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2. Accelerometry-based classification of circulatory states during out-of-hospital cardiac arrest

Author

Kern, Wolfgang J., Orlob, Simon, Bohn, Andreas, Toller, Wolfgang, Wnent, Jan, Gräsner, Jan-Thorsten, and Holler, Martin

Subjects
Electrical Engineering and Systems Science - Signal Processing, Computer Science - Machine Learning, J.3
Abstract

Objective: Exploit accelerometry data for an automatic, reliable, and prompt detection of spontaneous circulation during cardiac arrest, as this is both vital for patient survival and practically challenging. Methods: We developed a machine learning algorithm to automatically predict the circulatory state during cardiopulmonary resuscitation from 4-second-long snippets of accelerometry and electrocardiogram (ECG) data from pauses of chest compressions of real-world defibrillator records. The algorithm was trained based on 422 cases from the German Resuscitation Registry, for which ground truth labels were created by a manual annotation of physicians. It uses a kernelized Support Vector Machine classifier based on 49 features, which partially reflect the correlation between accelerometry and electrocardiogram data. Results: Evaluating 50 different test-training data splits, the proposed algorithm exhibits a balanced accuracy of 81.2%, a sensitivity of 80.6%, and a specificity of 81.8%, whereas using only ECG leads to a balanced accuracy of 76.5%, a sensitivity of 80.2%, and a specificity of 72.8%. Conclusion: The first method employing accelerometry for pulse/no-pulse decision yields a significant increase in performance compared to single ECG-signal usage. Significance: This shows that accelerometry provides relevant information for pulse/no-pulse decisions. In application, such an algorithm may be used to simplify retrospective annotation for quality management and, moreover, to support clinicians to assess circulatory state during cardiac arrest treatment., Comment: 12 pages, 7 figures

Published
2022
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12. International variation in survival after out-of-hospital cardiac arrest: A validation study of the Utstein template

Author

Dyson, Kylie, Brown, Siobhan P., May, Susanne, Smith, Karen, Koster, Rudolph W., Beesems, Stefanie G., Kuisma, Markku, Salo, Ari, Finn, Judith, Sterz, Fritz, Nürnberger, Alexander, Morrison, Laurie J., Olasveengen, Theresa M., Callaway, Clifton W., Shin, Sang Do, Gräsner, Jan-Thorsten, Daya, Mohamud, Ma, Matthew Huei-Ming, Herlitz, Johan, Strömsöe, Anneli, Aufderheide, Tom P., Masterson, Siobhán, Wang, Henry, Christenson, Jim, Stiell, Ian, Vilke, Gary M., Idris, Ahamed, Nishiyama, Chika, Iwami, Taku, and Nichol, Graham

Published
2019
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14. 2015 revised Utstein-style recommended guidelines for uniform reporting of data from drowning-related resuscitation: An ILCOR advisory statement

Author

Idris, Ahamed H., Bierens, Joost J.L.M., Perkins, Gavin D., Wenzel, Volker, Nadkarni, Vinay, Morley, Peter, Warner, David S., Topjian, Alexis, Venema, Allart M., Branche, Christine M., Szpilman, David, Morizot-Leite, Luiz, Nitta, Masahiko, Løfgren, Bo, Webber, Jonathon, Gräsner, Jan-Thorsten, Beerman, Stephen B., Youn, Chun Song, Jost, Ulrich, Quan, Linda, Dezfulian, Cameron, Handley, Anthony J., and Hazinski, Mary Fran

Published
2017
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15. Prozesse

Author

Stehling, Heiko, Büscher, Andreas, Euteneier, Alexander, Gräsner, Jan-Thorsten, Wölfl, Christoph, Seidling, Hanna M., Stützle, Marion, Haefeli, Walter E., Gastmeier, Petra, Jürgensen, Jan Steffen, Schlesiger, Christian, Braun, Alban, and Euteneier, Alexander, editor

Published
2015
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17. What change in outcomes after cardiac arrest is necessary to change practice? Results of an international survey

Author

Nichol, Graham, Brown, Siobhan P., Perkins, Gavin D., Kim, Francis, Sterz, Fritz, Broeckel Elrod, Jo Ann, Mentzelopoulos, Spyros, Lyon, Richard, Arabi, Yaseen, Castren, Maaret, Larsen, Peter, Valenzuela, Terence, Graesner, Jan-Thorsten, Youngquist, Scott, Khunkhlai, Nalinas, Wang, Henry E., Ondrej, Franek, Sastrias, Juan Manuel Fraga, Barasa, Anders, and Sayre, Michael R.

Published
2016
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18. EuReCa ONE⿿27 Nations, ONE Europe, ONE Registry: A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe

Author

Kaufmann, Marc, Thaler, Markus, Maier, Martin, Prause, Gerhard, Trimmel, Helmut, de Longueville, Diane, Preseau, Thierry, Biarent, Dominique, Melot, Christian, Mpotos, Nicolas, Monsieurs, Koen, Van de Voorde, Patrick, Vanhove, Marie, Lievens, Pascale, Faniel, Mathias, Keleuva, Slobodanka, Lazarevic, Milan, Ujevic, Radmila Majhen, Devcic, Mato, Bardak, Branka, Barisic, Fabijan, Anticevic, Silvija Hunyadi, Georgiou, Marios, Truhláſ, Anatolij, Knor, Jiſí, Smržová, Eva, Sviták, Roman, Šín, Robin, Mokrejš, Petr, Lippert, Freddy K., Hallikainen, Juhana, Hoikka, Marko, Iirola, Timo, Jama, Timo, Jäntti, Helena, Jokisalo, Raimo, Jousi, Milla, Kirves, Hetti, Kuisma, Markku, Laine, Jukka, Länkimäki, Sami, Loikas, Petri, Lund, Vesa, Määttä, Teuvo, Nal, Heini, Niemelä, Heimo, Portaankorva, Petra, Pylkkänen, Marko, Sainio, Marko, Setälä, Piritta, Tervo, Jerry, Väyrynen, Taneli, Murgue, Davy, Champenois, Anne, Fournier, Marc, Meyran, Daniel, Tabary, Romain, Avondo, Aurélie, Gelin, Gelin, Simonnet, Bruno, Joly, Marc, Megy-Michoux, Isabelle, Paringaux, Xavier, Duffait, Yves, Vial, Michael, Segard, Julien, Narcisse, Sophie, Hamban, David, Hennache, Jonathan, Thiriez, Sylvain, Doukhan, Mathieu, Vanderstraeten, Carine, Morel, Jean-Charles, Majour, Gilles, Michenet, Corinne, Tritsch, Laurent, Dubesset, Marc, Peguet, Olivier, Pinero, David, Guillaumee, Fréderic, Fuster, Patrick, Ciacala, Jean-François, Jardel, Benoît, Letarnec, Jean-Yves, Goes, Frank, Gosset, Pierre, Vergne, Muriel, Bar, Christian, Branche, Fabienne, Prineau, Stevens, Lagadec, Steven, Cornaglia, Carole, Ursat, Cécile, Bertrand, Philippe, Agostinucci, Jean-Marc, Nadiras, Pierre, de Linares, Géraldine Gonzales, Jacob, Line, Revaux, François, Pernot, Thomas, Roudiak, Nathalie, Ricard-Hibon, Agnès, Villain-Coquet, Laurent, Beckers, Stefan, Hanff, Thomas, Strickmann, Bernd, Wiegand, Nicolai, Wilke, Petra, Sues, Harald, Bogatzki, Stefan, Baumeier, Wolfgang, Pohl, Kai, Werner, Bert, Fischer, Hans, Zeng, Torsten, Popp, Erik, Günther, Andreas, Hochberg, Andreas, Lechleuthner, Alex, Schewe, Jens-Christian, Lemke, Hans, Wranze-Bielefeld, Erich, Bohn, Andreas, Roessler, Markus, Naujoks, Frank, Sensen, Frank, Esser, Torben, Fischer, Matthias, Messelken, Martin, Rose, Christopher, Schlüter, Gabriele, Lotz, Wolfgang, Corzilius, Michael, Muth, Claus-Martin, Diepenseifen, Christian, Tauchmann, Björn, Birkholz, Torsten, Flemming, Andreas, Herrmann, Stefanie, Kreimeier, Uwe, Kill, Clemens, Marx, Frank, Schröder, Ralph, Lenz, Wolfgang, Botini, Glykeria, Grigorios, Barakos, Giannakoudakis, Nikolaos, Zervopoulos, Michail, Papangelis, Dimitrios, Petropoulou-Papanastasiou, Sofia, Liaskos, Themistoklis, Papanikolaou, Spyridon, Karabinis, Andreas, Zentay, Attila, ÿorsteinsson, Hólmgeir, Gilsdóttir, Anna, Birgisson, Svavar A., Guðmundsson, Fjölnir Freyr, Hreiðarsson, Hallgrímur, ÿrnason, Björgvin, Hermannsson, Hermann, Björnsson, Gísli, Friðriksson, Brynjar ÿór, Baldursson, Gunnar, Höskuldsson, ÿrmann, Valgarðsdottir, Jórunn, ÿsmundardóttir, Matthildur, Guðmundsson, Guðmundur, Kristjánsson, Hjörtur, ÿórarinsson, Eyþór Rúnar, Guðlaugsson, Jón, Skarphéðinsson, Sigurður, Peratoner, Alberto, Santarelli, Andrea, Sabetta, Cesare, Gordini, Giovanni, Sesana, Giovanni, Giudici, Riccardo, Savastano, Simone, Pellis, Tommaso, Beissel, Jean, Uhrig, Jean, Manderscheid, Tom, Klop, Marco, Stammet, Pascal, Koch, Marc, Welter, Philippe, Schuman, Robert, Bruins, Wendy, Amin, Hesam, Braa, Nina, Bratland, Staale, Buanes, Eirik Alnes, Draegni, Tomas, Johnsen, Knut Roar, Mathisen, Wenche Torunn, Oedegaarden, Terje, Oppedal, Marie, Reksten, Alf Stolt-Nielsen, Roedsand, Mats Eirik, Steen-Hansen, Jon Erik, Dyrda, Marta, Frejlich, Anna, MaciĿg, Sſawomir, Osadnik, Sonia, Weryk, Ireneusz, Mendonça, Eugénio, Freitas, Carlos, Cruz, Pinto, Caldeira, Carmo, Barros, José, Vale, Luis, Brazão, António, Jardim, Nuno, Rocha, Fernanda, Duarte, Ricardo, Fernandes, Nicodemos, Ramos, Pedro, Jardim, Margarida, Reis, Miguel, Ribeiro, Romulo, Zenha, Sérgio, Fernandes, Jorge, Francisco, Juan, Assis, David, Abreu, Fernanda, Freitas, Dinarte, Ribeiro, Leonardo, Azevedo, Paulo, Calafatinho, Débora, Jardim, Rui, Pestana, Aleixo, Faria, Rui, Oprita, Bogdan, Grasu, Alis, Nedelea, Paul, Sovar, Sorina, Agapi, Florin, KliĿkoviĿ, Aleksandar, LaziĿ, Aleksandra, NikoliĿ, Bogdan, Zivanovic, Bogdan, MartinoviĿ, Branislav, MilenkoviĿ, Dušan, Damir, HuseinoviĿ, Koprivica, Jovanka, JakšiĿ, Kornelija Horvat, Pajor, Margit, MiliĿ, Saša, VidoviĿ, Mirko, Glamoclija, Radojka Petrovic, Andjelic, Sladjana, Sladjana, Vlajovic, BabiĿ, Zlatko, Fišer, Zlatko, Androvic, Peter, Bajerovska, Lubica, Chabron, Miroslav, Dobias, Viliam, Havlikova, Eva, Horanova, Bozena, Kratochvilova, Renata, Kubova, Dana, Murgas, Jan, Patras, Juraj, Simak, Ladislav, Snarskij, Vladimir, Zaviaticova, Zuzana, Zuffova, Marcela, Roig, Francesc Escalada, Santos, Luis Sánchez, Sucunza, Alfredo Echarri, Cordero Torres, Juan A., Muñoz, Guadalupe Inza, del Valle, Marta Martínez, Rozalen, Isabel Ceniceros, Sánchez, Enrique Martín, Berlanga, María Victoria Raúl Canabal, Olalde, Karlos Ibarguren, Ruiz Azpiazu, José I., García-Ochoa, María José, López-Navarro, Rafael Zoyo, Adsuar Quesada, José M., Cortés Ramas, José A., Mellado Vergel, Francisco J., López Messa, Juan B., del Valle, Patricia Fernández, Anselmi, Luciano, Benvenuti, Breganzona Claudio, Batey, Nigel, Ambulance, Yorkshire, Booth, Scott, Bucher, Patricia, Deakin, Charles D., Duckett, Jay, Ji, Chen, Loughlin, Nancy, Lumley-Holmes, Jenny, Lynde, Jessica, Mersom, Frank, Ramsey, Carly, Robinson, Clare, Spaight, Robert, Dosanjh, Sukhdeep, Virdi, Gurkamal, Whittington, Andrew, Gräsner, Jan-Thorsten, Lefering, Rolf, Koster, Rudolph W., Masterson, Siobhán, Böttiger, Bernd W., Herlitz, Johan, Wnent, Jan, Tjelmeland, Ingvild B.M., Ortiz, Fernando Rosell, Maurer, Holger, Baubin, Michael, Mols, Pierre, HadžibegoviĿ, Irzal, Ioannides, Marios, Škulec, Roman, Wissenberg, Mads, Salo, Ari, Hubert, Hervé, Nikolaou, Nikolaos I., Lóczi, Gerda, Svavarsdóttir, Hildigunnur, Semeraro, Federico, Wright, Peter J., Clarens, Carlo, Pijls, Ruud, Cebula, Grzegorz, Correia, Vitor Gouveia, Cimpoesu, Diana, Raffay, Violetta, Trenkler, Stefan, Markota, Andrej, Strömsöe, Anneli, Burkart, Roman, Perkins, Gavin D., and Bossaert, Leo L.

Published
2016
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20. Cardiac Arrest and Cardiopulmonary Resuscitation Outcome Reports: Update of the Utstein Resuscitation Registry Templates for Out-of-Hospital Cardiac Arrest: A Statement for Healthcare Professionals From a Task Force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian and New Zealand Council on Resuscitation, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Southern Africa, Resuscitation Council of Asia); and the American Heart Association Emergency Cardiovascular Care Committee and the Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation

Author

Perkins, Gavin D., Jacobs, Ian G., Nadkarni, Vinay M., Berg, Robert A., Bhanji, Farhan, Biarent, Dominique, Bossaert, Leo L., Brett, Stephen J., Chamberlain, Douglas, de Caen, Allan R., Deakin, Charles D., Finn, Judith C., Gräsner, Jan-Thorsten, Hazinski, Mary Fran, Iwami, Taku, Koster, Rudolph W., Lim, Swee Han, Ma, Matthew Huei-Ming, McNally, Bryan F., Morley, Peter T., Morrison, Laurie J., Monsieurs, Koenraad G., Montgomery, William, Nichol, Graham, Okada, Kazuo, Ong, Marcus Eng Hock, Travers, Andrew H., and Nolan, Jerry P.

Published
2015
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21. European Resuscitation Council Guidelines for Resuscitation 2015: Section 1. Executive summary

Author

Khalifa, Gamal Eldin Abbas, Alfonzo, Annette, Arntz, Hans-Richard, Askitopoulou, Helen, Bellou, Abdelouahab, Beygui, Farzin, Biarent, Dominique, Bingham, Robert, Bierens, Joost J.L.M., Böttiger, Bernd W., Bossaert, Leo L., Brattebø, Guttorm, Brugger, Hermann, Bruinenberg, Jos, Cariou, Alain, Carli, Pierre, Cassan, Pascal, Castrén, Maaret, Chalkias, Athanasios F., Conaghan, Patricia, Deakin, Charles D., De Buck, Emmy D.J., Dunning, Joel, De Vries, Wiebe, Evans, Thomas R., Eich, Christoph, Gräsner, Jan-Thorsten, Greif, Robert, Hafner, Christina M., Handley, Anthony J., Haywood, Kirstie L., Hunyadi-Antičević, Silvija, Koster, Rudolph W., Lippert, Anne, Lockey, David J., Lockey, Andrew S., López-Herce, Jesús, Lott, Carsten, Maconochie, Ian K., Mentzelopoulos, Spyros D., Meyran, Daniel, Monsieurs, Koenraad G., Nikolaou, Nikolaos I., Nolan, Jerry P., Olasveengen, Theresa, Paal, Peter, Pellis, Tommaso, Perkins, Gavin D., Rajka, Thomas, Raffay, Violetta I., Ristagno, Giuseppe, Rodríguez-Núñez, Antonio, Roehr, Charles Christoph, Rüdiger, Mario, Sandroni, Claudio, Schunder-Tatzber, Susanne, Singletary, Eunice M., Skrifvars, Markus B., Smith, Gary B., Smyth, Michael A., Soar, Jasmeet, Thies, Karl-Christian, Trevisanuto, Daniele, Truhlář, Anatolij, Vandekerckhove, Philippe G., de Voorde, Patrick Van, Sunde, Kjetil, Urlesberger, Berndt, Wenzel, Volker, Wyllie, Jonathan, Xanthos, Theodoros T., and Zideman, David A.

Published
2015
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22. Part 4: Advanced life support: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations

Author

Andersen, Lars W., Berg, Katherine M., Sandroni, Claudio, Lin, Steve, Lavonas, Eric J., Golan, Eyal, Alhelail, Mohammed A., Chopra, Amit, Cocchi, Michael N., Cronberg, Tobias, Dainty, Katie N., Drennan, Ian R., Fries, Michael, Geocadin, Romergryko G., Gräsner, Jan-Thorsten, Granfeldt, Asger, Heikal, Sarah, Kudenchuk, Peter J., Lagina, Anthony T., III, Løfgren, Bo, Mhyre, Jill, Monsieurs, Koenraad G., Mottram, Allan R., Pellis, Tommaso, Reynolds, Joshua C., Ristagno, Giuseppe, Severyn, Fred A., Skrifvars, Markus, Stacey, William C., Sullivan, Jonathon, Todhunter, Sarah L., Vissers, Gino, West, Stephen, Wetsch, Wolfgang A., Wong, Natalie, Xanthos, Theodoros, Zelop, Carolyn M., Zimmerman, Janice, Soar, Jasmeet, Callaway, Clifton W., Aibiki, Mayuki, Böttiger, Bernd W., Brooks, Steven C., Deakin, Charles D., Donnino, Michael W., Drajer, Saul, Kloeck, Walter, Morley, Peter T., Morrison, Laurie J., Neumar, Robert W., Nicholson, Tonia C., Nolan, Jerry P., Okada, Kazuo, O’Neil, Brian J., Paiva, Edison F., Parr, Michael J., Wang, Tzong-Luen, and Witt, Jonathan

Published
2015
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23. Part 3: Adult basic life support and automated external defibrillation: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations

Author

Bierens, Joost J.L.M., Bourdon, Emmanuelle, Brugger, Hermann, Buick, Jason E., Charette, Manya L., Chung, Sung Phil, Couper, Keith, Daya, Mohamud R., Drennan, Ian R., Gräsner, Jan-Thorsten, Idris, Ahamed H., Lerner, E. Brooke, Lockhat, Husein, Løfgren, Bo, McQueen, Carl, Monsieurs, Koenraad G., Mpotos, Nicolas, Orkin, Aaron M., Quan, Linda, Raffay, Violetta, Reynolds, Joshua C., Ristagno, Giuseppe, Scapigliati, Andrea, Vadeboncoeur, Tyler F., Wenzel, Volker, Yeung, Joyce, Perkins, Gavin D., Travers, Andrew H., Berg, Robert A., Castren, Maaret, Considine, Julie, Escalante, Raffo, Gazmuri, Raul J., Koster, Rudolph W., Lim, Swee Han, Nation, Kevin J., Olasveengen, Theresa M., Sakamoto, Tetsuya, Sayre, Michael R., Sierra, Alfredo, Smyth, Michael A., Stanton, David, and Vaillancourt, Christian

Published
2015
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24. European Resuscitation Council Guidelines for Resuscitation 2015: Section 2. Adult basic life support and automated external defibrillation

Author

Bossaert, Leo L., Caballero, Antonio, Cassan, Pascal, Granja, Cristina, Sandroni, Claudio, Zideman, David A., Nolan, Jerry P., Maconochie, Ian, Greif, Robert, Perkins, Gavin D., Handley, Anthony J., Koster, Rudolph W., Castrén, Maaret, Smyth, Michael A., Olasveengen, Theresa, Monsieurs, Koenraad G., Raffay, Violetta, Gräsner, Jan-Thorsten, Wenzel, Volker, Ristagno, Giuseppe, and Soar, Jasmeet

Published
2015
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27. An international collaborative study to co-produce a patient-reported outcome measure of cardiac arrest survivorship and health-related quality of life (CASHQoL): A protocol for developing the long-form measure

Author

Haywood, Kirstie L., primary, Southern, Charlotte, additional, Tutton, Elizabeth, additional, Swindell, Paul, additional, Ellard, David, additional, Pearson, Nathan A., additional, Parsons, Helen, additional, Couper, Keith, additional, Dainty, Katie N., additional, Agarwal, Sachin, additional, Perkins, Gavin D., additional, Arestedt, Kristofer, additional, Aves, Theresa, additional, Bray, Janet, additional, Brookes, Anne, additional, Callaway, Clifton, additional, Castren, Maaret, additional, Ong, Marcus Eng Hock, additional, Gellis, Katrysha, additional, Goossens, Paulien H., additional, Graesner, Jan-Thorsten, additional, Hartley, Angela, additional, Hoadley, Rob, additional, Israelsson, Johan, additional, Jeffrey, David, additional, Joshi, Vicky, additional, Keeble, Thomas R., additional, Lilja, Gisela, additional, Long, John, additional, Mion, Marco, additional, Morrison, Laurie J., additional, Moulaert, Veronique R.M., additional, Playford, Diane, additional, Sawyer, Kelly, additional, Semeraro, Federico, additional, Smith, Karen, additional, Williams, Barry, additional, and Wylie, Jasmine, additional

Published
2022
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28. Apples to apples or apples to oranges? International variation in reporting of process and outcome of care for out-of-hospital cardiac arrest

Author

Nishiyama, Chika, Brown, Siobhan P., May, Susanne, Iwami, Taku, Koster, Rudolph W., Beesems, Stefanie G., Kuisma, Markku, Salo, Ari, Jacobs, Ian, Finn, Judith, Sterz, Fritz, Nürnberger, Alexander, Smith, Karen, Morrison, Laurie, Olasveengen, Theresa M., Callaway, Clifton W., Shin, Sang Do, Gräsner, Jan-Thorsten, Daya, Mohamud, Ma, Matthew Huei-Ming, Herlitz, Johan, Strömsöe, Anneli, Aufderheide, Tom P., Masterson, Siobhán, Wang, Henry, Christenson, Jim, Stiell, Ian, Davis, Dan, Huszti, Ella, and Nichol, Graham

Published
2014
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32. Higher chance of survival in patients with out-of-hospital cardiac arrest attributed to poisoning

Author

Hueser, Christoph, Baumgaertel, Matthias, Ristau, Patrick, Wnent, Jan, Suarez, Victor, Hackl, Matthias Johannes, Graesner, Jan-Thorsten, Seewald, Stephan, Hueser, Christoph, Baumgaertel, Matthias, Ristau, Patrick, Wnent, Jan, Suarez, Victor, Hackl, Matthias Johannes, Graesner, Jan-Thorsten, and Seewald, Stephan

Abstract

Aim of the study: Description and comparison of cohort characteristics and outcome of adult patients with out-of-hospital cardiac arrest (OHCA) attributed to poisoning (P-OHCA) versus patients with OHCA attributed to other medical causes (NP-OHCA). Methods: We included all patients who received cardiopulmonary resuscitation after OHCA between January 2011 and December 2020 from German emergency medical services with good data quality in the German Resuscitation Registry. Exclusion criteria: patients < 18 years of age or OHCA attributed to trauma, drowning, intracranial bleeding or exsanguination. Results: Patients with P-OHCA (n = 574) were significantly younger compared to NP-OHCA (n = 40,146) (median age of 43 (35-54) years vs. 73 (62-82) years; p < 0.001). Cardiac arrest in P-OHCA patients was significantly less often witnessed by bystanders (41.8 % vs. 66.2 %, p < 0.001). Asystole was the predominant initial rhythm in P-OHCA patients (73.5% vs. 53.7%, p < 0.001) while ventricular fibrillation (VF) and pulseless electrical activity (PEA) were less common (9.2% vs. 25.1% and 16.2 % vs. 20.5%, p < 0.001). P-OHCA had a higher chance of survival with good neurological outcome at hospital discharge (15.2 vs. 8.8 % p < 0.001) and poisoning was an independent protective prognostic factor in multivariate analysis (OR 2.47, 95%-CI [1.71-3.57]). P-OHCA patients with initial PEA survival with good neurological outcome was comparable to initial VF (34.3 % vs. 37.7%). Conclusion: Patients in the P-OHCA group had a significantly higher chance of survival with good neurological outcome and PEA as initial rhythm was as favourable as initial VF. Therefore, in P-OHCA patients resuscitation efforts should be extended.

Published
2022

35. Kurzfassung : Leitlinien des European Resuscitation Council 2021

Author

Perkins, Gavin D., Graesner, Jan-Thorsten, Semeraro, Federico, Olasveengen, Theresa, Soar, Jasmeet, Lott, Carsten, Van de Voorde, Patrick, Madar, John, Zideman, David, Mentzelopoulos, Spyridon, Bossaert, Leo, Greif, Robert, Monsieurs, Koen, Svavarsdottir, Hildigunnur, Nolan, Jerry P., and Autoren Leitlinien European Resuscitation Council

Subjects
education, Human medicine
Abstract

Informed by a series of systematic reviews, scoping reviews and evidence updates from the International Liaison Committee on Resuscitation, the 2021 European Resuscitation Council Guidelines present the most up to date evidence-based guidelines for the practice of resuscitation across Europe. The guidelines cover the epidemiology of cardiac arrest; the role that systems play in saving lives, adult basic life support, adult advanced life support, resuscitation in special circumstances, post resuscitation care, first aid, neonatal life support, paediatric life support, ethics and education.

Published
2021

36. Executive summary European Resuscitation Council Guidelines 2021

Author

Perkins, Gavin D. Graesner, Jan-Thorsten Semeraro, Federico and Olasveengen, Theresa Soar, Jasmeet Lott, Carsten Van de Voorde, Patrick Madar, John Zideman, David Mentzelopoulos, Spyridon Bossaert, Leo Greif, Robert Monsieurs, Koen and Svavarsdottir, Hildigunnur Nolan, Jerry P. Autoren Leitlinien European Resusc

Subjects
education
Abstract

Informed by a series of systematic reviews, scoping reviews and evidence updates from the International Liaison Committee on Resuscitation, the 2021 European Resuscitation Council Guidelines present the most up to date evidence-based guidelines for the practice of resuscitation across Europe. The guidelines cover the epidemiology of cardiac arrest; the role that systems play in saving lives, adult basic life support, adult advanced life support, resuscitation in special circumstances, post resuscitation care, first aid, neonatal life support, paediatric life support, ethics and education.

Published
2021

37. Epidemiology of cardiac arrest in Europe European Resuscitation Council Guidelines 2021

Author

Graesner, Jan-Thorsten, Herlitz, Johan, Tjelmeland, Ingvild B. M., Wnent, Jan, Masterson, Siobhan, Lilja, Gisela, Bein, Berthold, Boettiger, Bernd W., Rosell-Ortiz, Fernando, Nolan, Jerry P., Bossaert, Leo, Perkins, Gavin D., Graesner, Jan-Thorsten, Herlitz, Johan, Tjelmeland, Ingvild B. M., Wnent, Jan, Masterson, Siobhan, Lilja, Gisela, Bein, Berthold, Boettiger, Bernd W., Rosell-Ortiz, Fernando, Nolan, Jerry P., Bossaert, Leo, and Perkins, Gavin D.

Abstract

In this section of the European Resuscitation Council Guidelines 2021, key information on the epidemiology and outcome of in- and out-of-hospital cardiac arrest are presented. Key contributions from the European Registry of Cardiac Arrest (EuReCa) collaboration are highlighted. Recommendations are presented to enable health systems to develop registries as a platform for quality improvement and to provide support for health system planning and responses to cardiac arrest.

Published
2021

38. Clinical paper To ventilate or not to ventilate during bystander CPR - A EuReCa TWO analysis

Author

Wnent, Jan, Tjelmeland, Ingvild, Lefering, Rolf, Koster, Rudolph W., Maurer, Holger, Masterson, Siobhan, Herlitz, Johan, Boettiger, Bernd W., Ortiz, Fernando Rosell, Perkins, Gavin D., Bossaert, Leo, Moertl, Maximilian, Mols, Pierre, Hadibegovic, Irzal, Truhlar, Anatolij, Salo, Ari, Baert, Valentine, Nagy, Eniko, Cebula, Grzegorz, Raffay, Violetta, Trenkler, Stefan, Markota, Andrej, Stroemsoe, Anneli, Graesner, Jan-Thorsten, Wnent, Jan, Tjelmeland, Ingvild, Lefering, Rolf, Koster, Rudolph W., Maurer, Holger, Masterson, Siobhan, Herlitz, Johan, Boettiger, Bernd W., Ortiz, Fernando Rosell, Perkins, Gavin D., Bossaert, Leo, Moertl, Maximilian, Mols, Pierre, Hadibegovic, Irzal, Truhlar, Anatolij, Salo, Ari, Baert, Valentine, Nagy, Eniko, Cebula, Grzegorz, Raffay, Violetta, Trenkler, Stefan, Markota, Andrej, Stroemsoe, Anneli, and Graesner, Jan-Thorsten

Abstract

Background: Survival after out-of-hospital cardiac arrest (OHCA) is still low. For every minute without resuscitation the likelihood of survival decreases. One critical step is initiation of immediate, high quality cardiopulmonary resuscitation (CPR). The aim of this subgroup analysis of data collected for the European Registry of Cardiac Arrest Study number 2 (EuReCa TWO) was to investigate the association between OHCA survival and two types of bystander CPR namely: chest compression only CPR (CConly) and CPR with chest compressions and ventilations (FullCPR). Method: In this subgroup analysis of EuReCa TWO, all patients who received bystander CPR were included. Outcomes were return of spontaneous circulation and survival to 30-days or hospital discharge. A multilevel binary logistic regression analysis with survival as the dependent variable was performed. Results: A total of 5884 patients were included in the analysis, varying between countries from 21 to 1444. Survival was 320 (8%) in the CConly group and 174 (13%) in the FullCPR group. After adjustment for age, sex, location, rhythm, cause, time to scene, witnessed collapse and country, patients who received FullCPR had a significantly higher survival rate when compared to those who received CConly (adjusted odds ration 1.46, 95% confidence interval 1.17-1.83). Conclusion: In this analysis, FullCPR was associated with higher survival compared to CConly. Guidelines should continue to emphasise the importance of compressions and ventilations during resuscitation for patients who suffer OHCA and CPR courses should continue to teach both.

Published
2021

39. European Resuscitation Council Guidelines 2021 Epidemiology of cardiac arrest in Europe

Author

Graesner, Jan-Thorsten, Herlitz, Johan, Tjelmeland, Ingvild B. M., Wnent, Jan, Masterson, Siobhan, Lilja, Gisela, Bein, Berthold, Boettiger, Bernd W., Rosell-Ortiz, Fernando, Nolan, Jerry P., Bossaert, Leo, Perkins, Gavin D., Graesner, Jan-Thorsten, Herlitz, Johan, Tjelmeland, Ingvild B. M., Wnent, Jan, Masterson, Siobhan, Lilja, Gisela, Bein, Berthold, Boettiger, Bernd W., Rosell-Ortiz, Fernando, Nolan, Jerry P., Bossaert, Leo, and Perkins, Gavin D.

Abstract

In this section of the European Resuscitation Council Guidelines 2021, key information on the epidemiology and outcome of in and out of hospital cardiac arrest are presented. Key contributions from the European Registry of Cardiac Arrest (EuReCa) collaboration are highlighted. Recommendations are presented to enable health systems to develop registries as a platform for quality improvement and to inform health system planning and responses to cardiac arrest.

Published
2021

43. Survival after out-of-hospital cardiac arrest in Europe - Results of the EuReCa TWO study

Author

Graesner, Jan-Thorsten, Wnent, Jan, Herlitz, Johan, Perkins, Gavin D., Lefering, Rolf, Tjelmeland, Ingvild, Koster, Rudolph W., Masterson, Siobhan, Rossell-Ortiz, Fernando, Maurer, Holger, Boettiger, Bernd W., Moertl, Maximilian, Mols, Pierre, Alihodic, Hajriz, Hadibegovic, Irzal, Ioannides, Marios, Truhlar, Anatolij, Wissenberg, Mads, Salo, Ari, Escutnaire, Josephine, Nikolaou, Nikolaos, Nagy, Eniko, Jonsson, Bergthor Steinn, Wright, Peter, Semeraro, Federico, Clarens, Carlo, Beesems, Steffie, Cebula, Grzegorz, Correia, Vitor H., Cimpoesu, Diana, Raffay, Violetta, Trenkler, Stefan, Markota, Andrej, Stroemsoee, Anneli, Burkart, Roman, Booth, Scott, Bossaert, Leo, Graesner, Jan-Thorsten, Wnent, Jan, Herlitz, Johan, Perkins, Gavin D., Lefering, Rolf, Tjelmeland, Ingvild, Koster, Rudolph W., Masterson, Siobhan, Rossell-Ortiz, Fernando, Maurer, Holger, Boettiger, Bernd W., Moertl, Maximilian, Mols, Pierre, Alihodic, Hajriz, Hadibegovic, Irzal, Ioannides, Marios, Truhlar, Anatolij, Wissenberg, Mads, Salo, Ari, Escutnaire, Josephine, Nikolaou, Nikolaos, Nagy, Eniko, Jonsson, Bergthor Steinn, Wright, Peter, Semeraro, Federico, Clarens, Carlo, Beesems, Steffie, Cebula, Grzegorz, Correia, Vitor H., Cimpoesu, Diana, Raffay, Violetta, Trenkler, Stefan, Markota, Andrej, Stroemsoee, Anneli, Burkart, Roman, Booth, Scott, and Bossaert, Leo

Abstract

Background: The epidemiology and outcome after out-of-hospital cardiac arrest (OHCA) varies across Europe. Following on from EuReCa ONE, the aim of this study was to further explore the incidence of and outcomes from OHCA in Europe and to improve understanding of the role of the bystander. Methods: This prospective, multicentre study involved the collection of registry-based data over a three-month period (1st October 2017 to 31st December 2017). The core study dataset complied with the Utstein-style. Primary outcomes were return of spontaneous circulation (ROSC) and survival to hospital admission. Secondary outcome was survival to hospital discharge. Results: All 28 countries provided data, covering a total population of 178,879,118. A total of 37,054 OHCA were confirmed, with CPR being started in 25,171 cases. The bystander cardiopulmonary resuscitation (CPR) rate ranged from 13% to 82% between countries (average: 58%). In one third of cases (33%) ROSC was achieved and 8% of patients were discharged from hospital alive. Survival to hospital discharge was higher in patients when a bystander performed CPR with ventilations, compared to compression-only CPR (14% vs. 8% respectively). Conclusion: In addition to increasing our understanding of the role of bystander CPR within Europe, EuReCa TWO has confirmed large variation in OHCA incidence, characteristics and outcome, and highlighted the extent to which OHCA is a public health burden across Europe. Unexplained variation remains and the EuReCa network has a continuing role to play in improving the quality management of resuscitation.

Published
2020

44. Application of mechanical cardiopulmonary resuscitation devices and their value in out-of-hospital cardiac arrest: A retrospective analysis of the German Resuscitation Registry

Author

Seewald, Stephan, Obermaier, Manuel, Lefering, Rolf, Bohn, Andreas, Georgieff, Michael, Muth, Claus-Martin, Graesner, Jan-Thorsten, Masterson, Siobhan, Scholz, Jens, Wnent, Jan, Seewald, Stephan, Obermaier, Manuel, Lefering, Rolf, Bohn, Andreas, Georgieff, Michael, Muth, Claus-Martin, Graesner, Jan-Thorsten, Masterson, Siobhan, Scholz, Jens, and Wnent, Jan

Abstract

Background Cardiac arrest is an event with a limited prognosis which has not substantially changed since the first description of cardiopulmonary resuscitation (CPR) in 1960. A promising new treatment approach may be mechanical CPR devices (mechanical CPR). Methods In a retrospective analysis of the German Resuscitation Registry between 2007-2014, we examined the outcome after using mechanical CPR on return of spontaneous circulation (ROSC) in adults with out-of-hospital cardiac arrest (OHCA). We compared mechanical CPR to manual CPR. According to preclinical risk factors, we calculated the predicted ROSC-after-cardiac-arrest (RACA) score for each group and compared it to the rate of ROSC observed. Using multivariate analysis, we adjusted the influence of the devices' application on ROSC for epidemiological factors and therapeutic measures. Results We included 19,609 patients in the study. ROSC was achieved in 51.5% of the mechanical CPR group (95%-CI 48.2-54.8%, ROSC expected 42.5%) and in 41.2% in the manual CPR group (95%-CI 40.4-41.9%, ROSC expected 39.2%). After multivariate adjustment, mechanical CPR was found to be an independent predictor of ROSC (OR 1.77; 95%-CI 1.48-2.12). Duration of CPR is a key determinant for achieving ROSC. Conclusions Mechanical CPR was associated with an increased rate of ROSC and when adjusted for risk factors appeared advantageous over manual CPR. Mechanical CPR devices may increase survival and should be considered in particular circumstances according to a physicians' decision, especially during prolonged resuscitation.

Published
2019

45. Recommendations for extracorporeal cardiopulmonary resuscitation (eCPR): consensus statement of DGIIN, DGK, DGTHG, DGfK, DGNI, DGAI, DIVI and GRC

Author

Michels, Guido, Wengenmayer, Tobias, Hagl, Christian, Dohmen, Christian, Boettiger, Bernd W., Bauersachs, Johann, Markewitz, Andreas, Bauer, Adrian, Graesner, Jan-Thorsten, Pfister, Roman, Ghanem, Alexander, Busch, Hans-Joerg, Kreimeier, Uwe, Beckmann, Andreas, Fischer, Matthias, Kill, Clemens, Janssens, Uwe, Kluge, Stefan, Born, Frank, Hoffmeister, Hans Martin, Preusch, Michael, Boeken, Udo, Riessen, Reimer, Thiele, Holger, Michels, Guido, Wengenmayer, Tobias, Hagl, Christian, Dohmen, Christian, Boettiger, Bernd W., Bauersachs, Johann, Markewitz, Andreas, Bauer, Adrian, Graesner, Jan-Thorsten, Pfister, Roman, Ghanem, Alexander, Busch, Hans-Joerg, Kreimeier, Uwe, Beckmann, Andreas, Fischer, Matthias, Kill, Clemens, Janssens, Uwe, Kluge, Stefan, Born, Frank, Hoffmeister, Hans Martin, Preusch, Michael, Boeken, Udo, Riessen, Reimer, and Thiele, Holger

Abstract

Extracorporeal cardiopulmonary resuscitation (eCPR) may be considered as a rescue attempt for highly selected patients with refractory cardiac arrest and potentially reversible aetiology. Currently, there are no randomised, controlled studies on eCPR. Thus, prospective validated predictors of benefit and outcome are lacking. Currently, selection criteria and procedure techniques differ across hospitals and standardised algorithms are lacking. Based on expert opinion, the present consensus statement provides a first standardised treatment algorithm for eCPR.

Published
2019

48. The Effect of Ambulance Response Time on Survival Following Out-of-Hospital Cardiac Arrest An Analysis from the German Resuscitation Registry

Author

Buerger, Andreas, Wnent, Jan, Bohn, Andreas, Jantzen, Tanja, Brenner, Sigrid, Lefering, Rolf, Seewald, Stephan, Graesner, Jan-Thorsten, Fischer, Matthias, Buerger, Andreas, Wnent, Jan, Bohn, Andreas, Jantzen, Tanja, Brenner, Sigrid, Lefering, Rolf, Seewald, Stephan, Graesner, Jan-Thorsten, and Fischer, Matthias

Abstract

Background: Out of hospital cardiac arrest (OHCA) is one of the more common causes of death in Germany. Ambulance response time is an important planning parameter for emergency medical services (EMS) systems. We studied the effect of ambulance response time on survival after resuscitation from OHCA. Methods: We analyzed data from the German Resuscitation Registry for the years 2010-2016. First, we used a multivariate logistic regression analysis to determine the effect of ambulance response time (defined as the interval from the alarm to the arrival of the first rescue vehicle) on the hospital-discharge rate (in percent), depending on various factors, including resuscitation by bystanders. Second, we compared faster and slower EMS systems (defined as those arriving on the scene within 8 minutes in more than 75% of cases or in <= 75% of cases) with respect to the frequency of resuscitation and the number of surviving patients. Results: Our analysis of data from a total of 10 853 patients in the logistical regression model revealed that the rate of hospital discharge was significantly affected by the ambulance response time, bystander resuscitation, past medical history, age, witnessed vs. unwitnessed collapse, the initial heart rhythm, and the site of the collapse. The success of resuscitation was inversely related to the ambulance response time; thus, among patients who did not receive bystander resuscitation, the discharge rate declined from 12.9% at a mean response time of 1 minute and 10 seconds to 6.4% at a mean response time of 9 minutes and 47 seconds. Twelve faster EMS systems and 13 slower ones were identified, with a total of 9669 and 7865 resuscitated patients, respectively. The faster EMS systems initiated resuscitation more frequently and also had a higher discharge rate with good neurological outcome in proportion to the population of the catchment area (7.7 versus 5.6 persons per 100 000 population per year, odds ratio [OR] 0.72, 95% confidence interva

Published
2018

49. EuReCa TWO - A prospective observational analysis over three month in 29 cardiac arrest and resuscitation registries in 29 European countries - The EuReCa TWO study protocol

Author

Wnent, Jan, Masterson, Siobhan, Graesner, Jan-Thorsten, Boettiger, Bernd W., Eggeling, Johanna, Herlitz, Johan, Koster, Rudolph W., Lefering, Rolf, Maurer, Holger, Rosell Ortiz, Fernando, Perkins, Gavin D., Tjelmeland, Ingvild, Bossaert, Leo, Amsterdam Cardiovascular Sciences, Cardiology, and ACS - Heart failure & arrhythmias

Subjects
Human medicine
Abstract

EuReCa ONE was a one-month survey of epidemiology, treatment and outcome of patients suffering an out-of hospital cardiac arrest (OHCA), across 27 European nations, in October 2014. The EuReCa ONE study showed a high degree of variation in incidence and outcome across Europe and raised questions about the cause of these variations. For example, different interpretations of the term 'bystander CPR' was noted, confirmed by a subsequent European survey. The need to further understand the cause of variation led to the establishment of the EuReCa TWO project. EuReCa TWO has three primary aims: 1) Expand the EuReCa network; 2) Improve the understanding of the role, age and gender profile of bystanders in OHCA in Europe; 3) Generate estimates of European OHCA incidence and outcome for all patients as well as subgroups that make up a small proportion of overall cases at national level, e.g. traumatic aetiology, patients transferred to hospital with ongoing CPR. In order to achieve these aims, the following objectives will be fulfilled: encourage participating countries to aim for national data collection and encourage additional countries to participate in the study; increase the data collection period in order to provide more robust estimates of incidence, management and outcome; identify consistency and variation in the use of the term 'bystander CPR'; describe the incidence of 'bystander CPR' and its influence on OHCA outcome. With 29 countries now part of the EuReCa 'family', the EuReCa TWO study provides an expanded Utsteinbased dataset, data collection tool over a three-month data collection period for all participating countries. The EuReCa TWO study is registered by ClinicalTrials.gov

Published
2017

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