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1. Avaliação da relação proteína-creatinina urinária em gatos com doença renal crônica

Author

Maria Cristina N. Castro, Gracy C.G. Marcello, Nayro X. Alencar, and Ana Maria R. Ferreira

Subjects
Doenças de gatos, doença renal crônica, relação proteína-creatinina urinária, Diseases of cats, chronic renal disease, urinary protein/creatinine ratio, Veterinary medicine, SF600-1100
Abstract

Doença renal crônica (DRC) é a forma mais comum de doença renal em gatos. Vários fatores têm sido citados como importantes na progressão da doença, dentre eles a proteinúria. A relação proteína-creatinina (RPC) urinária em uma única amostra de urina apresenta boa correlação com a perda de proteína urinária em 24 horas. O objetivo dessa investigação foi determinar a RPC urinária em gatos com DRC adquirida naturalmente. A determinação da RPC foi realizada em nove gatos saudáveis (Grupo I) e em trinta gatos com DRC (Grupo II). Os gatos do Grupo I apresentaram RPC de 0,16±0,10 e os gatos do Grupo II apresentaram RPC de 0,53± 0,59. No Grupo II encontrou-se correlação positiva e significante da RPC com o nível de creatinina sérica. Os resultados deste estudo demonstram que a RPC urinária em gatos com DRC é bastante variável e que, à semelhança do que já havia sido previamente descrito, aproximadamente um terço dos gatos com DRC são considerados proteinúricos segundo critérios estabelecidos pela literatura (RPC urinária >0,4).Chronic renal disease (CRD) is the most common form of renal disease in cats. Several factors contribute to disease progression. Proteinuria is an important marker of renal disease progression. The protein-creatinine ratio in a single urine sample correlates well with urinary protein loss in 24 hours. The aim of this investigation was to determine the urine protein-creatinine (UPC) ratio in cats with natural acquired chronic renal disease. The UPC ratio was performed in nine clinically normal cats and in 30 cats with chronic renal disease. Mean UPC ratio in normal cats was 0.16±0.10, and mean UPC ratio in the cats with chronic renal disease was 0.53± 0.59. In the group with renal disease there was positive correlation between UPC ratio and serum creatinine levels. The results obtained from this study demonstrate that UPC ratio in cats with CRD is variable and that, in accordance to what has previously been described, approximately one third of the cats with CRD are considered proteinuric according to the criteria established in literature (UPC ratio > 0.4).

Published
2009
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2. Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats

Author

Stelio Pacca Loureiro Luna, Gracy C.G. Marcello, Carlos Roberto Padovani, Juliana Tabarelli Brondani, and Universidade Estadual Paulista (UNESP)

Subjects
Platelet Aggregation, Ovariectomy, Analgesic, Naphthalenes, Postoperative Hemorrhage, Placebo, Cat Diseases, Hysterectomy, chemistry.chemical_compound, Double-Blind Method, Bleeding time, medicine, Animals, Small Animals, Tramadol, Pain Measurement, Analgesics, Pain, Postoperative, medicine.diagnostic_test, business.industry, Vedaprofen, Perioperative, Analgesics, Non-Narcotic, Treatment Outcome, chemistry, Anesthesia, Vomiting, Cats, Drug Therapy, Combination, Female, medicine.symptom, Propionates, Gastrointestinal function, business, medicine.drug
Abstract

Made available in DSpace on 2022-04-28T20:51:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-06-01 A randomized double blind and placebo controlled design was used to investigate the hemostatic, biochemical, gastrointestinal and behavioral effects of pre- and postoperative administration of vedaprofen 0.5 mg/kg PO (V), tramadol 2 mg/kg SC (T), their association (VT) or placebo (P) in 40 adult female cats (3.0 ± 0.32 kg; 1.8 ± 0.7 years) distributed in groups of 10. Platelet aggregation and bleeding time were measured before and 52 h after ovariohysterectomy. Serum urea, creatinine, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transferase concentrations were measured before and 7 days postoperatively. The occurrence of vomiting, frequency and consistency of feces, and behavior were observed for 7 days postoperatively. Morphine (0.5 mg/kg, IM) was used as rescue analgesic. Laboratory variables did not change. Vomiting was observed only after morphine administration. Mild euphoria was observed in T and VT. The perioperative use of vedaprofen and/or tramadol did not modify the hemostatic, biochemical and gastrointestinal function in cats. © 2009 ESFM and AAFP. Department of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science São Paulo State University, Botucatu, São Paulo Department of Biostatistics Institute of Biosciences São Paulo State University, Botucatu, São Paulo Department of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science São Paulo State University, Botucatu, São Paulo Department of Biostatistics Institute of Biosciences São Paulo State University, Botucatu, São Paulo

Published
2008

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