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1,068 results on '"Grünig, Ekkehard"'

5. Oral Treprostinil is Associated with Improved Survival in FREEDOM-EV and its Open-Label Extension

Author

Grünig, Ekkehard, Rahaghi, Franck, Elwing, Jean, Vizza, Carmine Dario, Pepke-Zaba, Joanna, Shen, Jieyan, Yao, Hua, Hage, Antoine, Rosenkranz, Stephan, Vonk, Madelon, Balasubramanian, Vijay, Yuanhua, Yang, Yu, Zaixin, Lordan, James, Cadaret, Linda, Grover, Rob, Ousmanou, Aliou, Seaman, Scott, Deng, Chunqin, Broderick, Meredith, and White, R. James

Published
2024
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7. Comparison of Contemporary Risk Scores in All Groups of Pulmonary Hypertension: A Pulmonary Vascular Research Institute GoDeep Meta-Registry Analysis

Author

Antoine, Tobiah, Backofen, Achim, Cannon, John, Damonte, Victoria, Echazarreta, Diego, Eichstaedt, Christina, Elwing, Jean, Förster, Kai, Gruenig, Ekkehard, Hilgendorff, Anne, Jose, Arun, Junaeda, Ernesto, Krieb, Philipp, Marquardt, Kurt, Osborn, Karen, Pepke-Zaba, Johanna, Tilea, Ioan, Varga, Andreea, Yogeswaran, Athiththan, Gall, Henning, Fünderich, Meike, Wilkins, Martin R., Howard, Luke, Kiely, David G., Lawrie, Allan, Hassoun, Paul M., Sirenklo, Yuriy, Torbas, Olena, Sweatt, Andrew J., Zamanian, Roham T., Williams, Paul G., Frauendorf, Marlize, Arvanitaki, Alexandra, Giannakoulas, George, Saleh, Khaled, Sabbour, Hani, Cajigas, Hector R., Frantz, Robert, Al Ghouleh, Imad, Chan, Stephen Y., Brittain, Evan, Annis, Jeffrey S., Pepe, Antonella, Ghio, Stefano, Orfanos, Stylianos, Anthi, Anastasia, Majeed, Raphael W., Wilhelm, Jochen, Ghofrani, Hossein Ardeschir, Richter, Manuel J., Grimminger, Friedrich, Sahay, Sandeep, Tello, Khodr, and Seeger, Werner

Published
2024
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8. Positive Vasoreactivity Testing in Pulmonary Arterial Hypertension: Therapeutic Consequences, Treatment Patterns, and Outcomes in the Modern Management Era

Author

Gerhardt, Felix, Fiessler, Eva, Olsson, Karen M., Kayser, Moritz Z., Kovacs, Gabor, Gall, Henning, Ghofrani, H. Ardeschir, Badr Eslam, Roza, Lang, Irene M., Benjamin, Nicola, Grünig, Ekkehard, Halank, Michael, Lange, Tobias J., Ulrich, Silvia, Leuchte, Hanno, Held, Matthias, Klose, Hans, Ewert, Ralf, Wilkens, Heinrike, Pizarro, Carmen, Skowasch, Dirk, Wissmüller, Max, Hellmich, Martin, Olschewski, Horst, Hoeper, Marius M., and Rosenkranz, Stephan

Published
2024
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9. Seralutinib in adults with pulmonary arterial hypertension (TORREY): a randomised, double-blind, placebo-controlled phase 2 trial

Author

Adir, Yochai, Baillie, Timothy, Baratz, David, Burger, Charles, Chakinala, Murali M., Cifrián Martínez, Jose Manual, Delcroix, Marion, Dwyer, Nathan, Elwing, Jean M., Fisher, Micah, Franco, Veronica, Grünig, Ekkehard, Highland, Kristin, Hill, Nicholas, Hirani, Naushad, Hoeper, Marius, Jansa, Pavel, Keogh, Anne, Kingrey, John, Lopez-Meseguer, Manuel, McConnell, John W., Mehta, Sanjay, Melendres-Groves, Lana, Opitz, Christian, Pepke-Zaba, Joanna, Pillutla, Priya, Rahaghi, Franck, Raina, Amresh, Raviv, Yael, Robinson, Jeffrey, Ryan, John, Sager, Jeffrey, Shapiro, Shelley, Simon, Marc, Smith, Kerri, Sobol, Irina R., Sood, Namita, Spikes, Leslie A., Stadler, Stefan, Stevens, Wendy, Sulica, Roxana, White, R. James, Frantz, Robert P, McLaughlin, Vallerie V, Sahay, Sandeep, Escribano Subías, Pilar, Zolty, Ronald L, Benza, Raymond L, Channick, Richard N, Chin, Kelly M, Hemnes, Anna R, Howard, Luke S, Sitbon, Olivier, Vachiéry, Jean-Luc, Zamanian, Roham T, Cravets, Matt, Roscigno, Robert F, Mottola, David, Osterhout, Robin, Bruey, Jean-Marie, Elman, Erin, Tompkins, Cindy-ann, Parsley, Ed, Aranda, Richard, Zisman, Lawrence S, and Ghofrani, Hossein-Ardeschir

Published
2024
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15. Safety and effectiveness of standardized exercise training in patients with pulmonary hypertension associated with heart failure with preserved ejection fraction (TRAIN-HFpEF-PH): study protocol for a randomized controlled multicenter trial

Author

Palevičiūtė, Eglė, Čelutkienė, Jelena, Šimbelytė, Toma, Gumbienė, Lina, Jurevičienė, Elena, Zakarkaitė, Diana, Čėsna, Sigitas, Eichstaedt, Christina A., Benjamin, Nicola, and Grünig, Ekkehard

Published
2023
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16. An open‐label, dose‐escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of GSK2586881 in participants with pulmonary arterial hypertension

Author

Simon, Marc A, Hanrott, Kate, Budd, David C, Torres, Fernando, Grünig, Ekkehard, Escribano‐Subias, Pilar, Meseguer, Manuel L, Halank, Michael, Opitz, Christian, Hall, David A, Hewens, Deborah, Powley, William M, Siederer, Sarah, Bayliffe, Andrew, Lazaar, Aili L, Cahn, Anthony, and Rosenkranz, Stephan

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Lung, Cardiovascular, Clinical Research, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, 6.2 Cellular and gene therapies, arterial hypertension, hemodynamics, recombinant human angiotensin-converting enzyme 2, renin-angiotensin system, rhACE2, recombinant human angiotensin‐converting enzyme 2, renin‐angiotensin system, Cardiorespiratory Medicine and Haematology, Cardiovascular medicine and haematology
Abstract

Preclinical and early clinical studies suggest that angiotensin-converting enzyme type 2 activity may be impaired in patients with pulmonary arterial hypertension (PAH); therefore, administration of exogenous angiotensin-converting enzyme type 2 (ACE2) may be beneficial. This Phase IIa, multi-center, open-label, exploratory, single-dose, dose-escalation study (NCT03177603) assessed the potential vasodilatory effects of single doses of GSK2586881 (a recombinant human ACE2) on acute cardiopulmonary hemodynamics in hemodynamically stable adults with documented PAH who were receiving background PAH therapy. Successive cohorts of participants were administered a single intravenous dose of GSK2586881 of 0.1, 0.2, 0.4, or 0.8 mg/kg. Dose escalation occurred after four or more participants per cohort were dosed and a review of safety, tolerability, pharmacokinetics, and hemodynamic data up to 24 h postdose was undertaken. The primary endpoint was a change in cardiopulmonary hemodynamics (pulmonary vascular resistance, cardiac index, and mean pulmonary artery pressure) from baseline. Secondary/exploratory objectives included safety and tolerability, effect on renin-angiotensin system peptides, and pharmacokinetics. GSK2586881 demonstrated no consistent or sustained effect on acute cardiopulmonary hemodynamics in participants with PAH receiving background PAH therapy (N = 23). All doses of GSK2586881 were well tolerated. GSK2586881 was quantifiable in plasma for up to 4 h poststart of infusion in all participants and caused a consistent and sustained reduction in angiotensin II and a corresponding increase in angiotensin (1-7) and angiotensin (1-5). While there does not appear to be a consistent acute vasodilatory response to single doses of GSK2586881 in participants with PAH, the potential benefits in terms of chronic vascular remodeling remain to be determined.

Published
2022

18. Defining the clinical validity of genes reported to cause pulmonary arterial hypertension

Author

Callejo, Emily P., Day, Kristina M., Macaya, Daniela, Maldonado-Velez, Gabriel, Archer, Stephen L., Auckland, Kathryn, Austin, Eric D., Badagliacca, Roberto, Barberà, Joan-Albert, Belge, Catharina, Bogaard, Harm Jan, Bonnet, Sébastien, Boomars, Karin A., Boucherat, Olivier, Chakinala, Murali M., Condliffe, Robin, Damico, Rachel Lynn, Delcroix, Marion, Desai, Ankit A., Doboszynska, Anna, Elliott, C. Greg, Eyries, Melanie, Escribano Subías, Maria Pilar, Gall, Henning, Ghio, Stefano, Ghofrani, Ardeschir-Hossein, Grünig, Ekkehard, Hamid, Rizwan, Harbaum, Lars, Hassoun, Paul M., Hemnes, Anna R., Hinderhofer, Katrin, Howard, Luke S., Humbert, Marc, Kiely, David G., Langleben, David, Lawrie, Allan, Loyd, Jim E., Moledina, Shahin, Montani, David, Morrell, Nichols W., Nichols, William C., Olschewski, Andrea, Olschewski, Horst, Papa, Silvia, Pauciulo, Mike W., Provencher, Steve, Quarck, Rozenn, Rhodes, Christopher J., Scelsi, Laura, Seeger, Werner, Stewart, Duncan J., Sweatt, Andrew, Swietlik, Emilia M., Treacy, Carmen, Trembath, Richard C., Tura-Ceide, Olga, Vizza, Carmine Dario, Vonk Noordegraaf, Anton, Wilkins, Martin R., Zamanian, Roham T., Zateyshchikov, Dmitry, Welch, Carrie L., Aldred, Micheala A., Balachandar, Srimmitha, Dooijes, Dennis, Eichstaedt, Christina A., Gräf, Stefan, Houweling, Arjan C., Machado, Rajiv D., Pandya, Divya, Prapa, Matina, Shaukat, Memoona, Southgate, Laura, Tenorio-Castano, Jair, and Chung, Wendy K.

Published
2023
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20. Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension. A Double-Blind Placebo-controlled Clinical Trial.

Author

White, R, Jerjes-Sanchez, Carlos, Bohns Meyer, Gisela, Pulido, Tomas, Sepulveda, Pablo, Wang, Kuo, Grünig, Ekkehard, Hiremath, Shirish, Yu, Zaixin, Gangcheng, Zhang, Yip, Wei, Zhang, Shuyang, Khan, Akram, Deng, C, Grover, Rob, and Tapson, Victor

Subjects
clinical study, combination therapy, oral treprostinil, pulmonary arterial hypertension, sequential therapy, Administration, Oral, Adolescent, Adult, Aged, Antihypertensive Agents, Double-Blind Method, Epoprostenol, Female, Humans, Male, Middle Aged, Placebos, Pulmonary Arterial Hypertension, Young Adult
Abstract

Rationale: Oral treprostinil improves exercise capacity in patients with pulmonary arterial hypertension (PAH), but the effect on clinical outcomes was unknown.Objectives: To evaluate the effect of oral treprostinil compared with placebo on time to first adjudicated clinical worsening event in participants with PAH who recently began approved oral monotherapy.Methods: In this event-driven, double-blind study, we randomly allocated 690 participants (1:1 ratio) with PAH to receive placebo or oral treprostinil extended-release tablets three times daily. Eligible participants were using approved oral monotherapy for over 30 days before randomization and had a 6-minute-walk distance 150 m or greater. The primary endpoint was the time to first adjudicated clinical worsening event: death; hospitalization due to worsening PAH; initiation of inhaled or parenteral prostacyclin therapy; disease progression; or unsatisfactory long-term clinical response.Measurements and Main Results: Clinical worsening occurred in 26% of the oral treprostinil group compared with 36% of placebo participants (hazard ratio, 0.74; 95% confidence interval, 0.56-0.97; P = 0.028). Key measures of disease status, including functional class, Borg dyspnea score, and N-terminal pro-brain natriuretic peptide, all favored oral treprostinil treatment at Week 24 and beyond. A noninvasive risk stratification analysis demonstrated that oral treprostinil-assigned participants had a substantially higher mortality risk at baseline but achieved a lower risk profile from Study Weeks 12-60. The most common adverse events in the oral treprostinil group were headache, diarrhea, flushing, nausea, and vomiting.Conclusions: In participants with PAH, addition of oral treprostinil to approved oral monotherapy reduced the risk of clinical worsening.Clinical trial registered with www.clinicaltrials.gov (NCT01560624).

Published
2020

21. Efficacy and safety of riociguat in combination therapy for patients with pulmonary arterial hypertension (PATENT studies).

Author

Ghofrani, Hossein-Ardeschir, Grünig, Ekkehard, Jansa, Pavel, Langleben, David, Rosenkranz, Stephan, Preston, Ioana, Rahaghi, Franck, Sood, Namita, Busse, Dennis, Meier, Christian, and Humbert, Marc

Subjects
endothelin receptor antagonists, hemodynamics, hypertension, prostaglandins, pulmonary, soluble guanylyl cyclase
Abstract

Many patients with pulmonary arterial hypertension do not achieve treatment goals with monotherapy, and therefore combination therapy is becoming the standard of care. The soluble guanylate cyclase stimulator riociguat is licensed for the treatment of pulmonary arterial hypertension; here we present findings from patients who were receiving combined riociguat plus endothelin receptor antagonists or non-intravenous prostanoids in the randomized, placebo-controlled PATENT-1 study and its open-label extension (PATENT-2). Moreover, we include new data from patients receiving early sequential combination therapy (three to six months of endothelin receptor antagonist treatment) or long-term background endothelin receptor antagonist therapy (>6 months). Patients were randomized to riociguat 2.5 mg-maximum (N = 131 pretreated patients) and placebo (N = 60 pretreated patients). Riociguat improved 6-min walking distance (PATENT-1 primary endpoint), functional capacity, and hemodynamics after 12 weeks in pretreated patients. The placebo-corrected changes in 6-min walking distance were +24 m in endothelin receptor antagonist-pretreated patients and +106 m in the small group of prostanoid-pretreated patients. In the early sequential combination and long-term background endothelin receptor antagonist groups, the placebo-corrected changes in 6-min walking distance were +65 m (95% CI: 17 to 113 m) and +13 m (95% CI: -8 to 33 m), respectively. In conclusion, these data suggest that early sequential combination of an endothelin receptor antagonist plus riociguat is a feasible treatment option. Both early sequential therapy and long-term background endothelin receptor antagonist plus riociguat were well tolerated in the PATENT studies.

Published
2020

23. Risk stratification and response to therapy in patients with pulmonary arterial hypertension and comorbidities: A COMPERA analysis

Author

Rosenkranz, Stephan, Pausch, Christine, Coghlan, John G., Huscher, Doerte, Pittrow, David, Grünig, Ekkehard, Staehler, Gerd, Vizza, Carmine Dario, Gall, Henning, Distler, Oliver, Delcroix, Marion, Ghofrani, Hossain A., Ewert, Ralf, Kabitz, Hans-Joachim, Skowasch, Dirk, Behr, Juergen, Milger, Katrin, Halank, Michael, Wilkens, Heinrike, Seyfarth, Hans-Jürgen, Held, Matthias, Scelsi, Laura, Neurohr, Claus, Vonk-Noordegraaf, Anton, Ulrich, Silvia, Klose, Hans, Claussen, Martin, Eisenmann, Stephan, Schmidt, Kai-Helge, Remppis, Bjoern Andrew, Skride, Andris, Jureviciene, Elena, Gumbiene, Lina, Miliauskas, Skaidrius, Löffler-Ragg, Judith, Lange, Tobias J., Olsson, Karen M., Hoeper, Marius M., and Opitz, Christian

Published
2023
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25. Pulmonale Hypertonie bei Erwachsenen mit angeborenen Herzfehlern im Lichte der 2022-ESC-PAH-Leitlinien

Author

Kaemmerer, Harald, additional, Diller, Gerhard Paul, additional, Achenbach, Stephan, additional, Dähnert, Ingo, additional, Eichstaedt, Christina A., additional, Eicken, Andreas, additional, Freiberger, Annika, additional, Freilinger, Sebastian, additional, Geiger, Ralf, additional, Gorenflo, Matthias, additional, Grünig, Ekkehard, additional, Hager, Alfred, additional, Huntgeburth, Michael, additional, Kaemmerer-Suleiman, Ann-Sophie, additional, Kozlik-Feldmann, Rainer, additional, Lammers, Astrid E., additional, Nagdyman, Nicole, additional, Michel, Sebastian, additional, Schmidt, Kai Helge, additional, Uebing, Anselm, additional, von Scheidt, Fabian, additional, and Apitz, Christian, additional

Published
2024
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26. Phenotyping of idiopathic pulmonary arterial hypertension: a registry analysis

Author

Hoeper, Marius M, Dwivedi, Krit, Pausch, Christine, Lewis, Robert A, Olsson, Karen M, Huscher, Doerte, Pittrow, David, Grünig, Ekkehard, Staehler, Gerd, Vizza, Carmine Dario, Gall, Henning, Distler, Oliver, Opitz, Christian, Gibbs, John Simon R, Delcroix, Marion, Park, Da-Hee, Ghofrani, Hossein Ardeschir, Ewert, Ralf, Kaemmerer, Harald, Kabitz, Hans-Joachim, Skowasch, Dirk, Behr, Juergen, Milger, Katrin, Lange, Tobias J, Wilkens, Heinrike, Seyfarth, Hans-Jürgen, Held, Matthias, Dumitrescu, Daniel, Tsangaris, Iraklis, Vonk-Noordegraaf, Anton, Ulrich, Silvia, Klose, Hans, Claussen, Martin, Eisenmann, Stephan, Schmidt, Kai-Helge, Swift, Andrew J, Thompson, Alfred A Roger, Elliot, Charlie A, Rosenkranz, Stephan, Condliffe, Robin, Kiely, David G, and Halank, Michael

Published
2022
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29. Gene panel diagnostics reveals new pathogenic variants in pulmonary arterial hypertension

Author

Eichstaedt, Christina A., Saßmannshausen, Zoe, Shaukat, Memoona, Cao, Ding, Xanthouli, Panagiota, Gall, Henning, Sommer, Natascha, Ghofrani, Hossein-Ardeschir, Seyfarth, Hans-Jürgen, Lerche, Marianne, Halank, Michael, Kleymann, Janina, Benjamin, Nicola, Harutyunova, Satenik, Egenlauf, Benjamin, Milger, Katrin, Rosenkranz, Stephan, Ewert, Ralf, Klose, Hans, Hoeper, Marius M., Olsson, Karen M., Lankeit, Mareike, Lange, Tobias J., Hinderhofer, Katrin, and Grünig, Ekkehard

Published
2022
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30. Age-changes in right ventricular function–pulmonary circulation coupling: from pediatric to adult stage in 1899 healthy subjects. The RIGHT Heart International NETwork (RIGHT-NET)

Author

Vriz, Olga, Veldman, Gruschen, Gargani, Luna, Ferrara, Francesco, Frumento, Paolo, D’Alto, Michele, D’Andrea, Antonello, Radaan, Sarah Aldosari, Cocchia, Rosangela, Marra, Alberto Maria, Ranieri, Brigida, Salzano, Andrea, Stanziola, Anna Agnese, Voilliot, Damien, Agoston, Gergely, Cademartiri, Filippo, Cittadini, Antonio, Kasprzak, Jaroslaw D., Grünig, Ekkehard, Bandera, Francesco, Guazzi, Marco, Rudski, Lawrence, and Bossone, Eduardo

Published
2021
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32. Switching to riociguat versus maintenance therapy with phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension (REPLACE): a multicentre, open-label, randomised controlled trial

Author

Olschewski, H, Delcroix, M, Andrade-Lima, M, de Amorim Corrêac, R, Figueiredo Campos, F, Ota Arakaki, J, Meyer, G, De Souza, R, Langleben, D, Al-Hiti, H, Jansa, P, Mellemkjær, S, Bauer, F, Montani, D, Simonneau, G, Drömann, D, Ghofrani, H-A, Grünig, E, Halank, M, Held, M, Hoeper, MM, Klose, H, Kneidinger, N, Leuchte, H, Opitz, C, Rosenkranz, S, Wilkens, H, Wirtz, H, Karvounis, H, Pitsiou, G, Orfanos, S, D'Alto, M, Ghio, S, Vizza, CD, Vitulo, P, Nakayama, T, Maki, H, Tatebe, S, de los Rios Ibarra, M, Pulido, T, Van Dijk, A, Vonk-Noordegraaf, A, Roleder, T, Castro, G, Loureiro, MJ, Robalo-Martins, S, Barberá, JA, Lázaro, M, Perez-Penate, GM, Román, A, Cheng, C-C, Hsu, C-H, Hsu, H-H, Atahan, E, Mogulkoc Bishop, N, Okumus, NG, Onen, Z, Chang, H-J, Chang, S-A, Lee, J-S, Kim, H-K, Coghlan, JG, Corris, PA, Church, AC, Condliffe, R, Gibbs, JSR, Peacock, AJ, Wort, S, Allen, R, Allen, S, Awdish, R, Benza, RL, DeSouza, S, Feldman, J, Johri, S, Klinger, JR, Layish, D, McConnell, J, McLaughlin, VV, Migliore, C, Rahaghi, F, Rischard, F, Robbins, I, Satterwhite, L, Shah, T, Sulica, R, White, RJ, Hoeper, Marius M, Al-Hiti, Hikmet, Benza, Raymond L, Chang, Sung-A, Corris, Paul A, Gibbs, J Simon R, Grünig, Ekkehard, Jansa, Pavel, Klinger, James R, Langleben, David, McLaughlin, Vallerie V, Meyer, Gisela M B, Ota-Arakaki, Jaquelina, Peacock, Andrew J, Pulido, Tomás, Rosenkranz, Stephan, Vizza, Carmine Dario, Vonk-Noordegraaf, Anton, White, R James, Chang, Mikyung, Kleinjung, Frank, Meier, Christian, Paraschin, Karen, Ghofrani, Hossein Ardeschir, and Simonneau, Gérald

Published
2021
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33. Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Author

Caneva, Jorge, Tuhay, Graciela, Diez, Mirta, Talavera, Maria Lujan, Acosta, Adriana, Vulcano, Norberto, Bosio, Martin, Maldonado, Lorena, Deleo, Sabino, Melatini, Luciano, Keogh, Anne, Kotlyar, Eugene, Feenstra, John, Dwyer, Nathan, Adams, Heath, Stevens, Wendy, Steele, Peter, Proudman, Susanna, Minson, Robert, Reeves, Glenn, Lavender, Melanie, Ng, Benjamin, Mackenzie, Michele, Barry, Lisa, Gruenberger, Margarethe, Huber, Charlotte, Lang, Irene, Tilea, Ioana, Sadushi-Kolici, Roela, Löffler-Ragg, Judith, Feistmantl, Lisa-Theresa, Evrard, Patrick, Louis, Renaud, Guiot, Julien, Naldi, Marco, De Pauw, Michel, Mehta, Sanjay, Camacho, Rafael Conde, Tovar, Patricia Parada, Londoño, Alejandro, Campo, Felipe, Garcia, Paula, Lema, Camila, Orozco-Levi, Mauricio, Martinez, William, Gomez, Juan Esteban, Nielsen-Kudsk, Jens Erik, Mellemkjaer, Soren, Anton, Ly, Altraja, Alan, Vihinen, Tapani, Vasankari, Tuija, Sitbon, Olivier, Cottin, Vincent, Têtu, Laurent, Noël-Savina, Elise, Shearman, Nicole, Tayler, Susanne, Olzik, Ilona, Kulka, Christine, Grimminger, Jan, Simon, Marcel, Nolde, Anna, Oqueka, Tim, Harbaum, Lars, Egenlauf, Benjamin, Ewert, Ralf, Schulz, Christian, Regotta, Sabine, Kramer, Tilmann, Knoop-Busch, Susanne, Gerhardt, Felix, Konstantinides, Stavros, Pitsiou, Georgia, Stanopoulos, Ioannis, Sourla, Evdokia, Mouratoglou, Sofia, Karvounis, Haralambos, Pappas, Athanasios, Georgopoulos, Dimitrios, Fanaridis, Michail, Mitrouska, Ioanna, Michalis, Lampros, Pappas, Konstantinos, Kotsia, Anna, Gaine, Sean, Vizza, Carmine Dario, Manzi, Giovanna, Poscia, Roberto, Badagliacca, Roberto, Agostoni, Piergiuseppe, Bruno, Noemi, Farina, Stefania, D'Alto, Michele, Argiento, Paola, Correra, Anna, Di Marco, Giovanni Maria, Cresci, Chiara, Vannucchi, Vieri, Torricelli, Elena, Garcea, Alessio, Pesci, Alberto, Sardella, Luca, Paciocco, Giuseppe, Pane, Federico, D'Armini, Andrea Maria, Pin, Maurizio, Grazioli, Valentina, Massola, Giulia, Sciortino, Antonio, Prediletto, Renato, Bauleo, Carolina, Airò, Edoardo, Ndreu, Rudina, Pavlickova, Ivana, Lunardi, Claudio, Mulè, Massimiliano, Farruggio, Silvia, Costa, Serena, Galgano, Giuseppe, Petruzzi, Mario, De Luca, Anna, Lombardi, Francesco, Roncon, Loris, Conte, Luca, Picariello, Claudio, Wirtz, Gil, Alexandre, Myriam, Vonk-Noordegraaf, A., Boogaard, H., Mager, J., Reesink, H., van den Toorn, Leon M., Boomars, Karin, Andreassen, Arne K., Castro, Graça, Tania, Gonçalves, Baptista, Rui, Marinho, António, Shiang, Teresa, Oliveira, Ana, Coutinho, Daniel, Sousa, Joana, Loureiro, Maria José, Repolho, Débora, Martins Jesus, Susana Maria, Capinha, Marta, Agostinho, João, Cardoso, Tania, Rocha, Andreia, Espinha, Mafalda, Ivanov, Kyundyul Ivanovich, Alexeeva, Dalyana Eduardovna, Batalina, Marina Vadimovna, Hegya, Daria Viktorovna, Zvereva, Tatyana Nikolaevna, Avdeev, Sergey Nikolaevich, Tsareva, Natalia Anatolievna, Galyavich, Albert Sarvatovich, Nikolaevich, Bykov Aleksander, Filippov, Evgeny Vladimirovich, Yakovleva, Olga Eduardovna, Pavlova, Olga Borisovna, Skripkina, Elena Sergeevna, Martynyuk, Tamila Vitalievna, Bukatova, Irina Fedorovna, Tregubova, Anna Viktorovna, Platonov, Dmitry Yurievich, Kolomeytseva, Tatyana Mikhaylovna, Al Dalaan, Abdullah, Abdelsayed, Abeer Abeer, Weheba, Ihab, Saleemi, Sarferaz, Sakkijha, Hussam, Bohacekova, Marcela, Valkovicova, Tatiana, Farkasova, Iveta, Quezada, Carlos Andres, Piccari, Lucilla, Blanco, Isabel, Sebastian, Laura, Roman, Antonio, Lopez, Manuel, Otero, Remedios, Elias, Teresa, Jara, Luis, Asencio, Isabel, Arjona, Josefa Jiménez, Almagro, Raúl Menor, Cárdenas, Salvador López, García, Salvador Alcaraz, Rodríguez, Patricia Villanueva, Lopez, Raquel, Garcia, Alberto, Avilés, Francisco Fernandez, De La Pava, Sebastian, Yotti, Raquel, Peñate, Gregorio Pérez, Marrero, Fernando León, Cifrián Martínez, José Manuel, Martinez-Meñaca, Amaya, Alonso, Lecue Pilar, Rozas, Sonia Fernandez, Fernandez, David Iturbe, Cuesta, Victor Mora, Söderberg, Stefan, Bartfay, Sven-Erik, Rundqvist, Bengt, Alfetlawi, Monthir, Wodlin, Peter, Schwarz, Esther Irene, Speich, Rudolf, Lador, Frédéric, Rochat, Thierry, Gasche-Soccal, Paola, Hsu, Chih-Hsin, Lin, Tsung-Hsien, Su, Ho-Ming, Lai, Wen-Ter, Chu, Chun Yuan, Hsu, Po-Chao, Voon, Wen-Chol, Yen, Hsueh-Wei, Yih-Jer Wu, Jacob, Wu, Shu-Hao, Huang, Wen-Pin, Fong, Man-Cai, Huang, Chien-Lung, Kuo, Ping-Hung, Lin, Yen-Hung, Lin, Jiunn-Lee, Hung, Chi-Sheng, Wu, Cho-Kai, Sung, Shih-Hsien, Huang, Wei-Chun, Cheng, Chin-Chang, Kuo, Shu-Hung, Wang, Wen-Hwa, Ho, Wan-Jing, Hsu, Tsu-Shiu, Mutlu, Bülent, Atas, Halil, Ongen, Gul, Un, Zeynep, Okumus, Gulfer, Hanta, Ismail, Corris, Paul, Peacock, Andrew, Church, Colin, Toshner, Mark, Newnham, Michael, Ghofrani, Hossein-Ardeschir, Gomez Sanchez, Miguel-Angel, Humbert, Marc, Pittrow, David, Simonneau, Gérald, Gall, Henning, Grünig, Ekkehard, Klose, Hans, Halank, Michael, Langleben, David, Snijder, Repke J., Escribano Subias, Pilar, Mielniczuk, Lisa M., Lange, Tobias J., Vachiéry, Jean-Luc, Wirtz, Hubert, Helmersen, Douglas S., Tsangaris, Iraklis, Barberá, Joan A., Pepke-Zaba, Joanna, Boonstra, Anco, Rosenkranz, Stephan, Ulrich, Silvia, Steringer-Mascherbauer, Regina, Delcroix, Marion, Jansa, Pavel, Šimková, Iveta, Giannakoulas, George, Klotsche, Jens, Williams, Evgenia, Meier, Christian, and Hoeper, Marius M.

Published
2021
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34. Riociguat treatment in patients with pulmonary arterial hypertension: Final safety data from the EXPERT registry

Author

Caneva, Jorge, Tuhay, Graciela, Diez, Mirta, Talavera, Maria Lujan, Acosta, Adriana, Vulcano, Norberto, Bosio, Martin, Maldonado, Lorena, Deleo, Sabino, Melatini, Luciano, Keogh, Anne, Kotlyar, Eugene, Feenstra, John, Dwyer, Nathan, Adams, Heath, Stevens, Wendy, Steele, Peter, Proudman, Susanna, Minson, Robert, Reeves, Glenn, Lavender, Melanie, Ng, Benjamin, Mackenzie, Michele, Barry, Lisa, Gruenberger, Margarethe, Huber, Charlotte, Lang, Irene, Tilea, Ioana, Sadushi-Kolici, Roela, Löffler-Ragg, Judith, Feistmantl, Lisa-Theresa, Evrard, Patrick, Guiot, Julien, Naldi, Marco, De Pauw, Michel, Louis, Renaud, Mehta, Sanjay, Camacho, Rafael Conde, Tovar, Patricia Parada, Londoño, Alejandro, Campo, Felipe, Garcia, Paula, Lema, Camila, Orozco-Levi, Mauricio, Martinez, William, Gomez, Juan Esteban, Nielsen-Kudsk, Jens Erik, Mellemkjaer, Soren, Anton, Ly, Altraja, Alan, Vihinen, Tapani, Vasankari, Tuija, Sitbon, Olivier, Cottin, Vincent, Têtu, Laurent, Noël-Savina, Elise, Shearman, Nicole, Tayler, Susanne, Olzik, Ilona, Kulka, Christine, Grimminger, Jan, Simon, Marcel, Nolde, Anna, Oqueka, Tim, Harbaum, Lars, Egenlauf, Benjamin, Ewert, Ralf, Schulz, Christian, Regotta, Sabine, Kramer, Tilmann, Knoop-Busch, Susanne, Gerhardt, Felix, Konstantinides, Stavros, Pitsiou, Georgia, Stanopoulos, Ioannis, Sourla, Evdokia, Mouratoglou, Sofia, Karvounis, Haralambos, Pappas, Athanasios, Mitrouska, Ioanna, Georgopoulos, Dimitrios, Fanaridis, Michail, Michalis, Lampros, Pappas, Konstantinos, Kotsia, Anna, Gaine, Sean, Vizza, Carmine Dario, Manzi, Giovanna, Poscia, Roberto, Badagliacca, Roberto, Agostoni, Piergiuseppe, Bruno, Noemi, Farina, Stefania, D'Alto, Michele, Argiento, Paola, Correra, Anna, Di Marco, Giovanni Maria, Cresci, Chiara, Vannucchi, Vieri, Torricelli, Elena, Garcea, Alessio, Pesci, Alberto, Sardella, Luca, Paciocco, Giuseppe, Pane, Federico, D'Armini, Andrea Maria, Pin, Maurizio, Grazioli, Valentina, Massola, Giulia, Sciortino, Antonio, Prediletto, Renato, Bauleo, Carolina, Airò, Edoardo, Ndreu, Rudina, Pavlickova, Ivana, Lunardi, Claudio, Farruggio, Silvia, Costa, Serena, Mulè, Massimiliano, Galgano, Giuseppe, Petruzzi, Mario, De Luca, Anna, Lombardi, Francesco, Roncon, Loris, Conte, Luca, Picariello, Claudio, Wirtz, Gil, Alexandre, Myriam, Vonk-Noordegraaf, A., Boogaard, H., Mager, J., Reesink, H., van den Toorn, Leon M., Boomars, Karin, Andreassen, Arne K., Castro, Graça, Tania, Gonçalves, Baptista, Rui, Marinho, António, Shiang, Teresa, Oliveira, Ana, Coutinho, Daniel, Sousa, Joana, Loureiro, Maria José, Repolho, Débora, Martins Jesus, Susana Maria, Capinha, Marta, Agostinho, João, Cardoso, Tania, Rocha, Andreia, Espinha, Mafalda, Ivanov, Kyundyul Ivanovich, Alexeeva, Dalyana Eduardovna, Batalina, Marina Vadimovna, Hegya, Daria Viktorovna, Zvereva, Tatyana Nikolaevna, Avdeev, Sergey Nikolaevich, Tsareva, Natalia Anatolievna, Galyavich, Albert Sarvatovich, Nikolaevich, Bykov Aleksander, Filippov, Evgeny Vladimirovich, Yakovleva, Olga Eduardovna, Pavlova, Olga Borisovna, Skripkina, Elena Sergeevna, Martynyuk, Tamila Vitalievna, Bukatova, Irina Fedorovna, Tregubova, Anna Viktorovna, Platonov, Dmitry Yurievich, Kolomeytseva, Tatyana Mikhaylovna, Al Dalaan, Abdullah, Abdelsayed, Abeer Abeer, Weheba, Ihab, Saleemi, Sarferaz, Sakkijha, Hussam, Bohacekova, Marcela, Valkovicova, Tatiana, Farkasova, Iveta, Quezada, Carlos Andres, Piccari, Lucilla, Blanco, Isabel, Sebastian, Laura, Roman, Antonio, Lopez, Manuel, Otero, Remedios, Elias, Teresa, Jara, Luis, Asencio, Isabel, Arjona, Josefa Jiménez, Almagro, Raúl Menor, Cárdenas, Salvador López, García, Salvador Alcaraz, Rodríguez, Patricia Villanueva, Lopez, Raquel, Garcia, Alberto, Avilés, Francisco Fernandez, De La Pava, Sebastian, Yotti, Raquel, Peñate, Gregorio Pérez, Marrero, Fernando León, Cifrián Martínez, José Manuel, Martinez-Meñaca, Amaya, Alonso, Lecue Pilar, Rozas, Sonia Fernandez, Fernandez, David Iturbe, Cuesta, Victor Mora, Söderberg, Stefan, Bartfay, Sven-Erik, Rundqvist, Bengt, Alfetlawi, Monthir, Wodlin, Peter, Schwarz, Esther Irene, Speich, Rudolf, Lador, Frédéric, Rochat, Thierry, Gasche-Soccal, Paola, Hsu, Chih-Hsin, Lin, Tsung-Hsien, Su, Ho-Ming, Lai, Wen-Ter, Chu, Chun Yuan, Hsu, Po-Chao, Voon, Wen-Chol, Yen, Hsueh-Wei, Yih-Jer Wu, Jacob, Wu, Shu-Hao, Huang, Wen-Pin, Fong, Man-Cai, Huang, Chien-Lung, Kuo, Ping-Hung, Lin, Yen-Hung, Lin, Jiunn-Lee, Hung, Chi-Sheng, Wu, Cho-Kai, Sung, Shih-Hsien, Huang, Wei-Chun, Cheng, Chin-Chang, Kuo, Shu-Hung, Wang, Wen-Hwa, Ho, Wan-Jing, Hsu, Tsu-Shiu, Mutlu, Bülent, Atas, Halil, Ongen, Gul, Un, Zeynep, Okumus, Gulfer, Hanta, Ismail, Corris, Paul, Peacock, Andrew, Church, Colin, Toshner, Mark, Newnham, Michael, Hoeper, Marius M., Gomez Sanchez, Miguel-Angel, Humbert, Marc, Pittrow, David, Simonneau, Gérald, Gall, Henning, Grünig, Ekkehard, Klose, Hans, Halank, Michael, Langleben, David, Snijder, Repke J., Escribano Subias, Pilar, Mielniczuk, Lisa M., Lange, Tobias J., Vachiéry, Jean-Luc, Wirtz, Hubert, Helmersen, Douglas S., Tsangaris, Iraklis, Barberà, Joan A., Pepke-Zaba, Joanna, Boonstra, Anco, Rosenkranz, Stephan, Ulrich, Silvia, Steringer-Mascherbauer, Regina, Delcroix, Marion, Jansa, Pavel, Šimková, Iveta, Giannakoulas, George, Klotsche, Jens, Williams, Evgenia, Meier, Christian, and Ghofrani, Hossein-Ardeschir

Published
2021
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35. Performance of DETECT PAH algorithm according to the hemodynamic definition of pulmonary arterial hypertension (PAH) in the 2022 ESC/ERS guidelines: Early detection of pulmonary arterial hypertension in systemic sclerosis patients

Author

Distler, Oliver; https://orcid.org/0000-0002-2413-1959, Bonderman, Diana, Coghlan, J Gerry, Denton, Christopher P; https://orcid.org/0000-0003-3975-8938, Grünig, Ekkehard, Khanna, Dinesh; https://orcid.org/0000-0003-1412-4453, McLaughlin, Vallerie V, Müller-Ladner, Ulf, Pope, Janet E; https://orcid.org/0000-0003-1479-5302, Vonk, Madelon C; https://orcid.org/0000-0002-2266-9907, Di Scala, Lilla, Lemarie, Jean-Christophe, Perchenet, Loïc, Hachulla, Éric, Distler, Oliver; https://orcid.org/0000-0002-2413-1959, Bonderman, Diana, Coghlan, J Gerry, Denton, Christopher P; https://orcid.org/0000-0003-3975-8938, Grünig, Ekkehard, Khanna, Dinesh; https://orcid.org/0000-0003-1412-4453, McLaughlin, Vallerie V, Müller-Ladner, Ulf, Pope, Janet E; https://orcid.org/0000-0003-1479-5302, Vonk, Madelon C; https://orcid.org/0000-0002-2266-9907, Di Scala, Lilla, Lemarie, Jean-Christophe, Perchenet, Loïc, and Hachulla, Éric

Abstract

OBJECTIVE: The evidence-based DETECT pulmonary arterial hypertension (PAH) algorithm is frequently used in systemic sclerosis (SSc) patients to help clinicians screen for PAH by using non-invasive data to recommend patient referral to echocardiography, and if applicable, for a diagnostic right heart catheterization (RHC). However, the hemodynamic definition of PAH was recently updated in the 2022 ESC/ERS guidelines. The performance of DETECT PAH in identifying patients with a high risk of PAH according to this new definition was assessed. METHODS: In this post-hoc analysis of DETECT, which comprised 466 SSc patients the performance of the DETECT PAH algorithm in identifying patients with a high risk of PAH as defined in the 2022 ESC/ERS guidelines (mean pulmonary arterial pressure [mPAP] >20 mmHg, pulmonary capillary wedge pressure [PCWP] ≤15 mmHg, pulmonary vascular resistance [PVR] >2 Wood Units was assessed using summary statistics and was descriptively compared to the known performance of DETECT PAH as defined in 2014 when it was developed (mPAP ≥25 mmHg and PCWP ≤15 mmHg). RESULTS: The sensitivity of DETECT PAH in identifying patients with a high risk of PAH according to the 2022 ESC/ERS definition was lower (88.2%) compared to the 2014 definition (95.8%). Specificity improved from 47.8% to 50.8%. CONCLUSION: The performance of the DETECT algorithm to screen for PAH in SSc patients is maintained when PAH is defined according to the 2022 ESC/ERS hemodynamic definition, indicating that DETECT remains applicable to screen for PAH in SSc patients.

Published
2024

36. Idiopathic pulmonary arterial hypertension phenotypes determined by cluster analysis from the COMPERA registry

Author

Hoeper, Marius M., Pausch, Christine, Grünig, Ekkehard, Klose, Hans, Staehler, Gerd, Huscher, Doerte, Pittrow, David, Olsson, Karen M., Vizza, Carmine Dario, Gall, Henning, Benjamin, Nicola, Distler, Oliver, Opitz, Christian, Gibbs, J. Simon R., Delcroix, Marion, Ghofrani, H. Ardeschir, Rosenkranz, Stephan, Ewert, Ralf, Kaemmerer, Harald, Lange, Tobias J., Kabitz, Hans-Joachim, Skowasch, Dirk, Skride, Andris, Jureviciene, Elena, Paleviciute, Egle, Miliauskas, Skaidrius, Claussen, Martin, Behr, Juergen, Milger, Katrin, Halank, Michael, Wilkens, Heinrike, Wirtz, Hubert, Pfeuffer-Jovic, Elena, Harbaum, Lars, Scholtz, Werner, Dumitrescu, Daniel, Bruch, Leonhard, Coghlan, Gerry, Neurohr, Claus, Tsangaris, Iraklis, Gorenflo, Matthias, Scelsi, Laura, Vonk-Noordegraaf, Anton, Ulrich, Silvia, and Held, Matthias

Published
2020
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38. Air travel in patients suffering from pulmonary hypertension—A prospective, multicentre study.

Author

Yogeswaran, Athiththan, Grimminger, Jan, Tello, Khodr, Becker, Lukas, Seeger, Werner, Grimminger, Friedrich, Sommer, Natascha, Ghofrani, Hossein A., Lange, Tobias J., Stadler, Stefan, Olsson, Karen, Kamp, Jan C., Rosenkranz, Stephan, Gerhardt, Felix, Milger, Katrin, Barnikel, Michaela, Ulrich, Silvia, Saxer, Stéphanie, Grünig, Ekkehard, and Harutynova, Satenik

Subjects
PULMONARY arterial hypertension, AIR travel safety, ADVERSE health care events, PULMONARY hypertension, MEDICAL consultation
Abstract

The PEGASUS study is the first multicentric and prospective assessment of the safety of air travel flying in pulmonary hypertension (PH) (NCT03051763). Data of air travel from 60 patients with PH was available. No severe adverse events occurred. Nine patients self‐reported mild adverse events during flight (13%), while after landing, 12 patients reported events (20%). Solely one patient (2%) had an adverse event leading to medical consultation. In patients with PH and World Health Organization functional classes II and III, air travel was safe. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Performance of DETECT Pulmonary Arterial Hypertension Algorithm According to the Hemodynamic Definition of Pulmonary Arterial Hypertension in the 2022 European Society of Cardiology and the European Respiratory Society Guidelines.

Author

Distler, Oliver, Bonderman, Diana, Coghlan, J. Gerry, Denton, Christopher P., Grünig, Ekkehard, Khanna, Dinesh, McLaughlin, Vallerie V., Müller‐Ladner, Ulf, Pope, Janet E., Vonk, Madelon C., Di Scala, Lilla, Lemarie, Jean‐Christophe, Perchenet, Loïc, and Hachulla, Éric

Subjects
PULMONARY artery physiology, CROSS-sectional method, DATA analysis, RESEARCH funding, CLINICAL trials, PULMONARY artery, HEMODYNAMICS, DESCRIPTIVE statistics, ARTERIAL pressure, VASCULAR resistance, SYSTEMIC scleroderma, STATISTICS, RESEARCH, PULMONARY arterial hypertension, MEDICAL screening, BLOOD pressure, COMPARATIVE studies, ALGORITHMS, ECHOCARDIOGRAPHY, CARDIAC catheterization, SENSITIVITY & specificity (Statistics), DISEASE complications
Abstract

Objective: The evidence‐based DETECT pulmonary arterial hypertension (PAH) algorithm is frequently used in patients with systemic sclerosis (SSc) to help clinicians screen for PAH by using noninvasive data to recommend patient referral to echocardiography and, if applicable, for a diagnostic right‐sided heart catheterization. However, the hemodynamic definition of PAH was recently updated in the 2022 European Society of Cardiology (ESC)/European Respiratory Society (ERS) guidelines. The performance of DETECT PAH in identifying patients with a high risk of PAH according to this new definition was assessed. Methods: In this post hoc analysis of DETECT, which comprised 466 patients with SSc, the performance of the DETECT PAH algorithm in identifying patients with a high risk of PAH as defined in the 2022 ESC/ERS guidelines (mean pulmonary arterial pressure [mPAP] >20 mm Hg, pulmonary capillary wedge pressure [PCWP] ≤15 mm Hg, and pulmonary vascular resistance >2 Wood units) was assessed using summary statistics and was descriptively compared to the known performance of DETECT PAH as defined in 2014, when it was developed (mPAP ≥25 mm Hg and PCWP ≤15 mm Hg). Results: The sensitivity of DETECT PAH in identifying patients with a high risk of PAH according to the 2022 ESC/ERS definition was lower (88.2%) compared to the 2014 definition (95.8%). Specificity improved from 47.8% to 50.8%. Conclusion: The performance of the DETECT algorithm to screen for PAH in patients with SSc is maintained when PAH is defined according to the 2022 ESC/ERS hemodynamic definition, indicating that DETECT remains applicable to screen for PAH in patients with SSc. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Performance of DETECT PAH algorithm according to the hemodynamic definition of pulmonary arterial hypertension (PAH) in the 2022 ESC/ERS guidelines

Author

Distler, Oliver, primary, Bonderman, Diana, additional, Coghlan, J Gerry, additional, Denton, Christopher P, additional, Grünig, Ekkehard, additional, Khanna, Dinesh, additional, McLaughlin, Vallerie V, additional, Müller‐Ladner, Ulf, additional, Pope, Janet E, additional, Vonk, Madelon C, additional, Di Scala, Lilla, additional, Lemarie, Jean‐Christophe, additional, Perchenet, Loïc, additional, and Hachulla, Éric, additional

Published
2023
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43. Pulmonale arterielle Hypertonie bei Erwachsenen mit angeborenen Herzfehlern – Teil I

Author

Kaemmerer, Harald, additional, Diller, Gerhard Paul, additional, Dähnert, Ingo, additional, Eichstaedt, Christina A., additional, Eicken, Andreas, additional, Freiberger, Annika, additional, Freilinger, Sebastian, additional, Geiger, Ralf, additional, Gorenflo, Matthias, additional, Grünig, Ekkehard, additional, Hager, Alfred, additional, Herberg, Ulrike, additional, Huntgeburth, Michael, additional, Kaemmerer, Ann-Sophie, additional, Kozlik-Feldmann, Rainer, additional, Lammers, Astrid, additional, Nagdyman, Nicole, additional, Michel, Sebastian, additional, Schmidt, Kai Helge, additional, Uebing, Anselm, additional, von Scheidt, Fabian, additional, and Apitz, Christian, additional

Published
2023
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44. Medikamentöse Therapie der pulmonalarteriellen Hypertonie mit Komorbiditäten – Welche Phänotypen gibt es, was gibt es zu beachten?

Author

Grünig, Ekkehard, additional, Halank, Michael, additional, Neurohr, Claus, additional, Behr, Jürgen, additional, Milger-Kneidinger, Katrin, additional, Ronczka, Julia, additional, Lichtblau, Mona, additional, Benjamin, Nicola, additional, Lange, Tobias J., additional, Ulrich, Silvia, additional, Wilkens, Heinrike, additional, Grohé, Christian, additional, and Skowasch, Dirk, additional

Published
2023
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45. Exercise Stress Echocardiography of the Right Ventricle and Pulmonary Circulation

Author

Gargani, Luna, primary, Pugliese, Nicola Riccardo, additional, De Biase, Nicolò, additional, Mazzola, Matteo, additional, Agoston, Gergely, additional, Arcopinto, Michele, additional, Argiento, Paola, additional, Armstrong, William F., additional, Bandera, Francesco, additional, Cademartiri, Filippo, additional, Carbone, Andreina, additional, Castaldo, Rossana, additional, Citro, Rodolfo, additional, Cocchia, Rosangela, additional, Codullo, Veronica, additional, D’Alto, Michele, additional, D'Andrea, Antonello, additional, Douschan, Philipp, additional, Fabiani, Iacopo, additional, Ferrara, Francesco, additional, Franzese, Monica, additional, Frumento, Paolo, additional, Ghio, Stefano, additional, Grünig, Ekkehard, additional, Guazzi, Marco, additional, Kasprzak, Jaroslaw D., additional, Kolias, Theodore, additional, Kovacs, Gabor, additional, La Gerche, André, additional, Limogelli, Giuseppe, additional, Marra, Alberto Maria, additional, Matucci-Cerinic, Marco, additional, Mauro, Ciro, additional, Moreo, Antonella, additional, Pratali, Lorenza, additional, Ranieri, Brigida, additional, Rega, Salvatore, additional, Rudski, Lawrence, additional, Saggar, Rajan, additional, Salzano, Andrea, additional, Serra, Walter, additional, Stanziola, Anna A., additional, Vannan, Mani A., additional, Voilliot, Damien, additional, Vriz, Olga, additional, Wierzbowska-Drabik, Karina, additional, Cittadini, Antonio, additional, Naeije, Robert, additional, Bossone, Eduardo, additional, Gargani, Luna, additional, Kolias, Theodore John, additional, Capone, Valentina, additional, Sepe, Chiara, additional, Capuano, Francesco, additional, Benvenga, Rossella, additional, Bellino, Michele, additional, Iuliano, Giuseppe, additional, Migliarino, Serena, additional, Radano, Ilaria, additional, Marra, Alberto, additional, Crisci, Giulia, additional, D’Assante, Roberta, additional, De Luca, Mariarosaria, additional, Giardino, Federica, additional, Rainone, Carmen, additional, Valente, Valeria, additional, D’Andrea, Antonello, additional, Russo, Valentina, additional, Dellegrottaglie, Santo, additional, Di Salvo, Giovanni, additional, Guida, Stefania, additional, Grunig, Ekkerard, additional, Eichstaedt, Christina A., additional, Labate, Valentina, additional, La Gerch, André, additional, Limongelli, Giuseppe, additional, Pacileo, Giuseppe, additional, Verrengia, Marina, additional, Casadei, Francesca, additional, De Chiara, Benedetta, additional, Ostenfeld, Ellen, additional, Pedrizzetti, Gianni, additional, Pieri, Francesco, additional, Mori, Fabio, additional, Moggi-Pignone, Alberto, additional, Raciti, Mauro, additional, Pugliese, Nicola, additional, D’Angelo, Gennaro, additional, Stanziola, Anna Agnese, additional, Rossella, D’Angelo, additional, Gallotta, Lorena, additional, Szabó, István, additional, Varga, Albert, additional, Galzerano, Domenico, additional, Vannan, Mani, additional, Mobasseri, Sara, additional, Flueckiger, Peter, additional, and Liu, Shizhen, additional

Published
2023
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46. Die neue Definition und Klassifikation der pulmonalen Hypertonie

Author

Douschan, Philipp, primary, Egenlauf, Benjamin, primary, Ulrich, Silvia, primary, Kovacs, Gabor, primary, Gall, Henning, additional, Grünig, Ekkehard, additional, Hager, Alfred, additional, Heberling, Melanie, additional, Koehler, Thomas, additional, Olschewski, Horst, additional, Seyfarth, Hans-Jürgen, additional, and Yogeswaran, Athiththan, additional

Published
2023
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47. Allgemeine Maßnahmen und Management der pulmonalarteriellen Hypertonie

Author

Lichtblau, Mona, additional, Harutyunova, Satenik, additional, Nechwatal, Robert, additional, Mayer, Laura, additional, Kabitz, Hans-Joachim, additional, Wilkens, Finn Moritz, additional, Uiker, Sören, additional, Grünig, Ekkehard, additional, Ritter, Daniel, additional, Florea, Andreea, additional, and Benjamin, Nicola, additional

Published
2023
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49. NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD

Author

Seimetz, Michael, Sommer, Natascha, Bednorz, Mariola, Pak, Oleg, Veith, Christine, Hadzic, Stefan, Gredic, Marija, Parajuli, Nirmal, Kojonazarov, Baktybek, Kraut, Simone, Wilhelm, Jochen, Knoepp, Fenja, Henneke, Ingrid, Pichl, Alexandra, Kanbagli, Zeki I., Scheibe, Susan, Fysikopoulos, Athanasios, Wu, Cheng-Yu, Klepetko, Walter, Jaksch, Peter, Eichstaedt, Christina, Grünig, Ekkehard, Hinderhofer, Katrin, Geiszt, Miklós, Müller, Niklas, Rezende, Flavia, Buchmann, Giulia, Wittig, Ilka, Hecker, Matthias, Hecker, Andreas, Padberg, Winfried, Dorfmüller, Peter, Gattenlöhner, Stefan, Vogelmeier, Claus F., Günther, Andreas, Karnati, Srikanth, Baumgart-Vogt, Eveline, Schermuly, Ralph T., Ghofrani, Hossein A., Seeger, Werner, Schröder, Katrin, Grimminger, Friedrich, Brandes, Ralf P., and Weissmann, Norbert

Published
2020
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