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1. Interobserver reproducibility of cervical histology interpretation with and without p16 immunohistochemistry.

Author

Tao, Amy S, Zuna, Rosemary, Darragh, Teresa M, Grabe, Niels, Lahrmann, Bernd, Clarke, Megan A, and Wentzensen, Nicolas

Subjects
CERVICAL intraepithelial neoplasia, HUMAN papillomavirus, CERVICAL cancer, PATHOLOGISTS, PRECANCEROUS conditions
Abstract

Objectives Histopathological diagnosis of colposcopically identified cervical lesions is a critical step for the recognition of cervical cancer precursors requiring treatment. Although there have been efforts to standardize the histologic diagnosis of cervical biopsy specimens, in terms of terminology and use of biomarkers, there is no uniform approach in the pathology community. Adjunctive p16 immunohistochemistry (IHC) can highlight precancer diagnoses, with use recommendations outlined by the Lower Anogenital Squamous Terminology project. Methods We assessed the diagnostic reproducibility of cervical histopathological biopsy specimens with and without p16 staining among 2 expert pathologists. Results Interpretation of p16 IHC as positive vs negative was highly reproducible (92.5% agreement, κ = 0.85); greater variation was seen in the choice of which biopsy specimens required adjunctive p16 staining (78.0% agreement, κ = 0.43). Adjunctive p16 IHC did not significantly increase diagnostic agreement under multitiered grading systems (benign vs cervical intraepithelial neoplasia [CIN] 1/low-grade squamous intraepithelial lesion vs atypical squamous metaplasia vs CIN2/high-grade squamous intraepithelial lesion [HSIL] vs CIN3/HSIL-CIN3 vs cancer) (65.5% agreement, κ = 0.56 without p16; 70.0% agreement, κ = 0.58 with p16). However, when dichotomizing diagnoses based on clinical management (less than HSIL vs HSIL+), diagnostic agreement increased with p16 IHC (90.5% agreement, κ = 0.79 without p16; 92.0% agreement, κ = 0.84 with p16). For biopsy specimens taken from women positive for human papillomavirus (HPV) type 16, agreement was similar with or without adjunctive p16 (κ = 0.80 without p16; κ = 0.78-0.80 with p16). In contrast, p16 IHC substantially improved diagnostic agreement for cervical biopsy specimens taken from women positive for other high-risk HPV strains, producing improvements in κ from 0.03 to 0.24. Conclusions Adjunctive p16 immunostaining provides useful information in the evaluation of cervical biopsies for precancer. In our study, we have demonstrated that it is highly reproducible between 2 pathologists, although the decision of which biopsies warrant its use is less so. Furthermore, although p16 IHC showed a limited increase in diagnostic reproducibility for all biopsies included in our study, it did demonstrate a more sizable gain in biopsies negative for HPV 16 but positive for other high-risk genotypes. Further studies are needed to clarify the role of p16 IHC and how it can be optimized for the detection of cervical precancer, particularly in HPV-vaccinated populations where types other than HPV 16 are relatively more important. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma

Author

Tóth, Marcell, Wehling, Lilija, Thiess, Lena, Rose, Fabian, Schmitt, Jennifer, Weiler, Sofia M. E., Sticht, Carsten, De La Torre, Carolina, Rausch, Melina, Albrecht, Thomas, Grabe, Niels, Duwe, Lea, Andersen, Jesper B., Köhler, Bruno C., Springfeld, Christoph, Mehrabi, Arianeb, Kulu, Yakup, Schirmacher, Peter, Roessler, Stephanie, Goeppert, Benjamin, and Breuhahn, Kai

Published
2021
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3. Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients

Author

Xydia, Maria, Rahbari, Raheleh, Ruggiero, Eliana, Macaulay, Iain, Tarabichi, Maxime, Lohmayer, Robert, Wilkening, Stefan, Michels, Tillmann, Brown, Daniel, Vanuytven, Sebastiaan, Mastitskaya, Svetlana, Laidlaw, Sean, Grabe, Niels, Pritsch, Maria, Fronza, Raffaele, Hexel, Klaus, Schmitt, Steffen, Müller-Steinhardt, Michael, Halama, Niels, Domschke, Christoph, Schmidt, Manfred, von Kalle, Christof, Schütz, Florian, Voet, Thierry, and Beckhove, Philipp

Published
2021
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4. Identification and regulation of the long non-coding RNA Heat2 in heart failure

Author

Boeckel, Jes-Niels, Perret, Maya F., Glaser, Simone F., Seeger, Timon, Heumüller, Andreas W., Chen, Wei, John, David, Kokot, Karoline E., Katus, Hugo A., Haas, Jan, Lackner, Maximilian K., Kayvanpour, Elham, Grabe, Niels, Dieterich, Christoph, von Haehling, Stephan, Ebner, Nicole, Hünecke, Sabine, Leuschner, Florian, Fichtlscherer, Stephan, Meder, Benjamin, Zeiher, Andreas M., Dimmeler, Stefanie, and Keller, Till

Published
2019
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5. Revisiting the Training of Logic Models of Protein Signaling Networks with a Formal Approach based on Answer Set Programming

Author

Videla, Santiago, Guziolowski, Carito, Eduati, Federica, Thiele, Sven, Grabe, Niels, Saez-Rodriguez, Julio, and Siegel, Anne

Subjects
Quantitative Biology - Quantitative Methods, Computer Science - Artificial Intelligence, Computer Science - Computational Engineering, Finance, and Science, Computer Science - Learning
Abstract

A fundamental question in systems biology is the construction and training to data of mathematical models. Logic formalisms have become very popular to model signaling networks because their simplicity allows us to model large systems encompassing hundreds of proteins. An approach to train (Boolean) logic models to high-throughput phospho-proteomics data was recently introduced and solved using optimization heuristics based on stochastic methods. Here we demonstrate how this problem can be solved using Answer Set Programming (ASP), a declarative problem solving paradigm, in which a problem is encoded as a logical program such that its answer sets represent solutions to the problem. ASP has significant improvements over heuristic methods in terms of efficiency and scalability, it guarantees global optimality of solutions as well as provides a complete set of solutions. We illustrate the application of ASP with in silico cases based on realistic networks and data.

Published
2012
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6. HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice

Author

Hoefflin, Rouven, Harlander, Sabine, Schäfer, Silvia, Metzger, Patrick, Kuo, Fengshen, Schönenberger, Désirée, Adlesic, Mojca, Peighambari, Asin, Seidel, Philipp, Chen, Chia-yi, Consenza-Contreras, Miguel, Jud, Andreas, Lahrmann, Bernd, Grabe, Niels, Heide, Danijela, Uhl, Franziska M., Chan, Timothy A., Duyster, Justus, Zeiser, Robert, Schell, Christoph, Heikenwalder, Mathias, Schilling, Oliver, Hakimi, A. Ari, Boerries, Melanie, and Frew, Ian J.

Published
2020
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7. CNN stability training improves robustness to scanner and IHC-based image variability for epithelium segmentation in cervical histology

Author

Miranda Ruiz, Felipe, primary, Lahrmann, Bernd, additional, Bartels, Liam, additional, Krauthoff, Alexandra, additional, Keil, Andreas, additional, Härtel, Steffen, additional, Tao, Amy S., additional, Ströbel, Philipp, additional, Clarke, Megan A., additional, Wentzensen, Nicolas, additional, and Grabe, Niels, additional

Published
2023
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8. Suppl. Figure 8 from Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma

Author

Dettling, Steffen, primary, Stamova, Slava, primary, Warta, Rolf, primary, Schnölzer, Martina, primary, Rapp, Carmen, primary, Rathinasamy, Anchana, primary, Reuss, David, primary, Pocha, Kolja, primary, Roesch, Saskia, primary, Jungk, Christine, primary, Warnken, Uwe, primary, Eckstein, Volker, primary, Grabe, Niels, primary, Schramm, Christoph, primary, Weigand, Markus A., primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Beckhove, Philipp, primary, and Herold-Mende, Christel, primary

Published
2023
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9. Suppl. Figure 10 from Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma

Author

Dettling, Steffen, primary, Stamova, Slava, primary, Warta, Rolf, primary, Schnölzer, Martina, primary, Rapp, Carmen, primary, Rathinasamy, Anchana, primary, Reuss, David, primary, Pocha, Kolja, primary, Roesch, Saskia, primary, Jungk, Christine, primary, Warnken, Uwe, primary, Eckstein, Volker, primary, Grabe, Niels, primary, Schramm, Christoph, primary, Weigand, Markus A., primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Beckhove, Philipp, primary, and Herold-Mende, Christel, primary

Published
2023
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10. Suppl. Figure 9 from Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma

Author

Dettling, Steffen, primary, Stamova, Slava, primary, Warta, Rolf, primary, Schnölzer, Martina, primary, Rapp, Carmen, primary, Rathinasamy, Anchana, primary, Reuss, David, primary, Pocha, Kolja, primary, Roesch, Saskia, primary, Jungk, Christine, primary, Warnken, Uwe, primary, Eckstein, Volker, primary, Grabe, Niels, primary, Schramm, Christoph, primary, Weigand, Markus A., primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Beckhove, Philipp, primary, and Herold-Mende, Christel, primary

Published
2023
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11. Suppl. Table 2 from Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma

Author

Dettling, Steffen, primary, Stamova, Slava, primary, Warta, Rolf, primary, Schnölzer, Martina, primary, Rapp, Carmen, primary, Rathinasamy, Anchana, primary, Reuss, David, primary, Pocha, Kolja, primary, Roesch, Saskia, primary, Jungk, Christine, primary, Warnken, Uwe, primary, Eckstein, Volker, primary, Grabe, Niels, primary, Schramm, Christoph, primary, Weigand, Markus A., primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Beckhove, Philipp, primary, and Herold-Mende, Christel, primary

Published
2023
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12. Supplementary Figure Legends from Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma

Author

Dettling, Steffen, primary, Stamova, Slava, primary, Warta, Rolf, primary, Schnölzer, Martina, primary, Rapp, Carmen, primary, Rathinasamy, Anchana, primary, Reuss, David, primary, Pocha, Kolja, primary, Roesch, Saskia, primary, Jungk, Christine, primary, Warnken, Uwe, primary, Eckstein, Volker, primary, Grabe, Niels, primary, Schramm, Christoph, primary, Weigand, Markus A., primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Beckhove, Philipp, primary, and Herold-Mende, Christel, primary

Published
2023
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13. Supplementary Figure Legends from Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Author

Rapp, Carmen, primary, Dettling, Steffen, primary, Liu, Fang, primary, Ull, Anna Theresa, primary, Warta, Rolf, primary, Jungk, Christine, primary, Roesch, Saskia, primary, Mock, Andreas, primary, Sahm, Felix, primary, Schmidt, Melissa, primary, Jungwirth, Gerhard, primary, Zweckberger, Klaus, primary, Lamszus, Katrin, primary, Gousias, Konstaninos, primary, Kessler, Almuth F., primary, Grabe, Niels, primary, Loehr, Mario, primary, Ketter, Ralf, primary, Urbschat, Steffi, primary, Senft, Christian, primary, Westphal, Manfred, primary, Abdollahi, Amir, primary, Debus, Juergen, primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Simon, Matthias, primary, and Herold-Mende, Christel C., primary

Published
2023
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14. Supplementary Tables 1-2 from Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Author

Rapp, Carmen, primary, Dettling, Steffen, primary, Liu, Fang, primary, Ull, Anna Theresa, primary, Warta, Rolf, primary, Jungk, Christine, primary, Roesch, Saskia, primary, Mock, Andreas, primary, Sahm, Felix, primary, Schmidt, Melissa, primary, Jungwirth, Gerhard, primary, Zweckberger, Klaus, primary, Lamszus, Katrin, primary, Gousias, Konstaninos, primary, Kessler, Almuth F., primary, Grabe, Niels, primary, Loehr, Mario, primary, Ketter, Ralf, primary, Urbschat, Steffi, primary, Senft, Christian, primary, Westphal, Manfred, primary, Abdollahi, Amir, primary, Debus, Juergen, primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Simon, Matthias, primary, and Herold-Mende, Christel C., primary

Published
2023
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15. Suppl. Figure 2 from Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma

Author

Dettling, Steffen, primary, Stamova, Slava, primary, Warta, Rolf, primary, Schnölzer, Martina, primary, Rapp, Carmen, primary, Rathinasamy, Anchana, primary, Reuss, David, primary, Pocha, Kolja, primary, Roesch, Saskia, primary, Jungk, Christine, primary, Warnken, Uwe, primary, Eckstein, Volker, primary, Grabe, Niels, primary, Schramm, Christoph, primary, Weigand, Markus A., primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Beckhove, Philipp, primary, and Herold-Mende, Christel, primary

Published
2023
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16. Supplementary Figures 1-5 from Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Author

Rapp, Carmen, primary, Dettling, Steffen, primary, Liu, Fang, primary, Ull, Anna Theresa, primary, Warta, Rolf, primary, Jungk, Christine, primary, Roesch, Saskia, primary, Mock, Andreas, primary, Sahm, Felix, primary, Schmidt, Melissa, primary, Jungwirth, Gerhard, primary, Zweckberger, Klaus, primary, Lamszus, Katrin, primary, Gousias, Konstaninos, primary, Kessler, Almuth F., primary, Grabe, Niels, primary, Loehr, Mario, primary, Ketter, Ralf, primary, Urbschat, Steffi, primary, Senft, Christian, primary, Westphal, Manfred, primary, Abdollahi, Amir, primary, Debus, Juergen, primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Simon, Matthias, primary, and Herold-Mende, Christel C., primary

Published
2023
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17. Figure S7 from Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival

Author

Pocha, Kolja, primary, Mock, Andreas, primary, Rapp, Carmen, primary, Dettling, Steffen, primary, Warta, Rolf, primary, Geisenberger, Christoph, primary, Jungk, Christine, primary, Martins, Leila R., primary, Grabe, Niels, primary, Reuss, David, primary, Debus, Juergen, primary, von Deimling, Andreas, primary, Abdollahi, Amir, primary, Unterberg, Andreas, primary, and Herold-Mende, Christel C., primary

Published
2023
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18. Suppl. Figure 3 from Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma

Author

Dettling, Steffen, primary, Stamova, Slava, primary, Warta, Rolf, primary, Schnölzer, Martina, primary, Rapp, Carmen, primary, Rathinasamy, Anchana, primary, Reuss, David, primary, Pocha, Kolja, primary, Roesch, Saskia, primary, Jungk, Christine, primary, Warnken, Uwe, primary, Eckstein, Volker, primary, Grabe, Niels, primary, Schramm, Christoph, primary, Weigand, Markus A., primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Beckhove, Philipp, primary, and Herold-Mende, Christel, primary

Published
2023
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19. Suppl. Figure 6 from Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma

Author

Dettling, Steffen, primary, Stamova, Slava, primary, Warta, Rolf, primary, Schnölzer, Martina, primary, Rapp, Carmen, primary, Rathinasamy, Anchana, primary, Reuss, David, primary, Pocha, Kolja, primary, Roesch, Saskia, primary, Jungk, Christine, primary, Warnken, Uwe, primary, Eckstein, Volker, primary, Grabe, Niels, primary, Schramm, Christoph, primary, Weigand, Markus A., primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Beckhove, Philipp, primary, and Herold-Mende, Christel, primary

Published
2023
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20. Supplementary Data from Natural Killer Cells are Scarce in Colorectal Carcinoma Tissue Despite High Levels of Chemokines and Cytokines

Author

Halama, Niels, primary, Braun, Monika, primary, Kahlert, Christoph, primary, Spille, Anna, primary, Quack, Christian, primary, Rahbari, Nuh, primary, Koch, Moritz, primary, Weitz, Jürgen, primary, Kloor, Matthias, primary, Zoernig, Inka, primary, Schirmacher, Peter, primary, Brand, Karsten, primary, Grabe, Niels, primary, and Falk, Christine S., primary

Published
2023
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21. Supplementary Tables from Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival

Author

Pocha, Kolja, primary, Mock, Andreas, primary, Rapp, Carmen, primary, Dettling, Steffen, primary, Warta, Rolf, primary, Geisenberger, Christoph, primary, Jungk, Christine, primary, Martins, Leila R., primary, Grabe, Niels, primary, Reuss, David, primary, Debus, Juergen, primary, von Deimling, Andreas, primary, Abdollahi, Amir, primary, Unterberg, Andreas, primary, and Herold-Mende, Christel C., primary

Published
2023
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22. Suppl. Table 1, 3-8 from Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma

Author

Dettling, Steffen, primary, Stamova, Slava, primary, Warta, Rolf, primary, Schnölzer, Martina, primary, Rapp, Carmen, primary, Rathinasamy, Anchana, primary, Reuss, David, primary, Pocha, Kolja, primary, Roesch, Saskia, primary, Jungk, Christine, primary, Warnken, Uwe, primary, Eckstein, Volker, primary, Grabe, Niels, primary, Schramm, Christoph, primary, Weigand, Markus A., primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Beckhove, Philipp, primary, and Herold-Mende, Christel, primary

Published
2023
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23. Data from Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Author

Rapp, Carmen, primary, Dettling, Steffen, primary, Liu, Fang, primary, Ull, Anna Theresa, primary, Warta, Rolf, primary, Jungk, Christine, primary, Roesch, Saskia, primary, Mock, Andreas, primary, Sahm, Felix, primary, Schmidt, Melissa, primary, Jungwirth, Gerhard, primary, Zweckberger, Klaus, primary, Lamszus, Katrin, primary, Gousias, Konstaninos, primary, Kessler, Almuth F., primary, Grabe, Niels, primary, Loehr, Mario, primary, Ketter, Ralf, primary, Urbschat, Steffi, primary, Senft, Christian, primary, Westphal, Manfred, primary, Abdollahi, Amir, primary, Debus, Juergen, primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Simon, Matthias, primary, and Herold-Mende, Christel C., primary

Published
2023
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24. Data from Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy

Author

Halama, Niels, primary, Michel, Sara, primary, Kloor, Matthias, primary, Zoernig, Inka, primary, Benner, Axel, primary, Spille, Anna, primary, Pommerencke, Thora, primary, von Knebel, Doeberitz Magnus, primary, Folprecht, Gunnar, primary, Luber, Birgit, primary, Feyen, Nadine, primary, Martens, Uwe M., primary, Beckhove, Philipp, primary, Gnjatic, Sacha, primary, Schirmacher, Peter, primary, Herpel, Esther, primary, Weitz, Juergen, primary, Grabe, Niels, primary, and Jaeger, Dirk, primary

Published
2023
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25. Supplementary Figures 1-3, Table 1 from Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy

Author

Halama, Niels, primary, Michel, Sara, primary, Kloor, Matthias, primary, Zoernig, Inka, primary, Benner, Axel, primary, Spille, Anna, primary, Pommerencke, Thora, primary, von Knebel, Doeberitz Magnus, primary, Folprecht, Gunnar, primary, Luber, Birgit, primary, Feyen, Nadine, primary, Martens, Uwe M., primary, Beckhove, Philipp, primary, Gnjatic, Sacha, primary, Schirmacher, Peter, primary, Herpel, Esther, primary, Weitz, Juergen, primary, Grabe, Niels, primary, and Jaeger, Dirk, primary

Published
2023
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26. Segmentation of diagnostic tissue compartments on whole slide images with renal thrombotic microangiopathies (TMAs)

Author

Vo, Huy Q., Cicalese, Pietro A., Seshan, Surya, Rizvi, Syed A., Vathul, Aneesh, Bueno, Gloria, Dorado, Anibal Pedraza, Grabe, Niels, Stolle, Katharina, Pesce, Francesco, Roelofs, Joris J. T. H., Kers, Jesper, Bevilacqua, Vitoantonio, Altini, Nicola, Schröppel, Bernd, Roccatello, Dario, Barreca, Antonella, Sciascia, Savino, Mohan, Chandra, Nguyen, Hien V., Becker, Jan U., Vo, Huy Q., Cicalese, Pietro A., Seshan, Surya, Rizvi, Syed A., Vathul, Aneesh, Bueno, Gloria, Dorado, Anibal Pedraza, Grabe, Niels, Stolle, Katharina, Pesce, Francesco, Roelofs, Joris J. T. H., Kers, Jesper, Bevilacqua, Vitoantonio, Altini, Nicola, Schröppel, Bernd, Roccatello, Dario, Barreca, Antonella, Sciascia, Savino, Mohan, Chandra, Nguyen, Hien V., and Becker, Jan U.

Abstract

The thrombotic microangiopathies (TMAs) manifest in renal biopsy histology with a broad spectrum of acute and chronic findings. Precise diagnostic criteria for a renal biopsy diagnosis of TMA are missing. As a first step towards a machine learning- and computer vision-based analysis of wholes slide images from renal biopsies, we trained a segmentation model for the decisive diagnostic kidney tissue compartments artery, arteriole, glomerulus on a set of whole slide images from renal biopsies with TMAs and Mimickers (distinct diseases with a similar nephropathological appearance as TMA like severe benign nephrosclerosis, various vasculitides, Bevacizumab-plug glomerulopathy, arteriolar light chain deposition disease). Our segmentation model combines a U-Net-based tissue detection with a Shifted windows-transformer architecture to reach excellent segmentation results for even the most severely altered glomeruli, arterioles and arteries, even on unseen staining domains from a different nephropathology lab. With accurate automatic segmentation of the decisive renal biopsy compartments in human renal vasculopathies, we have laid the foundation for large-scale compartment-specific machine learning and computer vision analysis of renal biopsy repositories with TMAs., Comment: 12 pages, 3 figures

Published
2023

27. Spatio-temporal mathematical model describing the interplay between biomechanics and cell kinetics during fibrotic scar formation

Author

Zhao, Jieling, additional, Hammad, Seddik, additional, de Langlard, Mathieu, additional, Erdoesi, Pia, additional, Li, Yueni, additional, Van Liedekerke, Paul, additional, Buttenschoen, Andreas, additional, Grabe, Niels, additional, Hengstler, Jan, additional, Ebert, Matthias P., additional, Dooley, Steven, additional, and Drasdo, Dirk, additional

Published
2023
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28. Correlation between genomic index lesions and mpMRI and 68Ga-PSMA-PET/CT imaging features in primary prostate cancer

Author

Kesch, Claudia, Radtke, Jan-Philipp, Wintsche, Axel, Wiesenfarth, Manuel, Luttje, Mariska, Gasch, Claudia, Dieffenbacher, Svenja, Pecqueux, Carine, Teber, Dogu, Hatiboglu, Gencay, Nyarangi-Dix, Joanne, Simpfendörfer, Tobias, Schönberg, Gita, Dimitrakopoulou-Strauss, Antonia, Freitag, Martin, Duensing, Anette, Grüllich, Carsten, Jäger, Dirk, Götz, Michael, Grabe, Niels, Schweiger, Michal-Ruth, Pahernik, Sascha, Perner, Sven, Herpel, Esther, Roth, Wilfried, Wieczorek, Kathrin, Maier-Hein, Klaus, Debus, Jürgen, Haberkorn, Uwe, Giesel, Frederik, Galle, Jörg, Hadaschik, Boris, Schlemmer, Heinz-Peter, Hohenfellner, Markus, Bonekamp, David, Sültmann, Holger, and Duensing, Stefan

Published
2018
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30. Identification of T cell target antigens in glioblastoma stem-like cells using an integrated proteomics-based approach in patient specimens

Author

Rapp, Carmen, Warta, Rolf, Stamova, Slava, Nowrouzi, Ali, Geisenberger, Christoph, Gal, Zoltan, Roesch, Saskia, Dettling, Steffen, Juenger, Simone, Bucur, Mariana, Jungk, Christine, DaoTrong, Philip, Ahmadi, Rezvan, Sahm, Felix, Reuss, David, Fermi, Valentina, Herpel, Esther, Eckstein, Volker, Grabe, Niels, Schramm, Christoph, Weigand, Markus A., Debus, Juergen, von Deimling, Andreas, Unterberg, Andreas, Abdollahi, Amir, Beckhove, Philipp, and Herold-Mende, Christel

Published
2017
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35. Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain

Author

Geisenberger, Christoph, Mock, Andreas, Warta, Rolf, Rapp, Carmen, Schwager, Christian, Korshunov, Andrey, Nied, Ann-Katrin, Capper, David, Brors, Benedikt, Jungk, Christine, Jones, David, Collins, V. Peter, Ichimura, Koichi, Bäcklund, L. Magnus, Schnabel, Elena, Mittelbron, Michel, Lahrmann, Bernd, Zheng, Siyuan, Verhaak, Roel G. W., Grabe, Niels, Pfister, Stefan M., Hartmann, Christian, von Deimling, Andreas, Debus, Jürgen, Unterberg, Andreas, Abdollahi, Amir, and Herold-Mende, Christel

Published
2015
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36. Automated Evaluation of p16/Ki-67 Dual-Stain Cytology as a Biomarker for Detection of Anal Precancer in Men Who Have Sex With Men and Are Living With Human Immunodeficiency Virus

Author

Cohen, Camryn M, primary, Wentzensen, Nicolas, additional, Lahrmann, Bernd, additional, Tokugawa, Diane, additional, Poitras, Nancy, additional, Bartels, Liam, additional, Krauthoff, Alexandra, additional, Keil, Andreas, additional, Miranda, Felipe, additional, Castle, Philip E, additional, Lorey, Thomas, additional, Hare, Brad, additional, Darragh, Teresa M, additional, Grabe, Niels, additional, and Clarke, Megan A, additional

Published
2022
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38. LOC283731 promoter hypermethylation prognosticates survival after radiochemotherapy in IDH1 wild-type glioblastoma patients

Author

Mock, Andreas, Geisenberger, Christoph, Orlik, Christian, Warta, Rolf, Schwager, Christian, Jungk, Christine, Dutruel, Céline, Geiselhart, Lea, Weichenhan, Dieter, Zucknick, Manuela, Nied, Ann-Katrin, Friauf, Sara, Exner, Janina, Capper, David, Hartmann, Christian, Lahrmann, Bernd, Grabe, Niels, Debus, Jürgen, von Deimling, Andreas, Popanda, Odilia, Plass, Christoph, Unterberg, Andreas, Abdollahi, Amir, Schmezer, Peter, and Herold-Mende, Christel

Published
2016
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40. Therapeutic Effects of Inhibition of Sphingosine-1-Phosphate Signaling in HIF-2α Inhibitor-Resistant Clear Cell Renal Cell Carcinoma

Author

Hoefflin, Rouven, primary, Harlander, Sabine, additional, Abhari, Behnaz A., additional, Peighambari, Asin, additional, Adlesic, Mojca, additional, Seidel, Philipp, additional, Zodel, Kyra, additional, Haug, Stefan, additional, Göcmen, Burulca, additional, Li, Yong, additional, Lahrmann, Bernd, additional, Grabe, Niels, additional, Heide, Danijela, additional, Boerries, Melanie, additional, Köttgen, Anna, additional, Heikenwalder, Mathias, additional, and Frew, Ian J., additional

Published
2021
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45. HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas

Author

Kostareli, Efterpi, Holzinger, Dana, Bogatyrova, Olga, Hielscher, Thomas, Wichmann, Gunnar, Keck, Michaela, Lahrmann, Bernd, Grabe, Niels, Flechtenmacher, Christa, Schmidt, Christopher R., Seiwert, Tanguy, Dyckhoff, Gerhard, Dietz, Andreas, Hofler, Daniela, Pawlita, Michael, Benner, Axel, Bosch, Franz X., Plinkert, Peter, Plass, Christoph, Weichenhan, Dieter, and Hess, Jochen

Subjects
Methylation -- Analysis -- Physiological aspects -- Genetic aspects -- Research, Papillomavirus infections -- Development and progression -- Prognosis -- Patient outcomes -- Analysis -- Complications and side effects -- Genetic aspects -- Research, Squamous cell carcinoma -- Development and progression -- Prognosis -- Patient outcomes -- Analysis -- Causes of -- Genetic aspects -- Diagnosis -- Care and treatment -- Research, Health care industry
Abstract

High-risk types of human papilloma virus (HPV) are increasingly associated with oropharyngeal squamous cell carcinoma (OPSCC). Strikingly, patients with HPV-positive OPSCC are highly curable with ionizing radiation and have better [...]

Published
2013
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48. Expression Analysis of Aldehyde Dehydrogenase 1A1 (ALDH1A1) in Colon and Rectal Cancer in Association with Prognosis and Response to Chemotherapy

Author

Kahlert, Christoph, Gaitzsch, Eva, Steinert, Gunnar, Mogler, Carolin, Herpel, Esther, Hoffmeister, Michael, Jansen, Lina, Benner, Axel, Brenner, Hermann, Chang-Claude, Jenny, Rahbari, Nuh, Schmidt, Thomas, Klupp, Fee, Grabe, Niels, Lahrmann, Bernd, Koch, Moritz, Halama, Niels, Büchler, Markus, and Weitz, Juergen

Published
2012
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49. Additional file 2 of Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma

Author

Tóth, Marcell, Wehling, Lilija, Thiess, Lena, Rose, Fabian, Schmitt, Jennifer, Weiler, Sofia M. E., Sticht, Carsten, De La Torre, Carolina, Rausch, Melina, Albrecht, Thomas, Grabe, Niels, Duwe, Lea, Andersen, Jesper B., Köhler, Bruno C., Springfeld, Christoph, Mehrabi, Arianeb, Kulu, Yakup, Schirmacher, Peter, Roessler, Stephanie, Goeppert, Benjamin, and Breuhahn, Kai

Abstract

Additional file 2: Figure S2. Function of YAP/TAZ expression in HuH-28 and G415 cells

Published
2021
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50. Additional file 3 of Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma

Author

Tóth, Marcell, Wehling, Lilija, Thiess, Lena, Rose, Fabian, Schmitt, Jennifer, Weiler, Sofia M. E., Sticht, Carsten, De La Torre, Carolina, Rausch, Melina, Albrecht, Thomas, Grabe, Niels, Duwe, Lea, Andersen, Jesper B., Köhler, Bruno C., Springfeld, Christoph, Mehrabi, Arianeb, Kulu, Yakup, Schirmacher, Peter, Roessler, Stephanie, Goeppert, Benjamin, and Breuhahn, Kai

Subjects
fungi, parasitic diseases, information science, cardiovascular system, cardiovascular diseases
Abstract

Additional file 3: Figure S3. Expression analysis of CCA cell lines after YAP/TAZ inhibition

Published
2021
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