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11 results on '"Graceffa, Pietro"'

2. Efficacy of 1 L polyethylene glycol plus ascorbate versus 4 L polyethylene glycol in split-dose for colonoscopy cleansing in out and inpatient: A multicentre, randomized trial (OVER 2019)

Author

Vassallo, Roberto, Maida, Marcello, Zullo, Angelo, Venezia, Ludovica, Montalbano, Luigi, Mitri, Roberto Di, Peralta, Marco, Virgilio, Clara, Pallio, Socrate, Pluchino, Dario, D'amore, Fabio, Santagati, Alessio, Sinagra, Emanuele, Graceffa, Pietro, Nicosia, Giuseppe, Camilleri, Salvatore, Gibiliaro, Gerlando, Abdelhadi, Yasmin, Rancatore, Gabriele, Scalisi, Giuseppe, Melita, Giuseppinella, Magnano, Antonio, Conoscenti, Giuseppe, and Facciorusso, Antonio

Published
2024
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4. What is the benefit of prophylaxis to prevent HBV reactivation in HBsAg‐negative anti‐HBc‐positive patients? Meta‐analysis and decision curve analysis.

Author

Celsa, Ciro, Rizzo, Giacomo E. M., Di Maria, Gabriele, Enea, Marco, Vaccaro, Marco, Rancatore, Gabriele, Graceffa, Pietro, Falco, Giuseppe, Petta, Salvatore, Cabibbo, Giuseppe, Calvaruso, Vincenza, Craxì, Antonio, Cammà, Calogero, Di Marco, Vito, Rizzo, Chiara, Destro Castaniti, Giulia Maria, Di Stefano, Vincenzo, Madonia, Giorgio, Tilotta, Giovanna, and Agliastro, Giuseppe

Subjects
DISEASE risk factors, HEPATITIS B virus, DECISION making, CANCER patients, THERAPEUTICS
Abstract

Background and Aims: Patients with overt or occult hepatitis B virus (HBV) infection receiving immunosuppressive treatments have a wide risk of HBV reactivation (HBVr). We performed meta‐analysis with decision curve analyses (DCA) to estimate the risk of HBVr in HBsAg‐negative anti‐HBc‐positive patients naïve to nucleos(t)ide analogues (NAs) receiving immunosuppressive treatments. Approach and Results: Studies were identified through literature search until October 2022. Pooled estimates were obtained using random‐effects model. Subgroup analyses were performed according to underlying disease and immunosuppressive treatments. DCA was used to identify the threshold probability associated with the net benefit of antiviral prophylaxis in HBsAg‐negative anti‐HBc‐positive patients. We selected 68 studies (40 retrospective and 28 prospective), including 8034 patients with HBsAg negative anti‐HBc positive. HBVr was 4% (95% CI 3%–6%) in HBsAg‐negative anti‐HBc‐positive patients, with a significantly high heterogeneity (I2 69%; p <.01). The number‐needed‐to‐treat (NNT) by DCA ranged from 8 to 24 for chemotherapy plus rituximab, from 12 to 24 for targeted therapies in cancer patients and from 13 to 39 for immune‐mediated diseases. Net benefit was small for monoclonal antibodies. Conclusions: Our DCA in HBsAg‐negative anti‐HBc‐positive patients provided evidence that NA prophylaxis is strongly recommended in patients treated with chemotherapy combined with rituximab and could be appropriate in patients with cancer treated with targeted therapies and in patients with immune‐mediated diseases. Finally, in patients with cancer treated with monoclonal antibodies or with chemotherapy without rituximab, the net benefit is even lower. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Risk factors for viral reactivation in patients with overt or occult HepatitisB Virus infection receiving immunosuppressive treatments: a systematic review and meta-analysis

Author

Celsa, Ciro, primary, Maria Rizzo, Giacomo Emanuele, additional, Rancatore, Gabriele, additional, Graceffa, Pietro, additional, Falco, Giuseppe, additional, Di Maria, Gabriele, additional, Vaccaro, Marco, additional, Enea, Marco, additional, Calvaruso, Vincenza, additional, Camma, Calogero, additional, and Di Marco, Vito, additional

Published
2023
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7. Ruling out varices needing treatment with a non-invasive score in patients with compensated HBV cirrhosis

Author

Maria Rizzo, Giacomo Emanuele, primary, Graceffa, Pietro, additional, Bronte, Fabrizio, additional, Falco, Giuseppe, additional, Rancatore, Gabriele, additional, Celsa, Ciro, additional, Reina, Giada, additional, Simone, Fabio, additional, Peralta, Sergio, additional, Craxi, Antonio, additional, Di Marco, Vito, additional, and Calvaruso, Vincenza, additional

Published
2022
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10. EFFECTIVENESS OF 1-L POLYETHYLENE GLYCOL PLUS ASCORBATE VERSUS 4-L POLYETHYLENE GLYCOL FOR COLONOSCOPY CLEANSING IN SPLIT-DOSE: A MULTICENTRE, RANDOMIZED, CLINICAL TRIAL (OVER2019)

Author

Vassallo, Roberto, Maida, Marcello, Zullo, Angelo, Venezia, Ludovica, Montalbano, Luigi maria, Di Mitri, Roberto, Peralta, Marco, Virgilio, Clara, Pallio, Socrate, Pluchino, Dario, D'Amore, Fabio, Santagati, Alessio, Sinagra, Emanuele, Graceffa, Pietro, Nicosia, Giuseppe, Camilleri, Salvatore, Gibiliaro, Gerlando, Hadi, Yasmin Abdel, Gabriele, Rancatore, Scalisi, Giuseppe, Melita, Giuseppinella, Magnano, Antonio, and Conoscenti, Giuseppe

Published
2023
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