To determine the atmospheric transmission at high spectral resolution, GREAT compares the observed atmospheric emission with atmospheric model predictions, and therefore depends on the validity of the atmospheric models. We discusse the problems identified in this comparison with respect to the observed data and the models, and describe the strategy used to calibrate the science data from GREAT/SOFIA during the first observing periods., Comment: 14 pages, 4 figures
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- 2012
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19. Frequency Stabilization of a 4.7 THz Quantum Cascade Laser Using a Delay Line Frequency Discriminator
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Mahdizadeh, Sajjad, primary, Graf, Urs U., additional, Justen, Matthias, additional, Faist, Jérôme, additional, Beck, Mattias, additional, Olariu, Tudor, additional, and Stutzki, Jürgen, additional
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- 2023
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20. Astrophysical detection of the helium hydride ion HeH+
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Güsten, Rolf, Wiesemeyer, Helmut, Neufeld, David, Menten, Karl M., Graf, Urs U., Jacobs, Karl, Klein, Bernd, Ricken, Oliver, Risacher, Christophe, and Stutzki, Jürgen
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- 2019
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21. The Spectrum of MORC2-Related Disorders:A Potential Link to Cockayne Syndrome
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Stafki, Seth A., Turner, Johnnie, Littel, Hannah R., Bruels, Christine C., Truong, Don, Knirsch, Ursula, Stettner, Georg M., Graf, Urs, Berger, Wolfgang, Kinali, Maria, Jungbluth, Heinz, Pacak, Christina A., Hughes, Jayne, Mirchi, Amytice, Derksen, Alexa, Vincent-Delorme, Catherine, Theil, Arjan F., Bernard, Geneviève, Ellis, David, Fassihi, Hiva, Lehmann, Alan R., Laugel, Vincent, Mohammed, Shehla, Kang, Peter B., Stafki, Seth A., Turner, Johnnie, Littel, Hannah R., Bruels, Christine C., Truong, Don, Knirsch, Ursula, Stettner, Georg M., Graf, Urs, Berger, Wolfgang, Kinali, Maria, Jungbluth, Heinz, Pacak, Christina A., Hughes, Jayne, Mirchi, Amytice, Derksen, Alexa, Vincent-Delorme, Catherine, Theil, Arjan F., Bernard, Geneviève, Ellis, David, Fassihi, Hiva, Lehmann, Alan R., Laugel, Vincent, Mohammed, Shehla, and Kang, Peter B.
- Abstract
Background: Cockayne syndrome (CS) is a DNA repair disorder primarily associated with pathogenic variants in ERCC6 and ERCC8. As in other Mendelian disorders, there are a number of genetically unsolved CS cases. Methods: We ascertained five individuals with monoallelic pathogenic variants in MORC2, previously associated with three dominantly inherited phenotypes: an axonal form of Charcot-Marie-Tooth disease type 2Z; a syndrome of developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy; and a rare form of spinal muscular atrophy. Results: One of these individuals bore a strong phenotypic resemblance to CS. We then identified monoallelic pathogenic MORC2 variants in three of five genetically unsolved individuals with a clinical diagnosis of CS. In total, we identified eight individuals with MORC2-related disorder, four of whom had clinical features strongly suggestive of CS. Conclusions: Our findings indicate that some forms of MORC2-related disorder have phenotypic similarities to CS, including features of accelerated aging. Unlike classic DNA repair disorders, MORC2-related disorder does not appear to be associated with a defect in transcription-coupled nucleotide excision repair and follows a dominant pattern of inheritance with variants typically arising de novo. Such de novo pathogenic variants present particular challenges with regard to both initial gene discovery and diagnostic evaluations. MORC2 should be included in diagnostic genetic test panels targeting the evaluation of microcephaly and/or suspected DNA repair disorders. Future studies of MORC2 and its protein product, coupled with further phenotypic characterization, will help to optimize the diagnosis, understanding, and therapy of the associated disorders.
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- 2023
22. The Spectrum of MORC2-Related Disorders: A Potential Link to Cockayne Syndrome
- Author
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Stafki, Seth A, Turner, Johnnie, Littel, Hannah R, Bruels, Christine C, Truong, Don, Knirsch, Ursula, Stettner, Georg M, Graf, Urs, Berger, Wolfgang, Kinali, Maria, Jungbluth, Heinz, Pacak, Christina A, Hughes, Jayne, Mirchi, Amytice, Derksen, Alexa, Vincent-Delorme, Catherine, Theil, Arjan F, Bernard, Geneviève, Ellis, David, Fassihi, Hiva, Lehmann, Alan R, Laugel, Vincent, Mohammed, Shehla, Kang, Peter B, Stafki, Seth A, Turner, Johnnie, Littel, Hannah R, Bruels, Christine C, Truong, Don, Knirsch, Ursula, Stettner, Georg M, Graf, Urs, Berger, Wolfgang, Kinali, Maria, Jungbluth, Heinz, Pacak, Christina A, Hughes, Jayne, Mirchi, Amytice, Derksen, Alexa, Vincent-Delorme, Catherine, Theil, Arjan F, Bernard, Geneviève, Ellis, David, Fassihi, Hiva, Lehmann, Alan R, Laugel, Vincent, Mohammed, Shehla, and Kang, Peter B
- Abstract
BACKGROUND Cockayne syndrome (CS) is a DNA repair disorder primarily associated with pathogenic variants in ERCC6 and ERCC8. As in other Mendelian disorders, there are a number of genetically unsolved CS cases. METHODS We ascertained five individuals with monoallelic pathogenic variants in MORC2, previously associated with three dominantly inherited phenotypes: an axonal form of Charcot-Marie-Tooth disease type 2Z; a syndrome of developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy; and a rare form of spinal muscular atrophy. RESULTS One of these individuals bore a strong phenotypic resemblance to CS. We then identified monoallelic pathogenic MORC2 variants in three of five genetically unsolved individuals with a clinical diagnosis of CS. In total, we identified eight individuals with MORC2-related disorder, four of whom had clinical features strongly suggestive of CS. CONCLUSIONS Our findings indicate that some forms of MORC2-related disorder have phenotypic similarities to CS, including features of accelerated aging. Unlike classic DNA repair disorders, MORC2-related disorder does not appear to be associated with a defect in transcription-coupled nucleotide excision repair and follows a dominant pattern of inheritance with variants typically arising de novo. Such de novo pathogenic variants present particular challenges with regard to both initial gene discovery and diagnostic evaluations. MORC2 should be included in diagnostic genetic test panels targeting the evaluation of microcephaly and/or suspected DNA repair disorders. Future studies of MORC2 and its protein product, coupled with further phenotypic characterization, will help to optimize the diagnosis, understanding, and therapy of the associated disorders.
- Published
- 2023
23. Mellin Transforms
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Graf, Urs and Graf, Urs
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- 2010
- Full Text
- View/download PDF
24. Hankel Transforms
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Graf, Urs and Graf, Urs
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- 2010
- Full Text
- View/download PDF
25. Fourier Transforms
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Graf, Urs and Graf, Urs
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- 2010
- Full Text
- View/download PDF
26. Laplace Transforms
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Graf, Urs and Graf, Urs
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- 2010
- Full Text
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27. Analytic Properties
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Graf, Urs and Graf, Urs
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- 2010
- Full Text
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28. Introduction to Hyperfunctions
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Graf, Urs and Graf, Urs
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- 2010
- Full Text
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29. First detection of the atomic O18 isotope in the mesosphere and lower thermosphere of Earth
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Wiesemeyer, Helmut, primary, Güsten, Rolf, additional, Aladro, Rebeca, additional, Klein, Bernd, additional, Hübers, Heinz-Wilhelm, additional, Richter, Heiko, additional, Graf, Urs U., additional, Justen, Matthias, additional, Okada, Yoko, additional, and Stutzki, Jürgen, additional
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- 2023
- Full Text
- View/download PDF
30. The Spectrum of MORC2-Related Disorders: A Potential Link to Cockayne Syndrome
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Stafki, Seth A., primary, Turner, Johnnie, additional, Littel, Hannah R., additional, Bruels, Christine C., additional, Truong, Don, additional, Knirsch, Ursula, additional, Stettner, Georg M., additional, Graf, Urs, additional, Berger, Wolfgang, additional, Kinali, Maria, additional, Jungbluth, Heinz, additional, Pacak, Christina A., additional, Hughes, Jayne, additional, Mirchi, Amytice, additional, Derksen, Alexa, additional, Vincent-Delorme, Catherine, additional, Theil, Arjan F., additional, Bernard, Geneviève, additional, Ellis, David, additional, Fassihi, Hiva, additional, Lehmann, Alan, additional, Laugel, Vincent, additional, Mohammed, Shehla, additional, and Kang, Peter B., additional
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- 2023
- Full Text
- View/download PDF
31. z-Transformation with the Package
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Graf, Urs and Graf, Urs
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- 2004
- Full Text
- View/download PDF
32. Examples from Electricity
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Graf, Urs and Graf, Urs
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- 2004
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33. Examples from Control Engineering
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Graf, Urs and Graf, Urs
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- 2004
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34. Laplace Transformation: Further Topics
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Graf, Urs and Graf, Urs
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- 2004
- Full Text
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35. z-Transformation: Further Topics
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Graf, Urs and Graf, Urs
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- 2004
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36. Applications To Automatic Control
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Graf, Urs and Graf, Urs
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- 2004
- Full Text
- View/download PDF
37. Laplace Transforms with the Package
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Graf, Urs and Graf, Urs
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- 2004
- Full Text
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38. Further Techniques
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Graf, Urs and Graf, Urs
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- 2004
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39. Laplace Transformation
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Graf, Urs and Graf, Urs
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- 2004
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40. Numerical Inversion of Laplace Transforms
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Graf, Urs and Graf, Urs
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- 2004
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41. z-Transformation
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Graf, Urs and Graf, Urs
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- 2004
- Full Text
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42. Heat Conduction and Vibration Problems
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Graf, Urs and Graf, Urs
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- 2004
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43. A Compact Beam Measurement Setup
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Graf, Urs U.
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- 2016
- Full Text
- View/download PDF
44. CCAT-prime/FYST: a status report on the ultra-widefield submillimeter observatory on Cerro Chajnantor
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Stacey, Gordon J., primary, Battaglia, Nicholas, additional, Chapman, Scott C., additional, Choi, Steve K., additional, Fissel, Laura M., additional, Graf, Urs, additional, Herter, Terry, additional, Johnstone, Douglas, additional, Meerburg, P. Daniel, additional, Niemack, Michael D., additional, Nikola, Thomas, additional, Parshley, Stephen C., additional, Riechers, Domink A., additional, Simon, Robert, additional, and Vavagiakis, Eve M., additional
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- 2022
- Full Text
- View/download PDF
45. Homozygosity for a Novel DOCK7 Variant Due to Segmental Uniparental Isodisomy of Chromosome 1 Associated with Early Infantile Epileptic Encephalopathy (EIEE) and Cortical Visual Impairment
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Kivrak Pfiffner, Fatma, primary, Koller, Samuel, additional, Ménétrey, Anika, additional, Graf, Urs, additional, Bähr, Luzy, additional, Maspoli, Alessandro, additional, Hackenberg, Annette, additional, Kottke, Raimund, additional, Gerth-Kahlert, Christina, additional, and Berger, Wolfgang, additional
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- 2022
- Full Text
- View/download PDF
46. The Next Wave: Mobile & Wireless Financial Services
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Graf, Urs August, Ehrenberg, Dieter, editor, Seibt, Dietrich, editor, Stucky, Wolffried, editor, Britzelmaier, Bernd, editor, Geberl, Stephan, editor, and Weinmann, Siegfried, editor
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- 2001
- Full Text
- View/download PDF
47. Homozygosity for a Novel DOCK7 Variant Due to Segmental Uniparental Isodisomy of Chromosome 1 Associated with Early Infantile Epileptic Encephalopathy (EIEE) and Cortical Visual Impairment
- Author
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Kivrak Pfiffner, Fatma, Koller, Samuel; https://orcid.org/0000-0003-0965-0539, Ménétrey, Anika, Graf, Urs, Bähr, Luzy, Maspoli, Alessandro, Hackenberg, Annette; https://orcid.org/0000-0003-3161-8703, Kottke, Raimund; https://orcid.org/0000-0003-0166-2770, Gerth-Kahlert, Christina; https://orcid.org/0000-0001-6298-615X, Berger, Wolfgang; https://orcid.org/0000-0002-0370-3815, Kivrak Pfiffner, Fatma, Koller, Samuel; https://orcid.org/0000-0003-0965-0539, Ménétrey, Anika, Graf, Urs, Bähr, Luzy, Maspoli, Alessandro, Hackenberg, Annette; https://orcid.org/0000-0003-3161-8703, Kottke, Raimund; https://orcid.org/0000-0003-0166-2770, Gerth-Kahlert, Christina; https://orcid.org/0000-0001-6298-615X, and Berger, Wolfgang; https://orcid.org/0000-0002-0370-3815
- Abstract
Early infantile epileptic encephalopathy (EIEE) is a severe neurologic and neurodevelopmental disease that manifests in the first year of life. It shows a high degree of genetic heterogeneity, but the genetic origin is only identified in half of the cases. We report the case of a female child initially diagnosed with Leber congenital amaurosis (LCA), an early-onset retinal dystrophy due to photoreceptor cell degeneration in the retina. The first examination at 9 months of age revealed no reaction to light or objects and showed wandering eye movements. Ophthalmological examination did not show any ocular abnormalities. The patient displayed mildly dysmorphic features and a global developmental delay. Brain MRI demonstrated pontine hypo-/dysplasia. The patient developed myoclonic epileptic seizures and epileptic spasms with focal and generalized epileptiform discharges on electroencephalogram (EEG) at the age of 16 months. Genetic screening for a potentially pathogenic DNA sequence variant by whole-exome sequencing (WES) revealed a novel, conserved, homozygous frameshift variant (c.5391delA, p.(Ala1798LeufsTer59)) in exon 42 of the DOCK7 gene (NM_001271999.1). Further analysis by SNP array (Karyomapping) showed loss of heterozygosity (LOH) in four segments of chromosome 1. WES data of the parents and the index patient (trio analysis) demonstrated that chromosome 1 was exclusively inherited from the mother. Four LOH segments of chromosome 1 alternately showed isodisomy (UPiD) and heterodisomy (UPhD). In WES data, the father was a noncarrier, and the mother was heterozygous for this DOCK7 variant. The DOCK7 gene is located in 1p31.3, a region situated in one of the four isodisomic segments of chromosome 1, explaining the homozygosity seen in the affected child. Finally, Sanger sequencing confirmed maternal UPiD for the DOCK7 variant. Homozygous or compound heterozygous pathogenic variants in the DOCK7 (dedicator of cytokinesis 7) gene are associated with autosomal reces
- Published
- 2022
48. Benefits and outcomes of a new multidisciplinary approach for the management and financing of sudden unexplained death cases in a forensic setting in Switzerland
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Neubauer, Jacqueline; https://orcid.org/0000-0002-9472-7803, Kissel, Christine K; https://orcid.org/0000-0001-5814-9121, Bolliger, Stephan A, Barbon, Daniela, Thali, Michael J, Kloiber, Daniel, Bode, Peter Karl; https://orcid.org/0000-0002-9633-4042, Kovacs, Boldizsar; https://orcid.org/0000-0002-7972-5199, Graf, Urs, Maspoli, Alessandro, Berger, Wolfgang; https://orcid.org/0000-0002-0370-3815, Saguner, Ardan M; https://orcid.org/0000-0003-1896-0803, Haas, Cordula; https://orcid.org/0000-0001-8122-1427, Neubauer, Jacqueline; https://orcid.org/0000-0002-9472-7803, Kissel, Christine K; https://orcid.org/0000-0001-5814-9121, Bolliger, Stephan A, Barbon, Daniela, Thali, Michael J, Kloiber, Daniel, Bode, Peter Karl; https://orcid.org/0000-0002-9633-4042, Kovacs, Boldizsar; https://orcid.org/0000-0002-7972-5199, Graf, Urs, Maspoli, Alessandro, Berger, Wolfgang; https://orcid.org/0000-0002-0370-3815, Saguner, Ardan M; https://orcid.org/0000-0003-1896-0803, and Haas, Cordula; https://orcid.org/0000-0001-8122-1427
- Abstract
Sudden cardiac death (SCD) is an important public health issue. In young persons aged between 1 and 40 years, most SCDs are caused by potentially inherited cardiac diseases, often not detectable during conventional medico-legal investigations and therefore termed as sudden unexplained deaths (SUD). In this study, we describe the implementation, feasibility and importance of a standardized procedure to investigate SUD cases within the forensic framework at the Zurich Institute of Forensic Medicine in Switzerland. This new approach involves a multidisciplinary collaboration including forensic autopsy, second pathology expert opinion, post-mortem molecular genetic testing, cardiac counselling of relatives, and a tentative financing. This procedure is in line with the published Swiss and European recommendations on the management of SCDs. During a two-year pilot project, 39 sudden and unexpected death cases were collected, whereof 10 deceased remained without any identifiable cause of death after medico-legal investigation and second expert evaluation. Molecular autopsy, including 393 genes involved in cardio-vascular and metabolic diseases, identified eight pathogenic or likely pathogenic genetic variants in five out of the 10 deceased (50%). Cardio-genetic follow-up investigations in the families of the 10 deceased revealed phenotype-positive relatives in four families and required specific therapies, including an implantable cardioverter defibrillator (ICD) for primary prevention. Multidisciplinary collaboration is crucial for an optimal management of sudden unexplained death cases, to identify additional relatives at risk, and to prevent other tragic deaths within a family.
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- 2022
49. Terahertz Heterodyne Array Receivers for Astronomy
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Graf, Urs U., Honingh, Cornelia E., Jacobs, Karl, and Stutzki, Jürgen
- Published
- 2015
- Full Text
- View/download PDF
50. Mercenary (Landsknecht)
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Graf, Urs and Museum of Fine Arts, Boston
- Subjects
- European, Northern European, German
- Published
- 1485
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