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Your search keyword '"Graña-Miraglia, Lucía"' showing total 19 results
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19 results on '"Graña-Miraglia, Lucía"'

1. Development and Validation of an Integrative Risk Score for Future Risk of Crohn’s Disease in Healthy First-Degree Relatives: A Multicenter Prospective Cohort Study

Author

Lee, Sun-Ho, Turpin, Williams, Espin-Garcia, Osvaldo, Xu, Wei, Leibovitzh, Haim, Xue, Mingyue, Raygoza Garay, Juan Antonio, Graña-Miraglia, Lucía, Smith, Michelle I., Goethel, Ashleigh, Madsen, Karen L., Avni-Biron, Irit, Dotan, Iris, Weiss, Batia, Panaccione, Remo, Huynh, Hien, Jacobson, Kevan, Aumais, Guy, Mack, David, Griffiths, Anne M., Steinhart, A. Hillary, Silverberg, Mark S., Turner, Dan, Bernstein, Charles N., Feagan, Brian G., Moayyedi, Paul, Paterson, Andrew, Guttman, David S., Abreu, Maria, Beck, Paul, Dieleman, Leo, Kaplan, Gilaad, Krause, Denis O., Marshall, John, Ropeleski, Mark, Seidman, Ernest, Snapper, Scott, Stadnyk, Andy, Surette, Michael, Walters, Thomas, Vallance, Bruce, Bitton, Alain, Cino, Maria, Critch, Jeff, Denson, Lee, Deslandres, Colette, El-Matary, Wael, Herfarth, Hans, Higgins, Peter, Hyams, Jeff, McGrath, Jerry, Otley, Anthony, and Croitoru, Kenneth

Published
2025
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2. Total substitution and partial modification of the set of non-ribosomal peptide synthetases clusters lead to pyoverdine diversity in the Pseudomonas fluorescens complex.

Author

Graña-Miraglia, Lucía, Geney Higuita, Jorge Luis, Salazar, Juan Carlos, Guaya Iñiguez, Diana, Alcolado León, Carlos, and García-Angulo, Víctor A.

Subjects
NONRIBOSOMAL peptide synthetases, PSEUDOMONAS fluorescens, PEPTIDES, DOMAIN specificity, HORIZONTAL gene transfer
Abstract

Pyoverdines are high affinity siderophores produced by most Pseudomonas with a wide role in microbial interspecies interactions. They are primarily composed of a conserved chromophore moiety, an acyl side chain and a peptide backbone which may be highly variable among strains. Upon ferric iron sequestration, pyoverdines are internalized through specialized receptors. The peptide precursor of pyoverdine, termed ferribactin, is synthesized by a set of non-ribosomal peptide synthetase (NRPS) enzymes and further modified by tailoring enzymes. While PvdL, the NRPS responsible for the synthesis of the peptide moiety that derives into the chromophore is conserved, the NRPSs for the peptide backbone are different across fluorescent Pseudomonas. Although the variation of pyoverdine is a widely recognized characteristic within the genus, the evolutionary events associated with the diversity and distribution of this trait remain mostly unknown. This study analyzed the NRPSs clusters for the biosynthesis of the peptide backbone of ferribactin in the genomes of a representative subset of strains of the Pseudomonas fluorescens complex. Bioinformatic analysis of the specificity of adenylation domains of the NRPSs allowed the prediction of 30 different pyoverdine variants. Phylogenetic reconstruction and mapping of the NRPS clusters pinpointed two different general levels of modifications. In the first level, a complete replacement of the set of NRPRs by horizontal transfer occurs. In the second level, the original set of NRPSs is modified through different mechanisms, including partial substitution of the NRPS genes by horizontal transfer, adenylation domain specificity change or NRPS accessory domain gain/loss. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Epidemiology of healthcare-associated Pseudomonas aeruginosa in intensive care units: Are sink drains to blame?

Author

Volling, Cheryl, primary, Mataseje, Laura, additional, Graña-Miraglia, Lucía, additional, Hu, Xiaoyi, additional, Anceva-Sami, Sofia, additional, Coleman, Brenda L., additional, Downing, Mark, additional, Hota, Susy, additional, Jamal, Alainna J., additional, Johnstone, Jennie, additional, Katz, Kevin, additional, Leis, Jerome A., additional, Li, Angel, additional, Mahesh, Vinaya, additional, Melano, Roberto, additional, Muller, Matthew, additional, Nayani, Sarah, additional, Patel, Samir, additional, Paterson, Aimee, additional, Pejkovska, Mare, additional, Ricciuto, Daniel, additional, Sultana, Asfia, additional, Vikulova, Tamara, additional, Zhong, Zoe, additional, McGeer, Allison, additional, Guttman, David S., additional, and Mulvey, Michael R., additional

Published
2024
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9. 27 DEVELOPMENT AND VALIDATION OF AN INTEGRATED RISK SCORE FOR PREDICTING FUTURE RISK OF CROHN'S DISEASE UP TO 7 YEARS BEFORE DIAGNOSIS IN HEALTHY FIRST-DEGREE RELATIVES: THE CCCGEM PROJECT, A MULTICENTRE PROSPECTIVE COHORT STUDY

Author

Lee, Sun-Ho, Turpin, Williams, Espin-Garcia, Osvaldo, Leibovitzh, Haim, Xue, Mingyue, Grana-Miraglia, Lucia, Smith, Michelle I., Goethel, Ashleigh, Madsen, Karen, Avni-Biron, Irit, Dotan, Iris, Vais, Batia, Panaccione, Remo, Huynh, Hien Q., Jacobson, Kevan, Aumais, Guy L., Mack, David R., Griffiths, Anne M., Steinhart, A. Hillary, Silverberg, Mark S., Turner, Dan, Bernstein, Charles N., Feagan, Brian G., Moayyedi, Paul, Paterson, Andrew D., Guttman, David S., Xu, Wei, and Croitoru, Kenneth

Published
2024
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10. Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide

Author

Isabel, Sandra, primary, Graña-Miraglia, Lucía, additional, Gutierrez, Jahir M., additional, Bundalovic-Torma, Cedoljub, additional, Groves, Helen E., additional, Isabel, Marc R., additional, Eshaghi, AliReza, additional, Patel, Samir N., additional, Gubbay, Jonathan B., additional, Poutanen, Tomi, additional, Guttman, David S., additional, and Poutanen, Susan M., additional

Published
2020
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11. Rejection of the name Borreliella and all proposed species comb. nov. placed therein

Author

Margos, Gabriele, primary, Castillo-Ramirez, Santiago, additional, Cutler, Sally, additional, Dessau, Ram B., additional, Eikeland, Randi, additional, Estrada-Peña, Agustin, additional, Gofton, Alexander, additional, Graña-Miraglia, Lucía, additional, Hunfeld, Klaus-Peter, additional, Krause, Andreas, additional, Lienhard, Reto, additional, Lindgren, Per-Eric, additional, Oskam, Charlotte, additional, Rudolf, Ivo, additional, Schwartz, Ira, additional, Sing, Andreas, additional, Stevenson, Brian, additional, Wormser, Gary P., additional, and Fingerle, Volker, additional

Published
2020
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14. Unexplored Genetic Diversity of Multidrug- and Extremely Drug-Resistant Acinetobacter baumannii Isolates from Tertiary Hospitals in Honduras

Author

López-Leal, Gamaliel, primary, Zuniga-Moya, Julio César, additional, Castro-Jaimes, Semiramis, additional, Graña-Miraglia, Lucía, additional, Pérez-Oseguera, Ángeles, additional, Reyes-García, Hilda Sarahi, additional, Gough-Coto, Simmons David, additional, Pavón-Madrid, René, additional, Bejarano, Suyapa Aurora, additional, Ferrera, Annabelle, additional, Castillo-Ramírez, Santiago, additional, and Cevallos, Miguel A., additional

Published
2019
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17. Complete Genome Sequence of a Multidrug-Resistant Acinetobacter baumannii Isolate Obtained from a Mexican Hospital (Sequence Type 422)

Author

Castro-Jaimes, Semiramis, primary, Salgado-Camargo, Abraham David, additional, Graña-Miraglia, Lucía, additional, Lozano, Luis, additional, Bocanegra-Ibarias, Paola, additional, Volkow-Fernández, Patricia, additional, Silva-Sanchez, Jesus, additional, Castillo-Ramírez, Santiago, additional, and Cevallos, Miguel A., additional

Published
2016
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19. Description of genome sequences of arthropod-associated spirochetes of the genus Entomospira .

Author

Sikutova S, Graña-Miraglia L, Vancová M, Bílý T, Sing A, Castillo-Ramirez S, Rudolf I, Margos G, and Fingerle V

Abstract

Spirochetal bacteria isolated from arthropods of the genera Culex and Aedes are termed BR149, BR151 ( Entomospira culicis ), BR193 ( Entomospira entomophila ), and BR208 ( Entomospira nematocerorum ). Genome sizes assembled from Illumina MiSeq and Oxford Nanopore reads varied between 1.67 and 1.78 Mb containing three to six plasmids. GC content ranged from 38.5% to 45.76%., Competing Interests: The authors declare no conflict of interest.

Published
2024
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