10 results on '"Graewert, Melissa Ann"'
Search Results
2. Structural Basis for Antigen Recognition by Transglutaminase 2-specific Autoantibodies in Celiac Disease
- Author
-
Chen, Xi, Hnida, Kathrin, Graewert, Melissa Ann, Andersen, Jan Terje, Iversen, Rasmus, Tuukkanen, Anne, Svergun, Dmitri, and Sollid, Ludvig M.
- Published
- 2015
- Full Text
- View/download PDF
3. Structural and functional analysis of a plant nucleolar RNA chaperone-like protein.
- Author
-
Fernandes, Rita, Ostendorp, Anna, Ostendorp, Steffen, Mehrmann, Judith, Falke, Sven, Graewert, Melissa Ann, Weingartner, Magdalena, Kehr, Julia, and Hoth, Stefan
- Subjects
PLANT RNA ,ORGANELLE formation ,FUNCTIONAL analysis ,CELL nuclei ,NUCLEOLUS ,RIBOSOMES ,NUCLEOPHOSMIN - Abstract
Ribosome biogenesis is a key process in all eukaryotic cells that requires hundreds of ribosome biogenesis factors (RBFs), which are essential to build the mature ribosomes consisting of proteins and rRNAs. The processing of the required rRNAs has been studied extensively in yeast and mammals, but in plants much is still unknown. In this study, we focused on a RBF from A. thaliana that we named NUCLEOLAR RNA CHAPERONE-LIKE 1 (NURC1). NURC1 was localized in the nucleolus of plant cell nuclei, and other plant RBF candidates shared the same localization. SEC-SAXS experiments revealed that NURC1 has an elongated and flexible structure. In addition, SEC-MALLS experiments confirmed that NURC1 was present in its monomeric form with a molecular weight of around 28 kDa. RNA binding was assessed by performing microscale thermophoresis with the Arabidopsis internal transcribed spacer 2 (ITS2) of the polycistronic pre-rRNA precursor, which contains the 5.8S, 18S, and 25S rRNA. NURC1 showed binding activity to the ITS2 with a dissociation constant of 228 nM and exhibited RNA chaperone-like activity. Our data suggested that NURC1 may have a function in pre-rRNA processing and thus ribosome biogenesis. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
4. Molecular basis of F-actin regulation and sarcomere assembly via myotilin
- Author
-
Kostan, Julius, primary, Pavšič, Miha, additional, Puž, Vid, additional, Schwarz, Thomas C., additional, Drepper, Friedel, additional, Molt, Sibylle, additional, Graewert, Melissa Ann, additional, Schreiner, Claudia, additional, Sajko, Sara, additional, van der Ven, Peter F. M., additional, Onipe, Adekunle, additional, Svergun, Dmitri I., additional, Warscheid, Bettina, additional, Konrat, Robert, additional, Fürst, Dieter O., additional, Lenarčič, Brigita, additional, and Djinović-Carugo, Kristina, additional
- Published
- 2021
- Full Text
- View/download PDF
5. Molecular basis of F-actin regulation and sarcomere assembly via myotilin
- Author
-
Kostan, Julius, primary, Pavšič, Miha, additional, Puž, Vid, additional, Schwarz, Thomas C., additional, Drepper, Friedel, additional, Molt, Sibylle, additional, Graewert, Melissa Ann, additional, Schreiner, Claudia, additional, Sajko, Sara, additional, van der Ven, Peter F.M., additional, Svergun, Dmitri I., additional, Warscheid, Bettina, additional, Konrat, Robert, additional, Fürst, Dieter O., additional, Lenarčič, Brigita, additional, and Djinović-Carugo, Kristina, additional
- Published
- 2020
- Full Text
- View/download PDF
6. Chapter 372 - PhTET2 Aminopeptidase
- Author
-
Gräwert, Melissa Ann and Groll, Michael
- Published
- 2013
- Full Text
- View/download PDF
7. ChemInform Abstract: Exploiting Nature′s Rich Source of Proteasome Inhibitors as Starting Points in Drug Development
- Author
-
Graewert, Melissa Ann, primary and Groll, Michael, additional
- Published
- 2012
- Full Text
- View/download PDF
8. Contributors
- Author
-
Abbott, Catherine Anne, Abraham, Carmela R., Adachi, Hideki, Adachi, Osao, Adam, Zach, Adams, Michael W.W., Adang, Michael J., Adham, Ibrahim, M., Aducci, Patrizia, Agard, David A., Agranovsky, Alexey A., Akamatsu, Tetsuya, Akiyama, Yoshinori, Albrechtsen, Reidar, Alejo, Ali, Amberg, Sean M., Amerik, Alexander Y., Amparyup, Piti, Andrade, Felipe, Andrés, Germán, Andrews, Daniel M., Andrews, Robert K., Antalis, Toni M., Anthony, Colin S., Aoki, Naoya, Apte, Suneel S., Arima, Kazunari, Arlaud, Gérard, Arni, Raghuvir Krishnaswamy, Arnoux, Pascal, Aronson, Nathan N., Jr., Arthur, Michel, Asano, Yasuhisa, Ascenzi, Paolo, Assakura, Marina T., Auld, David S., Ávila, Veridiana de Melo Rodrigues, Avilés, Francesc X., Awad, William M., Jr., Bachhawat, Anand K., Bai, Shan, Baird, Teaster T., Jr., Bajaj, S. Paul, Baker, Susan C., Banbula, Agnieszka, Barrett, Alan J., Barrowman, Jemima, Bartlett, John D., Bartsch, Jörg W., Baschuk, Nikola, Baskova, Isolda P., Batra, Jyotsna, Bauer, Karl, Baumann, Ulrich, Baumeister, Wolfgang, Bauvois, Cédric, Bayés, Alex, Beauvais, Anne, Becker-Pauly, Christoph, Begley, Tadhg P., Békés, Miklós, Belas, Robert, Beleford, Daniah, Beppu, Teruhiko, Bergmann, Ernst M., Bernard, Bruno A., Bernard, Dominique, Berndt, Michael C., Berruti, Giovanna, Berry, Colin, Bertenshaw, Greg P., Betzel, Christian, Bhaskarla, Chetana, Bhosale, Manoj, Bierbaum, Gabriele, Bjarnason Jón, B., Blaber, Michael, Blackman, Michael J., Blinkovsky, Alexander, Boeke, Jef D., Bogyo, Matthew, Bohn, Stefan, Boileau, Guy, Boland, Mike, Bolken, Tové C., Bond, Judith S., Bondeson, Jan, Bordallo, Javier, Borelli, Claudia, Botelho, Tiago O., Bott, Richard R., Bourne, David G., Bovenschen, Niels, Bradshaw, Ralph A., Breddam, Klaus, Brew, Keith, Brindley, Paul J., Brinkman, Diane L., Britton, Collette, Broadbent, Jeff R., Broadhurst, Anne, Brómme, Dieter, Broom, Murray, Brown, Jeremy S., Brown, Mark A., Bruchhaus, Iris, Burleigh, Barbara A., Burns, Kristin E., Burrows, James F., Butler, Michael J., Buttle, David J., Byrd, Chelsea M., Byun, Tony, Cadel, Sandrine, Caffrey, Conor R., Cal, Santiago, Caldentey, Javier, Candela, Thomas, Capasso, Clemente, Capriogilio, Daniel R., Carginale, Vincenzo, Carmona, Adriana Karaoglanovic, Carruthers, Vern B., Castellino, Francis J., Catanese, Joseph J., Caterson, Bruce, Caughey, George H., Cawley, Naimh X., Cawston, Tim E., Cazzulo, Juan José, Chai, Jijie, Chai, Karl X., Chaim, Olga Meiri, Chang, L.S., Chao, Julie, Chapot-Chartier, Marie-Pierre, Charli, Jean-Louis, Charlier, Paulette, Chave, Karen J., Chen, Jian-Min, Chen, Jinq-May, Chen, Li-Mei, Chen, Ya-Wen, Chen, Yu-Yen, Chevrier, Bernard, Chich, Jean-François, Chien, Jeremy, Chimalapati, Suneeta, Cho, Ki Joon, Choi, Kwan Yong, Chuang, Woei-Jer, Chung, Chin Ha, Chung, Ivy Yeuk Wah, Clamagirand, Christine, Clark, Ian M., Clarke, Adrian K., Clarke, Nicola E., Clarke, Steven Gerard, Clauziat, Philippe, Clements, Judith A., Coffinier, Catherine, Cohen, Paul, Colige, Alain, Collignon, Anne, Colloms, Sean D., Conzelmann, Andreas, Coombs, Graham H., Cooney, Jakki C., Cooper, Jonathan B., Cooper, Max D., Copeland, Nikki A., Cottrell, Graeme S., Coyle, Joseph T., Craik, Charles S., Creemers, John W.M., Cretu, Daniela, Croce, Jenifer, Cross, Keith J., Cueva, Rosario, Cui, Sheng, Cunha, Luis, Cutting, Simon, d’Enfert, Christophe, D’Orchymont, Hugues, Dahlbäck, Björn, Dai, Shujia, Dalbey, Ross E., Dalton, John P., Dando, Pam M., Daniel, R.M., Danilov, Sergei M., Davies, Donna E., De Araujo, Heloisa S., De los Santos, Teresa, de Luca, Viviana, De Meester, Ingrid, de Oliveira, Ana Karina, de Oliveira, Eduardo Brandt, De Oliveira, Pedro Lagerblad, de Vos, Sarah, Declercq, Jeroen, Declercq, Wim, Deghmane, Ala-Eddine, Dekker, Niek, Del Prete, Sonia, Del Rosal, Marina, Delmas, Bernard, DeLotto, Robert, Demidyuk, Ilya V., Denison, Mark R., Deussing, Jan M., Devi, Lakshmi A., Diamandis, Eleftherios P., Diaz, Isabel, Díaz-Perales, Araceli, Dijkstra, Bauke W., Ding, Yan, Dixon, Jack E., Dodt, Johannes, Dokland, Terje, Dolenc, Iztok, Dong, Ningzheng, Dong, Tran Cat, Dong, Ying, Dongre, Mitesh, Donovan, Mark, Dore, Timothy M., Dorstyn, Loretta, Dou, Hong, Dou, Zhicheng, Dougall, Annette M., Drag, Marcin, Dudley, Edward G., Dunn, Ben M., Dupuy, Bruno, Duque-Magalhāes, Maria Conceicāo, Durá, M. Asunción, Eeckhout, Yves, Eijsink, Vincent, Eisen, Arthur Z., Eissa, Azza, Eklund, Sandra, Eletr, Ziad M., Ellis, Vincent, Engel, Wolfgang, Erdös, Ervin G., Escalante, Teresa, Estell, David A., Etscheid, Michael, Evans, Herbert J., Everett, Roger D., Faesen, Alex C., Fahrenholz, Falk, Fanjul-Fernández, Miriam, Farady, Christopher J., Feller, Georges, Feng, Hong, Fenster, Kurt M., Férec, Claude, Ferrari, Silvia, Fingleton, Barbara, Fisher, Jed F., Fives-Taylor, Paula M., Fong, Loren G., Forneris, F., Forster, Brian M., Forster, Friedrich, Foster, Simon J., Foulon, Thierry, Foundling, Stephen I., Fox, Jay William, Franzetti, Bruno, Frasch, Alejandra P., Freeze, Hudson H., Frère, Jean-Marie, Frey, Teryl K., Fricke, Beate, Fricker, Lloyd D., Fridman, Rafael, Froelich, Christopher J., Fröhlich, Camilla, Fu, Hsueh-Liang, Fuhrmann, Cynthia N., Fujimura, Satoshi, Fujiwara, Hiroshi, Fukushima, Jun, Fukuyama, Keiichi, Fuller, Robert S., Fusek, Martin, Gaboriaud, Christine, Gache, Christian, Gakh, Oleksandr, Gal, Peter, Gao, Junjun, García-Sastre, Adolfo, Gardiner, Donald L., Gatehouse, John A., Gaucher, G.M., Gauthier, Francis, Ghuysen, Jean-Marie, Gibson, Wade, Gillies, Jennifer, Glaser, Elzbieta, Glaser, Fabian, Glickman, Michael H., Goettig, Peter, Goffin, Colette, Gohda, Eiichi, Goldberg, Alfred L., Goldberg, Daniel E., Goldberg, Gregory I., Goldfarb, Nathan E., Gomis-Rüth, F. Xavier, Gopal, B., Gorbalenya, Alexander E., Gordon, Stuart G., Gorrell, Mark D., Götz, Friedrich, Goulas, Theodoros, Gouzy-Darmon, Cécile, Govind, K., Gráf, Lászlo, Granados, Robert R., Gräwert, Melissa Ann, Gray, Douglas A., Graycar, Thomas P., Green, Jonathan A., Gremski, Luiza Helena, Groll, Michael, Gromova, Tania Yu, Gros, P., Grubman, Marvin J., Grunden, Amy M., Gudmundsdóttir, Ágústa, Guinand, Micheline, Gully, Djamel, Gustchina, Alla, Gutiérrez, José María, Ha, Byung Hak, Haeggström, Jesper Z., Hageman, James H., Haiko, Johanna, Hailfinger, Stephan, Haitchi, Hans Michael, Han, Ji Seon, Hanquez, Chantal, Harada, Minoru, Hara-Nishimura, Ikuko, Harboe, Marianne, Härd, Torleif, Harris, David A., Hassiepen, Ulrich, Hata, Shoji, Hattori, Akira, He, Rong-Qiao, Heck, Albert J.R., Hendricks, Dirk F., Henrich, Bernhard, Henriet, Patrick, Hernández-Arana, Andrés, Herrera-Camacho, Irma, Heussipp, Gerhard, Hibino, Toshihiko, Hicks, P.M., Hillman, Bradley I., Hiraoka, B. Yukihiro, Hiratake, Jun, Hizukuri, Yohei, Ho, Heng-Chien, Hoa, Ngo Thi, Hochstrasser, Mark, Hodge, Kathryn M., Hofmann, Theo, Hohn, Thomas, Hoidal, John R., Höltje, Joachim-Volker, Homma, Koichi J., Honek, John F., Hook, Vivian Y.H., Hooper, John D., Hooper, Nigel M., Hosoi, Kazuo, Howe, Christopher J., Hruby, Dennis E., Hseih, James J.-D., Hsu, Chun-Chieh, Huang, Tony T., Huang, Tur-Fu, Huet, Yoann, Hughes, Clare, Hugonnet, Jean-Emmanuel, Huston, Adrienne L., Ibrahim-Granet, Oumaïma, Ichishima, Eiji, Ikehara, Yukio, Inagami, Tadashi, Ingram, Jessica, Isaac, R.E., Isaya, Grazia, Isaza, Clara E., Ishii, Shin-ichi, Isnard, Amandine, Ito, Kiyoshi, Ito, Koreaki, Itoh, Yoshifumi, Iturrioz, Xavier, Iwanaga, Sadaaki, Jack, Ralph W., Jackson, Mel C., James, Michael N.G., Janata, Jiří, Janoir, Claire, Janska, Hanna, Jarrell, Ken F., Jaskolski, Mariusz, Jaswal, Sheila S., Jean, Ying Y., Jenne, Dieter E., Jeon, Young Joo, Jiang, Ping, Johnson, John E., Johnson, Michael D., Johnston, James A., Jones, Amanda, Jones, Elizabeth W., Joudiou, Carine, Juliano, Luiz, Jung, Hea-Jin, Jupp, Ray, Kagawa, Todd F., Kalbacher, Hubert, Kamata, Yayoi, Kaminogawa, Shuichi, Kamio, Yoshiyuki, Kaneda, Makoto, Kang, Sung Gyun, Kang, Sung Hwan, Kania, Mary, Kantyka, Tomasz, Kanzawa, Nobuyuki, Karim, Abdulkarim Y., Kasumi, Takafumi, Kataoka, Hiroaki, Kaur, Hardeep, Kawabata, Shun-Ichiro, Kawaguchi, Mari, Kay, John, Kaynar, Murat, Keiler, Kenneth C., Kelly, R.M., Kenton, Nathaniel T., Kerr, Michael A., Kersse, Kristof, Kervinen, Jukka, Kessler, Benedikt M., Kessler, Efrat, Khoronen, Timo K., Kidd, Simon, Kikkert, Marjolein, Kilian, Mogens, Kim, Do-Hyung, Kim, Doyoun, Kim, Eunice EunKyeong, Kim, In Seop, Kim, Jung-Gun, Kim, Kyeong Kyu, Kim, Kyung Hyun, Kimber, Matthew S., Kimura, Yukio, Kirschke, Heidrun, Kiso, Yoshiaki, Kleanthous, Colin, Klein, Jürgen R., Klemba, Michael, Kmiec, Beata, Kobayashi, Hideyuki, Kodama, Hiroyuki, Koelsch, Gerald, Kok, Jan, Kolattukody, P.E., Kolb, Fabrice A., Kolmar, Harald, Komori, Yumiko, Konvalinka, Jan, Korkmaz, Brice, Kostrov, Sergey V., Kräusslich, Hans-Georg, Krczal, Gabi, Kress, Lawrence F., Kristjánsson, Magnüs Már, Kučera, Tomáš, Kukday, Sayali S., Kumagai, Hidehiko, Kumar, Sharad, Kumarasiri, Malika, Kumazaki, Takashi, Kümmerer, Beate M., Kuno, Kouji, Kurkinen, Markku, Kutejová, Eva, Kveiborg, Marie, Kwarciak, Agnieszka, Laakkonen, Liisa, Labrou, Nikolaos E., Laing, Gavin D., Lamppa, Gayle, Langer, Thomas, Laursen, Richard A., Lawrenson, Richard A., Layne, Matthew D., Le Bonniec, Bernard F., Leal, María C., Lechan, Ronald M., Lee, David H., Lee, Irene, Lee, Jae, Lee, Kye Joon, Lee, Soohee, Lei, Xiaobo, Leis, Jonathan, LeMosy, Ellen K., Lepage, Thierry, Leppla, Stephen H., Lesner, Adam, Lessard, Ivan A.D., Lhomond, Guy, Li, Huilin, Li, Shu-Ming, Li, Weiguo, Liao, Ta-Hsiu, Liddington, Robert C., Lieber, Toby, Lijnen, H.R., Lima, Christopher D., Lin, Chen-Yong, Lin, Gang, Lin, Ming T., Lin, Xinli, Lin, Yee-Shin, Lindsay, L.L., Lipscomb, William N., Little, John W., Liu, Ching-Chuan, Liu, Chuan-ju, Lively, Mark O., Livnat-Levanon, Nurit, Ljungdahl, Per O., Llorens-Cortes, Catherine, Lobel, Peter, Loh, Y. Peng, Lohi, Jouko, Lomonossoff, G.P., Looze, Yvan, López-Otin, Carlos, Lopez-Quezada, Landys, Loukas, Alex, Lu, Long-Sheng, Lundwall, Áke, Luo, Liu-Ying, Lupas, Andrei, Luthe, Dawn S., Lynch, Nicholas J., Lyons, Peter J., MacKay, Vivian L., Macleod, Jesica M. Levingston, Magdolen, Viktor, Mainardi, Jean-Luc, Mäkinen, Kauko K., Mallari, Jeremy P., Manandhar, Surya P., Mandelbaum, Fajga R., Manicone, Anne M., Mansfeld, Johanna, Marcotrigiano, Joseph, Mares, Michael, Marfany, Gemma, Markland, Francis S., Jr., Marokházi, Judith, Marquis, Hélène, Marr, Robert A., Martegani, Enzo, Martin, Erik W., Martinez, Manuel, Martins, L. Miguel, Maruyama, Masato, Maruyama, Masugi, Maruyama, Sususmu, Masaki, Takeharu, Massoumi, Ramin, Mathew, Rency T., Matrisian, Lynn M., Matsuda, Yoshihiro, Matsushita, Osamu, Matuschek, Marco, Matušková, Anna, Matúz, Krisztina, Mauch, Cornelia, Maurizi, Michael R., Mayr, Lorenz M., McCafferty, Dewey G., McDonald, J. Ken, McKerrow, James H., McMillan, David, Mecham, Robert P., Mehta, Darshini P., Meisinger, Chris, Mellors, Alan, Melton, Roger G., Melvin, Jeffrey A., Ménard, Robert, Menéndez-Arias, Luis, Menezes, Milene C., Mesecar, Andrew, Mesnage, Stéphane, Meyer, Diane H., Meyers, Gregor, Michaelis, Susan, Michalska, Karolina, Mielicki, Wojciech P., Mierau, Igor, Mikoulinskaia, Galina V., Miller, Charles G., Miller, Lydia K., Mills, John, Mills, Kenneth V., Min, Jinrong, Mistou, Michel-Yves, Misumi, Yoshio, Miyoshi, Shin-ichi, Mizutani, Shigehiko, Mobashery, Shahriar, Mochizuki, Satsuki, Mock, William L., Möhrlen, Frank, Moiré, Nathalie, Monahan, Paul E., Moncada-Pazos, Angela, Monnet, Véronique, Monod, Michel, Montecucco, Cesare, Morelli, Laura, Mori, Sumiko, Morita, Takashi, Morrissey, James H., Morse, Richard J., Mort, John S., Mortensen, Uffe H., Morty, Rory E., Moss, Joel, Motoshima, Hidemasa, Mottram, Jeremy C., Moura-da-Silva, Ana M., Mudgett, Mary Beth, Mundt, Egbert, Murakami, Kazuo, Murakami, Mario Tyago, MurakamiMurofoshi, Kimiko, Murao, Sawao, Murphy, Gillian, Murthy, M.R.N., Muta, Tatsushi, Myburgh, Elmarie, Mzhavia, Nino, Nabi, A.H.M. Nurun, Nagase, Hideaki, Nagle, Michael W., Nägler, Dorit K., Naik, Rajesh R., Nair, Divya B., Nakai, Toshiki, Nakajima, Yoshitaka, Nakamura, Yukio, Nakatogawa, Hitoshi, Nakayama, Toru, Nalivaeva, Natalia N., Nandi, Dipankar, Nascimento-Silva, Maria Clara Leal, Nasmyth, Kim, Nathan, Carl F., Navarro-García, Fernando, Naves, Dayane Lorena, Nedialkova, Danny D., Neuman, Keir C., Nguyen, Jeffrey-Tri, Nguyen, Ky-Anh, Niemirowicz, Gabriela T., Nikai, Toshiaki, Nishi, Eiichiro, Nishii, Wataru, Nishiyama, Makoto, Nishiyama, Yasuhiro, Noda, Masatoshi, Nomura, Seiji, Norioka, Shigemi, Nsangou, Desire M.M., O’Brien, Amornrat, O’Connor, Michael B., Oda, Kohei, Odinokova, Irina V., Oetjen, Joyce, Ogura, Teru, Ohman, Dennis E, Ohsumi, Yoshinori, Ojha, Mukti, Okabe, Akinobu, Okada, Yasunori, Okamoto, Keinosuke, Okuda, Kenji, Okumura, Nobuaki, Okuno, Takashi, Oleson, Kjeld, Oliveira de Giuseppe, Priscila, Olivier, Martin, Ono, Yasuko, Oroszlan, Stephen, Ota, Nobuyuki, Ovadia, Michael, O-Wang, Jiyang, Oxvig, Claus, Packer, Jeremy C.L., Padilla-López, Sergio, Paetzel, Mark, Page, Michael J., Page-McCaw, Andrea, Paine, Mark J.I., Park, Byoung Chul, Park, Eunyong, Park, John E., Park, Pyong Woo, Park, Sung Goo, Parkin, Kirk L., Parks, William C, Paschoalin, Thaysa, Pastore, Annalisa, Patananan, Alexander Nikolich, Paul, Sudhir, Paulson, Henry L., Pawel-Rammingen, Ulrich von, Pearce, David A., Pearson, Mark S., Pei, Duanqing, Pejler, Gunnar, Pemberton, Alan D., Peng, Jianhao, Pernier, Julien, Peters, Jan-Michael, Pfirrmann, Thorsten, Pham, Viet-Laï, Pichová, Iva, Pickering, Darren, Piesse, Christophe, Pignol, David, Pike, Robert N., Pinck, Lothaire, Pirkle, Hubert, Pitot, Henry C., Plaut, Andrew G., Ploegh, Hidde, Polgár, László, Porter, Corrine, Postina, Rolf, Potempa, Jan, Poulsen, Knud, Power, Scott D., Pratt, Rex. F., Prehna, Gerd, Prévost, Gilles, Pshezhetsky, Alexey V., Qasim, Mohammad A., Qian, Feng, Qiu, Jiazhou, Radisky, Evette S., Rader, Stephen D., Raman, Kavita, Ramsay, Andrew J., Rancourt, Derrick E., Ranjit, Najju, Rao, Narayanam V., Ratia, Kiira, Rawlings, Neil D., Rawson, Robert B., Reddy, Vijay, Redman, Colvin M., Regonesi, Maria Elena, Reichert, Andreas S., Reichl, Antonia P., Remaut, Han, Remington, S. James, Renatus, Martin, Reverter, David, Reynolds, Eric C., Rholam, Mohamed, Rice, Charles M., Ridky, Todd W., Riezman, Howard, Rijken, D.C., Rio, Marie-Christine, Ritchie, Alison, Robert-Baudouy, Janine, Robinson, Mark W., Robinson, Michael, Rodriguez-Romero, Adela, Rodriques, Renata Santos, Rogers, John C., Rojas, Camilo, Romesberg, Floyd E., Roper, David J., Rosas-Murrieta, Nora, Rose, A.M., Rosenthal, Philip J., Rosing, J., Rossetto, Ornella, Rossi, Véronique, Roth, Richard A., Rottensteiner, Hanspeter, Rowan, Andrew D., Rozanov, Mikhail, Rucavado, Alexandra, Ruecker, Andrea, Rul, Françoise, Rümenapf, Till, Russo, Ilaria, Ryan, Martin D., Sacco, Elena, Sadler, J. Evan, Saenger, W., Sahl, Hans-Georg, Sajid, Mohammed, Sakaguchi, Masayoshi, Sakiyama, Fumio, Salas, Maria L., Salgado, Maria Cristina O., Salvesen, Guy S., Sánchez, Edith, Sanchez, Eladio F., Sang, Qing-Xiang Amy, Sankaran, Krishnan, Sarkar, Susanta K., Sarras, Michael P., Jr., Sasagawa, Yoshikiyo, Satohiko, Araki, Sauvage, Eric, Saveanu, Loredana, Savithri, H.S., Sawada, Hitoshi, Sawers, R. Gary, Scarisbrick, Isobel A., Schaller, Andreas, Scheer, Justin M., Scheiflinger, Friedrich, Schiene-Fischer, Cordelia, Schlomann, Uwe, Schlösser, Manfred, Schmaier, Alvin H., Schmidt, Walter K., Schneemann, Anette, Schnellmann, Rick G., Scholze, Henning, Schomburg, Lutz, Schwaeble, Wilhelm J., Scott, Christopher J., Scudiero, Rosaria, Sehara-Fujisawa, Atsuko, Seidah, Nabil G., Seiki, Motoharu, Sekiguchi, Junichi, Senff-Ribeiro, Andrea, Seong, Ihn Sik, Serpe, Mihaela, Serrano, Solange M.T., Setlow, Peter, Shahian, Tina, Shanks, M., Shao, Feng, Shapiro, Steven D., Sharma, Navneet, Shaw, Lindsey N., Shen, Aimee, Shen, Lei, Sherwood, Roger F., Shi, Yun-Bo, Shimoi, Hitoshi, Shimura, Yoichiro, Shirras, A.D., Shridhar, Viji, Shukla, Jinal K., Siigur, Ene, Siigur, Jüri, Silmon de Monerri, Natalie C., Sim, Robert B., Simmer, James P., Simmons, William H., Singh, Jaspreet, Singleton, Alison, Sirakova, Tatiana D., Sixma, Titia K., Skern, Tim, Skidgel, Randal A., Slack, Jeffrey, Sleat, David E., Slusher, Barbara S., Smith, Janet L., Smith, Matthew A., Smyth, Mark J., Snijder, Erik J., Sobhanifar, Solmaz, Söderhaäll, Kenneth, Sohar, Istvan, Sonderegger, Peter, Sorgine, Marcos Henrique Ferreira, Sorimachi, Hiroyuki, Soukhodolets, Karen E., Souza, Tatiana de Arruda Campos Brasil de, Sperka, Tamás, Sriskandan, Shiranee, St. Geme, Joseph W., III, St. Leger, Raymond J., Staib, Peter, Steele, James L., Stefansson, Bjarki, Steinkühler, Christian, Stenberg, Leisa M., Stenflo, Johan, Stennicke, Henning R., Stepanov, Valentin M., Stepnaya, Olga A., Steven, Frank, Stevens, Richard L., Stevenson, Kenneth J., St-Louis, Mathieu, Stobart, Christopher C., Stöcker, Walter, Storer, Andrew C., Sträter, Norbert, Strauss, Ellen G., Strauss, James H., Stříšovský, Kvido, Strynadka, Natalie C.J., Sturrock, Edward D., Su, Dan, Su, Xiao-Dong, Suárez-Rendueles, Paz, Sulea, Traian, Sundararajan, Venkatesh, Suno, Ryoji, Suzuki, Carolyn K., Suzuki, Fumiaki, Suzuki, Hideyuki, Suzuki, Nobuhiro, Swenson, Stephen, Szabady, Rose L., Szecsi, Pal Bela, Szilágyi, Lászlo, Taha, Muhamed-Kheir, Takahashi, Eizo, Takahashi, Kenji, Takai, Toshiro, Takeda, Atsushi, Takeda, Soichi, Tame, Jeremy J.R.H., Tamura, Tomohiro, Tan, Fulong, Tanaka, Keiji, Tanase, Carmen, Tang, Jordan, Tanizaki, Martha M., Tannich, Egbert, Tans, Guido, Tarentino, Anthony L., Tassanakajon, Anchalee, Tatsumi, Hiroki, Tautz, Norbert, Taylor, Erin Bassford, Teixeira, Pedro Filipe, Telugu, Bhanu Prakash V.L., Templin, Markus F., Terada, Shigeyuki, Tetsuya, Uchikoba, Thacker, C., Thaker, Maulik, Thiel, Heinz-Jürgen, Thielens, Nicole, Thierry, Gonzales, Thivierge, Karine, Thomas, Mark D., Thome, Margot, Thorsness, Mary K., Thorsness, Peter E., Tigue, Natalie J., Todi, Sokol V., Tomkinson, Birgitta, Tonello, Fiorella, Tong, Liang, Toogood, H.S., Tortora, Paolo, Tözsèr, József, Travassos, Luiz Rodolpho, Travis, James, Trevisan-Silva, Dilza, Trinchella, Francesca, Trivedi, Neil N., Troy, Carol M., Tschesche, Harald, Tseng, Yu-Lun, Tsujimoto, Masafumi, Tu, Anthony T., Tumelty, Kathleen E., Turk, Boris, Turk, Dusan, Turk, Vito, Turner, Anthony J., Uchikoba, Tetsuya, Ueno, Takayuki, Ugalde, Alejandro P., Uitto, Veli-Jukka, Urban, Sinisa, Valdenaire, Olivier, Valli, Adrian, Van Beeumen, Jozef, Van den Burg, Bertus, Van der Hoorn, Renier A.L., van Dijl, Jan Maarten, Van Endert, Peter, Van Raam, Bram J., Van Wart, Harold E., Vanden Berghe, Tom, Vandenabeele, Peter, Vanoni, Margo, Veiga, Silvio Sanches, Velander, William H., Velasco, Gloria, Vendrell, Josep, Venekei, I. István, Vetvicka, Vaclav, Vögtle, F.-Nora, Vollmer, Waldemar, Wada, Kei, Wagner, Fred W., Wai, Sun Nyunt, Wai, Timothy, Wainwright, Shane, Walker, Kenneth W., Walker, Stephen J., Wallach, Jean, Walling, Linda L., Walsh, Peter N., Wang, Hai-Yan, Wang, Hengbin, Wang, Jianwei, Wang, Peng, Wang, Ping, Wassenegger, Michael, Watanabe, Kunihiko, Webb, Helen, Weber, Joseph M., Weber, Niklas, Webster, Daniel R., Wei, Shuo, Welch, Rodney A., Wells, James A., Wenzel, Herbert, Wertz, Ingrid E., Wewer, Ulla W., Whyteside, Alison R., Wilk, Sherwin, Wilkin, Jean-Marc, Wilmes, Claudia, Winther, Jakob R., Wishart, David S., Wlodawer, Alexander, Woessner, J. Fred, Wolfe, Michael S., Wong, Wilson, Woodgate, Roger, Wright, Gerry, Wu, Jiunn-Jong, Wu, Qingyu, Wysocka, Magdalena, Xu, Chao, Xu, Zhenghong, Yahori, Kinnosuke, Yamada, Shoji, Yamaguchi, Nozomi, Yamaguchi, Shinji, Yamakawa, Yoshio, Yamamoto, Hiroki, Yana, Ikao, Yang, Maozhou, Yang, Na, Yao, Chenjuan, Yao, Tingting, Yasuda, Noriko, Yasuhara, Toshimasa, Yasumasu, Shigeki, Yeh, Edward T.H., Yiallouros, Irene, Yin, Jiang, Yonezawa, Hiroo, Yoo, Soon Ji, Yoshimoto, Tadashi, Young, Michael W., Young, Stephen G., Zaidi, Nousheen, Zavalova, Ludmila L., Zavodszky, Peter, Zhang, Aidong, Zhang, Xianming, Zhang, Yi-Zheng, Zheng, Dominick, Zhong, Guangming, Zhong, Rong, Zhou, Yuan, Zhou, Zhaohui Sunny, Zick, Michael, Zigrino, Paola, and Zimin, Andrei A.
- Published
- 2013
- Full Text
- View/download PDF
9. Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2
- Author
-
Custódio, Tânia F., Das, Hrishikesh, Sheward, Daniel J., Hanke, Leo, Pazicky, Samuel, Pieprzyk, Joanna, Sorgenfrei, Michèle, Schroer, Martin A., Gruzinov, Andrey Yu., Jeffries, Cy M., Graewert, Melissa Ann, Svergun, Dmitri I., Dobrev, Nikolay, Remans, Kim, Seeger, Markus A., McInerney, Gerald M., Murrell, Ben, Hällberg, B. Martin, and Löw, Christian
- Subjects
3. Good health - Abstract
Nature Communications 11(1), 5588 (1-11) (2020). doi:10.1038/s41467-020-19204-y, The coronavirus SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Therapeutic neutralizing antibodies constitute a key short-to-medium term approach to tackle COVID-19. However, traditional antibody production is hampered by long development times and costly production. Here, we report the rapid isolation and characterization of nanobodies from a synthetic library, known as sybodies (Sb), that target the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. Several binders with low nanomolar affinities and efficient neutralization activity were identified of which Sb23 displayed high affinity and neutralized pseudovirus with an IC$_{50}$ of 0.6 µg/ml. A cryo-EM structure of the spike bound to Sb23 showed that Sb23 binds competitively in the ACE2 binding site. Furthermore, the cryo-EM reconstruction revealed an unusual conformation of the spike where two RBDs are in the ‘up’ ACE2-binding conformation. The combined approach represents an alternative, fast workflow to select binders with neutralizing activity against newly emerging viruses., Published by Nature Publishing Group UK, [London]
10. Structural basis for antigen recognition by transglutaminase 2-specific autoantibodies in celiac disease.
- Author
-
Xi Chen, Hnida, Kathrin, Graewert, Melissa Ann, Andersen, Jan Terje, Iversen, Rasmus, Tuukkanen, Anne, Svergun, Dmitri, and Sollid, Ludvig M.
- Subjects
- *
TRANSGLUTAMINASES , *AUTOANTIBODIES , *CELIAC disease , *ANTIGENS , *X-ray scattering - Abstract
Antibodies to the autoantigen transglutaminase 2 (TG2) are a hallmark of celiac disease. We have studied the interaction between TG2 and an anti-TG2 antibody (679-14-E06) derived from a single gut IgA plasma cell of a celiac disease patient. The antibody recognizes one of four identified epitopes targeted by antibodies of plasma cells of the disease lesion. The binding interface was identified by small angle X-ray scattering, ab initio and rigid body modeling using the known crystal structure of TG2 and the crystal structure of the antibody Fab fragment, which was solved at 2.4 Å resolution. The result was confirmed by testing binding of the antibody to TG2 mutants by ELISA and surface plasmon resonance. TG2 residues R116 and H134 were identified to be critical for binding of 679-14-E06 as well as other epitope 1 antibodies. In contrast, antibodies directed toward the two other main epitopes (epitopes 2 and 3) were not affected by these mutations. Molecular dynamics simulations suggest interactions of 679-14-E06 with the N-terminal domain of TG2 via the CDR2 and CDR3 loops of the heavy chain and the CDR2 loop of the light chain. In addition there were contacts of the framework 3 region of the heavy chain with the catalytic domain of TG2. The results provide an explanation for the biased usage of certain heavy and light chain gene segments by epitope 1-specific antibodies in celiac disease. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.