150 results on '"Grabenhenrich, L."'
Search Results
2. NFDI4Health – nationale Forschungsdateninfrastruktur für personenbezogene Gesundheitsdaten
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Fluck, J., Lindstädt, B., Ahrens, W., Beyan, O., Buchner, B., Darms, J., Depping, R., Dierkes, J., Fröhlich, H., Gehrke, J., Golebiewski, M., Grabenhenrich, L., Hahn, H.K., Kirsten, T., Klammt, S., Kusch, H., Löbe, M., Löffler, M., Meineke, F., Müller, W., Neuhausen, H., Nöthlings, U., Pischon, T., Prasser, F., Sax, U., Schmidt, C.O., Schulze, M., Semler, S.C., Thun, S., Waltemath, D., Wieler, L.H., Zeeb, H., Pigeot, I., and Publica
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Cardiovascular and Metabolic Diseases ,ddc:340 - Abstract
Epidemiologische und klinische Studien sind standardisiert und gut dokumentiert, jedoch erfüllen Studienprotokolle, eingesetzte Erhebungsinstrumente und erhobene Daten die Anforderungen der FAIR-Prinzipien nicht in ausreichendem Maße. NFDI4Health wird daher eine Struktur schaffen, die eine zentrale Suche nach existierenden, dezentral verwalteten Datenkörpern und zugehörigen Dokumenten sowie einen FAIRen Zugang zu diesen erleichtert. Dazu werden die Auffindbarkeit und der Zugang zu strukturierten Gesundheitsdaten aus Registern, administrativen Gesundheitsdatenbanken, klinischen und epidemiologischen sowie Public Health-Studien verbessert und die Qualität und Harmonisierung der zugrundeliegenden Daten optimiert. Eine weitere Herausforderung entsteht durch die Verwendung personenbezogener Gesundheitsdaten. Diese sind hoch sensibel, so dass ihre Nutzung restriktive Datenschutzbestimmungen und informierte Einwilligungserklärungen der StudienteilnehmerInnen erfordert, was jedoch ihre Wiederverwendbarkeit einschränkt. NFDI4Health zielt daher darauf ab, den Austausch und die Verknüpfung von personenbezogenen Gesundheitsdaten sowie verteilte Datenanalysen unter Einhaltung datenschutzrechtlicher und ethischer Bestimmungen zu erleichtern. Um dies möglichst effizient zu erreichen, wird NFDI4Health die Entwicklung neuer, maschinenprozessierbarer Zustimmungsmöglichkeiten sowie innovativer Datenzugriffsservices auf Grundlage der FAIRPrinzipien vorantreiben und die Interoperabilität von IT-Lösungen für Metadatenrepositorien stärken. Komplementiert wird dies durch die Entwicklung entsprechender Angebote für Training und Ausbildung, um der Herausforderung der Umsetzung der Lösungen in den Universitäten und Forschungseinrichtungen zu begegnen. Schließlich wird durch die gemeinsame Arbeit in der NFDI4Health die Kooperation zwischen klinischer und epidemiologischer/Public Health-Forschung gestärkt.
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- 2022
3. A new framework for the documentation and interpretation of oral food challenges in population‐based and clinical research
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Grabenhenrich, L. B., Reich, A., Bellach, J., Trendelenburg, V., Sprikkelman, A. B., Roberts, G., Grimshaw, K. E. C., Sigurdardottir, S., Kowalski, M. L., Papadopoulos, N. G., Quirce, S., Dubakiene, R., Niggemann, B., Fernández‐Rivas, M., Ballmer‐Weber, B., van Ree, R., Schnadt, S., Mills, E. N. C., Keil, T., and Beyer, K.
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- 2017
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4. Atopic Dermatitis in Infancy and Childhood
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Wahn, U., primary, Keil, T., additional, Grabenhenrich, L., additional, and Werfel, T., additional
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- 2016
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5. List of Contributors
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Aalberse, Rob C., primary, Ahrens, Birgit, additional, Allen, Katrina, additional, Arshad, Hasan, additional, Barnes, Kathleen C., additional, Bergmann, Karl E., additional, Bergmann, Renate, additional, Beyer, Kirsten, additional, Björkstén, Bengt, additional, Coleman, Amaziah, additional, van Esch, B.C.A.M., additional, Garssen, J., additional, Gern, James E., additional, Grabenhenrich, L., additional, Grüber, Christoph, additional, Heymann, Peter W., additional, Holt, Patrick, additional, Järvinen, Kirsi M., additional, Jenmalm, Maria C., additional, Keil, T., additional, Knippels, L.M.J., additional, Kopp, M.V., additional, Kostadinova, A.I., additional, Lack, Gideon, additional, Lau, Susanne, additional, Lødrup Carlsen, Karin C., additional, Matricardi, Paolo M., additional, von Mutius, Erika, additional, Penagos, Martin, additional, Pfefferle, Petra Ina, additional, Platts-Mills, Thomas, additional, Prescott, Susan L., additional, Renz, Harald, additional, Sampson, Hugh A., additional, Santos, Alexandra, additional, Schaub, Bianca, additional, Spergel, Jonathan M., additional, Tang, Mimi L.K., additional, Turner, Ronald B., additional, Vonk, M.M., additional, Wahn, U., additional, Warner, John O., additional, Werfel, T., additional, Wickman, Magnus, additional, Willemsen, L.E.M., additional, and Wood, Robert A., additional
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- 2016
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6. The Development of Allergic Rhinitis in Childhood
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Wahn, U., primary, Keil, T., additional, and Grabenhenrich, L., additional
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- 2016
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7. Incidence and natural history of henʼs egg allergy in the first 2 years of life—the EuroPrevall birth cohort study
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Xepapadaki, P., Fiocchi, A., Grabenhenrich, L., Roberts, G., Grimshaw, K. E. C., Fiandor, A., Larco, J. I., Sigurdardottir, S., Clausen, M., Papadopoulos, N. G., Dahdah, L., Mackie, A., Sprikkelman, A. B., Schoemaker, A. A., Dubakiene, R., Butiene, I., Kowalski, M. L., Zeman, K., Gavrili, S., Keil, T., and Beyer, K.
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- 2016
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8. Non-IgE mediated cowʼs milk allergy in EuroPrevall
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Grimshaw, K. E., Beyer, K., Grabenhenrich, L., Keil, T., Sprikkelman, A. B., and Roberts, G.
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- 2015
9. Is it the true incidence of IgE-cowʼs milk allergy (CMA) or CMA or IgE-CMA in some countries and CMA in others
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Katz, Y., Nowak-Wegrzyn, A., Grimshaw, K. E., Beyer, K., Grabenhenrich, L., Keil, T., Sprikkelman, A. B., and Roberts, G.
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- 2015
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10. Incidence and natural history of challenge-proven cowʼs milk allergy in European children – EuroPrevall birth cohort
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Schoemaker, A. A., Sprikkelman, A. B., Grimshaw, K. E., Roberts, G., Grabenhenrich, L., Rosenfeld, L., Siegert, S., Dubakiene, R., Rudzeviciene, O., Reche, M., Fiandor, A., Papadopoulos, N. G., Malamitsi-Puchner, A., Fiocchi, A., Dahdah, L., Sigurdardottir, S. Th., Clausen, M., Stańczyk-Przyłuska, A., Zeman, K., Mills, E. N. C., McBride, D., Keil, T., and Beyer, K.
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- 2015
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11. Predictive values of component-specific IgE for the outcome of peanut and hazelnut food challenges in children
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Beyer, K., Grabenhenrich, L., Härtl, M., Beder, A., Kalb, B., Ziegert, M., Finger, A., Harandi, N., Schlags, R., Gappa, M., Puzzo, L., Röblitz, H., Millner-Uhlemann, M., Büsing, S., Ott, H., Lange, L., and Niggemann, B.
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- 2015
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12. First European data from the network of severe allergic reactions (NORA)
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Worm, M., Moneret-Vautrin, A., Scherer, K., Lang, R., Fernandez-Rivas, M., Cardona, V., Kowalski, M. L., Jutel, M., Poziomkowska-Gesicka, I., Papadopoulos, N. G., Beyer, K., Mustakov, T., Christoff, G., Bilò, M. B., Muraro, A., Hourihane, J. O. B., and Grabenhenrich, L. B.
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- 2014
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13. Prevalence and early-life risk factors of school-age allergic multimorbidity: The EuroPrevall-iFAAM birth cohort
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Sigurdardottir, S.T. Jonasson, K. Clausen, M. Lilja Bjornsdottir, K. Sigurdardottir, S.E. Roberts, G. Grimshaw, K. Papadopoulos, N.G. Xepapadaki, P. Fiandor, A. Quirce, S. Sprikkelman, A.B. Hulshof, L. Kowalski, M.L. Kurowski, M. Dubakiene, R. Rudzeviciene, O. Bellach, J. Yürek, S. Reich, A. Erhard, S.M. Couch, P. Rivas, M.F. van Ree, R. Mills, C. Grabenhenrich, L. Beyer, K. Keil, T.
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Background: Coexistence of childhood asthma, eczema and allergic rhinitis is higher than can be expected by chance, suggesting a common mechanism. Data on allergic multimorbidity from a pan-European, population-based birth cohort study have been lacking. This study compares the prevalence and early-life risk factors of these diseases in European primary school children. Methods: In the prospective multicentre observational EuroPrevall-iFAAM birth cohort study, we used standardized questionnaires on sociodemographics, medical history, parental allergies and lifestyle, and environmental exposures at birth, 12 and 24 months. At primary school age, parents answered ISAAC-based questions on current asthma, rhinitis and eczema. Allergic multimorbidity was defined as the coexistence of at least two of these. Results: From 10,563 children recruited at birth in 8 study centres, we included data from 5,572 children (mean age 8.2 years; 51.8% boys). Prevalence estimates were as follows: asthma, 8.1%; allergic rhinitis, 13.3%; and eczema, 12.0%. Allergic multimorbidity was seen in 7.0% of the whole cohort, ranging from 1.2% (Athens, Greece) to 10.9% (Madrid, Spain). Risk factors for allergic multimorbidity, identified with AICc, included family-allergy-score, odds ratio (OR) 1.50 (95% CI 1.32–1.70) per standard deviation; early-life allergy symptoms, OR 2.72 (2.34–3.16) for each symptom; and caesarean birth, OR 1.35 (1.04–1.76). Female gender, OR 0.72 (0.58–0.90); older siblings, OR 0.79 (0.63–0.99); and day care, OR 0.81 (0.63–1.06) were protective factors. Conclusion: Allergic multimorbidity should be regarded as an important chronic childhood disease in Europe. Some of the associated early-life factors are modifiable and may be considered for prevention strategies. © 2021 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
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- 2021
14. COVID-19-Forschungsdaten leichter zugänglich machen - Aufbau einer bundesweiten Informationsinfrastruktur
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Schmidt, C.O., Fluck, J., Golebiewski, M., Grabenhenrich, L., Hahn, H., Kirsten, T., Klammt, S., Löbe, M., Sax, U., Thun, S., Pigeot, I., and Publica
- Abstract
Public-Health-Forschung, epidemiologische und klinische Studien sind erforderlich, um die COVID-19-Pandemie besser zu verstehen und geeignete Maßnahmen zu ergreifen. Daher wurden auch in Deutschland zahlreiche Forschungsprojekte initiiert. Zum heutigen Zeitpunkt ist es ob der Fülle an Informationen jedoch kaum noch möglich, einen Überblick über die vielfältigen Forschungsaktivitäten und deren Ergebnisse zu erhalten. Im Rahmen der Initiative ""Nationale Forschungsdateninfrastruktur für personenbezogene Gesundheitsdaten"" (NFDI4Health) schafft die ""Task Force COVID-19"" einen leichteren Zugang zu SARS-CoV-2- und COVID-19-bezogenen klinischen, epidemiologischen und Public-Health-Forschungsdaten. Dabei werden die sogenannten FAIR-Prinzipien (Findable, Accessible, Interoperable, Reusable) berücksichtigt, die eine schnellere Kommunikation von Ergebnissen befördern sollen. Zu den wesentlichen Arbeitsinhalten der Taskforce gehören die Erstellung eines Studienportals mit Metadaten, Erhebungsinstrumenten, Studiendokumenten, Studienergebnissen und Veröffentlichungen sowie einer Suchmaschine für Preprint-Publikationen. Weitere Inhalte sind ein Konzept zur Verknüpfung von Forschungs- und Routinedaten, Services zum verbesserten Umgang mit Bilddaten und die Anwendung standardisierter Analyseroutinen für harmonisierte Qualitätsbewertungen. Die im Aufbau befindliche Infrastruktur erleichtert die Auffindbarkeit von und den Umgang mit deutscher COVID-19-Forschung. Die im Rahmen der NFDI4Health Task Force COVID-19 begonnenen Entwicklungen sind für weitere Forschungsthemen nachnutzbar, da die adressierten Herausforderungen generisch für die Auffindbarkeit von und den Umgang mit Forschungsdaten sind.
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- 2021
15. Individual cowʼs milk allergens as prognostic markers for tolerance development?
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Ahrens, B., Lopes de Oliveira, L. C., Grabenhenrich, L., Schulz, G., Niggemann, B., Wahn, U., and Beyer, K.
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- 2012
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16. Anaphylaxis in an emergency setting – elicitors, therapy and incidence of severe allergic reactions
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Beyer, K., Eckermann, O., Hompes, S., Grabenhenrich, L., and Worm, M.
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- 2012
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17. Outcome of oral food challenges in children in relation to symptom-eliciting allergen dose and allergen-specific IgE
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Rolinck-Werninghaus, C., Niggemann, B., Grabenhenrich, L., Wahn, U., and Beyer, K.
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- 2012
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18. The EuroPrevall birth cohort study on food allergy: baseline characteristics of 12,000 newborns and their families from nine European countries
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McBride, D., Keil, T., Grabenhenrich, L., Dubakiene, R., Drasutiene, G., Fiocchi, A., Dahdah, L., Sprikkelman, A. B., Schoemaker, A. A., Roberts, G., Grimshaw, K., Kowalski, M. L., Stanczyk-Przyluska, A., Sigurdardottir, S., Clausen, M., Papadopoulos, N. G., Mitsias, D., Rosenfeld, L., Reche, M., Pascual, C., Reich, A., Hourihane, J., Wahn, U., Mills, E. N. C., Mackie, A., and Beyer, K.
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- 2012
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19. Secondary prevention measures in anaphylaxis patients: Data from the anaphylaxis registry
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Kraft, M. Knop, M.P. Renaudin, J.-M. Scherer Hofmeier, K. Pföhler, C. Bilò, M.B. Lang, R. Treudler, R. Wagner, N. Spindler, T. Hourihane, J.O.B. Maris, I. Koehli, A. Bauer, A. Lange, L. Müller, S. Papadopoulos, N.G. Wedi, B. Moeser, A. Ensina, L.F. Fernandez-Rivas, M. Cichocka-Jarosz, E. Christoff, G. Garcia, B.E. Poziomkowska-Gęsicka, I. Cardona, V. Mustakov, T.B. Rabe, U. Mahler, V. Grabenhenrich, L. Dölle-Bierke, S. Worm, M. The Network for Online Registration of Anaphylaxis (NORA)
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Background: Patients with a history of anaphylaxis are at risk of future anaphylactic reactions. Thus, secondary prevention measures are recommended for these patients to prevent or attenuate the next reaction. Methods: Data from the Anaphylaxis Registry were analyzed to identify secondary prevention measures offered to patients who experienced anaphylaxis. Our analysis included 7788 cases from 10 European countries and Brazil. Results: The secondary prevention measures offered varied across the elicitors. A remarkable discrepancy was observed between prevention measures offered in specialized allergy centers (84% of patients were prescribed adrenaline autoinjectors following EAACI guidelines) and outside the centers: Here, EAACI guideline adherence was only 37%. In the multivariate analysis, the elicitor of the reaction, age of the patient, mastocytosis as comorbidity, severity of the reaction, and reimbursement/availability of the autoinjector influence physician's decision to prescribe one. Conclusions: Based on the low implementation of guidelines concerning secondary prevention measures outside of specialized allergy centers, our findings highlight the importance of these specialized centers and the requirement of better education for primary healthcare and emergency physicians. © 2019 The Authors. Allergy published by John Wiley & Sons Ltd.
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- 2020
20. Frequency of food allergy in school-aged children in eight European countries—The EuroPrevall-iFAAM birth cohort
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Grabenhenrich, L. Trendelenburg, V. Bellach, J. Yürek, S. Reich, A. Fiandor, A. Rivero, D. Sigurdardottir, S. Clausen, M. Papadopoulos, N.G. Xepapadaki, P. Sprikkelman, A.B. Dontje, B. Roberts, G. Grimshaw, K. Kowalski, M.L. Kurowski, M. Dubakiene, R. Rudzeviciene, O. Fernández-Rivas, M. Couch, P. Versteeg, S.A. van Ree, R. Mills, C. Keil, T. Beyer, K.
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Background: The prevalence of food allergy (FA) among European school children is poorly defined. Estimates have commonly been based on parent-reported symptoms. We aimed to estimate the frequency of FA and sensitization against food allergens in primary school children in eight European countries. Methods: A follow-up assessment at age 6-10 years of a multicentre European birth cohort based was undertaken using an online parental questionnaire, clinical visits including structured interviews and skin prick tests (SPT). Children with suspected FA were scheduled for double-blind, placebo-controlled oral food challenges (DBPCFC). Results: A total of 6105 children participated in this school-age follow-up (57.8% of 10 563 recruited at birth). For 982 of 6069 children (16.2%), parents reported adverse reactions after food consumption in the online questionnaire. Of 2288 children with parental face-to-face interviews and/or skin prick testing, 238 (10.4%) were eligible for a DBPCFC. Sixty-three foods were challenge-tested in 46 children. Twenty food challenges were positive in 17 children, including seven to hazelnut and three to peanut. Another seventy-one children were estimated to suffer FA among those who were eligible but refused DBPCFC. This yielded prevalence estimates for FA in school age between 1.4% (88 related to all 6105 participants of this follow-up) and 3.8% (88 related to 2289 with completed eligibility assessment). Interpretation: In primary school children in eight European countries, the prevalence of FA was lower than expected even though parents of this cohort have become especially aware of allergic reactions to food. There was moderate variation between centres hampering valid regional comparisons. © 2020 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd
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- 2020
21. European all-cause excess and influenza-attributable mortality in the 2017/18 season:should the burden of influenza B be reconsidered?
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Nielsen, J., Vestergaard, L. S., Richter, L., Schmid, D., Bustos, N., Asikainen, T., Trebbien, R., Denissov, G., Innos, K., Virtanen, M. J., Fouillet, A., Lytras, T., Gkolfinopoulou, K., Heiden, M. an der, Grabenhenrich, L., Uphoff, H., Paldy, A., Bobvos, J., Domegan, L., O'Donnell, J., Scortichini, M., de Martino, A., Mossong, J., England, K., Melillo, J., van Asten, L., de Lange, M. MA, Tønnessen, R., White, R. A., da Silva, S. P., Rodrigues, A. P., Larrauri, A., Mazagatos, C., Farah, A., Carnahan, A. D., Junker, C., Sinnathamby, M., Pebody, R. G., Andrews, N., Reynolds, A., McMenamin, J., Brown, C. S., Adlhoch, C., Penttinen, P., Mølbak, K., Krause, T. G., Nielsen, J., Vestergaard, L. S., Richter, L., Schmid, D., Bustos, N., Asikainen, T., Trebbien, R., Denissov, G., Innos, K., Virtanen, M. J., Fouillet, A., Lytras, T., Gkolfinopoulou, K., Heiden, M. an der, Grabenhenrich, L., Uphoff, H., Paldy, A., Bobvos, J., Domegan, L., O'Donnell, J., Scortichini, M., de Martino, A., Mossong, J., England, K., Melillo, J., van Asten, L., de Lange, M. MA, Tønnessen, R., White, R. A., da Silva, S. P., Rodrigues, A. P., Larrauri, A., Mazagatos, C., Farah, A., Carnahan, A. D., Junker, C., Sinnathamby, M., Pebody, R. G., Andrews, N., Reynolds, A., McMenamin, J., Brown, C. S., Adlhoch, C., Penttinen, P., Mølbak, K., and Krause, T. G.
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Objectives: Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause excess and influenza-attributable mortality during the season 2017/18 in Europe. Methods: Based on weekly reporting of mortality from 24 European countries or sub-national regions, representing 60% of the European population excluding the Russian and Turkish parts of Europe, we estimated age stratified all-cause excess morality using the EuroMOMO model. In addition, age stratified all-cause influenza-attributable mortality was estimated using the FluMOMO algorithm, incorporating influenza activity based on clinical and virological surveillance data, and adjusting for extreme temperatures. Results: Excess mortality was mainly attributable to influenza activity from December 2017 to April 2018, but also due to exceptionally low temperatures in February-March 2018. The pattern and extent of mortality excess was similar to the previous A(H3N2) dominated seasons, 2014/15 and 2016/17. The 2017/18 overall all-cause influenza-attributable mortality was estimated to be 25.4 (95%CI 25.0-25.8) per 100,000 population; 118.2 (116.4-119.9) for persons aged 65. Extending to the European population this translates into over-all 152,000 deaths. Conclusions: The high mortality among elderly was unexpected in an influenza B dominated season, which commonly are considered to cause mild illness, mainly among children. Even though A(H3N2) also circulated in the 2017/18 season and may have contributed to the excess mortality among the elderly, the common perception of influenza B only having a modest impact on excess mortality in the older population may need to be reconsidered.
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- 2019
22. Can dietary strategies in early life prevent childhood food allergy? A report from two iFAAM workshops
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Roberts, G., Grimshaw, K., Beyer, K. Kirsten, Boyle, R., Lack, G., Austin, M., Garcia-Larsen, V., Grabenhenrich, L., Halken, S., Keil, T., Bernhard Madsen, Charlotte, Regent, L., Schnadt, S., Szajewska, H., van Ree, R., Mills, E N C, Roberts, G., Grimshaw, K., Beyer, K. Kirsten, Boyle, R., Lack, G., Austin, M., Garcia-Larsen, V., Grabenhenrich, L., Halken, S., Keil, T., Bernhard Madsen, Charlotte, Regent, L., Schnadt, S., Szajewska, H., van Ree, R., and Mills, E N C
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Food allergy affects a small but significant number of children and adults. Food allergy is responsible for considerable morbidity and is the commonest cause of anaphylaxis in children. One of the aims of the European Union funded "Integrated Approaches to Food Allergen and Allergy Risk Management" (iFAAM) project was to improve our understanding of the best way to prevent the development of food allergy. Groups within the project worked on integrating the current prevention evidence base as well as generating new data to move our understanding forward. This paper from the iFAAM project is a unique addition to the literature on this topic as it not only outlines the recently published randomised controlled trials (as have previous reviews) but it also summarises two iFAAM-associated project workshops. These workshops focused on how we may be able to use dietary strategies in early life to prevent the development of food allergy and summarises the range of opinions amongst experts in this controversial area.
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- 2019
23. Prevalence estimates and risk factors for early childhood wheeze across europe: The europrevall birth cohort
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Selby, A. Munro, A. Grimshaw, K.E. Cornelius, V. Keil, T. Grabenhenrich, L. Clausen, M. Dubakiene, R. Fiocchi, A. Kowalski, M.L. Papadopoulos, N.G. Reche, M. Sigurdardottir, S.T. Sprikkelman, A.B. Xepapadaki, P. Mills, E.N.C. Beyer, K. Roberts1, G.
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Background Preschool wheeze is an important problem worldwide.No comparative population-based studies covering different countries have previously been undertaken.Objective T o assess the prevalence of early childhood wheeze across Europe and evaluate risk factors focusing on food allergy, breast feeding and smoke exposure.Methods I nfants from nine countries were recruited into the EuroPrevall birth cohort.At 12 and 24 months, data on wheeze, allergic signs/symptoms, feeding, smoke exposure, infections and day care attendance were collected using questionnaires.Poisson regression was used to assess risk factors for wheeze.Results 12 049 infants were recruited.Data from the second year of life were available in 8805 (73.1%).The prevalence of wheeze in the second year of life ranged from
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- 2018
24. 7 - The Development of Allergic Rhinitis in Childhood
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Wahn, U., Keil, T., and Grabenhenrich, L.
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- 2016
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25. 3 - Atopic Dermatitis in Infancy and Childhood
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Wahn, U., Keil, T., Grabenhenrich, L., and Werfel, T.
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- 2016
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26. An index for assessing activity friendliness for children in urban environments of Berlin
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Schicketanz, Juliane, Grabenhenrich, L., Lakes, T., Schicketanz, Juliane, Grabenhenrich, L., and Lakes, T.
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The physical environment strongly influences physical activity in urban settings. While walkability is frequentlyassessed for adults, an approach for mapping the friendliness of urban environments focusing on children’sactivities is not available. The aim of the presented approach was to identify supporting and limiting factorsof activity friendliness in urban environments and incorporate them into a children’s physical activity index(CAI). We conducted qualitative guided interviews with nine- to ten-year-old children and parents of primaryschool children in Berlin to identify the factors and their importance for describing activity friendliness. Accessto activity and recreational destinations, land use, traffic and road safety, and the social environment were themost prominent factors identified for the activity friendliness for children. The newly developed CAI enables adifferentiation in the activity friendliness of urban neighborhoods for children.Die urbane Umwelt beeinflusst die körperliche Aktivität ihrer Bewohner. Zur Bewertung der Fußgängerfreundlichkeit wurde für Erwachsene das Konzept der Walkability entwickelt und vielfach angewandt. Eine Methode zur Messung der Bewegungsfreundlichkeit der urbanen Umwelt für Kinder existiert jedoch nicht. Ziel dieser Studie ist die Bestimmung bewegungsfördernder und -hemmender Faktoren im urbanen Raum und eine Zusammenführung dieser in dem children’s physical activity index (CAI). Es wurden qualitative leitfadengestützte Interviews mit neun- bis zehnjährigen Kindern und Eltern von Grundschulkindern in Berlin durchgeführt, um die Faktoren und ihre Gewichtung zur Beschreibung von Bewegungsfreundlichkeit zu identifizieren. Der Zugang zu Bewegungs- und Freizeitdestinationen, Landnutzung, Straßenverkehr und Verkehrssicherheit und die soziale Umwelt waren die wichtigsten Bewegungsfreundlichkeitsfaktoren. Der entwickelte CAI ermöglicht eine differenzierte räumliche Darstellung der Bewegungsfreundlichkeit der urbanen Umwelt für
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- 2018
27. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
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Pouessel, G, Claverie, C, Labreuche, J, Renaudin, J-M, Dorkenoo, A, Eb, M, Moneret-Vautrin, A, Deschildre, A, Leteurtre, S, Grabenhenrich, L, Worm, M, Dölle, S, Scherer, K, Hutteger, I, Christensen, M, Bindslev-Jensen, C, Mortz, C, Eller, E, Kjaer, HF, Carneiro-Leão, L, Badas, J, Coimbra, A, Levy, DP, Ben-Shoshan, M, Rimon, A, Benor, S, Arends, NJT, Edelbroek, N, de Groot, H, Emons, JAM, Brand, HKA, Verhoeven, D, van Veen, LN, de Jong, NW, Noh, G, Jang, EH, Pascal, M, Dominguez, O, Piquer, M, Alvaro, M, Jimenez-Feijoo, R, Lozano, J, Machinena, A, del Mar Folqué, M, Giner, MT, Plaza, AM, Turner, P, Patel, N, Vazquez-Ortiz, M, Lindsley, S, Walker, L, Rosenberg, S, Mari, A, Alessandri, C, Giangrieco, I, Tuppo, L, Rafaiani, C, Mitterer, G, Ciancamerla, M, Ferrara, R, Bernardi, ML, Zennaro, D, Tamburrini, M, Ciardiello, MA, Harwanegg, C, Fernandez, A, Selb, R, Egenmann, P, Epstein, M, Hoffmann-Sommergruber, K, Koning, F, Lovik, M, Clare Mills, EN, Moreno, J, van Loveren, H, Wal, J-M, Diesner, S, Bergmayr, C, Pfitzner, B, Assmann, VE, Starkl, P, Endesfelder, D, Eiwegger, T, Szepfalusi, Z, Fehrenbach, H, Jensen-Jarolim, E, Hartmann, A, Pali-Schöll, I, Untersmayr, E, Wille, S, Meyer, P, Klingebiel, C, Lidholm, J, Ehrenberg, A, Östling, J, Cleach, I, Mège, J-L, Vitte, J, Aina, R, Dubiela, P, Pfeifer, S, Bublin, M, Radauer, C, Humeniuk, P, Kabasser, S, Asero, R, Bogas, G, Gomez, F, Campo, P, Salas, M, Doña, I, Barrionuevo, E, Guerrero, MA, Mayorga, C, Prieto, A, Barber, D, Torres, MJ, Jamin, A, Wangorsch, A, Ballmer, B, Vieths, S, Scheurer, S, Apostolovic, D, Mihailovic, J, Krstic, M, Starkhammar, M, Velickovic, TC, Hamsten, C, van Hage, M, van Erp, FC, Knol, EF, Kansen, HM, Pontoppidan, B, Meijer, Y, van der Ent, CK, Knulst, AC, Sayers, R, Brown, H, Custovic, A, Simpson, A, Mills, C, Schulz, J, Akkerdaas, J, Totis, M, Capt, A, Herouet-Guicheney, C, van Ree, R, Banerjee, T, Banerjee, A, Claude, M, Bouchaud, G, Lupi, R, Castan, L, Tranquet, O, Denery-Papini, S, Bodinier, M, Brossard, C, De Poi, R, Gritti, E, De Dominicis, E, Popping, B, de Laureto, PP, Palosuo, K, Kukkonen, AK, Pelkonen, A, Mäkelä, M, Lee, NA, Rost, J, Muralidharan, S, Campbell, D, Mehr, S, Nock, C, Baumert, J, Taylor, S, Mastrorilli, C, Tripodi, S, Caffarelli, C, Perna, S, Di Rienzo Businco, A, Sfika, I, Dondi, A, Bianchi, A, Dascola, CP, Ricci, G, Cipriani, F, Maiello, N, del Giudice, MM, Frediani, T, Frediani, S, Macrì, F, Pistoletti, C, Iacono, ID, Patria, MF, Varin, E, Peroni, D, Comberiati, P, Chini, L, Moschese, V, Lucarelli, S, Bernardini, R, Pingitore, G, Pelosi, U, Olcese, R, Moretti, M, Cirisano, A, Faggian, D, Travaglini, A, Plebani, M, Verga, MC, Calvani, M, Giordani, P, Matricardi, PM, Ontiveros, N, Cabrera-Chavez, F, Galand, J, Beaudouin, E, Pineau, F, Sakai, S, Matsunaga, K, Teshima, R, Larré, C, Denery, S, Tschirner, S, Trendelenburg, V, Schulz, G, Niggemann, B, Beyer, K, Bouferkas, Y, Belabbas, Y, Saidi, D, Kheroua, O, Mecherfi, KEE, Guendouz, M, Haddi, A, Kaddouri, H, Amaral, L, Pereira, A, Rodrigues, S, Datema, M, Jongejan, L, Clausen, M, Knulst, A, Papadopoulos, N, Kowalski, M, de Blay, F, Zwinderman, A, Hoffman-Sommergruber, K, Ballmer-Weber, B, Fernandez-Rivas, M, Deng, S, Yin, J, Eisenmann, C, Nassiri, M, Reinert, R, van der Valk, JPM, van Wijk, RG, Vergouwe, Y, Steyerberg, EW, Reitsma, M, Wichers, HJ, Savelkoul, HFJ, Vlieg-Boerstra, B, Dubois, AEJ, Carolino, F, Rodolfo, A, Cernadas, J, Roa-Medellín, D, Rodriguez-Fernandez, A, Navarro, J, Albendiz, V, Baeza, ML, Intente-Herrero, S, Mikkelsen, A, Mehlig, K, Lissner, L, Verrill, L, Luccioli, S, van Bilsen, J, Kuper, F, Wolterbeek, A, Rankouhi, TR, Verschuren, L, Cnossen, H, Jeurink, P, Garssen, J, Knippels, L, Garthoff, J, Houben, G, Leeman, W, Eleonore Pettersson, M, Schins, AMM, Koppelman, GH, Kollen, BJ, Zubchenko, S, Kuntz, S, Mérida, P, Álvaro, M, Riggioni, C, Castellanos, JH, Jimenez, R, Cap, M, Drumez, E, Lejeune, S, Thumerelle, C, Mordacq, C, Nève, V, Ricò, S, Varini, M, Nocerino, R, Cosenza, L, Amoroso, A, Di Costanzo, M, Di Scala, C, Bedogni, G, Canani, RB, Turner, PJ, Poza-Guedes, P, González-Pérez, R, Sánchez-Machín, I, Matheu-Delgado, V, Wambre, E, Ballegaard, A-S, Madsen, C, Gregersen, J, Bøgh, KL, Aubert, P, Neunlist, M, Magnan, A, Lozano-Ojalvo, D, Pablos-Tanarro, A, Pérez-Rodríguez, L, Molina, E, López-Fandiño, R, Rekima, A, Macchiaverni, P, Turfkruyer, M, Holvoet, S, Dupuis, L, Baiz, N, Annesi-Maesano, I, Mercenier, A, Nutten, S, Verhasselt, V, Mrakovcic-Sutic, I, Banac, S, Sutic, I, Baricev-Novakovic, Z, Pavisic, V, Muñoz-Cano, R, Jiménez-Rodríguez, T, Corbacho, D, Roca-Ferrer, J, Bartra, J, Bulog, A, Micovic, V, Markiewicz, L, Szymkiewicz, A, Szyc, A, Wróblewska, B, Harvey, BM, Harthoorn, LF, Wesley Burks, A, Rentzos, G, Björk, A-LB, Bengtsson, U, Barber, C, Kalicinsky, C, Breynaert, C, Coorevits, L, Jansen, C, Van Hoeyveld, E, Verbeke, K, Kochuyt, A-M, Schrijvers, R, Deleanu, D, Muntean, A, Konstantakopoulou, M, Pasioti, M, Papadopoulou, A, Iliopoulou, A, Mikos, N, Kompoti, E, de Castro, ED, Bartalomé, B, Ue, KL, Griffiths, E, Till, S, Grimshaw, K, Roberts, G, Selby, A, Butiene, I, Larco, JI, Dubakiene, R, Fiandor, A, Fiocchi, A, Sigurdardottir, S, Sprikkelman, A, Schoemaker, A-F, Xepapadaki, P, Keil, T, Cojocariu, Z, Barbado, BS, Iancu, V, Arroabarren, E, Esarte, MG, Arteaga, M, Andrade, MC, Borges, D, Kalil, J, Bianchi, PG, Agondi, RC, Gupta, RK, Sharma, A, Gupta, K, Das, M, Dwivedi, P, Karseladze, R, Jorjoliani, L, Saginadze, L, Tskhakaia, M, Basello, K, Piuri, G, Speciani, AF, Speciani, MC, Camerotto, C, Zinno, F, Pakholchuk, O, Nedelska, S, Pattini, S, Costantino, MT, Peveri, S, Villalta, D, Savi, E, Costanzi, A, Revyakina, VA, Kiseleva, MA, Kuvshinova, ED, Larkova, IA, Shekhetov, AA, Silva, D, Moreira, A, Plácido, J, van der Kleij, H, van Twuijver, E, Sutorius, R, de Kam, P-J, van Odijk, J, Lindqvist, H, Lustig, E, Jácome, AAA, Aguilar, KLB, Domínguez, MG, Hernández, DAM, Caruso, C, Casale, C, Rapaccini, GL, Romano, A, De Vitis, I, Cocco, RR, Aranda, C, Mallozi, MC, Motta, JF, Moraes, L, Pastorino, A, Rosario, N, Goudouris, E, Porto, A, Wandalsen, NF, Sarinho, E, Sano, F, Solé, D, Pitsios, C, Petrodimopoulou, M, Papadopoulou, E, Passioti, M, Kontogianni, M, Adamia, N, Khaleva, E, del Prado, AP, Du Toit, G, Krzych, E, Samolinska-Zawisza, U, Furmanczyk, K, Tomaszewska, A, Raciborski, F, Lipiec, A, Samel-Kowalik, P, Walkiewicz, A, Borowicz, J, Samolinski, B, Nano, AL, Recto, M, Somoza, ML, López, NB, Alzate, DP, Ruano, FJ, Garcimartín, MI, Haroun, E, de la Torre, MV, Rojas, A, Onieva, ML, Canto, G, Rodrigues, A, Forno, A, Cabral, AJ, Gonçalves, R, Vorozhko, I, Sentsova, T, Chernyak, O, Denisova, S, Ilènko, L, Muhortnich, V, Zimmermann, C, Rohrbach, A, Bakhsh, FR, Boudewijn, K, Oomkes-Pilon, A-M, Van Ginkle, D, Šilar, M, Jeverica, A, Vesel, T, Avčin, T, Korošec, P, van der Valk, J, Berends, I, Arends, N, van Maaren, M, Wichers, H, Emons, J, Dubois, A, de Jong, N, Matsyura, O, Besh, L, Huang, C-H, Jan, T-R, Stiefel, G, Tratt, J, Kirk, K, Arasi, S, Caminiti, L, Crisafulli, G, Fiamingo, C, Fresta, J, Pajno, G, Remington, B, Kruizinga, A, Marty Blom, W, Westerhout, J, Bijlsma, S, Blankestijn, M, Otten, H, Klemans, R, Michelsen-Huisman, AD, van Os-Medendorp, H, Kruizinga, AG, Versluis, A, van Duijn, G, de Zeeuw-Brouwer, HM-L, Castenmiller, JJM, Noteborn, HPJM, Houben, GF, Bravin, K, Luyt, D, Javed, B, Couch, P, Munro, C, Padfield, P, Sperrin, M, Byrne, A, Oosthuizen, L, Kelleher, C, Ward, F, Brosnan, N, King, G, Corbet, E, Guzmán, JAH, García, MB, Asensio, O, Navarrete, LV, Larramona, H, Miró, XD, Pyrz, K, Austin, M, Boloh, Y, Galloway, D, Hernandez, P, Hourihane, JOB, Kenna, F, Majkowska-Wojciechowska, B, Regent, L, Themisb, M, Schnadt, S, Semic-Jusufagic, A, Galvin, AD, Kauppila, T, Kuitunen, M, Kitsioulis, NA, Douladiris, N, Kostoudi, S, Manolaraki, I, Mitsias, D, Manousakis, E, Papadopoulos, NG, Knibb, R, Hammond, J, Cooke, R, Yrjänä, J, Hanni, A-M, Vähäsarja, P, Mustonen, O, Dunder, T, Kulmala, P, Lasa, E, D’Amelio, C, Martínez, S, Joral, A, Gastaminza, G, Goikoetxea, MJ, Candy, DCA, Van Ampting, MTJ, Oude Nijhuis, MM, Butt, AM, Peroni, DG, Fox, AT, Knol, J, Michaelis, LJ, Padua, I, Padrao, P, Moreira, P, Barros, R, Sharif, H, Ahmed, M, Gomaa, N, Mens, J, Smit, K, Timmermans, F, Poredoš, T, Jeverica, AK, Sedmak, M, Benedik, E, Accetto, M, Zupančič, M, Yonamine, G, Soldateli, G, Aquilante, B, Pastorino, AC, de Moraes Beck, CL, Gushken, AK, de Barros Dorna, M, dos Santos, CN, Castro, APM, Al-Qahtani, A, Arnaout, R, Khaliq, AR, Amin, R, Sheikh, F, Alvarez, J, Anda, M, Palacios, M, De Prada, M, Ponce, C, Balbino, B, Sibilano, R, Marichal, T, Gaudenzio, N, Karasuyama, H, Bruhns, P, Tsai, M, Reber, LL, Galli, SJ, Ferreira, AR, Cernadas, JR, del Campo García, A, Fernández, SP, Carrera, NS, Sánchez-Cruz, FB, Lorenzo, JRF, Claus, S, Pföhler, C, Ruëff, F, Treudler, R, Jaume, ME, Madroñero, A, Perez, MTG, Julia, JC, Plovdiv, CH, Gethings, L, Langridge, J, Adel-Patient, K, Bernard, H, Barcievic-Jones, I, Sokolova, R, Yankova, R, Ivanovska, M, Murdjeva, M, Popova, T, Dermendzhiev, S, Karjalainen, M, Lehnigk, U, Brown, D, Locklear, JC, Locklear, J, Maris, I, Hourihane, J, Ornelas, C, Caiado, J, Ferreira, MB, Pereira-Barbosa, M, Puente, Y, Daza, JC, Monteseirin, FJ, Ukleja-Sokolowska, N, Gawronska-Ukleja, E, Zbikowska-Gotz, M, Bartuzi, Z, Sokolowski, L, Adams, A, Mahon, B, English, K, Gourdon-Dubois, N, Sellam, L, Pereira, B, Michaud, E, Messaoudi, K, Evrard, B, Fauquert, J-L, Palomares, F, Gomez, G, Rodriguez, MJ, Galindo, L, Molina, A, Paparo, L, Mennini, M, Aitoro, R, Wawrzeńczyk, A, Przybyszewski, M, Sarıcoban, HE, Ugras, M, Yalvac, Z, Flokstra-de Blok, BMJ, van der Velde, JL, Vereda, A, Ippolito, C, Traversa, A, Adriano, D, Bianchi, DM, Gallina, S, Decastelli, L, Makatsori, M, Miles, A, Devetak, SP, Devetak, I, Tabet, SA, Trandbohus, JF, Winther, P, Malling, H-J, Hansen, KS, Garvey, LH, Wang, C-C, Cheng, Y-H, Tung, C-W, Dietrich, M, Marenholz, I, Kalb, B, Grosche, S, Blümchen, K, Schlags, R, Price, M, Rietz, S, Esparza-Gordillo, J, Lau, S, Lee, Y-A, Almontasheri, A, Bahkali, MA, Elshorbagi, S, Alfhaid, A, Altamimi, M, Madbouly, E, Al-Dhekri, H, Arnaout, RK, Basagaña, M, Miquel, S, Bartolomé, B, Brix, B, Rohwer, S, Brandhoff, S, Berger, A, Suer, W, Weimann, A, Bueno, C, Martín-Pedraza, L, Abián, S, Segundo-Acosta, PS, López-Rodríguez, JC, Barderas, R, Batanero, E, Cuesta-Herranz, J, Villalba, MT, Correia, M, Benito-Garcia, F, Arêde, C, Piedade, S, Morais-Almeida, M, Hindley, J, Yarham, R, Kuklinska-Pijanka, A, Gillick, D, Patient, K, Chapman, MD, Miranda, A, Matos, E, Sokolova, A, Rao, H, Baricevic-Jones, I, Smith, F, Xue, W, Magnusdottir, H, Vidarsdottir, AG, Lund, S, Jensen, AB, Ludviksson, BR, Simon, R, Elfont, R, Bennett, S, Voyksner, R, de Lurdes Torre, M, Yürek, S, Faber, MA, Bastiaensen, A, Mangodt, E, van Gasse, A, Decuyper, I, Sabato, V, Hagendorens, MM, Bridts, CH, De Clerck, LS, Ebo, D, Schwarz, S, Ziegert, M, Albroscheit, S, Schwager, C, Kull, S, Behrends, J, Röckendorf, N, Schocker, F, Frey, A, Homann, A, Becker, W-M, Jappe, U, Zaabat, N, Osscini, S, Agabriel, C, Sterling, B, Carsin, A, Liabeuf, V, Maćków, M, Zbróg, A, Bronkowska, M, Courtois, J, Gadisseur, R, Bertholet, C, Lukas, P, Cavalier, E, Delahaut, P, Quinting, B, Gertmo, MB, Hasseus, ET, Barzylovych, V, Oliveira, J, Ensina, LF, Aranda, CS, Dopazo, L, Lopez, R, Perez, R, Santos-Diez, L, Bilbao, A, Garcia, JM, Núñez, IG, Mármol, MÁA, Villarejo, MJB, Martos, JAB, Vergara, MS, García, JMI, Michalska, A, Sergiejko, G, Zacniewski, R, Ghiordanescu, I-M, Deaconu, C, Popescu, M, Bumbacea, RS, Ibranji, A, Nikolla, E, Loloci, G, Juel-Berg, N, Larsen, LF, Poulsen, LK, Marcelino, J, Prata, R, Costa, AC, Duarte, F, Neto, M, Santos, J, Pestana, LC, Sampaio, D, Minale, P, Dignetti, P, Bignardi, D, Nedelea, I, Popescu, F-D, Vieru, M, Secureanu, F-A, Ganea, CS, Vieira, M, Silva, JPM, Watts, T, Watts, S, Lomikovska, M, Peredelskaya, M, Nenasheva, N, Filipovic, I, Zivkovic, Z, Filipovic, D, Higgs, J, Warner, A, Jones, C, Pouessel, G, Claverie, C, Labreuche, J, Renaudin, J-M, Dorkenoo, A, Eb, M, Moneret-Vautrin, A, Deschildre, A, Leteurtre, S, Grabenhenrich, L, Worm, M, Dölle, S, Scherer, K, Hutteger, I, Christensen, M, Bindslev-Jensen, C, Mortz, C, Eller, E, Kjaer, HF, Carneiro-Leão, L, Badas, J, Coimbra, A, Levy, DP, Ben-Shoshan, M, Rimon, A, Benor, S, Arends, NJT, Edelbroek, N, de Groot, H, Emons, JAM, Brand, HKA, Verhoeven, D, van Veen, LN, de Jong, NW, Noh, G, Jang, EH, Pascal, M, Dominguez, O, Piquer, M, Alvaro, M, Jimenez-Feijoo, R, Lozano, J, Machinena, A, del Mar Folqué, M, Giner, MT, Plaza, AM, Turner, P, Patel, N, Vazquez-Ortiz, M, Lindsley, S, Walker, L, Rosenberg, S, Mari, A, Alessandri, C, Giangrieco, I, Tuppo, L, Rafaiani, C, Mitterer, G, Ciancamerla, M, Ferrara, R, Bernardi, ML, Zennaro, D, Tamburrini, M, Ciardiello, MA, Harwanegg, C, Fernandez, A, Selb, R, Egenmann, P, Epstein, M, Hoffmann-Sommergruber, K, Koning, F, Lovik, M, Clare Mills, EN, Moreno, J, van Loveren, H, Wal, J-M, Diesner, S, Bergmayr, C, Pfitzner, B, Assmann, VE, Starkl, P, Endesfelder, D, Eiwegger, T, Szepfalusi, Z, Fehrenbach, H, Jensen-Jarolim, E, Hartmann, A, Pali-Schöll, I, Untersmayr, E, Wille, S, Meyer, P, Klingebiel, C, Lidholm, J, Ehrenberg, A, Östling, J, Cleach, I, Mège, J-L, Vitte, J, Aina, R, Dubiela, P, Pfeifer, S, Bublin, M, Radauer, C, Humeniuk, P, Kabasser, S, Asero, R, Bogas, G, Gomez, F, Campo, P, Salas, M, Doña, I, Barrionuevo, E, Guerrero, MA, Mayorga, C, Prieto, A, Barber, D, Torres, MJ, Jamin, A, Wangorsch, A, Ballmer, B, Vieths, S, Scheurer, S, Apostolovic, D, Mihailovic, J, Krstic, M, Starkhammar, M, Velickovic, TC, Hamsten, C, van Hage, M, van Erp, FC, Knol, EF, Kansen, HM, Pontoppidan, B, Meijer, Y, van der Ent, CK, Knulst, AC, Sayers, R, Brown, H, Custovic, A, Simpson, A, Mills, C, Schulz, J, Akkerdaas, J, Totis, M, Capt, A, Herouet-Guicheney, C, van Ree, R, Banerjee, T, Banerjee, A, Claude, M, Bouchaud, G, Lupi, R, Castan, L, Tranquet, O, Denery-Papini, S, Bodinier, M, Brossard, C, De Poi, R, Gritti, E, De Dominicis, E, Popping, B, de Laureto, PP, Palosuo, K, Kukkonen, AK, Pelkonen, A, Mäkelä, M, Lee, NA, Rost, J, Muralidharan, S, Campbell, D, Mehr, S, Nock, C, Baumert, J, Taylor, S, Mastrorilli, C, Tripodi, S, Caffarelli, C, Perna, S, Di Rienzo Businco, A, Sfika, I, Dondi, A, Bianchi, A, Dascola, CP, Ricci, G, Cipriani, F, Maiello, N, del Giudice, MM, Frediani, T, Frediani, S, Macrì, F, Pistoletti, C, Iacono, ID, Patria, MF, Varin, E, Peroni, D, Comberiati, P, Chini, L, Moschese, V, Lucarelli, S, Bernardini, R, Pingitore, G, Pelosi, U, Olcese, R, Moretti, M, Cirisano, A, Faggian, D, Travaglini, A, Plebani, M, Verga, MC, Calvani, M, Giordani, P, Matricardi, PM, Ontiveros, N, Cabrera-Chavez, F, Galand, J, Beaudouin, E, Pineau, F, Sakai, S, Matsunaga, K, Teshima, R, Larré, C, Denery, S, Tschirner, S, Trendelenburg, V, Schulz, G, Niggemann, B, Beyer, K, Bouferkas, Y, Belabbas, Y, Saidi, D, Kheroua, O, Mecherfi, KEE, Guendouz, M, Haddi, A, Kaddouri, H, Amaral, L, Pereira, A, Rodrigues, S, Datema, M, Jongejan, L, Clausen, M, Knulst, A, Papadopoulos, N, Kowalski, M, de Blay, F, Zwinderman, A, Hoffman-Sommergruber, K, Ballmer-Weber, B, Fernandez-Rivas, M, Deng, S, Yin, J, Eisenmann, C, Nassiri, M, Reinert, R, van der Valk, JPM, van Wijk, RG, Vergouwe, Y, Steyerberg, EW, Reitsma, M, Wichers, HJ, Savelkoul, HFJ, Vlieg-Boerstra, B, Dubois, AEJ, Carolino, F, Rodolfo, A, Cernadas, J, Roa-Medellín, D, Rodriguez-Fernandez, A, Navarro, J, Albendiz, V, Baeza, ML, Intente-Herrero, S, Mikkelsen, A, Mehlig, K, Lissner, L, Verrill, L, Luccioli, S, van Bilsen, J, Kuper, F, Wolterbeek, A, Rankouhi, TR, Verschuren, L, Cnossen, H, Jeurink, P, Garssen, J, Knippels, L, Garthoff, J, Houben, G, Leeman, W, Eleonore Pettersson, M, Schins, AMM, Koppelman, GH, Kollen, BJ, Zubchenko, S, Kuntz, S, Mérida, P, Álvaro, M, Riggioni, C, Castellanos, JH, Jimenez, R, Cap, M, Drumez, E, Lejeune, S, Thumerelle, C, Mordacq, C, Nève, V, Ricò, S, Varini, M, Nocerino, R, Cosenza, L, Amoroso, A, Di Costanzo, M, Di Scala, C, Bedogni, G, Canani, RB, Turner, PJ, Poza-Guedes, P, González-Pérez, R, Sánchez-Machín, I, Matheu-Delgado, V, Wambre, E, Ballegaard, A-S, Madsen, C, Gregersen, J, Bøgh, KL, Aubert, P, Neunlist, M, Magnan, A, Lozano-Ojalvo, D, Pablos-Tanarro, A, Pérez-Rodríguez, L, Molina, E, López-Fandiño, R, Rekima, A, Macchiaverni, P, Turfkruyer, M, Holvoet, S, Dupuis, L, Baiz, N, Annesi-Maesano, I, Mercenier, A, Nutten, S, Verhasselt, V, Mrakovcic-Sutic, I, Banac, S, Sutic, I, Baricev-Novakovic, Z, Pavisic, V, Muñoz-Cano, R, Jiménez-Rodríguez, T, Corbacho, D, Roca-Ferrer, J, Bartra, J, Bulog, A, Micovic, V, Markiewicz, L, Szymkiewicz, A, Szyc, A, Wróblewska, B, Harvey, BM, Harthoorn, LF, Wesley Burks, A, Rentzos, G, Björk, A-LB, Bengtsson, U, Barber, C, Kalicinsky, C, Breynaert, C, Coorevits, L, Jansen, C, Van Hoeyveld, E, Verbeke, K, Kochuyt, A-M, Schrijvers, R, Deleanu, D, Muntean, A, Konstantakopoulou, M, Pasioti, M, Papadopoulou, A, Iliopoulou, A, Mikos, N, Kompoti, E, de Castro, ED, Bartalomé, B, Ue, KL, Griffiths, E, Till, S, Grimshaw, K, Roberts, G, Selby, A, Butiene, I, Larco, JI, Dubakiene, R, Fiandor, A, Fiocchi, A, Sigurdardottir, S, Sprikkelman, A, Schoemaker, A-F, Xepapadaki, P, Keil, T, Cojocariu, Z, Barbado, BS, Iancu, V, Arroabarren, E, Esarte, MG, Arteaga, M, Andrade, MC, Borges, D, Kalil, J, Bianchi, PG, Agondi, RC, Gupta, RK, Sharma, A, Gupta, K, Das, M, Dwivedi, P, Karseladze, R, Jorjoliani, L, Saginadze, L, Tskhakaia, M, Basello, K, Piuri, G, Speciani, AF, Speciani, MC, Camerotto, C, Zinno, F, Pakholchuk, O, Nedelska, S, Pattini, S, Costantino, MT, Peveri, S, Villalta, D, Savi, E, Costanzi, A, Revyakina, VA, Kiseleva, MA, Kuvshinova, ED, Larkova, IA, Shekhetov, AA, Silva, D, Moreira, A, Plácido, J, van der Kleij, H, van Twuijver, E, Sutorius, R, de Kam, P-J, van Odijk, J, Lindqvist, H, Lustig, E, Jácome, AAA, Aguilar, KLB, Domínguez, MG, Hernández, DAM, Caruso, C, Casale, C, Rapaccini, GL, Romano, A, De Vitis, I, Cocco, RR, Aranda, C, Mallozi, MC, Motta, JF, Moraes, L, Pastorino, A, Rosario, N, Goudouris, E, Porto, A, Wandalsen, NF, Sarinho, E, Sano, F, Solé, D, Pitsios, C, Petrodimopoulou, M, Papadopoulou, E, Passioti, M, Kontogianni, M, Adamia, N, Khaleva, E, del Prado, AP, Du Toit, G, Krzych, E, Samolinska-Zawisza, U, Furmanczyk, K, Tomaszewska, A, Raciborski, F, Lipiec, A, Samel-Kowalik, P, Walkiewicz, A, Borowicz, J, Samolinski, B, Nano, AL, Recto, M, Somoza, ML, López, NB, Alzate, DP, Ruano, FJ, Garcimartín, MI, Haroun, E, de la Torre, MV, Rojas, A, Onieva, ML, Canto, G, Rodrigues, A, Forno, A, Cabral, AJ, Gonçalves, R, Vorozhko, I, Sentsova, T, Chernyak, O, Denisova, S, Ilènko, L, Muhortnich, V, Zimmermann, C, Rohrbach, A, Bakhsh, FR, Boudewijn, K, Oomkes-Pilon, A-M, Van Ginkle, D, Šilar, M, Jeverica, A, Vesel, T, Avčin, T, Korošec, P, van der Valk, J, Berends, I, Arends, N, van Maaren, M, Wichers, H, Emons, J, Dubois, A, de Jong, N, Matsyura, O, Besh, L, Huang, C-H, Jan, T-R, Stiefel, G, Tratt, J, Kirk, K, Arasi, S, Caminiti, L, Crisafulli, G, Fiamingo, C, Fresta, J, Pajno, G, Remington, B, Kruizinga, A, Marty Blom, W, Westerhout, J, Bijlsma, S, Blankestijn, M, Otten, H, Klemans, R, Michelsen-Huisman, AD, van Os-Medendorp, H, Kruizinga, AG, Versluis, A, van Duijn, G, de Zeeuw-Brouwer, HM-L, Castenmiller, JJM, Noteborn, HPJM, Houben, GF, Bravin, K, Luyt, D, Javed, B, Couch, P, Munro, C, Padfield, P, Sperrin, M, Byrne, A, Oosthuizen, L, Kelleher, C, Ward, F, Brosnan, N, King, G, Corbet, E, Guzmán, JAH, García, MB, Asensio, O, Navarrete, LV, Larramona, H, Miró, XD, Pyrz, K, Austin, M, Boloh, Y, Galloway, D, Hernandez, P, Hourihane, JOB, Kenna, F, Majkowska-Wojciechowska, B, Regent, L, Themisb, M, Schnadt, S, Semic-Jusufagic, A, Galvin, AD, Kauppila, T, Kuitunen, M, Kitsioulis, NA, Douladiris, N, Kostoudi, S, Manolaraki, I, Mitsias, D, Manousakis, E, Papadopoulos, NG, Knibb, R, Hammond, J, Cooke, R, Yrjänä, J, Hanni, A-M, Vähäsarja, P, Mustonen, O, Dunder, T, Kulmala, P, Lasa, E, D’Amelio, C, Martínez, S, Joral, A, Gastaminza, G, Goikoetxea, MJ, Candy, DCA, Van Ampting, MTJ, Oude Nijhuis, MM, Butt, AM, Peroni, DG, Fox, AT, Knol, J, Michaelis, LJ, Padua, I, Padrao, P, Moreira, P, Barros, R, Sharif, H, Ahmed, M, Gomaa, N, Mens, J, Smit, K, Timmermans, F, Poredoš, T, Jeverica, AK, Sedmak, M, Benedik, E, Accetto, M, Zupančič, M, Yonamine, G, Soldateli, G, Aquilante, B, Pastorino, AC, de Moraes Beck, CL, Gushken, AK, de Barros Dorna, M, dos Santos, CN, Castro, APM, Al-Qahtani, A, Arnaout, R, Khaliq, AR, Amin, R, Sheikh, F, Alvarez, J, Anda, M, Palacios, M, De Prada, M, Ponce, C, Balbino, B, Sibilano, R, Marichal, T, Gaudenzio, N, Karasuyama, H, Bruhns, P, Tsai, M, Reber, LL, Galli, SJ, Ferreira, AR, Cernadas, JR, del Campo García, A, Fernández, SP, Carrera, NS, Sánchez-Cruz, FB, Lorenzo, JRF, Claus, S, Pföhler, C, Ruëff, F, Treudler, R, Jaume, ME, Madroñero, A, Perez, MTG, Julia, JC, Plovdiv, CH, Gethings, L, Langridge, J, Adel-Patient, K, Bernard, H, Barcievic-Jones, I, Sokolova, R, Yankova, R, Ivanovska, M, Murdjeva, M, Popova, T, Dermendzhiev, S, Karjalainen, M, Lehnigk, U, Brown, D, Locklear, JC, Locklear, J, Maris, I, Hourihane, J, Ornelas, C, Caiado, J, Ferreira, MB, Pereira-Barbosa, M, Puente, Y, Daza, JC, Monteseirin, FJ, Ukleja-Sokolowska, N, Gawronska-Ukleja, E, Zbikowska-Gotz, M, Bartuzi, Z, Sokolowski, L, Adams, A, Mahon, B, English, K, Gourdon-Dubois, N, Sellam, L, Pereira, B, Michaud, E, Messaoudi, K, Evrard, B, Fauquert, J-L, Palomares, F, Gomez, G, Rodriguez, MJ, Galindo, L, Molina, A, Paparo, L, Mennini, M, Aitoro, R, Wawrzeńczyk, A, Przybyszewski, M, Sarıcoban, HE, Ugras, M, Yalvac, Z, Flokstra-de Blok, BMJ, van der Velde, JL, Vereda, A, Ippolito, C, Traversa, A, Adriano, D, Bianchi, DM, Gallina, S, Decastelli, L, Makatsori, M, Miles, A, Devetak, SP, Devetak, I, Tabet, SA, Trandbohus, JF, Winther, P, Malling, H-J, Hansen, KS, Garvey, LH, Wang, C-C, Cheng, Y-H, Tung, C-W, Dietrich, M, Marenholz, I, Kalb, B, Grosche, S, Blümchen, K, Schlags, R, Price, M, Rietz, S, Esparza-Gordillo, J, Lau, S, Lee, Y-A, Almontasheri, A, Bahkali, MA, Elshorbagi, S, Alfhaid, A, Altamimi, M, Madbouly, E, Al-Dhekri, H, Arnaout, RK, Basagaña, M, Miquel, S, Bartolomé, B, Brix, B, Rohwer, S, Brandhoff, S, Berger, A, Suer, W, Weimann, A, Bueno, C, Martín-Pedraza, L, Abián, S, Segundo-Acosta, PS, López-Rodríguez, JC, Barderas, R, Batanero, E, Cuesta-Herranz, J, Villalba, MT, Correia, M, Benito-Garcia, F, Arêde, C, Piedade, S, Morais-Almeida, M, Hindley, J, Yarham, R, Kuklinska-Pijanka, A, Gillick, D, Patient, K, Chapman, MD, Miranda, A, Matos, E, Sokolova, A, Rao, H, Baricevic-Jones, I, Smith, F, Xue, W, Magnusdottir, H, Vidarsdottir, AG, Lund, S, Jensen, AB, Ludviksson, BR, Simon, R, Elfont, R, Bennett, S, Voyksner, R, de Lurdes Torre, M, Yürek, S, Faber, MA, Bastiaensen, A, Mangodt, E, van Gasse, A, Decuyper, I, Sabato, V, Hagendorens, MM, Bridts, CH, De Clerck, LS, Ebo, D, Schwarz, S, Ziegert, M, Albroscheit, S, Schwager, C, Kull, S, Behrends, J, Röckendorf, N, Schocker, F, Frey, A, Homann, A, Becker, W-M, Jappe, U, Zaabat, N, Osscini, S, Agabriel, C, Sterling, B, Carsin, A, Liabeuf, V, Maćków, M, Zbróg, A, Bronkowska, M, Courtois, J, Gadisseur, R, Bertholet, C, Lukas, P, Cavalier, E, Delahaut, P, Quinting, B, Gertmo, MB, Hasseus, ET, Barzylovych, V, Oliveira, J, Ensina, LF, Aranda, CS, Dopazo, L, Lopez, R, Perez, R, Santos-Diez, L, Bilbao, A, Garcia, JM, Núñez, IG, Mármol, MÁA, Villarejo, MJB, Martos, JAB, Vergara, MS, García, JMI, Michalska, A, Sergiejko, G, Zacniewski, R, Ghiordanescu, I-M, Deaconu, C, Popescu, M, Bumbacea, RS, Ibranji, A, Nikolla, E, Loloci, G, Juel-Berg, N, Larsen, LF, Poulsen, LK, Marcelino, J, Prata, R, Costa, AC, Duarte, F, Neto, M, Santos, J, Pestana, LC, Sampaio, D, Minale, P, Dignetti, P, Bignardi, D, Nedelea, I, Popescu, F-D, Vieru, M, Secureanu, F-A, Ganea, CS, Vieira, M, Silva, JPM, Watts, T, Watts, S, Lomikovska, M, Peredelskaya, M, Nenasheva, N, Filipovic, I, Zivkovic, Z, Filipovic, D, Higgs, J, Warner, A, and Jones, C
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- 2017
28. A new framework for the documentation and interpretation of oral food challenges in population-based and clinical research
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Grabenhenrich, L B, Reich, A, Bellach, J, Trendelenburg, V, Sprikkelman, A B, Roberts, G, Grimshaw, K E C; https://orcid.org/0000-0003-3649-7963, Sigurdardottir, S, Kowalski, M L, Papadopoulos, N G, Quirce, S, Dubakiene, R, Niggemann, B, Fernández-Rivas, M, Ballmer-Weber, B, van Ree, R, Schnadt, S, Mills, E N C, Keil, T, Beyer, K, Grabenhenrich, L B, Reich, A, Bellach, J, Trendelenburg, V, Sprikkelman, A B, Roberts, G, Grimshaw, K E C; https://orcid.org/0000-0003-3649-7963, Sigurdardottir, S, Kowalski, M L, Papadopoulos, N G, Quirce, S, Dubakiene, R, Niggemann, B, Fernández-Rivas, M, Ballmer-Weber, B, van Ree, R, Schnadt, S, Mills, E N C, Keil, T, and Beyer, K
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- 2017
29. Incidence and natural history of challenge-proven cow's milk allergy in European children - EuroPrevall birth cohort
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Schoemaker, A.A. Sprikkelman, A.B. Grimshaw, K.E. Roberts, G. Grabenhenrich, L. Rosenfeld, L. Siegert, S. Dubakiene, R. Rudzeviciene, O. Reche, M. Fiandor, A. Papadopoulos, N.G. Malamitsi-Puchner, A. Fiocchi, A. Dahdah, L. Sigurdardottir, S.T. Clausen, M. Stańczyk-Przyłuska, A. Zeman, K. Mills, E.N.C. McBride, D. Keil, T. Beyer, K.
- Subjects
humanities - Abstract
Background Cow's milk allergy (CMA) is one of the most commonly reported childhood food problems. Community-based incidence and prevalence estimates vary widely, due to possible misinterpretations of presumed reactions to milk and differences in study design, particularly diagnostic criteria. Methods Children from the EuroPrevall birth cohort in 9 European countries with symptoms possibly related to CMA were invited for clinical evaluation including cows' milk-specific IgE antibodies (IgE), skin prick test (SPT) reactivity and double-blind, placebo-controlled food challenge. Results Across Europe, 12 049 children were enrolled, and 9336 (77.5%) were followed up to 2 years of age. CMA was suspected in 358 children and confirmed in 55 resulting in an overall incidence of challenge-proven CMA of 0.54% (95% CI 0.41-0.70). National incidences ranged from 1% (in the Netherlands and UK) to
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- 2015
30. Incidence and natural history of hen's egg allergy in the first 2 years of life - The EuroPrevall birth cohort study
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Xepapadaki, P. Fiocchi, A. Grabenhenrich, L. Roberts, G. Grimshaw, K.E.C. Fiandor, A. Larco, J.I. Sigurdardottir, S. Clausen, M. Papadopoulos, N.G. Dahdah, L. Mackie, A. Sprikkelman, A.B. Schoemaker, A.A. Dubakiene, R. Butiene, I. Kowalski, M.L. Zeman, K. Gavrili, S. Keil, T. Beyer, K. and Xepapadaki, P. Fiocchi, A. Grabenhenrich, L. Roberts, G. Grimshaw, K.E.C. Fiandor, A. Larco, J.I. Sigurdardottir, S. Clausen, M. Papadopoulos, N.G. Dahdah, L. Mackie, A. Sprikkelman, A.B. Schoemaker, A.A. Dubakiene, R. Butiene, I. Kowalski, M.L. Zeman, K. Gavrili, S. Keil, T. Beyer, K.
- Abstract
Background Parents and health staff perceive hen's egg allergy (HEA) as a common food allergy in early childhood, but the true incidence is unclear because population-based studies with gold-standard diagnostic criteria are lacking. Objective To establish the incidence and course of challenge-confirmed HEA in children, from birth until the age of 24 months, in different European regions. Methods In the EuroPrevall birth cohort study, children with a suspected HEA and their age-matched controls were evaluated in 9 countries, using a standardized protocol including measurement of HE-specific immunoglobulin E-antibodies in serum, skin prick tests, and double-blind, placebo-controlled food challenges (DBPCFC). Results Across Europe, 12 049 newborns were enrolled, and 9336 (77.5%) were followed up to 2 years of age. In 298 children, HEA was suspected and DBPCFC was offered. HEA by age two was confirmed in 86 of 172 challenged children (mean raw incidence 0.84%, 95% confidence interval (95% CI) 0.67-1.03). Adjusted mean incidence of HEA was 1.23% (95% CI 0.98-1.51) considering possible cases among eligible children who were not challenged. Centre-specific incidence ranged from United Kingdom (2.18%, 95% CI 1.27-3.47) to Greece (0.07%). Half of the HE-allergic children became tolerant to HE within 1 year after the initial diagnosis. Conclusions The largest multinational European birth cohort study on food allergy with gold-standard diagnostic methods showed that the mean adjusted incidence of HEA was considerably lower than previously documented, although differences in incidence rates among countries were noted. Half of the children with documented HEA gained tolerance within 1 year postdiagnosis. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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- 2016
31. Can we identify patients at risk of life-threatening allergic reactions to food?
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Turner, P. J., Baumert, J. L., Beyer, K., Boyle, R. J., Chan, C. H., Clark, A. T., Crevel, R. W.R., DunnGalvin, A., Fernández-Rivas, M., Gowland, M. H., Grabenhenrich, L., Hardy, S., Houben, G. F., O'B Hourihane, J., Muraro, A., Poulsen, L. K., Pyrz, K., Remington, B. C., Schnadt, S., van Ree, R., Venter, C., Worm, M., Mills, E. N.C., Roberts, G., Ballmer-Weber, B. K., Turner, P. J., Baumert, J. L., Beyer, K., Boyle, R. J., Chan, C. H., Clark, A. T., Crevel, R. W.R., DunnGalvin, A., Fernández-Rivas, M., Gowland, M. H., Grabenhenrich, L., Hardy, S., Houben, G. F., O'B Hourihane, J., Muraro, A., Poulsen, L. K., Pyrz, K., Remington, B. C., Schnadt, S., van Ree, R., Venter, C., Worm, M., Mills, E. N.C., Roberts, G., and Ballmer-Weber, B. K.
- Abstract
Anaphylaxis has been defined as a ‘severe, life-threatening generalized or systemic hypersensitivity reaction’. However, data indicate that the vast majority of food-triggered anaphylactic reactions are not life-threatening. Nonetheless, severe life-threatening reactions do occur and are unpredictable. We discuss the concepts surrounding perceptions of severe, life-threatening allergic reactions to food by different stakeholders, with particular reference to the inclusion of clinical severity as a factor in allergy and allergen risk management. We review the evidence regarding factors that might be used to identify those at most risk of severe allergic reactions to food, and the consequences of misinformation in this regard. For example, a significant proportion of food-allergic children also have asthma, yet almost none will experience a fatal food-allergic reaction; asthma is not, in itself, a strong predictor for fatal anaphylaxis. The relationship between dose of allergen exposure and symptom severity is unclear. While dose appears to be a risk factor in at least a subgroup of patients, studies report that individuals with prior anaphylaxis do not have a lower eliciting dose than those reporting previous mild reactions. It is therefore important to consider severity and sensitivity as separate factors, as a highly sensitive individual will not necessarily experience severe symptoms during an allergic reaction. We identify the knowledge gaps that need to be addressed to improve our ability to better identify those most at risk of severe food-induced allergic reactions.
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- 2016
32. A new framework for the documentation and interpretation of oral food challenges in population-based and clinical research
- Author
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Grabenhenrich, L. B., primary, Reich, A., additional, Bellach, J., additional, Trendelenburg, V., additional, Sprikkelman, A. B., additional, Roberts, G., additional, Grimshaw, K. E. C., additional, Sigurdardottir, S., additional, Kowalski, M. L., additional, Papadopoulos, N. G., additional, Quirce, S., additional, Dubakiene, R., additional, Niggemann, B., additional, Fernández-Rivas, M., additional, Ballmer-Weber, B., additional, van Ree, R., additional, Schnadt, S., additional, Mills, E. N. C., additional, Keil, T., additional, and Beyer, K., additional
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- 2016
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33. Can we identify patients at risk of life-threatening allergic reactions to food?
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Turner, P. J., primary, Baumert, J. L., additional, Beyer, K., additional, Boyle, R. J., additional, Chan, C.-H., additional, Clark, A. T., additional, Crevel, R. W. R., additional, DunnGalvin, A., additional, Fernández-Rivas, M., additional, Gowland, M. H., additional, Grabenhenrich, L., additional, Hardy, S., additional, Houben, G. F., additional, O'B Hourihane, J., additional, Muraro, A., additional, Poulsen, L. K., additional, Pyrz, K., additional, Remington, B. C., additional, Schnadt, S., additional, van Ree, R., additional, Venter, C., additional, Worm, M., additional, Mills, E. N. C., additional, Roberts, G., additional, and Ballmer-Weber, B. K., additional
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- 2016
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34. The EuroPrevall birth cohort study on food allergy: Baseline characteristics of 12,000 newborns and their families from nine European countries
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Mcbride, D. Keil, T. Grabenhenrich, L. Dubakiene, R. Drasutiene, G. Fiocchi, A. Dahdah, L. Sprikkelman, A.B. Schoemaker, A.A. Roberts, G. Grimshaw, K. Kowalski, M.L. Stanczyk-Przyluska, A. Sigurdardottir, S. Clausen, M. Papadopoulos, N.G. Mitsias, D. Rosenfeld, L. Reche, M. Pascual, C. Reich, A. Hourihane, J. Wahn, U. Mills, E.N.C. Mackie, A. Beyer, K.
- Abstract
It is unclear why some children develop food allergy. The EuroPrevall birth cohort was established to examine regional differences in the prevalence and risk factors of food allergy in European children using gold-standard diagnostic criteria. The aim of this report was to describe pre-, post-natal and environmental characteristics among the participating countries. In nine countries across four major European climatic regions, mothers and their newborns were enrolled from October 2005 through February 2010. Using standardized questionnaires, we assessed allergic diseases and self-reported food hypersensitivity of parents and siblings, nutrition during pregnancy, nutritional supplements, medications, mode of delivery, socio-demographic data and home environmental exposures. A total of 12,049 babies and their families were recruited. Self-reported adverse reactions to food ever were considerably more common in mothers from Germany (30%), Iceland, United Kingdom, and the Netherlands (all 20-22%) compared with those from Italy (11%), Lithuania, Greece, Poland, and Spain (all 5-8%). Prevalence estimates of parental asthma, allergic rhinitis and eczema were highest in north-west (Iceland, UK), followed by west (Germany, the Netherlands), south (Greece, Italy, Spain) and lowest in central and east Europe (Poland, Lithuania). Over 17% of Spanish and Greek children were exposed to tobacco smoke in utero compared with only 8-11% in other countries. Caesarean section rate was highest in Greece (44%) and lowest in Spain (
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- 2012
35. Incidence and natural history of hen's egg allergy in the first 2 years of life-the EuroPrevall birth cohort study
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Xepapadaki, P., primary, Fiocchi, A., additional, Grabenhenrich, L., additional, Roberts, G., additional, Grimshaw, K. E. C., additional, Fiandor, A., additional, Larco, J. I., additional, Sigurdardottir, S., additional, Clausen, M., additional, Papadopoulos, N. G., additional, Dahdah, L., additional, Mackie, A., additional, Sprikkelman, A. B., additional, Schoemaker, A. A., additional, Dubakiene, R., additional, Butiene, I., additional, Kowalski, M. L., additional, Zeman, K., additional, Gavrili, S., additional, Keil, T., additional, and Beyer, K., additional
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- 2015
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36. Non‐IgE mediated cow's milk allergy in EuroPrevall
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Koletzko, S., primary, Heine, R. G., additional, Grimshaw, K. E., additional, Beyer, K., additional, Grabenhenrich, L., additional, Keil, T., additional, Sprikkelman, A. B., additional, and Roberts, G., additional
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- 2015
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37. Predictive values of component-specific IgE for the outcome of peanut and hazelnut food challenges in children
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Beyer, K., primary, Grabenhenrich, L., additional, Härtl, M., additional, Beder, A., additional, Kalb, B., additional, Ziegert, M., additional, Finger, A., additional, Harandi, N., additional, Schlags, R., additional, Gappa, M., additional, Puzzo, L., additional, Röblitz, H., additional, Millner-Uhlemann, M., additional, Büsing, S., additional, Ott, H., additional, Lange, L., additional, and Niggemann, B., additional
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- 2014
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38. Transcutaneous Bilirubin After Phototherapy in Term and Preterm Infants
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Grabenhenrich, J., primary, Grabenhenrich, L., additional, Buhrer, C., additional, and Berns, M., additional
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- 2014
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39. Higher glucose levels associated with lower memory and reduced hippocampal microstructure
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Grabenhenrich, L. B., primary, Roll, S., additional, Kerti, L., additional, Witte, A. V., additional, Grittner, U., additional, and Floeel, A., additional
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- 2014
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40. Elicitors and cofactors of food-induced anaphylaxis
- Author
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Hompes, S, primary, Grabenhenrich, L, additional, Grünhagen, J, additional, Dölle, S, additional, and Worm, M, additional
- Published
- 2013
- Full Text
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41. Klinische Epidemiologie der Anaphylaxie
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Worm, M., primary, Eckermann, O., additional, Hompes, S., additional, and Grabenhenrich, L., additional
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- 2012
- Full Text
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42. The EuroPrevall birth cohort study on food allergy: baseline characteristics of 12,000 newborns and their families from nine European countries
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McBride, D., primary, Keil, T., additional, Grabenhenrich, L., additional, Dubakiene, R., additional, Drasutiene, G., additional, Fiocchi, A., additional, Dahdah, L., additional, Sprikkelman, A. B., additional, Schoemaker, A. A., additional, Roberts, G., additional, Grimshaw, K., additional, Kowalski, M. L., additional, Stanczyk-Przyluska, A., additional, Sigurdardottir, S., additional, Clausen, M., additional, Papadopoulos, N. G., additional, Mitsias, D., additional, Rosenfeld, L., additional, Reche, M., additional, Pascual, C., additional, Reich, A., additional, Hourihane, J., additional, Wahn, U., additional, Mills, E. N. C., additional, Mackie, A., additional, and Beyer, K., additional
- Published
- 2011
- Full Text
- View/download PDF
43. Vergleich von Umwelt- und Lebensstilfaktoren allergischer und nicht allergischer Eltern: Ergebnisse der Basiserhebung der deutschen Teilnehmer der EuroPrevall-Geburtskohorte
- Author
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Grabenhenrich, L, primary, McBride, D, additional, Rosenfeld, L, additional, Reich, A, additional, Willich, S, additional, Wahn, U, additional, Beyer, K, additional, and Keil, T, additional
- Published
- 2010
- Full Text
- View/download PDF
44. Prävalenz von Nahrungsmittelallergien bei Kleinkindern bestimmt durch doppel-blinde plazebo-kontrollierte Provokationstests: Erste Ergebnisse für Deutschland aus der EuroPrevall Geburtskohortenstudie
- Author
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Keil, T, primary, McBride, D, additional, Rosenfeld, L, additional, Grabenhenrich, L, additional, Reich, A, additional, Willich, S, additional, Wahn, U, additional, and Beyer, K, additional
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- 2010
- Full Text
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45. Predictive values of component-specific Ig E for the outcome of peanut and hazelnut food challenges in children.
- Author
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Beyer, K., Grabenhenrich, L., Härtl, M., Beder, A., Kalb, B., Ziegert, M., Finger, A., Harandi, N., Schlags, R., Gappa, M., Puzzo, L., Röblitz, H., Millner‐Uhlemann, M., Büsing, S., Ott, H., Lange, L., and Niggemann, B.
- Subjects
- *
DIAGNOSIS of food allergies , *HAZELNUTS , *PHYSIOLOGICAL aspects of food habits , *QUALITY of life - Abstract
Background Oral challenges are the gold standard in food allergy diagnostic, but time-consuming. Aim of the study was to investigate the role of peanut- and hazelnut-component-specific Ig E in the diagnostics of peanut and hazelnut allergy and to identify cutoff levels to make some challenges superfluous. Methods In a prospective and multicenter study, children with suspected peanut or hazelnut allergy underwent oral challenges. Specific Ig E to peanut, hazelnut, and their components ( Ara h 1, Ara h 2, Ara h 3, and Ara h 8, Cor a 1, Cor a 8, Cor a 9, and Cor a 14) were determined by Immuno CAP- FEIA. Results A total of 210 children were challenged orally with peanut and 143 with hazelnut. 43% of the patients had a positive peanut and 31% a positive hazelnut challenge. With an area under the curve of 0.92 and 0.89, respectively, Ara h 2 and Cor a 14-specific Ig E discriminated between allergic and tolerant children better than peanut- or hazelnut-specific Ig E. For the first time, probability curves for peanut and hazelnut components have been calculated. A 90% probability for a positive peanut or hazelnut challenge was estimated for Ara h 2-specific Ig E at 14.4 kU/l and for Cor a 14-specific Ig E at 47.8 kU/l. A 95% probability could only be estimated for Ara h 2 at 42.2 kU/l. Conclusions Ara h 2- and Cor a 14-specific Ig E are useful to estimate the probability for a positive challenge outcome in the diagnostic work-up of peanut or hazelnut allergy making some food challenges superfluous. [ABSTRACT FROM AUTHOR]
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- 2015
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46. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
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Pouessel G, Claverie C, Labreuche J, Renaudin J, Dorkenoo A, Eb M, Moneret-Vautrin A, Deschildre A, Leteurtre S, Grabenhenrich L, Worm M, Dölle S, and Jones C
47. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
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Pouessel G, Claverie C, Labreuche J, Renaudin J, Dorkenoo A, Eb M, Moneret-Vautrin A, Deschildre A, Leteurtre S, Grabenhenrich L, Worm M, Dölle S, and Jones C
48. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
- Author
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Pouessel G, Claverie C, Labreuche J, Renaudin J, Dorkenoo A, Eb M, Moneret-Vautrin A, Deschildre A, Leteurtre S, Grabenhenrich L, Worm M, Dölle S, Scherer K, Hutteger I, Christensen M, Bindslev-Jensen C, Mortz C, Eller E, Hf, Kjaer, and Jones C
49. Reply.
- Author
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Grimshaw, K. E., Beyer, K., Grabenhenrich, L., Keil, T., Sprikkelman, A. B., and Roberts, G.
- Published
- 2015
50. Assessing the impact of Delta and Omicron in German intensive care units: a retrospective, nationwide multistate analysis.
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Lottes M, Grodd M, Grabenhenrich L, and Wolkewitz M
- Subjects
- Humans, Germany epidemiology, Retrospective Studies, Male, Female, Middle Aged, Aged, Adult, Aged, 80 and over, Patient Transfer statistics & numerical data, COVID-19 epidemiology, COVID-19 mortality, Intensive Care Units statistics & numerical data, SARS-CoV-2
- Abstract
Background: The spread of several severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) variants of concern (VOCs) has repeatedly led to increasing numbers of coronavirus disease 2019 (COVID-19) patients in German intensive care units (ICUs), resulting in capacity shortages and even transfers of COVID-19 intensive care patients between federal states in late 2021. In this respect, there is scarce evidence on the impact of predominant VOCs in German ICUs at the population level., Methods: A retrospective cohort study was conducted from July 01, 2021, to May 31, 2022, using daily nationwide inpatient billing data from German hospitals on COVID-19 intensive care patients and SARS-CoV-2 sequence data from Germany. A multivariable Poisson regression analysis was performed to estimate the incidence rate ratios (IRRs) of transfer (to another hospital during inpatient care), discharge (alive) and death of COVID-19 intensive care patients associated with Delta or Omicron, adjusted for age group and sex. In addition, a multistate approach was used for the clinical trajectories of COVID-19 intensive care patients to estimate their competing risk of transfer, discharge or death associated with Delta or Omicron, specifically concerning patient age., Results: A total of 6046 transfers, 33256 discharges, and 12114 deaths were included. Poisson regression analysis comparing Omicron versus Delta yielded an estimated adjusted IRR of 1.23 (95% CI 1.16-1.30) for transfers, 2.27 (95% CI 2.20-2.34) for discharges and 0.98 (95% CI 0.94-1.02) for deaths. For ICU deaths in particular, the estimated adjusted IRR increased from 0.14 (95% CI 0.08-0.22) for the 0-9 age group to 4.09 (95% CI 3.74-4.47) for those aged 90 and older compared to the reference group of 60-69-year-olds. Multistate analysis revealed that Omicron was associated with a higher estimated risk of discharge for COVID-19 intensive care patients across all ages, while Delta infection was associated with a higher estimated risk of transfer and death., Conclusions: Retrospective, nationwide comparisons of transfers, discharges and deaths of COVID-19 intensive care patients during Delta- and Omicron-dominated periods in Germany suggested overall less severe clinical trajectories associated with Omicron. Age was confirmed to be an important determinant of fatal clinical outcomes in COVID-19 intensive care patients, necessitating close therapeutic care for elderly people and appropriate public health control measures., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
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