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3. What is the angular accuracy of regional voxel-based registration for segmental Le Fort I and genioplasty osteotomies?

Author

Han, M.D., Graca, S., and Miloro, M.

Subjects
CONE beam computed tomography, VOXEL-based morphometry, ORTHOGNATHIC surgery, INDEPENDENT variables
Abstract

Among the accuracy analysis techniques for orthognathic surgery, regional voxel-based registration (R-VBR) has robust data, but remains unvalidated for smaller jaw segments. The purpose of this study was to validate the angular accuracy of R-VBR for segmental Le Fort I (SLFI) and genioplasty osteotomies. Postoperative cone beam computed tomography (CBCT) of consecutive patients with three-piece SLFI or genioplasties was rotated to a known pitch/roll/yaw (P/R/Y). Using R-VBR, a copy of the raw CBCT was superimposed onto the rotated CBCT at four mutual regions of interest (ROI): anterior, right posterior, and left posterior maxilla, and chin. The P/R/Y of each was subtracted from those of the rotated CBCT to calculate the angular error. The predictor and outcome variables were ROI and absolute angular error, respectively. The accuracy threshold was 0.5°. Ten SLFI and 34 genioplasties were analyzed based on the sample size calculation. The one-sample t -test and Wilcoxon signed rank test were applied in the analysis. The mean absolute error was 0.20–0.54° for the maxillary segments (all P ≤ 0.01) and 0.83–2.51° for the genioplasty segments (all P < 0.001). R-VBR has variable angular accuracy for SLFI osteotomies and may be insufficient for genioplasty. The findings may allow the design and interpretation of studies on SLFI and genioplasty with greater rigor, thereby contributing to minimizing the discrepancy between planned and achieved outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Do the Images of Neuronal Pathways in the Human Central Nervous System Show Feed-back? A Comparative Study in Fifteen Countries.

Author

Clement, Pierre, Mouelhi, Lassaad, Kochkar, Momah, Valanides, Nicos, Nisiforou, Olia, Thiaw, Seyni Mame, Ndiaye, Valdiodio, Jeanbart, Paula, Horvath, Daniel, Ferreira, Claudia, and Carvalho, Graca S.

Abstract

In the human brain, the neuronal pathways are networks which support our learning, memory and thought, and which work with permanent feedback. However, only 19% of illustrations of these neuronal pathways, in the 55 analysed school textbooks coming from 15 countries, were showing feedbacks. The neuronal pathways related to movements were generally introduced by linear spinal cord reflexes, and sometimes mostly reduced to reflexes. In consequence, in most countries, the scientific knowledge taught with these images of neuronal pathways was linked with an implicit ideology: A clear behaviourism associated with reductionism, and even sometimes with innatism or spiritualism. Two thirds of the few images with feedback were related to vegetative functions: the neuro-hormonal control of female and male reproduction, and of heart and breathing rhythms. Nevertheless, even for these vegetative controls, there was not any feedback in several of the 55 analysed textbooks. Only in three countries, the double innervation (gamma and alpha) of striated muscles, with the regulatory function of the neuro-muscular spindle, was illustrated with only one image in each of the three corresponding textbooks. Few images illustrated neuronal pathways in the brain, and only exceptionally as the neuronal networks (with feedback) which are the supports of our memory and of our thought. The persistence of the same kind of images in school textbooks of these contrasted countries suggest that the conceptions of human brain are less linked to national socio-cultural contexts rather than to international dominant ideologies. (Contains 1 footnote, 2 tables, and 12 figures.)

Published
2010

5. Comparing Health Education Approaches in Textbooks of Sixteen Countries

Author

Carvalho, Graca S., Dantas, Catarina, Rauma, Anna-Liisa, Luzi, Daniela, Ruggieri, Roberta, Bogner, Franz, Geier, Christine, Caussidier, Claude, Berger, Dominique, and Clement, Pierre

Abstract

Classically, health education has provided mainly factual knowledge about diseases and their prevention. This educational approach is within the so called Biomedical Model (BM). It is based on pathologic (Pa), curative (Cu) and preventive (Pr) conceptions of health. In contrast, the Health Promotion (HP) approach of health education intends to improve health by promoting healthy habits (He) and by developing empowerment (Ep) for a healthy decision-making with regard to environmental (Ev) challenges. The aim of the present study focused on a comparison of the emphasis on either model (BM or HP) as it is presented by textbooks from 16 countries. Each country team analysed the textbooks that are more frequently used at each educational level. Text and image analysis identified that some countries, such as France and Italy, as more associated with the Biomedical Model, whereas Germany, Mozambique and Finland were more linked to the Health Promotion approach. Data organised for four pupils' age groups (6-9, 10-12, 13-15, 16-18 years old) showed that text and images of the same textbooks gave similar results in terms of following either the BM or HP model, and showed different indicators of consistency (Pa, Cu, Pr for BM; and He, Ep, Ev for HP). Furthermore, although the analyses might be, to a certain extent, subjective (depending on the researcher), it was shown to be very reliable, since all countries, whose textbooks were analysed for the 4 age groups or only the 3 age groups, showed a similar tendency of evolving from a HP (early ages) to a BM approach (elder ages). The interesting finding that the younger pupils' textbooks were more associated with the Health Promotion pole, whereas the older pupils' textbooks were consistent with the Biomedical Model pole seems to be a matter of further and deep investigation. (Contains 1 table and 7 figures.)

Published
2008

11. Trends in Environmental Education Images of Textbooks from Western and Eastern European Countries and Non-European Countries

Author

Carvalho, Graca S., Tracana, Rosa Branca, Skujiene, Grita, and Turcinaviciene, Jurga

Abstract

Textbook analysis is seen as a major element for studying environmental education addressing pupils, image analysis being rather relevant when studying textbooks written in 11 languages. We analysed 25 textbooks from 14 countries addressed to 14-16-year-old pupils, focusing on: (1) local and foreign/global images; (2) urban/rural and nature images; (3) negative impact, human management, and the beauty of nature; and (4) men and women in images with negative and positive impact. We distinguished some trends between Western (WEc) and Eastern (EEc) European countries and non-European countries (NEc). In contrast to textbooks from EEc and NEc, which tend to show the beauty of nature with little human influence, WEc textbooks tend to exhibit more images of urban/rural landscape, of human negative impact and of human management, expressing an anthropocentric view of the environment. Men are usually more present in textbook images than women. However, some images exhibiting more women than men could be found in textbooks from WEc and EEc, but never in NEc. In negative impact pictures, men are more often present than women but NEc women are never present in such images. Women are more frequent than men in positive impact images. Results suggest that textbooks from EEc and NEc should give more emphasis to human management and urban/rural images, whereas those from WEc should give more attention to the beauty of nature. A balance in the presence of men and women in images should be a matter of greater concern by all textbooks' authors and publishers. (Contains 5 figures and 3 tables.)

Published
2011
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12. Health Knowledge Construction and Pedagogical Style in Finnish Health Education Textbooks

Author

Kosonen, Anna-Liisa, Haapala, Irja, Kuurala, Sade, Mielonen, Salla, Hanninen, Osmo, and Carvalho, Graca S.

Abstract

Purpose: The purpose of this paper is to compare the construction of health knowledge in the Finnish national curriculum and recent Finnish health education textbooks, at primary and secondary levels of education. The authors examine the visual and textual content of the textbooks in an attempt to identify their pedagogical style and approach to health education. Design/methodology/approach: The study is part of an international, European Union funded, FP6 STREP Project, Biohead-Citizen. Conceptual health knowledge construction is analysed evaluating the emphasis placed on a biomedical model or on a health promotion (?HP) approach. Pedagogical style of the text and illustration is classified as either neutral, persuasive, participative or injunctive, out of which especially persuasive and participative reflect the constructionist approach. Findings: The textbooks cover a wide range of health topics and meet the core contents of the national curriculum. The approach used was primarily that of HP and used a persuasive and participative approach. The pedagogical style of text, tasks and illustrations reflected current pedagogical thinking. Research limitations/implications: The study encourages future research to explore the effects of pedagogical construction on materials and learning in health education. Originality/value: The paper usefully analyzes the pedagogical properties of recent Finnish health knowledge textbooks. (Contains 8 tables.)

Published
2009
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13. Addictive Substances: Textbook Approaches from 16 Countries

Author

Carvalho, Graca S., Jourdan, Didier, and Goncalves, Artur

Abstract

Schools have been identified as one of the appropriate settings for addiction prevention since this is the place where pupils may come into contact with drugs for the first time and experiment with them, with the possibility of becoming addicted. To be effective, school-based drug education must be firmly based on knowledge of oneself and knowledge of the effects of various addictive substances. Biology education is then an essential part of school-based drug education. The aim of this work was to compare the approach taken towards addictive substances in textbooks within 16 countries involved in the European project BIOHEAD-CITIZEN. We used a specific part of the project grid for substance abuse (alcohol, tobacco and other drugs) and focussed on three major indicators: physical effects, psychological effects and social effects. Generally, in all 16 countries, the educative approaches taken in their textbooks include the three dimensions. Textbooks mainly employ text rather than visual images, and some countries' textbooks have only text. Moroccan and Mozambican textbooks do not mention tobacco and other drugs, respectively. The comparative analyses highlighted that the Finnish textbook is the most comprehensive; the only one, in the study, to have a specific Health Education teaching module. (Contains 3 figures.)

Published
2009
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14. Analysing the Theme of Pollution in Portuguese Geography and Biology Textbooks

Author

Tracana, Rosa Branca, Ferreira, Claudia, Ferreira, Maria Eduarda, and Carvalho, Graca S.

Abstract

Environmental education has been seen as a basic tool to contribute to the change of conceptions, values and attitudes. Textbook analysis is a major element in the evaluation of how the educational goals (at the legislative level of national programmes) are implemented at the school level. The aim of the present study was to analyse the progression of the topic Pollution along the 12 years of Portuguese primary and secondary schools, since the first year (5/6 years old) up to the 12th school year (16/17 years old), giving special attention to the "Impact on humankind", "Economic consequences", "Social risks", "Aesthetic values" and "Ethical, moral and cultural motivations". Results showed that: (1) the planet is seen as a resource for humankind instead of a resource shared with other living beings; (2) it is given a stronger reliance on technologies in sustainable development rather than to changes of individual and social behaviour; and (3) it is conferred unlimited trust in science and technology solutions instead of using the principle of precaution. This study shows that a change of textbooks is recommended in order to give more emphasis to the human role in solving the pollution problems and contributing to improve pupils' citizenship. (Contains 5 tables and 3 figures.)

Published
2008
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15. Historical Analysis of Portuguese Primary School Textbooks (1920-2005) on the Topic of Digestion

Author

Carvalho, Graca S., Silva, Rui, and Clement, Pierre

Abstract

Our previous studies have shown that Portuguese primary school pupils and teachers have three main difficulties in the representation of the digestion process: the sequence of the digestive tract, blood absorption, and the relationship of the digestive function with other human functions. In this study we analysed the topic of digestion in 63 Portuguese textbooks (1920-2005). In general, the textual explanation of the digestive process (including reference to blood absorption) is clear, but "confusion" in images is persistent throughout the period studied. To demonstrate the influence of the period of the Portuguese dictatorship (1926-1974), a brief comparison with French textbooks (which developed during the same period with the aim of presenting clearer representations of the digestive tract) was carried out. Results suggest that inadequate images in textbooks may be the main didactic obstacle to accurate learning of the digestive function. (Contains 7 tables and 5 figures.)

Published
2007
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17. An International Study of Young Peoples' Drawings of What Is Inside Themselves.

Author

Reiss, Michael J., Tunnicliffe, Sue Dale, Andersen, Annemarie Moller, Bartoszeck, Amauri, Carvalho, Graca S., Chen, Shao-Yen, Jarman, Ruth, Jonsson, Stefan, Manokore, Viola, Marchenko, Natalya, Mulemwa, Jane, Novikova, Tatyana, Otuka, Jim, Teppa, Sonia, and Van Rooy, Wilhelmina

Abstract

Investigates young peoples' knowledge and the culture influence using a cross-sectional approach. Involves n=586 pupils from 11 different countries and analyzes resultant drawings using a seven point scale where the criterion was anatomical accuracy. (Contains 24 references.) (Author/YDS)

Published
2002

22. Fostering Scientific Citizenship in an Uncertain World : Selected Papers From the ESERA 2021 Conference

Author

Graça S. Carvalho, Ana Sofia Afonso, Zélia Anastácio, Graça S. Carvalho, Ana Sofia Afonso, and Zélia Anastácio

Subjects
Science--Study and teaching--Research--Congresses
Abstract

This edited volume brings together innovative research in the field of Science Education, fostering scientific citizenship in an uncertain world. The nineteen chapters presented in this book address diverse topics, and research approaches carried out in various contexts and settings worldwide, contributing to improving and updating knowledge on science education. The book consists of selected high-quality studies presented at the 14th European Science Education Research Association (ESERA) Conference, held online (due to the Covid-19 pandemic) by the University of Minho, Portugal, between August 30th and September 3rd, 2021. Being of great relevance in contemporary science education, this book stimulates reflection on different approaches to enhance a deeper understanding of how better prepare the coming generations, which is of great interest to science education researchers and science teachers.

Published
2023

25. Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

Author

McGranahan, N., Rosenthal, R., Hiley, C.T., Rowan, A.J., Watkins, T.B.K., Wilson, G.A., Birkbak, N.J., Veeriah, S., Van Loo, P., Herrero, J., Swanton, C., Jamal-Hanjani, M., Shafi, S., Czyzewska-Khan, J., Johnson, D., Laycock, J., Bosshard-Carter, L., Gorman, P., Hynds, R.E., Wilson, G., Horswell, S., Mitter, R., Escudero, M., Stewart, A., Rowan, A., Xu, H., Turajlic, S., Hiley, C., Abbosh, C., Goldman, J., Stone, R.K., Denner, T., Matthews, N., Elgar, G., Ward, S., Costa, M., Begum, S., Phillimore, B., Chambers, T., Nye, E., Graca, S., Al Bakir, M., Joshi, K., Furness, A., Ben Aissa, A., Wong, Y.N.S., Georgiou, A., Quezada, S., Hartley, J.A., Lowe, H.L., Lawrence, D., Hayward, M., Panagiotopoulos, N., Kolvekar, S., Falzon, M., Borg, E., Marafioti, T., Simeon, C., Hector, G., Smith, A., Aranda, M., Novelli, M., Oukrif, D., Janes, S.M., Thakrar, R., Forster, M., Ahmad, T., Lee, S.M., Papadatos-Pastos, D., Carnell, D., Mendes, R., George, J., Navani, N., Ahmed, A., Taylor, M., Choudhary, J., Summers, Y., Califano, R., Taylor, P., Shah, R., Krysiak, P., Rammohan, K., Fontaine, E., Booton, R., Evison, M., Crosbie, P., Moss, S., and the TRACERx Consortium, .

Abstract

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the polymorphic nature of the locus has precluded accurate HLA copy-number analysis. Here, we present loss of heterozygosity in human leukocyte antigen (LOHHLA), a computational tool to determine HLA allele-specific copy number from sequencing data. Using LOHHLA, we find that HLA LOH occurs in 40% of non-small-cell lung cancers (NSCLCs) and is associated with a high subclonal neoantigen burden, APOBEC-mediated mutagenesis, upregulation of cytolytic activity, and PD-L1 positivity. The focal nature of HLA LOH alterations, their subclonal frequencies, enrichment in metastatic sites, and occurrence as parallel events suggests that HLA LOH is an immune escape mechanism that is subject to strong microenvironmental selection pressures later in tumor evolution. Characterizing HLA LOH with LOHHLA refines neoantigen prediction and may have implications for our understanding of resistance mechanisms and immunotherapeutic approaches targeting neoantigens. Video Abstract [Figure presented] Development of the bioinformatics tool LOHHLA allows precise measurement of allele-specific HLA copy number, improves the accuracy in neoantigen prediction, and uncovers insights into how immune escape contributes to tumor evolution in non-small-cell lung cancer.

Published
2017

26. Phylogenetic ctDNA analysis depicts early stage lung cancer evolution

Author

Abbosh, C, Birkbak, NJ, Wilson, GA, Jamal-Hanjani, M, Constantin, T, Salari, R, Quesne, JL, Moore, DA, Veeriah, S, Rosenthal, R, Marafioti, T, Kirkizlar, E, Watkins, TBK, McGranahan, N, Ward, S, Martinson, L, Riley, J, Fraioli, F, Bakir, MA, GrÖnroos, E, Zambrana, F, Endozo, R, Bi, WL, Fennessy, FM, Sponer, N, Johnson, D, Laycock, J, Shafi, S, Czyzewska-Khan, J, Rowan, A, Chambers, T, Matthews, N, Turajlic, S, Hiley, C, Lee, SM, Forster, MD, Ahmad, T, Falzon, M, Borg, E, Lawrence, D, Hayward, M, Kolvekar, S, Panagiotopoulos, N, Janes, SM, Thakrar, R, Ahmed, A, Blackhall, F, Summers, Y, Hafez, D, Naik, A, Ganguly, A, Kareht, S, Shah, R, Joseph, L, Quinn, AM, Crosbie, P, Naidu, B, Middleton, G, Langman, G, Trotter, S, Nicolson, M, Remmen, H, Kerr, K, Chetty, M, Gomersall, L, Fennell, DA, Nakas, A, Rathinam, S, Anand, G, Khan, S, Russell, P, Ezhil, V, Ismail, B, Irvin-sellers, M, Prakash, V, Lester, JF, Kornaszewska, M, Attanoos, R, Adams, H, Davies, H, Oukrif, D, Akarca, AU, Hartley, JA, Lowe, HL, Lock, S, Iles, N, Bell, H, Ngai, Y, Elgar, G, Szallasi, Z, Schwarz, RF, Herrero, J, Stewart, A, Quezada, SA, Van Loo, P, Dive, C, Lin, CJ, Rabinowitz, M, Aerts, HJWL, Hackshaw, A, Shaw, JA, Zimmermann, BG, Swanton, C, Bosshard-Carter, L, Goh, G, Gorman, P, Murugaesu, N, Hynds, RE, Wilson, G, Horswell, S, Al Bakir, M, Mitter, R, Escudero, M, Xu, H, Goldman, J, Stone, RK, Denner, T, Biggs, J, Costa, M, Begum, S, Phillimore, B, Nye, E, Graca, S, Joshi, K, Furness, A, Aissa, AB, Wong, YNS, Georgiou, A, Quezada, S, Simeon, C, Hector, G, Smith, A, Aranda, M, Novelli, M, Forster, M, Papadatos-Pastos, D, Carnell, D, Mendes, R, George, J, Navani, N, Taylor, M, Choudhary, J, Califano, R, Taylor, P, Krysiak, P, Rammohan, K, Fontaine, E, Booton, R, Evison, M, Moss, S, Idries, F, Bishop, P, Chaturved, A, Marie Quinn, A, Doran, H, leek, A, Harrison, P, Moore, K, Waddington, R, Novasio, J, Rogan, J, Smith, E, Tugwood, J, Brady, G, Rothwell, DG, Chemi, F, Pierce, J, Gulati, S, Bellamy, M, Bancroft, H, Kerr, A, Kadiri, S, Webb, J, Djearaman, M, Fennell, D, Le Quesne, J, Moore, D, Thomas, A, Walter, H, Monteiro, W, Marshall, H, Nelson, L, Bennett, J, Primrose, L, Amadi, A, Palmer, S, Miller, J, Buchan, K, Lester, J, Edwards, A, Morgan, F, Verjee, A, MacKenzie, M, Wilcox, M, Smith, S, Gower, N, Ottensmeier, C, Chee, S, Johnson, B, Alzetani, A, Shaw, E, Lim, E, De Sousa, P, Tavares Barbosa, M, Bowman, A, Jordan, S, Rice, A, Raubenheimer, H, Proli, C, Elena Cufari, M, Ronquillo, JC, Kwayie, A, Bhayani, H, Hamilton, M, Bakar, Y, Mensah, N, Ambrose, L, Devaraj, A, Buderi, S, Finch, J, Azcarate, L, Chavan, H, Green, S, Mashinga, H, Nicholson, AG, Lau, K, Sheaff, M, Schmid, P, Conibear, J, Light, T, Horey, T, Danson, S, Bury, J, Edwards, J, Hill, J, Matthews, S, Kitsanta, Y, Suvarna, K, Fisher, P, Keerio, AD, Shackcloth, M, Gosney, J, Postmus, P, Feeney, S, Asante-Siaw, J, Constatin, T, Zimmermann, B, Dentro, S, Dessimoz, C, Shiu, K-K, Bridgewater, J, Hochauser, D, Beck, S, Parker, P, Walczak, H, Enver, T, Proctor, I, Sinclair, R, Lok, C-W, Mitchison, M, Trevisan, G, Lynch, M, Brandner, S, Gishen, F, Tookman, A, Stone, P, Sterling, C, Larkin, J, Attard, G, Eeles, R, Foster, C, Bova, S, Sottoriva, A, Chowdhury, S, Ashish, C, Spicer, J, Stares, M, Lynch, J, Caldas, C, Brenton, J, Fitzgerald, R, Jimenez-Linan, M, Provenzano, E, Cluroe, A, Stewart, G, Watts, C, Gilbertson, R, McDermott, U, Tavare, S, Maughan, T, Tomlinson, I, Campbell, P, McNeish, I, Biankin, A, Chambers, A, Fraser, S, Oien, K, Krebs, M, Marais, R, Carter, L, Nonaka, D, Dhomen, N, Shaw, J, Baijal, S, Tanchel, B, Collard, M, Cockcroft, P, Taylor, J, Colloby, P, Olisemeke, B, Wilson, R, Harrison, D, Loda, M, Flanagan, A, McKenzie, M, Lederman, J, Sharp, A, and Farrelly, L

Subjects
0301 basic medicine, Oncology, Lung Neoplasms, IMPACT, Biopsy, DNA Mutational Analysis, Drug resistance, Metastasis, 0302 clinical medicine, Limit of Detection, Carcinoma, Non-Small-Cell Lung, Medicine, Neoplasm Metastasis, Early Detection of Cancer, Multidisciplinary, medicine.diagnostic_test, Phylogenetic tree, DNA, Neoplasm, STATISTICS, 3. Good health, Tumor Burden, Multidisciplinary Sciences, Cell Tracking, PEACE consortium, 030220 oncology & carcinogenesis, Disease Progression, Science & Technology - Other Topics, medicine.medical_specialty, CARCINOMA, Tumour heterogeneity, General Science & Technology, Early detection, Evolution, Molecular, 03 medical and health sciences, Internal medicine, MD Multidisciplinary, Carcinoma, Humans, Cell Lineage, Lung cancer, Postoperative Care, Science & Technology, MUTATIONS, TRACERx consortium, business.industry, CIRCULATING TUMOR DNA, Reproducibility of Results, medicine.disease, R1, NEGATIVE BREAST-CANCER, Clone Cells, 030104 developmental biology, Drug Resistance, Neoplasm, UPTAKE RATIO, Immunology, FDG PET, Neoplasm Recurrence, Local, business, Multiplex Polymerase Chain Reaction
Abstract

The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA) has not yet been demonstrated. Here we use a tumour-specific phylogenetic approach to profile the ctDNA of the first 100 TRACERx (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy (Rx)) study participants, including one patient who was also recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study. We identify independent predictors of ctDNA release and analyse the tumour-volume detection limit. Through blinded profiling of postoperative plasma, we observe evidence of adjuvant chemotherapy resistance and identify patients who are very likely to experience recurrence of their lung cancer. Finally, we show that phylogenetic ctDNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies.

Published
2017

27. Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

Author

Arce Vargas, F, Furness, AJS, Solomon, I, Joshi, K, Mekkaoui, L, Lesko, MH, Miranda Rota, E, Dahan, R, Georgiou, A, Sledzinska, A, Ben Aissa, A, Franz, D, Werner Sunderland, M, Wong, YNS, Henry, JY, O'Brien, T, Nicol, D, Challacombe, B, Beers, SA, Spain, L, Wotherspoon, A, Francis, N, Smith, M, Strauss, D, Hayes, A, Soultati, A, Stares, M, Lynch, J, Fotiadis, N, Fernando, A, Hazell, S, Chandra, A, Pickering, L, Rudman, S, Chowdhury, S, Swanton, C, Jamal-Hanjani, M, Veeriah, S, Shafi, S, Czyzewska-Khan, J, Johnson, D, Laycock, J, Bosshard-Carter, L, Goh, G, Rosenthal, R, Gorman, P, Murugaesu, N, Hynds, RE, Wilson, G, Birkbak, NJ, Watkins, TBK, McGranahan, N, Horswell, S, Mitter, R, Escudero, M, Stewart, A, Van Loo, P, Rowan, A, Xu, H, Turajlic, S, Hiley, C, Abbosh, C, Goldman, J, Stone, RK, Denner, T, Matthews, N, Elgar, G, Ward, S, Biggs, J, Costa, M, Begum, S, Phillimore, B, Chambers, T, Nye, E, Graca, S, Al Bakir, M, Hartley, JA, Lowe, HL, Herrero, J, Lawrence, D, Hayward, M, Panagiotopoulos, N, Kolvekar, S, Falzon, M, and Borg, E

Subjects
hemic and immune systems, chemical and pharmacologic phenomena
Abstract

CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited activity against established tumors. We demonstrated that CD25 expression is largely restricted to tumor-infiltrating Treg cells in mice and humans. While existing anti-CD25 antibodies were observed to deplete Treg cells in the periphery, upregulation of the inhibitory Fc gamma receptor (FcγR) IIb at the tumor site prevented intra-tumoral Treg cell depletion, which may underlie the lack of anti-tumor activity previously observed in pre-clinical models. Use of an anti-CD25 antibody with enhanced binding to activating FcγRs led to effective depletion of tumor-infiltrating Treg cells, increased effector to Treg cell ratios, and improved control of established tumors. Combination with anti-programmed cell death protein-1 antibodies promoted complete tumor rejection, demonstrating the relevance of CD25 as a therapeutic target and promising substrate for future combination approaches in immune-oncology.

Published
2017

28. Teachers' supporting students with parents having mental health problems. A scoping review

Author

Bruland, Dirk, Pinheiro, Paulo, Bröder, Janine, Okan, Orkan, Carvalho, Graca S, Saboga-Nunes, Luis, Bond, Emma, Wahl, Patricia, Fretian, Alexandra, Bauer, Ullrich, and Universidade do Minho

Subjects
Mental health promotion, Ciências da Educação [Ciências Sociais], Family health, education, Ciências Sociais::Ciências da Educação, Mental health literacy
Abstract

Children whose parents have mental health issues respond to associated familial stressors with symptomatic behaviors and are, themselves, at considerably higher risk of developing serious mental health problems. Teachers are the most likely professionals who are able to recognize behavior changes and mental health needs of children. This article aims to provide an overview of the current state-of-the-art research on teachers’ mental health literacy including how teachers identify and support these children. A scoping review was undertaken with six databases by using English and German search terms for articles published between January 1990 and July 2017. This review identifies a research gap in mental health (literacy) research for a major cause of mental health issues in children. There is little recognition of students’ familial environment in the research undertaken. The founded studies show that identifying affected children is difficult for teachers. If teachers identify those children, they have great uncertainties to work with this situation. Identified teachers’ responses are insufficient for children and mostly depends on individual attitudes and experience with mental health issues. Teachers are highly stressed by the child’s school situation and need support themselves to support children adequately. Better support for teachers is required in order to prepare them adequately to support children. Based on the results opportunities for teachers’ mental health literacy are discussed to expand teachers’ ability to promote mental health in children with parents having mental health issues as well as future research activities. Keywords: mental health promotion, school teachers, student, mental health literacy, family health., CIEC – Research Centre on Child Studies, IE, UMinho (FCT R&D unit 317), Portugal, National Funds through the FCT (Foundation for Science and Technology) and co-financed by European Regional Development Funds (FEDER) through the Competitiveness and Internationalization Operational Program (POCI) through CIEC (Research Centre on Child Studies, of the University of Minho) with the reference POCI-01-0145-FEDER-007562, info:eu-repo/semantics/publishedVersion

Published
2017

29. Recent ASDEX Upgrade research in support of ITER and DEMO

Author

Zohm, H, Ahn, J, Aho Mantila, L, Äkäslompolo, S, Angioni, C, Asunta, O, de Baar, M, Balden, M, Barrera Orte, L, Behler, K, Belapure, J, Bergmann, A, Bernardo, J, Bernert, M, Beurskens, M, Biancalani, A, Bilato, R, Birkenmeier, G, Bobkov, V, Bock, A, Bogomolov, A, Bolzonella, T, Boom, J, Böswirth, B, Bottereau, C, Bottino, A, van den Brand, H, Braun, F, Brezinsek, S, Brochard, F, Buhler, A, Burckhart, A, Camenen, Y, Carvalho, P, Carrasco, G, Cazzaniga, C, Carralero, D, Casali, L, Cavedon, M, Challis, C, Chankin, A, Chapman, I, Clairet, F, Classen, I, Coda, S, Coelho, R, Coenen, J, Colas, L, Conway, G, Costea, S, Coster, D, CROCI, GABRIELE, Cseh, G, Czarnecka, A, Day, C, de Marné, P, Denner, P, D'Inca, R, Douai, D, Drube, R, Dunne, M, Duval, B, Dux, R, Eich, T, Elgeti, S, Engelhardt, K, Ertl, K, Esposito, B, Fable, E, Fantz, U, Faugel, H, Felici, F, Fietz, S, Figueredo, A, Fischer, R, Ford, O, Franzen, P, Frassinetti, L, Fröschle, M, Fuchert, G, Fünfgelder, H, Fuchs, J, Gál, K, Garavaglia, S, Garcia Muñoz, M, Geiger, B, Giannone, L, Giovannozzi, E, Gleason González, C, Görler, T, Goodman, T, GORINI, GIUSEPPE, da Graca, S, Gräter, A, Granucci, G, Greuner, H, Grießhammer, J, Groth, M, Gude, A, Günter, S, Guimarais, L, Haas, G, Hakola, A, Happel, T, Harrison, J, Hatch, D, Hauer, V, Hauff, T, Heinemann, B, Heinzel, S, Hellsten, T, Hennequin, P, Herrmann, A, Heyn, E, Hobirk, J, Hölzl, M, Höschen, T, Holm, J, Hopf, C, Hoppe, F, Horvath, L, Houben, A, Huber, A, Igochine, V, Ilkei, T, Jacob, W, Jacobsen, A, Jacquot, J, Janzer, M, Jaulmes, F, Jenko, F, Jensen, T, Joffrin, E, Käsemann, C, Kallenbach, A, Kálvin, S, Kantor, M, Kappatou, A, Kardaun, O, Karhunen, J, Kim, D, Kimmig, S, Kirk, A, J, Klingshirn, H, Kocan, M, Koch, F, Kocsis, G, Köhn, A, Köppen, M, Kötterl, J, Koslowski, R, Koubiti, M, Kraus, M, Krieger, K, Krivska, A, Kogut, D, Krämer Flecken, A, Kurki Suonio, T, Kurzan, B, Lackner, K, Laggner, F, Lang, P, Lauber, P, Lazányi, N, Lazaros, A, Lebschy, A, Leuterer, F, Liang, Y, Linsmeier, h, Lipschultz, B, Litnovski, A, Lohs, A, Luhmann, N, Lunt, T, Lyssoivan, A, Madsen, J, Maier, H, Maj, O, Mailloux, J, Maljaars, E, Mancini, A, Manhard, A, Mank, K, E, Manso, M, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Markina, E, Martens, C, Martin, P, Mayer, A, Mayer, M, Mazon, D, McCarthy, P, McDermott, R, Meisl, G, Meister, H, Medvedeva, A, Merkel, P, Merkel, R, Mertens, V, Meyer, H, Meyer, O, Milanesio, D, Miettunen, J, Mlynek, A, Monaco, F, Moro, A, Moseev, D, Müller, H, Müller, S, Münich, M, Nabais, F, Nemes Czopf, A, Neu, G, Neu, R, Nielsen, A, Nikolaeva, V, Nielsen, S, NOCENTE, MASSIMO, Nold, B, M, Noterdaeme, J, Nowak, S, Oberkofler, M, Ochoukov, R, Odstrcil, T, Papp, G, Park, H, Pau, A, Pautasso, G, Penzel, F, Petersson, P, Piovesan, P, Piron, C, Plaum, B, Plöckl, B, Plyusnin, V, Podoba, Y, Pokol, G, Pompon, F, Poli, E, Polozhiy, K, Porte, L, Potzel, S, Preuss, R, Prisiazhniuk, D, Pütterich, T, Ramish, M, Rapson, C, Rasmussen, J, Rathgeber, S, Raupp, G, Réfy, D, Reich, M, Reimold, F, Reinke, M, Ribeiro, T, Riedl, R, Rittich, D, Rocchi, G, Rodriguez Ramos, M, Rohde, V, Roth, J, Rott, M, Rubel, M, Ryter, F, Saarelma, S, Salewski, M, Salmi, A, Sanchis Sanchez, L, Santos, G, Santos, J, Sauter, O, Scarabosio, A, Schall, G, Schmid, K, Schmitz, O, Schneider, P, Schneider, W, Schneller, M, Schrittwieser, R, Schubert, M, Schwarz Selinger, T, Schweinzer, J, Scott, B, Sehmer, T, Sertoli, M, Shalpegin, A, Sias, G, Siccinio, M, Sieglin, B, Sigalov, A, Silva, A, Silva, C, Simon, P, Simpson, J, Snicker, A, Sommer, F, Sozzi, C, Spolaore, M, Stejner, M, Stober, J, Stobbe, F, Stroth, U, Strumberger, E, Sugiyama, K, J, Sun, Suttrop, W, Szepesi, T, Tál, B, Tala, T, Tardini, G, Tichmann, C, Told, D, Tophøj, L, Tudisco, O, von Toussaint, U, Trevisan, G, Treutterer, W, Tripský, M, Valisa, M, Valovic, M, Varela, P, Varoutis, S, Vezinet, D, Vianello, N, Vicente, J, Vierle, T, Viezzer, E, Vorpahl, C, Wagner, D, Wang, X, Wauters, T, Weidl, I, Weiland, M, Weller, A, Wenninger, R, Wieland, B, Wiesinger, M, Willensdorfer, M, Wiringer, B, Wischmeier, M, Wolf, R, Wolfrum, E, Wünderlich, D, Würsching, E, Yang, Z, Yu, Q, Zammuto, I, Zarzoso, D, Zasche, D, van Zeeland, M, Zehetbauer, T, Zilker, M., Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, European Commission (EC), Science and Technology of Nuclear Fusion, Zohm, H, Ahn, J, Aho Mantila, L, Äkäslompolo, S, Angioni, C, Asunta, O, de Baar, M, Balden, M, Barrera Orte, L, Behler, K, Belapure, J, Bergmann, A, Bernardo, J, Bernert, M, Beurskens, M, Biancalani, A, Bilato, R, Birkenmeier, G, Bobkov, V, Bock, A, Bogomolov, A, Bolzonella, T, Boom, J, Böswirth, B, Bottereau, C, Bottino, A, van den Brand, H, Braun, F, Brezinsek, S, Brochard, F, Buhler, A, Burckhart, A, Camenen, Y, Carvalho, P, Carrasco, G, Cazzaniga, C, Carralero, D, Casali, L, Cavedon, M, Challis, C, Chankin, A, Chapman, I, Clairet, F, Classen, I, Coda, S, Coelho, R, Coenen, J, Colas, L, Conway, G, Costea, S, Coster, D, Croci, G, Cseh, G, Czarnecka, A, Day, C, de Marné, P, Denner, P, D'Inca, R, Douai, D, Drube, R, Dunne, M, Duval, B, Dux, R, Eich, T, Elgeti, S, Engelhardt, K, Ertl, K, Esposito, B, Fable, E, Fantz, U, Faugel, H, Felici, F, Fietz, S, Figueredo, A, Fischer, R, Ford, O, Franzen, P, Frassinetti, L, Fröschle, M, Fuchert, G, Fünfgelder, H, Fuchs, J, Gál, K, Garavaglia, S, Garcia Muñoz, M, Geiger, B, Giannone, L, Giovannozzi, E, Gleason González, C, Görler, T, Goodman, T, Gorini, G, da Graca, S, Gräter, A, Granucci, G, Greuner, H, Grießhammer, J, Groth, M, Gude, A, Günter, S, Guimarais, L, Haas, G, Hakola, A, Happel, T, Harrison, J, Hatch, D, Hauer, V, Hauff, T, Heinemann, B, Heinzel, S, Hellsten, T, Hennequin, P, Herrmann, A, Heyn, E, Hobirk, J, Hölzl, M, Höschen, T, Holm, J, Hopf, C, Hoppe, F, Horvath, L, Houben, A, Huber, A, Igochine, V, Ilkei, T, Jacob, W, Jacobsen, A, Jacquot, J, Janzer, M, Jaulmes, F, Jenko, F, Jensen, T, Joffrin, E, Käsemann, C, Kallenbach, A, Kálvin, S, Kantor, M, Kappatou, A, Kardaun, O, Karhunen, J, Kim, D, Kimmig, S, Kirk, A, J, K, H, Kocan, M, Koch, F, Kocsis, G, Köhn, A, Köppen, M, Kötterl, J, Koslowski, R, Koubiti, M, Kraus, M, Krieger, K, Krivska, A, Kogut, D, Krämer Flecken, A, Kurki Suonio, T, Kurzan, B, Lackner, K, Laggner, F, Lang, P, Lauber, P, Lazányi, N, Lazaros, A, Lebschy, A, Leuterer, F, Liang, Y, Linsmeier, H, Lipschultz, B, Litnovski, A, Lohs, A, Luhmann, N, Lunt, T, Lyssoivan, A, Madsen, J, Maier, H, Maj, O, Mailloux, J, Maljaars, E, Mancini, A, Manhard, A, Mank, K, E, M, M, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Markina, E, Martens, C, Martin, P, Mayer, A, Mayer, M, Mazon, D, Mccarthy, P, Mcdermott, R, Meisl, G, Meister, H, Medvedeva, A, Merkel, P, Merkel, R, Mertens, V, Meyer, H, Meyer, O, Milanesio, D, Miettunen, J, Mlynek, A, Monaco, F, Moro, A, Moseev, D, Müller, H, Müller, S, Münich, M, Nabais, F, Nemes Czopf, A, Neu, G, Neu, R, Nielsen, A, Nikolaeva, V, Nielsen, S, Nocente, M, Nold, B, M, N, J, Nowak, S, Oberkofler, M, Ochoukov, R, Odstrcil, T, Papp, G, Park, H, Pau, A, Pautasso, G, Penzel, F, Petersson, P, Piovesan, P, Piron, C, Plaum, B, Plöckl, B, Plyusnin, V, Podoba, Y, Pokol, G, Pompon, F, Poli, E, Polozhiy, K, Porte, L, Potzel, S, Preuss, R, Prisiazhniuk, D, Pütterich, T, Ramish, M, Rapson, C, Rasmussen, J, Rathgeber, S, Raupp, G, Réfy, D, Reich, M, Reimold, F, Reinke, M, Ribeiro, T, Riedl, R, Rittich, D, Rocchi, G, Rodriguez Ramos, M, Rohde, V, Roth, J, Rott, M, Rubel, M, Ryter, F, Saarelma, S, Salewski, M, Salmi, A, Sanchis Sanchez, L, Santos, G, Santos, J, Sauter, O, Scarabosio, A, Schall, G, Schmid, K, Schmitz, O, Schneider, P, Schneider, W, Schneller, M, Schrittwieser, R, Schubert, M, Schwarz Selinger, T, Schweinzer, J, Scott, B, Sehmer, T, Sertoli, M, Shalpegin, A, Sias, G, Siccinio, M, Sieglin, B, Sigalov, A, Silva, A, Silva, C, Simon, P, Simpson, J, Snicker, A, Sommer, F, Sozzi, C, Spolaore, M, Stejner, M, Stober, J, Stobbe, F, Stroth, U, Strumberger, E, Sugiyama, K, J, S, Suttrop, W, Szepesi, T, Tál, B, Tala, T, Tardini, G, Tichmann, C, Told, D, Tophøj, L, Tudisco, O, von Toussaint, U, Trevisan, G, Treutterer, W, Tripský, M, Valisa, M, Valovic, M, Varela, P, Varoutis, S, Vezinet, D, Vianello, N, Vicente, J, Vierle, T, Viezzer, E, Vorpahl, C, Wagner, D, Wang, X, Wauters, T, Weidl, I, Weiland, M, Weller, A, Wenninger, R, Wieland, B, Wiesinger, M, Willensdorfer, M, Wiringer, B, Wischmeier, M, Wolf, R, Wolfrum, E, Wünderlich, D, Würsching, E, Yang, Z, Yu, Q, Zammuto, I, Zarzoso, D, Zasche, D, van Zeeland, M, Zehetbauer, T, Zilker, M, Max-Planck-Institut für Plasmaphysik [Garching] (IPP), Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), ASDEX Upgrade Team, Max Planck Institute for Plasma Physics, Max Planck Society, and EUROfusion MST1 Team

Subjects
Nuclear and High Energy Physics, Tokamak, Cyclotron, Condensed Matter Physic, Collisionality, 01 natural sciences, Resonant magnetic perturbations, Electron cyclotron resonance, 010305 fluids & plasmas, law.invention, Nuclear physics, ASDEX Upgrade, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], law, ITER, 0103 physical sciences, 010306 general physics, Edge-localized mode, tokamak physic, DEMO, nuclear fusion, Physics, Divertor, Condensed Matter Physics, Tokamak physics, Nuclear fusion, tokamak physics
Abstract

Recent experiments on the ASDEX Upgrade tokamak aim at improving the physics base for ITER and DEMO to aid the machine design and prepare efficient operation. Type I edge localized mode (ELM) mitigation using resonant magnetic perturbations (RMPs) has been shown at low pedestal collisionality ( ν ∗ ped < 0 . 4 ) . In contrast to the previous high ν ∗ regime, suppression only occurs in a narrow RMP spectral window, indicating a resonant process, and a concomitant confinement drop is observed due to a reduction of pedestal top density and electron temperature. Strong evidence is found for the ion heat flux to be the decisive element for the L–H power threshold. A physics based scaling of the density at which the minimum P LH occurs indicates that ITER could take advantage of it to initiate H-mode at lower density than that of the final Q = 10 operational point. Core density fluctuation measurements resolved in radius and wave number show that an increase of R/L T e introduced by off-axis electron cyclotron resonance heating (ECRH) mainly increases the large scale fluctuations. The radial variation of the fluctuation level is in agreement with simulations using the GENE code. Fast particles are shown to undergo classical slowing down in the absence of large scale magnetohydrodynamic (MHD) events and for low heating power, but show signs of anomalous radial redistribution at large heating power, consistent with a broadened off-axis neutral beam current drive current profile under these conditions. Neoclassical tearing mode (NTM) suppression experiments using electron cyclotron current drive (ECCD) with feedback controlled deposition have allowed to test several control strategies for ITER, including automated control of (3,2) and (2,1) NTMs during a single discharge. Disruption mitigation studies using massive gas injection (MGI) can show an increased fuelling efficiency with high field side injection, but a saturation of the fuelling efficiency is observed at high injected mass as needed for runaway electron suppression. Large locked modes can significantly decrease the fuelling efficiency and increase the asymmetry of radiated power during MGI mitigation. Concerning power exhaust, the partially detached ITER divertor scenario has been demonstrated at P sep /R = 10 MW m − 1 in ASDEX Upgrade, with a peak time averaged target load around 5MWm − 2 , well consistent with the component limits for ITER. Developing this towards DEMO, full detachment was achieved at P sep /R = 7MWm − 1 and stationary discharges with core radiation fraction of the order of DEMO requirements (70% instead of the 30% needed for ITER) were demonstrated. Finally, it remains difficult to establish the standard ITER Q = 10 scenario at low q 95 = 3 in the all-tungsten (all-W) ASDEX Upgrade due to the observed poor confinement at low β N . This is mainly due to a degraded pedestal performance and hence investigations at shifting the operational point to higher β N by lowering the current have been started. At higher q 95 , pedestal performance can be recovered by seeding N 2 as well as CD 4 , which is interpreted as improved pedestal stability due to the decrease of bootstrap current with increasing Z eff . Concerning advanced scenarios, the upgrade of ECRH power has allowed experiments with central ctr-ECCD to modify the q -profile in improved H-mode scenarios, showing an increase in confinement at still good MHD stability with flat elevated q -profiles at values between 1.5 and 2. European Commission (EUROfusion 633053)

Published
2015

31. NBI-driven Alfvenic modes at ASDEX Upgrade

Author

Lauber, Ph., Classen, I. G. J., Curran, D., Igochine, V., Geiger, B., Da Graca, S., Garcia-Munoz, M., Maraschek, M., McCarthy, P., ASDEX Upgrade Team, and ASDEX Upgrade Team

Subjects
Physics, Nuclear and High Energy Physics, Toroid, Tokamak, Phase (waves), Condensed Matter Physics, Ion, law.invention, Shear (sheet metal), ASDEX Upgrade, Position (vector), law, Excited state, Atomic physics
Abstract

A large variety of electromagnetic modes excited by NBI-generated energetic ions are observed in the early phase of many discharges at ASDEX Upgrade. In addition to the well-known reversed shear Alfven eigenmodes (RSAE) and the toroidal Alfven eigenmodes (TAE), a set of modes around 70 kHz is observed as recently described in [7]. The modes were identified to be beta-induced Alfven eigenmodes (BAE) connected with the appearance of the q = 2 and the q = 1.5 surface during the current ramp-up phase. In the view of ITER, these BAEs may occur in scenarios with q approximate to 2 (scenario 4) and therefore add significantly to the transport of energetic ions due to RSAEs and TAEs. Experimentally, the combination of ECE, soft-x-ray and magnetic measurements allows for a very reliable mode position and mode structure determination. The measurements are compared with linear gyrokinetic calculations employing the LIGKA code that uses a fully kinetic model to describe fast-particle-driven modes in general tokamak geometry.

Published
2012

32. I-mode studies at ASDEX Upgrade

Author

Ryter, F., Mcdermott, R. M., Putterich, T., Vicente, J., Viezzer, E., Wolfrum, E., Angioni, C., Bernert, M., Boom, J. C., Fischer, R., Geiger, B., Da Graca, S., Kurzan, B., Luhmann, N. C., Park, H. K., Rathgeber, S. K., Sauter, P., Villensdorfer, M., and ASDEX Upgrade Team

Published
2011

33. Investigation of fast particle driven instabilities by 2D electron cyclotron emission imaging on ASDEX Upgrade

Author

Classen, I. G. J., Lauber, Ph., Curran, D., Boom, J. E., Tobias, B. J., Domier, C. W., Luhmann Jr., N. C., Park, H. K., Garcia Munoz, M., Geiger, B., Maraschek, M., Van Zeeland, M. A., da Graca, S., ASDEX Upgrade Team, Science and Technology of Nuclear Fusion, and ASDEX Upgrade Team

Subjects
Physics, Tokamak, Steady state, Plasma parameters, Cyclotron, Phase (waves), Electron, Condensed Matter Physics, law.invention, Nuclear Energy and Engineering, ASDEX Upgrade, Physics::Plasma Physics, law, Physics::Space Physics, Atomic physics, Beam (structure)
Abstract

Detailed measurements of the 2D mode structure of Alfv´en instabilities in the current ramp-up phase of neutral beam heated discharges were performed on ASDEX Upgrade, using the electron cyclotron emission imaging (ECEI) diagnostic. This paper focuses on the observation of reversed shear Alfv´en eigenmodes (RSAEs) and bursting modes that, with the use of the information from ECEI, have been identified as beta-induced Alfv´en eigenmodes (BAEs). Both RSAEs with first and second radial harmonic mode structures were observed. Calculations with the linear gyro-kinetic code LIGKA revealed that the ratio of the damping rates and the frequency difference between the first and second harmonic modes strongly depended on the shape of the qprofile. The bursting character of the BAE type modes, which were radially localized to rational q surfaces, was observed to sensitively depend on the plasma parameters, ranging from strongly bursting to almost steady state.

Published
2011

34. Low-frequency Alfvén Eigenmodes during the Sawtooth Cycle at ASDEX Upgrade

Author

Curran, D., Lauber, Ph., McCarthy, P. J., da Graca, S., Igochine, V., ASDEX Upgrade Team, and ASDEX Upgrade Team

Subjects
Physics, Tokamak, Plasma, Sawtooth wave, Condensed Matter Physics, Computational physics, law.invention, Nuclear Energy and Engineering, ASDEX Upgrade, Physics::Plasma Physics, Normal mode, law, Dispersion relation, Physics::Space Physics, Electron temperature, Nuclear fusion, Atomic physics
Abstract

The confinement of fast particles, present in tokamak plasmas as nuclear fusion products and through external heating, will be essential for any future reactor. Fast particles can be expelled from the plasma through their interaction with Alfven eigenmode (AE) instabilities. AEs can exist in gaps in the Alfven continuum created by plasma equilibrium non-uniformities. In ASDEX Upgrade low-frequency modes in the Alfven-acoustic frequency regime, including beta-induced Alfven eigenmodes (BAEs) and lower frequency modes with mixed Alfven and acoustic polarizations, have been observed. They exist in gaps in the Alfven continuum opened up by geodesic curvature and finite plasma compressibility. In this paper a kinetic dispersion relation (Lauber et al 2009 Plasma Phys. Control. Fusion 51 124009) is solved numerically to investigate the influence of diamagnetic effects on the evolution of these low-frequency modes during the sawtooth cycle. Other distinct but potentially related modes which sweep significantly upwards in frequency towards the end of the sawtooth cycle are also considered. Using information gained from soft x-ray measurements (Igochine et al 2010 IPP Report 1/338) and electron temperature information from electron cyclotron emission to constrain the safety factor profiles, realistic equilibrium reconstructions for the analysis are obtained using the CLISTE code (Mc Carthy 2012 Plasma Phys. Control. Fusion 54 015010). The results for the mode frequency evolution are then compared with experimental results from ASDEX Upgrade.

Published
2011

35. Axially Symmetric Divertor Experiment (ASDEX) Upgrade Team (vol 81, 033507, 2010)

Author

Adamek, J., Angioni, C., Antar, G., Atanasiu, C.V., Balden, M., Becker, W., Behler, K., Behringer, K., Bergmann, A., Bilato, R., Bobkov, V., Boom, J., Bottino, A., Brambilla, M., Braun, F., Brüdgam, M., Buhler, A., Chankin, A., Classen, I., Conway, G.D., Coster, D.P., de Marne, P., D'Inca, R., Dodt, D., Doerk-Bendig, H., Drube, R., Dux, R., Eich, T., Endstrasser, N., Engelhardt, K., Fahrbach, H.-U., Fattorini, L., Fischer, R., Forest, C., Fuchs, J.C., Gal, K., Munoz, M.G., Adamov, M.G., Giannone, L., Görler, L., Gori, S., da Graca, S., Greuner, H., Gruber, O., Gude, A., Günter, S., Haas, G., Hammer, N., Hauff, T., Heinemann, B., Herrmann, A., Hicks, N., Hobirk, J., Hölzl, M., Holtum, D., Hopf, C., Huart, M., Igochine, V., Janzer, M., Jenko, F., Kagarmanov, A., Kallenbach, A., Kammel, A., Kalvin, S., Kardaun, O., Kaufmann, M., Kick, M., Kirk, A., Klingshirn, H.-J., Koscis, G., Kollotzek, H., Konz, C., Krieger, K., Kurki-Suonio, T., Kurzan, B., Lackner, K., Lang, P.T., Langer, B., Lauber, P., Laux, M., Leuterer, F., Likonen, J., Liu, L., Lohs, A., Lunt, T., Lyssoivan, A., Mank, K., Manso, M.-E., Mantsinen, M., Maraschek, M., Martin, P., Mayer, M., McCarthy, P., McCormick, K., McDermott, R., Meister, H., Meo, Fernando, Merkel, P., Merkel, R., Mertens, V., Merz, F., Meyer, H., Mlynek, A., Monaco, F., Müller, H.-W., Münich, M., Murmann, H., Neu, G., Neu, R., Neuhauser, J., Nold, B., Noterdaeme, J.M., Pautasso, G., Pereverzev, G., Poli, E., Potzel, S., Püschel, M., Pütterich, T., Raupp, G., Reich, M., Reiter, B., Ribeiro, T., Riedl, R., Rohde, V., Roth, J., Rott, M., Ryter, F., Sandmann, W., Santos, J., Sassenberg, K., Sauter, P., Scarabosio, A., Schall, G., Schmid, K., Schneider, P., Schneider, W., Schrittwieser, R., Schweinzer, J., Scott, B., Seidel, U., Sempf, M., Serra, F., Sertoli, M., Siccinio, M., Sigalov, A., Silva, A., Speth, E., Stäbler, A., Stadler, R., Steuer, K.-H., Stober, J., Streibl, B., Strumberger, E., Suttrop, W., Tardini, G., Tichmann, C., Treutterer, W., Urso, L., Vainonen-Ahlgren, E., Varela, P., Vorpahl, C., Wagner, D., Wigger, C., Wischmeier, M., Wolfrum, E., Würsching, E., Yadikin, D., Yu, Q., Zasche, D., Zehetbauer, T., Zilker, M., and Zohm, H.

Subjects
Fusion energy, Fusionsenergi, Fusionsenergiforskning
Published
2010

36. Overview of ASDEX upgrade results

Author

Zohm H., Adamek J., Angioni C., Antar G., Atanasiu C. V., Balden M., Becker W., Behler K., Behringer K., Bergmann A., Bertoncelli T., Bilato R., Bobkov V., Boom J., Bottino A., Brambilla M., Braun F., Bruedgam M., Buhler A., Chankin A., Classen I., Conway G. D., Coster D. P., de Marne P., D'Inca R., Drube R., Dux R., Eich T., Engelhardt K., Esposito B., Fahrbach H-U., Fattorini L., Fink J., Fischer R., Flaws A., Foley M., Forest C., Fuchs J. C., Gal K., Munoz M. Garcia, Adamov M. Gemisic, Giannone L., Goerler T., Gori S., da Graca S., Granucci G., Greuner H., Gruber O., Gude A., Guenter S., Haas G., Hahn D., Harhausen J., Hauff T., Heinemann B., Herrmann A., Hicks N., Hobirk J., Hoelzl M., Holtum D., Hopf C., Horton L., Huart M., Igochine V., Janzer M., Jenko F., Kallenbach A., Kalvin S., Kardaun O., Kaufmann M., Kick M., Kirk A., Klingshirn H-J., Koscis G., Kollotzek H., Konz C., Krieger K., Kurki-Suonio, Kurzan B., Lackner K., Lang P. T., Langer B., Lauber P., Laux M., Leuterer F., Likonen J., Liu L., Lohs A., Lunt T., Lyssoivan A., Maggi C. F., Manini A., Mank K., Manso M-E., Mantsinen M., Maraschek M., Martin P., Mayer M., McCarthy P., McCormick K., Meister H., Meo F., Merkel P., Merkel R., Mertens V., Merz F., Meyer H., Mlynek A., Monaco F., Mueller H-W., Muenich M., Murmann H., Neu G., Neu R., Neuhauser J., Nold B., Noterdaeme J-M., Pautasso G., Pereverzev G., Poli E., Potzel, Pueschel M., Puetterich T., Pugno R., Raupp G., Reich M., Reiter B., Ribeiro T., Riedl R., Rohde V., Roth J., Rott M., Ryter F., Sandmann W., Santos J., Sassenberg, Sauter P., Scarabosio A., Schall G., Schilling H-B., Schirmer J., Schmid A., Schmid K., Schneider W., Schramm G., Schrittwieser R., Schustereder W., Schweinzer J., Schweizer S., Scott B., Seidel U., Sempf M., Serra F., Sertoli M., Siccinio M., Sigalov A., Silva A., Sips C. C., Speth E., Staebler A., Stadler R., Steuer K-H., Stober J., Streibl B., Strumberger E., Suttrop W., Tardini G., Tichmann C., Treutterer W., Troester C., Urso L., Vainonen-Ahlgren E., Varela P., Vermare L., Volpe F., Wagner D., Wigger C., Wischmeier M., Wolfrum E., Wuersching E., Yadikin D., Yu Q., Zasche D., Zehetbauer T., and Zilker M.

Subjects
Nuclear and High Energy Physics, Materials science, Nuclear engineering, Condensed Matter Physics, 7. Clean energy, 01 natural sciences, 010305 fluids & plasmas, ASDEX Upgrade, ITER, 0103 physical sciences, tokamak physics, 010306 general physics, DEMO, nuclear fusion
Abstract

ASDEX Upgrade was operated with a fully W-covered wall in 2007 and 2008. Stationary H-modes at the ITER target values and improved H-modes with H up to 1.2 were run without any boronization. The boundary conditions set by the full W wall (high enough ELM frequency, high enough central heating and low enough power density arriving at the target plates) require significant scenario development, but will apply to ITER as well. D retention has been reduced and stationary operation with saturated wall conditions has been found. Concerning confinement, impurity ion transport across the pedestal is neoclassical, explaining the strong inward pinch of high-Z impurities in between ELMs. In improved H-mode, the width of the temperature pedestal increases with heating power, consistent with a β1/2pol,ped scaling. In the area of MHD instabilities, disruption mitigation experiments using massive Ne injection reach volume averaged values of the total electron density close to those required for runaway suppression in ITER. ECRH at the q = 2 surface was successfully applied to delay density limit disruptions. The characterization of fast particle losses due to MHD has shown the importance of different loss mechanisms for NTMs, TAEs and also beta-induced Alfven eigenmodes (BAEs). Specific studies addressing the first ITER operational phase show that O1 ECRH at the HFS assists reliable low-voltage breakdown. During ramp-up, additional heating can be used to vary li to fit within the ITER range. Confinement and power threshold in He are more favourable than in H, suggesting that He operation could allow us to assess H-mode operation in the non-nuclear phase of ITER operation.

Published
2009

37. Soluble Tumor Necrosis Factor Alpha Receptors in Sera from Leprosy Patients

Author

Peter Anding, Maria das Graca S. Cunha, Antonio P. M. Schettini, Martin E. Munk, and Stefan H. E. Kaufmann

Subjects
Adult, Male, medicine.medical_treatment, Immunology, Tuberculoid leprosy, Microbiology, Receptors, Tumor Necrosis Factor, Mice, Antigens, CD, Leprosy, Tumor Cells, Cultured, medicine, Animals, Humans, Receptors, Tumor Necrosis Factor, Type II, Receptor, Mycobacterium leprae, Host Response and Inflammation, Lepromatous leprosy, biology, Tumor Necrosis Factor-alpha, Cytotoxicity Tests, Immunologic, medicine.disease, biology.organism_classification, Leprosy, Tuberculoid, In vitro, Infectious Diseases, Cytokine, Solubility, Receptors, Tumor Necrosis Factor, Type I, Female, Parasitology, Tumor necrosis factor alpha
Abstract

Serum levels of soluble tumor necrosis factor alpha receptor I (sTNF-RI) were elevated in patients with lepromatous (LL) reactional-state type II leprosy, and sTNF-RII levels were increased in patients with full tuberculoid (TT) or LL type II leprosy. The sTNF-R in sera from patients with type II leprosy, but not other forms of leprosy, inhibited recombinant TNF cytolytic activities in vitro. This suggests that sTNF-R regulatory activities are partially impaired in patients with leprosy.

Published
1999

38. Plasma wall interaction and its implication in an all tungsten divertor tokamak. Invited Paper

Author

Neu, R., Balden, M., Bobkov, V., Dux, R., Gruber, O., Herrmann, A., Kallenbach, A., Kaufmann, M., Maggi, C. F., Maier, H., Müller, H. W., Pütterich, T., Pugno, R., Rohde, V., Sips, A. C. C., Stober, J., Suttrop, W., Angioni, C., Atanasiu, C. V., Becker, W., Behler, K., Behringer, K., Bergmann, A., Bertoncelli, T., Bilato, R., Bottino, A., Brambilla, M., Braun, F., Buhler, A., Chankin, A., Conway, G., Coster, D. P., de Marne, P., Dietrich, S., Dimova, K., Drube, R., Eich, T., Engelhardt, K., Fahrbach, H.-U., Fantz, U., Fattorini, L., Fink, J., Fischer, R., Flaws, A., Franzen, P., Fuchs, J. C., Gal, K., Garcia Munoz, M., Gemisic-Adamov, M., Giannone, L., Gori, S., da Graca, S., Greuner, H., Gude, A., Günter, S., Haas, G., Harhausen, J., Heinemann, B., Hicks, N., Hobirk, J., Holtum, D., Hopf, C., Horton, L., Huart, M., Igochine, V., Kalvin, S., Kardaun, O., Kick, M., Kocsis, G., Kollotzek, H., Konz, C., Krieger, K., Kurki-Suonio, T., Kurzan, B., Lackner, K., Lang, P. T., Lauber, P., Laux, M., Likonen, J., Liu, L., Lohs, A., Mank, K., Manini, A., Manso, M.-E., Maraschek, M., Martin, P., Martin, Y., Mayer, M., McCarthy, P., McCormick, K., Meister, H., Meo, F., Merkel, P., Merkel, R., Mertens, V., Merz, F., Meyer, H., Mlynek, M., Monaco, F., Murmann, H., Neu, G., Neuhauser, J., Nold, B., Noterdaeme, J.-M., Pautasso, G., Pereverzev, G., Poli, E., Pueschel, M., Raupp, G., Reich, M., Reiter, B., Ribeiro, T., Riedl, R., Roth, J., Rott, M., Ryter, F., Sandmann, W., Santos, J., Sassenberg, K., Scarabosio, A., Schall, G., Schirmer, J., Schmid, A., Schneider, W., Schramm, G., Schrittwieser, R., Schustereder, W., Schweinzer, J., Schweizer, S., Scott, B., Seidel, U., Serra, F., Sertoli, M., Sigalov, A., Silva, A., Speth, E., Stäbler, A., Steuer, K.-H., Strumberger, E., Tardini, G., Tichmann, C., Treutterer, W., Tröster, C., Urso, L., Vainonen-Ahlgren, E., Varela, P., Vermare, L., Wagner, D., Wischmeier, M., Wolfrum, E., Würsching, E., Yadikin, D., Yu, Q., Zasche, D., Zehetbauer, T., Zilker, M., and Zohm, H.

Published
2007

39. Interaction of energetic particles with large and small scale instabilities

Author

Günter, S., Conway, G., da Graca, S., Fahrbach, H.-U., Forest, C., Garcia Munoz, M., Hauff, T., Hobirk, J., Igochine, V., Jenko, F., Lackner, K., Lauber, P., McCarthy, P., Maraschek, M., Martin, P., Poli, E., Sassenberg, K., Strumberger, E., Tardini, G., Wolfrum, E., Zohm, H., and ASDEX Upgrade Team

Published
2007

41. Overview of ASDEX Upgrade results

Author

Stroth, U, Adamek, J, Aho Mantila, L, Akaslompolo, S, Amdor, C, Angioni, C, Balden, M, Bardin, S, Orte, L, Behler, K, Belonohy, E, Bergmann, A, Bernert, M, Bilato, R, Birkenmeier, G, Bobkov, V, Boom, J, Bottereau, C, Bottino, A, Braun, F, Brezinsek, S, Brochard, T, Bruedgam, M, Buhler, A, Burckhart, A, Casson, F, Chankin, A, Chapman, I, Clairet, F, Classen, I, Coenen, J, Conway, G, Coster, D, Curran, D, da Silva, F, de Marne, P, D'Inca, R, Douai, D, Drube, R, Dunne, M, Dux, R, Eich, T, Eixenberger, H, Endstrasser, N, Engelhardt, K, Esposito, B, Fable, E, Fischer, R, Fuenfgelder, H, Fuchs, J, Gal, K, Munoz, M, Geiger, B, Giannone, L, Goerler, T, da Graca, S, Greuner, H, Gruber, O, Gude, A, Guimarais, L, Guenter, S, Haas, G, Hakola, A, Hangan, D, Happel, T, Haertl, T, Hauff, T, Heinemann, B, Herrmann, A, Hobirk, J, Hoehnle, H, Hoelzl, M, Hopf, C, Houben, A, Igochine, V, Ionita, C, Janzer, A, Jenko, F, Kantor, M, Kaesemann, C, Kallenbach, A, Kalvin, S, Kappatou, A, Kardaun, O, Kasparek, W, Kaufmann, M, Kirk, A, Klingshirn, H, Kocan, M, Kocsis, G, Konz, C, Koslowski, R, Krieger, K, Kubic, M, Kurki Suonio, T, Kurzan, B, Lackner, K, Lang, P, Lauber, P, Laux, M, Lazaros, A, Leipold, F, Leuterer, F, Lindig, S, Lisgo, S, Lohs, A, Lunt, T, Maier, H, Makkonen, T, Mank, K, Manso, M, Maraschek, M, Mayer, M, Mccarthy, P, Mcdermott, R, Mehlmann, F, Meister, H, Menchero, L, Meo, F, Merkel, P, Merkel, R, Mertens, V, Merz, F, Mlynek, A, Monaco, F, Mueller, S, Mueller, H, Muenich, M, Neu, G, Neu, R, Neuwirth, D, Nocente, M, Nold, B, Noterdaeme, J, Pautasso, G, Pereverzev, G, Ploeckl, B, Podoba, Y, Pompon, F, Poli, E, Polozhiy, K, Potzel, S, Pueschel, M, Puetterich, T, Rathgeber, S, Raupp, G, Reich, M, Reimold, F, Ribeiro, T, Riedl, R, Rohde, V, Rooij, G, Roth, J, Rott, M, Ryter, F, Salewski, M, Santos, J, Sauter, P, Scarabosio, A, Schall, G, Schmid, K, Schneider, P, Schneider, W, Schrittwieser, R, Schubert, M, Schweinzer, J, Scott, B, Sempf, M, Sertoli, M, Siccinio, M, Sieglin, B, Sigalov, A, Silva, A, Sommer, F, Staebler, A, Stober, J, Streibl, B, Strumberger, E, Sugiyama, K, Suttrop, W, Tala, T, Tardini, G, Teschke, M, Tichmann, C, Told, D, Treutterer, W, Tsalas, M, Van Zeeland, M, Varela, P, Veres, G, Vicente, J, Vianello, N, Vierle, T, Viezzer, E, Viola, B, Vorpahl, C, Wachowski, M, Wagner, D, Wauters, T, Weller, A, Wenninger, R, Wieland, B, Willensdorfer, M, Wischmeier, M, Wolfrum, E, Wuersching, E, Yu, Q, Zammuto, I, Zasche, D, Zehetbauer, T, Zhang, Y, Zilker, M, Zohm, H, McCarthy, P, McDermott, R, Zohm, H., NOCENTE, MASSIMO, Stroth, U, Adamek, J, Aho Mantila, L, Akaslompolo, S, Amdor, C, Angioni, C, Balden, M, Bardin, S, Orte, L, Behler, K, Belonohy, E, Bergmann, A, Bernert, M, Bilato, R, Birkenmeier, G, Bobkov, V, Boom, J, Bottereau, C, Bottino, A, Braun, F, Brezinsek, S, Brochard, T, Bruedgam, M, Buhler, A, Burckhart, A, Casson, F, Chankin, A, Chapman, I, Clairet, F, Classen, I, Coenen, J, Conway, G, Coster, D, Curran, D, da Silva, F, de Marne, P, D'Inca, R, Douai, D, Drube, R, Dunne, M, Dux, R, Eich, T, Eixenberger, H, Endstrasser, N, Engelhardt, K, Esposito, B, Fable, E, Fischer, R, Fuenfgelder, H, Fuchs, J, Gal, K, Munoz, M, Geiger, B, Giannone, L, Goerler, T, da Graca, S, Greuner, H, Gruber, O, Gude, A, Guimarais, L, Guenter, S, Haas, G, Hakola, A, Hangan, D, Happel, T, Haertl, T, Hauff, T, Heinemann, B, Herrmann, A, Hobirk, J, Hoehnle, H, Hoelzl, M, Hopf, C, Houben, A, Igochine, V, Ionita, C, Janzer, A, Jenko, F, Kantor, M, Kaesemann, C, Kallenbach, A, Kalvin, S, Kappatou, A, Kardaun, O, Kasparek, W, Kaufmann, M, Kirk, A, Klingshirn, H, Kocan, M, Kocsis, G, Konz, C, Koslowski, R, Krieger, K, Kubic, M, Kurki Suonio, T, Kurzan, B, Lackner, K, Lang, P, Lauber, P, Laux, M, Lazaros, A, Leipold, F, Leuterer, F, Lindig, S, Lisgo, S, Lohs, A, Lunt, T, Maier, H, Makkonen, T, Mank, K, Manso, M, Maraschek, M, Mayer, M, Mccarthy, P, Mcdermott, R, Mehlmann, F, Meister, H, Menchero, L, Meo, F, Merkel, P, Merkel, R, Mertens, V, Merz, F, Mlynek, A, Monaco, F, Mueller, S, Mueller, H, Muenich, M, Neu, G, Neu, R, Neuwirth, D, Nocente, M, Nold, B, Noterdaeme, J, Pautasso, G, Pereverzev, G, Ploeckl, B, Podoba, Y, Pompon, F, Poli, E, Polozhiy, K, Potzel, S, Pueschel, M, Puetterich, T, Rathgeber, S, Raupp, G, Reich, M, Reimold, F, Ribeiro, T, Riedl, R, Rohde, V, Rooij, G, Roth, J, Rott, M, Ryter, F, Salewski, M, Santos, J, Sauter, P, Scarabosio, A, Schall, G, Schmid, K, Schneider, P, Schneider, W, Schrittwieser, R, Schubert, M, Schweinzer, J, Scott, B, Sempf, M, Sertoli, M, Siccinio, M, Sieglin, B, Sigalov, A, Silva, A, Sommer, F, Staebler, A, Stober, J, Streibl, B, Strumberger, E, Sugiyama, K, Suttrop, W, Tala, T, Tardini, G, Teschke, M, Tichmann, C, Told, D, Treutterer, W, Tsalas, M, Van Zeeland, M, Varela, P, Veres, G, Vicente, J, Vianello, N, Vierle, T, Viezzer, E, Viola, B, Vorpahl, C, Wachowski, M, Wagner, D, Wauters, T, Weller, A, Wenninger, R, Wieland, B, Willensdorfer, M, Wischmeier, M, Wolfrum, E, Wuersching, E, Yu, Q, Zammuto, I, Zasche, D, Zehetbauer, T, Zhang, Y, Zilker, M, Zohm, H, McCarthy, P, McDermott, R, Zohm, H., and NOCENTE, MASSIMO

Abstract

The medium size divertor tokamak ASDEX Upgrade (major and minor radii 1.65 m and 0.5 m, respectively, magnetic-field strength 2.5 T) possesses flexible shaping and versatile heating and current drive systems. Recently the technical capabilities were extended by increasing the electron cyclotron resonance heating (ECRH) power, by installing 2 × 8 internal magnetic perturbation coils, and by improving the ion cyclotron range of frequency compatibility with the tungsten wall. With the perturbation coils, reliable suppression of large type-I edge localized modes (ELMs) could be demonstrated in a wide operational window, which opens up above a critical plasma pedestal density. The pellet fuelling efficiency was observed to increase which gives access to H-mode discharges with peaked density profiles at line densities clearly exceeding the empirical Greenwald limit. Owing to the increased ECRH power of 4 MW, H-mode discharges could be studied in regimes with dominant electron heating and low plasma rotation velocities, i.e. under conditions particularly relevant for ITER. The ion-pressure gradient and the neoclassical radial electric field emerge as key parameters for the transition. Using the total simultaneously available heating power of 23 MW, high performance discharges have been carried out where feed-back controlled radiative cooling in the core and the divertor allowed the divertor peak power loads to be maintained below 5 MW m -2. Under attached divertor conditions, a multi-device scaling expression for the power-decay length was obtained which is independent of major radius and decreases with magnetic field resulting in a decay length of 1 mm for ITER. At higher densities and under partially detached conditions, however, a broadening of the decay length is observed. In discharges with density ramps up to the density limit, the divertor plasma shows a complex behaviour with a localized high-density region in the inner divertor before the outer divertor detaches.

Published
2013

43. Overview of ASDEX Upgrade results

Author

Kallenbach, A., Adamek, J., Aho-Mantila, L., Äkäslompolo, S., Angioni, C., Atanasiu, C.V., Balden, M., Behler, K., Belonohy, E., Bergmann, A., Bernert, M., Bilato, R., Bobkov, V., Boom, J., Bottino, A., Braun, F., Brüdgam, M., Buhler, A., Burckhart, A., Chankin, A., Classen, I.G.J., Conway, G.D., Coster, D.P., de Marné, P., D'Inca, R., Drube, R., Dux, R., Eich, T., Endstrasser, N., Engelhardt, K., Esposito, B., Fable, E., Fahrbach, H.-U., Fattorini, L., Fischer, R., Flaws, A., Fünfgelder, H., Fuchs, J.C., Gál, K., García Muñoz, M., Geiger, B., Gemisic Adamov, M., Giannone, L., Giroud, C., Görler, T., da Graca, S., Greuner, H., Gruber, O., Gude, A., Günter, S., Haas, G., Hakola, A.H., Hangan, D., Happel, T., Hauff, T., Heinemann, B., Herrmann, A., Hicks, N., Hobirk, J., Höhnle, H., Hölzl, M., Hopf, C., Horton, L., Huart, M., Igochine, V., Ionita, C., Janzer, A., Jenko, F., Käsemann, C.-P., Kálvin, S., Kardaun, O., Kaufmann, M., Kirk, A., Klingshirn, H.-J., Kocan, M., Kocsis, G., Kollotzek, H., Konz, C., Koslowski, R., Krieger, K., Kurki-Suonio, T., Kurzan, B., Lackner, K., Lang, P.T., Lauber, P., Laux, M., Leipold, Frank, Leuterer, F., Lohs, A., Luhmann, N.C., Jr, Lunt, T., Lyssoivan, A., Maier, H., Maggi, C., Mank, K., Manso, M.-E., Maraschek, M., Martin, P., Mayer, M., McCarthy, P.J., McDermott, R., Meister, H., Menchero, L., Meo, Fernando, Merkel, P., Merkel, R., Mertens, V., Merz, F., Mlynek, A., Monaco, F., Müller, H.W., Münich, M., Murmann, H., Neu, G., Neu, R., Nold, B., Noterdaeme, J.-M., Park, H.K., Pautasso, G., Pereverzev, G., Podoba, Y., Pompon, F., Poli, E., Polochiy, K., Potzel, S., Prechtl, M., Püschel, M.J., Pütterich, T., Rathgeber, S.K., Raupp, G., Reich, M., Reiter, B., Ribeiro, T., Riedl, R., Rohde, V., Roth, J., Rott, M., Ryter, F., Sandmann, W., Santos, J., Sassenberg, K., Sauter, P., Scarabosio, A., Schall, G., Schmid, K., Schneider, P.A., Schneider, W., Schramm, G., Schrittwieser, R., Schweinzer, J., Scott, B., Sempf, M., Serra, F., Sertoli, M., Siccinio, M., Sigalov, A., Silva, A., Sips, A.C.C., Sommer, F., Stäbler, A., Stober, J., Streibl, B., Strumberger, E., Sugiyama, K., Suttrop, W., Szepesi, T., Tardini, G., Tichmann, C., Told, D., Treutterer, W., Urso, L., Varela, P., Vincente, J., Vianello, N., Vierle, T., Viezzer, E., Vorpahl, C., Wagner, D., Weller, A., Wenninger, R., Wieland, B., Wigger, C., Willensdorfer, M., Wischmeier, M., Wolfrum, E., Würsching, E., Yadikin, D., Yu, Q., Zammuto, I., Zasche, D., Zehetbauer, T., Zhang, Y., Zilker, M., Zohm, H., Kallenbach, A., Adamek, J., Aho-Mantila, L., Äkäslompolo, S., Angioni, C., Atanasiu, C.V., Balden, M., Behler, K., Belonohy, E., Bergmann, A., Bernert, M., Bilato, R., Bobkov, V., Boom, J., Bottino, A., Braun, F., Brüdgam, M., Buhler, A., Burckhart, A., Chankin, A., Classen, I.G.J., Conway, G.D., Coster, D.P., de Marné, P., D'Inca, R., Drube, R., Dux, R., Eich, T., Endstrasser, N., Engelhardt, K., Esposito, B., Fable, E., Fahrbach, H.-U., Fattorini, L., Fischer, R., Flaws, A., Fünfgelder, H., Fuchs, J.C., Gál, K., García Muñoz, M., Geiger, B., Gemisic Adamov, M., Giannone, L., Giroud, C., Görler, T., da Graca, S., Greuner, H., Gruber, O., Gude, A., Günter, S., Haas, G., Hakola, A.H., Hangan, D., Happel, T., Hauff, T., Heinemann, B., Herrmann, A., Hicks, N., Hobirk, J., Höhnle, H., Hölzl, M., Hopf, C., Horton, L., Huart, M., Igochine, V., Ionita, C., Janzer, A., Jenko, F., Käsemann, C.-P., Kálvin, S., Kardaun, O., Kaufmann, M., Kirk, A., Klingshirn, H.-J., Kocan, M., Kocsis, G., Kollotzek, H., Konz, C., Koslowski, R., Krieger, K., Kurki-Suonio, T., Kurzan, B., Lackner, K., Lang, P.T., Lauber, P., Laux, M., Leipold, Frank, Leuterer, F., Lohs, A., Luhmann, N.C., Jr, Lunt, T., Lyssoivan, A., Maier, H., Maggi, C., Mank, K., Manso, M.-E., Maraschek, M., Martin, P., Mayer, M., McCarthy, P.J., McDermott, R., Meister, H., Menchero, L., Meo, Fernando, Merkel, P., Merkel, R., Mertens, V., Merz, F., Mlynek, A., Monaco, F., Müller, H.W., Münich, M., Murmann, H., Neu, G., Neu, R., Nold, B., Noterdaeme, J.-M., Park, H.K., Pautasso, G., Pereverzev, G., Podoba, Y., Pompon, F., Poli, E., Polochiy, K., Potzel, S., Prechtl, M., Püschel, M.J., Pütterich, T., Rathgeber, S.K., Raupp, G., Reich, M., Reiter, B., Ribeiro, T., Riedl, R., Rohde, V., Roth, J., Rott, M., Ryter, F., Sandmann, W., Santos, J., Sassenberg, K., Sauter, P., Scarabosio, A., Schall, G., Schmid, K., Schneider, P.A., Schneider, W., Schramm, G., Schrittwieser, R., Schweinzer, J., Scott, B., Sempf, M., Serra, F., Sertoli, M., Siccinio, M., Sigalov, A., Silva, A., Sips, A.C.C., Sommer, F., Stäbler, A., Stober, J., Streibl, B., Strumberger, E., Sugiyama, K., Suttrop, W., Szepesi, T., Tardini, G., Tichmann, C., Told, D., Treutterer, W., Urso, L., Varela, P., Vincente, J., Vianello, N., Vierle, T., Viezzer, E., Vorpahl, C., Wagner, D., Weller, A., Wenninger, R., Wieland, B., Wigger, C., Willensdorfer, M., Wischmeier, M., Wolfrum, E., Würsching, E., Yadikin, D., Yu, Q., Zammuto, I., Zasche, D., Zehetbauer, T., Zhang, Y., Zilker, M., and Zohm, H.

Abstract

The ASDEX Upgrade programme is directed towards physics input to critical elements of the ITER design and the preparation of ITER operation, as well as addressing physics issues for a future DEMO design. After the finalization of the tungsten coating of the plasma facing components, the re-availability of all flywheel-generators allowed high-power operation with up to 20 MW heating power at Ip up to 1.2 MA. Implementation of alternative ECRH schemes (140 GHz O2- and X3-mode) facilitated central heating above ne = 1.2 × 1020 m−3 and low q95 operation at Bt = 1.8 T. Central O2-mode heating was successfully used in high P/R discharges with 20 MW total heating power and divertor load control with nitrogen seeding. Improved energy confinement is obtained with nitrogen seeding both for type-I and type-III ELMy conditions. The main contributor is increased plasma temperature, no significant changes in the density profile have been observed. This behaviour may be explained by higher pedestal temperatures caused by ion dilution in combination with a pressure limited pedestal and hollow nitrogen profiles. Core particle transport simulations with gyrokinetic calculations have been benchmarked by dedicated discharges using variations of the ECRH deposition location. The reaction of normalized electron density gradients to variations of temperature gradients and the Te/Ti ratio could be well reproduced. Doppler reflectometry studies at the L–H transition allowed the disentanglement of the interplay between the oscillatory geodesic acoustic modes, turbulent fluctuations and the mean equilibrium E × B flow in the edge negative Er well region just inside the separatrix. Improved pedestal diagnostics revealed also a refined picture of the pedestal transport in the fully developed H-mode type-I ELM cycle. Impurity ion transport turned out to be neoclassical in between ELMs. Electron and energy transport remain anomalous, but exhibit different recovery time scales after an ELM. After

Published
2011

44. Overview of ASDEX Upgrade results

Author

Stroth, U., primary, Adamek, J., additional, Aho-Mantila, L., additional, Äkäslompolo, S., additional, Amdor, C., additional, Angioni, C., additional, Balden, M., additional, Bardin, S., additional, Barrera Orte, L., additional, Behler, K., additional, Belonohy, E., additional, Bergmann, A., additional, Bernert, M., additional, Bilato, R., additional, Birkenmeier, G., additional, Bobkov, V., additional, Boom, J., additional, Bottereau, C., additional, Bottino, A., additional, Braun, F., additional, Brezinsek, S., additional, Brochard, T., additional, Brüdgam, M., additional, Buhler, A., additional, Burckhart, A., additional, Casson, F.J., additional, Chankin, A., additional, Chapman, I., additional, Clairet, F., additional, Classen, I.G.J., additional, Coenen, J.W., additional, Conway, G.D., additional, Coster, D.P., additional, Curran, D., additional, da Silva, F., additional, de Marné, P., additional, D'Inca, R., additional, Douai, D., additional, Drube, R., additional, Dunne, M., additional, Dux, R., additional, Eich, T., additional, Eixenberger, H., additional, Endstrasser, N., additional, Engelhardt, K., additional, Esposito, B., additional, Fable, E., additional, Fischer, R., additional, Fünfgelder, H., additional, Fuchs, J.C., additional, Gál, K., additional, García Muñoz, M., additional, Geiger, B., additional, Giannone, L., additional, Görler, T., additional, da Graca, S., additional, Greuner, H., additional, Gruber, O., additional, Gude, A., additional, Guimarais, L., additional, Günter, S., additional, Haas, G., additional, Hakola, A.H., additional, Hangan, D., additional, Happel, T., additional, Härtl, T., additional, Hauff, T., additional, Heinemann, B., additional, Herrmann, A., additional, Hobirk, J., additional, Höhnle, H., additional, Hölzl, M., additional, Hopf, C., additional, Houben, A., additional, Igochine, V., additional, Ionita, C., additional, Janzer, A., additional, Jenko, F., additional, Kantor, M., additional, Käsemann, C.-P., additional, Kallenbach, A., additional, Kálvin, S., additional, Kappatou, A., additional, Kardaun, O., additional, Kasparek, W., additional, Kaufmann, M., additional, Kirk, A., additional, Klingshirn, H.-J., additional, Kocan, M., additional, Kocsis, G., additional, Konz, C., additional, Koslowski, R., additional, Krieger, K., additional, Kubic, M., additional, Kurki-Suonio, T., additional, Kurzan, B., additional, Lackner, K., additional, Lang, P.T., additional, Lauber, P., additional, Laux, M., additional, Lazaros, A., additional, Leipold, F., additional, Leuterer, F., additional, Lindig, S., additional, Lisgo, S., additional, Lohs, A., additional, Lunt, T., additional, Maier, H., additional, Makkonen, T., additional, Mank, K., additional, Manso, M.-E., additional, Maraschek, M., additional, Mayer, M., additional, McCarthy, P.J., additional, McDermott, R., additional, Mehlmann, F., additional, Meister, H., additional, Menchero, L., additional, Meo, F., additional, Merkel, P., additional, Merkel, R., additional, Mertens, V., additional, Merz, F., additional, Mlynek, A., additional, Monaco, F., additional, Müller, S., additional, Müller, H.W., additional, Münich, M., additional, Neu, G., additional, Neu, R., additional, Neuwirth, D., additional, Nocente, M., additional, Nold, B., additional, Noterdaeme, J.-M., additional, Pautasso, G., additional, Pereverzev, G., additional, Plöckl, B., additional, Podoba, Y., additional, Pompon, F., additional, Poli, E., additional, Polozhiy, K., additional, Potzel, S., additional, Püschel, M.J., additional, Pütterich, T., additional, Rathgeber, S.K., additional, Raupp, G., additional, Reich, M., additional, Reimold, F., additional, Ribeiro, T., additional, Riedl, R., additional, Rohde, V., additional, Rooij, G. v., additional, Roth, J., additional, Rott, M., additional, Ryter, F., additional, Salewski, M., additional, Santos, J., additional, Sauter, P., additional, Scarabosio, A., additional, Schall, G., additional, Schmid, K., additional, Schneider, P.A., additional, Schneider, W., additional, Schrittwieser, R., additional, Schubert, M., additional, Schweinzer, J., additional, Scott, B., additional, Sempf, M., additional, Sertoli, M., additional, Siccinio, M., additional, Sieglin, B., additional, Sigalov, A., additional, Silva, A., additional, Sommer, F., additional, Stäbler, A., additional, Stober, J., additional, Streibl, B., additional, Strumberger, E., additional, Sugiyama, K., additional, Suttrop, W., additional, Tala, T., additional, Tardini, G., additional, Teschke, M., additional, Tichmann, C., additional, Told, D., additional, Treutterer, W., additional, Tsalas, M., additional, Van Zeeland, M. A., additional, Varela, P., additional, Veres, G., additional, Vicente, J., additional, Vianello, N., additional, Vierle, T., additional, Viezzer, E., additional, Viola, B., additional, Vorpahl, C., additional, Wachowski, M., additional, Wagner, D., additional, Wauters, T., additional, Weller, A., additional, Wenninger, R., additional, Wieland, B., additional, Willensdorfer, M., additional, Wischmeier, M., additional, Wolfrum, E., additional, Würsching, E., additional, Yu, Q., additional, Zammuto, I., additional, Zasche, D., additional, Zehetbauer, T., additional, Zhang, Y., additional, Zilker, M., additional, and Zohm, H., additional

Published
2013
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45. Plasma wall interaction and its implication in an all tungsted divertor tokamak

Author

Neu, R., Balden, M., Bobkov, V., Dux, R., Gruber, O., Herrmann, A., Kallenbach, A., Kaufmann, M., Maggi, C.F., Maier, H., Müller, H.W., Pütterich, T., Pugno, R., Rohde, V., Sips, A.C.C., Stober, J., Suttrop, W., Angioni, C., Atanasiu, C.V., Becker, W., Behler, K., Behringer, K., Bergmann, A., Bertoncelli, T., Bilato, R., Bottino, A., Brambilla, M., Braun, F., Buhler, A., Chankin, A., Conway, G., Coster, D.P., Marne, P. de, Dietrich, S., Dimova, K., Drube, R., Eich, T., Engelhardt, K., Fahrbach, H.-U., Fantz, U., Fattorini, L., Fink, J., Fischer, R., Flaws, A., Franzen, P., Fuchs, J.C., Gal, K., Munoz, M.G, Gemisic-Adamov, M., Giannone, L., Gori, S., Graca, S. da, Greuner, H., Gude, A., Günter, S., Haas, G., Harhausen, J., Heinemann, B., Hicks, N., Hobirk, J., Holtum, D., Hopf, C., Horton, L., Huart, M., Igochine, V., Kalvin, S., Kardaun, O., Kick, M., Kocsis, G., Kollotzek, H., Konz, C., Krieger, K., Kurki-Suonio, T., Kurzan, B., Lackner, K., Lang, P.T.;Lauber, Laux, M., Likonen, J., Liu, L., Lohs, A., Mank, K., Manini, A., Manso, M.-E., Maraschek, M., Martin, P., Martin, Y., Mayer, M., McCarthy, P., McCormick, K., Meister, H., Meo, Fernando, Merkel, P., Merkel, R., Mertens, V., Merz, F., Meyer, H., Mlynek, M., Monaco, F., Murmann1, H., Neu, G., Neuhauser, J., Nold, B., Noterdaeme, J.-M., Pautasso, G., Pereverzev, G., Poli, E., Püschel1, M., Raupp, G., Reich, M., Reiter, B., Ribeiro, T., Riedl, R., Roth, J., Rott, M., Ryter, F., Sandmann, W., Santos, J., Sassenberg, K., Scarabosio, A., Schall, G., Schirmer, J., Schmid, A., Schneider, W., Schramm, G., Schrittwieser, R., Schustereder, W., Schweinzer, J., Schweizer, S., Scott, B., Seidel, U., Serra, F., Sertoli, M., Sigalov, A., Silva, A., Speth, E., Stäbler, A., Steuer, K.-H., Strumberger, E., Tardini, G., Tichmann, C., Treutterer, W., Tröster, C., Urso, L., Vainonen-Ahlgren, E., Varela, P., Vermare, L., Wagner, D., Wischmeier, M., Wolfrum, E., Würsching, E., Yadikin, D., Yu, Q., Zasche, D., Zehetbauer, T., Zilker, M., Zohm, H., Neu, R., Balden, M., Bobkov, V., Dux, R., Gruber, O., Herrmann, A., Kallenbach, A., Kaufmann, M., Maggi, C.F., Maier, H., Müller, H.W., Pütterich, T., Pugno, R., Rohde, V., Sips, A.C.C., Stober, J., Suttrop, W., Angioni, C., Atanasiu, C.V., Becker, W., Behler, K., Behringer, K., Bergmann, A., Bertoncelli, T., Bilato, R., Bottino, A., Brambilla, M., Braun, F., Buhler, A., Chankin, A., Conway, G., Coster, D.P., Marne, P. de, Dietrich, S., Dimova, K., Drube, R., Eich, T., Engelhardt, K., Fahrbach, H.-U., Fantz, U., Fattorini, L., Fink, J., Fischer, R., Flaws, A., Franzen, P., Fuchs, J.C., Gal, K., Munoz, M.G, Gemisic-Adamov, M., Giannone, L., Gori, S., Graca, S. da, Greuner, H., Gude, A., Günter, S., Haas, G., Harhausen, J., Heinemann, B., Hicks, N., Hobirk, J., Holtum, D., Hopf, C., Horton, L., Huart, M., Igochine, V., Kalvin, S., Kardaun, O., Kick, M., Kocsis, G., Kollotzek, H., Konz, C., Krieger, K., Kurki-Suonio, T., Kurzan, B., Lackner, K., Lang, P.T.;Lauber, Laux, M., Likonen, J., Liu, L., Lohs, A., Mank, K., Manini, A., Manso, M.-E., Maraschek, M., Martin, P., Martin, Y., Mayer, M., McCarthy, P., McCormick, K., Meister, H., Meo, Fernando, Merkel, P., Merkel, R., Mertens, V., Merz, F., Meyer, H., Mlynek, M., Monaco, F., Murmann1, H., Neu, G., Neuhauser, J., Nold, B., Noterdaeme, J.-M., Pautasso, G., Pereverzev, G., Poli, E., Püschel1, M., Raupp, G., Reich, M., Reiter, B., Ribeiro, T., Riedl, R., Roth, J., Rott, M., Ryter, F., Sandmann, W., Santos, J., Sassenberg, K., Scarabosio, A., Schall, G., Schirmer, J., Schmid, A., Schneider, W., Schramm, G., Schrittwieser, R., Schustereder, W., Schweinzer, J., Schweizer, S., Scott, B., Seidel, U., Serra, F., Sertoli, M., Sigalov, A., Silva, A., Speth, E., Stäbler, A., Steuer, K.-H., Strumberger, E., Tardini, G., Tichmann, C., Treutterer, W., Tröster, C., Urso, L., Vainonen-Ahlgren, E., Varela, P., Vermare, L., Wagner, D., Wischmeier, M., Wolfrum, E., Würsching, E., Yadikin, D., Yu, Q., Zasche, D., Zehetbauer, T., Zilker, M., and Zohm, H.

Published
2007

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